TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 285.27 | Formula: C16H12FNO3
H donors: 2 H acceptors: 3 LogP: 3.89 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C=CCc1cc(O)cc2c1oc(n2)c1ccc(cc1F)O
InChi: 1S/C16H12FNO3/c1-2-3-9-6-11(20)8-14-15(9)21-16(18-14)12-5-4-10(19)7-13(12)17/h2,4-8,19-20H,1,3H2
InChiKey: RFGHIDZADADSIN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	estrogen receptor 1	Starlite/ChEMBL	References
Homo sapiens	estrogen receptor 2 (ER beta)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	hypothetical protein	estrogen receptor 2 (ER beta)	495 aa	418 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neurocalcin	0.0199	0.0202	0.0092
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0266	0.0353	0.0353
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3553	0.7812	0.7788
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Loa Loa (eye worm)	hypothetical protein	0.016	0.0114	0.0114
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0111	0.0111
Brugia malayi	calpain 5	0.0891	0.1772	0.168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Echinococcus multilocularis	centrin 2	0.0199	0.0202	0.0092
Onchocerca volvulus		0.0266	0.0353	0.055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Trypanosoma brucei	Calpain-like protein 2	0.0359	0.0563	0.1218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.125	0.2586	0.2503
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0111	0.0111
Entamoeba histolytica	cysteine proteinase, putative	0.0202	0.0209	0.0592
Echinococcus granulosus	calpain 5	0.125	0.2586	0.2503
Trichomonas vaginalis	hypothetical protein	0.0359	0.0563	0.148
Echinococcus multilocularis	calmodulin	0.0199	0.0202	0.0092
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.3553	0.7812	0.7788
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0359	0.0563	0.0458
Onchocerca volvulus	Cathepsin L homolog	0.0266	0.0353	0.055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Schistosoma mansoni	neuronal calcium sensor	0.0199	0.0202	0.0092
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.0209	0.01
Loa Loa (eye worm)	calpain family protein 1	0.2463	0.5338	0.5338
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0243	0.0301	0.1147
Entamoeba histolytica	grainin, putative	0.0202	0.0208	0.0588
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0266	0.0353	0.0245
Loa Loa (eye worm)	EF hand family protein	0.0199	0.0202	0.0202
Loa Loa (eye worm)	hypothetical protein	0.4518	1	1
Loa Loa (eye worm)	hypothetical protein	0.2104	0.4524	0.4524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Trypanosoma cruzi	calmodulin, putative	0.0199	0.0202	0.0092
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.016	0.0114	0.0003
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0199	0.0202	0.0298
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1507	0.3169	0.3093
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Echinococcus multilocularis	neuronal calcium sensor	0.0199	0.0202	0.0092
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.8034
Trichomonas vaginalis	calmodulin, putative	0.0222	0.0253	0.0467
Leishmania major	hypothetical protein, unknown function	0.0359	0.0563	0.1218
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.125	0.2586	0.8034
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1507	0.3169	1
Giardia lamblia	Hypothetical protein	0.0202	0.0208	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0202	0.0202
Echinococcus multilocularis	cathepsin L	0.0202	0.0209	0.01
Echinococcus granulosus	centrin 2	0.0199	0.0202	0.0092
Toxoplasma gondii	hypothetical protein	0.0359	0.0563	0.148
Toxoplasma gondii	EF hand domain-containing protein	0.0199	0.0202	0.0298
Echinococcus multilocularis	geminin	0.0168	0.0131	0.002
Brugia malayi	Papain family cysteine protease containing protein	0.0202	0.0209	0.01
Trichomonas vaginalis	calcium binding protein, putative	0.0222	0.0253	0.0467
Schistosoma mansoni	ef hand domain family member A2	0.0199	0.0202	0.0092
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0266	0.0353	0.0245
Trypanosoma cruzi	cysteine protease, putative	0.0202	0.0209	0.01
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0255	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0255	0.0255
Trypanosoma cruzi	kinesin, putative	0.0891	0.1772	0.168
Plasmodium vivax	hypothetical protein, conserved	0.0202	0.0208	0.0394
Plasmodium vivax	centrin-1, putative	0.0199	0.0202	0.0369
Echinococcus granulosus	EF hand domain containing family member A2	0.0202	0.0208	0.0099
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0243	0.0301	0.0335
Echinococcus granulosus	calpain	0.125	0.2586	0.2503
Trypanosoma brucei	calpain, putative	0.0359	0.0563	0.1218
Plasmodium vivax	calpain, putative	0.125	0.2586	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0159	0.0111	0.0111
Trichomonas vaginalis	calpain, putative	0.0359	0.0563	0.148
Trypanosoma brucei	antigen, putative	0.125	0.2586	0.8034
Onchocerca volvulus		0.0266	0.0353	0.055
Trichomonas vaginalis	calmodulin, putative	0.0199	0.0202	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0359	0.0563	0.0563
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0199	0.0202	0.0549
Trichomonas vaginalis	calmodulin, putative	0.0199	0.0202	0.0298
Loa Loa (eye worm)	calpain D	0.0359	0.0563	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0111	0.0111
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0266	0.0353	0.0353
Echinococcus granulosus	cysteine protease	0.0202	0.0209	0.01
Trypanosoma brucei	calpain, putative	0.0359	0.0563	0.1218
Schistosoma mansoni	calpain-7 (C02 family)	0.125	0.2586	0.2503
Echinococcus granulosus	cathepsin l1	0.0223	0.0255	0.0146
Onchocerca volvulus		0.0266	0.0353	0.055
Schistosoma mansoni	neuronal calcium sensor	0.0199	0.0202	0.0092
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.2503
Trichomonas vaginalis	calmodulin, putative	0.0199	0.0202	0.0298
Entamoeba histolytica	cysteine proteinase 2	0.0202	0.0209	0.0592
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0243	0.0301	0.0623
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.125	0.2586	0.2503
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0359	0.0563	0.0458
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Brugia malayi	calpain family protein 1	0.3354	0.736	0.7331
Brugia malayi	calpain family protein 1	0.3354	0.736	0.7331
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Trypanosoma cruzi	centrin, putative	0.0222	0.0253	0.0144
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Entamoeba histolytica	calmodulin, putative	0.0199	0.0202	0.0549
Onchocerca volvulus		0.0199	0.0202	0.0207
Brugia malayi	calcium-binding protein	0.0199	0.0202	0.0092
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0199	0.0202	0.0092
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.2503
Onchocerca volvulus	Cathepsin L homolog	0.0266	0.0353	0.055
Leishmania major	cysteine peptidase A (CPA)	0.0266	0.0353	0.0511
Leishmania major	hypothetical protein, conserved	0.0202	0.0208	0.0022
Echinococcus multilocularis	EF hand domain containing family member A2	0.0202	0.0208	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0266	0.0353	0.0794
Brugia malayi	Cathepsin L-like precursor	0.0266	0.0353	0.0245
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4518	1	1
Toxoplasma gondii	EFHC1, putative	0.0199	0.0202	0.0298
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0243	0.0301	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0234	0.0281	0.0281
Trichomonas vaginalis	calcium binding protein, putative	0.0199	0.0202	0.0298
Echinococcus multilocularis	calpain	0.125	0.2586	0.2503
Trichomonas vaginalis	calmodulin, putative	0.0199	0.0202	0.0298
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Loa Loa (eye worm)	fibroinase	0.0266	0.0353	0.0353
Echinococcus multilocularis	calpain family protein 1, d	0.2463	0.5338	0.5285
Trypanosoma cruzi	I/6 autoantigen, putative	0.0199	0.0202	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0199	0.0202	0.0298
Schistosoma mansoni	centrin-related	0.0199	0.0202	0.0092
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.125	0.2586	0.2503
Loa Loa (eye worm)	hypothetical protein	0.2463	0.5338	0.5338
Echinococcus granulosus	calumenin	0.0202	0.0208	0.0099
Brugia malayi	programmed cell death protein 6	0.0199	0.0202	0.0092
Loa Loa (eye worm)	calpain 5	0.0891	0.1772	0.1772
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Plasmodium vivax	vivapain-3	0.0202	0.0209	0.0398
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0359	0.0563	0.0458
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0255	0.0146
Echinococcus multilocularis	programmed cell death protein	0.0222	0.0253	0.0144
Trypanosoma brucei	calpain-like protein, putative	0.125	0.2586	0.8034
Entamoeba histolytica	grainin 2	0.0222	0.0253	0.0859
Trypanosoma cruzi	cysteine proteinase, putative	0.0202	0.0209	0.01
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0359	0.0563	0.148
Onchocerca volvulus		0.0202	0.0208	0.0221
Entamoeba histolytica	cysteine proteinase, putative	0.0202	0.0209	0.0592
Trichomonas vaginalis	calmodulin, putative	0.0202	0.0208	0.0319
Brugia malayi	Cathepsin L-like precursor	0.0266	0.0353	0.0245
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trypanosoma cruzi	cysteine peptidase, putative	0.0266	0.0353	0.0245
Schistosoma mansoni	reticulocalbin	0.0202	0.0208	0.0099
Trichomonas vaginalis	calcineurin B subunit, putative	0.0199	0.0202	0.0298
Echinococcus multilocularis	calmodulin	0.0199	0.0202	0.0092
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0359	0.0563	0.0458
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0159	0.0111	0.0111
Echinococcus granulosus	cathepsin l1	0.0266	0.0353	0.0245
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0199	0.0202	0.0369
Echinococcus granulosus	cathepsin b	0.4518	1	1
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.016	0.0114	0.001
Brugia malayi	Cathepsin L-like precursor	0.0266	0.0353	0.0245
Schistosoma mansoni	hypothetical protein	0.0199	0.0202	0.0092
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.016	0.0114	0.001
Brugia malayi	Cathepsin L-like precursor	0.0266	0.0353	0.0245
Echinococcus granulosus	cathepsin L cysteine protease	0.0202	0.0209	0.01
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0266	0.0353	0.5363
Entamoeba histolytica	calcium-binding protein, putative	0.0199	0.0202	0.0549
Loa Loa (eye worm)	calpain	0.125	0.2586	0.2586
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0199	0.0202	0.0092
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1507	0.3169	1
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0359	0.0563	0.1218
Schistosoma mansoni	cathepsin F (C01 family)	0.0266	0.0353	0.0245
Trypanosoma cruzi	centrin, putative	0.0222	0.0253	0.0144
Trypanosoma brucei	cysteine peptidase, putative	0.0359	0.0563	0.1218
Schistosoma mansoni	calmodulin related calcium binding protein	0.0199	0.0202	0.0092
Entamoeba histolytica	cysteine proteinase, putative	0.0266	0.0353	0.1461
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0359	0.0563	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Trichomonas vaginalis	calpain, putative	0.0359	0.0563	0.148
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Giardia lamblia	Hypothetical protein	0.0243	0.0301	0.0623
Brugia malayi	Papain family cysteine protease containing protein	0.0202	0.0209	0.01
Schistosoma mansoni	calpain C (C02 family)	0.125	0.2586	0.2503
Trichomonas vaginalis	calcium binding proteins, putative	0.0199	0.0202	0.0298
Trichomonas vaginalis	calpain, putative	0.0359	0.0563	0.148
Schistosoma mansoni	hypothetical protein	0.0168	0.0131	0.002
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.8034
Trypanosoma brucei	Calpain-like protein 1.1	0.0359	0.0563	0.1218
Loa Loa (eye worm)	programmed cell death protein 6	0.0202	0.0208	0.0208
Trypanosoma brucei	calpain-like protein, putative	0.125	0.2586	0.8034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0266	0.0353	0.0794
Trichomonas vaginalis	conserved hypothetical protein	0.0359	0.0563	0.148
Onchocerca volvulus		0.0266	0.0353	0.055
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3354	0.736	0.7331
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Toxoplasma gondii	calmodulin CAM1	0.0202	0.0208	0.0319
Trypanosoma cruzi	cysteine peptidase, putative	0.0266	0.0353	0.0245
Schistosoma mansoni	rab	0.0199	0.0202	0.0092
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0199	0.0202	0.0092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.0209	0.0024
Trichomonas vaginalis	centrin, putative	0.0199	0.0202	0.0298
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Onchocerca volvulus		0.0266	0.0353	0.055
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0891	0.1772	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.8034
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Trypanosoma brucei	calmodulin, putative	0.0202	0.0208	0.0022
Echinococcus granulosus	cathepsin L	0.0202	0.0209	0.01
Echinococcus multilocularis	hypothetical protein	0.125	0.2586	0.2503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Schistosoma mansoni	neuronal calcium sensor	0.0199	0.0202	0.0092
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0243	0.0301	0.0623
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0359	0.0563	0.148
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Schistosoma mansoni	calpain-7 (C02 family)	0.125	0.2586	0.2503
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0359	0.0563	0.0458
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0266	0.0353	0.0245
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0255	0.0472
Trichomonas vaginalis	calmodulin, putative	0.0199	0.0202	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Brugia malayi	NAD-dependent deacetylase SIRT1	0.016	0.0114	0.0003
Trypanosoma cruzi	cysteine peptidase, putative	0.0266	0.0353	0.0245
Plasmodium vivax	vivapain-2	0.0266	0.0353	0.0981
Toxoplasma gondii	cathepsin CPL	0.0266	0.0353	0.0794
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1507	0.3169	1
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Plasmodium vivax	vivapain-2	0.0266	0.0353	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0202	0.0202
Entamoeba histolytica	calmodulin, putative	0.0199	0.0202	0.0549
Entamoeba histolytica	cysteine proteinase, putative	0.0202	0.0209	0.0592
Trypanosoma brucei	kinesin, putative	0.0891	0.1772	0.5292
Leishmania major	kinesin, putative	0.0891	0.1772	0.5292
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Entamoeba histolytica	cysteine proteinase, putative	0.0202	0.0209	0.0592
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Schistosoma mansoni	chromatin regulatory protein sir2	0.0243	0.0301	0.0193
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3553	0.7812	0.7788
Trichomonas vaginalis	calmodulin, putative	0.0199	0.0202	0.0298
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0202	0.0209	0.01
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0202	0.0208	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0359	0.0563	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0255	0.0255
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Echinococcus multilocularis	cathepsin b	0.4518	1	1
Entamoeba histolytica	protein kinase, putative	0.0891	0.1772	1
Leishmania major	calpain family cysteine protease-like protein	0.0359	0.0563	0.1218
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0243	0.0301	0.0193
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0243	0.0301	0.0193
Schistosoma mansoni	cathepsin F (C01 family)	0.0266	0.0353	0.0245
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0359	0.0563	0.148
Schistosoma mansoni	chromatin regulatory protein sir2	0.0243	0.0301	0.0193
Trypanosoma cruzi	calmodulin, putative	0.0199	0.0202	0.0092
Echinococcus granulosus	geminin	0.0168	0.0131	0.002
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0199	0.0202	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Echinococcus granulosus	calcium uptake protein 1	0.0202	0.0208	0.0099
Echinococcus multilocularis	calcium uptake protein 1	0.0202	0.0208	0.0099
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0199	0.0202	0.0092
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0243	0.0301	0.0193
Trypanosoma cruzi	conserved protein	0.0359	0.0563	0.0458
Onchocerca volvulus		0.0199	0.0202	0.0207
Onchocerca volvulus		0.0266	0.0353	0.055
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Brugia malayi	EF hand family protein	0.0199	0.0202	0.0092
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0199	0.0202	0.0092
Schistosoma mansoni	chromatin regulatory protein sir2	0.016	0.0114	0.0003
Onchocerca volvulus		0.0223	0.0255	0.0327
Leishmania major	silent information regulator 2, putative	0.0243	0.0301	0.0335
Echinococcus granulosus	neurocalcin	0.0199	0.0202	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0111	0.0111
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4518	1	1
Loa Loa (eye worm)	calmodulin-like protein	0.0199	0.0202	0.0202
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0266	0.0353	0.0245
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0243	0.0301	0.0193
Trichomonas vaginalis	calcineurin B subunit, putative	0.0202	0.0208	0.0319
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0202	0.0208	0.0099
Entamoeba histolytica	hypothetical protein, conserved	0.0202	0.0208	0.0588
Loa Loa (eye worm)	cathepsin B	0.1507	0.3169	0.3169
Schistosoma mansoni	chromatin regulatory protein sir2	0.0243	0.0301	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0255	0.0255
Plasmodium vivax	vivapain-1	0.0202	0.0209	0.0398
Loa Loa (eye worm)	cysteine protease	0.0266	0.0353	0.0353
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4518	1	1
Brugia malayi	Cathepsin L-like precursor	0.0266	0.0353	0.0245
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Toxoplasma gondii	calcium-dependent protein kinase	0.0202	0.0208	0.0319
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.2503
Echinococcus granulosus	calpain A	0.3556	0.7819	0.7794
Schistosoma mansoni	Mername-AA248 (C02 family)	0.125	0.2586	0.2503
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0223	0.0255	0.0146
Toxoplasma gondii	cathepsin B	0.1507	0.3169	1
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Schistosoma mansoni	calmodulin	0.0199	0.0202	0.0092
Schistosoma mansoni	reticulocalbin	0.0199	0.0202	0.0092
Trypanosoma brucei	centrin-3	0.0222	0.0253	0.0174
Schistosoma mansoni	cathepsin F (C01 family)	0.0223	0.0255	0.0146
Echinococcus multilocularis	programmed cell death protein	0.0222	0.0253	0.0144
Trypanosoma cruzi	centrin-3	0.0222	0.0253	0.0144
Entamoeba histolytica	cysteine protease, putative	0.0266	0.0353	0.1461
Trypanosoma brucei	calpain-like protein, putative	0.125	0.2586	0.8034
Toxoplasma gondii	centrin, putative	0.0199	0.0202	0.0298
Trichomonas vaginalis	calmodulin-2, putative	0.0199	0.0202	0.0298
Trypanosoma brucei	caltractin, putative	0.0222	0.0253	0.0174
Loa Loa (eye worm)	calpain family protein 1	0.3354	0.736	0.736
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0199	0.0202	0.0092
Brugia malayi	calpain D	0.0359	0.0563	0.0458
Echinococcus granulosus	chromatin regulatory protein sir2	0.0243	0.0301	0.0193
Echinococcus multilocularis	EF hand domain containing family member A2	0.0199	0.0202	0.0092
Brugia malayi	Papain family cysteine protease containing protein	0.0266	0.0353	0.0245
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.2503
Trypanosoma brucei	hypothetical protein	0.0359	0.0563	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0111	0.0111
Echinococcus multilocularis	cathepsin b	0.4518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.0209	0.0322
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0359	0.0563	0.1218
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.016	0.0114	0.001
Brugia malayi	calpain 7	0.125	0.2586	0.2503
Entamoeba histolytica	cysteine proteinase 1, putative	0.0202	0.0209	0.0592
Brugia malayi	EF hand family protein	0.0202	0.0208	0.0099
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0202	0.0209	0.2174
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Schistosoma mansoni	calpain (C02 family)	0.125	0.2586	0.2503
Onchocerca volvulus		0.2104	0.4524	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Loa Loa (eye worm)	hypothetical protein	0.2996	0.6547	0.6547
Trypanosoma cruzi	cysteine proteinase, putative	0.0202	0.0209	0.01
Schistosoma mansoni	hypothetical protein	0.0359	0.0563	0.0458
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.125	0.2586	0.2503
Trypanosoma cruzi	cysteine peptidase, putative	0.0266	0.0353	0.0245
Echinococcus multilocularis	calpain A	0.3556	0.7819	0.7794
Schistosoma mansoni	hypothetical protein	0.0168	0.0131	0.002
Brugia malayi	hypothetical protein	0.0234	0.0281	0.0173
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0223	0.0255	0.0146
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.016	0.0114	0.0003
Echinococcus granulosus	cathepsin b	0.4518	1	1
Trypanosoma cruzi	calmodulin, putative	0.0199	0.0202	0.0092
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0359	0.0563	0.0458
Brugia malayi	Calmodulin-like protein	0.0199	0.0202	0.0092
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0202	0.0209	0.01
Echinococcus multilocularis	calpain 5	0.125	0.2586	0.2503
Toxoplasma gondii	centrin	0.0199	0.0202	0.0298
Trypanosoma cruzi	caltractin, putative	0.0199	0.0202	0.0092
Onchocerca volvulus		0.0266	0.0353	0.055
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0199	0.0202	0.0092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Echinococcus granulosus	calpain A	0.125	0.2586	0.2503
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.125	0.2586	0.2503
Onchocerca volvulus	Cathepsin F homolog	0.0266	0.0353	0.055
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.0255	0.0869
Plasmodium falciparum	centrin-1	0.0199	0.0202	0.2015
Giardia lamblia	Cathepsin B precursor	0.1507	0.3169	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0111	0.0111
Entamoeba histolytica	cysteine proteinase, putative	0.0266	0.0353	0.1461
Loa Loa (eye worm)	hypothetical protein	0.3354	0.736	0.736
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0359	0.0563	0.1218
Trypanosoma cruzi	kinesin, putative	0.0891	0.1772	0.168
Giardia lamblia	Cathepsin B precursor	0.1507	0.3169	1
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0359	0.0563	0.148
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0266	0.0353	0.5363
Plasmodium falciparum	calpain	0.0359	0.0563	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trichomonas vaginalis	calcium binding protein, putative	0.0199	0.0202	0.0298
Trypanosoma cruzi	I/6 autoantigen, putative	0.0199	0.0202	0.0092
Schistosoma mansoni	centrin	0.0199	0.0202	0.0092
Brugia malayi	Cathepsin L-like precursor	0.0266	0.0353	0.0245
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0243	0.0301	0.0193
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0359	0.0563	0.0458
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.3553	0.7812	0.7788
Echinococcus multilocularis	cathepsin L cysteine protease	0.0266	0.0353	0.0245
Echinococcus multilocularis	cysteine protease	0.0266	0.0353	0.0245
Echinococcus multilocularis	calpain 7 (C02 family)	0.125	0.2586	0.2503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Leishmania major	calpain protease-like protein	0.0359	0.0563	0.1218
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0359	0.0563	0.0458
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.0281	0.0173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.125	0.2586	0.8034
Echinococcus multilocularis	cysteine protease	0.0266	0.0353	0.0245
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0202	0.0209	0.01
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4518	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0255	0.0472
Echinococcus granulosus	EF hand domain containing family member A2	0.0199	0.0202	0.0092
Echinococcus granulosus	neuronal calcium sensor	0.0199	0.0202	0.0092
Trypanosoma cruzi	cruzipain precursor, putative	0.0266	0.0353	0.0245
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0243	0.0301	0.1147
Echinococcus granulosus	calpain 7 C02 family	0.125	0.2586	0.2503
Trichomonas vaginalis	centrin, putative	0.0199	0.0202	0.0298
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.125	0.2586	0.2503
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0159	0.0111	0.0111
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0202	0.0209	0.01
Plasmodium vivax	unspecified product	0.0202	0.0209	0.0398
Echinococcus multilocularis	calumenin	0.0202	0.0208	0.0099
Giardia lamblia	Cathepsin B precursor	0.1507	0.3169	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0266	0.0353	0.0794
Echinococcus multilocularis	cathepsin L cysteine protease	0.0266	0.0353	0.0245
Schistosoma mansoni	mitochondrial solute carrier	0.0199	0.0202	0.0092
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0359	0.0563	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0266	0.0353	0.5363
Trypanosoma brucei	calpain-like protein, putative	0.125	0.2586	0.8034
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.016	0.0114	0.001
Trichomonas vaginalis	myosin light chain 1, putative	0.0199	0.0202	0.0298
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0199	0.0202	0.0092
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0199	0.0202	0.0549
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.0209	0.0322
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1507	0.3169	0.3093
Schistosoma mansoni	calmodulin	0.0199	0.0202	0.0092
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0359	0.0563	0.1218
Entamoeba histolytica	cysteine protease, putative	0.0202	0.0209	0.0592
Trichomonas vaginalis	conserved hypothetical protein	0.0199	0.0202	0.0298
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0359	0.0563	0.0458
Trichomonas vaginalis	calcium binding protein, putative	0.0199	0.0202	0.0298
Echinococcus granulosus	calmodulin	0.0199	0.0202	0.0092
Echinococcus granulosus	calbindin 32	0.0202	0.0208	0.0099
Echinococcus multilocularis	calbindin 32	0.0202	0.0208	0.0099
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0199	0.0202	0.0298
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.1218
Trypanosoma brucei	Calpain-like protein 1.2	0.0359	0.0563	0.1218
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.0281	0.0173
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0199	0.0202	0.0092
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0199	0.0202	0.0092
Loa Loa (eye worm)	transcriptional regulator	0.0243	0.0301	0.0301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.0209	0.0024
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.016	0.0114	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0266	0.0353	0.0511
Entamoeba histolytica	calpain family cysteine protease, putative	0.0359	0.0563	0.2724
Loa Loa (eye worm)	ctsf protein	0.0266	0.0353	0.0353
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0359	0.0563	0.0458
Brugia malayi	cathepsin L-like precursor	0.0223	0.0255	0.0146
Entamoeba histolytica	calcium binding family protein	0.0199	0.0202	0.0549
Brugia malayi	calpain 5	0.0359	0.0563	0.0458
Schistosoma mansoni	neuronal calcium sensor	0.0199	0.0202	0.0092
Schistosoma mansoni	hypothetical protein	0.0199	0.0202	0.0092
Echinococcus granulosus	programmed cell death protein	0.0222	0.0253	0.0144
Schistosoma mansoni	calpain-2 (C02 family)	0.0359	0.0563	0.0458
Trichomonas vaginalis	calmodulin, putative	0.0199	0.0202	0.0298
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0266	0.0353	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0266	0.0353	0.0353
Leishmania major	cathepsin L-like protease	0.0266	0.0353	0.0511
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0359	0.0563	0.148
Leishmania major	hypothetical protein, conserved	0.0359	0.0563	0.1218

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3 nM	Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand	ChEMBL.	15456246
IC50 (binding)	= 3 nM	Inhibitory concentration against human ER beta expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand	ChEMBL.	15456246
IC50 (binding)	= 3 nM	Binding affinity to ERbeta	ChEMBL.	17459530
IC50 (binding)	= 98 nM	Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand	ChEMBL.	15456246
IC50 (binding)	= 98 nM	Inhibitory concentration against human ER alpha expressed in E. coli was determined using [3H]-17-beta-estradiol as radio ligand	ChEMBL.	15456246
Selectivity (binding)	= 39	Selectivity fold for estrogen receptor beta over estrogen receptor alpha	ChEMBL.	15456246
Selectivity (binding)	= 39	Selectivity fold for estrogen receptor beta over estrogen receptor alpha	ChEMBL.	15456246

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL189356

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 328996