Detailed information for compound 327472

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 421.575 | Formula: C26H35N3O2
  • H donors: 1 H acceptors: 0 LogP: 5.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(CCCCN1CCN(CC1)c1cc(C)c(c(c1)C)OC)c[nH]2
  • InChi: 1S/C26H35N3O2/c1-19-15-22(16-20(2)26(19)31-4)29-13-11-28(12-14-29)10-6-5-7-21-18-27-25-9-8-23(30-3)17-24(21)25/h8-9,15-18,27H,5-7,10-14H2,1-4H3
  • InChiKey: WRIJSTMOEVEIIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0151 0.0899
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0482 0.1317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0221 0.0356 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0181 0.0146
Plasmodium vivax unspecified product 0.0282 0.0482 0.1742
Brugia malayi fibroinase precursor 0.0282 0.0482 0.0482
Trypanosoma cruzi centrin, putative 0.0228 0.0371 0.0338
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0221 0.0356 0.0322
Brugia malayi calpain family protein 1 0.3583 0.7216 0.7216
Onchocerca volvulus 0.005 0.0007 0.0008
Plasmodium vivax vivapain-1 0.053 0.0987 0.3673
Toxoplasma gondii cathepsin CPC2 0.0282 0.0482 0.134
Giardia lamblia Cathepsin L-like protease 0.0282 0.0482 0.1317
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0151 0.0151
Trichomonas vaginalis hypothetical protein 0.0391 0.0703 0.1971
Schistosoma mansoni reticulocalbin 0.0225 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0893 0.1727 0.1727
Echinococcus multilocularis calpain A 0.3808 0.7675 0.7675
Echinococcus granulosus cathepsin L 0.0282 0.0482 0.0482
Onchocerca volvulus 0.0225 0.0365 0.0807
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.7687
Echinococcus multilocularis tumor protein p63 0.0341 0.0601 0.0601
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1725 0.3425 0.3402
Leishmania major programmed cell death 6 protein-like protein 0.0221 0.0356 0.0947
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0225 0.0365 0.0331
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0703 0.1971
Echinococcus granulosus centrin 2 0.0221 0.0356 0.0356
Plasmodium vivax hypothetical protein, conserved 0.0225 0.0365 0.1294
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4947 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0645 0.1222 0.3502
Brugia malayi cathepsin Z-like cysteine proteinase 0.0282 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0282 0.0482 0.0482
Echinococcus multilocularis cathepsin b 0.4947 1 1
Loa Loa (eye worm) hypothetical protein 0.0645 0.1222 0.1222
Brugia malayi gamma-secretase subunit aph-1 0.0258 0.0433 0.0433
Entamoeba histolytica cysteine protease, putative 0.0282 0.0482 0.247
Onchocerca volvulus 0.047 0.0865 0.1924
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1725 0.3425 1
Echinococcus granulosus cysteine protease 0.053 0.0987 0.0987
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0081 0.0072 0.0072
Echinococcus granulosus EF hand domain containing family member A2 0.0221 0.0356 0.0356
Entamoeba histolytica calpain family cysteine protease, putative 0.0391 0.0703 0.3696
Trypanosoma brucei mitochondrial calcium uptake 1 0.0221 0.0356 0.0947
Brugia malayi Papain family cysteine protease containing protein 0.0282 0.0482 0.0482
Brugia malayi Pre-SET motif family protein 0.0413 0.0748 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Leishmania major cathepsin L-like protease 0.0893 0.1727 0.4991
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0181 0.043
Giardia lamblia Alanyl dipeptidyl peptidase 0.0135 0.0181 0.043
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0282 0.0482 0.1742
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0221 0.0356 0.0356
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0148 0.0208 0.051
Trypanosoma brucei centrin, putative 0.0221 0.0356 0.0947
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0181 0.0146
Loa Loa (eye worm) hypothetical protein 0.0282 0.0482 0.0482
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0703 0.0671
Echinococcus multilocularis calmodulin 0.0221 0.0356 0.0356
Trichomonas vaginalis calmodulin, putative 0.0221 0.0356 0.0947
Loa Loa (eye worm) hypothetical protein 0.1287 0.2531 0.2531
Leishmania major proteasome beta 5 subunit, putative 0.0082 0.0072 0.011
Echinococcus multilocularis cathepsin b 0.4947 1 1
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0135 0.0181 0.043
Entamoeba histolytica cysteine proteinase, putative 0.053 0.0987 0.5262
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0282 0.0482 0.1317
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0413 0.0748 0.0748
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0135 0.0181 0.043
Loa Loa (eye worm) calpain D 0.0391 0.0703 0.0703
Brugia malayi Cathepsin L-like precursor 0.0893 0.1727 0.1727
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0893 0.1727 0.4991
Leishmania major calmodulin, putative 0.0221 0.0356 0.0947
Trypanosoma brucei calpain-like protein, putative 0.1341 0.2641 0.7687
Echinococcus granulosus expressed protein 0.0753 0.1441 0.1441
Schistosoma mansoni memapsin-2 (A01 family) 0.0447 0.0818 0.0818
Schistosoma mansoni calmodulin related calcium binding protein 0.0221 0.0356 0.0356
Plasmodium falciparum cysteine proteinase falcipain 1 0.053 0.0987 0.5623
Brugia malayi Papain family cysteine protease containing protein 0.0893 0.1727 0.1727
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0221 0.0356 0.0947
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0282 0.0482 0.247
Giardia lamblia Hypothetical protein 0.0282 0.0482 0.1317
Onchocerca volvulus 0.0221 0.0356 0.0788
Giardia lamblia Cathepsin L precursor 0.0282 0.0482 0.1317
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0282 0.0482 0.1742
Entamoeba histolytica cysteine proteinase, putative 0.0645 0.1222 0.6566
Schistosoma mansoni hypothetical protein 0.0062 0.0032 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.053 0.0987 0.5262
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0082 0.0072 0.0037
Trichomonas vaginalis calcium binding proteins, putative 0.0221 0.0356 0.0947
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0026 0.0026
Onchocerca volvulus 0.0893 0.1727 0.3851
Schistosoma mansoni cathepsin F (C01 family) 0.0893 0.1727 0.1727
Entamoeba histolytica hypothetical protein 0.0282 0.0482 0.247
Toxoplasma gondii hypothetical protein 0.0135 0.0181 0.0455
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0282 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.0482 0.0482
Brugia malayi Cytochrome P450 family protein 0.0053 0.0013 0.0013
Trypanosoma cruzi conserved protein 0.0391 0.0703 0.0671
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0135 0.0181 0.0146
Echinococcus multilocularis centrin 2 0.0221 0.0356 0.0356
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0142 0.0142
Trichomonas vaginalis calmodulin, putative 0.0221 0.0356 0.0947
Echinococcus granulosus proteasome prosome macropain 0.0082 0.0072 0.0072
Trypanosoma cruzi kinesin, putative 0.095 0.1843 0.1815
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0391 0.0703 0.1992
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0386 0.0386
Trypanosoma cruzi cruzipain precursor, putative 0.0988 0.1921 0.1892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Schistosoma mansoni inhibitor of apoptosis protein 0.0081 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0282 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Entamoeba histolytica prolyl oligopeptidase family protein 0.0135 0.0181 0.0806
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0703 0.1971
Giardia lamblia Cathepsin L precursor 0.0282 0.0482 0.1317
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0026 0.0026
Giardia lamblia Cathepsin B precursor 0.0282 0.0482 0.1317
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1725 0.3425 0.3425
Echinococcus multilocularis programmed cell death protein 0.0228 0.0371 0.0371
Schistosoma mansoni cathepsin S (C01 family) 0.0282 0.0482 0.0482
Toxoplasma gondii proteasome subunit beta type, putative 0.0082 0.0072 0.0136
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1287 0.2531 0.2531
Trichomonas vaginalis myosin light chain 1, putative 0.0221 0.0356 0.0947
Plasmodium falciparum serine repeat antigen 2 0.0282 0.0482 0.2639
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Loa Loa (eye worm) hypothetical protein 0.0282 0.0482 0.0482
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0247 0.041 0.041
Trichomonas vaginalis calmodulin, putative 0.0225 0.0365 0.0972
Loa Loa (eye worm) calpain 0.1341 0.2641 0.2641
Giardia lamblia Cathepsin B precursor 0.1725 0.3425 1
Schistosoma mansoni neuronal calcium sensor 0.0221 0.0356 0.0356
Plasmodium falciparum cysteine proteinase falcipain 3 0.0893 0.1727 1
Brugia malayi Papain family cysteine protease containing protein 0.053 0.0987 0.0987
Plasmodium vivax hypothetical protein, conserved 0.0135 0.0181 0.0591
Echinococcus multilocularis programmed cell death protein 0.0228 0.0371 0.0371
Echinococcus granulosus EF hand domain containing family member A2 0.0225 0.0365 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Echinococcus granulosus cathepsin b 0.4947 1 1
Entamoeba histolytica cysteine protease, putative 0.0282 0.0482 0.247
Leishmania major centrin, putative 0.0221 0.0356 0.0947
Brugia malayi Cathepsin L-like precursor 0.0645 0.1222 0.1222
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.2615
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0703 0.1971
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0221 0.0356 0.0356
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0135 0.0181 0.043
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4947 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0151 0.0899
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1725 0.3425 1
Onchocerca volvulus 0.0893 0.1727 0.3851
Brugia malayi hypothetical protein 0.0152 0.0216 0.0216
Plasmodium falciparum proteasome subunit beta type-5 0.0082 0.0072 0.022
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0282 0.0482 0.0482
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0512 0.095 1
Mycobacterium tuberculosis Probable peptidase 0.0512 0.095 0.4018
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0221 0.0356 0.0356
Echinococcus granulosus calumenin 0.0225 0.0365 0.0365
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0135 0.0181 0.043
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0135 0.0181 0.0181
Brugia malayi prolyl oligopeptidase family protein 0.0135 0.0181 0.0181
Loa Loa (eye worm) cathepsin B 0.1725 0.3425 0.3425
Entamoeba histolytica cysteine protease, putative 0.0282 0.0482 0.247
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.2615
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0893 0.1727 0.1727
Trypanosoma cruzi calmodulin, putative 0.0221 0.0356 0.0322
Entamoeba histolytica cysteine proteinase, putative 0.0893 0.1727 0.9358
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.0356 0.0947
Trichomonas vaginalis calcium binding protein, putative 0.0221 0.0356 0.0947
Plasmodium falciparum serine repeat antigen 4 0.0282 0.0482 0.2639
Schistosoma mansoni calpain-7 (C02 family) 0.1341 0.2641 0.2641
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0893 0.1727 0.1727
Entamoeba histolytica calcium-binding protein, putative 0.0221 0.0356 0.1776
Echinococcus multilocularis gamma secretase subunit aph 1 0.0258 0.0433 0.0433
Leishmania major phospholipase c-like protein 0.0221 0.0356 0.0947
Brugia malayi Peptidase C13 family protein 0.0148 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0135 0.0181 0.0181
Plasmodium falciparum serine repeat antigen 7 0.0282 0.0482 0.2639
Echinococcus granulosus caspase 0.0096 0.0101 0.0101
Entamoeba histolytica grainin 2 0.0228 0.0371 0.186
Leishmania major cathepsin L-like protease 0.0988 0.1921 0.5562
Echinococcus multilocularis cathepsin L 0.053 0.0987 0.0987
Echinococcus granulosus calpain A 0.3808 0.7675 0.7675
Plasmodium falciparum plasmepsin IX 0.02 0.0313 0.1641
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0148 0.0208 0.051
Giardia lamblia Cathepsin L precursor 0.0282 0.0482 0.1317
Brugia malayi cathepsin L-like cysteine proteinase 0.0282 0.0482 0.0482
Brugia malayi prolyl oligopeptidase family protein 0.0135 0.0181 0.0181
Trypanosoma cruzi caltractin, putative 0.0221 0.0356 0.0322
Trypanosoma brucei Aph-1 protein, putative 0.0101 0.0111 0.0224
Loa Loa (eye worm) hypothetical protein 0.0645 0.1222 0.1222
Trypanosoma cruzi cysteine peptidase, putative 0.0988 0.1921 0.1892
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0151 0.0151
Brugia malayi Cathepsin L-like precursor 0.0247 0.041 0.041
Brugia malayi Cathepsin L-like precursor 0.0893 0.1727 0.1727
Brugia malayi calpain family protein 1 0.3583 0.7216 0.7216
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3583 0.7216 0.7216
Giardia lamblia Cathepsin L precursor 0.0282 0.0482 0.1317
Leishmania major cathepsin L-like protease 0.0893 0.1727 0.4991
Plasmodium vivax unspecified product 0.0247 0.041 0.1469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0512 0.095 0.2698
Echinococcus multilocularis calpain 7 (C02 family) 0.1341 0.2641 0.2641
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Echinococcus multilocularis acylamino acid releasing enzyme 0.0135 0.0181 0.0181
Loa Loa (eye worm) fibroinase 0.0893 0.1727 0.1727
Brugia malayi Papain family cysteine protease containing protein 0.0282 0.0482 0.0482
Toxoplasma gondii calmodulin CAM1 0.0225 0.0365 0.0995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Trypanosoma brucei calpain-like protein, putative 0.1341 0.2641 0.7687
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.0482 0.1317
Loa Loa (eye worm) hypothetical protein 0.0247 0.041 0.041
Entamoeba histolytica calmodulin, putative 0.0221 0.0356 0.1776
Trypanosoma brucei prolyl endopeptidase 0.1287 0.2531 0.7363
Giardia lamblia Alanyl dipeptidyl peptidase 0.0135 0.0181 0.043
Trypanosoma brucei calpain-like protein, putative 0.1341 0.2641 0.7687
Trichomonas vaginalis calpain, putative 0.0391 0.0703 0.1971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0391 0.0703 0.0671
Giardia lamblia Cysteine protease 0.0282 0.0482 0.1317
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Loa Loa (eye worm) EF hand family protein 0.0221 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0391 0.0703 0.0703
Leishmania major calpain protease-like protein 0.0391 0.0703 0.1971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Trypanosoma brucei Calpain-like protein 1.1 0.0391 0.0703 0.1971
Giardia lamblia Hypothetical protein 0.0225 0.0365 0.0972
Giardia lamblia Cysteine protease 0.0282 0.0482 0.1317
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0081 0.0072 0.0072
Trypanosoma brucei cysteine peptidase C (CPC) 0.1725 0.3425 1
Plasmodium vivax vivapain-2 0.0893 0.1727 0.6505
Echinococcus multilocularis calpain 5 0.1341 0.2641 0.2641
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0135 0.0181 0.0806
Echinococcus granulosus EF HAND 1 calcium binding site 0.0221 0.0356 0.0356
Trypanosoma cruzi Aph-1 protein, putative 0.0101 0.0111 0.0076
Schistosoma mansoni gamma-secretase subunit aph-1 0.0258 0.0433 0.0433
Plasmodium vivax proteasome subunit beta type-1, putative 0.0064 0.0035 0.0034
Trypanosoma brucei prolyl oligopeptidase, putative 0.0512 0.095 0.2698
Loa Loa (eye worm) proteasome subunit beta type 1 0.0064 0.0035 0.0035
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0135 0.0181 0.0396
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0151 0.0151
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0142 0.0142
Onchocerca volvulus 0.0062 0.0032 0.0064
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0221 0.0356 0.0356
Onchocerca volvulus 0.2242 0.448 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3803 0.7667 0.7667
Schistosoma mansoni microtubule-associated protein tau 0.1377 0.2715 0.2715
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0482 0.1317
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0221 0.0356 0.1776
Brugia malayi Cell death protein 3 precursor 0.0088 0.0084 0.0084
Trypanosoma brucei caltractin, putative 0.0228 0.0371 0.0992
Echinococcus multilocularis cysteine protease 0.0893 0.1727 0.1727
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0026 0.0026
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1152 0.2256 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0153 0.0217 0.0217
Brugia malayi cathepsin F-like cysteine proteinase 0.0247 0.041 0.041
Trichomonas vaginalis calmodulin, putative 0.0228 0.0371 0.0992
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.0482 0.1317
Echinococcus granulosus calmodulin 0.0221 0.0356 0.0356
Brugia malayi hypothetical protein 0.0062 0.0032 0.0032
Onchocerca volvulus Cathepsin L homolog 0.0893 0.1727 0.3851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0645 0.1222 0.3502
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0081 0.0072 0.0072
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0282 0.0482 0.247
Brugia malayi Cathepsin L-like precursor 0.0645 0.1222 0.1222
Brugia malayi Papain family cysteine protease containing protein 0.0282 0.0482 0.0482
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1341 0.2641 0.2615
Trypanosoma cruzi cruzipain precursor, putative 0.0247 0.041 0.0377
Trypanosoma cruzi cysteine peptidase, putative 0.0988 0.1921 0.1892
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Schistosoma mansoni calmodulin 0.0221 0.0356 0.0356
Schistosoma mansoni centrin 0.0221 0.0356 0.0356
Schistosoma mansoni calpain C (C02 family) 0.1341 0.2641 0.2641
Entamoeba histolytica cysteine proteinase, putative 0.053 0.0987 0.5262
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0703 0.0671
Entamoeba histolytica prolyl oligopeptidase family protein 0.0135 0.0181 0.0806
Schistosoma mansoni centrin-related 0.0221 0.0356 0.0356
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0282 0.0482 0.1742
Trypanosoma cruzi oligopeptidase b 0.0512 0.095 0.0918
Leishmania major kinesin, putative 0.095 0.1843 0.5333
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.0482 0.0482
Entamoeba histolytica hypothetical protein, conserved 0.0225 0.0365 0.1822
Trypanosoma cruzi Aph-1 protein, putative 0.0101 0.0111 0.0076
Echinococcus granulosus calpain A 0.1341 0.2641 0.2641
Toxoplasma gondii EF hand domain-containing protein 0.0221 0.0356 0.0971
Toxoplasma gondii troponin c, isotype gamma, putative 0.0221 0.0356 0.0971
Leishmania major centrin, putative,caltractin, putative 0.0221 0.0356 0.0947
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Loa Loa (eye worm) ctsf protein 0.0893 0.1727 0.1727
Loa Loa (eye worm) calpain 5 0.095 0.1843 0.1843
Onchocerca volvulus 0.0221 0.0356 0.0788
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.2615
Giardia lamblia Cathepsin B precursor 0.0282 0.0482 0.1317
Trypanosoma cruzi cysteine peptidase, putative 0.0893 0.1727 0.1698
Trypanosoma cruzi cysteine proteinase, putative 0.053 0.0987 0.0955
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0282 0.0482 0.2639
Loa Loa (eye worm) programmed cell death protein 6 0.0225 0.0365 0.0365
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0512 0.095 1
Trypanosoma brucei calmodulin, putative 0.0221 0.0356 0.0947
Trypanosoma cruzi kinesin, putative 0.095 0.1843 0.1815
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.7687
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0022 0.0022
Echinococcus multilocularis proteasome (prosome, macropain) 0.0082 0.0072 0.0072
Trypanosoma cruzi prolyl endopeptidase 0.1287 0.2531 0.2505
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0148 0.0208 0.051
Loa Loa (eye worm) hypothetical protein 0.0088 0.0084 0.0084
Giardia lamblia Hypothetical protein 0.0282 0.0482 0.1317
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0221 0.0356 0.0322
Onchocerca volvulus Legumain homolog 0.0148 0.0208 0.0457
Onchocerca volvulus 0.0081 0.0072 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0703 0.1971
Echinococcus multilocularis neuronal calcium sensor 0.0221 0.0356 0.0356
Entamoeba histolytica protein kinase, putative 0.095 0.1843 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0135 0.0181 0.0806
Schistosoma mansoni calpain (C02 family) 0.1341 0.2641 0.2641
Toxoplasma gondii preprocathepsin c precursor, putative 0.0282 0.0482 0.134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Entamoeba histolytica cysteine protease, putative 0.0282 0.0482 0.247
Leishmania major cathepsin L-like protease 0.0988 0.1921 0.5562
Giardia lamblia Cathepsin B precursor 0.1725 0.3425 1
Onchocerca volvulus 0.0893 0.1727 0.3851
Loa Loa (eye worm) hypothetical protein 0.0282 0.0482 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0282 0.0482 0.1317
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4947 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0282 0.0482 0.1742
Loa Loa (eye worm) hypothetical protein 0.0062 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0135 0.0181 0.0181
Brugia malayi Papain family cysteine protease containing protein 0.053 0.0987 0.0987
Trypanosoma cruzi cysteine peptidase, putative 0.053 0.0987 0.0955
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0282 0.0482 0.1317
Brugia malayi Cathepsin L-like precursor 0.0893 0.1727 0.1727
Entamoeba histolytica cysteine protease, putative 0.0282 0.0482 0.247
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0282 0.0482 0.1317
Toxoplasma gondii EFHC1, putative 0.0221 0.0356 0.0971
Brugia malayi Proteasome A-type and B-type family protein 0.0082 0.0072 0.0072
Plasmodium vivax vivapain-2 0.0893 0.1727 0.6505
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0282 0.0482 0.1742
Trypanosoma cruzi cysteine peptidase, putative 0.0247 0.041 0.0377
Echinococcus granulosus programmed cell death protein 0.0228 0.0371 0.0371
Echinococcus multilocularis EF hand domain containing family member A2 0.0225 0.0365 0.0365
Plasmodium vivax calpain, putative 0.1341 0.2641 1
Schistosoma mansoni neuronal calcium sensor 0.0221 0.0356 0.0356
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0703 0.0671
Trypanosoma cruzi cysteine peptidase, putative 0.0988 0.1921 0.1892
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0512 0.095 0.0918
Schistosoma mansoni cathepsin C 0.0282 0.0482 0.0482
Plasmodium vivax aspartyl protease, putative 0.02 0.0313 0.1096
Leishmania major hypothetical protein, conserved 0.0225 0.0365 0.0972
Plasmodium falciparum serine repeat antigen 9 0.0282 0.0482 0.2639
Entamoeba histolytica calpain large subunit domain III containing protein 0.095 0.1843 1
Giardia lamblia Cysteine protease 0.0282 0.0482 0.1317
Schistosoma mansoni hypothetical protein 0.0221 0.0356 0.0356
Onchocerca volvulus Cathepsin L homolog 0.0282 0.0482 0.1068
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Onchocerca volvulus Cathepsin F homolog 0.0893 0.1727 0.3851
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0148 0.0208 0.051
Brugia malayi EF hand family protein 0.0221 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0059 0.0026 0.0026
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0221 0.0356 0.0947
Plasmodium falciparum peptidase, putative 0.0135 0.0181 0.0861
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0381 0.1415
Plasmodium vivax serine-repeat antigen (SERA) 0.0282 0.0482 0.1742
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0148 0.0208 0.051
Echinococcus multilocularis cathepsin L cysteine protease 0.0893 0.1727 0.1727
Trypanosoma brucei Calpain-like protein 1.2 0.0391 0.0703 0.1971
Echinococcus multilocularis expressed protein 0.0753 0.1441 0.1441
Echinococcus granulosus calbindin 32 0.0225 0.0365 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.053 0.0987 0.2807
Schistosoma mansoni neuronal calcium sensor 0.0221 0.0356 0.0356
Schistosoma mansoni mitochondrial solute carrier 0.0221 0.0356 0.0356
Trypanosoma brucei cysteine peptidase, putative 0.0391 0.0703 0.1971
Loa Loa (eye worm) hypothetical protein 0.3191 0.6418 0.6418
Trypanosoma brucei Calpain-like protein CALP1.3 0.0391 0.0703 0.1971
Entamoeba histolytica cysteine protease, putative 0.0893 0.1727 0.9358
Loa Loa (eye worm) hypothetical protein 0.0081 0.0072 0.0072
Schistosoma mansoni calpain-7 (C02 family) 0.1341 0.2641 0.2641
Loa Loa (eye worm) hypothetical protein 0.2242 0.448 0.448
Loa Loa (eye worm) hypothetical protein 0.4947 1 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.041 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0151 0.0151
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1341 0.2641 0.2615
Leishmania major calcineurin B subunit, putative 0.0221 0.0356 0.0947
Trypanosoma cruzi centrin-3 0.0228 0.0371 0.0338
Echinococcus granulosus tumor protein p63 0.0341 0.0601 0.0601
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0703 0.0671
Entamoeba histolytica calcium binding family protein 0.0221 0.0356 0.1776
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0282 0.0482 0.1742
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Leishmania major calmodulin-like protein 0.0221 0.0356 0.0947
Echinococcus multilocularis microtubule associated protein 2 0.1377 0.2715 0.2715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Giardia lamblia Cathepsin B precursor 0.0282 0.0482 0.1317
Trypanosoma brucei calpain, putative 0.0391 0.0703 0.1971
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0386 0.0386
Onchocerca volvulus 0.0152 0.0216 0.0475
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Echinococcus granulosus calpain 0.1341 0.2641 0.2641
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0135 0.0181 0.0181
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Echinococcus multilocularis calpain 0.1341 0.2641 0.2641
Onchocerca volvulus 0.0059 0.0026 0.0051
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0135 0.0181 0.0146
Loa Loa (eye worm) hypothetical protein 0.0391 0.0703 0.0703
Echinococcus multilocularis caspase 2 0.0088 0.0084 0.0084
Echinococcus granulosus neurocalcin 0.0221 0.0356 0.0356
Loa Loa (eye worm) prolyl oligopeptidase 0.0135 0.0181 0.0181
Trichomonas vaginalis calcium binding protein, putative 0.0221 0.0356 0.0947
Entamoeba histolytica cysteine proteinase 1, putative 0.053 0.0987 0.5262
Trichomonas vaginalis calmodulin-2, putative 0.0221 0.0356 0.0947
Brugia malayi Calmodulin-like protein 0.0221 0.0356 0.0356
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0135 0.0181 0.043
Leishmania major oligopeptidase b 0.0512 0.095 0.2698
Trichomonas vaginalis calmodulin, putative 0.0221 0.0356 0.0947
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.0482 0.0482
Echinococcus granulosus caspase 3 0.007 0.0049 0.0049
Schistosoma mansoni hemoglobinase (C13 family) 0.0148 0.0208 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0893 0.1727 0.4991
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.0482 0.0482
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0282 0.0482 0.2639
Plasmodium vivax aspartyl protease, putative 0.02 0.0313 0.1096
Schistosoma mansoni survival motor neuron protein 0.0048 0.0003 0.0003
Toxoplasma gondii calcium-dependent protein kinase 0.0225 0.0365 0.0995
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0512 0.095 0.4018
Trichomonas vaginalis centrin, putative 0.0221 0.0356 0.0947
Giardia lamblia Cathepsin L precursor 0.0282 0.0482 0.1317
Loa Loa (eye worm) peptidase C13 family protein 0.0148 0.0208 0.0208
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0082 0.0072 0.0072
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.0482 0.1317
Schistosoma mansoni calmodulin 0.0221 0.0356 0.0356
Plasmodium falciparum serine repeat antigen 6 0.0282 0.0482 0.2639
Echinococcus multilocularis inhibitor of apoptosis protein 0.0081 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0114 0.0138 0.0138
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0064 0.0035 0.0026
Schistosoma mansoni reticulocalbin 0.0221 0.0356 0.0356
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.0987 0.0987
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0221 0.0356 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Leishmania major cathepsin L-like protease 0.0893 0.1727 0.4991
Trypanosoma brucei oligopeptidase b 0.0512 0.095 0.2698
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1287 0.2531 0.7363
Trichomonas vaginalis set domain proteins, putative 0.047 0.0864 0.2446
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0135 0.0181 0.0181
Trypanosoma cruzi calmodulin, putative 0.0221 0.0356 0.0322
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0221 0.0356 0.1262
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3803 0.7667 0.7667
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0282 0.0482 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.0482 0.1317
Schistosoma mansoni cathepsin F (C01 family) 0.0893 0.1727 0.1727
Brugia malayi calcium-binding protein 0.0221 0.0356 0.0356
Echinococcus multilocularis EF hand domain containing family member A2 0.0221 0.0356 0.0356
Leishmania major cathepsin L-like protease 0.0893 0.1727 0.4991
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0135 0.0181 0.0806
Brugia malayi prolyl oligopeptidase family protein 0.1287 0.2531 0.2531
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0135 0.0181 0.0181
Trypanosoma brucei protein I/6 0.0221 0.0356 0.0947
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0703 0.1971
Schistosoma mansoni hypothetical protein 0.0221 0.0356 0.0356
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0225 0.0365 0.0365
Entamoeba histolytica cysteine proteinase, putative 0.053 0.0987 0.5262
Plasmodium falciparum centrin-1 0.0221 0.0356 0.1898
Plasmodium vivax proteasome subunit beta type-5, putative 0.0082 0.0072 0.0176
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0081 0.0072 0.0072
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0151 0.0361
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0258 0.0433 0.0433
Plasmodium vivax unspecified product 0.053 0.0987 0.3673
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.053 0.0987 0.0955
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0221 0.0356 0.1776
Schistosoma mansoni hemoglobinase (C13 family) 0.0148 0.0208 0.0208
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0703 0.0671
Trichomonas vaginalis calcium binding protein, putative 0.0221 0.0356 0.0947
Giardia lamblia Cathepsin B precursor 0.1725 0.3425 1
Schistosoma mansoni cathepsin s 0.0247 0.041 0.041
Trypanosoma brucei kinesin, putative 0.095 0.1843 0.5333
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Onchocerca volvulus Cathepsin L homolog 0.0893 0.1727 0.3851
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0148 0.0208 0.051
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0064 0.0035 0.0035
Brugia malayi proteasome subunit beta type 1 0.0064 0.0035 0.0035
Loa Loa (eye worm) calmodulin-like protein 0.0221 0.0356 0.0356
Giardia lamblia Cathepsin L precursor 0.0282 0.0482 0.1317
Leishmania major hypothetical protein, conserved 0.0391 0.0703 0.1971
Entamoeba histolytica cysteine proteinase, putative 0.0893 0.1727 0.9358
Echinococcus multilocularis calumenin 0.0225 0.0365 0.0365
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0512 0.095 0.2698
Plasmodium vivax vivapain-3 0.053 0.0987 0.3673
Plasmodium vivax serine-repeat antigen (SERA) 0.0282 0.0482 0.1742
Onchocerca volvulus 0.0893 0.1727 0.3851
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0003 0.0003
Plasmodium vivax centrin-1, putative 0.0221 0.0356 0.1262
Trypanosoma cruzi calmodulin, putative 0.0221 0.0356 0.0322
Echinococcus granulosus cathepsin l1 0.0893 0.1727 0.1727
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0282 0.0482 0.2639
Loa Loa (eye worm) hypothetical protein 0.0247 0.041 0.041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.0482 0.1317
Leishmania major calpain family cysteine protease-like protein 0.0391 0.0703 0.1971
Loa Loa (eye worm) hypothetical protein 0.0221 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0221 0.0356 0.0322
Giardia lamblia Cathepsin B precursor 0.0282 0.0482 0.1317
Onchocerca volvulus 0.0282 0.0482 0.1068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.0482 0.0482
Entamoeba histolytica cysteine protease, putative 0.0282 0.0482 0.247
Onchocerca volvulus 0.0893 0.1727 0.3851
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0064 0.0035 0.0035
Trichomonas vaginalis calcineurin B subunit, putative 0.0221 0.0356 0.0947
Brugia malayi hypothetical protein 0.0236 0.0386 0.0386
Brugia malayi prolyl oligopeptidase family protein 0.0135 0.0181 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0282 0.0482 0.1317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0282 0.0482 0.0482
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.7687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.053 0.0987 0.2807
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0512 0.095 0.0918
Loa Loa (eye worm) hypothetical protein 0.0081 0.0072 0.0072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0893 0.1727 0.1727
Trypanosoma brucei calpain-like protein, putative 0.1341 0.2641 0.7687
Brugia malayi MH2 domain containing protein 0.0116 0.0142 0.0142
Entamoeba histolytica calmodulin, putative 0.0221 0.0356 0.1776
Brugia malayi cathepsin L-like precursor 0.0645 0.1222 0.1222
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0703 0.0671
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0703 0.0671
Plasmodium falciparum serine repeat antigen 8 0.0282 0.0482 0.2639
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0282 0.0482 0.0482
Leishmania major calmodulin-like protein 0.0221 0.0356 0.0947
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0391 0.0703 0.1971
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0084 0.0084
Echinococcus granulosus Dipeptidyl peptidase 9 0.0135 0.0181 0.0181
Giardia lamblia Encystation-specific protease 0.0282 0.0482 0.1317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Schistosoma mansoni Mername-AA248 (C02 family) 0.1341 0.2641 0.2641
Schistosoma mansoni cathepsin D (A01 family) 0.0226 0.0367 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Onchocerca volvulus 0.0893 0.1727 0.3851
Leishmania major i/6 autoantigen-like protein 0.0221 0.0356 0.0947
Leishmania major cathepsin L-like protease 0.0893 0.1727 0.4991
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0148 0.0208 0.0208
Schistosoma mansoni caspase-3 (C14 family) 0.0096 0.0101 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0153 0.0217 0.0217
Echinococcus granulosus cathepsin L cysteine protease 0.053 0.0987 0.0987
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3803 0.7667 0.7667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0391 0.0703 0.1971
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0082 0.0072 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Trypanosoma brucei calmodulin, putative 0.0225 0.0365 0.0972
Leishmania major calmodulin, putative 0.0221 0.0356 0.0947
Echinococcus multilocularis calmodulin 0.0221 0.0356 0.0356
Trypanosoma cruzi major cysteine proteinase, putative 0.0282 0.0482 0.0448
Giardia lamblia Cathepsin B precursor 0.0282 0.0482 0.1317
Echinococcus granulosus gamma secretase subunit aph 1 0.0258 0.0433 0.0433
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0151 0.0342
Leishmania major centrin, putative 0.0221 0.0356 0.0947
Trichomonas vaginalis calcium binding protein, putative 0.0228 0.0371 0.0992
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0081 0.0072 0.0072
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0893 0.1727 0.1727
Echinococcus multilocularis prolyl endopeptidase 0.1287 0.2531 0.2531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Schistosoma mansoni hypothetical protein 0.0081 0.0072 0.0072
Echinococcus multilocularis neurocalcin 0.0221 0.0356 0.0356
Loa Loa (eye worm) calpain family protein 1 0.3583 0.7216 0.7216
Brugia malayi cathepsin Z-like cysteine proteinase 0.0282 0.0482 0.0482
Trypanosoma cruzi cysteine protease, putative 0.053 0.0987 0.0955
Brugia malayi prolyl oligopeptidase family protein 0.0135 0.0181 0.0181
Echinococcus multilocularis hypothetical protein 0.1341 0.2641 0.2641
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.0703 0.1971
Loa Loa (eye worm) hypothetical protein 0.0152 0.0216 0.0216
Echinococcus multilocularis serotonin receptor 0.0153 0.0217 0.0217
Plasmodium falciparum serine repeat antigen 1 0.0282 0.0482 0.2639
Trypanosoma cruzi cysteine proteinase, putative 0.053 0.0987 0.0955
Trichomonas vaginalis calmodulin, putative 0.0221 0.0356 0.0947
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0282 0.0482 0.1317
Echinococcus granulosus cathepsin b 0.4947 1 1
Echinococcus multilocularis caspase 3 0.007 0.0049 0.0049
Brugia malayi calpain 5 0.0391 0.0703 0.0703
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0135 0.0181 0.0181
Toxoplasma gondii prolyl endopeptidase 0.1287 0.2531 0.737
Entamoeba histolytica grainin, putative 0.0225 0.0365 0.1822
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1341 0.2641 0.7687
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0026 0.0026
Entamoeba histolytica hypothetical protein, conserved 0.0135 0.0181 0.0806
Trichomonas vaginalis calpain, putative 0.0391 0.0703 0.1971
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0282 0.0482 0.0482
Brugia malayi programmed cell death protein 6 0.0221 0.0356 0.0356
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0151 0.0368
Loa Loa (eye worm) prolyl oligopeptidase 0.0135 0.0181 0.0181
Leishmania major hypothetical protein, conserved 0.0221 0.0356 0.0947
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0703 0.1971
Toxoplasma gondii cathepsin CPL 0.0893 0.1727 0.5004
Trypanosoma brucei hypothetical protein, conserved 0.0221 0.0356 0.0947
Giardia lamblia Cathepsin L-like protease 0.0282 0.0482 0.1317
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0082 0.0072 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.0482 0.1317
Echinococcus multilocularis cathepsin L 0.0282 0.0482 0.0482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Trypanosoma brucei antigen, putative 0.1341 0.2641 0.7687
Echinococcus granulosus neuronal calcium sensor 0.0221 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Echinococcus granulosus microtubule associated protein 2 0.1377 0.2715 0.2715
Schistosoma mansoni caspase-7 (C14 family) 0.0096 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.0482 0.1317
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0282 0.0482 0.1742
Loa Loa (eye worm) hypothetical protein 0.0221 0.0356 0.0356
Loa Loa (eye worm) cysteine protease 0.0893 0.1727 0.1727
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0282 0.0482 0.0482
Brugia malayi Cathepsin L-like precursor 0.0893 0.1727 0.1727
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0247 0.041 0.041
Plasmodium falciparum serine repeat antigen 3 0.0282 0.0482 0.2639
Schistosoma mansoni neuronal calcium sensor 0.0221 0.0356 0.0356
Brugia malayi Cathepsin L-like precursor 0.0893 0.1727 0.1727
Schistosoma mansoni cathepsin F (C01 family) 0.0645 0.1222 0.1222
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0064 0.0035 0.0035
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0893 0.1727 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.0987 0.0987
Echinococcus granulosus calpain 7 C02 family 0.1341 0.2641 0.2641
Plasmodium falciparum plasmepsin X 0.02 0.0313 0.1641
Trichomonas vaginalis calmodulin, putative 0.0221 0.0356 0.0947
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0082 0.0072 0.0072
Toxoplasma gondii hypothetical protein 0.0391 0.0703 0.1992
Brugia malayi cathepsin L precursor 0.0282 0.0482 0.0482
Trypanosoma brucei centrin-3 0.0228 0.0371 0.0992
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0282 0.0482 0.1742
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0084 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0893 0.1727 1
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.0356 0.0947
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0096 0.0101 0.0101
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1287 0.2531 0.2531
Schistosoma mansoni ef hand domain family member A2 0.0221 0.0356 0.0356
Trypanosoma brucei calpain, putative 0.0391 0.0703 0.1971
Schistosoma mansoni rab 0.0221 0.0356 0.0356
Schistosoma mansoni cathepsin D (A01 family) 0.0226 0.0367 0.0367
Toxoplasma gondii cathepsin B 0.1725 0.3425 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1341 0.2641 0.2615
Toxoplasma gondii cathepsin CPC1 0.0282 0.0482 0.134
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0282 0.0482 0.1317
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0703 0.0671
Brugia malayi Cathepsin L-like precursor 0.0893 0.1727 0.1727
Toxoplasma gondii centrin, putative 0.0221 0.0356 0.0971
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0135 0.0181 0.0455
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Loa Loa (eye worm) hypothetical protein 0.0282 0.0482 0.0482
Leishmania major cathepsin L-like protease 0.0988 0.1921 0.5562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.0482 0.1317
Echinococcus multilocularis calcium uptake protein 1 0.0225 0.0365 0.0365
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0148 0.0208 0.051
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0096 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.053 0.0987 0.2807
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.074 0.1416 0.1386
Trichomonas vaginalis calcineurin B subunit, putative 0.0225 0.0365 0.0972
Schistosoma mansoni cathepsin B (C01 family) 0.0282 0.0482 0.0482
Trypanosoma cruzi major cysteine proteinase, putative 0.0377 0.0675 0.0642
Onchocerca volvulus 0.0893 0.1727 0.3851
Trichomonas vaginalis calmodulin, putative 0.0221 0.0356 0.0947
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0282 0.0482 0.1317
Trypanosoma brucei centrin, putative 0.0221 0.0356 0.0947
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4947 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Brugia malayi cathepsin F-like cysteine proteinase 0.0282 0.0482 0.0482
Brugia malayi Cathepsin L-like cysteine proteinase 0.0645 0.1222 0.1222
Leishmania major hypothetical protein, unknown function 0.0391 0.0703 0.1971
Echinococcus multilocularis calpain family protein 1, d 0.2633 0.5278 0.5278
Trichomonas vaginalis centrin, putative 0.0221 0.0356 0.0947
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0135 0.0181 0.043
Echinococcus granulosus acylamino acid releasing enzyme 0.0135 0.0181 0.0181
Onchocerca volvulus 0.0645 0.1222 0.2723
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1341 0.2641 0.2615
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0082 0.0072 0.011
Trypanosoma brucei hypothetical protein 0.0391 0.0703 0.1971
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0135 0.0181 0.0455
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0703 0.0671
Loa Loa (eye worm) hypothetical protein 0.0153 0.0217 0.0217
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3803 0.7667 0.7667
Echinococcus granulosus cathepsin l cysteine peptidase 0.0893 0.1727 0.1727
Echinococcus granulosus cathepsin L 0.053 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0645 0.1222 0.1222
Schistosoma mansoni hypothetical protein 0.0048 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Echinococcus multilocularis calbindin 32 0.0225 0.0365 0.0365
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1341 0.2641 0.2615
Trypanosoma cruzi I/6 autoantigen, putative 0.0221 0.0356 0.0322
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0221 0.0356 0.0947
Echinococcus multilocularis caspase 0.0096 0.0101 0.0101
Trichomonas vaginalis calpain, putative 0.0391 0.0703 0.1971
Echinococcus multilocularis serotonin receptor 0.0153 0.0217 0.0217
Echinococcus granulosus calcium uptake protein 1 0.0225 0.0365 0.0365
Trypanosoma cruzi I/6 autoantigen, putative 0.0221 0.0356 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.053 0.0987 0.2807
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0282 0.0482 0.1317
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Brugia malayi calpain 7 0.1341 0.2641 0.2641
Echinococcus multilocularis cysteine protease 0.0893 0.1727 0.1727
Trypanosoma cruzi centrin, putative 0.0228 0.0371 0.0338
Echinococcus granulosus cathepsin L cysteine proteinase 0.0893 0.1727 0.1727
Echinococcus granulosus cathepsin l1 0.0645 0.1222 0.1222
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0082 0.0072 0.0037
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0007 0.0007
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0082 0.0072 0.011
Loa Loa (eye worm) hypothetical protein 0.3583 0.7216 0.7216
Leishmania major cysteine peptidase A (CPA) 0.0893 0.1727 0.4991
Trypanosoma brucei Calpain-like protein 2 0.0391 0.0703 0.1971
Trichomonas vaginalis calmodulin, putative 0.0221 0.0356 0.0947
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0988 0.1921 0.5562
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0282 0.0482 0.1742
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0282 0.0482 0.1317
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1341 0.2641 0.2615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Brugia malayi calpain 5 0.095 0.1843 0.1843
Trypanosoma brucei I/6 autoantigen 0.0221 0.0356 0.0947
Echinococcus multilocularis cathepsin L cysteine protease 0.0893 0.1727 0.1727
Toxoplasma gondii centrin 0.0221 0.0356 0.0971
Giardia lamblia Cysteine protease 0.0282 0.0482 0.1317
Brugia malayi Pre-SET motif family protein 0.0059 0.0026 0.0026
Echinococcus granulosus caspase 2 0.0088 0.0084 0.0084
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0282 0.0482 0.1317
Loa Loa (eye worm) hypothetical protein 0.0236 0.0386 0.0386
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.0671
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.0032 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0151 0.0899
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Entamoeba histolytica cysteine proteinase 2 0.053 0.0987 0.5262
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Plasmodium falciparum serine repeat antigen 5 0.0282 0.0482 0.2639
Leishmania major protein kinase, putative 0.0221 0.0356 0.0947
Echinococcus granulosus prolyl endopeptidase 0.1287 0.2531 0.2531
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971
Schistosoma mansoni calpain-2 (C02 family) 0.0391 0.0703 0.0703
Brugia malayi calpain D 0.0391 0.0703 0.0703
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Onchocerca volvulus Prolyl endopeptidase homolog 0.1287 0.2531 0.5647
Brugia malayi EF hand family protein 0.0225 0.0365 0.0365
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0135 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0893 0.1727 0.4991
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0282 0.0482 0.1317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.0482 0.1317
Loa Loa (eye worm) hypothetical protein 0.0153 0.0217 0.0217
Echinococcus granulosus inhibitor of apoptosis protein 0.0081 0.0072 0.0072
Loa Loa (eye worm) calpain family protein 1 0.2633 0.5278 0.5278
Echinococcus granulosus calpain 5 0.1341 0.2641 0.2641
Plasmodium falciparum calpain 0.0391 0.0703 0.3949
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0026 0.0026
Trypanosoma brucei Component of motile flagella 41 0.0221 0.0356 0.0947
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0221 0.0356 0.0947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0893 0.1727 0.4991
Loa Loa (eye worm) hypothetical protein 0.2633 0.5278 0.5278
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0282 0.0482 0.1742
Toxoplasma gondii aspartyl protease ASP3 0.02 0.0313 0.0843
Entamoeba histolytica cysteine protease, putative 0.053 0.0987 0.5262
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0135 0.0181 0.0181
Trypanosoma cruzi oligopeptidase b 0.0512 0.095 0.0918
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0703 0.1971
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4947 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0282 0.0482 0.0482
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.2615
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1341 0.2641 0.7687
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0026 0.0026
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.0987 0.0987
Onchocerca volvulus Deterin homolog 0.0081 0.0072 0.0152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0703 0.1971

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 60 nM Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells ChEMBL. 15341483
IC50 (binding) = 60 nM Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells ChEMBL. 15341483
IC50 (binding) > 100 nM Displacement of [3H]-spiperone from dopamine D2 receptor of rat striatal membranes ChEMBL. 15341483
IC50 (binding) > 100 nM Displacement of [3H]-spiperone from dopamine D2 receptor of rat striatal membranes ChEMBL. 15341483

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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