Detailed information for compound 328793

Basic information

Technical information
  • TDR Targets ID: 328793
  • Name: (3-benzoyl-2,6-dihydroxyphenyl)-phenylmethano ne
  • MW: 318.323 | Formula: C20H14O4
  • H donors: 2 H acceptors: 4 LogP: 4.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1O)C(=O)c1ccccc1)O)c1ccccc1
  • InChi: 1S/C20H14O4/c21-16-12-11-15(18(22)13-7-3-1-4-8-13)20(24)17(16)19(23)14-9-5-2-6-10-14/h1-12,21,24H
  • InChiKey: KOKLAVMEUFYRKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3-benzoyl-2,6-dihydroxy-phenyl)-phenyl-methanone
  • [2,6-dihydroxy-3-(phenylcarbonyl)phenyl]-phenyl-methanone
  • [3-(benzoyl)-2,6-dihydroxyphenyl]-phenylmethanone
  • [3-(benzoyl)-2,6-dihydroxy-phenyl]-phenyl-methanone
  • [2,6-dihydroxy-3-(oxo-phenylmethyl)phenyl]-phenylmethanone
  • (2,6-dihydroxy-3-phenylcarbonyl-phenyl)-phenyl-methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Ovis aries Cyclooxygenase-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, putative 0.016 0.0664 0.2147
Loa Loa (eye worm) hypothetical protein 0.0239 0.114 0.114
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0533 0.2928 0.9467
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trichomonas vaginalis calpain, putative 0.016 0.0664 0.2147
Echinococcus multilocularis hypothetical protein 0.0533 0.2928 0.2928
Schistosoma mansoni neuronal calcium sensor 0.0064 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0664 0.2147
Trypanosoma brucei mitochondrial calcium uptake 1 0.0064 0.0079 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.056 0.3093 0.3093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.016 0.0664 0.0664
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0533 0.2928 0.2928
Trichomonas vaginalis calpain, putative 0.016 0.0664 0.2147
Schistosoma mansoni ef hand domain family member A2 0.0064 0.0079 0.0079
Loa Loa (eye worm) calpain D 0.016 0.0664 0.0664
Entamoeba histolytica calpain family cysteine protease, putative 0.016 0.0664 0.3396
Leishmania major centrin, putative,caltractin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0533 0.2928 0.2928
Trypanosoma brucei calmodulin, putative 0.0064 0.0079 0.0257
Echinococcus granulosus calmodulin 0.0064 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.016 0.0664 0.2147
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Echinococcus granulosus calpain 7 C02 family 0.0533 0.2928 0.2928
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0064 0.0079 0.0079
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1413 0.8273 0.8273
Trypanosoma brucei calpain-like protein, putative 0.0533 0.2928 0.9467
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0064 0.0079 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Echinococcus multilocularis calpain 7 (C02 family) 0.0533 0.2928 0.2928
Trichomonas vaginalis centrin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi kinesin, putative 0.0373 0.1955 0.1955
Trypanosoma cruzi centrin, putative 0.0064 0.0079 0.0079
Onchocerca volvulus 0.0064 0.0079 0.0158
Loa Loa (eye worm) calpain family protein 1 0.104 0.6008 0.6008
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.016 0.0664 0.2147
Trypanosoma brucei antigen, putative 0.0533 0.2928 0.9467
Loa Loa (eye worm) hypothetical protein 0.104 0.6008 0.6008
Loa Loa (eye worm) calmodulin-like protein 0.0064 0.0079 0.0079
Schistosoma mansoni reticulocalbin 0.0064 0.0079 0.0079
Trichomonas vaginalis calcium binding protein, putative 0.0064 0.0079 0.0257
Brugia malayi Calmodulin-like protein 0.0064 0.0079 0.0079
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.9467
Echinococcus multilocularis calpain 0.0533 0.2928 0.2928
Loa Loa (eye worm) hypothetical protein 0.1698 1 1
Leishmania major i/6 autoantigen-like protein 0.0064 0.0079 0.0257
Schistosoma mansoni calmodulin related calcium binding protein 0.0064 0.0079 0.0079
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0064 0.0079 0.0257
Echinococcus multilocularis centrin 2 0.0064 0.0079 0.0079
Trypanosoma cruzi I/6 autoantigen, putative 0.0064 0.0079 0.0079
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.114 0.114
Leishmania major centrin, putative 0.0064 0.0079 0.0257
Schistosoma mansoni calpain-2 (C02 family) 0.016 0.0664 0.0664
Schistosoma mansoni neuronal calcium sensor 0.0064 0.0079 0.0079
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Leishmania major centrin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi caltractin, putative 0.0064 0.0079 0.0079
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0064 0.0079 0.0257
Trypanosoma brucei calmodulin, putative 0.0064 0.0079 0.0257
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0079 0.0257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1698 1 1
Echinococcus multilocularis calmodulin 0.0064 0.0079 0.0079
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Brugia malayi calpain 5 0.0373 0.1955 0.1955
Trypanosoma brucei caltractin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0064 0.0079 0.0079
Trichomonas vaginalis calpain, putative 0.016 0.0664 0.2147
Toxoplasma gondii EFHC1, putative 0.0064 0.0079 0.0257
Schistosoma mansoni hypothetical protein 0.0064 0.0079 0.0079
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0064 0.0079 0.0406
Schistosoma mansoni centrin 0.0064 0.0079 0.0079
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.9467
Brugia malayi hypothetical protein 0.0239 0.114 0.114
Plasmodium falciparum calpain 0.016 0.0664 1
Brugia malayi calpain 7 0.0533 0.2928 0.2928
Loa Loa (eye worm) hypothetical protein 0.0064 0.0079 0.0079
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.016 0.0664 0.0664
Trichomonas vaginalis calcineurin B subunit, putative 0.0064 0.0079 0.0257
Leishmania major calpain family cysteine protease-like protein 0.016 0.0664 0.2147
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.016 0.0664 0.0664
Schistosoma mansoni calpain C (C02 family) 0.0533 0.2928 0.2928
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Echinococcus multilocularis programmed cell death protein 0.0064 0.0079 0.0079
Echinococcus granulosus neuronal calcium sensor 0.0064 0.0079 0.0079
Entamoeba histolytica protein kinase, putative 0.0373 0.1955 1
Entamoeba histolytica calmodulin, putative 0.0064 0.0079 0.0406
Trypanosoma cruzi calpain cysteine peptidase, putative 0.016 0.0664 0.0664
Toxoplasma gondii centrin, putative 0.0064 0.0079 0.0257
Toxoplasma gondii hypothetical protein 0.016 0.0664 0.2147
Echinococcus granulosus calpain A 0.0533 0.2928 0.2928
Echinococcus granulosus EF HAND 1 calcium binding site 0.0064 0.0079 0.0079
Loa Loa (eye worm) calpain family protein 1 0.1413 0.8273 0.8273
Leishmania major calmodulin-like protein 0.0064 0.0079 0.0257
Loa Loa (eye worm) hypothetical protein 0.1413 0.8273 0.8273
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.016 0.0664 0.0664
Schistosoma mansoni calmodulin 0.0064 0.0079 0.0079
Echinococcus multilocularis programmed cell death protein 0.0064 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.016 0.0664 0.2147
Echinococcus multilocularis calcium uptake protein 1 0.0064 0.0079 0.0079
Trichomonas vaginalis calmodulin-2, putative 0.0064 0.0079 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0533 0.2928 0.2928
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0533 0.2928 0.2928
Entamoeba histolytica grainin 2 0.0064 0.0079 0.0406
Leishmania major hypothetical protein, conserved 0.0064 0.0079 0.0257
Onchocerca volvulus 0.0064 0.0079 0.0158
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.2928
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0533 0.2928 0.2928
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0064 0.0079 0.0079
Echinococcus multilocularis geminin 0.0171 0.0729 0.0729
Echinococcus multilocularis calpain family protein 1, d 0.104 0.6008 0.6008
Echinococcus multilocularis neuronal calcium sensor 0.0064 0.0079 0.0079
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0064 0.0079 0.0406
Trypanosoma brucei calpain-like protein, putative 0.0533 0.2928 0.9467
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1477 0.8661 0.8661
Trypanosoma brucei Calpain-like protein CALP1.3 0.016 0.0664 0.2147
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trypanosoma brucei kinesin, putative 0.0373 0.1955 0.632
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Echinococcus multilocularis calbindin 32 0.0064 0.0079 0.0079
Echinococcus multilocularis calmodulin 0.0064 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0079 0.0257
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1477 0.8661 0.8661
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trichomonas vaginalis calcium binding protein, putative 0.0064 0.0079 0.0257
Trichomonas vaginalis centrin, putative 0.0064 0.0079 0.0257
Brugia malayi EF hand family protein 0.0064 0.0079 0.0079
Echinococcus granulosus calpain 5 0.0533 0.2928 0.2928
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.016 0.0664 0.0664
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.056 0.3093 0.3093
Schistosoma mansoni hypothetical protein 0.0171 0.0729 0.0729
Trichomonas vaginalis hypothetical protein 0.016 0.0664 0.2147
Loa Loa (eye worm) cathepsin B 0.056 0.3093 0.3093
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.9467
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0079 0.0271
Brugia malayi calpain D 0.016 0.0664 0.0664
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1698 1 1
Loa Loa (eye worm) hypothetical protein 0.088 0.5035 0.5035
Echinococcus multilocularis calumenin 0.0064 0.0079 0.0079
Leishmania major protein kinase, putative 0.0064 0.0079 0.0257
Loa Loa (eye worm) hypothetical protein 0.0064 0.0079 0.0079
Trypanosoma brucei I/6 autoantigen 0.0064 0.0079 0.0257
Trypanosoma brucei calpain-like protein, putative 0.0533 0.2928 0.9467
Trypanosoma brucei protein I/6 0.0064 0.0079 0.0257
Trichomonas vaginalis calcium binding protein, putative 0.0064 0.0079 0.0257
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.114 0.114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Giardia lamblia Cathepsin B precursor 0.056 0.3093 1
Echinococcus multilocularis cathepsin b 0.1698 1 1
Entamoeba histolytica calcium-binding protein, putative 0.0064 0.0079 0.0406
Trypanosoma brucei Calpain-like protein 1.2 0.016 0.0664 0.2147
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0079 0.0257
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.016 0.0664 0.0664
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.056 0.3093 1
Echinococcus multilocularis EF hand domain containing family member A2 0.0064 0.0079 0.0079
Schistosoma mansoni calpain-7 (C02 family) 0.0533 0.2928 0.2928
Plasmodium vivax calpain, putative 0.0533 0.2928 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0664 0.0664
Brugia malayi programmed cell death protein 6 0.0064 0.0079 0.0079
Leishmania major programmed cell death 6 protein-like protein 0.0064 0.0079 0.0257
Schistosoma mansoni hypothetical protein 0.016 0.0664 0.0664
Toxoplasma gondii centrin 0.0064 0.0079 0.0257
Leishmania major hypothetical protein, conserved 0.016 0.0664 0.2147
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Onchocerca volvulus 0.0064 0.0079 0.0158
Brugia malayi EF hand family protein 0.0064 0.0079 0.0079
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.016 0.0664 0.2147
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0064 0.0079 0.0257
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.016 0.0664 0.2147
Schistosoma mansoni hypothetical protein 0.0064 0.0079 0.0079
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0064 0.0079 0.0079
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.016 0.0664 0.0664
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.016 0.0664 0.2147
Leishmania major hypothetical protein, unknown function 0.016 0.0664 0.2147
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0064 0.0079 0.0079
Trypanosoma brucei calpain, putative 0.016 0.0664 0.2147
Brugia malayi calpain 5 0.016 0.0664 0.0664
Trypanosoma brucei Component of motile flagella 41 0.0064 0.0079 0.0257
Leishmania major calmodulin, putative 0.0064 0.0079 0.0257
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.9467
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.016 0.0664 0.0664
Echinococcus granulosus programmed cell death protein 0.0064 0.0079 0.0079
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Schistosoma mansoni calpain (C02 family) 0.0533 0.2928 0.2928
Trypanosoma brucei cysteine peptidase C (CPC) 0.056 0.3093 1
Trypanosoma cruzi calmodulin, putative 0.0064 0.0079 0.0079
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.2928
Trypanosoma brucei hypothetical protein 0.016 0.0664 0.2147
Entamoeba histolytica calmodulin, putative 0.0064 0.0079 0.0406
Entamoeba histolytica hypothetical protein, conserved 0.0064 0.0079 0.0406
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1477 0.8661 0.8661
Echinococcus granulosus neurocalcin 0.0064 0.0079 0.0079
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.016 0.0664 0.2147
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0533 0.2928 0.2928
Echinococcus granulosus geminin 0.0171 0.0729 0.0729
Schistosoma mansoni calmodulin 0.0064 0.0079 0.0079
Echinococcus multilocularis cathepsin b 0.1698 1 1
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0064 0.0079 0.0079
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1477 0.8661 0.8661
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Echinococcus granulosus cathepsin b 0.1698 1 1
Schistosoma mansoni rab 0.0064 0.0079 0.0079
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Echinococcus granulosus calpain 0.0533 0.2928 0.2928
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Trypanosoma cruzi calmodulin, putative 0.0064 0.0079 0.0079
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Trypanosoma brucei calpain-like protein, putative 0.0533 0.2928 0.9467
Trichomonas vaginalis calcineurin B subunit, putative 0.0064 0.0079 0.0257
Echinococcus multilocularis neurocalcin 0.0064 0.0079 0.0079
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Brugia malayi calpain family protein 1 0.1413 0.8273 0.8273
Entamoeba histolytica calpain large subunit domain III containing protein 0.0373 0.1955 1
Leishmania major calpain protease-like protein 0.016 0.0664 0.2147
Trypanosoma brucei centrin-3 0.0064 0.0079 0.0257
Leishmania major calcineurin B subunit, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Giardia lamblia Cathepsin B precursor 0.056 0.3093 1
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0064 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.016 0.0664 0.2147
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0064 0.0079 0.0079
Giardia lamblia Cathepsin B precursor 0.056 0.3093 1
Loa Loa (eye worm) calpain 0.0533 0.2928 0.2928
Schistosoma mansoni calpain-7 (C02 family) 0.0533 0.2928 0.2928
Echinococcus granulosus calpain A 0.1477 0.8661 0.8661
Leishmania major hypothetical protein, conserved 0.0064 0.0079 0.0257
Toxoplasma gondii calmodulin CAM1 0.0064 0.0079 0.0257
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0079 0.0271
Schistosoma mansoni Mername-AA248 (C02 family) 0.0533 0.2928 0.2928
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.016 0.0664 0.0664
Plasmodium vivax centrin-1, putative 0.0064 0.0079 0.0271
Echinococcus granulosus EF hand domain containing family member A2 0.0064 0.0079 0.0079
Toxoplasma gondii cathepsin B 0.056 0.3093 1
Leishmania major phospholipase c-like protein 0.0064 0.0079 0.0257
Toxoplasma gondii EF hand domain-containing protein 0.0064 0.0079 0.0257
Schistosoma mansoni reticulocalbin 0.0064 0.0079 0.0079
Trichomonas vaginalis calcium binding protein, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1698 1 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0064 0.0079 0.0079
Trichomonas vaginalis myosin light chain 1, putative 0.0064 0.0079 0.0257
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1698 1 1
Echinococcus granulosus calumenin 0.0064 0.0079 0.0079
Onchocerca volvulus 0.088 0.5035 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.2928
Trypanosoma cruzi conserved protein 0.016 0.0664 0.0664
Schistosoma mansoni mitochondrial solute carrier 0.0064 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.1253 0.7299 0.7299
Schistosoma mansoni neuronal calcium sensor 0.0064 0.0079 0.0079
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0064 0.0079 0.0079
Trypanosoma brucei calpain, putative 0.016 0.0664 0.2147
Echinococcus granulosus calbindin 32 0.0064 0.0079 0.0079
Trypanosoma brucei centrin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0533 0.2928 0.2928
Brugia malayi calpain family protein 1 0.1413 0.8273 0.8273
Toxoplasma gondii troponin c, isotype gamma, putative 0.0064 0.0079 0.0257
Schistosoma mansoni centrin-related 0.0064 0.0079 0.0079
Echinococcus multilocularis calpain 5 0.0533 0.2928 0.2928
Trypanosoma brucei Calpain-like protein 2 0.016 0.0664 0.2147
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.016 0.0664 0.2147
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1698 1 1
Echinococcus granulosus calcium uptake protein 1 0.0064 0.0079 0.0079
Echinococcus multilocularis EF hand domain containing family member A2 0.0064 0.0079 0.0079
Trichomonas vaginalis calcium binding proteins, putative 0.0064 0.0079 0.0257
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi kinesin, putative 0.0373 0.1955 0.1955
Leishmania major kinesin, putative 0.0373 0.1955 0.632
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Loa Loa (eye worm) programmed cell death protein 6 0.0064 0.0079 0.0079
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.2147
Schistosoma mansoni neuronal calcium sensor 0.0064 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.016 0.0664 0.2147
Echinococcus multilocularis calpain A 0.1477 0.8661 0.8661
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.056 0.3093 1
Trypanosoma brucei centrin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi centrin, putative 0.0064 0.0079 0.0079
Trypanosoma cruzi calmodulin, putative 0.0064 0.0079 0.0079
Loa Loa (eye worm) EF hand family protein 0.0064 0.0079 0.0079
Brugia malayi calcium-binding protein 0.0064 0.0079 0.0079
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi I/6 autoantigen, putative 0.0064 0.0079 0.0079
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.016 0.0664 0.0664
Leishmania major calmodulin, putative 0.0064 0.0079 0.0257
Echinococcus granulosus EF hand domain containing family member A2 0.0064 0.0079 0.0079
Entamoeba histolytica calcium binding family protein 0.0064 0.0079 0.0406
Trichomonas vaginalis calmodulin, putative 0.0064 0.0079 0.0257
Trypanosoma cruzi centrin-3 0.0064 0.0079 0.0079
Echinococcus granulosus centrin 2 0.0064 0.0079 0.0079
Entamoeba histolytica grainin, putative 0.0064 0.0079 0.0406
Plasmodium falciparum centrin-1 0.0064 0.0079 0.1195
Leishmania major calmodulin-like protein 0.0064 0.0079 0.0257
Giardia lamblia Hypothetical protein 0.0064 0.0079 0.0257
Schistosoma mansoni hypothetical protein 0.0171 0.0729 0.0729
Trypanosoma brucei Calpain-like protein 1.1 0.016 0.0664 0.2147
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0064 0.0079 0.0257
Echinococcus granulosus cathepsin b 0.1698 1 1
Loa Loa (eye worm) calpain 5 0.0373 0.1955 0.1955
Toxoplasma gondii calcium-dependent protein kinase 0.0064 0.0079 0.0257

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6 uM In vitro inhibitory activity against ovine cyclooxygenase-1 (COX-1) ChEMBL. 15369391
IC50 (binding) = 6 uM In vitro inhibitory activity against ovine cyclooxygenase-1 (COX-1) ChEMBL. 15369391

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.