TDR Targets

Basic information

Technical information

TDR Targets ID: 328493
Name: 5-hydroxy-2-phenyl-1H-quinolin-4-one
MW: 237.253 | Formula: C15H11NO2
H donors: 2 H acceptors: 3 LogP: 3.69 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cc(nc2c1c(O)ccc2)c1ccccc1
InChi: 1S/C15H11NO2/c17-13-8-4-7-11-15(13)14(18)9-12(16-11)10-5-2-1-3-6-10/h1-9,17H,(H,16,18)
InChiKey: YYSICMLHKRGBTP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-hydroxy-2-phenyl-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0088	0.0325	0.1004
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0196	0.0839	0.2592
Schistosoma mansoni	calmodulin	0.0088	0.0325	0.0325
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.004	0.0094	0.0094
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.9307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0064	0.0207	0.0641
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0064	0.0207	0.0207
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Echinococcus granulosus	EF hand domain containing family member A2	0.0088	0.0325	0.0325
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0088	0.0325	0.1564
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2117	1	1
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Entamoeba histolytica	cysteine proteinase, putative	0.0064	0.0207	0.0998
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Trichomonas vaginalis	calcium binding protein, putative	0.0094	0.0353	0.1092
Echinococcus granulosus	cathepsin l1	0.0064	0.0207	0.0207
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0064	0.0207	0.0998
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0088	0.0325	0.1004
Toxoplasma gondii	hypothetical protein	0.0196	0.0839	0.2369
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0064	0.0207	0.0641
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Schistosoma mansoni	cathepsin F (C01 family)	0.0064	0.0207	0.0207
Echinococcus granulosus	calcium uptake protein 1	0.0089	0.0327	0.0327
Echinococcus multilocularis	calmodulin	0.0088	0.0325	0.0325
Schistosoma mansoni	reticulocalbin	0.0089	0.0327	0.0327
Schistosoma mansoni	reticulocalbin	0.0088	0.0325	0.0325
Trypanosoma cruzi	centrin, putative	0.0094	0.0353	0.0353
Giardia lamblia	Cysteine protease	0.0064	0.0207	0.0641
Loa Loa (eye worm)	ctsf protein	0.0064	0.0207	0.0207
Onchocerca volvulus		0.0064	0.0207	0.0339
Plasmodium falciparum	calpain	0.0196	0.0839	1
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0218	0.0218
Echinococcus multilocularis	solute carrier family 5	0.004	0.0094	0.0094
Giardia lamblia	Cathepsin L precursor	0.0064	0.0207	0.0641
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.9307
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Loa Loa (eye worm)	fibroinase	0.0064	0.0207	0.0207
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0064	0.0207	0.0207
Schistosoma mansoni	neuronal calcium sensor	0.0088	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Leishmania major	calpain protease-like protein	0.0196	0.0839	0.2592
Echinococcus multilocularis	calpain 7 (C02 family)	0.0652	0.3012	0.3012
Trypanosoma brucei	Calpain-like protein 1.1	0.0196	0.0839	0.2592
Trypanosoma brucei	centrin-3	0.0094	0.0353	0.1092
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Echinococcus granulosus	lamin dm0	0.0028	0.0038	0.0038
Trichomonas vaginalis	calpain, putative	0.0196	0.0839	0.2592
Toxoplasma gondii	calmodulin CAM1	0.0089	0.0327	0.0742
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Trypanosoma brucei	hypothetical protein	0.0196	0.0839	0.2592
Leishmania major	centrin, putative,caltractin, putative	0.0088	0.0325	0.1004
Entamoeba histolytica	hypothetical protein	0.0064	0.0207	0.0998
Echinococcus granulosus	intermediate filament protein	0.0028	0.0038	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0207	0.0207
Trypanosoma brucei	calpain-like protein, putative	0.0652	0.3012	0.9307
Echinococcus granulosus	neuronal calcium sensor	0.0088	0.0325	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Leishmania major	protein kinase, putative	0.0088	0.0325	0.1004
Toxoplasma gondii	cathepsin B	0.0699	0.3236	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0196	0.0839	0.2592
Onchocerca volvulus	Cathepsin F homolog	0.0064	0.0207	0.0339
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.9307
Entamoeba histolytica	cysteine proteinase, putative	0.0064	0.0207	0.0998
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0196	0.0839	0.0839
Trypanosoma cruzi	caltractin, putative	0.0088	0.0325	0.0325
Schistosoma mansoni	calpain C (C02 family)	0.0652	0.3012	0.3012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0088	0.0325	0.1564
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0064	0.0207	0.0207
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0073	0.0073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0	0.5
Echinococcus granulosus	expressed protein	0.0387	0.1752	0.1752
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.1076	0.5035	0.5035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	myosin light chain 1, putative	0.0088	0.0325	0.1004
Onchocerca volvulus		0.0064	0.0207	0.0339
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0196	0.0839	0.0839
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0088	0.0325	0.1004
Plasmodium vivax	calpain, putative	0.0652	0.3012	1
Trypanosoma cruzi	conserved protein	0.0196	0.0839	0.0839
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0699	0.3236	1
Trichomonas vaginalis	calmodulin, putative	0.0089	0.0327	0.1012
Trichomonas vaginalis	calmodulin, putative	0.0094	0.0353	0.1092
Onchocerca volvulus	Cathepsin L homolog	0.0064	0.0207	0.0339
Entamoeba histolytica	cysteine proteinase, putative	0.0064	0.0207	0.0998
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0064	0.0207	0.0207
Trypanosoma cruzi	kinesin, putative	0.0456	0.2078	0.2078
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Schistosoma mansoni	ef hand domain family member A2	0.0088	0.0325	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Echinococcus multilocularis	geminin	0.0176	0.0743	0.0743
Echinococcus granulosus	cathepsin l1	0.0064	0.0207	0.0207
Schistosoma mansoni	calpain (C02 family)	0.0652	0.3012	0.3012
Schistosoma mansoni	inositol transporter	0.004	0.0094	0.0094
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1816	0.8563	0.8563
Onchocerca volvulus	Cathepsin L homolog	0.0064	0.0207	0.0339
Leishmania major	hypothetical protein, unknown function	0.0196	0.0839	0.2592
Toxoplasma gondii	cathepsin CPC2	0.0064	0.0207	0.036
Schistosoma mansoni	cathepsin F (C01 family)	0.0064	0.0207	0.0207
Echinococcus multilocularis	high affinity choline transporter 1	0.0361	0.1625	0.1625
Trichomonas vaginalis	calmodulin, putative	0.0088	0.0325	0.1004
Echinococcus granulosus	calbindin 32	0.0089	0.0327	0.0327
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Schistosoma mansoni	cathepsin C	0.0064	0.0207	0.0207
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0207	0.0207
Echinococcus multilocularis	programmed cell death protein	0.0094	0.0353	0.0353
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0652	0.3012	0.3012
Leishmania major	centrin, putative	0.0088	0.0325	0.1004
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0207	0.0641
Brugia malayi	calpain family protein 1	0.1728	0.8142	0.8142
Loa Loa (eye worm)	hypothetical protein	0.1728	0.8142	0.8142
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Schistosoma mansoni	cathepsin F (C01 family)	0.0064	0.0207	0.0207
Trypanosoma brucei	Calpain-like protein 2	0.0196	0.0839	0.2592
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0089	0.0327	0.0327
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Echinococcus granulosus	calpain	0.0652	0.3012	0.3012
Toxoplasma gondii	centrin, putative	0.0088	0.0325	0.0735
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0196	0.0839	0.2369
Leishmania major	calmodulin-like protein	0.0088	0.0325	0.1004
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0218	0.0218
Giardia lamblia	Hypothetical protein	0.0064	0.0207	0.0641
Onchocerca volvulus		0.0064	0.0207	0.0339
Leishmania major	programmed cell death 6 protein-like protein	0.0088	0.0325	0.1004
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0652	0.3012	0.3012
Echinococcus multilocularis	calcium uptake protein 1	0.0089	0.0327	0.0327
Echinococcus granulosus	high affinity choline transporter 1	0.0361	0.1625	0.1625
Echinococcus multilocularis	lamin dm0	0.0028	0.0038	0.0038
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0064	0.0207	0.0207
Trypanosoma cruzi	calmodulin, putative	0.0088	0.0325	0.0325
Entamoeba histolytica	calmodulin, putative	0.0088	0.0325	0.1564
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Giardia lamblia	Cathepsin B precursor	0.0699	0.3236	1
Trichomonas vaginalis	calcium binding protein, putative	0.0088	0.0325	0.1004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma brucei	calpain-like protein, putative	0.0652	0.3012	0.9307
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0088	0.0325	0.1004
Trichomonas vaginalis	calmodulin, putative	0.0088	0.0325	0.1004
Echinococcus multilocularis	EF hand domain containing family member A2	0.0089	0.0327	0.0327
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Loa Loa (eye worm)	hypothetical protein	0.2117	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Schistosoma mansoni	rab	0.0088	0.0325	0.0325
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1816	0.8563	0.8563
Toxoplasma gondii	cathepsin CPL	0.0064	0.0207	0.036
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0196	0.0839	0.2592
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0038	0.0038
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Schistosoma mansoni	hypothetical protein	0.0176	0.0743	0.0743
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0652	0.3012	0.3012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Giardia lamblia	Cathepsin B precursor	0.0699	0.3236	1
Onchocerca volvulus		0.004	0.0094	0.0113
Entamoeba histolytica	grainin 2	0.0094	0.0353	0.1701
Echinococcus multilocularis	hypothetical protein	0.0652	0.3012	0.3012
Loa Loa (eye worm)	cysteine protease	0.0064	0.0207	0.0207
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0088	0.0325	0.0325
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0196	0.0839	0.2592
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0064	0.0207	0.0207
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0218	0.0218
Onchocerca volvulus		0.0064	0.0207	0.0339
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0088	0.0325	0.042
Schistosoma mansoni	neuronal calcium sensor	0.0088	0.0325	0.0325
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Schistosoma mansoni	cathepsin S (C01 family)	0.0064	0.0207	0.0207
Leishmania major	calpain family cysteine protease-like protein	0.0196	0.0839	0.2592
Echinococcus granulosus	calumenin	0.0089	0.0327	0.0327
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0196	0.0839	0.0839
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Echinococcus multilocularis	cathepsin L cysteine protease	0.0064	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0094	0.0094
Loa Loa (eye worm)	cathepsin B	0.0699	0.3236	0.3236
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0652	0.3012	0.3012
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Schistosoma mansoni	hypothetical protein	0.0088	0.0325	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0064	0.0207	0.0641
Echinococcus multilocularis	cathepsin b	0.2117	1	1
Entamoeba histolytica	calpain family cysteine protease, putative	0.0196	0.0839	0.4036
Brugia malayi	cathepsin L-like cysteine proteinase	0.0064	0.0207	0.0207
Trichomonas vaginalis	calmodulin, putative	0.0088	0.0325	0.1004
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0196	0.0839	0.0839
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0064	0.0207	0.0207
Giardia lamblia	Cathepsin B precursor	0.0699	0.3236	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0064	0.0207	0.0207
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.004	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1625	0.1625
Schistosoma mansoni	centrin-related	0.0088	0.0325	0.0325
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0064	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Entamoeba histolytica	cysteine proteinase, putative	0.0064	0.0207	0.0998
Trypanosoma brucei	hypothetical protein, conserved	0.0088	0.0325	0.1004
Entamoeba histolytica	cysteine proteinase, putative	0.0064	0.0207	0.0998
Trichomonas vaginalis	calmodulin, putative	0.0088	0.0325	0.1004
Echinococcus granulosus	cathepsin b	0.2117	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Brugia malayi	calpain 5	0.0456	0.2078	0.2078
Toxoplasma gondii	centrin	0.0088	0.0325	0.0735
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Giardia lamblia	Cathepsin L precursor	0.0064	0.0207	0.0641
Brugia malayi	Calmodulin-like protein	0.0088	0.0325	0.0325
Schistosoma mansoni	calmodulin related calcium binding protein	0.0088	0.0325	0.0325
Trypanosoma cruzi	centrin, putative	0.0094	0.0353	0.0353
Trichomonas vaginalis	calcium binding protein, putative	0.0088	0.0325	0.1004
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.004	0.0094	0.0094
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0064	0.0207	0.0641
Brugia malayi	intermediate filament protein	0.0028	0.0038	0.0038
Entamoeba histolytica	calmodulin, putative	0.0088	0.0325	0.1564
Echinococcus multilocularis	EF hand domain containing family member A2	0.0088	0.0325	0.0325
Trypanosoma cruzi	major cysteine proteinase, putative	0.0064	0.0207	0.0207
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Echinococcus multilocularis	calumenin	0.0089	0.0327	0.0327
Trypanosoma cruzi	I/6 autoantigen, putative	0.0088	0.0325	0.0325
Echinococcus granulosus	neurocalcin	0.0088	0.0325	0.0325
Trypanosoma brucei	centrin, putative	0.0088	0.0325	0.1004
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Toxoplasma gondii	calcium-dependent protein kinase	0.0089	0.0327	0.0742
Trichomonas vaginalis	calcineurin B subunit, putative	0.0089	0.0327	0.1012
Leishmania major	kinesin, putative	0.0456	0.2078	0.6421
Giardia lamblia	Cysteine protease	0.0064	0.0207	0.0641
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0038	0.0038
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0196	0.0839	0.0839
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Echinococcus granulosus	centrin 2	0.0088	0.0325	0.0325
Brugia malayi	calpain family protein 1	0.1728	0.8142	0.8142
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0064	0.0207	0.0207
Entamoeba histolytica	cysteine proteinase, putative	0.0064	0.0207	0.0998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Loa Loa (eye worm)	programmed cell death protein 6	0.0089	0.0327	0.0327
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0064	0.0207	0.0207
Echinococcus granulosus	cathepsin b	0.2117	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0064	0.0207	0.0641
Trypanosoma brucei	Component of motile flagella 41	0.0088	0.0325	0.1004
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0064	0.0207	0.0207
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0699	0.3236	0.3236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Toxoplasma gondii	EFHC1, putative	0.0088	0.0325	0.0735
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0207	0.0207
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0064	0.0207	0.0207
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Schistosoma mansoni	neuronal calcium sensor	0.0088	0.0325	0.0325
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2117	1	1
Loa Loa (eye worm)	calpain D	0.0196	0.0839	0.0839
Brugia malayi	calcium-binding protein	0.0088	0.0325	0.0325
Giardia lamblia	Cathepsin L precursor	0.0064	0.0207	0.0641
Echinococcus multilocularis	cysteine protease	0.0064	0.0207	0.0207
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0699	0.3236	1
Trypanosoma cruzi	cysteine protease, putative	0.0064	0.0207	0.0207
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0652	0.3012	0.3012
Brugia malayi	cathepsin F-like cysteine proteinase	0.0064	0.0207	0.0207
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.1816	0.8563	0.8563
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	calcineurin B subunit, putative	0.0088	0.0325	0.1004
Plasmodium falciparum	centrin-1	0.0088	0.0325	0.1864
Trypanosoma cruzi	I/6 autoantigen, putative	0.0088	0.0325	0.0325
Leishmania major	calmodulin, putative	0.0088	0.0325	0.1004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0196	0.0839	0.0839
Giardia lamblia	Cathepsin L-like protease	0.0064	0.0207	0.0641
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0456	0.2078	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Schistosoma mansoni	cathepsin B (C01 family)	0.0064	0.0207	0.0207
Echinococcus granulosus	calmodulin	0.0088	0.0325	0.0325
Onchocerca volvulus	Cathepsin L homolog	0.0064	0.0207	0.0339
Echinococcus multilocularis	expressed protein	0.0387	0.1752	0.1752
Trypanosoma cruzi	cysteine proteinase, putative	0.0064	0.0207	0.0207
Giardia lamblia	Cathepsin L precursor	0.0064	0.0207	0.0641
Trypanosoma brucei	I/6 autoantigen	0.0088	0.0325	0.1004
Trichomonas vaginalis	centrin, putative	0.0088	0.0325	0.1004
Schistosoma mansoni	mitochondrial solute carrier	0.0088	0.0325	0.0325
Echinococcus multilocularis	calpain 5	0.0652	0.3012	0.3012
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Echinococcus multilocularis	cathepsin b	0.2117	1	1
Brugia malayi	EF hand family protein	0.0088	0.0325	0.0325
Trichomonas vaginalis	calmodulin, putative	0.0088	0.0325	0.1004
Trichomonas vaginalis	centrin, putative	0.0088	0.0325	0.1004
Trypanosoma brucei	centrin, putative	0.0088	0.0325	0.1004
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0088	0.0325	0.0325
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.3012
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0207	0.0207
Echinococcus granulosus	calpain 5	0.0652	0.3012	0.3012
Echinococcus multilocularis	calpain family protein 1, d	0.1272	0.5969	0.5969
Echinococcus multilocularis	calbindin 32	0.0089	0.0327	0.0327
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0064	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.1272	0.5969	0.5969
Echinococcus granulosus	lamin	0.0028	0.0038	0.0038
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Echinococcus granulosus	cathepsin L cysteine protease	0.0064	0.0207	0.0207
Schistosoma mansoni	hypothetical protein	0.0176	0.0743	0.0743
Loa Loa (eye worm)	calpain 5	0.0456	0.2078	0.2078
Entamoeba histolytica	cysteine proteinase 2	0.0064	0.0207	0.0998
Trypanosoma brucei	protein I/6	0.0088	0.0325	0.1004
Echinococcus multilocularis	calmodulin	0.0088	0.0325	0.0325
Loa Loa (eye worm)	calpain family protein 1	0.1728	0.8142	0.8142
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0089	0.0327	0.0327
Leishmania major	calcineurin B subunit, putative	0.0088	0.0325	0.1004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Echinococcus granulosus	calpain 7 C02 family	0.0652	0.3012	0.3012
Schistosoma mansoni	lamin	0.0028	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Echinococcus multilocularis	cysteine protease	0.0064	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0196	0.0839	0.0839
Schistosoma mansoni	hypothetical protein	0.0035	0.0073	0.0073
Trypanosoma brucei	calpain-like protein, putative	0.0652	0.3012	0.9307
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Trichomonas vaginalis	calpain, putative	0.0196	0.0839	0.2592
Schistosoma mansoni	hypothetical protein	0.0088	0.0325	0.0325
Leishmania major	hypothetical protein, conserved	0.0196	0.0839	0.2592
Trypanosoma brucei	calpain, putative	0.0196	0.0839	0.2592
Trypanosoma cruzi	centrin-3	0.0094	0.0353	0.0353
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0064	0.0207	0.0207
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Onchocerca volvulus		0.0089	0.0327	0.0579
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2117	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0207	0.0207
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Echinococcus granulosus	geminin	0.0176	0.0743	0.0743
Brugia malayi	TAR-binding protein	0.0066	0.0218	0.0218
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma brucei	Calpain-like protein 1.2	0.0196	0.0839	0.2592
Leishmania major	cathepsin L-like protease	0.0064	0.0207	0.0641
Echinococcus multilocularis	calpain	0.0652	0.3012	0.3012
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0699	0.3236	0.3236
Echinococcus granulosus	cathepsin L	0.0064	0.0207	0.0207
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0064	0.0207	0.0641
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0325	0.1004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0196	0.0839	0.0839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Trypanosoma cruzi	cysteine proteinase, putative	0.0064	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0218	0.0218
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Entamoeba histolytica	hypothetical protein, conserved	0.0089	0.0327	0.1575
Giardia lamblia	Hypothetical protein	0.0089	0.0327	0.1012
Echinococcus granulosus	calpain A	0.1816	0.8565	0.8565
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0088	0.0325	0.0325
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Loa Loa (eye worm)	calpain family protein 1	0.1272	0.5969	0.5969
Brugia malayi	RNA binding protein	0.0066	0.0218	0.0218
Entamoeba histolytica	calcium binding family protein	0.0088	0.0325	0.1564
Echinococcus multilocularis	cathepsin L	0.0064	0.0207	0.0207
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0196	0.0839	0.2592
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.3012
Brugia malayi	EF hand family protein	0.0089	0.0327	0.0327
Schistosoma mansoni	calpain-7 (C02 family)	0.0652	0.3012	0.3012
Giardia lamblia	Cathepsin B precursor	0.0064	0.0207	0.0641
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0064	0.0207	0.0998
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Trypanosoma brucei	antigen, putative	0.0652	0.3012	0.9307
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Onchocerca volvulus		0.0064	0.0207	0.0339
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Echinococcus multilocularis	centrin 2	0.0088	0.0325	0.0325
Trypanosoma cruzi	calmodulin, putative	0.0088	0.0325	0.0325
Trypanosoma brucei	calmodulin, putative	0.0089	0.0327	0.1012
Toxoplasma gondii	cathepsin CPC1	0.0064	0.0207	0.036
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0064	0.0207	0.0641
Giardia lamblia	Cathepsin B precursor	0.0064	0.0207	0.0641
Trypanosoma brucei	kinesin, putative	0.0456	0.2078	0.6421
Leishmania major	hypothetical protein, conserved	0.0088	0.0325	0.1004
Giardia lamblia	Cathepsin B precursor	0.0064	0.0207	0.0641
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0196	0.0839	0.0839
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0218	0.0218
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Trypanosoma brucei	calpain, putative	0.0196	0.0839	0.2592
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0064	0.0207	0.0207
Entamoeba histolytica	grainin, putative	0.0089	0.0327	0.1575
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Brugia malayi	Sodium:solute symporter family protein	0.004	0.0094	0.0094
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0064	0.0207	0.0207
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0064	0.0207	0.036
Echinococcus multilocularis	cathepsin L cysteine protease	0.0064	0.0207	0.0207
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Giardia lamblia	Hypothetical protein	0.0064	0.0207	0.0641
Schistosoma mansoni	calpain-7 (C02 family)	0.0652	0.3012	0.3012
Trichomonas vaginalis	calpain, putative	0.0196	0.0839	0.2592
Onchocerca volvulus		0.0088	0.0325	0.0575
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0064	0.0207	0.0641
Giardia lamblia	Cathepsin L precursor	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0196	0.0839	0.2592
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Brugia malayi	calpain 5	0.0196	0.0839	0.0839
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1728	0.8142	0.8142
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0196	0.0839	0.0839
Trypanosoma cruzi	kinesin, putative	0.0456	0.2078	0.2078
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0196	0.0839	0.0839
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0064	0.0207	0.0207
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.004	0.0094	0.0094
Entamoeba histolytica	cysteine proteinase, putative	0.0064	0.0207	0.0998
Giardia lamblia	Cathepsin L precursor	0.0064	0.0207	0.0641
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0196	0.0839	0.2592
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Echinococcus granulosus	EF hand domain containing family member A2	0.0089	0.0327	0.0327
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0064	0.0207	0.0207
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0652	0.3012	0.9307
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.1816	0.8563	0.8563
Loa Loa (eye worm)	EF hand family protein	0.0088	0.0325	0.0325
Schistosoma mansoni	high-affinity choline transporter	0.0361	0.1625	0.1625
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0088	0.0325	0.0325
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2117	1	1
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Trichomonas vaginalis	calmodulin-2, putative	0.0088	0.0325	0.1004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Schistosoma mansoni	calpain-2 (C02 family)	0.0196	0.0839	0.0839
Toxoplasma gondii	EF hand domain-containing protein	0.0088	0.0325	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0151	0.0151
Echinococcus granulosus	sodium:myo inositol cotransporter	0.004	0.0094	0.0094
Entamoeba histolytica	cysteine proteinase 1, putative	0.0064	0.0207	0.0998
Plasmodium vivax	centrin-1, putative	0.0088	0.0325	0.042
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.3012
Giardia lamblia	Cysteine protease	0.0064	0.0207	0.0641
Leishmania major	calmodulin-like protein	0.0088	0.0325	0.1004
Trichomonas vaginalis	calcium binding protein, putative	0.0088	0.0325	0.1004
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0652	0.3012	0.3012
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Echinococcus multilocularis	lamin	0.0028	0.0038	0.0038
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0088	0.0325	0.0325
Schistosoma mansoni	neuronal calcium sensor	0.0088	0.0325	0.0325
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0064	0.0207	0.0207
Echinococcus granulosus	sodium:glucose cotransporter 2	0.004	0.0094	0.0094
Onchocerca volvulus		0.0064	0.0207	0.0339
Trichomonas vaginalis	hypothetical protein	0.0196	0.0839	0.2592
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0207	0.0641
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0064	0.0207	0.0207
Onchocerca volvulus		0.0064	0.0207	0.0339
Leishmania major	cysteine peptidase A (CPA)	0.0064	0.0207	0.0641
Brugia malayi	Papain family cysteine protease containing protein	0.0064	0.0207	0.0207
Schistosoma mansoni	hypothetical protein	0.0196	0.0839	0.0839
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0088	0.0325	0.0325
Echinococcus multilocularis	programmed cell death protein	0.0094	0.0353	0.0353
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0064	0.0207	0.0207
Trichomonas vaginalis	conserved hypothetical protein	0.0196	0.0839	0.2592
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Trypanosoma cruzi	calmodulin, putative	0.0088	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0218	0.0218
Leishmania major	hypothetical protein, conserved	0.0089	0.0327	0.1012
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0038	0.0038
Brugia malayi	calpain 7	0.0652	0.3012	0.3012
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0325	0.1004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0207	0.0641
Schistosoma mansoni	inositol transporter	0.004	0.0094	0.0094
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0088	0.0325	0.0325
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0207	0.0207
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0218	0.0218
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0064	0.0207	0.0207
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.0839
Onchocerca volvulus		0.0064	0.0207	0.0339
Trypanosoma cruzi	major cysteine proteinase, putative	0.0064	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Trypanosoma brucei	calpain-like protein, putative	0.0652	0.3012	0.9307
Entamoeba histolytica	calcium-binding protein, putative	0.0088	0.0325	0.1564
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Echinococcus multilocularis	neuronal calcium sensor	0.0088	0.0325	0.0325
Onchocerca volvulus		0.0064	0.0207	0.0339
Echinococcus granulosus	programmed cell death protein	0.0094	0.0353	0.0353
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Echinococcus multilocularis	cathepsin L	0.0064	0.0207	0.0207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Schistosoma mansoni	lamin	0.0028	0.0038	0.0038
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0038	0.0038
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0088	0.0325	0.1004
Brugia malayi	GH02984p	0.0361	0.1625	0.1625
Trypanosoma brucei	caltractin, putative	0.0094	0.0353	0.1092
Leishmania major	phospholipase c-like protein	0.0088	0.0325	0.1004
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0196	0.0839	0.2592
Giardia lamblia	Cathepsin B precursor	0.0064	0.0207	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0325	0.0325
Giardia lamblia	Cathepsin L-like protease	0.0064	0.0207	0.0641
Brugia malayi	cathepsin L precursor	0.0064	0.0207	0.0207
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Plasmodium vivax	hypothetical protein, conserved	0.0089	0.0327	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Trichomonas vaginalis	calcium binding proteins, putative	0.0088	0.0325	0.1004
Echinococcus multilocularis	musashi	0.0028	0.0038	0.0038
Brugia malayi	cathepsin L-like precursor	0.0064	0.0207	0.0207
Trichomonas vaginalis	calmodulin, putative	0.0088	0.0325	0.1004
Schistosoma mansoni	sodium/solute symporter	0.004	0.0094	0.0094
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0699	0.3236	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0218	0.0218
Giardia lamblia	Cathepsin B precursor	0.0064	0.0207	0.0641
Entamoeba histolytica	cysteine protease, putative	0.0064	0.0207	0.0998
Onchocerca volvulus		0.0088	0.0325	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0325	0.0325
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0218	0.0218
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0196	0.0839	0.2592
Giardia lamblia	Encystation-specific protease	0.0064	0.0207	0.0641
Brugia malayi	fibroinase precursor	0.0064	0.0207	0.0207
Brugia malayi	calpain D	0.0196	0.0839	0.0839
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0064	0.0207	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Echinococcus multilocularis	calpain A	0.1816	0.8565	0.8565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Entamoeba histolytica	protein kinase, putative	0.0456	0.2078	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0036	0.0036
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0088	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Echinococcus granulosus	solute carrier family 5	0.004	0.0094	0.0094
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.9307
Echinococcus granulosus	cathepsin L	0.0064	0.0207	0.0207
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0218	0.0218
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0196	0.0839	0.2592
Echinococcus granulosus	cysteine protease	0.0064	0.0207	0.0207
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2117	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0064	0.0207	0.0641
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0064	0.0207	0.0207
Trypanosoma brucei	cysteine peptidase, putative	0.0196	0.0839	0.2592
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0088	0.0325	0.0325
Loa Loa (eye worm)	calpain	0.0652	0.3012	0.3012
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0151	0.0151
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0088	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.1532	0.7208	0.7208
Trypanosoma brucei	calmodulin, putative	0.0088	0.0325	0.1004
Giardia lamblia	Cysteine protease	0.0064	0.0207	0.0641
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Trichomonas vaginalis	calmodulin, putative	0.0088	0.0325	0.1004
Onchocerca volvulus		0.1076	0.5035	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0652	0.3012	0.3012
Schistosoma mansoni	centrin	0.0088	0.0325	0.0325
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0196	0.0839	0.2592
Loa Loa (eye worm)	calmodulin-like protein	0.0088	0.0325	0.0325
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0151	0.0151
Echinococcus granulosus	sodium:glucose cotransporter	0.004	0.0094	0.0094
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0038	0.0038
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0088	0.0325	0.0735
Schistosoma mansoni	calmodulin	0.0088	0.0325	0.0325
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0207	0.0207
Leishmania major	calmodulin, putative	0.0088	0.0325	0.1004
Brugia malayi	programmed cell death protein 6	0.0088	0.0325	0.0325
Echinococcus granulosus	calpain A	0.0652	0.3012	0.3012
Leishmania major	i/6 autoantigen-like protein	0.0088	0.0325	0.1004
Leishmania major	centrin, putative	0.0088	0.0325	0.1004
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0652	0.3012	0.3012
Echinococcus multilocularis	neurocalcin	0.0088	0.0325	0.0325

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 21 %	Ability of the compound to induce cells in G2/M phase	ChEMBL.	15369401
Activity (functional)	= 21 %	Ability of the compound to induce cells in G2/M phase	ChEMBL.	15369401
Activity (functional)	= 26 %	Ability of the compound to induce cells in G0/G1 phase	ChEMBL.	15369401
Activity (functional)	= 26 %	Ability of the compound to induce cells in G0/G1 phase	ChEMBL.	15369401
Activity (functional)	= 52 %	Ability of the compound to induce cells in S phase	ChEMBL.	15369401
Activity (functional)	= 52 %	Ability of the compound to induce cells in S phase	ChEMBL.	15369401

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11241863

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 328493