Detailed information for compound 52093

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 493.548 | Formula: C28H31NO7
  • H donors: 1 H acceptors: 4 LogP: 5 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[N+](CC1COC(O1)(c1ccccc1)c1ccccc1)(CCOc1ccccc1)C.OC(=O)C(=O)[O-]
  • InChi: 1S/C26H30NO3.C2H2O4/c1-27(2,18-19-28-24-16-10-5-11-17-24)20-25-21-29-26(30-25,22-12-6-3-7-13-22)23-14-8-4-9-15-23;3-1(4)2(5)6/h3-17,25H,18-21H2,1-2H3;(H,3,4)(H,5,6)/q+1;/p-1
  • InChiKey: WCVUOUODFRTVDL-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor alpha 1D Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1B Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0384 0.0859
Trichomonas vaginalis hypothetical protein 0.0084 0.0471 0.1135
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0068
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0115 0.0064
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.005 0.0226 0.0179
Echinococcus multilocularis cathepsin L 0.005 0.0226 0.0176
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0047 0.0202 0.0727
Echinococcus granulosus cathepsin L 0.005 0.0226 0.0176
Trichomonas vaginalis myosin light chain 1, putative 0.0047 0.0202 0.0276
Brugia malayi cahepsin L-like non-peptiedase homolog 0.005 0.0226 0.0226
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Toxoplasma gondii troponin c, isotype gamma, putative 0.0047 0.0202 0.0415
Plasmodium vivax vivapain-2 0.0087 0.0492 0.2329
Brugia malayi CXXC zinc finger family protein 0.0028 0.0064 0.0064
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2722 0.2684
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.005 0.0226 0.0354
Schistosoma mansoni neuronal calcium sensor 0.0047 0.0202 0.0151
Schistosoma mansoni hypothetical protein 0.0398 0.2722 0.2684
Onchocerca volvulus 0.0047 0.0199 0.0469
Mycobacterium leprae Probable lipase LipE 0.0035 0.0115 0.5
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0202 0.0727
Echinococcus granulosus programmed cell death protein 6 0.0043 0.017 0.012
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Loa Loa (eye worm) calpain 0.0281 0.1883 0.1844
Onchocerca volvulus 0.0087 0.0492 0.1401
Brugia malayi Cathepsin L-like precursor 0.0087 0.0492 0.0492
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0151 0.01
Trypanosoma brucei I/6 autoantigen 0.0047 0.0202 0.0276
Trichomonas vaginalis centrin, putative 0.0043 0.017 0.0177
Loa Loa (eye worm) fibroinase 0.0087 0.0492 0.0446
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0199 0.0148
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Brugia malayi Cathepsin L-like precursor 0.0087 0.0492 0.0492
Entamoeba histolytica cysteine protease, putative 0.005 0.0226 0.0949
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Schistosoma mansoni neuropeptide receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0199 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Giardia lamblia Cathepsin B precursor 0.005 0.0226 0.0492
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.005 0.0226 0.0862
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0087 0.0492 0.1203
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.0492 0.0492
Loa Loa (eye worm) programmed cell death protein 6 0.0047 0.0202 0.0155
Schistosoma mansoni jumonji domain containing protein 0.0075 0.04 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1543 0.4557
Entamoeba histolytica grainin, putative 0.0047 0.0202 0.0738
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0226 0.0226
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0125 0.0074
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Toxoplasma gondii cathepsin CPC2 0.005 0.0226 0.0492
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0187 0.0137
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0115 0.0064
Schistosoma mansoni biogenic amine receptor 0.0047 0.0199 0.0148
Plasmodium vivax vivapain-1 0.0065 0.0334 0.1456
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0047 0.0202 0.0087
Schistosoma mansoni hypothetical protein 0.0084 0.0471 0.0422
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0199 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0079 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis EF hand domain containing family member A2 0.0047 0.0202 0.0151
Entamoeba histolytica cysteine protease, putative 0.005 0.0226 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0334 0.0698
Brugia malayi beta-lactamase 0.0035 0.0115 0.0115
Trypanosoma brucei kinesin, putative 0.0197 0.1276 0.3704
Giardia lamblia Hypothetical protein 0.005 0.0226 0.0492
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0199 0.0199
Onchocerca volvulus 0.0464 0.3198 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.1789
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0226 0.0492
Echinococcus granulosus cathepsin L cysteine proteinase 0.0087 0.0492 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0334 0.0698
Echinococcus granulosus cathepsin L cysteine protease 0.0065 0.0334 0.0284
Onchocerca volvulus 0.005 0.0226 0.0556
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0053
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Onchocerca volvulus 0.0028 0.0064 0.0042
Trypanosoma brucei calmodulin, putative 0.0047 0.0202 0.0276
Schistosoma mansoni myosin regulatory light chain 0.0043 0.017 0.012
Schistosoma mansoni cathepsin B (C01 family) 0.005 0.0226 0.0176
Onchocerca volvulus 0.0047 0.0199 0.0469
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1411 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Echinococcus granulosus mucolipin 3 0.0063 0.0319 0.0269
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0087 0.0492 1
Brugia malayi fibroinase precursor 0.005 0.0226 0.0226
Echinococcus granulosus serotonin receptor 0.0047 0.0199 0.0148
Toxoplasma gondii calcium-dependent protein kinase 0.0047 0.0202 0.0415
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Schistosoma mansoni calpain (C02 family) 0.0281 0.1883 0.1841
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0334 0.0698
Trypanosoma brucei Component of motile flagella 41 0.0047 0.0202 0.0276
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0199 0.0148
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0492 0.0381
Leishmania major centrin, putative 0.0047 0.0202 0.0276
Trichomonas vaginalis calcium binding protein, putative 0.0047 0.0202 0.0276
Loa Loa (eye worm) hypothetical protein 0.005 0.0226 0.0179
Onchocerca volvulus 0.0087 0.0492 0.1401
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0334 0.0334
Loa Loa (eye worm) calpain family protein 1 0.0549 0.3805 0.3775
Toxoplasma gondii calmodulin CAM1 0.0047 0.0202 0.0415
Brugia malayi jmjC domain containing protein 0.0094 0.0539 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0079 0.0028
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0113 0.0062
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0199 0.0148
Onchocerca volvulus 0.0087 0.0492 0.1401
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0047 0.0202 0.0276
Echinococcus granulosus calpain A 0.0792 0.5556 0.5533
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0471 0.1135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Onchocerca volvulus 0.0087 0.0492 0.1401
Brugia malayi Neuronal calcium sensor family protein 1 0.0043 0.017 0.017
Echinococcus multilocularis Calcium binding protein 0.0043 0.017 0.012
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0043 0.017 0.0177
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0199 0.0148
Leishmania major calmodulin-like protein 0.0047 0.0202 0.0276
Schistosoma mansoni neuronal calcium sensor 0.0047 0.0202 0.0151
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Trypanosoma cruzi caltractin, putative 0.0047 0.0202 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0068
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0199 0.0469
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0199 0.0148
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0084 0.0471 0.036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0187 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis EF hand domain containing family member A2 0.0047 0.0202 0.0151
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0281 0.1883 0.1789
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0202 0.0276
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0187 0.0137
Brugia malayi Serotonin receptor 0.0047 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0148
Plasmodium falciparum cysteine proteinase falcipain 3 0.0087 0.0492 1
Loa Loa (eye worm) calpain family protein 1 0.0745 0.5218 0.5195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0199 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.005 0.0226 0.0176
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Echinococcus granulosus calpain 0.0281 0.1883 0.1841
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Trypanosoma cruzi centrin, putative 0.009 0.0508 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0115 0.5
Brugia malayi Bromodomain containing protein 0.0029 0.007 0.007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0226 0.0176
Echinococcus multilocularis serotonin receptor 0.0194 0.1255 0.121
Brugia malayi cathepsin L-like cysteine proteinase 0.005 0.0226 0.0226
Toxoplasma gondii calmodulin CAM2 0.0043 0.017 0.0317
Echinococcus granulosus calpain 5 0.0281 0.1883 0.1841
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0199 0.0148
Echinococcus granulosus neuropeptide receptor 0.0047 0.0199 0.0148
Schistosoma mansoni myosin xvIII 0.0047 0.0199 0.0148
Schistosoma mansoni amine GPCR 0.0047 0.0199 0.0148
Schistosoma mansoni neuronal calcium sensor 0.0047 0.0202 0.0151
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.005 0.0226 0.0179
Echinococcus granulosus jumonji domain containing protein 0.004 0.0151 0.01
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.005 0.0226 0.0354
Trypanosoma cruzi kinesin, putative 0.0197 0.1276 0.1174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0065 0.0334 0.0284
Trypanosoma brucei Calpain-like protein 2 0.0084 0.0471 0.1135
Entamoeba histolytica cysteine proteinase 1, putative 0.0065 0.0334 0.1879
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0334 0.0334
Giardia lamblia Hypothetical protein 0.0047 0.0202 0.0415
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0047 0.0202 0.0151
Schistosoma mansoni hypothetical protein 0.0047 0.0202 0.0151
Toxoplasma gondii preprocathepsin c precursor, putative 0.005 0.0226 0.0492
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Loa Loa (eye worm) hypothetical protein 0.0049 0.0217 0.017
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Entamoeba histolytica cysteine protease, putative 0.0087 0.0492 0.3242
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0288 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0297 0.0247
Schistosoma mansoni myosin regulatory light chain 0.0043 0.017 0.012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0199 0.0148
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.134 0.1298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0187 0.0137
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0047 0.0202 0.0087
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.0334 0.1879
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0084 0.0471 0.1135
Loa Loa (eye worm) hypothetical protein 0.0072 0.0384 0.0338
Trypanosoma cruzi conserved protein 0.0084 0.0471 0.036
Toxoplasma gondii calmodulin, putative 0.0043 0.017 0.0317
Echinococcus multilocularis sex peptide receptor 0.0047 0.0199 0.0148
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Echinococcus multilocularis calpain family protein 1, d 0.0549 0.3805 0.3773
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.005 0.0226 0.0862
Schistosoma mansoni neuropeptide receptor 0.0047 0.0199 0.0148
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0199 0.0148
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0047 0.0202 0.0151
Plasmodium falciparum centrin-1 0.0047 0.0202 0.3121
Schistosoma mansoni amine GPCR 0.0647 0.451 0.4482
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.5642
Brugia malayi Coelomocyte uptake defective protein 5 0.0063 0.0319 0.0319
Schistosoma mansoni centrin-related 0.0047 0.0202 0.0151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0123
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0199 0.0148
Plasmodium vivax unspecified product 0.0065 0.0334 0.1456
Schistosoma mansoni calmodulin 0.0047 0.0202 0.0151
Echinococcus multilocularis calpain 0.0281 0.1883 0.1841
Schistosoma mansoni adenoreceptor 0.0047 0.0199 0.0148
Trypanosoma brucei Calpain-like protein 1.2 0.0084 0.0471 0.1135
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Entamoeba histolytica hypothetical protein 0.005 0.0226 0.0949
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1411 1 1
Trypanosoma brucei calpain-like protein, putative 0.0281 0.1883 0.5642
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0084 0.0471 0.1135
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0047 0.0202 0.0087
Trichomonas vaginalis kakapo, putative 0.0043 0.017 0.0177
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0199 0.0148
Trypanosoma brucei calpain-like protein, putative 0.0281 0.1883 0.5642
Loa Loa (eye worm) hypothetical protein 0.0549 0.3805 0.3775
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.007 0.0022
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Plasmodium vivax vivapain-2 0.0087 0.0492 0.2329
Toxoplasma gondii calcium binding protein precursor, putative 0.0043 0.017 0.0317
Brugia malayi neuropeptide F receptor 0.0047 0.0199 0.0199
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0661 0.461 0.4585
Brugia malayi G-protein coupled receptor 0.0047 0.0199 0.0199
Trypanosoma brucei hypothetical protein 0.0084 0.0471 0.1135
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Loa Loa (eye worm) hypothetical protein 0.0464 0.3198 0.3165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0226 0.0354
Loa Loa (eye worm) hypothetical protein 0.0194 0.1255 0.1213
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.021 0.021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Echinococcus granulosus g protein coupled receptor 0.0047 0.0199 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0202 0.0276
Giardia lamblia Cysteine protease 0.005 0.0226 0.0492
Trichomonas vaginalis centrin, putative 0.0047 0.0202 0.0276
Brugia malayi Cathepsin L-like cysteine proteinase 0.0072 0.0384 0.0384
Trichomonas vaginalis calcium binding protein, putative 0.0047 0.0202 0.0276
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0199 0.0152
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.1789
Loa Loa (eye worm) mucolipin 1 0.0063 0.0319 0.0273
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Echinococcus multilocularis calcyphosin protein 0.0043 0.017 0.012
Onchocerca volvulus 0.0072 0.0384 0.1058
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.1411 1 1
Plasmodium falciparum serine repeat antigen 1 0.005 0.0226 0.3701
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0199 0.0148
Echinococcus granulosus programmed cell death protein 0.009 0.0508 0.046
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Trypanosoma cruzi I/6 autoantigen, putative 0.0047 0.0202 0.0087
Schistosoma mansoni cathepsin F (C01 family) 0.0072 0.0384 0.0335
Leishmania major centrin, putative 0.0047 0.0202 0.0276
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Echinococcus multilocularis calpain 5 0.0281 0.1883 0.1841
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0199 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0137
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0072 0.0384 0.0272
Brugia malayi calpain 7 0.0281 0.1883 0.1883
Loa Loa (eye worm) hypothetical protein 0.0072 0.0384 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0384 0.0859
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0199 0.0148
Brugia malayi RasGEF domain containing protein 0.0043 0.017 0.017
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Echinococcus multilocularis centrin 2 0.0047 0.0202 0.0151
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0202 0.0276
Echinococcus granulosus Calcium binding protein 0.0043 0.017 0.012
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0199 0.0152
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Echinococcus multilocularis neurocalcin 0.0047 0.0202 0.0151
Onchocerca volvulus 0.0047 0.0199 0.0469
Leishmania major calpain family cysteine protease-like protein 0.0084 0.0471 0.1135
Entamoeba histolytica calmodulin, putative 0.0047 0.0202 0.0738
Brugia malayi G protein-coupled receptor 0.0047 0.0199 0.0199
Echinococcus granulosus centrin 2 0.0047 0.0202 0.0151
Trypanosoma brucei calpain, putative 0.0084 0.0471 0.1135
Onchocerca volvulus 0.0047 0.0199 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0226 0.0354
Trypanosoma cruzi calmodulin, putative 0.0047 0.0202 0.0087
Echinococcus granulosus g protein coupled receptor 0.0047 0.0199 0.0148
Plasmodium falciparum serine repeat antigen 2 0.005 0.0226 0.3701
Onchocerca volvulus 0.0047 0.0199 0.0469
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0043 0.017 0.0379
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0199 0.0148
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0047 0.0202 0.0276
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0199 0.0148
Giardia lamblia Cathepsin B precursor 0.005 0.0226 0.0492
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0199 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0087 0.0492 0.0443
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.0226 0.0862
Trypanosoma cruzi kinesin, putative 0.0197 0.1276 0.1174
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0079 0.0028
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0084 0.0471 0.1135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0199 0.0148
Echinococcus multilocularis calbindin 32 0.0047 0.0202 0.0151
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Brugia malayi larval opioid receptor 0.0047 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0087 0.0492 0.0446
Echinococcus granulosus neuropeptide receptor 0.0047 0.0199 0.0148
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0199 0.0148
Brugia malayi calcium-binding protein 0.0047 0.0202 0.0202
Onchocerca volvulus 0.0035 0.0115 0.0203
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0288 0.0238
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0199 0.0148
Giardia lamblia Cysteine protease 0.005 0.0226 0.0492
Schistosoma mansoni opsin-like receptor 0.0047 0.0199 0.0148
Leishmania major protein kinase, putative 0.0047 0.0202 0.0276
Trypanosoma brucei calmodulin, putative 0.0047 0.0202 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0334 0.0698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0079 0.0028
Echinococcus granulosus allatostatin A receptor 0.0047 0.0199 0.0148
Toxoplasma gondii centrin family protein 0.0043 0.017 0.0317
Onchocerca volvulus 0.0234 0.1543 0.4742
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0288 1
Schistosoma mansoni cathepsin F (C01 family) 0.0087 0.0492 0.0443
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Brugia malayi GnHR receptor homolog 0.0047 0.0199 0.0199
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.0334 0.1879
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0492 0.3242
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0199 0.0199
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0792 0.5556 0.5533
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0079 0.0028
Giardia lamblia Cathepsin L-like protease 0.005 0.0226 0.0492
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Brugia malayi Dopamine receptor protein 2 0.0047 0.0199 0.0199
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0199 0.0148
Toxoplasma gondii EFHC1, putative 0.0047 0.0202 0.0415
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0334 0.0221
Giardia lamblia Cathepsin B precursor 0.0471 0.3249 1
Onchocerca volvulus 0.0047 0.0199 0.0469
Echinococcus granulosus fmrfamide receptor 0.0047 0.0199 0.0148
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Leishmania major hypothetical protein, unknown function 0.0084 0.0471 0.1135
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.005 0.0226 0.0862
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0199 0.0148
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0199 0.0148
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0199 0.0148
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0199 0.0148
Entamoeba histolytica calcium binding family protein 0.0047 0.0202 0.0738
Brugia malayi hypothetical protein 0.0035 0.0116 0.0116
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0087 0.0492 0.0446
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Brugia malayi Cathepsin L-like precursor 0.0072 0.0384 0.0384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0226 0.0354
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0115 0.0064
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.005 0.0226 0.3701
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0084 0.0471 0.1135
Echinococcus granulosus g protein coupled receptor 0.0047 0.0199 0.0148
Echinococcus multilocularis programmed cell death protein 0.009 0.0508 0.046
Echinococcus granulosus cathepsin l cysteine peptidase 0.0087 0.0492 0.0443
Entamoeba histolytica cysteine protease, putative 0.005 0.0226 0.0949
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0199 0.0148
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0047 0.0202 0.0276
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.005 0.0226 0.0862
Entamoeba histolytica cysteine protease, putative 0.005 0.0226 0.0949
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0226 0.0492
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0051 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.0334 0.1879
Giardia lamblia Calmodulin 0.0043 0.017 0.0317
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0199 0.0152
Loa Loa (eye worm) myosin regulatory light chain 1 0.0043 0.017 0.0123
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.0492 0.3242
Leishmania major i/6 autoantigen-like protein 0.0047 0.0202 0.0276
Echinococcus granulosus calmodulin 0.0047 0.0202 0.0151
Brugia malayi Dopamine receptor protein 1 0.0047 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Brugia malayi calpain D 0.0084 0.0471 0.0471
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0137
Plasmodium falciparum serine repeat antigen 3 0.005 0.0226 0.3701
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Brugia malayi Serotonin receptor 0.0047 0.0199 0.0199
Leishmania major hypothetical protein, conserved 0.0084 0.0471 0.1135
Schistosoma mansoni cpg binding protein 0.0028 0.0064 0.0013
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.005 0.0226 0.0176
Schistosoma mansoni Mername-AA248 (C02 family) 0.0281 0.1883 0.1841
Trypanosoma brucei Calpain-like protein CALP1.3 0.0084 0.0471 0.1135
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0123
Leishmania major cysteine peptidase A (CPA) 0.0087 0.0492 0.1203
Entamoeba histolytica cysteine protease, putative 0.005 0.0226 0.0949
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.005 0.0226 0.0492
Brugia malayi Cathepsin L-like precursor 0.0087 0.0492 0.0492
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0163
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0199 0.0199
Trypanosoma cruzi calmodulin, putative 0.0047 0.0202 0.0087
Plasmodium falciparum cysteine proteinase falcipain 1 0.0065 0.0334 0.6255
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.0226 0.0949
Loa Loa (eye worm) hypothetical protein 0.005 0.0226 0.0179
Schistosoma mansoni neuropeptide receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Entamoeba histolytica hypothetical protein, conserved 0.0047 0.0202 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0226 0.0354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0187 0.014
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0288 0.0238
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0079 0.0028
Schistosoma mansoni hypothetical protein 0.0047 0.0202 0.0151
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0043 0.017 0.0379
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Trypanosoma brucei mitochondrial calcium uptake 1 0.0047 0.0202 0.0276
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0492 0.0381
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0226 0.0179
Trypanosoma cruzi cysteine protease, putative 0.0065 0.0334 0.0221
Trypanosoma cruzi cysteine proteinase, putative 0.0065 0.0334 0.0221
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0084 0.0471 0.1135
Schistosoma mansoni cpg binding protein 0.003 0.0076 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Schistosoma mansoni biogenic amine receptor 0.0047 0.0199 0.0148
Trypanosoma brucei calpain-like protein, putative 0.0281 0.1883 0.5642
Brugia malayi Myosin regulatory light chain 1 0.0043 0.017 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0199 0.0148
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Onchocerca volvulus Alhambra homolog 0.0029 0.007 0.0059
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0792 0.5556 0.5533
Loa Loa (eye worm) beta-lactamase 0.0035 0.0115 0.0068
Echinococcus granulosus EF hand domain containing family member A2 0.0047 0.0202 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0202 0.0155
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Schistosoma mansoni calpain-7 (C02 family) 0.0281 0.1883 0.1841
Onchocerca volvulus Cathepsin L homolog 0.0087 0.0492 0.1401
Toxoplasma gondii centrin, putative 0.0047 0.0202 0.0415
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0199 0.0199
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0539 0.049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Echinococcus granulosus calumenin 0.0047 0.0202 0.0151
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1471 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0745 0.5218 0.5193
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Schistosoma mansoni amine GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis geminin 0.0164 0.1042 0.0996
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0101 0.0101
Echinococcus granulosus hypothetical protein 0.0047 0.0199 0.0148
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.0226 0.0862
Brugia malayi RE15519p 0.0047 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0226 0.0354
Onchocerca volvulus 0.0047 0.0202 0.0478
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0226 0.0176
Loa Loa (eye worm) cysteine protease 0.0087 0.0492 0.0446
Schistosoma mansoni calmodulin 0.0047 0.0202 0.0151
Plasmodium vivax vivapain-3 0.0065 0.0334 0.1456
Trichomonas vaginalis calmodulin, putative 0.009 0.0508 0.1255
Entamoeba histolytica grainin 2 0.0043 0.017 0.047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0226 0.0354
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trypanosoma brucei cysteine peptidase, putative 0.0084 0.0471 0.1135
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0047 0.0202 0.0087
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.0226 0.0176
Trypanosoma brucei Calpain-like protein 1.1 0.0084 0.0471 0.1135
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0281 0.1883 0.1789
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0199 0.0148
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0199 0.0148
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Brugia malayi Cathepsin L-like precursor 0.0087 0.0492 0.0492
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0047 0.0202 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0148
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0281 0.1883 0.1789
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0047 0.0202 0.0151
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.005 0.0226 0.0862
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.0226 0.0226
Echinococcus granulosus neurocalcin 0.0047 0.0202 0.0151
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1411 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.0334 0.1879
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0199 0.0148
Brugia malayi calpain 5 0.0197 0.1276 0.1276
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0084 0.0471 0.036
Trichomonas vaginalis caltractin, putative 0.0043 0.017 0.0177
Echinococcus granulosus calbindin 32 0.0047 0.0202 0.0151
Onchocerca volvulus 0.0047 0.0199 0.0469
Plasmodium vivax centrin-1, putative 0.0047 0.0202 0.0727
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.0226 0.0226
Toxoplasma gondii cathepsin CPL 0.0087 0.0492 0.1328
Loa Loa (eye worm) hypothetical protein 0.0745 0.5218 0.5195
Brugia malayi calpain family protein 1 0.0745 0.5218 0.5218
Loa Loa (eye worm) ctsf protein 0.0087 0.0492 0.0446
Echinococcus multilocularis serotonin receptor 0.0194 0.1255 0.121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Onchocerca volvulus 0.0035 0.0115 0.0203
Echinococcus granulosus EF hand domain containing family member A2 0.0047 0.0202 0.0151
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0051 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0226 0.0354
Schistosoma mansoni cathepsin S (C01 family) 0.005 0.0226 0.0176
Leishmania major calmodulin, putative 0.0047 0.0202 0.0276
Leishmania major calmodulin, putative 0.0047 0.0202 0.0276
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0289 0.0243
Brugia malayi ORL1-like opioid receptor 0.0047 0.0199 0.0199
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Plasmodium vivax calpain, putative 0.0281 0.1883 1
Echinococcus multilocularis calmodulin 0.0047 0.0202 0.0151
Brugia malayi Melatonin receptor type 1A 0.0047 0.0199 0.0199
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0084 0.0471 0.036
Schistosoma mansoni mucolipin 0.0058 0.0281 0.0231
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0226 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Echinococcus granulosus calcium uptake protein 1 0.0047 0.0202 0.0151
Plasmodium falciparum serine repeat antigen 9 0.005 0.0226 0.3701
Leishmania major programmed cell death 6 protein-like protein 0.0047 0.0202 0.0276
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0199 0.0148
Entamoeba histolytica protein kinase, putative 0.0197 0.1276 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0087 0.0492 0.0443
Trypanosoma brucei antigen, putative 0.0281 0.1883 0.5642
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0226 0.0176
Brugia malayi Dopamine receptor 0.0047 0.0199 0.0199
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0065 0.0334 0.0284
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0084 0.0471 0.036
Brugia malayi PHD-finger family protein 0.0029 0.007 0.007
Brugia malayi Cathepsin L-like precursor 0.0072 0.0384 0.0384
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0043 0.017 0.0555
Giardia lamblia Cysteine protease 0.005 0.0226 0.0492
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0281 0.1883 0.1789
Echinococcus granulosus geminin 0.0164 0.1042 0.0996
Brugia malayi calpain 5 0.0084 0.0471 0.0471
Echinococcus multilocularis cathepsin L 0.0065 0.0334 0.0284
Brugia malayi Probable myosin regulatory light chain 0.0043 0.017 0.017
Brugia malayi Cathepsin L-like precursor 0.0087 0.0492 0.0492
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0281 0.1883 0.1789
Entamoeba histolytica calcium-binding protein, putative 0.0047 0.0202 0.0738
Trypanosoma brucei cysteine peptidase C (CPC) 0.0471 0.3249 1
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0199 0.0152
Trichomonas vaginalis centrin, putative 0.0047 0.0202 0.0276
Giardia lamblia Cathepsin L precursor 0.005 0.0226 0.0492
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Echinococcus granulosus cathepsin l1 0.0072 0.0384 0.0335
Echinococcus granulosus cysteine protease 0.0065 0.0334 0.0284
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0051 0.0051
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0199 0.0199
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0471 0.3249 0.3214
Loa Loa (eye worm) EF hand family protein 0.0047 0.0202 0.0155
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0425
Schistosoma mansoni opsin-like receptor 0.0047 0.0199 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Echinococcus granulosus somatostatin receptor 0.0047 0.0199 0.0148
Schistosoma mansoni calmodulin related calcium binding protein 0.0047 0.0202 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Plasmodium falciparum serine repeat antigen 7 0.005 0.0226 0.3701
Echinococcus granulosus EF HAND 1 calcium binding site 0.0047 0.0202 0.0151
Echinococcus multilocularis peregrin 0.0029 0.007 0.0019
Echinococcus granulosus calcyphosin protein 0.0043 0.017 0.012
Brugia malayi beta-lactamase family protein 0.0035 0.0115 0.0115
Schistosoma mansoni reticulocalbin 0.0047 0.0202 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0115 0.0064
Plasmodium falciparum serine repeat antigen 6 0.005 0.0226 0.3701
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trichomonas vaginalis centrin, putative 0.0043 0.017 0.0177
Entamoeba histolytica calpain large subunit domain III containing protein 0.0197 0.1276 1
Trypanosoma cruzi calmodulin, putative 0.0047 0.0202 0.0087
Echinococcus granulosus cathepsin l1 0.0087 0.0492 0.0443
Schistosoma mansoni biogenic amine receptor 0.0047 0.0199 0.0148
Leishmania major centrin, putative,caltractin, putative 0.0047 0.0202 0.0276
Entamoeba histolytica cysteine protease, putative 0.005 0.0226 0.0949
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2722 0.2684
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0792 0.5556 0.5533
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0199 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.5642
Plasmodium falciparum serine repeat antigen 4 0.005 0.0226 0.3701
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0032
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.0226 0.0176
Onchocerca volvulus 0.0087 0.0492 0.1401
Schistosoma mansoni cathepsin C 0.005 0.0226 0.0176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0199 0.0148
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0087 0.0492 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0199 0.0148
Giardia lamblia Cathepsin B precursor 0.005 0.0226 0.0492
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0199 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0084 0.0471 0.036
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.0226 0.0862
Trypanosoma cruzi centrin, putative 0.009 0.0508 0.0398
Trypanosoma cruzi cysteine proteinase, putative 0.0065 0.0334 0.0221
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.5642
Leishmania major calpain protease-like protein 0.0084 0.0471 0.1135
Onchocerca volvulus 0.003 0.0079 0.0089
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0199 0.0148
Trypanosoma brucei centrin, putative 0.0047 0.0202 0.0276
Echinococcus granulosus cpg binding protein 0.003 0.0076 0.0025
Leishmania major calcineurin B subunit, putative 0.0047 0.0202 0.0276
Brugia malayi intermediate filament protein 0.0026 0.0051 0.0051
Leishmania major kinesin, putative 0.0197 0.1276 0.3704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Onchocerca volvulus 0.0035 0.0115 0.0203
Onchocerca volvulus 0.0047 0.0199 0.0469
Schistosoma mansoni cathepsin F (C01 family) 0.0087 0.0492 0.0443
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0288 0.0551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0226 0.0354
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0199 0.0148
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0125 0.0074
Echinococcus multilocularis cysteine protease 0.0087 0.0492 0.0443
Trypanosoma brucei caltractin, putative 0.009 0.0508 0.1255
Echinococcus granulosus calpain 7 C02 family 0.0281 0.1883 0.1841
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0123
Trichomonas vaginalis calmodulin, putative 0.0043 0.017 0.0177
Echinococcus granulosus neuronal calcium sensor 0.0047 0.0202 0.0151
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0281 0.1883 0.5642
Echinococcus granulosus peregrin 0.0029 0.007 0.0019
Brugia malayi sulfakinin receptor protein 0.0047 0.0199 0.0199
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Giardia lamblia Programmed cell death protein-like protein 0.0043 0.017 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Giardia lamblia Cathepsin L precursor 0.005 0.0226 0.0492
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0199 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0226 0.0354
Trichomonas vaginalis calcineurin B subunit, putative 0.0047 0.0202 0.0276
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0199 0.0152
Brugia malayi Pre-SET motif family protein 0.0205 0.134 0.134
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0199 0.0148
Trypanosoma cruzi I/6 autoantigen, putative 0.0047 0.0202 0.0087
Schistosoma mansoni neuropeptide receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0003
Echinococcus granulosus orexin receptor type 2 0.0047 0.0199 0.0148
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0539 0.049
Echinococcus granulosus cathepsin L 0.0065 0.0334 0.0284
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0199 0.0148
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.036
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0199 0.0148
Echinococcus multilocularis calcium uptake protein 1 0.0047 0.0202 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trypanosoma brucei centrin-3 0.009 0.0508 0.1255
Echinococcus multilocularis hypothetical protein 0.0281 0.1883 0.1841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Giardia lamblia Cathepsin L precursor 0.005 0.0226 0.0492
Loa Loa (eye worm) hypothetical protein 0.0194 0.1255 0.1213
Giardia lamblia Cathepsin B precursor 0.0471 0.3249 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis calpain 7 (C02 family) 0.0281 0.1883 0.1841
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0226 0.0226
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.0384 0.2313
Trypanosoma brucei centrin, putative 0.0047 0.0202 0.0276
Trypanosoma cruzi centrin-3 0.009 0.0508 0.0398
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0116 0.0065
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0047 0.0202 0.0738
Schistosoma mansoni neuronal calcium sensor 0.0047 0.0202 0.0151
Trichomonas vaginalis calcium binding protein, putative 0.0043 0.017 0.0177
Brugia malayi neuropeptide F receptor 0.0047 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0148
Loa Loa (eye worm) hypothetical protein 0.005 0.0226 0.0179
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0252 0.0572
Brugia malayi Cathepsin L-like precursor 0.0087 0.0492 0.0492
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0084 0.0471 0.1135
Echinococcus multilocularis mucolipin 3 0.0063 0.0319 0.0269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Brugia malayi cathepsin L precursor 0.005 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0125 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0226 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0047 0.0202 0.0087
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0084 0.0471 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Plasmodium vivax unspecified product 0.005 0.0226 0.0862
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.0226 0.0226
Echinococcus multilocularis cathepsin b 0.1411 1 1
Plasmodium falciparum serine repeat antigen 8 0.005 0.0226 0.3701
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0115 0.0068
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.0226 0.0949
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.0022
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0199 0.0469
Brugia malayi putative neuropeptide receptor 0.0047 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0072 0.0384 0.0338
Trichomonas vaginalis calmodulin-2, putative 0.0047 0.0202 0.0276
Echinococcus granulosus biogenic amine 5HT receptor 0.0194 0.1255 0.121
Schistosoma mansoni calpain-2 (C02 family) 0.0084 0.0471 0.0422
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0199 0.0152
Trypanosoma brucei calpain-like protein, putative 0.0281 0.1883 0.5642
Giardia lamblia Cathepsin L precursor 0.005 0.0226 0.0492
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0226 0.0179
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Echinococcus multilocularis programmed cell death protein 0.009 0.0508 0.046
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0226 0.0492
Echinococcus multilocularis cpg binding protein 0.003 0.0076 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0064 0.0017
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Onchocerca volvulus Cathepsin F homolog 0.0087 0.0492 0.1401
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0199 0.0148
Onchocerca volvulus 0.0043 0.017 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0199 0.0148
Onchocerca volvulus 0.0047 0.0202 0.0478
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.021 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.005 0.0226 0.0354
Trypanosoma brucei calpain, putative 0.0084 0.0471 0.1135
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0199 0.0148
Echinococcus granulosus sex peptide receptor 0.0047 0.0199 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0137
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0047 0.0202 0.0276
Schistosoma mansoni ef hand domain family member A2 0.0047 0.0202 0.0151
Schistosoma mansoni rab 0.0047 0.0202 0.0151
Schistosoma mansoni calmodulin-related 0.0043 0.017 0.012
Schistosoma mansoni amine GPCR 0.0047 0.0199 0.0148
Loa Loa (eye worm) myosin Light Chain family member 0.0043 0.017 0.0123
Toxoplasma gondii centrin 0.0047 0.0202 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0226 0.0354
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0199 0.0152
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0199 0.0148
Trypanosoma brucei protein I/6 0.0047 0.0202 0.0276
Brugia malayi calpain family protein 1 0.0745 0.5218 0.5218
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.005 0.0226 0.0862
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0199 0.0148
Leishmania major hypothetical protein, conserved 0.0047 0.0202 0.0276
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.005 0.0226 0.3701
Schistosoma mansoni hypothetical protein 0.0164 0.1042 0.0996
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0281 0.1883 0.1789
Schistosoma mansoni mucolipin 0.0063 0.0319 0.0269
Toxoplasma gondii cathepsin B 0.0471 0.3249 1
Entamoeba histolytica calmodulin, putative 0.0043 0.017 0.047
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Echinococcus multilocularis calpain A 0.0792 0.5556 0.5533
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0288 0.1274
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Giardia lamblia Cathepsin B precursor 0.005 0.0226 0.0492
Giardia lamblia Cysteine protease 0.005 0.0226 0.0492
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0199 0.0148
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0288 0.0238
Trichomonas vaginalis calpain, putative 0.0084 0.0471 0.1135
Brugia malayi programmed cell death protein 6 0.0047 0.0202 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0471 0.3249 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0065 0.0334 0.0284
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0492 0.0381
Echinococcus granulosus cathepsin b 0.1411 1 1
Giardia lamblia Cathepsin L precursor 0.005 0.0226 0.0492
Plasmodium falciparum serine repeat antigen 5 0.005 0.0226 0.3701
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1411 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0288 0.0686
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0492 0.0381
Brugia malayi G-protein coupled receptor 0.0047 0.0199 0.0199
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Brugia malayi EF hand family protein 0.0047 0.0202 0.0202
Toxoplasma gondii EF hand domain-containing protein 0.0043 0.017 0.0317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0116 0.0065
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0087 0.0492 0.1203
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.017 0.0177
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0084 0.0471 0.036
Schistosoma mansoni hypothetical protein 0.0035 0.0116 0.0065
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0226 0.0354
Plasmodium falciparum calpain 0.0084 0.0471 0.9495
Echinococcus multilocularis programmed cell death protein 6 0.0043 0.017 0.012
Toxoplasma gondii hypothetical protein 0.0084 0.0471 0.1261
Schistosoma mansoni reticulocalbin 0.0047 0.0202 0.0151
Onchocerca volvulus 0.0047 0.0199 0.0469
Brugia malayi beta-lactamase family protein 0.0035 0.0115 0.0115
Echinococcus multilocularis Myosin regulatory light chain 0.0043 0.017 0.012
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0084 0.0471 0.1261
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0084 0.0471 0.036
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.005 0.0226 0.0862
Schistosoma mansoni calpain C (C02 family) 0.0281 0.1883 0.1841
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0199 0.0148
Echinococcus granulosus cathepsin b 0.1411 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0199 0.0152
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0199 0.0148
Giardia lamblia Hypothetical protein 0.005 0.0226 0.0492
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0065 0.0334 0.0221
Onchocerca volvulus 0.0047 0.0199 0.0469
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0199 0.0148
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0226 0.0112
Onchocerca volvulus 0.0047 0.0199 0.0469
Echinococcus multilocularis calumenin 0.0047 0.0202 0.0151
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0492 0.0381
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.007 0.0019
Onchocerca volvulus 0.0087 0.0492 0.1401
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0084 0.0471 0.036
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Trichomonas vaginalis calcium binding proteins, putative 0.0047 0.0202 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.5642
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0199 0.0148
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0199 0.0148
Brugia malayi cathepsin L-like precursor 0.0072 0.0384 0.0384
Echinococcus multilocularis cathepsin L cysteine protease 0.0087 0.0492 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Onchocerca volvulus 0.0043 0.017 0.0379
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.007 0.0019
Schistosoma mansoni amine GPCR 0.0047 0.0199 0.0148
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Schistosoma mansoni histamine h1 receptor 0.0047 0.0199 0.0148
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0199 0.0148
Toxoplasma gondii cathepsin CPC1 0.005 0.0226 0.0492
Onchocerca volvulus Cathepsin L homolog 0.0087 0.0492 0.1401
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0226 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0226 0.0354
Leishmania major phospholipase c-like protein 0.0047 0.0202 0.0276
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0288 0.0238
Schistosoma mansoni opsin-like receptor 0.0047 0.0199 0.0148
Echinococcus granulosus Myosin regulatory light chain 0.0043 0.017 0.012
Onchocerca volvulus 0.0047 0.0199 0.0469
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0047 0.0202 0.0738
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.005 0.0226 0.3701
Plasmodium falciparum centrin-4 0.0043 0.017 0.2384
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0079 0.0028
Brugia malayi jmjC domain containing protein 0.0036 0.0125 0.0125
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0199 0.0148
Onchocerca volvulus Cathepsin L homolog 0.005 0.0226 0.0556
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.005 0.0226 0.0862
Schistosoma mansoni cpg binding protein 0.003 0.0076 0.0025
Schistosoma mansoni hypothetical protein 0.0164 0.1042 0.0996
Echinococcus multilocularis somatostatin receptor 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Trichomonas vaginalis calcineurin B subunit, putative 0.0047 0.0202 0.0276
Leishmania major cathepsin L-like protease 0.0087 0.0492 0.1203
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0116 0.0065
Trichomonas vaginalis caltractin, putative 0.0043 0.017 0.0177
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0199 0.0148
Loa Loa (eye worm) calpain D 0.0084 0.0471 0.0425
Loa Loa (eye worm) hypothetical protein 0.005 0.0226 0.0179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.021 0.0163
Schistosoma mansoni biogenic amine (5HT) receptor 0.0194 0.1255 0.121
Echinococcus multilocularis cysteine protease 0.0087 0.0492 0.0443
Giardia lamblia Cathepsin L-like protease 0.005 0.0226 0.0492
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0199 0.0148
Entamoeba histolytica cysteine protease, putative 0.0065 0.0334 0.1879
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0199 0.0148
Entamoeba histolytica grainin 2 0.009 0.0508 0.3384
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0084 0.0471 0.1135
Leishmania major calmodulin-like protein 0.0047 0.0202 0.0276
Entamoeba histolytica cysteine proteinase 2 0.0065 0.0334 0.1879
Onchocerca volvulus 0.0047 0.0199 0.0469
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0199 0.0148
Brugia malayi Calmodulin-like protein 0.0047 0.0202 0.0202
Trichomonas vaginalis calcium binding protein, putative 0.0047 0.0202 0.0276
Brugia malayi AKH receptor 0.0047 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.005 0.0226 0.0354
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Loa Loa (eye worm) calpain 5 0.0197 0.1276 0.1234
Trichomonas vaginalis calmodulin, putative 0.0047 0.0202 0.0276
Schistosoma mansoni centrin 0.0047 0.0202 0.0151
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0288 1
Loa Loa (eye worm) cathepsin B 0.0471 0.3249 0.3217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0079 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0125 0.0074
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0226 0.0112
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0047 0.0202 0.0151
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0199 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0115 0.025
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1411 1 1
Brugia malayi hypothetical protein 0.0047 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0226 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0492 0.1203
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0084 0.0471 0.1135
Echinococcus multilocularis calmodulin 0.0047 0.0202 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Loa Loa (eye worm) calmodulin-like protein 0.0047 0.0202 0.0155
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0492 0.0446
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.0226 0.0862
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0199 0.0152
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.1789
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0471 0.3249 1
Echinococcus multilocularis neuronal calcium sensor 0.0047 0.0202 0.0151
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0199 0.0148
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Loa Loa (eye worm) hypothetical protein 0.005 0.0226 0.0179
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0199 0.0148
Onchocerca volvulus 0.0047 0.0199 0.0469
Echinococcus multilocularis cathepsin b 0.1411 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0199 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0084 0.0471 0.1135
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0084 0.0471 0.036
Schistosoma mansoni calpain-7 (C02 family) 0.0281 0.1883 0.1841
Onchocerca volvulus 0.0087 0.0492 0.1401
Schistosoma mansoni myosin light chain 0.0043 0.017 0.012
Onchocerca volvulus 0.0047 0.0199 0.0469
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Leishmania major hypothetical protein, conserved 0.0047 0.0202 0.0276
Trichomonas vaginalis centrin, putative 0.0043 0.017 0.0177
Schistosoma mansoni mitochondrial solute carrier 0.0047 0.0202 0.0151
Giardia lamblia Encystation-specific protease 0.005 0.0226 0.0492
Trichomonas vaginalis calpain, putative 0.0084 0.0471 0.1135
Entamoeba histolytica calpain family cysteine protease, putative 0.0084 0.0471 0.3058
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0199 0.0148
Trichomonas vaginalis calpain, putative 0.0084 0.0471 0.1135
Giardia lamblia Cathepsin B precursor 0.0471 0.3249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0047 0.0202 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.0492 0.1203
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0199 0.0148
Onchocerca volvulus 0.0047 0.0199 0.0469
Onchocerca volvulus 0.0047 0.0202 0.0478
Giardia lamblia Cathepsin L precursor 0.005 0.0226 0.0492
Echinococcus granulosus calpain A 0.0281 0.1883 0.1841
Giardia lamblia Cathepsin B precursor 0.005 0.0226 0.0492
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0471 0.3249 0.317
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0281 0.1883 0.1789
Schistosoma mansoni hypothetical protein 0.0033 0.0101 0.005
Echinococcus multilocularis cathepsin L cysteine protease 0.0087 0.0492 0.0443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.007 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0492 0.1203
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0047 0.0202 0.0151
Plasmodium vivax SET domain protein, putative 0.003 0.0079 0.0051
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0199 0.0148
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0067 0.0016
Toxoplasma gondii ABC1 family protein 0.0035 0.0115 0.0143
Onchocerca volvulus 0.0047 0.0199 0.0469
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0068
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0152
Brugia malayi EF hand family protein 0.0047 0.0202 0.0202
Trichomonas vaginalis calcium binding protein, putative 0.009 0.0508 0.1255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0187 0.0137
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0084 0.0471 0.1135
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0792 0.5556 0.5533
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0199 0.0148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0199 0.0148
Brugia malayi Pre-SET motif family protein 0.003 0.0079 0.0079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0226 0.0176
Entamoeba histolytica calmodulin, putative 0.0047 0.0202 0.0738
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0226 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.017 0.0056
Toxoplasma gondii EF hand domain-containing protein 0.0047 0.0202 0.0415
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0068
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0199 0.0199

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.69 Affinity constant of the compound towards human recombinant Alpha-1B adrenergic receptor using [3H]-prazosin (from CHO cells) as radioligand by radioligand binding assay ChEMBL. 12672251
Ki (binding) = -7.47 Affinity constant of the compound towards human recombinant Alpha-1A adrenergic receptor using [3H]-prazosin (from CHO cells) as radioligand by radioligand binding assay ChEMBL. 12672251
Ki (binding) < -6 Affinity constant of the compound towards human recombinant Alpha-1D adrenergic receptor using [3H]-prazosin (from CHO cells) as radioligand by radioligand binding assay ChEMBL. 12672251
Log Ki (binding) < 6 Affinity constant of the compound towards human recombinant Alpha-1D adrenergic receptor using [3H]-prazosin (from CHO cells) as radioligand by radioligand binding assay ChEMBL. 12672251
Log Ki (binding) = 7.47 Affinity constant of the compound towards human recombinant Alpha-1A adrenergic receptor using [3H]-prazosin (from CHO cells) as radioligand by radioligand binding assay ChEMBL. 12672251
Log Ki (binding) = 7.69 Affinity constant of the compound towards human recombinant Alpha-1B adrenergic receptor using [3H]-prazosin (from CHO cells) as radioligand by radioligand binding assay ChEMBL. 12672251
pKb (functional) < 5 Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) ChEMBL. 12672251
pKb (functional) = 5.6 Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) ChEMBL. 12672251
pKb (functional) = 6.19 Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) ChEMBL. 12672251
pKb (functional) < 5 Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) ChEMBL. 12672251
pKb (functional) = 5.6 Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) ChEMBL. 12672251
pKb (functional) = 6.19 Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) ChEMBL. 12672251
Selectivity (binding) < 0.02 Selectivity of the compound over human alpha1d/alpha1b receptor ChEMBL. 12672251
Selectivity (binding) < 0.03 Selectivity of the compound over human alpha1d/alpha1a receptor ChEMBL. 12672251
Selectivity (functional) < 0.3 Selectivity given as ratio of pKb value against alpha1A receptor to pKb value against alpha1B receptor in rat ChEMBL. 12672251
Selectivity (binding) = 0.6 Selectivity of the compound over alpha1a/alpha1b ChEMBL. 12672251
Selectivity (functional) = 4 Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1B receptor in rat ChEMBL. 12672251
Selectivity (functional) > 15 Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1A receptor in rat ChEMBL. 12672251

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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