Detailed information for compound 327882

Basic information

Technical information
  • TDR Targets ID: 327882
  • Name: 6-[(4-nitrophenyl)methylsulfanyl]-9-(pyridin- 4-ylmethyl)purine
  • MW: 378.408 | Formula: C18H14N6O2S
  • H donors: 0 H acceptors: 6 LogP: 2.75 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)CSc1ncnc2c1ncn2Cc1ccncc1
  • InChi: 1S/C18H14N6O2S/c25-24(26)15-3-1-14(2-4-15)10-27-18-16-17(20-11-21-18)23(12-22-16)9-13-5-7-19-8-6-13/h1-8,11-12H,9-10H2
  • InChiKey: VGTOWFKXWGQGGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[(4-nitrophenyl)methylsulfanyl]-9-(4-pyridylmethyl)purine
  • 6-[(4-nitrophenyl)methylthio]-9-(4-pyridylmethyl)purine
  • 6-[(4-nitrobenzyl)thio]-9-(4-pyridylmethyl)purine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 29 (equilibrative nucleoside transporter), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus equilibrative nucleoside transporter 3 Get druggable targets OG5_127378 All targets in OG5_127378
Brugia malayi Nucleoside transporter family protein Get druggable targets OG5_127378 All targets in OG5_127378
Candida albicans possible nucleoside transporter Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus multilocularis equilibrative nucleoside transporter 3 Get druggable targets OG5_127378 All targets in OG5_127378
Entamoeba histolytica nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus granulosus equilibrative nucleoside transporter Get druggable targets OG5_127378 All targets in OG5_127378
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus multilocularis equilibrative nucleoside transporter protein Get druggable targets OG5_127378 All targets in OG5_127378
Brugia malayi hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog Get druggable targets OG5_127378 All targets in OG5_127378
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Candida albicans possible nucleoside transporter Get druggable targets OG5_127378 All targets in OG5_127378
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Trichomonas vaginalis equilibrative nucleoside transporter, putative Get druggable targets OG5_127378 All targets in OG5_127378
Schistosoma japonicum Equilibrative nucleoside transporter 3, putative Get druggable targets OG5_127378 All targets in OG5_127378
Giardia lamblia Hypothetical protein Get druggable targets OG5_127378 All targets in OG5_127378
Echinococcus multilocularis equilibrative nucleoside transporter 3 Get druggable targets OG5_127378 All targets in OG5_127378
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei purine nucleoside transporter solute carrier family 29 (equilibrative nucleoside transporter), member 1 456 aa 396 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0626 0.1879 1
Plasmodium falciparum serine repeat antigen 9 0.0141 0.0305 0.3028
Echinococcus granulosus EF HAND 1 calcium binding site 0.013 0.0271 0.0271
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0141 0.0305 0.0305
Schistosoma mansoni reticulocalbin 0.0132 0.0277 0.0277
Giardia lamblia Cathepsin B precursor 0.1065 0.3303 1
Entamoeba histolytica cysteine protease, putative 0.0141 0.0305 0.1597
Schistosoma mansoni cathepsin F (C01 family) 0.0353 0.0993 0.0993
Leishmania major centrin, putative 0.013 0.0271 0.0805
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0048 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.0666 0.2001
Echinococcus multilocularis calumenin 0.0132 0.0277 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0305 0.0907
Echinococcus granulosus neuronal calcium sensor 0.013 0.0271 0.0271
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.313 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0141 0.0305 0.3028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.013 0.0271 0.0805
Toxoplasma gondii cathepsin B 0.1065 0.3303 1
Schistosoma mansoni calpain (C02 family) 0.0878 0.2695 0.2695
Loa Loa (eye worm) programmed cell death protein 6 0.0132 0.0277 0.0277
Loa Loa (eye worm) calmodulin-like protein 0.013 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.0141 0.0305 0.1597
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0141 0.0305 0.0907
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0305 0.0305
Onchocerca volvulus 0.0353 0.0993 0.2131
Plasmodium vivax vivapain-2 0.0353 0.0993 0.3672
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0227 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Brugia malayi cathepsin Z-like cysteine proteinase 0.0141 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0384 0.1094 0.1094
Toxoplasma gondii calcium-dependent protein kinase 0.0132 0.0277 0.0821
Giardia lamblia Cathepsin L precursor 0.0141 0.0305 0.0907
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0252 0.0666 0.066
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Schistosoma mansoni neuronal calcium sensor 0.013 0.0271 0.0271
Brugia malayi Nucleoside transporter family protein 0.0098 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0584 0.1753
Plasmodium vivax unspecified product 0.0227 0.0584 0.215
Schistosoma mansoni cathepsin F (C01 family) 0.0353 0.0993 0.0993
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.2691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0305 0.0907
Giardia lamblia Hypothetical protein 0.0098 0.0168 0.0491
Loa Loa (eye worm) hypothetical protein 0.0098 0.0168 0.0168
Trypanosoma brucei protein I/6 0.013 0.0271 0.0805
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Loa Loa (eye worm) hypothetical protein 0.0048 0.0006 0.0006
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0271 0.0805
Trypanosoma cruzi cysteine peptidase, putative 0.0353 0.0993 0.0988
Leishmania major cysteine peptidase A (CPA) 0.0353 0.0993 0.2994
Trypanosoma brucei calpain-like protein, putative 0.0878 0.2695 0.8155
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0305 0.0907
Trypanosoma brucei cysteine peptidase C (CPC) 0.1065 0.3303 1
Echinococcus multilocularis calpain A 0.2487 0.7913 0.7913
Trypanosoma brucei Calpain-like protein 1.1 0.0252 0.0666 0.2001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Trichomonas vaginalis calmodulin, putative 0.013 0.0271 0.0805
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0059 0.0059
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0081 0.0113 0.0113
Loa Loa (eye worm) EF hand family protein 0.013 0.0271 0.0271
Trypanosoma cruzi centrin, putative 0.0138 0.0296 0.029
Toxoplasma gondii cathepsin CPC1 0.0141 0.0305 0.0907
Schistosoma mansoni peroxidasin 0.0065 0.0059 0.0059
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0075 0.0093 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.313 1 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.0168 0.0491
Echinococcus granulosus eukaryotic initiation factor 4A 0.0048 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0267 0.0714 0.2148
Trichomonas vaginalis calpain, putative 0.0252 0.0666 0.2001
Echinococcus granulosus calpain 5 0.0878 0.2695 0.2695
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0252 0.0666 0.2001
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Leishmania major protein kinase, putative 0.013 0.0271 0.0805
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.0168 0.0491
Toxoplasma gondii proteasome subunit beta type, putative 0.0075 0.0093 0.0264
Brugia malayi Cathepsin L-like precursor 0.0353 0.0993 0.0993
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1065 0.3303 1
Trypanosoma brucei calpain, putative 0.0252 0.0666 0.2001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0141 0.0305 0.0305
Echinococcus granulosus calpain A 0.2487 0.7913 0.7913
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0305
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.013 0.0271 0.0266
Entamoeba histolytica calcium binding family protein 0.013 0.0271 0.1418
Onchocerca volvulus Cathepsin L homolog 0.0141 0.0305 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1065 0.3303 1
Echinococcus granulosus calpain 0.0878 0.2695 0.2695
Plasmodium vivax unspecified product 0.0141 0.0305 0.1112
Plasmodium falciparum serine repeat antigen 2 0.0141 0.0305 0.3028
Entamoeba histolytica cysteine protease, putative 0.0353 0.0993 0.5272
Leishmania major hypothetical protein, conserved 0.013 0.0271 0.0805
Leishmania major hypothetical protein, unknown function 0.0252 0.0666 0.2001
Echinococcus granulosus programmed cell death protein 0.0138 0.0296 0.0296
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0141 0.0305 0.1112
Echinococcus granulosus cathepsin b 0.313 1 1
Schistosoma mansoni calpain-2 (C02 family) 0.0252 0.0666 0.0666
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1065 0.3303 0.3299
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0141 0.0305 0.0305
Brugia malayi calpain D 0.0252 0.0666 0.0666
Entamoeba histolytica cysteine protease, putative 0.0141 0.0305 0.1597
Schistosoma mansoni neuronal calcium sensor 0.013 0.0271 0.0271
Trichomonas vaginalis calpain, putative 0.0252 0.0666 0.2001
Leishmania major centrin, putative,caltractin, putative 0.013 0.0271 0.0805
Onchocerca volvulus 0.0267 0.0714 0.1528
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0305
Trypanosoma brucei centrin, putative 0.013 0.0271 0.0805
Loa Loa (eye worm) hypothetical protein 0.313 1 1
Toxoplasma gondii cathepsin CPC2 0.0141 0.0305 0.0907
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Loa Loa (eye worm) hypothetical protein 0.0086 0.0128 0.0128
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2355 0.7486 0.7486
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0132 0.0277 0.0277
Giardia lamblia Cathepsin L precursor 0.0141 0.0305 0.0907
Trypanosoma cruzi cruzipain precursor, putative 0.0353 0.0993 0.0988
Trypanosoma brucei caltractin, putative 0.0138 0.0296 0.0879
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0048 0.0006 0.0006
Schistosoma mansoni centrin-related 0.013 0.0271 0.0271
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0803 0.2454 1
Trichomonas vaginalis calmodulin-2, putative 0.013 0.0271 0.0805
Trypanosoma brucei Calpain-like protein CALP1.3 0.0252 0.0666 0.2001
Plasmodium falciparum centrin-1 0.013 0.0271 0.2689
Onchocerca volvulus 0.0353 0.0993 0.2131
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0252 0.0666 0.2001
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0343 0.0963 0.391
Loa Loa (eye worm) fibroinase 0.0353 0.0993 0.0993
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0059 0.0059
Brugia malayi cathepsin L-like cysteine proteinase 0.0141 0.0305 0.0305
Echinococcus granulosus cathepsin l1 0.0267 0.0714 0.0714
Trichomonas vaginalis centrin, putative 0.013 0.0271 0.0805
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Entamoeba histolytica nucleoside transporter, putative 0.0098 0.0168 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0141 0.0305 0.0907
Trichomonas vaginalis calcium binding protein, putative 0.013 0.0271 0.0805
Giardia lamblia Cathepsin B precursor 0.0141 0.0305 0.0907
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0305 0.0907
Toxoplasma gondii hypothetical protein 0.0252 0.0666 0.2001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Brugia malayi Peroxidasin 0.0065 0.0059 0.0059
Brugia malayi Cathepsin L-like precursor 0.0353 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0098 0.0168 0.0168
Trichomonas vaginalis hypothetical protein 0.0252 0.0666 0.2001
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Giardia lamblia Cathepsin L precursor 0.0141 0.0305 0.0907
Onchocerca volvulus 0.013 0.0271 0.0573
Leishmania major calpain protease-like protein 0.0252 0.0666 0.2001
Onchocerca volvulus Peroxidase homolog 0.0065 0.0059 0.0115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.313 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.2406 0.2406
Loa Loa (eye worm) hypothetical protein 0.013 0.0271 0.0271
Trypanosoma brucei calpain, putative 0.0252 0.0666 0.2001
Entamoeba histolytica cysteine protease, putative 0.0141 0.0305 0.1597
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Echinococcus multilocularis calmodulin 0.013 0.0271 0.0271
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0075 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0086 0.0128 0.0128
Entamoeba histolytica hypothetical protein 0.0141 0.0305 0.1597
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0098 0.0168 0.0168
Trypanosoma brucei prolyl oligopeptidase, putative 0.0153 0.0344 0.1026
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0584 0.0578
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Plasmodium vivax serine-repeat antigen (SERA) 0.0141 0.0305 0.1112
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0075 0.0093 0.0087
Trypanosoma brucei kinesin, putative 0.0626 0.1879 0.568
Schistosoma mansoni peroxidasin 0.0065 0.0059 0.0059
Giardia lamblia Encystation-specific protease 0.0141 0.0305 0.0907
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.013 0.0271 0.0987
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.8155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0252 0.0666 0.066
Trypanosoma brucei Component of motile flagella 41 0.013 0.0271 0.0805
Brugia malayi calcium-binding protein 0.013 0.0271 0.0271
Plasmodium vivax vivapain-1 0.0227 0.0584 0.215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Schistosoma mansoni calpain C (C02 family) 0.0878 0.2695 0.2695
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0141 0.0305 0.1112
Loa Loa (eye worm) cathepsin B 0.1065 0.3303 0.3303
Echinococcus multilocularis prolyl endopeptidase 0.0384 0.1094 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0305 0.0907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Echinococcus granulosus cathepsin L cysteine protease 0.0227 0.0584 0.0584
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0086 0.0128 0.0128
Trichomonas vaginalis calmodulin, putative 0.013 0.0271 0.0805
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Giardia lamblia Cathepsin L precursor 0.0141 0.0305 0.0907
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.2691
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0252 0.0666 0.066
Brugia malayi Papain family cysteine protease containing protein 0.0141 0.0305 0.0305
Echinococcus granulosus equilibrative nucleoside transporter 0.0098 0.0168 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0353 0.0993 1
Echinococcus granulosus prolyl endopeptidase 0.0384 0.1094 0.1094
Trichomonas vaginalis calcium binding protein, putative 0.013 0.0271 0.0805
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0878 0.2695 0.2691
Trypanosoma brucei centrin, putative 0.013 0.0271 0.0805
Echinococcus granulosus cathepsin l cysteine peptidase 0.0353 0.0993 0.0993
Echinococcus multilocularis cysteine protease 0.0353 0.0993 0.0993
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0141 0.0305 0.0305
Trypanosoma brucei Calpain-like protein 2 0.0252 0.0666 0.2001
Entamoeba histolytica cysteine protease, putative 0.0141 0.0305 0.1597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0141 0.0305 0.1112
Leishmania major centrin, putative 0.013 0.0271 0.0805
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0584 0.0584
Echinococcus granulosus sarcoplasmic calcium binding protein 0.013 0.0271 0.0271
Trichomonas vaginalis calmodulin, putative 0.013 0.0271 0.0805
Echinococcus multilocularis calpain 7 (C02 family) 0.0878 0.2695 0.2695
Trypanosoma cruzi calmodulin, putative 0.013 0.0271 0.0266
Echinococcus granulosus cathepsin L 0.0141 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0141 0.0305 0.1112
Entamoeba histolytica calmodulin, putative 0.013 0.0271 0.1418
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0141 0.0305 0.0305
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Onchocerca volvulus Chorion peroxidase homolog 0.0065 0.0059 0.0115
Brugia malayi cathepsin L-like precursor 0.0267 0.0714 0.0714
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0098 0.0168 0.035
Brugia malayi Proteasome A-type and B-type family protein 0.0075 0.0093 0.0093
Loa Loa (eye worm) ctsf protein 0.0353 0.0993 0.0993
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.0666 0.2001
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0141 0.0305 0.3028
Trypanosoma brucei calmodulin, putative 0.0132 0.0277 0.0821
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0048 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0086 0.0128 0.0128
Brugia malayi Cathepsin L-like precursor 0.0353 0.0993 0.0993
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0305 0.0907
Echinococcus granulosus calbindin 32 0.0132 0.0277 0.0277
Entamoeba histolytica grainin, putative 0.0132 0.0277 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.0666 0.2001
Onchocerca volvulus 0.0141 0.0305 0.0645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.0305 0.0907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0305 0.0907
Trichomonas vaginalis calcium binding proteins, putative 0.013 0.0271 0.0805
Echinococcus multilocularis programmed cell death protein 0.0138 0.0296 0.0296
Echinococcus granulosus cathepsin b 0.313 1 1
Trypanosoma brucei centrin-3 0.0138 0.0296 0.0879
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0141 0.0305 0.0907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Loa Loa (eye worm) hypothetical protein 0.0252 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Echinococcus multilocularis proteasome (prosome, macropain) 0.0075 0.0093 0.0093
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0141 0.0305 0.1112
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.013 0.0271 0.0266
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.2691
Leishmania major calmodulin, putative 0.013 0.0271 0.0805
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0252 0.0666 0.066
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0384 0.1094 0.1094
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Onchocerca volvulus 0.013 0.0271 0.0573
Entamoeba histolytica calpain large subunit domain III containing protein 0.0626 0.1879 1
Trypanosoma brucei calmodulin, putative 0.013 0.0271 0.0805
Echinococcus granulosus calumenin 0.0132 0.0277 0.0277
Loa Loa (eye worm) blistered cuticle protein 3 0.0065 0.0059 0.0059
Plasmodium vivax serine-repeat antigen (SERA) 0.0141 0.0305 0.1112
Echinococcus multilocularis hypothetical protein 0.0878 0.2695 0.2695
Onchocerca volvulus 0.0353 0.0993 0.2131
Giardia lamblia Cysteine protease 0.0141 0.0305 0.0907
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0153 0.0344 0.1063
Entamoeba histolytica calcium-binding protein, putative 0.013 0.0271 0.1418
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0584 0.3087
Mycobacterium tuberculosis Probable peptidase 0.0153 0.0344 0.1381
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Trypanosoma cruzi cysteine peptidase, putative 0.0353 0.0993 0.0988
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.8155
Trypanosoma cruzi prolyl endopeptidase 0.0384 0.1094 0.1088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0267 0.0714 0.2148
Brugia malayi calpain family protein 1 0.2355 0.7486 0.7486
Loa Loa (eye worm) hypothetical protein 0.2355 0.7486 0.7486
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0353 0.0993 0.0993
Echinococcus granulosus calcium uptake protein 1 0.0132 0.0277 0.0277
Schistosoma mansoni centrin 0.013 0.0271 0.0271
Brugia malayi hypothetical protein 0.0065 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0305 0.0907
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.0305 0.0907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0059 0.0059
Echinococcus multilocularis calpain 0.0878 0.2695 0.2695
Leishmania major calpain family cysteine protease-like protein 0.0252 0.0666 0.2001
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.013 0.0271 0.0266
Echinococcus multilocularis cathepsin L 0.0141 0.0305 0.0305
Toxoplasma gondii calmodulin CAM1 0.0132 0.0277 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Giardia lamblia Cysteine protease 0.0141 0.0305 0.0907
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0252 0.0666 0.066
Onchocerca volvulus Cathepsin F homolog 0.0353 0.0993 0.2131
Plasmodium vivax proteasome subunit beta type-5, putative 0.0075 0.0093 0.0324
Brugia malayi prolyl oligopeptidase family protein 0.0384 0.1094 0.1094
Trypanosoma brucei mitochondrial calcium uptake 1 0.013 0.0271 0.0805
Entamoeba histolytica hypothetical protein, conserved 0.0132 0.0277 0.1446
Trypanosoma brucei hypothetical protein, conserved 0.013 0.0271 0.0805
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.2485 0.7908 0.7908
Trypanosoma brucei calpain-like protein, putative 0.0878 0.2695 0.8155
Giardia lamblia Cathepsin B precursor 0.0141 0.0305 0.0907
Toxoplasma gondii troponin c, isotype gamma, putative 0.013 0.0271 0.0805
Brugia malayi Cathepsin L-like precursor 0.0353 0.0993 0.0993
Trichomonas vaginalis calcium binding protein, putative 0.0138 0.0296 0.0879
Loa Loa (eye worm) hypothetical protein 0.0267 0.0714 0.0714
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0305 0.0907
Leishmania major hypothetical protein, conserved 0.0132 0.0277 0.0821
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0803 0.2454 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Giardia lamblia Cathepsin B precursor 0.0141 0.0305 0.0907
Schistosoma mansoni ef hand domain family member A2 0.013 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0267 0.0714 0.0714
Giardia lamblia Cathepsin B precursor 0.1065 0.3303 1
Schistosoma mansoni calpain-7 (C02 family) 0.0878 0.2695 0.2695
Brugia malayi Papain family cysteine protease containing protein 0.0353 0.0993 0.0993
Trypanosoma cruzi oligopeptidase b 0.0153 0.0344 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0305 0.0305
Trypanosoma cruzi I/6 autoantigen, putative 0.013 0.0271 0.0266
Loa Loa (eye worm) calpain D 0.0252 0.0666 0.0666
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0059 0.0115
Loa Loa (eye worm) hypothetical protein 0.1477 0.464 0.464
Leishmania major calmodulin-like protein 0.013 0.0271 0.0805
Trypanosoma cruzi centrin, putative 0.0138 0.0296 0.029
Echinococcus granulosus centrin 2 0.013 0.0271 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0305 0.0907
Onchocerca volvulus Cathepsin L homolog 0.0353 0.0993 0.2131
Trypanosoma brucei calpain-like protein, putative 0.0878 0.2695 0.8155
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0252 0.0666 0.066
Echinococcus multilocularis programmed cell death protein 0.0138 0.0296 0.0296
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Trypanosoma cruzi major cysteine proteinase, putative 0.0141 0.0305 0.0299
Schistosoma mansoni cathepsin B (C01 family) 0.0141 0.0305 0.0305
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.013 0.0271 0.0266
Echinococcus multilocularis calcium uptake protein 1 0.0132 0.0277 0.0277
Trypanosoma cruzi cysteine proteinase, putative 0.0227 0.0584 0.0578
Echinococcus granulosus peroxidasin 0.0065 0.0059 0.0059
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0141 0.0305 0.0907
Echinococcus multilocularis cathepsin L cysteine protease 0.0353 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0305
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0141 0.0305 0.0907
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0059 0.0059
Toxoplasma gondii centrin 0.013 0.0271 0.0805
Entamoeba histolytica calpain family cysteine protease, putative 0.0252 0.0666 0.3523
Echinococcus granulosus calpain A 0.0878 0.2695 0.2695
Onchocerca volvulus 0.0353 0.0993 0.2131
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0305
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0575 0.2323
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0141 0.0305 0.0907
Schistosoma mansoni cathepsin F (C01 family) 0.0267 0.0714 0.0714
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.013 0.0271 0.0805
Giardia lamblia Cathepsin B precursor 0.0141 0.0305 0.0907
Echinococcus granulosus cathepsin L 0.0227 0.0584 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.0666 0.2001
Entamoeba histolytica cysteine proteinase, putative 0.0353 0.0993 0.5272
Onchocerca volvulus 0.0353 0.0993 0.2131
Trichomonas vaginalis calcineurin B subunit, putative 0.0132 0.0277 0.0821
Leishmania major i/6 autoantigen-like protein 0.013 0.0271 0.0805
Brugia malayi EF hand family protein 0.013 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0584 0.1753
Brugia malayi cathepsin F-like cysteine proteinase 0.0141 0.0305 0.0305
Schistosoma mansoni cathepsin C 0.0141 0.0305 0.0305
Echinococcus granulosus EF hand domain containing family member A2 0.0132 0.0277 0.0277
Giardia lamblia Cathepsin L precursor 0.0141 0.0305 0.0907
Toxoplasma gondii EFHC1, putative 0.013 0.0271 0.0805
Plasmodium vivax vivapain-2 0.0353 0.0993 0.3672
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Trypanosoma cruzi centrin-3 0.0138 0.0296 0.029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Echinococcus multilocularis centrin 2 0.013 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0353 0.0993 0.2994
Echinococcus multilocularis calmodulin 0.013 0.0271 0.0271
Echinococcus multilocularis cathepsin L cysteine protease 0.0353 0.0993 0.0993
Trichomonas vaginalis calmodulin, putative 0.013 0.0271 0.0805
Echinococcus granulosus proteasome prosome macropain 0.0075 0.0093 0.0093
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0305 0.0305
Echinococcus granulosus calpain 7 C02 family 0.0878 0.2695 0.2695
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Brugia malayi eukaryotic initiation factor 4A 0.0048 0.0006 0.0006
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0141 0.0305 0.1112
Leishmania major proteasome beta 5 subunit, putative 0.0075 0.0093 0.0264
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0227 0.0584 0.0584
Plasmodium falciparum serine repeat antigen 7 0.0141 0.0305 0.3028
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0048 0.0006 0.0006
Loa Loa (eye worm) calpain 0.0878 0.2695 0.2695
Trypanosoma cruzi I/6 autoantigen, putative 0.013 0.0271 0.0266
Leishmania major calmodulin, putative 0.013 0.0271 0.0805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Echinococcus granulosus EF hand domain containing family member A2 0.013 0.0271 0.0271
Trichomonas vaginalis calmodulin, putative 0.013 0.0271 0.0805
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.0168 0.0491
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0252 0.0666 0.2001
Onchocerca volvulus Prolyl endopeptidase homolog 0.0384 0.1094 0.2347
Echinococcus multilocularis cathepsin L 0.0227 0.0584 0.0584
Brugia malayi Blistered cuticle protein 3 0.0065 0.0059 0.0059
Echinococcus multilocularis cathepsin b 0.313 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0141 0.0305 0.0305
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0059 0.0115
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2485 0.7908 0.7908
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0075 0.0093 0.0356
Trichomonas vaginalis calpain, putative 0.0252 0.0666 0.2001
Trypanosoma cruzi cysteine peptidase, putative 0.0353 0.0993 0.0988
Plasmodium falciparum cysteine proteinase falcipain 3 0.0353 0.0993 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.8155
Trypanosoma cruzi calmodulin, putative 0.013 0.0271 0.0266
Entamoeba histolytica calmodulin, putative 0.013 0.0271 0.1418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0353 0.0993 0.0993
Giardia lamblia Hypothetical protein 0.0132 0.0277 0.0821
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.013 0.0271 0.0805
Echinococcus multilocularis calbindin 32 0.0132 0.0277 0.0277
Brugia malayi Cathepsin L-like precursor 0.0353 0.0993 0.0993
Loa Loa (eye worm) calpain family protein 1 0.2355 0.7486 0.7486
Trypanosoma cruzi calmodulin, putative 0.013 0.0271 0.0266
Brugia malayi calpain 5 0.0626 0.1879 0.1879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0353 0.0993 0.0993
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0153 0.0344 0.1381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0305 0.0907
Giardia lamblia Cathepsin L-like protease 0.0141 0.0305 0.0907
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0098 0.0168 0.0491
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.013 0.0271 0.0271
Leishmania major phospholipase c-like protein 0.013 0.0271 0.0805
Trypanosoma brucei calpain-like protein, putative 0.0878 0.2695 0.8155
Trypanosoma cruzi conserved protein 0.0252 0.0666 0.066
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0075 0.0093 0.0264
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0584 0.3087
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Schistosoma mansoni calpain-7 (C02 family) 0.0878 0.2695 0.2695
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Trichomonas vaginalis centrin, putative 0.013 0.0271 0.0805
Schistosoma mansoni calmodulin 0.013 0.0271 0.0271
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Treponema pallidum ATP-dependent RNA helicase 0.0048 0.0006 0.5
Trypanosoma cruzi cysteine proteinase, putative 0.0227 0.0584 0.0578
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0128 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Echinococcus granulosus calmodulin 0.013 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Schistosoma mansoni rab 0.013 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Entamoeba histolytica cysteine proteinase 2 0.0227 0.0584 0.3087
Onchocerca volvulus 0.1477 0.464 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0878 0.2695 0.2691
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0252 0.0666 0.066
Toxoplasma gondii centrin, putative 0.013 0.0271 0.0805
Loa Loa (eye worm) hypothetical protein 0.2103 0.667 0.667
Brugia malayi MH2 domain containing protein 0.0116 0.0226 0.0226
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0584 0.3087
Schistosoma mansoni neuronal calcium sensor 0.013 0.0271 0.0271
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0584 0.3087
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0141 0.0305 0.1112
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0384 0.1094 0.1094
Trichomonas vaginalis calmodulin, putative 0.0132 0.0277 0.0821
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0141 0.0305 0.3028
Brugia malayi calpain 5 0.0252 0.0666 0.0666
Brugia malayi calpain 7 0.0878 0.2695 0.2695
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.013 0.0271 0.1418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0584 0.1753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Plasmodium vivax hypothetical protein, conserved 0.0132 0.0277 0.1007
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.313 1 1
Plasmodium vivax centrin-1, putative 0.013 0.0271 0.0987
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0878 0.2695 0.2691
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0141 0.0305 0.0907
Leishmania major programmed cell death 6 protein-like protein 0.013 0.0271 0.0805
Trichomonas vaginalis calcineurin B subunit, putative 0.013 0.0271 0.0805
Trypanosoma cruzi kinesin, putative 0.0626 0.1879 0.1874
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0048 0.0006 0.0006
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0153 0.0344 0.0338
Schistosoma mansoni cathepsin s 0.0086 0.0128 0.0128
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0059 0.0059
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0141 0.0305 0.0305
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.2485 0.7908 0.7908
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0584 0.0584
Echinococcus multilocularis cysteine protease 0.0353 0.0993 0.0993
Echinococcus multilocularis EF hand domain containing family member A2 0.013 0.0271 0.0271
Echinococcus multilocularis EF HAND 1, calcium binding site 0.013 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0305 0.0907
Trypanosoma brucei cysteine peptidase, putative 0.0252 0.0666 0.2001
Trypanosoma brucei Calpain-like protein 1.2 0.0252 0.0666 0.2001
Entamoeba histolytica grainin 2 0.0138 0.0296 0.1548
Giardia lamblia Cathepsin B precursor 0.1065 0.3303 1
Trypanosoma cruzi oligopeptidase b 0.0153 0.0344 0.0338
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0098 0.0168 0.035
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Schistosoma mansoni neuronal calcium sensor 0.013 0.0271 0.0271
Schistosoma mansoni calmodulin 0.013 0.0271 0.0271
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.013 0.0271 0.0805
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Schistosoma mansoni reticulocalbin 0.013 0.0271 0.0271
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0128 0.0128
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0252 0.0666 0.066
Onchocerca volvulus Dual oxidase homolog 0.0065 0.0059 0.0115
Plasmodium falciparum serine repeat antigen 8 0.0141 0.0305 0.3028
Brugia malayi cathepsin L precursor 0.0141 0.0305 0.0305
Echinococcus granulosus cathepsin L cysteine proteinase 0.0353 0.0993 0.0993
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0141 0.0305 0.1112
Onchocerca volvulus Peroxidase homolog 0.0065 0.0059 0.0115
Echinococcus multilocularis neurocalcin 0.013 0.0271 0.0271
Plasmodium falciparum proteasome subunit beta type-5 0.0075 0.0093 0.0883
Trichomonas vaginalis calmodulin, putative 0.0138 0.0296 0.0879
Loa Loa (eye worm) cysteine protease 0.0353 0.0993 0.0993
Trichomonas vaginalis calmodulin, putative 0.013 0.0271 0.0805
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0226 0.0226
Trichomonas vaginalis calcium binding protein, putative 0.013 0.0271 0.0805
Echinococcus multilocularis peroxidasin 0.0065 0.0059 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Entamoeba histolytica cysteine proteinase, putative 0.0353 0.0993 0.5272
Toxoplasma gondii prolyl endopeptidase 0.0384 0.1094 0.3298
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Plasmodium falciparum serine repeat antigen 1 0.0141 0.0305 0.3028
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0141 0.0305 0.0305
Brugia malayi Calmodulin-like protein 0.013 0.0271 0.0271
Leishmania major calcineurin B subunit, putative 0.013 0.0271 0.0805
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0353 0.0993 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0993 0.2994
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0098 0.0168 0.0168
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0353 0.0993 0.0993
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0878 0.2695 0.8155
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0141 0.0305 0.1112
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0384 0.1094 0.3298
Plasmodium falciparum serine repeat antigen 6 0.0141 0.0305 0.3028
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Toxoplasma gondii EF hand domain-containing protein 0.013 0.0271 0.0805
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0141 0.0305 0.0907
Trichomonas vaginalis myosin light chain 1, putative 0.013 0.0271 0.0805
Brugia malayi programmed cell death protein 6 0.013 0.0271 0.0271
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.013 0.0271 0.0271
Trypanosoma cruzi caltractin, putative 0.013 0.0271 0.0266
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.2691
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0075 0.0093 0.0264
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.0666 0.2001
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0098 0.0168 0.0168
Brugia malayi calpain family protein 1 0.2355 0.7486 0.7486
Brugia malayi Cathepsin L-like cysteine proteinase 0.0267 0.0714 0.0714
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Mycobacterium ulcerans proteasome PrcA 0.0803 0.2454 1
Echinococcus granulosus cysteine protease 0.0227 0.0584 0.0584
Plasmodium falciparum serine repeat antigen 3 0.0141 0.0305 0.3028
Leishmania major hypothetical protein, conserved 0.0252 0.0666 0.2001
Toxoplasma gondii cathepsin CPL 0.0353 0.0993 0.2994
Onchocerca volvulus 0.0132 0.0277 0.0584
Brugia malayi hypothetical protein 0.0098 0.0168 0.0168
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0075 0.0093 0.0466
Loa Loa (eye worm) calpain family protein 1 0.1729 0.5457 0.5457
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0141 0.0305 0.1597
Onchocerca volvulus Cathepsin L homolog 0.0353 0.0993 0.2131
Schistosoma mansoni mitochondrial solute carrier 0.013 0.0271 0.0271
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0141 0.0305 0.1597
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0878 0.2695 0.8155
Echinococcus multilocularis calpain family protein 1, d 0.1729 0.5457 0.5457
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0878 0.2695 0.2691
Trypanosoma cruzi cysteine protease, putative 0.0227 0.0584 0.0578
Onchocerca volvulus 0.0065 0.0059 0.0115
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.0666 0.2001
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0878 0.2695 0.2691
Brugia malayi fibroinase precursor 0.0141 0.0305 0.0305
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.313 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0252 0.0666 0.066
Entamoeba histolytica cysteine proteinase 1, putative 0.0227 0.0584 0.3087
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0252 0.0666 0.066
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0227 0.0584 0.0578
Leishmania major kinesin, putative 0.0626 0.1879 0.568
Schistosoma mansoni cathepsin S (C01 family) 0.0141 0.0305 0.0305
Trichomonas vaginalis calmodulin, putative 0.013 0.0271 0.0805
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0132 0.0277 0.0271
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.066
Giardia lamblia Cathepsin L-like protease 0.0141 0.0305 0.0907
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0153 0.0344 0.1026
Onchocerca volvulus 0.0065 0.0059 0.0115
Leishmania major calmodulin-like protein 0.013 0.0271 0.0805
Trypanosoma cruzi kinesin, putative 0.0626 0.1879 0.1874
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0075 0.0093 0.0093
Giardia lamblia Hypothetical protein 0.0141 0.0305 0.0907
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0305
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0252 0.0666 0.2001
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0252 0.0666 0.2001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0227 0.0584 0.0584
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0128 0.0123
Schistosoma mansoni hypothetical protein 0.0252 0.0666 0.0666
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0878 0.2695 0.2691
Echinococcus granulosus cathepsin l1 0.0353 0.0993 0.0993
Trypanosoma brucei I/6 autoantigen 0.013 0.0271 0.0805
Brugia malayi Cathepsin L-like precursor 0.0353 0.0993 0.0993
Echinococcus multilocularis EF hand domain containing family member A2 0.0132 0.0277 0.0277
Trypanosoma cruzi major cysteine proteinase, putative 0.0141 0.0305 0.0299
Echinococcus granulosus neurocalcin 0.013 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0353 0.0993 0.2994
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0141 0.0305 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0993 0.2994
Trypanosoma brucei oligopeptidase b 0.0153 0.0344 0.1026
Brugia malayi Cathepsin L-like precursor 0.0267 0.0714 0.0714
Plasmodium vivax vivapain-3 0.0227 0.0584 0.215
Plasmodium falciparum serine repeat antigen 5 0.0141 0.0305 0.3028
Loa Loa (eye worm) calpain 5 0.0626 0.1879 0.1879
Schistosoma mansoni calmodulin related calcium binding protein 0.013 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Schistosoma mansoni hypothetical protein 0.013 0.0271 0.0271
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Leishmania major oligopeptidase b 0.0153 0.0344 0.1026
Brugia malayi EF hand family protein 0.0132 0.0277 0.0277
Plasmodium falciparum serine repeat antigen 4 0.0141 0.0305 0.3028
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.0666 0.2001
Entamoeba histolytica cysteine protease, putative 0.0227 0.0584 0.3087
Onchocerca volvulus 0.0353 0.0993 0.2131
Giardia lamblia Hypothetical protein 0.0141 0.0305 0.0907
Brugia malayi Papain family cysteine protease containing protein 0.0141 0.0305 0.0305
Giardia lamblia Cathepsin B precursor 0.0141 0.0305 0.0907
Giardia lamblia Cathepsin L precursor 0.0141 0.0305 0.0907
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Schistosoma mansoni Mername-AA248 (C02 family) 0.0878 0.2695 0.2695
Schistosoma mansoni hypothetical protein 0.013 0.0271 0.0271
Brugia malayi Papain family cysteine protease containing protein 0.0141 0.0305 0.0305
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0098 0.0168 0.0168
Trypanosoma brucei antigen, putative 0.0878 0.2695 0.8155
Loa Loa (eye worm) hypothetical protein 0.0267 0.0714 0.0714
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Brugia malayi cathepsin F-like cysteine proteinase 0.0086 0.0128 0.0128
Entamoeba histolytica cysteine protease, putative 0.0141 0.0305 0.1597
Echinococcus multilocularis calpain 5 0.0878 0.2695 0.2695
Loa Loa (eye worm) hypothetical protein 0.0353 0.0993 0.0993
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0584 0.1753
Loa Loa (eye worm) hypothetical protein 0.1729 0.5457 0.5457
Entamoeba histolytica cysteine proteinase, putative 0.0267 0.0714 0.3782
Giardia lamblia Cysteine protease 0.0141 0.0305 0.0907
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0267 0.0714 0.0709
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2485 0.7908 0.7908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0353 0.0993 0.2994
Trypanosoma brucei hypothetical protein 0.0252 0.0666 0.2001
Echinococcus multilocularis neuronal calcium sensor 0.013 0.0271 0.0271
Onchocerca volvulus 0.0353 0.0993 0.2131
Loa Loa (eye worm) hypothetical protein 0.0065 0.0059 0.0059
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0075 0.0093 0.0264
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0153 0.0344 0.1063
Trypanosoma brucei prolyl endopeptidase 0.0384 0.1094 0.3298
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0305 0.0305
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0153 0.0344 0.1026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0305 0.0305
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0226 0.0226
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0059 0.0059
Onchocerca volvulus 0.0065 0.0059 0.0115
Plasmodium falciparum calpain 0.0252 0.0666 0.6682
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0271 0.0805
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.013 0.0271 0.1418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.0305 0.0907
Trypanosoma cruzi cysteine peptidase, putative 0.0353 0.0993 0.0988
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0153 0.0344 0.0338
Plasmodium falciparum cysteine proteinase falcipain 1 0.0227 0.0584 0.5855
Toxoplasma gondii preprocathepsin c precursor, putative 0.0141 0.0305 0.0907
Plasmodium vivax calpain, putative 0.0878 0.2695 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1065 0.3303 0.3303
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.013 0.0271 0.0266
Leishmania major cathepsin L-like protease 0.0353 0.0993 0.2994
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0305
Plasmodium vivax unspecified product 0.0086 0.0128 0.0455
Echinococcus multilocularis cathepsin b 0.313 1 1
Giardia lamblia Cysteine protease 0.0141 0.0305 0.0907
Loa Loa (eye worm) hypothetical protein 0.0086 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.013 0.0271 0.0271
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0141 0.0305 0.1112
Brugia malayi Cathepsin L-like precursor 0.0267 0.0714 0.0714

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2165 nM Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane ChEMBL. 15481982
Ki (binding) = 2165 nM Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane ChEMBL. 15481982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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