Detailed information for compound 312478

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 607.712 | Formula: C26H29O5Re
  • H donors: 2 H acceptors: 5 LogP: 6.05 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@H]([C@H](c1ccc(cc1)O)CCC1C=CC=C1)c1ccc(cc1)O.O=C[Re](C=O)C=O
  • InChi: 1S/C23H26O2.3CHO.Re/c1-2-22(18-8-12-20(24)13-9-18)23(16-7-17-5-3-4-6-17)19-10-14-21(25)15-11-19;3*1-2;/h3-6,8-15,17,22-25H,2,7,16H2,1H3;3*1H;/t22-,23+;;;;/m1..../s1
  • InChiKey: KPSDXNWYGFHXSQ-GSELRKFWSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Calpain-like protein 1.2 0.0385 0.0682 0.1917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Onchocerca volvulus Cathepsin L homolog 0.0294 0.0446 0.0776
Brugia malayi programmed cell death protein 6 0.0225 0.0266 0.0229
Giardia lamblia Encystation-specific protease 0.0294 0.0446 0.1215
Leishmania major cysteine peptidase A (CPA) 0.1082 0.2499 0.7349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0294 0.0446 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Entamoeba histolytica cysteine protease, putative 0.1082 0.2499 1
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0446 0.1215
Plasmodium vivax metacaspase 1, putative 0.0456 0.0869 0.2747
Trichomonas vaginalis calcium binding protein, putative 0.0225 0.0266 0.0679
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0521 0.1037 0.1003
Trypanosoma brucei Calpain-like protein 2 0.0385 0.0682 0.1917
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Toxoplasma gondii troponin c, isotype gamma, putative 0.0225 0.0266 0.0783
Leishmania major calmodulin, putative 0.0225 0.0266 0.0783
Echinococcus granulosus calbindin 32 0.023 0.0279 0.0279
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.1122 0.2603 0.2603
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.8999
Giardia lamblia Cysteine protease 0.0294 0.0446 0.1215
Trichomonas vaginalis calmodulin, putative 0.023 0.0279 0.0717
Brugia malayi calpain 5 0.0385 0.0682 0.0647
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1428 0.3401 0.3376
Plasmodium vivax unspecified product 0.0294 0.0446 0.135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0446 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0137 0.0038 0.0038
Echinococcus multilocularis expressed protein 0.0751 0.1637 0.1637
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0294 0.0446 0.0446
Giardia lamblia Cathepsin L precursor 0.0294 0.0446 0.1215
Echinococcus granulosus cathepsin l cysteine peptidase 0.1082 0.2499 0.2499
Echinococcus granulosus cathepsin b 0.3961 1 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0385 0.0682 0.1917
Schistosoma mansoni calcium binding atopy-related autoantigen 0.023 0.0279 0.0279
Onchocerca volvulus Cell death protein 3 homolog 0.0747 0.1625 0.3015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0294 0.0446 0.1215
Toxoplasma gondii cathepsin CPC2 0.0294 0.0446 0.1312
Entamoeba histolytica cysteine protease, putative 0.0294 0.0446 0.166
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.901
Trypanosoma brucei cysteine peptidase C (CPC) 0.1428 0.3401 1
Echinococcus multilocularis programmed cell death protein 0.0229 0.0276 0.0276
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0137 0.0038 0.0111
Leishmania major protein kinase, putative 0.0225 0.0266 0.0783
Echinococcus multilocularis cathepsin b 0.3961 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Brugia malayi Cathepsin L-like precursor 0.0758 0.1656 0.1624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0618 0.129 0.3723
Plasmodium vivax calpain, putative 0.1299 0.3064 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0521 0.1037 0.1003
Giardia lamblia Cysteine protease 0.0294 0.0446 0.1215
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0225 0.0266 0.0928
Trypanosoma cruzi caltractin, putative 0.0225 0.0266 0.0229
Entamoeba histolytica cysteine proteinase 1, putative 0.0618 0.129 0.5086
Echinococcus granulosus acylamino acid releasing enzyme 0.0137 0.0038 0.0038
Giardia lamblia Cathepsin B precursor 0.1428 0.3401 1
Schistosoma mansoni cathepsin F (C01 family) 0.1082 0.2499 0.2499
Toxoplasma gondii centrin 0.0225 0.0266 0.0783
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0294 0.0446 0.1215
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Leishmania major centrin, putative,caltractin, putative 0.0225 0.0266 0.0783
Leishmania major centrin, putative 0.0225 0.0266 0.0783
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0294 0.0446 0.1215
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1299 0.3064 0.3038
Leishmania major cathepsin L-like protease 0.1082 0.2499 0.7349
Trichomonas vaginalis calcium binding protein, putative 0.0229 0.0276 0.0707
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0225 0.0266 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.0038 0.000000011045
Schistosoma mansoni calpain-2 (C02 family) 0.0385 0.0682 0.0682
Giardia lamblia Cathepsin B precursor 0.1428 0.3401 1
Onchocerca volvulus 0.1082 0.2499 0.4675
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1299 0.3064 0.3038
Plasmodium vivax vivapain-2 0.1082 0.2499 0.8133
Leishmania major calmodulin-like protein 0.0225 0.0266 0.0783
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0294 0.0446 0.135
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1172 0.2733 1
Brugia malayi Cell death protein 3 precursor 0.0747 0.1625 0.1594
Echinococcus multilocularis calpain A 0.3687 0.9286 0.9286
Echinococcus granulosus EF HAND 1 calcium binding site 0.0225 0.0266 0.0266
Trichomonas vaginalis calmodulin, putative 0.0225 0.0266 0.0679
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0294 0.0446 0.135
Echinococcus granulosus apoptotic protease activating factor 1 0.029 0.0436 0.0436
Schistosoma mansoni hypothetical protein 0.0225 0.0266 0.0266
Trichomonas vaginalis calmodulin, putative 0.0225 0.0266 0.0679
Echinococcus multilocularis cathepsin L 0.0294 0.0446 0.0446
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0137 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0294 0.0446 0.1215
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0294 0.0446 0.0446
Schistosoma mansoni hypothetical protein 0.0385 0.0682 0.0682
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3457 0.8687 0.8687
Trypanosoma brucei mitochondrial calcium uptake 1 0.0225 0.0266 0.0679
Trypanosoma cruzi cysteine proteinase, putative 0.0618 0.129 0.1257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0446 0.1215
Leishmania major cathepsin L-like protease 0.1177 0.2746 0.8074
Trichomonas vaginalis calmodulin, putative 0.0225 0.0266 0.0679
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0137 0.0038 0.0038
Echinococcus granulosus calpain A 0.3687 0.9286 0.9286
Trichomonas vaginalis calpain, putative 0.0385 0.0682 0.1917
Plasmodium falciparum serine repeat antigen 7 0.0294 0.0446 0.166
Schistosoma mansoni Mername-AA248 (C02 family) 0.1299 0.3064 0.3064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0385 0.0682 0.0647
Giardia lamblia Cathepsin B precursor 0.1428 0.3401 1
Echinococcus multilocularis calcium uptake protein 1 0.023 0.0279 0.0279
Plasmodium vivax unspecified product 0.0324 0.0523 0.1605
Schistosoma mansoni cathepsin s 0.0324 0.0523 0.0523
Toxoplasma gondii hypothetical protein 0.0137 0.0038 0.0111
Trypanosoma brucei prolyl oligopeptidase, putative 0.0521 0.1037 0.297
Plasmodium falciparum serine repeat antigen 3 0.0294 0.0446 0.166
Schistosoma mansoni cathepsin F (C01 family) 0.1082 0.2499 0.2499
Onchocerca volvulus 0.0758 0.1656 0.3073
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0294 0.0446 0.135
Trypanosoma cruzi cruzipain precursor, putative 0.0324 0.0523 0.0488
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3961 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Echinococcus granulosus cathepsin L 0.0618 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.0385 0.0682 0.0647
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1428 0.3401 1
Plasmodium falciparum serine repeat antigen 4 0.0294 0.0446 0.166
Mycobacterium tuberculosis Probable peptidase 0.0521 0.1037 0.3792
Schistosoma mansoni gamma-secretase subunit aph-1 0.0237 0.0298 0.0298
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.0446 0.041
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3961 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0853 0.1903 0.1872
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0385 0.0682 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0618 0.129 0.129
Onchocerca volvulus Cathepsin L homolog 0.1082 0.2499 0.4675
Loa Loa (eye worm) hypothetical protein 0.0225 0.0266 0.0229
Echinococcus multilocularis caspase 2 0.0747 0.1625 0.1625
Leishmania major hypothetical protein, conserved 0.0225 0.0266 0.0783
Trichomonas vaginalis set domain proteins, putative 0.0479 0.0928 0.2648
Echinococcus granulosus gamma secretase subunit aph 1 0.0237 0.0298 0.0298
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0521 0.1037 0.3792
Leishmania major calpain family cysteine protease-like protein 0.0385 0.0682 0.2006
Trypanosoma brucei calpain-like protein, putative 0.1299 0.3064 0.8999
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0294 0.0446 0.166
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3961 1 1
Loa Loa (eye worm) calmodulin-like protein 0.0225 0.0266 0.0229
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0521 0.1037 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0446 0.1215
Loa Loa (eye worm) hypothetical protein 0.0152 0.0076 0.0039
Loa Loa (eye worm) hypothetical protein 0.0294 0.0446 0.041
Schistosoma mansoni centrin-related 0.0225 0.0266 0.0266
Schistosoma mansoni neuronal calcium sensor 0.0225 0.0266 0.0266
Brugia malayi hypothetical protein 0.024 0.0306 0.0269
Brugia malayi cathepsin F-like cysteine proteinase 0.0324 0.0523 0.0488
Brugia malayi Calmodulin-like protein 0.0225 0.0266 0.0229
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Loa Loa (eye worm) calpain D 0.0385 0.0682 0.0647
Onchocerca volvulus 0.0225 0.0266 0.0434
Brugia malayi EF hand family protein 0.023 0.0279 0.0242
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1299 0.3064 0.3038
Trypanosoma cruzi kinesin, putative 0.0914 0.2062 0.2032
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.023 0.0279 0.0242
Brugia malayi Cathepsin L-like cysteine proteinase 0.0758 0.1656 0.1624
Leishmania major cathepsin L-like protease 0.1082 0.2499 0.7349
Leishmania major oligopeptidase b 0.0521 0.1037 0.3048
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0225 0.0266 0.0679
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.0869 0.2472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Echinococcus multilocularis cysteine protease 0.1082 0.2499 0.2499
Giardia lamblia Cathepsin L precursor 0.0294 0.0446 0.1215
Entamoeba histolytica cysteine proteinase, putative 0.0758 0.1656 0.6573
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Echinococcus multilocularis EF hand domain containing family member A2 0.0225 0.0266 0.0266
Leishmania major programmed cell death 6 protein-like protein 0.0225 0.0266 0.0783
Entamoeba histolytica calpain family cysteine protease, putative 0.0385 0.0682 0.2619
Trichomonas vaginalis calpain, putative 0.0385 0.0682 0.1917
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0225 0.0266 0.0266
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0385 0.0682 0.2006
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Trypanosoma cruzi conserved protein 0.0385 0.0682 0.0647
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.901
Echinococcus multilocularis centrin 2 0.0225 0.0266 0.0266
Brugia malayi hypothetical protein 0.0152 0.0076 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0446 0.1215
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Entamoeba histolytica cysteine proteinase, putative 0.1082 0.2499 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Plasmodium falciparum cysteine proteinase falcipain 3 0.1082 0.2499 1
Leishmania major calmodulin, putative 0.0225 0.0266 0.0783
Echinococcus granulosus cathepsin l1 0.1082 0.2499 0.2499
Trypanosoma cruzi calmodulin, putative 0.0225 0.0266 0.0229
Trypanosoma brucei protein I/6 0.0225 0.0266 0.0679
Echinococcus granulosus cathepsin L cysteine proteinase 0.1082 0.2499 0.2499
Schistosoma mansoni caspase-3 (C14 family) 0.1122 0.2603 0.2603
Loa Loa (eye worm) calpain 0.1299 0.3064 0.3038
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0385 0.0682 0.1917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Schistosoma mansoni caspase-7 (C14 family) 0.0747 0.1625 0.1625
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0385 0.0682 0.0647
Giardia lamblia Cathepsin B precursor 0.0294 0.0446 0.1215
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0294 0.0446 0.135
Trypanosoma brucei antigen, putative 0.1299 0.3064 0.8999
Plasmodium falciparum serine repeat antigen 9 0.0294 0.0446 0.166
Trypanosoma brucei calmodulin, putative 0.023 0.0279 0.0717
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Entamoeba histolytica grainin 2 0.0229 0.0276 0.0966
Echinococcus granulosus calpain 0.1299 0.3064 0.3064
Echinococcus granulosus calmodulin 0.0225 0.0266 0.0266
Trypanosoma brucei centrin, putative 0.0225 0.0266 0.0679
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Trichomonas vaginalis calcium binding protein, putative 0.0225 0.0266 0.0679
Loa Loa (eye worm) EF hand family protein 0.0225 0.0266 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0618 0.129 0.5086
Entamoeba histolytica cysteine protease, putative 0.0294 0.0446 0.166
Brugia malayi Cathepsin L-like precursor 0.1082 0.2499 0.2471
Trypanosoma cruzi prolyl endopeptidase 0.1309 0.3091 0.3065
Trypanosoma cruzi cysteine peptidase, putative 0.1177 0.2746 0.2719
Echinococcus multilocularis caspase 8 0.0456 0.0869 0.0869
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0137 0.0038 0.0111
Echinococcus multilocularis hypothetical protein 0.1299 0.3064 0.3064
Loa Loa (eye worm) hypothetical protein 0.0294 0.0446 0.041
Brugia malayi Papain family cysteine protease containing protein 0.1082 0.2499 0.2471
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0385 0.0682 0.0647
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1428 0.3401 0.3401
Trichomonas vaginalis calcium binding proteins, putative 0.0225 0.0266 0.0679
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Echinococcus granulosus caspase 0.1122 0.2603 0.2603
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Trichomonas vaginalis calcineurin B subunit, putative 0.023 0.0279 0.0717
Leishmania major hypothetical protein, unknown function 0.0385 0.0682 0.2006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0618 0.129 0.129
Entamoeba histolytica cysteine proteinase, putative 0.1082 0.2499 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0294 0.0446 0.135
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0294 0.0446 0.0446
Onchocerca volvulus 0.1082 0.2499 0.4675
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0294 0.0446 0.041
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0385 0.0682 0.0647
Echinococcus granulosus cathepsin b 0.3961 1 1
Giardia lamblia Cathepsin B precursor 0.0294 0.0446 0.1215
Brugia malayi calcium-binding protein 0.0225 0.0266 0.0229
Trypanosoma cruzi cysteine peptidase, putative 0.0618 0.129 0.1257
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0618 0.129 0.1257
Giardia lamblia Cathepsin L precursor 0.0294 0.0446 0.1215
Trichomonas vaginalis calmodulin, putative 0.0225 0.0266 0.0679
Entamoeba histolytica cysteine protease, putative 0.0294 0.0446 0.166
Giardia lamblia Cathepsin L precursor 0.0294 0.0446 0.1215
Trypanosoma brucei calpain-like protein, putative 0.1299 0.3064 0.8999
Echinococcus multilocularis programmed cell death protein 0.0229 0.0276 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.0869 0.2472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Echinococcus granulosus cathepsin L cysteine protease 0.0618 0.129 0.129
Giardia lamblia Cysteine protease 0.0294 0.0446 0.1215
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.1122 0.2603 0.2603
Trypanosoma cruzi cysteine peptidase, putative 0.0324 0.0523 0.0488
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0294 0.0446 0.1215
Loa Loa (eye worm) programmed cell death protein 6 0.023 0.0279 0.0242
Schistosoma mansoni neuronal calcium sensor 0.0225 0.0266 0.0266
Onchocerca volvulus 0.1082 0.2499 0.4675
Loa Loa (eye worm) hypothetical protein 0.0456 0.0869 0.0834
Entamoeba histolytica calpain large subunit domain III containing protein 0.0914 0.2062 0.8223
Onchocerca volvulus Cathepsin F homolog 0.1082 0.2499 0.4675
Plasmodium vivax vivapain-1 0.0618 0.129 0.4137
Schistosoma mansoni neuronal calcium sensor 0.0225 0.0266 0.0266
Entamoeba histolytica calcium-binding protein, putative 0.0225 0.0266 0.0928
Trypanosoma brucei centrin, putative 0.0225 0.0266 0.0679
Echinococcus granulosus Dipeptidyl peptidase 9 0.0137 0.0038 0.0038
Brugia malayi cathepsin F-like cysteine proteinase 0.0294 0.0446 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0294 0.0446 0.1215
Trypanosoma cruzi kinesin, putative 0.0914 0.2062 0.2032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0137 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0294 0.0446 0.135
Brugia malayi calpain family protein 1 0.3457 0.8687 0.8682
Loa Loa (eye worm) calpain family protein 1 0.3457 0.8687 0.8682
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0385 0.0682 0.1917
Plasmodium falciparum calpain 0.0385 0.0682 0.2619
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0225 0.0266 0.0266
Trypanosoma brucei calmodulin, putative 0.0225 0.0266 0.0679
Schistosoma mansoni calpain-7 (C02 family) 0.1299 0.3064 0.3064
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.0869 0.2472
Entamoeba histolytica calmodulin, putative 0.0225 0.0266 0.0928
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1082 0.2499 0.2499
Trypanosoma brucei Calpain-like protein 1.1 0.0385 0.0682 0.1917
Giardia lamblia Hypothetical protein 0.0294 0.0446 0.1215
Leishmania major hypothetical protein, conserved 0.0385 0.0682 0.2006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0294 0.0446 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.129 0.3723
Leishmania major cathepsin L-like protease 0.1082 0.2499 0.7349
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.0446 0.041
Leishmania major calmodulin-like protein 0.0225 0.0266 0.0783
Trypanosoma brucei calpain-like protein, putative 0.1299 0.3064 0.8999
Trichomonas vaginalis centrin, putative 0.0225 0.0266 0.0679
Echinococcus multilocularis cathepsin L cysteine protease 0.1082 0.2499 0.2499
Schistosoma mansoni calpain (C02 family) 0.1299 0.3064 0.3064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0446 0.1215
Trypanosoma brucei metacaspase 5, putative 0.0456 0.0869 0.2472
Trypanosoma brucei Calpain-like protein CALP1.3 0.0385 0.0682 0.1917
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0456 0.0869 0.0869
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0385 0.0682 0.0647
Echinococcus granulosus survival motor neuron protein 1 0.024 0.0306 0.0306
Trypanosoma cruzi cruzipain precursor, putative 0.1177 0.2746 0.2719
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0521 0.1037 0.297
Loa Loa (eye worm) hypothetical protein 0.1309 0.3091 0.3065
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Loa Loa (eye worm) cathepsin B 0.1428 0.3401 0.3376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Echinococcus multilocularis prolyl endopeptidase 0.1309 0.3091 0.3091
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1082 0.2499 0.2471
Trypanosoma brucei Metacaspase-4 0.0456 0.0869 0.2472
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0385 0.0682 0.1917
Entamoeba histolytica cysteine protease, putative 0.0294 0.0446 0.166
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0324 0.0523 0.0488
Echinococcus granulosus EF hand domain containing family member A2 0.0225 0.0266 0.0266
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Entamoeba histolytica cysteine protease, putative 0.0294 0.0446 0.166
Loa Loa (eye worm) hypothetical protein 0.2158 0.5303 0.5285
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0137 0.0038 0.0038
Schistosoma mansoni reticulocalbin 0.023 0.0279 0.0279
Plasmodium vivax serine-repeat antigen (SERA) 0.0294 0.0446 0.135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Trichomonas vaginalis calmodulin, putative 0.0225 0.0266 0.0679
Brugia malayi cathepsin Z-like cysteine proteinase 0.0294 0.0446 0.041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0294 0.0446 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3682 0.9273 0.9273
Echinococcus multilocularis microtubule associated protein 2 0.1389 0.3299 0.3299
Loa Loa (eye worm) hypothetical protein 0.0225 0.0266 0.0229
Leishmania major cathepsin L-like protease 0.1082 0.2499 0.7349
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0294 0.0446 0.0446
Trypanosoma brucei calpain, putative 0.0385 0.0682 0.1917
Brugia malayi Cathepsin L-like precursor 0.0758 0.1656 0.1624
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0294 0.0446 0.0446
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.3038
Brugia malayi cathepsin Z-like cysteine proteinase 0.0294 0.0446 0.041
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0385 0.0682 0.0647
Echinococcus multilocularis gamma secretase subunit aph 1 0.0237 0.0298 0.0298
Onchocerca volvulus 0.1082 0.2499 0.4675
Loa Loa (eye worm) hypothetical protein 0.0758 0.1656 0.1624
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.0869 0.2472
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.1917
Trypanosoma cruzi cysteine peptidase, putative 0.1082 0.2499 0.2471
Brugia malayi cathepsin L-like cysteine proteinase 0.0294 0.0446 0.041
Trichomonas vaginalis myosin light chain 1, putative 0.0225 0.0266 0.0679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.129 0.3723
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1082 0.2499 1
Echinococcus multilocularis caspase 0.1122 0.2603 0.2603
Brugia malayi hypothetical protein 0.029 0.0436 0.04
Giardia lamblia Cathepsin B precursor 0.0294 0.0446 0.1215
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0324 0.0523 0.0488
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0294 0.0446 0.135
Brugia malayi Pre-SET motif family protein 0.0421 0.0777 0.0742
Loa Loa (eye worm) hypothetical protein 0.029 0.0436 0.04
Loa Loa (eye worm) ctsf protein 0.1082 0.2499 0.2471
Echinococcus multilocularis tumor protein p63 0.034 0.0566 0.0566
Trypanosoma brucei centrin-3 0.0229 0.0276 0.0707
Giardia lamblia Hypothetical protein 0.0294 0.0446 0.1215
Plasmodium falciparum cysteine proteinase falcipain 1 0.0618 0.129 0.5086
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0294 0.0446 0.135
Brugia malayi Papain family cysteine protease containing protein 0.0618 0.129 0.1257
Trypanosoma cruzi I/6 autoantigen, putative 0.0225 0.0266 0.0229
Onchocerca volvulus 0.1082 0.2499 0.4675
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0294 0.0446 0.166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Echinococcus multilocularis cysteine protease 0.1082 0.2499 0.2499
Echinococcus granulosus tumor protein p63 0.034 0.0566 0.0566
Entamoeba histolytica cysteine proteinase, putative 0.0618 0.129 0.5086
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0294 0.0446 0.041
Entamoeba histolytica cysteine proteinase 2 0.0618 0.129 0.5086
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.3038
Giardia lamblia Cathepsin B precursor 0.0294 0.0446 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0294 0.0446 0.1215
Loa Loa (eye worm) cysteine protease 0.1082 0.2499 0.2471
Trypanosoma brucei cysteine peptidase, putative 0.0385 0.0682 0.1917
Schistosoma mansoni cathepsin S (C01 family) 0.0294 0.0446 0.0446
Echinococcus multilocularis apoptotic protease activating factor 1 0.029 0.0436 0.0436
Schistosoma mansoni ef hand domain family member A2 0.0225 0.0266 0.0266
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0385 0.0682 0.0647
Trypanosoma brucei metacaspase 0.0456 0.0869 0.2472
Trypanosoma cruzi centrin, putative 0.0229 0.0276 0.0239
Trypanosoma cruzi calmodulin, putative 0.0225 0.0266 0.0229
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0385 0.0682 0.1917
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1309 0.3091 0.9089
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0225 0.0266 0.0229
Echinococcus granulosus cathepsin l1 0.0758 0.1656 0.1656
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0385 0.0682 0.0647
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0385 0.0682 0.1917
Schistosoma mansoni reticulocalbin 0.0225 0.0266 0.0266
Schistosoma mansoni cathepsin F (C01 family) 0.0758 0.1656 0.1656
Trichomonas vaginalis calcium binding protein, putative 0.0225 0.0266 0.0679
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3682 0.9273 0.9273
Leishmania major kinesin, putative 0.0914 0.2062 0.6063
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1299 0.3064 0.3038
Brugia malayi fibroinase precursor 0.0294 0.0446 0.041
Leishmania major cathepsin L-like protease 0.1177 0.2746 0.8074
Brugia malayi Cathepsin L-like precursor 0.1082 0.2499 0.2471
Echinococcus multilocularis calumenin 0.023 0.0279 0.0279
Plasmodium vivax vivapain-2 0.1082 0.2499 0.8133
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0294 0.0446 0.135
Trichomonas vaginalis calmodulin, putative 0.0229 0.0276 0.0707
Schistosoma mansoni cathepsin C 0.0294 0.0446 0.0446
Brugia malayi Cathepsin L-like precursor 0.1082 0.2499 0.2471
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1299 0.3064 0.8999
Loa Loa (eye worm) hypothetical protein 0.3457 0.8687 0.8682
Onchocerca volvulus 0.029 0.0436 0.0757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Loa Loa (eye worm) fibroinase 0.1082 0.2499 0.2471
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0385 0.0682 0.1917
Trypanosoma cruzi cysteine peptidase, putative 0.1177 0.2746 0.2719
Plasmodium falciparum serine repeat antigen 6 0.0294 0.0446 0.166
Echinococcus multilocularis EF hand domain containing family member A2 0.023 0.0279 0.0279
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0225 0.0266 0.0679
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Trichomonas vaginalis conserved hypothetical protein 0.0225 0.0266 0.0679
Giardia lamblia Cathepsin L-like protease 0.0294 0.0446 0.1215
Loa Loa (eye worm) hypothetical protein 0.0294 0.0446 0.041
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0137 0.0038 0.0111
Onchocerca volvulus Prolyl endopeptidase homolog 0.1309 0.3091 0.5799
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.0869 0.2472
Schistosoma mansoni calmodulin 0.0225 0.0266 0.0266
Echinococcus granulosus prolyl endopeptidase 0.1309 0.3091 0.3091
Plasmodium falciparum serine repeat antigen 2 0.0294 0.0446 0.166
Echinococcus multilocularis acylamino acid releasing enzyme 0.0137 0.0038 0.0038
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0521 0.1037 0.5
Plasmodium falciparum serine repeat antigen 8 0.0294 0.0446 0.166
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0137 0.0038 0.0038
Echinococcus granulosus programmed cell death protein 0.0229 0.0276 0.0276
Onchocerca volvulus 0.0479 0.0929 0.1693
Entamoeba histolytica hypothetical protein, conserved 0.023 0.0279 0.0979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Plasmodium falciparum serine repeat antigen 1 0.0294 0.0446 0.166
Echinococcus granulosus caspase 3 0.0665 0.1414 0.1414
Plasmodium falciparum centrin-1 0.0225 0.0266 0.0928
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.0446 0.1215
Echinococcus multilocularis cathepsin b 0.3961 1 1
Trypanosoma cruzi metacaspase 5, putative 0.0456 0.0869 0.0834
Toxoplasma gondii EF hand domain-containing protein 0.0225 0.0266 0.0783
Echinococcus multilocularis calpain 7 (C02 family) 0.1299 0.3064 0.3064
Trypanosoma cruzi metacaspase, putative 0.0456 0.0869 0.0834
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1299 0.3064 0.3038
Onchocerca volvulus 0.2158 0.5303 1
Trypanosoma cruzi cysteine proteinase, putative 0.0618 0.129 0.1257
Giardia lamblia Cathepsin B precursor 0.0294 0.0446 0.1215
Toxoplasma gondii calcium-dependent protein kinase 0.023 0.0279 0.082
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0225 0.0266 0.0928
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Loa Loa (eye worm) hypothetical protein 0.3072 0.7685 0.7676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0446 0.1215
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Entamoeba histolytica grainin, putative 0.023 0.0279 0.0979
Schistosoma mansoni microtubule-associated protein tau 0.1389 0.3299 0.3299
Schistosoma mansoni cathepsin B (C01 family) 0.0294 0.0446 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.1917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0521 0.1037 0.3048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3961 1 1
Toxoplasma gondii cathepsin CPC1 0.0294 0.0446 0.1312
Leishmania major cathepsin L-like protease 0.1177 0.2746 0.8074
Schistosoma mansoni memapsin-2 (A01 family) 0.0433 0.0809 0.0809
Toxoplasma gondii prolyl endopeptidase 0.1309 0.3091 0.9089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Plasmodium vivax serine-repeat antigen (SERA) 0.0294 0.0446 0.135
Trypanosoma brucei caltractin, putative 0.0229 0.0276 0.0707
Leishmania major metacaspase, putative 0.0456 0.0869 0.2555
Trypanosoma brucei Component of motile flagella 41 0.0225 0.0266 0.0679
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0225 0.0266 0.0266
Echinococcus multilocularis cathepsin L 0.0618 0.129 0.129
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1299 0.3064 0.3038
Trichomonas vaginalis centrin, putative 0.0225 0.0266 0.0679
Trypanosoma brucei metacaspase MCA2 0.0456 0.0869 0.2472
Schistosoma mansoni mitochondrial solute carrier 0.0225 0.0266 0.0266
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Schistosoma mansoni calpain C (C02 family) 0.1299 0.3064 0.3064
Trypanosoma brucei metacaspase MCA3 0.0456 0.0869 0.2472
Plasmodium falciparum metacaspase 1 0.0456 0.0869 0.3377
Echinococcus granulosus EF hand domain containing family member A2 0.023 0.0279 0.0279
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0456 0.0869 0.2555
Onchocerca volvulus 0.0152 0.0076 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0618 0.129 0.5086
Echinococcus multilocularis calmodulin 0.0225 0.0266 0.0266
Trypanosoma cruzi centrin, putative 0.0229 0.0276 0.0239
Leishmania major hypothetical protein, conserved 0.023 0.0279 0.082
Brugia malayi EF hand family protein 0.0225 0.0266 0.0229
Echinococcus multilocularis caspase 3 0.0665 0.1414 0.1414
Schistosoma mansoni calmodulin 0.0225 0.0266 0.0266
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Schistosoma mansoni hypothetical protein 0.0225 0.0266 0.0266
Trypanosoma cruzi calmodulin, putative 0.0225 0.0266 0.0229
Trichomonas vaginalis calmodulin, putative 0.0225 0.0266 0.0679
Loa Loa (eye worm) hypothetical protein 0.0324 0.0523 0.0488
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1082 0.2499 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.0446 0.041
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0294 0.0446 0.135
Schistosoma mansoni centrin 0.0225 0.0266 0.0266
Giardia lamblia Cathepsin L precursor 0.0294 0.0446 0.1215
Echinococcus granulosus expressed protein 0.0751 0.1637 0.1637
Giardia lamblia Hypothetical protein 0.023 0.0279 0.0717
Brugia malayi Cathepsin L-like precursor 0.1082 0.2499 0.2471
Onchocerca volvulus 0.1082 0.2499 0.4675
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.901
Toxoplasma gondii EFHC1, putative 0.0225 0.0266 0.0783
Trypanosoma cruzi oligopeptidase b 0.0521 0.1037 0.1003
Trypanosoma cruzi I/6 autoantigen, putative 0.0225 0.0266 0.0229
Trypanosoma brucei I/6 autoantigen 0.0225 0.0266 0.0679
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Echinococcus multilocularis calmodulin 0.0225 0.0266 0.0266
Giardia lamblia Cathepsin L precursor 0.0294 0.0446 0.1215
Entamoeba histolytica hypothetical protein 0.0294 0.0446 0.166
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0137 0.0038 0.0038
Echinococcus multilocularis calpain 0.1299 0.3064 0.3064
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0225 0.0266 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.1917
Schistosoma mansoni neuronal calcium sensor 0.0225 0.0266 0.0266
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3682 0.9273 0.9273
Giardia lamblia Cysteine protease 0.0294 0.0446 0.1215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Brugia malayi Cathepsin L-like precursor 0.1082 0.2499 0.2471
Schistosoma mansoni hypothetical protein 0.029 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.024 0.0306 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1082 0.2499 0.7319
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.0777 0.0742
Echinococcus granulosus caspase 2 0.0747 0.1625 0.1625
Echinococcus granulosus cathepsin L 0.0294 0.0446 0.0446
Loa Loa (eye worm) hypothetical protein 0.0747 0.1625 0.1594
Schistosoma mansoni calmodulin related calcium binding protein 0.0225 0.0266 0.0266
Brugia malayi gamma-secretase subunit aph-1 0.0237 0.0298 0.0261
Entamoeba histolytica calmodulin, putative 0.0225 0.0266 0.0928
Toxoplasma gondii cathepsin B 0.1428 0.3401 1
Trichomonas vaginalis hypothetical protein 0.0385 0.0682 0.1917
Trypanosoma cruzi centrin-3 0.0229 0.0276 0.0239
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0618 0.129 0.129
Trypanosoma cruzi major cysteine proteinase, putative 0.0294 0.0446 0.041
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0225 0.0266 0.0266
Entamoeba histolytica cysteine protease, putative 0.0294 0.0446 0.166
Leishmania major calcineurin B subunit, putative 0.0225 0.0266 0.0783
Brugia malayi prolyl oligopeptidase family protein 0.1309 0.3091 0.3065
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.0306 0.0306
Toxoplasma gondii centrin, putative 0.0225 0.0266 0.0783
Trypanosoma cruzi oligopeptidase b 0.0521 0.1037 0.1003
Echinococcus granulosus centrin 2 0.0225 0.0266 0.0266
Entamoeba histolytica protein kinase, putative 0.0914 0.2062 0.8223
Brugia malayi calpain family protein 1 0.3457 0.8687 0.8682
Trypanosoma cruzi cysteine protease, putative 0.0618 0.129 0.1257
Trypanosoma cruzi metacaspase, putative 0.0456 0.0869 0.0834
Giardia lamblia Cathepsin L-like protease 0.0294 0.0446 0.1215
Trypanosoma brucei calpain-like protein, putative 0.1299 0.3064 0.8999
Onchocerca volvulus Cathepsin L homolog 0.1082 0.2499 0.4675
Toxoplasma gondii preprocathepsin c precursor, putative 0.0294 0.0446 0.1312
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1082 0.2499 0.2471
Onchocerca volvulus 0.1082 0.2499 0.4675
Schistosoma mansoni caspase-7 (C14 family) 0.1122 0.2603 0.2603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0456 0.0869 0.0834
Entamoeba histolytica calcium binding family protein 0.0225 0.0266 0.0928
Onchocerca volvulus 0.0294 0.0446 0.0776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0446 0.1215
Echinococcus multilocularis calpain 5 0.1299 0.3064 0.3064
Leishmania major centrin, putative 0.0225 0.0266 0.0783
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1082 0.2499 0.7319
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0225 0.0266 0.0229
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0456 0.0869 0.2555
Entamoeba histolytica cysteine proteinase, putative 0.0618 0.129 0.5086
Trypanosoma cruzi metacaspase, putative 0.0456 0.0869 0.0834
Echinococcus multilocularis calbindin 32 0.023 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0294 0.0446 0.1215
Echinococcus granulosus calpain A 0.1299 0.3064 0.3064
Leishmania major calpain protease-like protein 0.0385 0.0682 0.2006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0294 0.0446 0.0446
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Brugia malayi calpain D 0.0385 0.0682 0.0647
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.0038 0.000000011045
Echinococcus granulosus calpain 7 C02 family 0.1299 0.3064 0.3064
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0294 0.0446 0.166
Schistosoma mansoni rab 0.0225 0.0266 0.0266
Brugia malayi Cathepsin L-like precursor 0.1082 0.2499 0.2471
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Plasmodium vivax centrin-1, putative 0.0225 0.0266 0.0755
Echinococcus granulosus caspase 8 0.0456 0.0869 0.0869
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0456 0.0869 0.2472
Plasmodium vivax hypothetical protein, conserved 0.0456 0.0869 0.2747
Plasmodium vivax unspecified product 0.0618 0.129 0.4137
Leishmania major i/6 autoantigen-like protein 0.0225 0.0266 0.0783
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0225 0.0266 0.0229
Loa Loa (eye worm) calpain family protein 1 0.2543 0.6305 0.6291
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1082 0.2499 0.2499
Loa Loa (eye worm) hypothetical protein 0.0294 0.0446 0.041
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0225 0.0266 0.0755
Echinococcus multilocularis calpain family protein 1, d 0.2543 0.6305 0.6305
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1309 0.3091 0.3091
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Trypanosoma brucei prolyl endopeptidase 0.1309 0.3091 0.9078
Echinococcus granulosus cysteine protease 0.0618 0.129 0.129
Trypanosoma cruzi metacaspase 5, putative 0.0456 0.0869 0.0834
Brugia malayi Papain family cysteine protease containing protein 0.0618 0.129 0.1257
Trichomonas vaginalis calmodulin-2, putative 0.0225 0.0266 0.0679
Trypanosoma brucei oligopeptidase b 0.0521 0.1037 0.297
Entamoeba histolytica cysteine protease, putative 0.0618 0.129 0.5086
Loa Loa (eye worm) hypothetical protein 0.3961 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0294 0.0446 0.1215
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.3038
Leishmania major cathepsin L-like protease 0.1082 0.2499 0.7349
Trichomonas vaginalis conserved hypothetical protein 0.0456 0.0869 0.2472
Plasmodium vivax vivapain-3 0.0618 0.129 0.4137
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0385 0.0682 0.1917
Trichomonas vaginalis calpain, putative 0.0385 0.0682 0.1917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0446 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Echinococcus granulosus microtubule associated protein 2 0.1389 0.3299 0.3299
Trypanosoma brucei calpain, putative 0.0385 0.0682 0.1917
Loa Loa (eye worm) hypothetical protein 0.0294 0.0446 0.041
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0237 0.0298 0.0261
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1309 0.3091 0.3091
Trypanosoma brucei hypothetical protein, conserved 0.0225 0.0266 0.0679
Loa Loa (eye worm) hypothetical protein 0.0758 0.1656 0.1624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Schistosoma mansoni calpain-7 (C02 family) 0.1299 0.3064 0.3064
Echinococcus granulosus neurocalcin 0.0225 0.0266 0.0266
Echinococcus granulosus calcium uptake protein 1 0.023 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1082 0.2499 0.7319
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0294 0.0446 0.1215
Brugia malayi cathepsin L precursor 0.0294 0.0446 0.041
Loa Loa (eye worm) hypothetical protein 0.0324 0.0523 0.0488
Onchocerca volvulus 0.023 0.0279 0.0458
Toxoplasma gondii cathepsin CPL 0.1082 0.2499 0.7349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Trypanosoma brucei kinesin, putative 0.0914 0.2062 0.6018
Toxoplasma gondii hypothetical protein 0.0385 0.0682 0.2006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0294 0.0446 0.166
Trypanosoma cruzi major cysteine proteinase, putative 0.0389 0.0693 0.0658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Plasmodium vivax hypothetical protein, conserved 0.023 0.0279 0.0796
Echinococcus granulosus calpain 5 0.1299 0.3064 0.3064
Echinococcus granulosus calumenin 0.023 0.0279 0.0279
Plasmodium falciparum metacaspase-like protein 0.0456 0.0869 0.3377
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0446 0.1215
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0294 0.0446 0.0446
Onchocerca volvulus 0.0225 0.0266 0.0434
Echinococcus multilocularis neurocalcin 0.0225 0.0266 0.0266
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0294 0.0446 0.1215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1177 0.2746 0.8052
Loa Loa (eye worm) hypothetical protein 0.0324 0.0523 0.0488
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0294 0.0446 0.166
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0225 0.0266 0.0679
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0618 0.129 0.3723
Toxoplasma gondii calmodulin CAM1 0.023 0.0279 0.082
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.0446 0.041
Brugia malayi calpain 7 0.1299 0.3064 0.3038
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1428 0.3401 1
Brugia malayi Cathepsin L-like precursor 0.0324 0.0523 0.0488
Loa Loa (eye worm) hypothetical protein 0.1082 0.2499 0.2471
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0385 0.0682 0.1917
Trypanosoma cruzi metacaspase, putative 0.0456 0.0869 0.0834
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Echinococcus multilocularis cathepsin L cysteine protease 0.1082 0.2499 0.2499
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.2006
Trichomonas vaginalis calmodulin, putative 0.0225 0.0266 0.0679
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0385 0.0682 0.0647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3961 1 1
Echinococcus multilocularis neuronal calcium sensor 0.0225 0.0266 0.0266
Brugia malayi calpain 5 0.0914 0.2062 0.2032
Plasmodium falciparum serine repeat antigen 5 0.0294 0.0446 0.166
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0294 0.0446 0.041
Leishmania major phospholipase c-like protein 0.0225 0.0266 0.0783
Echinococcus granulosus neuronal calcium sensor 0.0225 0.0266 0.0266
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0225 0.0266 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0758 0.1656 0.4811
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1299 0.3064 0.3038
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0385 0.0682 0.0647
Trypanosoma cruzi cysteine peptidase, putative 0.1177 0.2746 0.2719
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0385 0.0682 0.1917
Loa Loa (eye worm) hypothetical protein 0.0758 0.1656 0.1624
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0456 0.0869 0.2555
Loa Loa (eye worm) hypothetical protein 0.2543 0.6305 0.6291
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3682 0.9273 0.9273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1082 0.2499 0.7319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0758 0.1656 0.4811
Brugia malayi cathepsin L-like precursor 0.0758 0.1656 0.1624
Loa Loa (eye worm) calpain 5 0.0914 0.2062 0.2032
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0294 0.0446 0.1215
Trichomonas vaginalis calcineurin B subunit, putative 0.0225 0.0266 0.0679
Trypanosoma brucei hypothetical protein 0.0385 0.0682 0.1917
Trichomonas vaginalis conserved hypothetical protein 0.0225 0.0266 0.0679

Activities

Activity type Activity value Assay description Source Reference
RBA (binding) 0 Binding affinity against estrogen receptor was determined by using [3H]-estradiol as radioligand in competitive radiometric binding assay ChEMBL. 9873709
RBA (binding) = 0.82 Binding affinity against estrogen receptor was determined by using [3H]-estradiol as radioligand in competitive radiometric binding assay ChEMBL. 9873709

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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