Detailed information for compound 332469

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 218.252 | Formula: C12H14N2O2
  • H donors: 1 H acceptors: 2 LogP: 1.8 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc2c(c1)CC1CC2CNC1
  • InChi: 1S/C12H14N2O2/c15-14(16)11-1-2-12-9(5-11)3-8-4-10(12)7-13-6-8/h1-2,5,8,10,13H,3-4,6-7H2
  • InChiKey: NTFKOQBZSNCLLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, nicotinic, alpha 4 (neuronal) Starlite/ChEMBL References
Homo sapiens cholinergic receptor, nicotinic, beta 4 (neuronal) References
Homo sapiens cholinergic receptor, nicotinic, beta 2 (neuronal) References
Homo sapiens cholinergic receptor, nicotinic, alpha 3 (neuronal) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Onchocerca volvulus Putative nachr subunit Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128160 All targets in OG5_128160
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cation transporter family protein cholinergic receptor, nicotinic, beta 4 (neuronal) 498 aa 508 aa 31.1 %
Brugia malayi Cation transporter family protein cholinergic receptor, nicotinic, beta 2 (neuronal) 502 aa 482 aa 32.4 %
Brugia malayi Cation transporter family protein cholinergic receptor, nicotinic, alpha 3 (neuronal) 505 aa 486 aa 34.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calumenin 0.0071 0.0202 0.0186
Brugia malayi hypothetical protein 0.0028 0.0019 0.0002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0202 0.0188
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0052 0.0124 0.0109
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Leishmania major calpain family cysteine protease-like protein 0.014 0.05 0.14
Schistosoma mansoni immunophilin 0.038 0.1526 0.1512
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0231 0.0888 0.0888
Brugia malayi calpain family protein 1 0.1238 0.5191 0.5183
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.037 0.0322
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0083 0.0256 0.024
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Schistosoma mansoni hypothetical protein 0.0071 0.0202 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.1856
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0083 0.0256 0.1461
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0023
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0467 0.1896 0.1856
Echinococcus multilocularis chromobox protein 1 0.0072 0.0209 0.0209
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.5735
Echinococcus multilocularis programmed cell death protein 0.0132 0.0465 0.0465
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0052 0.0124 0.0232
Giardia lamblia Cathepsin B precursor 0.0083 0.0256 0.058
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.014 0.05 0.147
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0103 0.0103
Plasmodium falciparum cysteine proteinase falcipain 1 0.0106 0.0354 0.2062
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.006 0.0157 0.0141
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.5735
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0049 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0052 0.0124 0.5
Plasmodium falciparum serine repeat antigen 4 0.0083 0.0256 0.14
Schistosoma mansoni hypothetical protein 0.0041 0.0073 0.0056
Schistosoma mansoni myosin light chain 0.0061 0.0163 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0083 0.0256 0.0718
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0023
Giardia lamblia Programmed cell death protein-like protein 0.0061 0.0163 0.0288
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0071 0.0202 0.0553
Giardia lamblia Hypothetical protein 0.0083 0.0256 0.058
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.1196
Loa Loa (eye worm) myosin Light Chain family member 0.0061 0.0163 0.0148
Loa Loa (eye worm) calpain 5 0.0327 0.1296 0.1283
Onchocerca volvulus 0.011 0.037 0.1111
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0702 0.2902 1
Echinococcus multilocularis calmodulin 0.0071 0.0202 0.0202
Brugia malayi programmed cell death protein 6 0.0071 0.0202 0.0186
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0052 0.0124 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0017 0.0002
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.038 0.1526 0.1484
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0083 0.0256 0.112
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0028 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.1196
Giardia lamblia Cysteine protease 0.0083 0.0256 0.058
Entamoeba histolytica grainin 2 0.0061 0.0163 0.0834
Mycobacterium tuberculosis Conserved protein 0.011 0.037 0.0886
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Loa Loa (eye worm) beta-lactamase 0.011 0.037 0.0356
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0079 0.0063
Onchocerca volvulus 0.0052 0.0124 0.0337
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.038 0.1526 0.1512
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0049 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0214 0.0214
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0028 0.0019 0.0002
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Entamoeba histolytica cysteine protease, putative 0.0083 0.0256 0.1461
Trypanosoma brucei centrin-3 0.0132 0.0465 0.1085
Giardia lamblia Cathepsin B precursor 0.0083 0.0256 0.058
Echinococcus granulosus calpain 7 C02 family 0.0467 0.1896 0.1882
Loa Loa (eye worm) hypothetical protein 0.0071 0.0202 0.0188
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0073 0.0178
Plasmodium falciparum serine repeat antigen 8 0.0083 0.0256 0.14
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0052 0.0124 0.0107
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0126 0.0126
Trypanosoma brucei I/6 autoantigen 0.0071 0.0202 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Loa Loa (eye worm) hypothetical protein 0.011 0.037 0.0356
Loa Loa (eye worm) hypothetical protein 0.0231 0.0888 0.0875
Schistosoma mansoni cathepsin C 0.0083 0.0256 0.024
Echinococcus multilocularis Myosin regulatory light chain 0.0061 0.0163 0.0163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0039 0.0023
Toxoplasma gondii centrin 0.0071 0.0202 0.0475
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.038 0.1526 0.4457
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.037 0.0354
Trypanosoma brucei calmodulin, putative 0.0071 0.0202 0.025
Plasmodium falciparum centrin-4 0.0061 0.0163 0.0768
Loa Loa (eye worm) hypothetical protein 0.0051 0.012 0.0106
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0071 0.0202 0.0154
Loa Loa (eye worm) GABA receptor subunit 0.0032 0.0038 0.0024
Schistosoma mansoni Mername-AA248 (C02 family) 0.0467 0.1896 0.1882
Echinococcus multilocularis lamin dm0 0.0027 0.0017 0.0017
Trichomonas vaginalis calcium binding protein, putative 0.0071 0.0202 0.0553
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.038 0.1526 0.1512
Toxoplasma gondii cathepsin B 0.0788 0.3269 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.037 0.037
Onchocerca volvulus 0.0086 0.027 0.0796
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2363 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Schistosoma mansoni neuronal calcium sensor 0.0071 0.0202 0.0186
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0231 0.0888 0.0873
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0052 0.0124 0.0166
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.037 0.0322
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0126 0.0126
Giardia lamblia Cathepsin L-like protease 0.0083 0.0256 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0399 0.116
Brugia malayi calpain 5 0.0327 0.1296 0.1281
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0498 0.0482
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0157 0.0141
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0073 0.0156
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0071 0.0204 0.0256
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0083 0.0256 0.024
Echinococcus multilocularis protein patched 0.0042 0.0079 0.0079
Entamoeba histolytica cysteine proteinase 1, putative 0.0106 0.0354 0.2119
Trypanosoma cruzi cysteine proteinase, putative 0.0106 0.0354 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0256 0.0718
Trichomonas vaginalis centrin, putative 0.0061 0.0163 0.0431
Brugia malayi Cathepsin L-like precursor 0.014 0.0497 0.0481
Leishmania major calpain protease-like protein 0.014 0.05 0.14
Toxoplasma gondii calmodulin CAM1 0.0071 0.0202 0.0475
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.006 0.0157 0.0141
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Schistosoma mansoni centrin 0.0071 0.0202 0.0186
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Schistosoma mansoni nAChR subunit 0.006 0.0157 0.0141
Trichomonas vaginalis kakapo, putative 0.0061 0.0163 0.0431
Schistosoma mansoni hypothetical protein 0.0052 0.0124 0.0107
Echinococcus multilocularis lamin 0.0027 0.0017 0.0017
Echinococcus multilocularis expressed conserved protein 0.0092 0.0293 0.0293
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0209 0.0574
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0039 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.037 0.1069
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0083 0.0256 0.112
Echinococcus multilocularis programmed cell death protein 6 0.0061 0.0163 0.0163
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0039 0.0023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0256 0.024
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1309 0.5494 0.5486
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.037 0.0886
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0124 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0399 0.116
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.3269 0.3269
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0467 0.1896 0.1856
Giardia lamblia Encystation-specific protease 0.0083 0.0256 0.058
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0019 0.0002
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0083 0.0256 0.024
Schistosoma mansoni neurotransmitter gated ion channel 0.0032 0.0038 0.0022
Mycobacterium tuberculosis Conserved protein 0.011 0.037 0.0886
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0354 0.0338
Echinococcus multilocularis cathepsin b 0.2363 1 1
Schistosoma mansoni acetylcholine receptor-related 0.0028 0.0019 0.0002
Loa Loa (eye worm) ACC-1 protein 0.006 0.0157 0.0143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0788 0.3269 0.3258
Leishmania major i/6 autoantigen-like protein 0.0071 0.0202 0.0475
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0126 0.0077
Echinococcus multilocularis protein dispatched 1 0.0048 0.0105 0.0105
Brugia malayi MAP kinase sur-1 0.0053 0.0126 0.0109
Loa Loa (eye worm) integrin beta-2 0.032 0.1269 0.1256
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.014 0.05 0.0453
Echinococcus granulosus calbindin 32 0.0071 0.0202 0.0186
Trypanosoma brucei cysteine peptidase, putative 0.014 0.05 0.1196
Brugia malayi hypothetical protein 0.0049 0.0108 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0202 0.0829
Giardia lamblia Cathepsin L precursor 0.0083 0.0256 0.058
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0023
Trypanosoma cruzi calmodulin, putative 0.0071 0.0202 0.0154
Echinococcus granulosus EF hand domain containing family member A2 0.0071 0.0202 0.0186
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0354 0.0338
Echinococcus multilocularis cathepsin L cysteine protease 0.014 0.0497 0.0497
Schistosoma mansoni neuronal calcium sensor 0.0071 0.0202 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Echinococcus granulosus glycine receptor subunit beta 0.006 0.0157 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0256 0.0718
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Leishmania major cysteine peptidase A (CPA) 0.014 0.0497 0.1391
Loa Loa (eye worm) hypothetical protein 0.0041 0.0073 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Leishmania major hypothetical protein, conserved 0.0071 0.0202 0.0475
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.006 0.0157 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.037 0.1069
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0214 0.0197
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Trichomonas vaginalis caltractin, putative 0.0061 0.0163 0.0431
Schistosoma mansoni calpain-2 (C02 family) 0.014 0.05 0.0484
Brugia malayi RNA binding protein 0.0063 0.0169 0.0153
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Brugia malayi N-terminal motif family protein 0.0184 0.0688 0.0672
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.006 0.0157 0.0143
Entamoeba histolytica calmodulin, putative 0.0071 0.0202 0.11
Loa Loa (eye worm) hypothetical protein 0.0061 0.0163 0.0148
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0079 0.0079
Giardia lamblia Hypothetical protein 0.0052 0.0124 0.0166
Giardia lamblia Cathepsin L precursor 0.0083 0.0256 0.058
Schistosoma mansoni nAChR subunit 0.006 0.0157 0.0141
Onchocerca volvulus 0.014 0.0497 0.1512
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0071 0.0202 0.11
Leishmania major protein kinase, putative 0.0071 0.0204 0.0482
Onchocerca volvulus 0.0071 0.0202 0.0584
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0256 0.024
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.038 0.1526 0.7996
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.006 0.0157 0.0141
Loa Loa (eye worm) hypothetical protein 0.0117 0.0399 0.0385
Loa Loa (eye worm) cathepsin B 0.0788 0.3269 0.326
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0124 0.0572
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0086 0.0195
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Leishmania major peptidylprolyl isomerase-like protein 0.038 0.1526 0.4586
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Onchocerca volvulus 0.0028 0.0019 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0083 0.0256 0.0718
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0788 0.3269 0.3236
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.1856
Entamoeba histolytica cysteine protease, putative 0.0083 0.0256 0.1461
Trypanosoma cruzi kinesin, putative 0.0327 0.1296 0.1253
Trypanosoma brucei Calpain-like protein 1.1 0.014 0.05 0.1196
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.014 0.05 0.0453
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0083 0.0256 0.112
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Echinococcus multilocularis cathepsin b 0.2363 1 1
Onchocerca volvulus Putative nachr subunit 0.0231 0.0888 0.2741
Leishmania major calmodulin, putative 0.0071 0.0202 0.0475
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.0688 0.2111
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0169 0.0153
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Echinococcus granulosus EF HAND 1 calcium binding site 0.0071 0.0202 0.0186
Leishmania major centrin, putative,caltractin, putative 0.0071 0.0202 0.0475
Schistosoma mansoni hypothetical protein 0.0035 0.0049 0.0032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0103 0.0086
Echinococcus granulosus neurocalcin 0.0071 0.0202 0.0186
Trichomonas vaginalis centrin, putative 0.0071 0.0202 0.0553
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0231 0.0888 0.0875
Echinococcus multilocularis chromobox protein 1 0.0072 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0788 0.3269 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0467 0.1896 0.1856
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0086 0.0114
Leishmania major hypothetical protein, conserved 0.0071 0.0202 0.0475
Leishmania major calmodulin-like protein 0.0071 0.0202 0.0475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Onchocerca volvulus Cathepsin L homolog 0.0083 0.0256 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0124 0.0311
Schistosoma mansoni calmodulin related calcium binding protein 0.0071 0.0202 0.0186
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0086 0.0219
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Echinococcus multilocularis calmodulin 0.0071 0.0202 0.0202
Toxoplasma gondii centrin, putative 0.0071 0.0202 0.0475
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.014 0.05 0.0453
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1309 0.5494 0.5486
Echinococcus multilocularis glycine receptor subunit alpha 1 0.006 0.0157 0.0157
Loa Loa (eye worm) FKBP5 protein 0.038 0.1526 0.1514
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0083 0.0256 0.112
Loa Loa (eye worm) hypothetical protein 0.011 0.037 0.0356
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.006 0.0157 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0354 0.2119
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0169 0.0153
Trichomonas vaginalis fk506 binding protein, putative 0.0052 0.0124 0.0311
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.006 0.0157 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0103 0.0086
Leishmania major programmed cell death 6 protein-like protein 0.0071 0.0202 0.0475
Schistosoma mansoni integrin beta subunit 0.0189 0.0706 0.069
Echinococcus granulosus glycine receptor subunit alpha 1 0.006 0.0157 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0354 0.102
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0032 0.0038 0.0022
Loa Loa (eye worm) hypothetical protein 0.0083 0.0256 0.0242
Echinococcus granulosus integrin beta 2 0.0237 0.0914 0.0899
Echinococcus multilocularis glycine receptor subunit alpha 1 0.006 0.0157 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Trypanosoma brucei hypothetical protein 0.014 0.05 0.1196
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0467 0.1896 0.1856
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0256 0.0718
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Brugia malayi Kelch motif family protein 0.0049 0.0108 0.0091
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.006 0.0157 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0169 0.0153
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0052 0.0124 0.0166
Echinococcus multilocularis calbindin 32 0.0071 0.0202 0.0202
Onchocerca volvulus 0.014 0.0497 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0256 0.0718
Echinococcus multilocularis centrin 2 0.0071 0.0202 0.0202
Echinococcus multilocularis calpain 7 (C02 family) 0.0467 0.1896 0.1896
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Plasmodium vivax vivapain-1 0.0106 0.0354 0.1649
Brugia malayi MH2 domain containing protein 0.0122 0.0421 0.0405
Onchocerca volvulus 0.0032 0.0036 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.037 0.0354
Onchocerca volvulus 0.014 0.0497 0.1512
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0052 0.0124 0.0109
Trypanosoma brucei Component of motile flagella 41 0.0071 0.0202 0.025
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.0497 0.045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0065
Schistosoma mansoni cathepsin B (C01 family) 0.0083 0.0256 0.024
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.006 0.0157 0.0141
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0038 0.0022
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2363 1 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0071 0.0202 0.0154
Leishmania major centrin, putative 0.0071 0.0202 0.0475
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0124 0.0505
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.038 0.1526 0.455
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.006 0.0157 0.0141
Onchocerca volvulus Cathepsin L homolog 0.014 0.0497 0.1512
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.037 0.1755
Entamoeba histolytica grainin, putative 0.0071 0.0202 0.11
Echinococcus granulosus centrin 2 0.0071 0.0202 0.0186
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Loa Loa (eye worm) ACC-1 protein 0.006 0.0157 0.0143
Trypanosoma cruzi I/6 autoantigen, putative 0.0071 0.0202 0.0154
Brugia malayi Cathepsin L-like cysteine proteinase 0.0117 0.0399 0.0383
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0169 0.0153
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0467 0.1896 0.1856
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0052 0.0124 0.0107
Trypanosoma cruzi centrin, putative 0.0132 0.0465 0.0418
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0231 0.0888 0.0873
Onchocerca volvulus 0.0061 0.0163 0.0459
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0083 0.0256 0.024
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0086 0.0196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0103 0.0088
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.5735
Trypanosoma brucei mitochondrial calcium uptake 1 0.0071 0.0202 0.025
Echinococcus multilocularis EF hand domain containing family member A2 0.0071 0.0202 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.014 0.0497 0.1462
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0256 0.058
Loa Loa (eye worm) LGC-31 protein 0.006 0.0157 0.0143
Echinococcus multilocularis hypothetical protein 0.0467 0.1896 0.1896
Brugia malayi calpain D 0.014 0.05 0.0484
Loa Loa (eye worm) hypothetical protein 0.01 0.0326 0.0312
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0231 0.0888 0.0873
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0169 0.0155
Echinococcus multilocularis glycine receptor subunit beta 0.006 0.0157 0.0157
Loa Loa (eye worm) calpain D 0.014 0.05 0.0486
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0202 0.025
Echinococcus granulosus calpain A 0.0467 0.1896 0.1882
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.038 0.1526 0.1512
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0318 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0103 0.0086
Trypanosoma brucei Calpain-like protein CALP1.3 0.014 0.05 0.1196
Echinococcus multilocularis fk506 binding protein 0.038 0.1526 0.1526
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0214 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.1196
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0052 0.0124 0.0107
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.037 0.0356
Echinococcus multilocularis neuronal calcium sensor 0.0071 0.0202 0.0202
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.037 0.1069
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.006 0.0157 0.0141
Trichomonas vaginalis calcineurin B subunit, putative 0.0071 0.0202 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0163 0.0431
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Leishmania major fk506-binding protein 1-like protein 0.038 0.1526 0.4586
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0256 0.0718
Echinococcus granulosus cathepsin L 0.0106 0.0354 0.0338
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.014 0.05 0.147
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.014 0.0497 0.1462
Brugia malayi Cathepsin L-like precursor 0.014 0.0497 0.0481
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0083 0.0256 0.1461
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.006 0.0157 0.0157
Brugia malayi Calmodulin-like protein 0.0071 0.0202 0.0186
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0052 0.0124 0.0232
Trypanosoma brucei hypothetical protein, conserved 0.011 0.037 0.0782
Loa Loa (eye worm) hypothetical protein 0.0117 0.0399 0.0385
Toxoplasma gondii calmodulin CAM2 0.0061 0.0163 0.0352
Leishmania major centrin, putative 0.0071 0.0202 0.0475
Trichomonas vaginalis calmodulin, putative 0.0061 0.0163 0.0431
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.006 0.0157 0.0141
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0106 0.0354 0.0731
Echinococcus multilocularis calpain family protein 1, d 0.0911 0.3795 0.3795
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.006 0.0157 0.0141
Trypanosoma cruzi cruzipain precursor, putative 0.014 0.0497 0.045
Schistosoma mansoni calpain-7 (C02 family) 0.0467 0.1896 0.1882
Entamoeba histolytica cysteine proteinase, putative 0.014 0.0497 0.3083
Brugia malayi Cation transporter family protein 0.006 0.0157 0.0141
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2363 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0354 0.2119
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.5634
Onchocerca volvulus 0.014 0.0497 0.1512
Toxoplasma gondii centrin family protein 0.0061 0.0163 0.0352
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0028 0.0019 0.0002
Echinococcus granulosus cathepsin L 0.0083 0.0256 0.024
Brugia malayi Cathepsin L-like precursor 0.014 0.0497 0.0481
Loa Loa (eye worm) fibroinase 0.014 0.0497 0.0483
Trypanosoma brucei calmodulin, putative 0.0071 0.0202 0.025
Loa Loa (eye worm) hypothetical protein 0.1098 0.4591 0.4584
Loa Loa (eye worm) hypothetical protein 0.014 0.0497 0.0483
Loa Loa (eye worm) hypothetical protein 0.0184 0.0688 0.0674
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0126 0.0239
Toxoplasma gondii EF hand domain-containing protein 0.0061 0.0163 0.0352
Plasmodium vivax calpain, putative 0.0467 0.1896 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0028 0.0019 0.0002
Echinococcus granulosus cathepsin b 0.2363 1 1
Trichomonas vaginalis fk506-binding protein, putative 0.038 0.1526 0.463
Schistosoma mansoni nAChR subunit 0.0028 0.0019 0.0002
Trichomonas vaginalis calcium binding protein, putative 0.0071 0.0202 0.0553
Plasmodium vivax serine-repeat antigen (SERA) 0.0083 0.0256 0.112
Trypanosoma brucei calpain-like protein, putative 0.0467 0.1896 0.5634
Loa Loa (eye worm) hypothetical protein 0.014 0.05 0.0486
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.006 0.0157 0.0143
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0106 0.0354 0.0338
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.006 0.0157 0.0141
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.037 0.1069
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.038 0.1526 0.1512
Toxoplasma gondii cathepsin CPC1 0.0083 0.0256 0.0642
Toxoplasma gondii troponin c, isotype gamma, putative 0.0071 0.0202 0.0475
Trypanosoma brucei calpain, putative 0.014 0.05 0.1196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Trichomonas vaginalis caltractin, putative 0.0061 0.0163 0.0431
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0157 0.0141
Brugia malayi Papain family cysteine protease containing protein 0.014 0.0497 0.0481
Echinococcus multilocularis EF hand domain containing family member A2 0.0071 0.0202 0.0202
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0071 0.0204 0.0156
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0256 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0083 0.0256 0.0718
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0052 0.0124 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0083 0.0256 0.0718
Trichomonas vaginalis calpain, putative 0.014 0.05 0.147
Schistosoma mansoni chromobox protein 0.0072 0.0209 0.0193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0341 0.0325
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0106 0.0354 0.0338
Leishmania major hypothetical protein, conserved 0.014 0.05 0.14
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0126 0.0318
Entamoeba histolytica cysteine protease, putative 0.0083 0.0256 0.1461
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Plasmodium falciparum serine repeat antigen 7 0.0083 0.0256 0.14
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Echinococcus multilocularis calcyphosin protein 0.0061 0.0163 0.0163
Onchocerca volvulus 0.0117 0.0399 0.1204
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Toxoplasma gondii calmodulin, putative 0.0061 0.0163 0.0352
Giardia lamblia Cathepsin L precursor 0.0083 0.0256 0.058
Onchocerca volvulus 0.0052 0.0124 0.0337
Loa Loa (eye worm) hypothetical protein 0.0071 0.0201 0.0187
Echinococcus granulosus calcyphosin protein 0.0061 0.0163 0.0146
Trypanosoma brucei kinesin, putative 0.0327 0.1296 0.3726
Brugia malayi hypothetical protein 0.0028 0.0019 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0079 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.014 0.05 0.147
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Echinococcus multilocularis calpain A 0.1309 0.5494 0.5494
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0083 0.0256 0.058
Loa Loa (eye worm) acetyltransferase 0.0148 0.0532 0.0519
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Giardia lamblia Cathepsin L precursor 0.0083 0.0256 0.058
Trypanosoma brucei calpain-like protein, putative 0.0467 0.1896 0.5634
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0126 0.0239
Echinococcus granulosus calmodulin 0.0071 0.0202 0.0186
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0086 0.0195
Echinococcus granulosus programmed cell death protein 0.0132 0.0465 0.0449
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0209 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0169 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0103 0.0086
Loa Loa (eye worm) hypothetical protein 0.0083 0.0256 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Trichomonas vaginalis calcineurin B subunit, putative 0.0071 0.0202 0.0553
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.0497 0.045
Echinococcus granulosus nAChR subunit 0.006 0.0157 0.0141
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0039 0.0039
Giardia lamblia Cathepsin B precursor 0.0788 0.3269 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Echinococcus granulosus Calcium binding protein 0.0061 0.0163 0.0146
Brugia malayi Cathepsin L-like precursor 0.014 0.0497 0.0481
Giardia lamblia Cathepsin B precursor 0.0083 0.0256 0.058
Loa Loa (eye worm) hypothetical protein 0.0049 0.0108 0.0093
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.014 0.05 0.1196
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.011 0.037 0.0356
Plasmodium falciparum serine repeat antigen 6 0.0083 0.0256 0.14
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Giardia lamblia Hypothetical protein 0.0083 0.0256 0.058
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0231 0.0888 0.0888
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0209 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0061 0.0163 0.0459
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0039 0.0023
Onchocerca volvulus 0.014 0.0497 0.1512
Giardia lamblia Cathepsin L precursor 0.0083 0.0256 0.058
Brugia malayi cathepsin L-like cysteine proteinase 0.0083 0.0256 0.024
Onchocerca volvulus 0.0083 0.0256 0.0752
Onchocerca volvulus 0.011 0.037 0.1111
Schistosoma mansoni nAChR subunit 0.006 0.0157 0.0141
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0328 0.1302 0.1288
Echinococcus granulosus cysteine protease 0.0106 0.0354 0.0338
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0515 0.0499
Onchocerca volvulus 0.014 0.0497 0.1512
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Onchocerca volvulus 0.011 0.037 0.1111
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.014 0.05 0.14
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0202 0.0553
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0126 0.0112
Entamoeba histolytica calpain family cysteine protease, putative 0.014 0.05 0.3102
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0086 0.0069
Brugia malayi Cathepsin L-like precursor 0.0117 0.0399 0.0383
Brugia malayi beta-lactamase family protein 0.011 0.037 0.0354
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0126 0.0318
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.037 0.0886
Trichomonas vaginalis esterase, putative 0.011 0.037 0.1069
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0028 0.0019 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.038 0.1526 0.463
Schistosoma mansoni calpain (C02 family) 0.0467 0.1896 0.1882
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0141 0.0502 0.1203
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0071 0.0202 0.0186
Trichomonas vaginalis fk506-binding protein, putative 0.0052 0.0124 0.0311
Toxoplasma gondii EF hand domain-containing protein 0.0071 0.0202 0.0475
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.007 0.0214
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0052 0.0124 0.0075
Onchocerca volvulus 0.0071 0.0202 0.0584
Trypanosoma cruzi kinesin, putative 0.0327 0.1296 0.1253
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.038 0.1526 0.463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0256 0.0718
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0256 0.024
Plasmodium vivax hypothetical protein, conserved 0.011 0.037 0.1736
Leishmania major calmodulin, putative 0.0071 0.0202 0.0475
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0061 0.0163 0.0614
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Loa Loa (eye worm) hypothetical protein 0.0083 0.0256 0.0242
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.038 0.1526 1
Loa Loa (eye worm) calpain family protein 1 0.1238 0.5191 0.5185
Toxoplasma gondii calcium binding protein precursor, putative 0.0061 0.0163 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Trichomonas vaginalis centrin, putative 0.0071 0.0202 0.0553
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0326 0.031
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.014 0.05 0.147
Entamoeba histolytica cysteine proteinase 2 0.0106 0.0354 0.2119
Leishmania major phospholipase c-like protein 0.0071 0.0202 0.0475
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0157 0.0141
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0071 0.0202 0.0186
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.038 0.1526 0.1484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0354 0.102
Schistosoma mansoni calmodulin-related 0.0061 0.0163 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Trichomonas vaginalis calcium binding protein, putative 0.0061 0.0163 0.0431
Trichomonas vaginalis calcium binding proteins, putative 0.0071 0.0202 0.0553
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0256 0.0718
Trypanosoma brucei centrin, putative 0.0071 0.0202 0.025
Onchocerca volvulus 0.0035 0.0049 0.0102
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.037 0.0354
Brugia malayi beta-lactamase family protein 0.011 0.037 0.0354
Brugia malayi cathepsin Z-like cysteine proteinase 0.0083 0.0256 0.024
Brugia malayi calpain family protein 1 0.1238 0.5191 0.5183
Schistosoma mansoni nAChR subunit 0.006 0.0157 0.0141
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0532 0.0517
Entamoeba histolytica cysteine protease, putative 0.014 0.0497 0.3083
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.014 0.05 0.147
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.037 0.0886
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0326 0.031
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.038 0.1526 0.1484
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0256 0.024
Entamoeba histolytica calcium-binding protein, putative 0.0071 0.0202 0.11
Schistosoma mansoni fk506 binding protein 0.0052 0.0124 0.0107
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.014 0.05 0.147
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.038 0.1526 1
Mycobacterium ulcerans hypothetical protein 0.011 0.037 0.1755
Trichomonas vaginalis calpain, putative 0.014 0.05 0.147
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0073 0.0156
Trypanosoma cruzi centrin, putative 0.0132 0.0465 0.0418
Trichomonas vaginalis calcium binding protein, putative 0.0132 0.0465 0.1362
Plasmodium falciparum cysteine proteinase falcipain 2a 0.014 0.0497 0.3034
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0028 0.0019 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0256 0.024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0019 0.0002
Giardia lamblia Cathepsin B precursor 0.0788 0.3269 1
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0163 0.0114
Echinococcus multilocularis integrin beta 2 0.0237 0.0914 0.0914
Trichomonas vaginalis calcium binding protein, putative 0.0071 0.0202 0.0553
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0052 0.0124 0.5
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0028 0.0019 0.0002
Loa Loa (eye worm) EF hand family protein 0.0071 0.0202 0.0188
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0025
Loa Loa (eye worm) programmed cell death protein 6 0.0071 0.0202 0.0188
Echinococcus granulosus Myosin regulatory light chain 0.0061 0.0163 0.0146
Schistosoma mansoni hypothetical protein 0.0071 0.0202 0.0186
Echinococcus granulosus cathepsin L cysteine proteinase 0.014 0.0497 0.0481
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0788 0.3269 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0083 0.0256 0.112
Brugia malayi hypothetical protein 0.0073 0.0214 0.0197
Echinococcus granulosus calpain A 0.1309 0.5494 0.5486
Onchocerca volvulus 0.0028 0.0019 0.0006
Trypanosoma cruzi major cysteine proteinase, putative 0.0083 0.0256 0.0208
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0019 0.0002
Echinococcus multilocularis nAChR subunit 0.0032 0.0038 0.0038
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Brugia malayi Neuronal calcium sensor family protein 1 0.0061 0.0163 0.0146
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0083 0.0256 0.14
Echinococcus multilocularis calpain 5 0.0467 0.1896 0.1896
Brugia malayi cathepsin F-like cysteine proteinase 0.0083 0.0256 0.024
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Leishmania major kinesin, putative 0.0327 0.1296 0.3872
Leishmania major calmodulin-like protein 0.0071 0.0202 0.0475
Schistosoma mansoni chromobox protein 0.0072 0.0209 0.0193
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0079 0.0065
Brugia malayi calpain 7 0.0467 0.1896 0.1882
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0079 0.0175
Brugia malayi cathepsin L-like precursor 0.0117 0.0399 0.0383
Plasmodium vivax vivapain-2 0.014 0.0497 0.2426
Entamoeba histolytica hypothetical protein, conserved 0.0071 0.0202 0.11
Echinococcus granulosus geminin 0.0355 0.1419 0.1404
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0341 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0052 0.0124 0.5
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0083 0.0256 0.0242
Echinococcus granulosus GPCR family 2 0.0033 0.0039 0.0023
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0052 0.0124 0.0166
Schistosoma mansoni hypothetical protein 0.0355 0.1419 0.1404
Echinococcus granulosus calpain 0.0467 0.1896 0.1882
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.014 0.05 0.0453
Loa Loa (eye worm) hypothetical protein 0.0117 0.0399 0.0385
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0467 0.1896 0.5634
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.006 0.0157 0.0141
Echinococcus granulosus cathepsin l cysteine peptidase 0.014 0.0497 0.0481
Entamoeba histolytica hypothetical protein 0.0073 0.0214 0.1178
Echinococcus multilocularis geminin 0.0355 0.1419 0.1419
Trypanosoma brucei calpain, putative 0.014 0.05 0.1196
Trichomonas vaginalis immunophilin, putative 0.038 0.1526 0.463
Loa Loa (eye worm) hypothetical protein 0.0061 0.0163 0.0148
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0071 0.0202 0.0202
Onchocerca volvulus 0.0071 0.0202 0.0584
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.006 0.0157 0.0141
Schistosoma mansoni mitochondrial solute carrier 0.0071 0.0202 0.0186
Trichomonas vaginalis centrin, putative 0.0061 0.0163 0.0431
Onchocerca volvulus 0.0032 0.0038 0.0069
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.038 0.1526 0.1526
Trichomonas vaginalis calpain, putative 0.014 0.05 0.147
Brugia malayi Trypsin family protein 0.01 0.0326 0.031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Plasmodium falciparum cysteine proteinase falcipain 3 0.014 0.0497 0.3034
Echinococcus granulosus expressed conserved protein 0.0092 0.0293 0.0277
Mycobacterium ulcerans lipase LipD 0.011 0.037 0.1755
Plasmodium vivax vivapain-2 0.014 0.0497 0.2426
Giardia lamblia Calmodulin 0.0061 0.0163 0.0288
Schistosoma mansoni cathepsin F (C01 family) 0.014 0.0497 0.0481
Schistosoma mansoni hypothetical protein 0.0041 0.0073 0.0056
Brugia malayi beta-lactamase 0.011 0.037 0.0354
Plasmodium falciparum serine repeat antigen 9 0.0083 0.0256 0.14
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0083 0.0256 0.112
Loa Loa (eye worm) hypothetical protein 0.011 0.037 0.0356
Brugia malayi RasGEF domain containing protein 0.0064 0.0172 0.0155
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.014 0.05 0.0453
Trypanosoma brucei calpain-like protein, putative 0.0467 0.1896 0.5634
Plasmodium vivax unspecified product 0.0083 0.0256 0.112
Schistosoma mansoni immunophilin 0.038 0.1526 0.1512
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0028 0.0019 0.0002
Loa Loa (eye worm) hypothetical protein 0.0083 0.0256 0.0242
Loa Loa (eye worm) papain family cysteine protease containing protein 0.014 0.0497 0.0483
Echinococcus multilocularis GPCR, family 2 0.0033 0.0039 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0103 0.0103
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0049 0.0032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0157 0.0141
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.038 0.1526 0.1514
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0354 0.2119
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0071 0.0202 0.025
Onchocerca volvulus 0.006 0.0157 0.0442
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Trypanosoma cruzi calmodulin, putative 0.0071 0.0202 0.0154
Toxoplasma gondii cathepsin CPC2 0.0083 0.0256 0.0642
Trypanosoma brucei Calpain-like protein 1.2 0.014 0.05 0.1196
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0126 0.0109
Echinococcus multilocularis cathepsin L cysteine protease 0.014 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0002
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0124 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0202 0.0553
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.038 0.1526 0.455
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0341 0.0325
Toxoplasma gondii hypothetical protein 0.014 0.05 0.14
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0071 0.0204 0.0156
Loa Loa (eye worm) hypothetical protein 0.1238 0.5191 0.5185
Trypanosoma cruzi cysteine peptidase, putative 0.0106 0.0354 0.0306
Trypanosoma cruzi cysteine protease, putative 0.0106 0.0354 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Entamoeba histolytica hypothetical protein 0.0083 0.0256 0.1461
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0256 0.0718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0124 0.0075
Echinococcus granulosus cathepsin b 0.2363 1 1
Entamoeba histolytica cysteine protease, putative 0.0083 0.0256 0.1461
Plasmodium falciparum serine repeat antigen 2 0.0083 0.0256 0.14
Trypanosoma cruzi conserved protein 0.014 0.05 0.0453
Brugia malayi Cathepsin L-like precursor 0.0117 0.0399 0.0383
Mycobacterium tuberculosis Conserved protein 0.011 0.037 0.0886
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.014 0.05 0.147
Brugia malayi Probable myosin regulatory light chain 0.0061 0.0163 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0103 0.0086
Onchocerca volvulus 0.0032 0.0038 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Loa Loa (eye worm) hypothetical protein 0.011 0.037 0.0356
Trichomonas vaginalis hypothetical protein 0.014 0.05 0.147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0256 0.058
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0019 0.0002
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.006 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0098 0.0318 0.0304
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0071 0.0202 0.11
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Leishmania major calcineurin B subunit, putative 0.0071 0.0202 0.0475
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0421 0.0407
Giardia lamblia Cathepsin L precursor 0.0083 0.0256 0.058
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0028 0.0019 0.0019
Echinococcus multilocularis calpain 0.0467 0.1896 0.1896
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0169 0.0153
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2363 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0106 0.0354 0.0731
Brugia malayi Cathepsin L-like precursor 0.014 0.0497 0.0481
Onchocerca volvulus 0.006 0.0157 0.0442
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0126 0.0318
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0231 0.0888 0.0888
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Echinococcus granulosus neuronal calcium sensor 0.0071 0.0202 0.0186
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.006 0.0157 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0256 0.0718
Loa Loa (eye worm) calpain 0.0467 0.1896 0.1884
Onchocerca volvulus 0.006 0.0157 0.0442
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.037 0.0886
Mycobacterium leprae Probable lipase LipE 0.011 0.037 1
Trichomonas vaginalis centrin, putative 0.0061 0.0163 0.0431
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0354 0.2119
Brugia malayi Heterochromatin protein 1 0.0072 0.0209 0.0193
Brugia malayi Protein kinase domain containing protein 0.0035 0.0049 0.0032
Onchocerca volvulus 0.006 0.0157 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0124 0.0311
Loa Loa (eye worm) hypothetical protein 0.011 0.037 0.0356
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.038 0.1526 1
Brugia malayi CHE-14 protein 0.0042 0.0079 0.0063
Echinococcus multilocularis cathepsin L 0.0106 0.0354 0.0354
Onchocerca volvulus 0.006 0.0157 0.0442
Plasmodium vivax unspecified product 0.0106 0.0354 0.1649
Loa Loa (eye worm) calmodulin-like protein 0.0071 0.0202 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.038 0.1526 1
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0169 0.0169
Brugia malayi Integrin beta pat-3 precursor 0.032 0.1269 0.1254
Echinococcus multilocularis cathepsin l cysteine peptidase 0.014 0.0497 0.0497
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0039 0.0023
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.037 0.0886
Entamoeba histolytica calcium binding family protein 0.0071 0.0202 0.11
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Loa Loa (eye worm) myosin regulatory light chain 1 0.0061 0.0163 0.0148
Plasmodium vivax serine-repeat antigen (SERA) 0.0083 0.0256 0.112
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0325 0.0309
Echinococcus granulosus tar DNA binding protein 0.0063 0.0169 0.0153
Brugia malayi hypothetical protein 0.0028 0.0019 0.0002
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.006 0.0157 0.0141
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Echinococcus multilocularis cathepsin L 0.0083 0.0256 0.0256
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0083 0.0256 0.14
Schistosoma mansoni cathepsin S (C01 family) 0.0083 0.0256 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.037 0.1069
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0256 0.0718
Loa Loa (eye worm) hypothetical protein 0.0052 0.0124 0.0109
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0039 0.0025
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Echinococcus granulosus calpain 5 0.0467 0.1896 0.1882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.014 0.05 0.0453
Loa Loa (eye worm) hypothetical protein 0.2363 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0157 0.0141
Trichomonas vaginalis calmodulin, putative 0.0071 0.0202 0.0553
Toxoplasma gondii calcium-dependent protein kinase 0.0071 0.0204 0.0482
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Giardia lamblia Cathepsin B precursor 0.0788 0.3269 1
Echinococcus granulosus cathepsin l1 0.014 0.0497 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0032 0.0038 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0038 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0126 0.0109
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0052 0.0124 0.0075
Toxoplasma gondii preprocathepsin c precursor, putative 0.0083 0.0256 0.0642
Brugia malayi hypothetical protein 0.0028 0.0019 0.0002
Schistosoma mansoni patched 1 0.0042 0.0079 0.0063
Schistosoma mansoni hypothetical protein 0.0041 0.0073 0.0056
Mycobacterium ulcerans beta-lactamase 0.011 0.037 0.1755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0106 0.0354 0.0338
Schistosoma mansoni calpain-7 (C02 family) 0.0467 0.1896 0.1882
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0256 0.058
Plasmodium falciparum serine repeat antigen 5 0.0083 0.0256 0.14
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.006 0.0157 0.0143
Echinococcus granulosus FK506 binding protein 2 0.0052 0.0124 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0019 0.0002
Schistosoma mansoni centrin-related 0.0071 0.0202 0.0186
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0071 0.0202 0.0154
Trichomonas vaginalis fk506-binding protein, putative 0.0052 0.0124 0.0311
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.037 0.0886
Loa Loa (eye worm) cysteine protease 0.014 0.0497 0.0483
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.0497 0.045
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0052 0.0124 0.0124
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.006 0.0157 0.0141
Echinococcus granulosus neuropeptide receptor A26 0.0496 0.2022 0.2009
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0028 0.0019 0.0004
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0049 0.0035
Echinococcus granulosus neuropeptide s receptor 0.0496 0.2022 0.2009
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0071 0.0202 0.0202
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.037 0.1755
Giardia lamblia Cathepsin L-like protease 0.0083 0.0256 0.058
Brugia malayi fibroinase precursor 0.0083 0.0256 0.024
Plasmodium vivax vivapain-3 0.0106 0.0354 0.1649
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0231 0.0888 0.0873
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0421 0.0407
Schistosoma mansoni myosin regulatory light chain 0.0061 0.0163 0.0146
Leishmania major hypothetical protein, unknown function 0.014 0.05 0.14
Trypanosoma cruzi calmodulin, putative 0.0071 0.0202 0.0154
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0126 0.0174
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Entamoeba histolytica calpain large subunit domain III containing protein 0.0327 0.1296 0.8454
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0052 0.0124 0.0572
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0126 0.0077
Echinococcus multilocularis programmed cell death protein 0.0132 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.01 0.0326 0.0312
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0083 0.0256 0.112
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0318 0.0302
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0032 0.0038 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0256 0.0718
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0256 0.0718
Loa Loa (eye worm) hypothetical protein 0.0035 0.0049 0.0035
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0086 0.0114
Schistosoma mansoni immunophilin 0.0328 0.1302 0.1288
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0083 0.0256 0.112
Schistosoma mansoni calpain C (C02 family) 0.0467 0.1896 0.1882
Loa Loa (eye worm) hypothetical protein 0.0771 0.3195 0.3186
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0106 0.0354 0.0306
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.038 0.1526 0.1512
Echinococcus granulosus EF hand domain containing family member A2 0.0071 0.0202 0.0186
Echinococcus granulosus cathepsin L cysteine protease 0.0106 0.0354 0.0338
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.0399 0.0352
Schistosoma mansoni calmodulin 0.0071 0.0202 0.0186
Echinococcus multilocularis neurocalcin 0.0071 0.0202 0.0202
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0083 0.0256 0.024
Onchocerca volvulus 0.01 0.0326 0.0975
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.0497 0.1187
Echinococcus granulosus cathepsin l1 0.0117 0.0399 0.0383
Onchocerca volvulus 0.0028 0.0019 0.0006
Echinococcus multilocularis musashi 0.0027 0.0017 0.0017
Mycobacterium leprae conserved hypothetical protein 0.011 0.037 1
Loa Loa (eye worm) hypothetical protein 0.0911 0.3795 0.3786
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0061 0.0163 0.0459
Schistosoma mansoni rab 0.0071 0.0202 0.0186
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0126 0.0109
Brugia malayi EF hand family protein 0.0071 0.0202 0.0186
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0126 0.0077
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.014 0.05 0.0453
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1309 0.5494 0.5494
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Giardia lamblia Cysteine protease 0.0083 0.0256 0.058
Brugia malayi calcium-binding protein 0.0071 0.0202 0.0186
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Echinococcus multilocularis glycine receptor subunit beta 0.006 0.0157 0.0157
Entamoeba histolytica hypothetical protein 0.0073 0.0214 0.1178
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0052 0.0124 0.0109
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.014 0.05 0.1196
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Brugia malayi hypothetical protein 0.0028 0.0019 0.0002
Onchocerca volvulus 0.014 0.0497 0.1512
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0038 0.0022
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0083 0.0256 0.112
Brugia malayi TAR-binding protein 0.0063 0.0169 0.0153
Echinococcus multilocularis Calcium binding protein 0.0061 0.0163 0.0163
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1238 0.5191 0.5183
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0028 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0103 0.0086
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0532 0.0517
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0126 0.0007
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.007 0.0144
Loa Loa (eye worm) hypothetical protein 0.0103 0.0341 0.0327
Schistosoma mansoni hypothetical protein 0.0073 0.0214 0.0197
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Brugia malayi Cation transporter family protein 0.006 0.0157 0.0141
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.006 0.0157 0.0141
Loa Loa (eye worm) hypothetical protein 0.0061 0.0163 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0024
Toxoplasma gondii cathepsin CPL 0.014 0.0497 0.1391
Brugia malayi cathepsin L precursor 0.0083 0.0256 0.024
Trichomonas vaginalis calmodulin, putative 0.0132 0.0465 0.1362
Brugia malayi Cathepsin L-like precursor 0.014 0.0497 0.0481
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0498 0.0498
Echinococcus multilocularis cysteine protease 0.014 0.0497 0.0497
Trypanosoma brucei protein kinase, putative 0.0053 0.0126 0.0007
Loa Loa (eye worm) ctsf protein 0.014 0.0497 0.0483
Schistosoma mansoni reticulocalbin 0.0071 0.0202 0.0186
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.038 0.1526 0.4457
Plasmodium falciparum cysteine proteinase falcipain 2b 0.014 0.0497 0.3034
Echinococcus multilocularis 0.0052 0.0124 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0117 0.0399 0.0383
Loa Loa (eye worm) calpain family protein 1 0.0911 0.3795 0.3786
Echinococcus multilocularis neuropeptide s receptor 0.0496 0.2022 0.2022
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0201 0.0185
Loa Loa (eye worm) acetylcholine receptor protein 0.0028 0.0019 0.0004
Echinococcus granulosus chromobox protein 1 0.0072 0.0209 0.0193
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Schistosoma mansoni ef hand domain family member A2 0.0071 0.0202 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.014 0.05 0.0453
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.0143
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0061 0.0163 0.0431
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0126 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0256 0.0718
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0126 0.0239
Schistosoma mansoni hypothetical protein 0.0041 0.0073 0.0056
Trypanosoma brucei cysteine peptidase C (CPC) 0.0788 0.3269 1
Onchocerca volvulus Cathepsin L homolog 0.014 0.0497 0.1512
Trypanosoma cruzi major cysteine proteinase, putative 0.0083 0.0256 0.0208
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.014 0.0497 0.0483
Plasmodium falciparum centrin-1 0.0071 0.0202 0.1037
Schistosoma mansoni nAChR subunit 0.006 0.0157 0.0141
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0052 0.0124 0.0232
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0399 0.2426
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0256 0.0242
Echinococcus granulosus glycine receptor subunit alpha 1 0.006 0.0157 0.0141
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0017 0.0002
Onchocerca volvulus 0.0771 0.3195 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0256 0.0718
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0124 0.0232
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.1856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Echinococcus multilocularis glycine receptor subunit alpha 1 0.006 0.0157 0.0157
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0467 0.1896 0.1856
Schistosoma mansoni neuronal calcium sensor 0.0071 0.0202 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0497 0.1462
Schistosoma mansoni hypothetical protein 0.0071 0.0201 0.0185
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.0497 0.045
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0071 0.0202 0.0186
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Echinococcus multilocularis cysteine protease 0.014 0.0497 0.0497
Giardia lamblia Hypothetical protein 0.0071 0.0202 0.0412
Schistosoma mansoni myosin regulatory light chain 0.0061 0.0163 0.0146
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0071 0.0204 0.084
Trypanosoma cruzi caltractin, putative 0.0071 0.0202 0.0154
Onchocerca volvulus 0.0061 0.0163 0.0459
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0169 0.0155
Schistosoma mansoni calmodulin 0.0071 0.0202 0.0186
Trypanosoma cruzi I/6 autoantigen, putative 0.0071 0.0202 0.0154
Entamoeba histolytica cysteine proteinase, putative 0.014 0.0497 0.3083
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.037 0.0354
Entamoeba histolytica hypothetical protein 0.0073 0.0214 0.1178
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0083 0.0256 0.14
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Echinococcus granulosus chromobox protein 1 0.0072 0.0209 0.0193
Trypanosoma brucei protein I/6 0.0071 0.0202 0.025
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.038 0.1526 0.1484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0497 0.1462
Trypanosoma brucei Calpain-like protein 2 0.014 0.05 0.1196
Entamoeba histolytica calmodulin, putative 0.0071 0.0202 0.11
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0086 0.0196
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.006 0.0157 0.0141
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.006 0.0157 0.0143
Onchocerca volvulus Cathepsin F homolog 0.014 0.0497 0.1512
Leishmania major hypothetical protein, conserved 0.011 0.037 0.0996
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0328 0.1302 0.1302
Trichomonas vaginalis calmodulin-2, putative 0.0071 0.0202 0.0553
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0071 0.0202 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0157 0.0141
Brugia malayi Myosin regulatory light chain 1 0.0061 0.0163 0.0146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.0453
Entamoeba histolytica cysteine protease, putative 0.0083 0.0256 0.1461
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Plasmodium falciparum serine repeat antigen 3 0.0083 0.0256 0.14
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.014 0.05 0.0453
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.006 0.0157 0.0143
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.006 0.0157 0.0141
Trypanosoma cruzi centrin-3 0.0132 0.0465 0.0418
Trypanosoma brucei centrin, putative 0.0071 0.0202 0.025
Plasmodium vivax centrin-1, putative 0.0071 0.0202 0.0829
Giardia lamblia Cysteine protease 0.0083 0.0256 0.058
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0256 0.024
Schistosoma mansoni reticulocalbin 0.0071 0.0202 0.0186
Leishmania major cathepsin L-like protease 0.014 0.0497 0.1391
Schistosoma mansoni hypothetical protein 0.0355 0.1419 0.1404
Echinococcus granulosus programmed cell death protein 6 0.0061 0.0163 0.0146
Echinococcus granulosus glycine receptor subunit beta 0.006 0.0157 0.0141
Loa Loa (eye worm) hypothetical protein 0.0328 0.1302 0.1289
Onchocerca volvulus 0.006 0.0157 0.0442
Schistosoma mansoni hypothetical protein 0.014 0.05 0.0484
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0256 0.024
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0052 0.0124 0.0232
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0052 0.0124 0.0232
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Trypanosoma cruzi cysteine proteinase, putative 0.0106 0.0354 0.0306
Entamoeba histolytica cysteine protease, putative 0.0106 0.0354 0.2119
Mycobacterium tuberculosis Probable hydrolase 0.011 0.037 0.0886
Entamoeba histolytica calmodulin, putative 0.0061 0.0163 0.0834
Schistosoma mansoni neuronal calcium sensor 0.0071 0.0202 0.0186
Brugia malayi cathepsin Z-like cysteine proteinase 0.0083 0.0256 0.024
Giardia lamblia Cathepsin B precursor 0.0083 0.0256 0.058
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0124 0.0232
Brugia malayi Kringle domain containing protein 0.0035 0.0049 0.0032
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0318 0.0318
Trypanosoma brucei antigen, putative 0.0467 0.1896 0.5634
Schistosoma mansoni cathepsin F (C01 family) 0.014 0.0497 0.0481
Plasmodium falciparum calpain 0.014 0.05 0.3053
Loa Loa (eye worm) RNA binding protein 0.0063 0.0169 0.0155
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0467 0.1896 0.1856
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Trypanosoma brucei caltractin, putative 0.0132 0.0465 0.1085
Echinococcus granulosus glycine receptor subunit alpha 1 0.006 0.0157 0.0141
Entamoeba histolytica hypothetical protein 0.0073 0.0214 0.1178
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.006 0.0157 0.0141
Brugia malayi chromobox protein homolog 3 0.0041 0.0073 0.0057
Echinococcus granulosus calcium uptake protein 1 0.0071 0.0202 0.0186
Echinococcus multilocularis nAChR subunit 0.006 0.0157 0.0157
Schistosoma mansoni nAChR subunit 0.006 0.0157 0.0141
Loa Loa (eye worm) hypothetical protein 0.0083 0.0256 0.0242
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Echinococcus multilocularis calcium uptake protein 1 0.0071 0.0202 0.0202
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.014 0.05 0.14
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0256 0.024
Schistosoma mansoni nAChR subunit 0.006 0.0157 0.0141
Echinococcus granulosus nAChR subunit 0.0032 0.0038 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0256 0.0718
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0532 0.0532
Echinococcus multilocularis calumenin 0.0071 0.0202 0.0202
Brugia malayi Cation transporter family protein 0.006 0.0157 0.0141
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1309 0.5494 0.5486
Entamoeba histolytica grainin 2 0.0132 0.0465 0.2866
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0004
Toxoplasma gondii ABC1 family protein 0.011 0.037 0.0996
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0083 0.0256 0.112
Plasmodium falciparum serine repeat antigen 1 0.0083 0.0256 0.14
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0086 0.0199
Giardia lamblia Cathepsin B precursor 0.0083 0.0256 0.058
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.038 0.1526 1
Brugia malayi excitatory GABA receptor EXP-1A 0.006 0.0157 0.0141
Schistosoma mansoni nAChR subunit 0.0028 0.0019 0.0002
Trypanosoma brucei calpain-like protein, putative 0.0467 0.1896 0.5634
Brugia malayi calpain 5 0.014 0.05 0.0484
Toxoplasma gondii EFHC1, putative 0.0071 0.0202 0.0475
Brugia malayi EF hand family protein 0.0071 0.0202 0.0186
Trypanosoma cruzi calpain cysteine peptidase, putative 0.014 0.05 0.0453
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0126 0.0077
Echinococcus multilocularis cathepsin l cysteine peptidase 0.014 0.0497 0.0497
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2363 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0318 0.1881
Echinococcus multilocularis neuropeptide receptor A26 0.0496 0.2022 0.2022
Entamoeba histolytica cysteine protease, putative 0.0083 0.0256 0.1461
Entamoeba histolytica protein kinase, putative 0.0327 0.1298 0.8467
Giardia lamblia Cysteine protease 0.0083 0.0256 0.058
Trichomonas vaginalis myosin light chain 1, putative 0.0071 0.0202 0.0553
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0071 0.0202 0.0553
Loa Loa (eye worm) hypothetical protein 0.0083 0.0256 0.0242

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 40 % Percent inhibition of 10 uM nicotine response in human Nicotinic acetylcholine receptor alpha4-beta2 ChEMBL. 15908213
Inhibition (functional) = 40 % Percent inhibition of 10 uM nicotine response in human Nicotinic acetylcholine receptor alpha4-beta2 ChEMBL. 15908213
Ki (binding) nM Inhibition of [3H]-alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha7 of IMR-32 cells; (-)=Not determined ChEMBL. 15908213
Ki (binding) 0 nM Inhibition of [3H]-alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha7 of IMR-32 cells; (-)=Not determined ChEMBL. 15908213
Ki (binding) = 4.9 nM Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 in human HEK293 cells using [3H]- nicotine as radioligand ChEMBL. 15908213
Ki (binding) = 4.9 nM Inhibition of [3H]-epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells ChEMBL. 15908213
Ki (binding) = 4.9 nM Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 in human HEK293 cells using [3H]- nicotine as radioligand ChEMBL. 15908213
Ki (binding) = 4.9 nM Inhibition of [3H]-epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells ChEMBL. 15908213
Ki (binding) = 340 nM Inhibition of [3H]-alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1-beta1-delta-gamma of electroplax ChEMBL. 15908213
Response (functional) = 20 % Percent response relative to 10 uM nicotine in human Nicotinic acetylcholine receptor alpha4-beta2 ChEMBL. 15908213
Response (functional) = 20 % Percent response relative to 10 uM nicotine in human Nicotinic acetylcholine receptor alpha4-beta2 ChEMBL. 15908213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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