Detailed information for compound 328343

Basic information

Technical information
  • TDR Targets ID: 328343
  • Name: 1-[3-(4-chlorophenyl)-1-[4-[4-(2-methoxypheny l)piperazin-1-yl]butyl]-6,7-dihydro-4H-pyrazo lo[4,3-c]pyridin-5-yl]ethanone
  • MW: 522.081 | Formula: C29H36ClN5O2
  • H donors: 0 H acceptors: 2 LogP: 4.14 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1N1CCN(CC1)CCCCn1nc(c2c1CCN(C2)C(=O)C)c1ccc(cc1)Cl
  • InChi: 1S/C29H36ClN5O2/c1-22(36)34-16-13-26-25(21-34)29(23-9-11-24(30)12-10-23)31-35(26)15-6-5-14-32-17-19-33(20-18-32)27-7-3-4-8-28(27)37-2/h3-4,7-12H,5-6,13-21H2,1-2H3
  • InChiKey: AOMPLZSTGKLXGE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[3-(4-chlorophenyl)-1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone
  • 1-[3-(4-chlorophenyl)-1-[4-[4-(2-methoxyphenyl)piperazino]butyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone
  • 1-[3-(4-chlorophenyl)-1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-6,7-dihydro-4H-pyrazolo[4,5-c]pyridin-5-yl]ethanone
  • 1-[3-(4-chlorophenyl)-1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-6,7-dihydro-4H-pyrazolo[4,5-c]pyridin-5-yl]ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi EF hand family protein 0.0146 0.0085 0.0085
Loa Loa (eye worm) cysteine protease 0.0127 0.0028 0.0028
Echinococcus multilocularis calumenin 0.0146 0.0087 0.0059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3345 1 1
Echinococcus granulosus centrin 2 0.0146 0.0085 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1107 0.3065 0.3065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Leishmania major calmodulin-like protein 0.0146 0.0085 0.0188
Leishmania major hypothetical protein, conserved 0.0146 0.0085 0.0188
Onchocerca volvulus 0.0127 0.0028 0.0052
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0127 0.0028 0.0028
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3345 1 1
Trichomonas vaginalis centrin, putative 0.0146 0.0085 0.0277
Echinococcus granulosus neurocalcin 0.0146 0.0085 0.0085
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0146 0.0085 0.0189
Schistosoma mansoni calpain C (C02 family) 0.1104 0.3055 0.3055
Trichomonas vaginalis calmodulin, putative 0.0151 0.0103 0.0336
Echinococcus granulosus calumenin 0.0146 0.0087 0.0087
Echinococcus granulosus calcium uptake protein 1 0.0146 0.0087 0.0087
Brugia malayi Cathepsin L-like precursor 0.0127 0.0028 0.0028
Giardia lamblia Cathepsin B precursor 0.1107 0.3065 1
Schistosoma mansoni hypothetical protein 0.0146 0.0085 0.0085
Trypanosoma brucei antigen, putative 0.1104 0.3055 0.9966
Loa Loa (eye worm) hypothetical protein 0.0127 0.0028 0.0028
Echinococcus multilocularis calpain A 0.3073 0.9156 0.9154
Echinococcus granulosus calpain 5 0.1104 0.3055 0.3055
Toxoplasma gondii troponin c, isotype gamma, putative 0.0146 0.0085 0.0188
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0146 0.0085 0.0085
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.9966
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Onchocerca volvulus 0.0127 0.0028 0.0052
Trypanosoma brucei calpain, putative 0.0332 0.0662 0.2089
Schistosoma mansoni calpain-2 (C02 family) 0.0332 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.3345 1 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0332 0.0662 0.216
Leishmania major i/6 autoantigen-like protein 0.0146 0.0085 0.0188
Toxoplasma gondii EF hand domain-containing protein 0.0146 0.0085 0.0188
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.3055
Loa Loa (eye worm) calpain family protein 1 0.2926 0.8703 0.8703
Entamoeba histolytica calmodulin, putative 0.0146 0.0085 0.0418
Loa Loa (eye worm) hypothetical protein 0.2595 0.7674 0.7674
Onchocerca volvulus Cathepsin L homolog 0.0127 0.0028 0.0052
Toxoplasma gondii centrin 0.0146 0.0085 0.0188
Onchocerca volvulus 0.1822 0.5282 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.9966
Schistosoma mansoni centrin-related 0.0146 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0127 0.0028 0.0028
Brugia malayi Calmodulin-like protein 0.0146 0.0085 0.0085
Giardia lamblia Cathepsin B precursor 0.1107 0.3065 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Leishmania major phospholipase c-like protein 0.0146 0.0085 0.0188
Brugia malayi calcium-binding protein 0.0146 0.0085 0.0085
Plasmodium vivax centrin-1, putative 0.0146 0.0085 0.0189
Loa Loa (eye worm) programmed cell death protein 6 0.0146 0.0087 0.0087
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0332 0.0662 0.0662
Trypanosoma cruzi conserved protein 0.0332 0.0662 0.0662
Entamoeba histolytica grainin, putative 0.0146 0.0087 0.0429
Echinococcus granulosus cathepsin l1 0.0127 0.0028 0.0028
Schistosoma mansoni neuronal calcium sensor 0.0146 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3072 0.9154 0.9152
Leishmania major protein kinase, putative 0.0146 0.0085 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Echinococcus multilocularis calmodulin 0.0146 0.0085 0.0057
Trichomonas vaginalis calcineurin B subunit, putative 0.0146 0.0087 0.0284
Trichomonas vaginalis calcineurin B subunit, putative 0.0146 0.0085 0.0277
Trypanosoma brucei kinesin, putative 0.0772 0.2026 0.658
Trypanosoma cruzi kinesin, putative 0.0772 0.2026 0.2026
Onchocerca volvulus Cathepsin F homolog 0.0127 0.0028 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.0028 0.0028
Leishmania major calmodulin, putative 0.0146 0.0085 0.0188
Leishmania major centrin, putative 0.0146 0.0085 0.0188
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0146 0.0085 0.0418
Leishmania major calmodulin-like protein 0.0146 0.0085 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0332 0.0662 0.216
Toxoplasma gondii EFHC1, putative 0.0146 0.0085 0.0188
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Echinococcus granulosus cathepsin b 0.3345 1 1
Trichomonas vaginalis calcium binding protein, putative 0.0146 0.0085 0.0277
Loa Loa (eye worm) calpain 5 0.0772 0.2026 0.2026
Leishmania major hypothetical protein, conserved 0.0146 0.0087 0.0195
Echinococcus granulosus calmodulin 0.0146 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0146 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0085 0.0277
Onchocerca volvulus 0.0146 0.0085 0.016
Trypanosoma cruzi calmodulin, putative 0.0146 0.0085 0.0085
Trypanosoma brucei centrin, putative 0.0146 0.0085 0.0188
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0332 0.0662 0.2089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0085 0.0277
Toxoplasma gondii cathepsin B 0.1107 0.3065 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1104 0.3055 0.3055
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.3055
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Leishmania major calcineurin B subunit, putative 0.0146 0.0085 0.0188
Echinococcus multilocularis EF hand domain containing family member A2 0.0146 0.0085 0.0057
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3345 1 1
Schistosoma mansoni mitochondrial solute carrier 0.0146 0.0085 0.0085
Leishmania major calpain protease-like protein 0.0332 0.0662 0.2089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Trichomonas vaginalis calcium binding protein, putative 0.0146 0.0085 0.0277
Trypanosoma cruzi centrin, putative 0.0151 0.0103 0.0103
Onchocerca volvulus 0.0127 0.0028 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Trypanosoma brucei cysteine peptidase C (CPC) 0.1107 0.3065 1
Schistosoma mansoni calpain (C02 family) 0.1104 0.3055 0.3055
Trypanosoma brucei centrin, putative 0.0146 0.0085 0.0188
Leishmania major centrin, putative,caltractin, putative 0.0146 0.0085 0.0188
Entamoeba histolytica calcium binding family protein 0.0146 0.0085 0.0418
Loa Loa (eye worm) hypothetical protein 0.0332 0.0662 0.0662
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0332 0.0662 0.0662
Schistosoma mansoni neuronal calcium sensor 0.0146 0.0085 0.0085
Trichomonas vaginalis hypothetical protein 0.0332 0.0662 0.216
Trypanosoma cruzi centrin-3 0.0151 0.0103 0.0103
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0146 0.0085 0.0085
Leishmania major calmodulin, putative 0.0146 0.0085 0.0188
Echinococcus granulosus cathepsin l cysteine peptidase 0.0127 0.0028 0.0028
Leishmania major calpain family cysteine protease-like protein 0.0332 0.0662 0.2089
Schistosoma mansoni reticulocalbin 0.0146 0.0087 0.0087
Onchocerca volvulus 0.0127 0.0028 0.0052
Onchocerca volvulus 0.0127 0.0028 0.0052
Trypanosoma brucei calpain, putative 0.0332 0.0662 0.2089
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0332 0.0662 0.2089
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Brugia malayi EF hand family protein 0.0146 0.0087 0.0087
Loa Loa (eye worm) calmodulin-like protein 0.0146 0.0085 0.0085
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0146 0.0085 0.0418
Leishmania major hypothetical protein, unknown function 0.0332 0.0662 0.2089
Schistosoma mansoni neuronal calcium sensor 0.0146 0.0085 0.0085
Trichomonas vaginalis calpain, putative 0.0332 0.0662 0.216
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0332 0.0662 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3345 1 1
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0146 0.0085 0.0188
Trypanosoma brucei Calpain-like protein 1.1 0.0332 0.0662 0.2089
Schistosoma mansoni calmodulin 0.0146 0.0085 0.0085
Echinococcus multilocularis neuronal calcium sensor 0.0146 0.0085 0.0057
Echinococcus granulosus calpain A 0.3073 0.9156 0.9156
Plasmodium falciparum centrin-1 0.0146 0.0085 0.0901
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0332 0.0662 0.216
Brugia malayi calpain 7 0.1104 0.3055 0.3055
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Echinococcus granulosus programmed cell death protein 0.0151 0.0103 0.0103
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1104 0.3055 0.9966
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0146 0.0087 0.0087
Loa Loa (eye worm) cathepsin B 0.1107 0.3065 0.3065
Echinococcus multilocularis calpain 5 0.1104 0.3055 0.3035
Toxoplasma gondii calmodulin CAM1 0.0146 0.0087 0.0195
Trichomonas vaginalis calmodulin, putative 0.0146 0.0085 0.0277
Echinococcus granulosus calpain 7 C02 family 0.1104 0.3055 0.3055
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0146 0.0085 0.0188
Trypanosoma cruzi I/6 autoantigen, putative 0.0146 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1107 0.3065 0.3065
Trypanosoma brucei cysteine peptidase, putative 0.0332 0.0662 0.2089
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0146 0.0085 0.0085
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Brugia malayi Papain family cysteine protease containing protein 0.0127 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.2926 0.8703 0.8703
Schistosoma mansoni hypothetical protein 0.0332 0.0662 0.0662
Leishmania major kinesin, putative 0.0772 0.2026 0.658
Trypanosoma brucei centrin-3 0.0151 0.0103 0.0248
Plasmodium falciparum calpain 0.0332 0.0662 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1104 0.3055 0.3055
Schistosoma mansoni ef hand domain family member A2 0.0146 0.0085 0.0085
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0332 0.0662 0.0662
Trypanosoma cruzi I/6 autoantigen, putative 0.0146 0.0085 0.0085
Trichomonas vaginalis calpain, putative 0.0332 0.0662 0.216
Echinococcus granulosus calpain 0.1104 0.3055 0.3055
Echinococcus multilocularis calmodulin 0.0146 0.0085 0.0057
Echinococcus multilocularis EF hand domain containing family member A2 0.0146 0.0087 0.0059
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3072 0.9154 0.9154
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0146 0.0085 0.0277
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0332 0.0662 0.0662
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3345 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0332 0.0662 0.216
Leishmania major programmed cell death 6 protein-like protein 0.0146 0.0085 0.0188
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.3055
Brugia malayi Cathepsin L-like precursor 0.0127 0.0028 0.0028
Entamoeba histolytica protein kinase, putative 0.0772 0.2026 1
Schistosoma mansoni calmodulin related calcium binding protein 0.0146 0.0085 0.0085
Entamoeba histolytica grainin 2 0.0151 0.0103 0.0508
Loa Loa (eye worm) ctsf protein 0.0127 0.0028 0.0028
Echinococcus granulosus EF HAND 1 calcium binding site 0.0146 0.0085 0.0085
Echinococcus granulosus neuronal calcium sensor 0.0146 0.0085 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0028 0.0136
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Echinococcus multilocularis neurocalcin 0.0146 0.0085 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Trypanosoma brucei Calpain-like protein CALP1.3 0.0332 0.0662 0.2089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.9966
Echinococcus multilocularis programmed cell death protein 0.0151 0.0103 0.0076
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0146 0.0085 0.0057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0332 0.0662 0.0662
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0146 0.0085 0.0057
Loa Loa (eye worm) calpain 0.1104 0.3055 0.3055
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Trypanosoma brucei calmodulin, putative 0.0146 0.0085 0.0188
Trichomonas vaginalis calmodulin, putative 0.0146 0.0085 0.0277
Plasmodium vivax calpain, putative 0.1104 0.3055 1
Loa Loa (eye worm) calpain D 0.0332 0.0662 0.0662
Brugia malayi Cathepsin L-like precursor 0.0127 0.0028 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0028 0.0028
Trichomonas vaginalis calmodulin, putative 0.0146 0.0087 0.0284
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1104 0.3055 0.3055
Schistosoma mansoni calpain-7 (C02 family) 0.1104 0.3055 0.3055
Echinococcus granulosus calbindin 32 0.0146 0.0087 0.0087
Echinococcus granulosus cathepsin L cysteine proteinase 0.0127 0.0028 0.0028
Brugia malayi calpain family protein 1 0.2926 0.8703 0.8703
Brugia malayi calpain family protein 1 0.2926 0.8703 0.8703
Trypanosoma cruzi calmodulin, putative 0.0146 0.0085 0.0085
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Schistosoma mansoni reticulocalbin 0.0146 0.0085 0.0085
Entamoeba histolytica hypothetical protein, conserved 0.0146 0.0087 0.0429
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0332 0.0662 0.216
Trichomonas vaginalis myosin light chain 1, putative 0.0146 0.0085 0.0277
Trichomonas vaginalis calmodulin, putative 0.0146 0.0085 0.0277
Brugia malayi Cathepsin L-like precursor 0.0127 0.0028 0.0028
Loa Loa (eye worm) EF hand family protein 0.0146 0.0085 0.0085
Trichomonas vaginalis calmodulin, putative 0.0146 0.0085 0.0277
Brugia malayi calpain 5 0.0772 0.2026 0.2026
Trichomonas vaginalis calmodulin, putative 0.0146 0.0085 0.0277
Trichomonas vaginalis calmodulin, putative 0.0146 0.0085 0.0277
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3072 0.9154 0.9154
Echinococcus multilocularis calbindin 32 0.0146 0.0087 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0028 0.0136
Echinococcus multilocularis calpain family protein 1, d 0.2154 0.631 0.63
Trichomonas vaginalis calmodulin-2, putative 0.0146 0.0085 0.0277
Trichomonas vaginalis calcium binding protein, putative 0.0151 0.0103 0.0336
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1104 0.3055 0.3055
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3072 0.9154 0.9154
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0332 0.0662 0.216
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0332 0.0662 0.2089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma brucei calpain-like protein, putative 0.1104 0.3055 0.9966
Trichomonas vaginalis centrin, putative 0.0146 0.0085 0.0277
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Echinococcus multilocularis centrin 2 0.0146 0.0085 0.0057
Echinococcus granulosus cathepsin b 0.3345 1 1
Loa Loa (eye worm) hypothetical protein 0.1822 0.5282 0.5282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma cruzi centrin, putative 0.0151 0.0103 0.0103
Trypanosoma brucei protein I/6 0.0146 0.0085 0.0188
Entamoeba histolytica cysteine protease, putative 0.0127 0.0028 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Giardia lamblia Cathepsin B precursor 0.1107 0.3065 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.9966
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0332 0.0662 0.0662
Echinococcus granulosus EF hand domain containing family member A2 0.0146 0.0085 0.0085
Trypanosoma brucei calpain-like protein, putative 0.1104 0.3055 0.9966
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0146 0.0085 0.0085
Trypanosoma brucei Calpain-like protein 1.2 0.0332 0.0662 0.2089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1107 0.3065 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0332 0.0662 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma brucei hypothetical protein 0.0332 0.0662 0.2089
Schistosoma mansoni hypothetical protein 0.0146 0.0085 0.0085
Echinococcus multilocularis programmed cell death protein 0.0151 0.0103 0.0076
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1107 0.3065 1
Toxoplasma gondii hypothetical protein 0.0332 0.0662 0.2089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Echinococcus multilocularis calpain 7 (C02 family) 0.1104 0.3055 0.3035
Schistosoma mansoni Mername-AA248 (C02 family) 0.1104 0.3055 0.3055
Onchocerca volvulus Cathepsin L homolog 0.0127 0.0028 0.0052
Brugia malayi calpain 5 0.0332 0.0662 0.0662
Trichomonas vaginalis calpain, putative 0.0332 0.0662 0.216
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1104 0.3055 0.3055
Schistosoma mansoni centrin 0.0146 0.0085 0.0085
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Trypanosoma brucei Component of motile flagella 41 0.0146 0.0085 0.0188
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0332 0.0662 0.0662
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.0662
Onchocerca volvulus 0.0146 0.0087 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Onchocerca volvulus 0.0127 0.0028 0.0052
Schistosoma mansoni calpain-7 (C02 family) 0.1104 0.3055 0.3055
Trypanosoma brucei caltractin, putative 0.0151 0.0103 0.0248
Trypanosoma cruzi kinesin, putative 0.0772 0.2026 0.2026
Schistosoma mansoni cathepsin F (C01 family) 0.0127 0.0028 0.0028
Toxoplasma gondii centrin, putative 0.0146 0.0085 0.0188
Entamoeba histolytica calmodulin, putative 0.0146 0.0085 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2926 0.8703 0.8703
Echinococcus granulosus calpain A 0.1104 0.3055 0.3055
Echinococcus multilocularis calcium uptake protein 1 0.0146 0.0087 0.0059
Trichomonas vaginalis calcium binding protein, putative 0.0146 0.0085 0.0277
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Echinococcus granulosus EF hand domain containing family member A2 0.0146 0.0087 0.0087
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Trichomonas vaginalis calmodulin, putative 0.0146 0.0085 0.0277
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0332 0.0662 0.2089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1104 0.3055 0.3055
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0332 0.0662 0.2089
Leishmania major centrin, putative 0.0146 0.0085 0.0188
Echinococcus multilocularis calpain 0.1104 0.3055 0.3035
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0146 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma brucei calpain-like protein, putative 0.1104 0.3055 0.9966
Echinococcus multilocularis cathepsin b 0.3345 1 1
Trypanosoma brucei I/6 autoantigen 0.0146 0.0085 0.0188
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0146 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0146 0.0085 0.0085
Trypanosoma cruzi caltractin, putative 0.0146 0.0085 0.0085
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0146 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0146 0.0085 0.0277
Schistosoma mansoni cathepsin F (C01 family) 0.0127 0.0028 0.0028
Trichomonas vaginalis calcium binding proteins, putative 0.0146 0.0085 0.0277
Trypanosoma cruzi calmodulin, putative 0.0146 0.0085 0.0085
Echinococcus multilocularis hypothetical protein 0.1104 0.3055 0.3035
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1104 0.3055 0.3055
Loa Loa (eye worm) calpain family protein 1 0.2154 0.631 0.631
Loa Loa (eye worm) hypothetical protein 0.2154 0.631 0.631
Onchocerca volvulus 0.0146 0.0085 0.016
Brugia malayi calpain D 0.0332 0.0662 0.0662
Trypanosoma brucei calmodulin, putative 0.0146 0.0087 0.0195
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0332 0.0662 0.216
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0087 0.0196
Schistosoma mansoni calmodulin 0.0146 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Schistosoma mansoni neuronal calcium sensor 0.0146 0.0085 0.0085
Schistosoma mansoni rab 0.0146 0.0085 0.0085
Trypanosoma brucei calpain-like protein, putative 0.1104 0.3055 0.9966
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0028 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0028 0.0028
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0332 0.0662 0.0662
Entamoeba histolytica calpain large subunit domain III containing protein 0.0772 0.2026 1
Trypanosoma brucei hypothetical protein, conserved 0.0146 0.0085 0.0188
Trypanosoma brucei mitochondrial calcium uptake 1 0.0146 0.0085 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Brugia malayi programmed cell death protein 6 0.0146 0.0085 0.0085
Echinococcus multilocularis cathepsin b 0.3345 1 1
Entamoeba histolytica calcium-binding protein, putative 0.0146 0.0085 0.0418
Entamoeba histolytica calpain family cysteine protease, putative 0.0332 0.0662 0.3267
Loa Loa (eye worm) fibroinase 0.0127 0.0028 0.0028
Leishmania major hypothetical protein, conserved 0.0332 0.0662 0.2089
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0146 0.0085 0.0085
Brugia malayi Cathepsin L-like precursor 0.0127 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0028 0.009
Trypanosoma brucei Calpain-like protein 2 0.0332 0.0662 0.2089
Toxoplasma gondii calcium-dependent protein kinase 0.0146 0.0087 0.0195
Onchocerca volvulus 0.0127 0.0028 0.0052
Brugia malayi Cathepsin L-like precursor 0.0127 0.0028 0.0028

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.5 uM Inhibitory concentration against human cysteine protease cathepsin S ChEMBL. 15369380
IC50 (binding) = 9.5 uM Inhibitory concentration against human cysteine protease cathepsin S ChEMBL. 15369380

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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