TDR Targets

Basic information

Technical information

TDR Targets ID: 327466
Name: (1R,2R,3R,5R,6R)-2-amino-3-cyclopentyloxy-6-f luorobicyclo[3.1.0]hexane-2,6-dicarboxylic ac id
MW: 287.284 | Formula: C13H18FNO5
H donors: 3 H acceptors: 4 LogP: -2.14 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)[C@]1(N)[C@H](OC2CCCC2)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O
InChi: 1S/C13H18FNO5/c14-12(10(16)17)7-5-8(20-6-3-1-2-4-6)13(15,9(7)12)11(18)19/h6-9H,1-5,15H2,(H,16,17)(H,18,19)/t7-,8-,9+,12-,13+/m1/s1
InChiKey: OQCWNVPJUJCZIF-OAEYFNCWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(1R,2R,3R,5R,6R)-2-amino-3-(cyclopentoxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
(1R,2R,3R,5R,6R)-2-amino-3-(cyclopentoxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
(1R,2R,3R,5R,6R)-2-azanyl-3-cyclopentyloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Metabotropic glutamate receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Metabotropic glutamate receptor 2	872 aa	774 aa	20.4 %
Schistosoma mansoni	metabotropic glutamate receptor	Metabotropic glutamate receptor 2	872 aa	892 aa	26.9 %
Onchocerca volvulus	Golgi-associated plant pathogenesis-related protein 1 homolog	Metabotropic glutamate receptor 2	872 aa	884 aa	35.3 %
Loa Loa (eye worm)	hypothetical protein	Metabotropic glutamate receptor 2	872 aa	822 aa	21.2 %
Onchocerca volvulus	Cell death abnormality protein 8 homolog	Metabotropic glutamate receptor 2	872 aa	883 aa	43.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Echinococcus granulosus	neurocalcin	0.0138	0.0239	0.0239
Schistosoma mansoni	hypothetical protein	0.033	0.0789	0.0789
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0079	0.0069	0.0069
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trichomonas vaginalis	centrin, putative	0.0138	0.0239	0.0303
Trypanosoma cruzi	conserved protein	0.033	0.0789	0.0653
Toxoplasma gondii	calcium-dependent protein kinase	0.0139	0.024	0.0308
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Plasmodium vivax	centrin-1, putative	0.0138	0.0239	0.0325
Echinococcus multilocularis	cathepsin L	0.0106	0.0146	0.0146
Brugia malayi	Papain family cysteine protease containing protein	0.0106	0.0146	0.0146
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.033	0.0789	0.2111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trypanosoma cruzi	caltractin, putative	0.0138	0.0239	0.0094
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Echinococcus multilocularis	calbindin 32	0.0139	0.024	0.024
Loa Loa (eye worm)	calmodulin-like protein	0.0138	0.0239	0.0211
Schistosoma mansoni	neuronal calcium sensor	0.0138	0.0239	0.0239
Loa Loa (eye worm)	ctsf protein	0.0106	0.0146	0.0118
Echinococcus multilocularis	calpain	0.1097	0.2995	0.2995
Schistosoma mansoni	calmodulin	0.0138	0.0239	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0138	0.0239	0.0303
Onchocerca volvulus		0.0139	0.024	0.0191
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.033	0.0789	0.0653
Loa Loa (eye worm)	fibroinase	0.0106	0.0146	0.0118
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0106	0.0146	0.0146
Loa Loa (eye worm)	cathepsin B	0.1166	0.3194	0.3174
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0106	0.0146	0.0146
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Echinococcus multilocularis	cathepsin b	0.3533	1	1
Leishmania major	hypothetical protein, conserved	0.0138	0.0239	0.0303
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0106	0.0146	0.0146
Echinococcus granulosus	calumenin	0.0139	0.024	0.024
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0106	0.0146	0.0146
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0106	0.0146	0.0146
Schistosoma mansoni	cathepsin F (C01 family)	0.0106	0.0146	0.0146
Entamoeba histolytica	grainin 2	0.0138	0.0239	0.0487
Giardia lamblia	Cathepsin B precursor	0.1166	0.3194	1
Schistosoma mansoni	calpain-7 (C02 family)	0.1097	0.2995	0.2995
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.2891
Leishmania major	calpain family cysteine protease-like protein	0.033	0.0789	0.2111
Schistosoma mansoni	neuronal calcium sensor	0.0138	0.0239	0.0239
Trypanosoma brucei	centrin, putative	0.0138	0.0239	0.0303
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.3045	0.8598	0.8598
Echinococcus multilocularis	programmed cell death protein	0.0138	0.0239	0.0239
Trypanosoma brucei	hypothetical protein	0.033	0.0789	0.2111
Echinococcus multilocularis	cathepsin b	0.3533	1	1
Echinococcus granulosus	calpain 5	0.1097	0.2995	0.2995
Toxoplasma gondii	centrin, putative	0.0138	0.0239	0.0303
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	calpain-2 (C02 family)	0.033	0.0789	0.0789
Onchocerca volvulus		0.0138	0.0239	0.0189
Echinococcus multilocularis	calmodulin	0.0138	0.0239	0.0239
Loa Loa (eye worm)	calpain	0.1097	0.2995	0.2975
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.033	0.0789	0.2111
Loa Loa (eye worm)	hypothetical protein	0.2907	0.8201	0.8196
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0767	0.2047	1
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0139	0.024	0.024
Schistosoma mansoni	ef hand domain family member A2	0.0138	0.0239	0.0239
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0138	0.0239	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Brugia malayi	cathepsin L precursor	0.0106	0.0146	0.0146
Plasmodium falciparum	calpain	0.033	0.0789	1
Giardia lamblia	Cathepsin B precursor	0.1166	0.3194	1
Loa Loa (eye worm)	hypothetical protein	0.033	0.0789	0.0763
Leishmania major	calpain protease-like protein	0.033	0.0789	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0239	0.0211
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0106	0.0146	0.0146
Trichomonas vaginalis	calcineurin B subunit, putative	0.0139	0.024	0.0308
Trypanosoma brucei	calpain-like protein, putative	0.1097	0.2995	0.9347
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0139	0.024	0.0095
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1097	0.2995	0.2891
Leishmania major	calmodulin, putative	0.0138	0.0239	0.0303
Toxoplasma gondii	cathepsin B	0.1166	0.3194	1
Echinococcus granulosus	calpain A	0.1097	0.2995	0.2995
Leishmania major	programmed cell death 6 protein-like protein	0.0138	0.0239	0.0303
Trypanosoma brucei	Calpain-like protein 2	0.033	0.0789	0.2111
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0138	0.0239	0.0303
Trypanosoma brucei	hypothetical protein, conserved	0.0138	0.0239	0.0303
Echinococcus granulosus	calpain A	0.3046	0.8599	0.8599
Brugia malayi	calcium-binding protein	0.0138	0.0239	0.0238
Trypanosoma brucei	calpain, putative	0.033	0.0789	0.2111
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1097	0.2995	0.2891
Trichomonas vaginalis	calpain, putative	0.033	0.0789	0.2111
Brugia malayi	cathepsin L-like cysteine proteinase	0.0106	0.0146	0.0146
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3533	1	1
Leishmania major	centrin, putative,caltractin, putative	0.0138	0.0239	0.0303
Loa Loa (eye worm)	hypothetical protein	0.181	0.5048	0.5033
Trypanosoma brucei	antigen, putative	0.1097	0.2995	0.9347
Leishmania major	hypothetical protein, unknown function	0.033	0.0789	0.2111
Leishmania major	calmodulin-like protein	0.0138	0.0239	0.0303
Loa Loa (eye worm)	hypothetical protein	0.2577	0.7253	0.7245
Leishmania major	calmodulin-like protein	0.0138	0.0239	0.0303
Echinococcus multilocularis	EF hand domain containing family member A2	0.0138	0.0239	0.0239
Trichomonas vaginalis	calpain, putative	0.033	0.0789	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0239	0.0211
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0138	0.0239	0.0094
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1097	0.2995	0.2891
Brugia malayi	calpain family protein 1	0.2907	0.8201	0.8201
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Schistosoma mansoni	rab	0.0138	0.0239	0.0239
Leishmania major	centrin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0106	0.0146	0.0146
Echinococcus granulosus	calpain	0.1097	0.2995	0.2995
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.033	0.0789	0.2111
Brugia malayi	cathepsin L-like precursor	0.0106	0.0146	0.0146
Trypanosoma brucei	calpain, putative	0.033	0.0789	0.2111
Loa Loa (eye worm)	hypothetical protein	0.3533	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1166	0.3194	0.3194
Echinococcus granulosus	calmodulin	0.0138	0.0239	0.0239
Schistosoma mansoni	cathepsin F (C01 family)	0.0106	0.0146	0.0146
Schistosoma mansoni	calpain C (C02 family)	0.1097	0.2995	0.2995
Echinococcus granulosus	calpain 7 C02 family	0.1097	0.2995	0.2995
Echinococcus granulosus	cathepsin l1	0.0106	0.0146	0.0146
Echinococcus multilocularis	calpain A	0.3046	0.8599	0.8599
Loa Loa (eye worm)	EF hand family protein	0.0138	0.0239	0.0211
Trypanosoma cruzi	centrin-3	0.0138	0.0239	0.0094
Echinococcus granulosus	EF hand domain containing family member A2	0.0138	0.0239	0.0239
Echinococcus granulosus	calcium uptake protein 1	0.0139	0.024	0.024
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.1097	0.2995	0.2891
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0138	0.0239	0.0094
Schistosoma mansoni	calmodulin related calcium binding protein	0.0138	0.0239	0.0239
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1166	0.3194	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0106	0.0146	0.0146
Brugia malayi	EF hand family protein	0.0138	0.0239	0.0238
Brugia malayi	Calmodulin-like protein	0.0138	0.0239	0.0238
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0106	0.0146	0.0146
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0106	0.0146	0.0146
Trypanosoma brucei	calmodulin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3533	1	1
Trypanosoma brucei	caltractin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0106	0.0146	0.0146
Onchocerca volvulus		0.0138	0.0239	0.0189
Echinococcus granulosus	cathepsin b	0.3533	1	1
Trypanosoma cruzi	calmodulin, putative	0.0138	0.0239	0.0094
Echinococcus multilocularis	EF hand domain containing family member A2	0.0139	0.024	0.024
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0138	0.0239	0.0303
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0106	0.0146	0.0146
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Brugia malayi	programmed cell death protein 6	0.0138	0.0239	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0069	0.0041
Toxoplasma gondii	EFHC1, putative	0.0138	0.0239	0.0303
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0138	0.0239	0.0239
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0138	0.0239	0.0239
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0138	0.0239	0.0303
Trypanosoma cruzi	centrin, putative	0.0138	0.0239	0.0094
Schistosoma mansoni	calmodulin	0.0138	0.0239	0.0239
Entamoeba histolytica	calpain family cysteine protease, putative	0.033	0.0789	0.3384
Echinococcus multilocularis	calcium uptake protein 1	0.0139	0.024	0.024
Trichomonas vaginalis	calcium binding protein, putative	0.0138	0.0239	0.0303
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Echinococcus granulosus	cathepsin b	0.3533	1	1
Echinococcus multilocularis	neurocalcin	0.0138	0.0239	0.0239
Trypanosoma cruzi	kinesin, putative	0.0767	0.2047	0.1929
Brugia malayi	fibroinase precursor	0.0106	0.0146	0.0146
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0106	0.0146	0.0146
Echinococcus granulosus	cathepsin L	0.0106	0.0146	0.0146
Echinococcus granulosus	cathepsin l1	0.0106	0.0146	0.0146
Toxoplasma gondii	EF hand domain-containing protein	0.0138	0.0239	0.0303
Trichomonas vaginalis	calcium binding proteins, putative	0.0138	0.0239	0.0303
Entamoeba histolytica	calmodulin, putative	0.0138	0.0239	0.0487
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Trypanosoma cruzi	kinesin, putative	0.0767	0.2047	0.1929
Loa Loa (eye worm)	calpain 5	0.0767	0.2047	0.2024
Plasmodium vivax	hypothetical protein, conserved	0.0139	0.024	0.0329
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Brugia malayi	cathepsin F-like cysteine proteinase	0.0106	0.0146	0.0146
Trypanosoma brucei	Calpain-like protein 1.1	0.033	0.0789	0.2111
Echinococcus granulosus	centrin 2	0.0138	0.0239	0.0239
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0106	0.0146	0.0146
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.033	0.0789	0.0653
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3045	0.8598	0.8598
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1166	0.3194	1
Echinococcus multilocularis	cysteine protease	0.0106	0.0146	0.0146
Schistosoma mansoni	centrin-related	0.0138	0.0239	0.0239
Trypanosoma brucei	centrin-3	0.0138	0.0239	0.0303
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0138	0.0239	0.0303
Trypanosoma brucei	I/6 autoantigen	0.0138	0.0239	0.0303
Echinococcus granulosus	cysteine protease	0.0106	0.0146	0.0146
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0106	0.0146	0.0118
Brugia malayi	Papain family cysteine protease containing protein	0.0106	0.0146	0.0146
Leishmania major	calcineurin B subunit, putative	0.0138	0.0239	0.0303
Trypanosoma brucei	Calpain-like protein 1.2	0.033	0.0789	0.2111
Schistosoma mansoni	neuronal calcium sensor	0.0138	0.0239	0.0239
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0106	0.0146	0.0146
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.9347
Leishmania major	calmodulin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	centrin	0.0138	0.0239	0.0239
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.033	0.0789	0.2111
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0138	0.0239	0.0239
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.033	0.0789	0.2111
Schistosoma mansoni	calpain-7 (C02 family)	0.1097	0.2995	0.2995
Trichomonas vaginalis	calcineurin B subunit, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0069	0.0041	0.0041
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Echinococcus granulosus	cathepsin L cysteine protease	0.0106	0.0146	0.0146
Brugia malayi	calpain family protein 1	0.2907	0.8201	0.8201
Trypanosoma brucei	calpain-like protein, putative	0.1097	0.2995	0.9347
Trichomonas vaginalis	calmodulin-2, putative	0.0138	0.0239	0.0303
Entamoeba histolytica	grainin, putative	0.0139	0.024	0.0494
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Brugia malayi	Papain family cysteine protease containing protein	0.0106	0.0146	0.0146
Leishmania major	hypothetical protein, conserved	0.033	0.0789	0.2111
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.9347
Echinococcus granulosus	EF hand domain containing family member A2	0.0139	0.024	0.024
Entamoeba histolytica	protein kinase, putative	0.0767	0.2047	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0106	0.0146	0.0118
Trypanosoma brucei	protein I/6	0.0138	0.0239	0.0303
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0106	0.0146	0.0118
Echinococcus multilocularis	calumenin	0.0139	0.024	0.024
Loa Loa (eye worm)	calpain D	0.033	0.0789	0.0763
Echinococcus multilocularis	calpain 7 (C02 family)	0.1097	0.2995	0.2995
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0106	0.0146	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.033	0.0789	0.2111
Trichomonas vaginalis	hypothetical protein	0.033	0.0789	0.2111
Brugia malayi	calpain 7	0.1097	0.2995	0.2994
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0138	0.0239	0.0303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.033	0.0789	0.0653
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0138	0.0239	0.0239
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1166	0.3194	0.3093
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.033	0.0789	0.2111
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.9347
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Trypanosoma cruzi	centrin, putative	0.0138	0.0239	0.0094
Schistosoma mansoni	reticulocalbin	0.0139	0.024	0.024
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.033	0.0789	0.2111
Schistosoma mansoni	cathepsin B (C01 family)	0.0106	0.0146	0.0146
Trichomonas vaginalis	calcium binding protein, putative	0.0138	0.0239	0.0303
Trypanosoma brucei	Calpain-like protein CALP1.3	0.033	0.0789	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0079	0.0069	0.0069
Brugia malayi	Papain family cysteine protease containing protein	0.0106	0.0146	0.0146
Trichomonas vaginalis	calcium binding protein, putative	0.0138	0.0239	0.0303
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Loa Loa (eye worm)	cysteine protease	0.0106	0.0146	0.0118
Echinococcus multilocularis	cathepsin L	0.0106	0.0146	0.0146
Trichomonas vaginalis	conserved hypothetical protein	0.0138	0.0239	0.0303
Schistosoma mansoni	mitochondrial solute carrier	0.0138	0.0239	0.0239
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3533	1	1
Trypanosoma brucei	Component of motile flagella 41	0.0138	0.0239	0.0303
Trypanosoma brucei	calmodulin, putative	0.0139	0.024	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0106	0.0146	0.0146
Schistosoma mansoni	cathepsin F (C01 family)	0.0106	0.0146	0.0146
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.033	0.0789	0.2111
Brugia malayi	calpain 5	0.0767	0.2047	0.2046
Schistosoma mansoni	reticulocalbin	0.0138	0.0239	0.0239
Trichomonas vaginalis	calpain, putative	0.033	0.0789	0.2111
Trypanosoma brucei	centrin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	hypothetical protein	0.0138	0.0239	0.0239
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Leishmania major	centrin, putative	0.0138	0.0239	0.0303
Trypanosoma cruzi	calmodulin, putative	0.0138	0.0239	0.0094
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.2891
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Loa Loa (eye worm)	calpain family protein 1	0.214	0.5996	0.5984
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.033	0.0789	0.0653
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0106	0.0146	0.0146
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.2891
Echinococcus multilocularis	calpain family protein 1, d	0.214	0.5996	0.5996
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Trichomonas vaginalis	calcium binding protein, putative	0.0138	0.0239	0.0303
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Echinococcus granulosus	calbindin 32	0.0139	0.024	0.024
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0138	0.0239	0.0303
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.2891
Echinococcus multilocularis	calpain 5	0.1097	0.2995	0.2995
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3533	1	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0138	0.0239	0.0325
Schistosoma mansoni	hypothetical protein	0.0138	0.0239	0.0239
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0138	0.0239	0.0487
Leishmania major	phospholipase c-like protein	0.0138	0.0239	0.0303
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Trichomonas vaginalis	myosin light chain 1, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.2907	0.8201	0.8201
Loa Loa (eye worm)	calpain family protein 1	0.2907	0.8201	0.8196
Trypanosoma cruzi	I/6 autoantigen, putative	0.0138	0.0239	0.0094
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Toxoplasma gondii	calmodulin CAM1	0.0139	0.024	0.0308
Toxoplasma gondii	hypothetical protein	0.033	0.0789	0.2111
Echinococcus granulosus	programmed cell death protein	0.0138	0.0239	0.0239
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0065	0.0029	0.0028
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0106	0.0146	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Echinococcus granulosus	cathepsin L	0.0106	0.0146	0.0146
Loa Loa (eye worm)	programmed cell death protein 6	0.0139	0.024	0.0212
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.033	0.0789	0.0653
Schistosoma mansoni	Mername-AA248 (C02 family)	0.1097	0.2995	0.2995
Trypanosoma brucei	calpain-like protein, putative	0.1097	0.2995	0.9347
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0138	0.0239	0.0094
Schistosoma mansoni	neuronal calcium sensor	0.0138	0.0239	0.0239
Echinococcus multilocularis	calmodulin	0.0138	0.0239	0.0239
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1097	0.2995	0.2891
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.033	0.0789	0.0653
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Entamoeba histolytica	calcium binding family protein	0.0138	0.0239	0.0487
Trypanosoma brucei	cysteine peptidase, putative	0.033	0.0789	0.2111
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1097	0.2995	0.9347
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0138	0.0239	0.0239
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.033	0.0789	0.0653
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.033	0.0789	0.0653
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.1097	0.2995	0.9347
Giardia lamblia	Hypothetical protein	0.0139	0.024	0.0308
Leishmania major	i/6 autoantigen-like protein	0.0138	0.0239	0.0303
Leishmania major	kinesin, putative	0.0767	0.2047	0.6236
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0138	0.0239	0.0094
Brugia malayi	Papain family cysteine protease containing protein	0.0106	0.0146	0.0146
Leishmania major	protein kinase, putative	0.0138	0.0239	0.0303
Trichomonas vaginalis	calmodulin, putative	0.0139	0.024	0.0308
Echinococcus granulosus	neuronal calcium sensor	0.0138	0.0239	0.0239
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0106	0.0146	0.0146
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.033	0.0789	0.2111
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1097	0.2995	0.2891
Toxoplasma gondii	centrin	0.0138	0.0239	0.0303
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Trichomonas vaginalis	calmodulin, putative	0.0138	0.0239	0.0303
Schistosoma mansoni	calpain (C02 family)	0.1097	0.2995	0.2995
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.033	0.0789	0.0653
Giardia lamblia	Cathepsin B precursor	0.1166	0.3194	1
Brugia malayi	calpain D	0.033	0.0789	0.0789
Schistosoma mansoni	cathepsin S (C01 family)	0.0106	0.0146	0.0146
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Brugia malayi	Papain family cysteine protease containing protein	0.0106	0.0146	0.0146
Brugia malayi	Cathepsin L-like precursor	0.0106	0.0146	0.0146
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1166	0.3194	1
Echinococcus multilocularis	hypothetical protein	0.1097	0.2995	0.2995
Echinococcus multilocularis	cathepsin L cysteine protease	0.0106	0.0146	0.0146
Trypanosoma cruzi	calmodulin, putative	0.0138	0.0239	0.0094
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.033	0.0789	0.0653
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3533	1	1
Onchocerca volvulus		0.181	0.5048	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0146	0.0118
Schistosoma mansoni	cathepsin C	0.0106	0.0146	0.0146
Leishmania major	hypothetical protein, conserved	0.0139	0.024	0.0308
Trypanosoma cruzi	I/6 autoantigen, putative	0.0138	0.0239	0.0094
Echinococcus multilocularis	neuronal calcium sensor	0.0138	0.0239	0.0239
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0106	0.0146	0.0146
Trypanosoma brucei	calpain-like protein, putative	0.1097	0.2995	0.9347
Echinococcus multilocularis	programmed cell death protein	0.0138	0.0239	0.0239
Brugia malayi	calpain 5	0.033	0.0789	0.0789
Echinococcus multilocularis	cathepsin L cysteine protease	0.0106	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.214	0.5996	0.5984
Entamoeba histolytica	calcium-binding protein, putative	0.0138	0.0239	0.0487
Entamoeba histolytica	hypothetical protein, conserved	0.0139	0.024	0.0494
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.033	0.0789	0.2111
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3045	0.8598	0.8598
Plasmodium vivax	calpain, putative	0.1097	0.2995	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Echinococcus multilocularis	centrin 2	0.0138	0.0239	0.0239
Trypanosoma brucei	kinesin, putative	0.0767	0.2047	0.6236
Plasmodium falciparum	centrin-1	0.0138	0.0239	0.1438
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0138	0.0239	0.0487
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0106	0.0146	0.0146
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.033	0.0789	0.0653
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.3045	0.8598	0.8598
Trichomonas vaginalis	centrin, putative	0.0138	0.0239	0.0303
Entamoeba histolytica	calmodulin, putative	0.0138	0.0239	0.0487
Echinococcus multilocularis	cysteine protease	0.0106	0.0146	0.0146
Brugia malayi	EF hand family protein	0.0139	0.024	0.0239

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 8.57 nM	Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008	ChEMBL.	15317467
Ki (binding)	= 8.57 nM	Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008	ChEMBL.	15317467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 11449064

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 327466