Detailed information for compound 915798

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.575 | Formula: C29H32N2O5
  • H donors: 3 H acceptors: 4 LogP: 1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[C@H]1CC2=C(N(C1=O)Cc1ccccc1)[C@H]1[C@]34[C@](C2)(O)[C@@H](Cc2c4c(O1)c(O)cc2)N(C)CC3
  • InChi: 1S/C29H32N2O5/c1-30-11-10-28-23-18-7-8-21(33)25(23)36-26(28)24-20(15-29(28,35)22(30)14-18)13-19(9-12-32)27(34)31(24)16-17-5-3-2-4-6-17/h2-8,19,22,26,32-33,35H,9-16H2,1H3/t19-,22+,26-,28-,29+/m0/s1
  • InChiKey: TWHOEFFOOYPJNA-XXNKRNNASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.0379 0.0373
Schistosoma mansoni ran 0.0022 0.0115 0.0107
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Schistosoma mansoni rab 0.0024 0.0137 0.0133
Echinococcus granulosus neuronal calcium sensor 0.0024 0.0137 0.0147
Toxoplasma gondii cathepsin CPC1 0.0061 0.0601 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Giardia lamblia Cathepsin L-like protease 0.0061 0.0601 0.1594
Entamoeba histolytica calcium-binding protein, putative 0.0024 0.0137 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0221 0.2635 0.5631
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.0379 0.0405
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Echinococcus multilocularis calpain 7 (C02 family) 0.0146 0.1681 0.1675
Loa Loa (eye worm) Smad1 0.0016 0.0034 0.0039
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0061 0.0601 0.0655
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Trichomonas vaginalis calcium binding proteins, putative 0.0024 0.0137 0.0374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0737 0.0808
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.003 0.0213 0.0218
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Loa Loa (eye worm) papain family cysteine protease containing protein 0.024 0.287 0.3226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0737 0.5048
Schistosoma mansoni calpain-7 (C02 family) 0.0149 0.1718 0.1913
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0229 0.0223
Onchocerca volvulus 0.024 0.287 0.616
Echinococcus multilocularis smad 0.0016 0.0034 0.0028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0068 0.0696 0.0662
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0061 0.0601 0.1611
Entamoeba histolytica calpain family cysteine protease, putative 0.0044 0.0387 0.1291
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Plasmodium falciparum plasmepsin V 0.0052 0.049 0.1302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.195 0.6135
Echinococcus multilocularis importin subunit beta 1 0.003 0.0216 0.021
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0052 0.049 0.0483
Onchocerca volvulus 0.024 0.287 0.616
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma brucei calmodulin, putative 0.0025 0.0143 0.0393
Loa Loa (eye worm) hypothetical protein 0.0052 0.049 0.0551
Echinococcus granulosus neurogenic locus notch protein 4 0.0043 0.0379 0.0419
Echinococcus multilocularis neuronal calcium sensor 0.0024 0.0137 0.0131
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Plasmodium falciparum serine repeat antigen 7 0.0061 0.0601 0.1611
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0115 0.0108
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Onchocerca volvulus 0.0115 0.1285 0.2588
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0751 0.0725
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0421 0.0473
Echinococcus granulosus importin subunit beta 1 0.003 0.0216 0.0236
Echinococcus granulosus cathepsin l cysteine peptidase 0.024 0.287 0.3221
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0017
Schistosoma mansoni hypothetical protein 0.0024 0.0137 0.0133
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.021
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Echinococcus granulosus slit 2 protein 0.0043 0.0379 0.0419
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0746 0.0832
Plasmodium falciparum cysteine proteinase falcipain 1 0.0133 0.1521 0.4158
Echinococcus multilocularis cathepsin b 0.0716 0.8895 0.8894
Trichomonas vaginalis centrin, putative 0.0024 0.0137 0.0374
Trypanosoma cruzi cysteine proteinase, putative 0.0133 0.1521 0.1601
Echinococcus multilocularis cathepsin L cysteine protease 0.024 0.287 0.2865
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.0844
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0194 0.0219
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0213 0.0322
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0737 0.2279
Brugia malayi calpain D 0.0044 0.0387 0.0414
Loa Loa (eye worm) calpain family protein 1 0.0387 0.4734 0.5322
Loa Loa (eye worm) hypothetical protein 0.0716 0.8895 1
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Onchocerca volvulus 0.0028 0.0186 0.0109
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0061 0.0601 0.1611
Echinococcus multilocularis EF hand domain containing family member A2 0.0025 0.0143 0.0137
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Plasmodium falciparum plasmepsin IV 0.0052 0.049 0.1302
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0601 0.0676
Trypanosoma cruzi cruzipain precursor, putative 0.024 0.287 0.3137
Brugia malayi cathepsin Z-like cysteine proteinase 0.0061 0.0601 0.0655
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Brugia malayi Blistered cuticle protein 3 0.0374 0.4573 0.513
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Onchocerca volvulus Neurogenic locus notch homolog 0.0043 0.0379 0.0545
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Plasmodium falciparum serine repeat antigen 3 0.0061 0.0601 0.1611
Giardia lamblia Encystation-specific protease 0.0061 0.0601 0.1594
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0061 0.0601 0.0676
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.003 0.0213 0.0615
Echinococcus multilocularis notch 0.0043 0.0379 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0068 0.0696 0.215
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0034 0.0028
Leishmania major hypothetical protein, conserved 0.0025 0.0143 0.0393
Toxoplasma gondii cathepsin CPC2 0.0061 0.0601 0.1611
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0061 0.0601 0.1611
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Echinococcus granulosus transmembrane protease serine 3 0.0115 0.1285 0.1438
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0568 0.1924
Onchocerca volvulus Putative cubilin 0.0043 0.0379 0.0545
Loa Loa (eye worm) Notch2 0.0043 0.0379 0.0426
Brugia malayi cathepsin F-like cysteine proteinase 0.0073 0.0751 0.0824
Loa Loa (eye worm) cathepsin B 0.0263 0.3166 0.356
Echinococcus granulosus tm gpcr rhodopsin 0.0634 0.7857 0.8832
Brugia malayi MH2 domain containing protein 0.0235 0.2808 0.3141
Loa Loa (eye worm) calpain D 0.0044 0.0387 0.0436
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Brugia malayi Pre-SET motif family protein 0.0031 0.0229 0.0236
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Brugia malayi Kelch motif family protein 0.0047 0.0421 0.0452
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi hypothetical protein 0.0053 0.0507 0.055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Trypanosoma brucei metacaspase 5, putative 0.0144 0.1655 0.5196
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0115 0.0302
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0061 0.0601 0.1611
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0737 0.2279
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Brugia malayi prolyl oligopeptidase family protein 0.0083 0.0889 0.0979
Toxoplasma gondii aspartyl protease ASP3 0.03 0.363 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Onchocerca volvulus Slit protein homolog 0.0043 0.0379 0.0545
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0737 0.1113
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0178 0.5
Loa Loa (eye worm) hypothetical protein 0.031 0.3756 0.4223
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0137 0.0374
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Trichomonas vaginalis calcineurin B subunit, putative 0.0025 0.0143 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0387 0.1169
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Brugia malayi calpain family protein 1 0.0387 0.4734 0.5312
Trichomonas vaginalis hypothetical protein 0.0044 0.0387 0.1169
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0115 0.1285 0.1426
Echinococcus multilocularis cathepsin b 0.0716 0.8895 0.8894
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0024 0.0137 0.0374
Plasmodium vivax vivapain-2 0.024 0.287 0.7894
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0061 0.0601 0.1849
Onchocerca volvulus Cathepsin F homolog 0.024 0.287 0.616
Echinococcus granulosus caspase 3 0.0075 0.0778 0.0867
Trichomonas vaginalis centrin, putative 0.0024 0.0137 0.0374
Mycobacterium tuberculosis Conserved protein 0.0071 0.0737 0.1113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Leishmania major calpain protease-like protein 0.0044 0.0387 0.1169
Echinococcus multilocularis neurogenic locus notch protein 4 0.0043 0.0379 0.0373
Schistosoma mansoni protein kinase 0.0122 0.1376 0.1528
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Plasmodium vivax hypothetical protein, conserved 0.003 0.0213 0.0536
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0015
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0071 0.0734 0.9953
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.021
Loa Loa (eye worm) hypothetical protein 0.0113 0.1264 0.1422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0229 0.0236
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Echinococcus multilocularis acylamino acid releasing enzyme 0.003 0.0213 0.0207
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0115 0.0264
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.0379 0.0419
Echinococcus multilocularis protein jagged 2 0.0043 0.0379 0.0373
Brugia malayi beta-lactamase family protein 0.0071 0.0737 0.0808
Onchocerca volvulus Cathepsin L homolog 0.0061 0.0601 0.1046
Loa Loa (eye worm) hypothetical protein 0.0052 0.049 0.0551
Schistosoma mansoni reticulocalbin 0.0024 0.0137 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Onchocerca volvulus Huntingtin homolog 0.013 0.148 0.3027
Brugia malayi Peroxidasin 0.0374 0.4573 0.513
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0568 0.1485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0049 0.0455 0.0511
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0172 0.0187
Brugia malayi Cathepsin L-like precursor 0.0073 0.0751 0.0824
Leishmania major calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.0379 0.0419
Loa Loa (eye worm) integrin beta-2 0.0306 0.3712 0.4173
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0172 0.0193
Toxoplasma gondii preprocathepsin c precursor, putative 0.0061 0.0601 0.1611
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0178 0.0438
Leishmania major hypothetical protein, conserved 0.0024 0.0137 0.0374
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0052 0.049 0.0551
Loa Loa (eye worm) hypothetical protein 0.013 0.148 0.1664
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0071 0.0734 0.2506
Toxoplasma gondii calmodulin CAM1 0.0025 0.0143 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Schistosoma mansoni hypothetical protein 0.0032 0.0239 0.0247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0394
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus multilocularis musashi 0.0029 0.0194 0.0188
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0568 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0061 0.0601 0.1849
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0024 0.0137 0.0133
Loa Loa (eye worm) calmodulin-like protein 0.0024 0.0137 0.0154
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Schistosoma mansoni memapsin-2 (A01 family) 0.0455 0.5593 0.628
Loa Loa (eye worm) fibroinase 0.024 0.287 0.3226
Plasmodium vivax aspartyl protease, putative 0.03 0.363 1
Echinococcus multilocularis cathepsin L 0.0061 0.0601 0.0595
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Brugia malayi Papain family cysteine protease containing protein 0.0133 0.1521 0.1691
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0083 0.0889 0.2762
Leishmania major programmed cell death 6 protein-like protein 0.0024 0.0137 0.0374
Echinococcus granulosus neurocalcin 0.0024 0.0137 0.0147
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0737 0.1113
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Leishmania major calmodulin-like protein 0.0024 0.0137 0.0374
Plasmodium vivax importin-beta 2, putative 0.003 0.0216 0.0545
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0025 0.0143 0.0032
Plasmodium falciparum serine repeat antigen 4 0.0061 0.0601 0.1611
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Plasmodium vivax hypothetical protein, conserved 0.0144 0.1655 0.4529
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0034 0.0039
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus proteasome prosome macropain 0.0071 0.0734 0.0818
Leishmania major phospholipase c-like protein 0.0024 0.0137 0.0374
Echinococcus granulosus neural cadherin 0.0043 0.0379 0.0419
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0601 0.1594
Entamoeba histolytica grainin 2 0.0024 0.0137 0.0413
Leishmania major centrin, putative 0.0024 0.0137 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Onchocerca volvulus 0.0115 0.1285 0.2588
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0716 0.8895 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0737 0.2279
Plasmodium vivax vivapain-1 0.0133 0.1521 0.4158
Schistosoma mansoni laminin gamma-3 chain 0.0043 0.0379 0.0405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0044 0.0387 0.1019
Trypanosoma cruzi calmodulin, putative 0.0024 0.0137 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0167 0.195 0.2192
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.0844
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.0258
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0122 0.1376 0.1541
Mycobacterium ulcerans lipase LipD 0.0071 0.0737 0.5048
Schistosoma mansoni hypothetical protein 0.0115 0.1285 0.1426
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0229 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0601 0.1849
Loa Loa (eye worm) fli-1 protein 0.0219 0.2608 0.2932
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.024 0.287 0.9057
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0061 0.0601 0.2041
Trypanosoma brucei Calpain-like protein CALP1.3 0.0044 0.0387 0.1169
Onchocerca volvulus 0.0051 0.0475 0.0762
Loa Loa (eye worm) cysteine protease 0.024 0.287 0.3226
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0601 0.1594
Plasmodium falciparum plasmepsin IX 0.03 0.363 1
Brugia malayi Importin beta-1 subunit 0.003 0.0216 0.0222
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Schistosoma mansoni integrin alpha-ps 0.0067 0.0681 0.0745
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0229 0.0223
Onchocerca volvulus Peroxidase homolog 0.0374 0.4573 1
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0568 0.0618
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0737 0.0808
Trichomonas vaginalis esterase, putative 0.0071 0.0737 0.2279
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0737 0.0708
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Echinococcus granulosus lamin dm0 0.0029 0.0194 0.0211
Leishmania major cysteine peptidase A (CPA) 0.024 0.287 0.9057
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Plasmodium falciparum serine repeat antigen 1 0.0061 0.0601 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Echinococcus granulosus calumenin 0.0025 0.0143 0.0154
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Echinococcus granulosus notch 0.0043 0.0379 0.0419
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.003 0.0213 0.0536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0413 0.0444
Brugia malayi Ets-domain containing protein 0.0072 0.0746 0.0819
Plasmodium falciparum serine repeat antigen 9 0.0061 0.0601 0.1611
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1521 0.1691
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0013
Schistosoma mansoni caspase-7 (C14 family) 0.031 0.3756 0.421
Entamoeba histolytica hypothetical protein 0.0061 0.0601 0.2041
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0061 0.0601 0.1611
Echinococcus granulosus EF hand domain containing family member A2 0.0024 0.0137 0.0147
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Toxoplasma gondii aspartyl protease 0.0052 0.049 0.1302
Schistosoma mansoni hypothetical protein 0.0024 0.0137 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.1521 0.4771
Loa Loa (eye worm) calpain family protein 1 0.0285 0.3441 0.3868
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0387 0.4734 0.5312
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Onchocerca volvulus Dual oxidase homolog 0.0374 0.4573 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0216 0.0625
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0172 0.0165
Onchocerca volvulus 0.0115 0.1285 0.2588
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0737 0.2279
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Toxoplasma gondii calcium-dependent protein kinase 0.0025 0.0147 0.0353
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.0311
Loa Loa (eye worm) hypothetical protein 0.0047 0.0421 0.0473
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0568 0.0516
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0052 0.049 0.0543
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Brugia malayi Proteasome A-type and B-type family protein 0.0071 0.0734 0.0805
Loa Loa (eye worm) hypothetical protein 0.0144 0.1655 0.186
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Plasmodium vivax plasmepsin IV, putative 0.0052 0.049 0.1302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0274 0.0308
Schistosoma mansoni integrin alpha 0.015 0.1726 0.1923
Schistosoma mansoni ef hand domain family member A2 0.0024 0.0137 0.0133
Echinococcus granulosus lamin 0.0029 0.0194 0.0211
Plasmodium falciparum cysteine proteinase falcipain 2b 0.024 0.287 0.7894
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0737 0.0808
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0737 0.0822
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Brugia malayi Flap endonuclease-1 0.0027 0.0172 0.0172
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0607 0.752 0.8454
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Plasmodium falciparum serine repeat antigen 8 0.0061 0.0601 0.1611
Onchocerca volvulus 0.0043 0.0379 0.0545
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.1655 0.4529
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.3941 0.443
Onchocerca volvulus 0.0061 0.0601 0.1046
Loa Loa (eye worm) prolyl oligopeptidase 0.003 0.0213 0.024
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0737 0.1113
Plasmodium falciparum plasmepsin II 0.0052 0.049 0.1302
Plasmodium falciparum serine repeat antigen 5 0.0061 0.0601 0.1611
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0026 0.0007
Echinococcus multilocularis fibropellin Ia 0.0043 0.0379 0.0373
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.024
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Brugia malayi hypothetical protein 0.0374 0.4573 0.513
Echinococcus granulosus acylamino acid releasing enzyme 0.003 0.0213 0.0232
Echinococcus multilocularis integrin beta 2 0.0227 0.2706 0.2701
Echinococcus granulosus calpain 7 C02 family 0.0146 0.1681 0.1884
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0601 0.0655
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0411 0.504 0.5663
Schistosoma mansoni lamin 0.0029 0.0194 0.0197
Mycobacterium tuberculosis Conserved protein 0.0071 0.0737 0.1113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2559 0.2877
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0025 0.0143 0.0139
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Toxoplasma gondii EGF family domain-containing protein 0.0043 0.0379 0.0995
Echinococcus multilocularis peroxidasin 0.0374 0.4573 0.4569
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Brugia malayi Calmodulin-like protein 0.0024 0.0137 0.0133
Echinococcus granulosus calpain A 0.0146 0.1681 0.1884
Schistosoma mansoni cathepsin s 0.0073 0.0751 0.0824
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Echinococcus granulosus cathepsin b 0.0716 0.8895 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0597 0.065
Giardia lamblia Cathepsin B precursor 0.0263 0.3166 1
Schistosoma mansoni cpg binding protein 0.0028 0.0186 0.0187
Schistosoma mansoni flap endonuclease-1 0.0024 0.0139 0.0135
Brugia malayi CXXC zinc finger family protein 0.0028 0.0186 0.0187
Echinococcus multilocularis calpain family protein 1, d 0.0285 0.3441 0.3436
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0083 0.0889 0.0979
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Brugia malayi hypothetical protein 0.0115 0.1285 0.1426
Schistosoma mansoni Mername-AA248 (C02 family) 0.0146 0.1681 0.1872
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0146 0.1681 0.1784
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0394
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0034 0.0028
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0017
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0167 0.195 0.209
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Schistosoma mansoni survival motor neuron protein 0.0051 0.0475 0.0514
Mycobacterium tuberculosis Conserved protein 0.0071 0.0737 0.1113
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0737 0.0731
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0061 0.0601 0.0655
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0568 0.1743
Echinococcus multilocularis apoptotic protease activating factor 1 0.0166 0.1933 0.1928
Echinococcus multilocularis integrin alpha ps 0.0067 0.0681 0.0675
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Loa Loa (eye worm) beta-lactamase 0.0071 0.0737 0.0828
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Onchocerca volvulus Chorion peroxidase homolog 0.0374 0.4573 1
Giardia lamblia Cathepsin B precursor 0.0263 0.3166 1
Onchocerca volvulus Cathepsin L homolog 0.024 0.287 0.616
Plasmodium falciparum importin beta, putative 0.003 0.0216 0.0545
Echinococcus granulosus cathepsin L 0.0061 0.0601 0.0669
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.0243
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Schistosoma mansoni gabp alpha 0.0072 0.0746 0.0819
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0601 0.0655
Echinococcus granulosus cathepsin L cysteine protease 0.0133 0.1521 0.1704
Loa Loa (eye worm) hypothetical protein 0.0053 0.0507 0.057
Plasmodium falciparum cysteine proteinase falcipain 2a 0.024 0.287 0.7894
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0263 0.3166 1
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Echinococcus granulosus cathepsin l1 0.024 0.287 0.3221
Echinococcus multilocularis snurportin 1 0.0324 0.3941 0.3937
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0024 0.0137 0.0026
Plasmodium vivax plasmepsin V, putative 0.0052 0.049 0.1302
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0411 0.504 0.5656
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0568 0.0806
Onchocerca volvulus 0.0071 0.0737 0.1352
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Echinococcus multilocularis calbindin 32 0.0025 0.0143 0.0137
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0015 0.002 0.0015
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Loa Loa (eye worm) trypsin family protein 0.0115 0.1285 0.1445
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0061 0.0601 0.1849
Echinococcus granulosus EF HAND 1 calcium binding site 0.0024 0.0137 0.0147
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0026 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0015
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0024 0.0137 0.0413
Echinococcus granulosus Mastin 0.0115 0.1285 0.1438
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi Integrin beta pat-3 precursor 0.0306 0.3712 0.416
Trypanosoma cruzi calmodulin, putative 0.0024 0.0137 0.0026
Entamoeba histolytica calmodulin, putative 0.0024 0.0137 0.0413
Brugia malayi cathepsin L-like cysteine proteinase 0.0061 0.0601 0.0655
Trypanosoma brucei Calpain-like protein 1.1 0.0044 0.0387 0.1169
Mycobacterium ulcerans hypothetical protein 0.0071 0.0737 0.5048
Onchocerca volvulus Prolyl endopeptidase homolog 0.0147 0.169 0.3502
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Onchocerca volvulus 0.0052 0.049 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi prolyl oligopeptidase family protein 0.0147 0.169 0.1882
Echinococcus multilocularis protein jagged 1 0.0043 0.0379 0.0373
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0154
Toxoplasma gondii ABC1 family protein 0.0071 0.0737 0.1987
Echinococcus granulosus caspase 0.0219 0.2601 0.2919
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Brugia malayi calpain 7 0.0146 0.1681 0.1872
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0172 0.0065
Plasmodium falciparum serine repeat antigen 6 0.0061 0.0601 0.1611
Entamoeba histolytica cysteine proteinase, putative 0.024 0.287 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0413 0.0444
Brugia malayi beta-lactamase 0.0071 0.0737 0.0808
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0129
Echinococcus granulosus apoptotic protease activating factor 1 0.0166 0.1933 0.2167
Onchocerca volvulus 0.0115 0.1285 0.2588
Toxoplasma gondii hypothetical protein 0.0044 0.0387 0.1019
Onchocerca volvulus 0.0245 0.2935 0.6307
Trypanosoma brucei oligopeptidase b 0.0068 0.0696 0.215
Schistosoma mansoni protein kinase 0.0122 0.1376 0.1528
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0083 0.0889 0.2762
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0216 0.0545
Leishmania major metacaspase, putative 0.0144 0.1655 0.5196
Mycobacterium leprae Probable lipase LipE 0.0071 0.0737 1
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Trypanosoma brucei Metacaspase-4 0.0144 0.1655 0.5196
Schistosoma mansoni calmodulin 0.0024 0.0137 0.0133
Schistosoma mansoni hypothetical protein 0.0115 0.1285 0.1426
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0144 0.0394
Echinococcus multilocularis neurocalcin 0.0024 0.0137 0.0131
Loa Loa (eye worm) hypothetical protein 0.0167 0.195 0.2192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Onchocerca volvulus Huntingtin homolog 0.013 0.148 0.3027
Brugia malayi calcium-binding protein 0.0024 0.0137 0.0133
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1521 0.1691
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Echinococcus granulosus geminin 0.0166 0.1931 0.2165
Onchocerca volvulus 0.0043 0.0379 0.0545
Schistosoma mansoni cell polarity protein 0.0043 0.0379 0.0405
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0568 0.1743
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0146 0.1681 0.5279
Echinococcus granulosus intermediate filament protein 0.0029 0.0194 0.0211
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0133 0.1521 0.1601
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0115 0.1285 0.1426
Echinococcus granulosus caspase 8 0.0144 0.1655 0.1854
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Schistosoma mansoni lamin 0.0029 0.0194 0.0197
Trypanosoma brucei metacaspase MCA2 0.0144 0.1655 0.5196
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0746 0.074
Schistosoma mansoni caspase-3 (C14 family) 0.0219 0.2601 0.2908
Echinococcus multilocularis integrin alpha ps 0.0032 0.0239 0.0232
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0601 0.0554
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0213 0.0679
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.024 0.287 0.3226
Plasmodium falciparum calpain 0.0044 0.0387 0.1019
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.0143 0.0434
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0061 0.0601 0.1611
Schistosoma mansoni slit 0.0043 0.0379 0.0405
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0017
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0716 0.8895 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0061 0.0601 0.1611
Leishmania major i/6 autoantigen-like protein 0.0024 0.0137 0.0374
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Schistosoma mansoni calmodulin related calcium binding protein 0.0024 0.0137 0.0133
Trypanosoma brucei metacaspase 0.0144 0.1655 0.5196
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0144 0.0033
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0263 0.3166 0.3545
Schistosoma mansoni mitochondrial solute carrier 0.0024 0.0137 0.0133
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Plasmodium falciparum plasmepsin VI 0.0052 0.049 0.1302
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0061 0.0601 0.1611
Trypanosoma brucei centrin, putative 0.0024 0.0137 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0024 0.0141 0.003
Giardia lamblia Cathepsin L-like protease 0.0061 0.0601 0.1594
Echinococcus multilocularis cathepsin L cysteine protease 0.024 0.287 0.2865
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Echinococcus granulosus delta-like protein 1 0.0043 0.0379 0.0419
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0144 0.1655 0.1842
Onchocerca volvulus 0.0043 0.0379 0.0545
Echinococcus multilocularis EF hand domain containing family member A2 0.0024 0.0137 0.0131
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.0379 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0413 0.0444
Plasmodium falciparum proteasome subunit beta type-5 0.0071 0.0734 0.1979
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.024 0.287 0.2865
Brugia malayi aspartic protease BmAsp-2, identical 0.0052 0.049 0.053
Trichomonas vaginalis calmodulin-2, putative 0.0024 0.0137 0.0374
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Entamoeba histolytica cysteine proteinase 1, putative 0.0133 0.1521 0.5268
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0024 0.0137 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trypanosoma brucei Component of motile flagella 41 0.0024 0.0137 0.0374
Brugia malayi cathepsin Z-like cysteine proteinase 0.0061 0.0601 0.0655
Echinococcus multilocularis neural cadherin 0.0043 0.0379 0.0373
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0115 0.1285 0.1438
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0213 0.0679
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Plasmodium vivax vivapain-2 0.024 0.287 0.7894
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0178 0.0193
Trichomonas vaginalis calpain, putative 0.0044 0.0387 0.1169
Schistosoma mansoni cathepsin F (C01 family) 0.024 0.287 0.3211
Echinococcus multilocularis centrin 2 0.0024 0.0137 0.0131
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0071 0.0734 0.1108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.024
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Echinococcus multilocularis slit 2 protein 0.0043 0.0379 0.0373
Trypanosoma brucei calpain, putative 0.0044 0.0387 0.1169
Plasmodium falciparum plasmepsin VIII, putative 0.0052 0.049 0.1302
Schistosoma mansoni cathepsin F (C01 family) 0.024 0.287 0.3211
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Echinococcus granulosus snurportin 1 0.0324 0.3941 0.4426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0568 0.0632
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0568 0.3524
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Loa Loa (eye worm) aspartyl protease 6 0.0052 0.049 0.0551
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Echinococcus granulosus caspase 2 0.031 0.3756 0.4218
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0219 0.2601 0.2596
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Leishmania major protein kinase, putative 0.0024 0.0141 0.0386
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Trypanosoma cruzi cysteine protease, putative 0.0133 0.1521 0.1601
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Loa Loa (eye worm) hypothetical protein 0.0044 0.0387 0.0436
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0017
Leishmania major hypothetical protein, conserved 0.0071 0.0737 0.2279
Plasmodium vivax aspartyl proteinase, putative 0.0052 0.049 0.1302
Echinococcus granulosus glycoprotein Antigen 5 0.0115 0.1285 0.1438
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.003 0.0213 0.0615
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4873 0.5475
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0044 0.0387 0.1169
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0475 0.0514
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0061 0.0601 0.1611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0413 0.0407
Schistosoma mansoni hypothetical protein 0.0166 0.1931 0.2153
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0716 0.8895 1
Onchocerca volvulus Peroxidase homolog 0.0374 0.4573 1
Leishmania major calpain family cysteine protease-like protein 0.0044 0.0387 0.1169
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0221 0.2635 0.2957
Echinococcus multilocularis programmed cell death protein 0.0024 0.0137 0.0131
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.0016 0.001
Plasmodium vivax aspartyl protease, putative 0.0052 0.049 0.1302
Plasmodium falciparum metacaspase 1 0.0144 0.1655 0.4529
Loa Loa (eye worm) EF hand family protein 0.0024 0.0137 0.0154
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0061 0.0601 0.0655
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0568 0.1519
Echinococcus granulosus prolyl endopeptidase 0.0147 0.169 0.1894
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0734 0.0705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Echinococcus multilocularis caspase 0.0219 0.2601 0.2596
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Echinococcus multilocularis tumor protein p63 0.0336 0.4091 0.4087
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Loa Loa (eye worm) hypothetical protein 0.024 0.287 0.3226
Brugia malayi hypothetical protein 0.0052 0.049 0.053
Echinococcus multilocularis integrin alpha 3 0.0115 0.1284 0.1278
Trypanosoma brucei caltractin, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0285 0.3441 0.3868
Onchocerca volvulus 0.0374 0.4573 1
Echinococcus granulosus calpain 0.0146 0.1681 0.1884
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0264
Brugia malayi cathepsin F-like cysteine proteinase 0.0061 0.0601 0.0655
Schistosoma mansoni tyrosine kinase 0.0251 0.3005 0.3363
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0172 0.0422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Echinococcus multilocularis protein jagged 1 0.0043 0.0379 0.0373
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0034 0.0017
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trypanosoma cruzi oligopeptidase b 0.0068 0.0696 0.0662
Echinococcus granulosus cathepsin L cysteine proteinase 0.024 0.287 0.3221
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0137 0.0374
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0568 0.0639
Schistosoma mansoni reticulocalbin 0.0025 0.0143 0.0139
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0071 0.0734 0.2029
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Trypanosoma brucei prolyl endopeptidase 0.0147 0.169 0.531
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.2808 0.3156
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0194 0.0197
Toxoplasma gondii aspartyl protease ASP1 0.0052 0.049 0.1302
Echinococcus multilocularis fat cadherin tumor suppressor 0.0043 0.0379 0.0373
Onchocerca volvulus 0.0029 0.0194 0.0129
Trichomonas vaginalis calpain, putative 0.0044 0.0387 0.1169
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Brugia malayi cathepsin L precursor 0.0061 0.0601 0.0655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1279
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0213 0.0615
Schistosoma mansoni integrin beta subunit 0.018 0.2116 0.2362
Brugia malayi Delta serrate ligand family protein 0.0043 0.0379 0.0405
Schistosoma mansoni calpain-7 (C02 family) 0.0149 0.1718 0.1913
Echinococcus granulosus enteropeptidase 0.0115 0.1285 0.1438
Toxoplasma gondii centrin 0.0024 0.0137 0.0326
Plasmodium falciparum plasmepsin III 0.0052 0.049 0.1302
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0737 1
Schistosoma mansoni hypothetical protein 0.0324 0.3941 0.4418
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0178 0.0206
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0716 0.8895 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0601 0.1849
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0043 0.0379 0.0405
Toxoplasma gondii centrin, putative 0.0024 0.0137 0.0326
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Schistosoma mansoni cathepsin D (A01 family) 0.0341 0.4154 0.4658
Echinococcus multilocularis calumenin 0.0025 0.0143 0.0137
Trypanosoma brucei Calpain-like protein 2 0.0044 0.0387 0.1169
Echinococcus granulosus cysteine protease 0.0133 0.1521 0.1704
Trypanosoma cruzi cysteine proteinase, putative 0.0133 0.1521 0.1601
Brugia malayi Cadherin domain containing protein 0.0043 0.0379 0.0405
Plasmodium falciparum peptidase, putative 0.003 0.0213 0.0536
Echinococcus granulosus integrin alpha ps 0.0067 0.0681 0.0758
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0115 0.1285 0.1438
Loa Loa (eye worm) hypothetical protein 0.0052 0.049 0.0551
Echinococcus granulosus protein jagged 2 0.0043 0.0379 0.0419
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0178 0.0171
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) programmed cell death protein 6 0.0025 0.0143 0.0161
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0017
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi Smad1 0.0016 0.0034 0.0017
Plasmodium falciparum centrin-1 0.0024 0.0137 0.0326
Toxoplasma gondii cathepsin B 0.0263 0.3166 0.8717
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0061 0.0601 0.1611
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0411 0.504 0.5656
Brugia malayi cathepsin L-like precursor 0.0167 0.195 0.2175
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Entamoeba histolytica calcium binding family protein 0.0024 0.0137 0.0413
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0071 0.0734 0.227
Echinococcus multilocularis prolyl endopeptidase 0.0147 0.169 0.1685
Loa Loa (eye worm) hypothetical protein 0.0117 0.1319 0.1483
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.1309 0.2155
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0737 0.5048
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0716 0.8895 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0737 0.0708
Trypanosoma cruzi caltractin, putative 0.0024 0.0137 0.0026
Loa Loa (eye worm) hypothetical protein 0.0147 0.169 0.19
Echinococcus granulosus protein jagged 2 0.0043 0.0379 0.0419
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0143 0.0342
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.1521 0.1601
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.1726 0.1923
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Onchocerca volvulus 0.024 0.287 0.616
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0107 0.1188 0.1336
Schistosoma mansoni caspase-7 (C14 family) 0.0219 0.2601 0.2908
Onchocerca volvulus Peroxidasin homolog 0.0374 0.4573 1
Toxoplasma gondii prolyl endopeptidase 0.0147 0.169 0.4628
Toxoplasma gondii hypothetical protein 0.003 0.0213 0.0536
Echinococcus multilocularis cysteine protease 0.024 0.287 0.2865
Leishmania major calmodulin-like protein 0.0024 0.0137 0.0374
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0024 0.0137 0.0147
Echinococcus multilocularis calcium uptake protein 1 0.0025 0.0143 0.0137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0601 0.1849
Trypanosoma cruzi centrin, putative 0.0024 0.0137 0.0026
Echinococcus granulosus cathepsin b 0.0716 0.8895 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0213 0.0679
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0166 0.1933 0.2173
Loa Loa (eye worm) hypothetical protein 0.0167 0.195 0.2192
Onchocerca volvulus 0.0025 0.0143 0.0013
Brugia malayi Fli-1 protein 0.0219 0.2608 0.2917
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0061 0.0601 0.2041
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0737 0.1113
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0213 0.0679
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.1521 0.4771
Entamoeba histolytica cysteine protease, putative 0.024 0.287 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0229 0.0236
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0194 0.0219
Schistosoma mansoni integrin alpha-ps 0.0035 0.0274 0.0286
Brugia malayi Trypsin-like protease protein 5 0.0115 0.1285 0.1426
Onchocerca volvulus 0.0374 0.4573 1
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0024 0.0141 0.003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.0311
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.1264 0.1403
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0737 0.1987
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Loa Loa (eye worm) notch protein 0.0043 0.0379 0.0426
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Echinococcus multilocularis calmodulin 0.0024 0.0137 0.0131
Onchocerca volvulus 0.0029 0.0194 0.0129
Brugia malayi notch-like transmembrane receptor 0.0043 0.0379 0.0405
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0325 0.0847
Echinococcus granulosus integrin alpha 3 0.0115 0.1284 0.1437
Trypanosoma brucei cysteine peptidase C (CPC) 0.0263 0.3166 1
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus tyrosine protein kinase shark 0.0256 0.3079 0.3457
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0568 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0147 0.169 0.1882
Trypanosoma brucei protein I/6 0.0024 0.0137 0.0374
Echinococcus multilocularis cathepsin L 0.0133 0.1521 0.1515
Trypanosoma cruzi calmodulin, putative 0.0024 0.0137 0.0026
Schistosoma mansoni importin beta-1 0.003 0.0216 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Brugia malayi Eukaryotic aspartyl protease family protein 0.0052 0.049 0.053
Loa Loa (eye worm) calpain 0.0146 0.1681 0.189
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0015 0.002 0.0022
Echinococcus multilocularis caspase 3 0.0075 0.0778 0.0771
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0115 0.1285 0.1279
Brugia malayi aspartic protease BmAsp-1, identical 0.0052 0.049 0.053
Echinococcus multilocularis lamin 0.0029 0.0194 0.0188
Onchocerca volvulus 0.0049 0.0455 0.0716
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Plasmodium vivax centrin-1, putative 0.0024 0.0137 0.0326
Trypanosoma cruzi kinesin, putative 0.0102 0.1125 0.115
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0746 0.0839
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0015 0.002 0.0022
Trypanosoma brucei prolyl oligopeptidase, putative 0.0068 0.0696 0.215
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.2808 0.3156
Schistosoma mansoni ran 0.0022 0.0115 0.0107
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Mycobacterium ulcerans beta-lactamase 0.0071 0.0737 0.5048
Trypanosoma brucei calmodulin, putative 0.0024 0.0137 0.0374
Brugia malayi Ets-domain containing protein 0.0072 0.0746 0.0819
Toxoplasma gondii cathepsin CPL 0.024 0.287 0.7894
Entamoeba histolytica hypothetical protein 0.0027 0.0178 0.0555
Plasmodium vivax metacaspase 1, putative 0.0144 0.1655 0.4529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0052 0.049 0.1302
Loa Loa (eye worm) hypothetical protein 0.0387 0.4734 0.5322
Echinococcus granulosus calbindin 32 0.0025 0.0143 0.0154
Echinococcus multilocularis lamin dm0 0.0029 0.0194 0.0188
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0178 0.0438
Toxoplasma gondii exonuclease III APE 0.0058 0.0568 0.1519
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0207 0.0226
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Brugia malayi calpain family protein 1 0.0387 0.4734 0.5312
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Brugia malayi hypothetical protein 0.0166 0.1933 0.2156
Echinococcus granulosus Smad4 0.0016 0.0034 0.0031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0568 0.1743
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0115 0.0122
Trypanosoma brucei centrin-3 0.0024 0.0137 0.0374
Leishmania major oligopeptidase b 0.0068 0.0696 0.215
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0634 0.7857 0.7856
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0073 0.0751 0.0824
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0503
Brugia malayi calpain 5 0.0102 0.1125 0.1245
Echinococcus multilocularis cathepsin l cysteine peptidase 0.024 0.287 0.2865
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0052 0.049 0.1302
Brugia malayi intermediate filament protein 0.0029 0.0194 0.0197
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0186 0.0209
Echinococcus granulosus tumor protein p63 0.0336 0.4091 0.4595
Loa Loa (eye worm) calpain 5 0.0102 0.1125 0.1265
Onchocerca volvulus 0.024 0.287 0.616
Onchocerca volvulus 0.0115 0.1285 0.2588
Trichomonas vaginalis calmodulin, putative 0.0025 0.0143 0.0393
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0213 0.0218
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1521 0.1691
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0061 0.0601 0.1611
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0083 0.0889 0.0882
Echinococcus granulosus calpain A 0.0412 0.5046 0.5669
Echinococcus granulosus calmodulin 0.0024 0.0137 0.0147
Schistosoma mansoni hypothetical protein 0.0166 0.1931 0.2153
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Echinococcus multilocularis caspase 8 0.0144 0.1655 0.1649
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0024 0.0137 0.0131
Trypanosoma brucei I/6 autoantigen 0.0024 0.0137 0.0374
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Brugia malayi calpain 5 0.0044 0.0387 0.0414
Leishmania major calmodulin, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0137 0.0374
Entamoeba histolytica protein kinase, putative 0.0102 0.1129 0.3891
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Echinococcus multilocularis caspase 2 0.031 0.3756 0.3752
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0263 0.3166 0.3476
Trypanosoma cruzi prolyl endopeptidase 0.0147 0.169 0.1794
Echinococcus granulosus fibropellin Ia 0.0043 0.0379 0.0419
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0229 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.1521 0.4771
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0052 0.049 0.0551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.195 0.6135
Brugia malayi Cathepsin L-like precursor 0.0167 0.195 0.2175
Onchocerca volvulus 0.0115 0.1285 0.2588
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Plasmodium falciparum plasmepsin VII 0.0052 0.049 0.1302
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Loa Loa (eye worm) prolyl oligopeptidase 0.0221 0.2635 0.2962
Leishmania major kinesin, putative 0.0102 0.1125 0.3512
Loa Loa (eye worm) hypothetical protein 0.0083 0.0877 0.0986
Plasmodium vivax vivapain-3 0.0133 0.1521 0.4158
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0229 0.0236
Onchocerca volvulus 0.0071 0.0737 0.1352
Echinococcus granulosus programmed cell death protein 0.0024 0.0137 0.0147
Plasmodium vivax calpain, putative 0.0146 0.1681 0.4601
Plasmodium vivax aspartyl protease, putative 0.03 0.363 1
Plasmodium falciparum flap endonuclease 1 0.0027 0.0172 0.0422
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0737 0.1113
Trypanosoma cruzi I/6 autoantigen, putative 0.0024 0.0137 0.0026
Loa Loa (eye worm) hypothetical protein 0.0343 0.4178 0.4697
Echinococcus granulosus cpg binding protein 0.003 0.0206 0.0224
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.0379 0.0373
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0213 0.0112
Trypanosoma cruzi centrin, putative 0.0024 0.0137 0.0026
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Schistosoma mansoni tyrosine kinase 0.0256 0.3079 0.3447
Trypanosoma brucei hypothetical protein 0.0044 0.0387 0.1169
Plasmodium vivax serine-repeat antigen (SERA) 0.0061 0.0601 0.1611
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0083 0.0889 0.2762
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0178 0.0854
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Brugia malayi fibroinase precursor 0.0061 0.0601 0.0655
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0379 0.0405
Trypanosoma brucei antigen, putative 0.0146 0.1681 0.5279
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Trypanosoma brucei mitochondrial calcium uptake 1 0.0024 0.0137 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Echinococcus multilocularis integrin alpha ps 0.0067 0.0681 0.0675
Leishmania major GTP-binding protein, putative 0.0022 0.0115 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Plasmodium vivax serine-repeat antigen (SERA) 0.0061 0.0601 0.1611
Plasmodium falciparum cysteine proteinase falcipain 3 0.024 0.287 0.7894
Echinococcus multilocularis geminin 0.0166 0.1931 0.1925
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Giardia lamblia Hypothetical protein 0.0025 0.0143 0.0093
Loa Loa (eye worm) hypothetical protein 0.0249 0.2988 0.3359
Schistosoma mansoni cathepsin F (C01 family) 0.0167 0.195 0.2175
Echinococcus granulosus integrin alpha ps 0.0032 0.0239 0.0261
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Loa Loa (eye worm) hypothetical protein 0.0032 0.0239 0.0268
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0213 0.0218
Echinococcus granulosus protein jagged 1 0.0043 0.0379 0.0419
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0737 0.1113
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0024 0.0141 0.0386
Trypanosoma cruzi centrin-3 0.0024 0.0137 0.0026
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0024 0.0137 0.0131
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.2752 0.3094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2988 0.3354
Onchocerca volvulus 0.0374 0.4573 1
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Giardia lamblia Cathepsin B precursor 0.0263 0.3166 1
Brugia malayi hypothetical protein 0.0047 0.0421 0.0452
Onchocerca volvulus 0.0167 0.195 0.4087
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0068 0.0696 0.0662
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2988 0.2984
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0022
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.0311
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0517 0.1376
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0568 0.1743
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Echinococcus multilocularis tyrosine protein kinase shark 0.0256 0.3079 0.3075
Schistosoma mansoni intermediate filament proteins 0.0029 0.0194 0.0197
Onchocerca volvulus 0.0052 0.049 0.0794
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0178 0.0438
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0413 0.0458
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Entamoeba histolytica Ran family GTPase 0.0022 0.0115 0.0334
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Entamoeba histolytica cysteine proteinase 2 0.0133 0.1521 0.5268
Schistosoma mansoni hypothetical protein 0.0166 0.1933 0.2156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Brugia malayi hypothetical protein 0.0052 0.049 0.053
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0068 0.0696 0.104
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Onchocerca volvulus Cell death protein 3 homolog 0.031 0.3756 0.8159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Onchocerca volvulus 0.0166 0.1933 0.4048
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0601 0.1849
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0115 0.0264
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0061 0.0601 0.1611
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0601 0.0554
Onchocerca volvulus 0.024 0.287 0.616
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0737 0.2279
Toxoplasma gondii EF hand domain-containing protein 0.0024 0.0137 0.0326
Brugia malayi Papain family cysteine protease containing protein 0.0133 0.1521 0.1691
Onchocerca volvulus 0.0241 0.2885 0.6194
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0044 0.0387 0.0311
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Onchocerca volvulus 0.0043 0.0379 0.0545
Trypanosoma cruzi conserved protein 0.0044 0.0387 0.0311
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0061 0.0601 0.0655
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0503
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0219 0.2601 0.2919
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0734 0.0705
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0413 0.0407
Plasmodium vivax aspartyl proteinase, putative 0.0052 0.049 0.1302
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0737 0.2279
Trypanosoma cruzi metacaspase 5, putative 0.0144 0.1655 0.1754
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0601 0.0655
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.1169
Echinococcus granulosus integrin beta 2 0.0227 0.2706 0.3037
Echinococcus multilocularis Smad4 0.0016 0.0034 0.0028
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0107 0.1188 0.1317
Brugia malayi EF hand family protein 0.0025 0.0143 0.0139
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4873 0.487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0229 0.0236
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Giardia lamblia High cysteine protein 0.0043 0.0379 0.0866
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0068 0.0696 0.215
Schistosoma mansoni calpain C (C02 family) 0.0146 0.1681 0.1872
Plasmodium falciparum serine repeat antigen 2 0.0061 0.0601 0.1611
Trypanosoma cruzi kinesin, putative 0.0102 0.1125 0.115
Trypanosoma brucei metacaspase MCA3 0.0144 0.1655 0.5196
Echinococcus multilocularis proteasome (prosome, macropain) 0.0071 0.0734 0.0728
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Loa Loa (eye worm) hypothetical protein 0.0027 0.0178 0.02
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0147 0.169 0.531
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0044 0.0387 0.1169
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0061 0.0601 0.1594
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0013
Brugia malayi prolyl oligopeptidase family protein 0.0221 0.2635 0.2947
Echinococcus multilocularis calpain 5 0.0146 0.1681 0.1675
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0178 0.0178
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0172 0.0484
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0213 0.0322
Mycobacterium ulcerans proteasome PrcB 0.0071 0.0734 0.5022
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.0844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0135 0.0367
Brugia malayi Angiotensin-converting enzyme family protein 0.0607 0.752 0.8451
Entamoeba histolytica calmodulin, putative 0.0024 0.0137 0.0413
Trypanosoma brucei Calpain-like protein 1.2 0.0044 0.0387 0.1169
Schistosoma mansoni centrin 0.0024 0.0137 0.0133
Schistosoma mansoni ap endonuclease 0.0058 0.0568 0.0618
Echinococcus granulosus cathepsin L 0.0133 0.1521 0.1704
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0072
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.1655 0.4529
Entamoeba histolytica grainin, putative 0.0025 0.0143 0.0434
Loa Loa (eye worm) hypothetical protein 0.0028 0.0188 0.0211
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0413 0.0465
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0263 0.3166 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.0071 0.0734 0.1979
Onchocerca volvulus 0.0043 0.0379 0.0545
Trypanosoma brucei kinesin, putative 0.0102 0.1125 0.3512
Echinococcus granulosus Dipeptidyl peptidase 9 0.0083 0.0889 0.0993
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Brugia malayi Pre-SET motif family protein 0.0215 0.2559 0.2861
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0034 0.0039
Schistosoma mansoni cathepsin B (C01 family) 0.0061 0.0601 0.0655
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0024 0.0137 0.0413
Brugia malayi cathepsin B-like cysteine proteinase 0.0716 0.8895 1
Echinococcus multilocularis calpain 0.0146 0.1681 0.1675
Toxoplasma gondii EFHC1, putative 0.0024 0.0137 0.0326
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0221 0.2635 0.2947
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0379 0.0405
Onchocerca volvulus 0.0071 0.0737 0.1352
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0568 0.1519
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0601 0.0676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Brugia malayi beta-lactamase family protein 0.0071 0.0737 0.0808
Leishmania major proteasome beta 5 subunit, putative 0.0071 0.0734 0.227
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Echinococcus multilocularis enteropeptidase 0.0115 0.1285 0.1279
Echinococcus multilocularis calmodulin 0.0024 0.0137 0.0131
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Brugia malayi RNA, U transporter 1 0.0086 0.0926 0.1021
Brugia malayi hypothetical protein 0.0249 0.2988 0.3345
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.024 0.287 0.9057
Giardia lamblia Hypothetical protein 0.0061 0.0601 0.1594
Loa Loa (eye worm) hypothetical protein 0.0241 0.2885 0.3243
Echinococcus multilocularis programmed cell death protein 0.0024 0.0137 0.0131
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Brugia malayi EF hand family protein 0.0024 0.0137 0.0133
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0737 0.1113
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.0435
Brugia malayi GCC2 and GCC3 family protein 0.0043 0.0379 0.0405
Echinococcus granulosus cathepsin l1 0.0167 0.195 0.2186
Trypanosoma cruzi I/6 autoantigen, putative 0.0024 0.0137 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Schistosoma mansoni protein kinase 0.0122 0.1376 0.1528
Echinococcus granulosus neurogenic locus protein delta 0.0043 0.0379 0.0419
Echinococcus granulosus protein jagged 1 0.0043 0.0379 0.0419
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0052 0.049 0.1494
Brugia malayi hypothetical protein 0.013 0.148 0.1645
Toxoplasma gondii proteasome subunit beta type, putative 0.0071 0.0734 0.1979
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0083 0.0889 0.2408
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.195 0.6773
Echinococcus multilocularis glycoprotein Antigen 5 0.0115 0.1285 0.1279
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0216 0.0625
Schistosoma mansoni cathepsin D (A01 family) 0.0341 0.4154 0.4658
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0034 0.0031
Trichomonas vaginalis ran, putative 0.0022 0.0115 0.0302
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0068 0.0696 0.4682
Echinococcus multilocularis cysteine protease 0.024 0.287 0.2865
Trypanosoma cruzi metacaspase 5, putative 0.0144 0.1655 0.1754
Leishmania major centrin, putative,caltractin, putative 0.0024 0.0137 0.0374
Brugia malayi Pepsin A precursor 0.0052 0.049 0.053
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Loa Loa (eye worm) blistered cuticle protein 3 0.0374 0.4573 0.5141
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0172 0.0484
Mycobacterium tuberculosis Probable peptidase 0.0068 0.0696 0.104
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0568 0.0562
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0061 0.0601 0.1611
Brugia malayi Muscle positioning protein 4 0.0043 0.0379 0.0405
Plasmodium vivax SET domain protein, putative 0.0031 0.0229 0.0581
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Echinococcus granulosus smad 0.0016 0.0034 0.0031
Trypanosoma brucei centrin, putative 0.0024 0.0137 0.0374
Plasmodium vivax unspecified product 0.0073 0.0751 0.2026
Onchocerca volvulus Peroxidasin homolog 0.0374 0.4573 1
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Trichomonas vaginalis set domain proteins, putative 0.0245 0.2935 0.9264
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0043 0.0379 0.0545
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0737 0.0828
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0213 0.0112
Schistosoma mansoni ap endonuclease 0.0058 0.0568 0.0618
Giardia lamblia Hypothetical protein 0.0061 0.0601 0.1594
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0122 0.1376 0.1371
Plasmodium falciparum plasmepsin X 0.03 0.363 1
Echinococcus multilocularis transmembrane protease serine 3 0.0115 0.1285 0.1279
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0751 0.0844
Plasmodium vivax unspecified product 0.0133 0.1521 0.4158
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0107
Leishmania major importin beta-1 subunit, putative 0.0025 0.0144 0.0394
Schistosoma mansoni smad 0.0016 0.0034 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.024 0.287 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0172 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Onchocerca volvulus 0.024 0.287 0.616
Schistosoma mansoni hypothetical protein 0.0398 0.4873 0.5468
Schistosoma mansoni calmodulin 0.0024 0.0137 0.0133
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.0016 0.0009
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Plasmodium vivax unspecified product 0.0061 0.0601 0.1611
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0601 0.1594
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0213 0.0615
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0413 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Onchocerca volvulus 0.024 0.287 0.616
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.013 0.148 0.1664
Schistosoma mansoni hypothetical protein 0.0044 0.0387 0.0414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Schistosoma mansoni calpain (C02 family) 0.0146 0.1681 0.1872
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0221 0.2635 0.263
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0178 0.0178
Schistosoma mansoni peroxidasin 0.0374 0.4573 0.513
Leishmania major hypothetical protein, unknown function 0.0044 0.0387 0.1169
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0071 0.0734 0.227
Schistosoma mansoni peroxidasin 0.0374 0.4573 0.513
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0213 0.0218
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0568 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.1521 0.4771
Loa Loa (eye worm) ctsf protein 0.024 0.287 0.3226
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Leishmania major calcineurin B subunit, putative 0.0024 0.0137 0.0374
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Entamoeba histolytica calpain large subunit domain III containing protein 0.0102 0.1125 0.3878
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Brugia malayi programmed cell death protein 6 0.0024 0.0137 0.0133
Brugia malayi Cadherin domain containing protein 0.0043 0.0379 0.0405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Onchocerca volvulus Cathepsin L homolog 0.024 0.287 0.616
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Schistosoma mansoni cathepsin C 0.0061 0.0601 0.0655
Schistosoma mansoni septate junction protein 0.0043 0.0379 0.0405
Mycobacterium ulcerans hypothetical protein 0.0115 0.1285 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0083 0.0889 0.0883
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0144 0.1655 0.1842
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0071 0.0734 0.0825
Entamoeba histolytica hypothetical protein, conserved 0.003 0.0213 0.0679
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Schistosoma mansoni Smad4 0.0016 0.0034 0.0017
Echinococcus multilocularis Mastin 0.0115 0.1285 0.1279
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.1655 0.4529
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0083 0.0889 0.0882
Brugia malayi Cathepsin L-like cysteine proteinase 0.0167 0.195 0.2175
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0024 0.0137 0.0026
Leishmania major centrin, putative 0.0024 0.0137 0.0374
Echinococcus multilocularis hypothetical protein 0.0146 0.1681 0.1675
Toxoplasma gondii troponin c, isotype gamma, putative 0.0024 0.0137 0.0326
Brugia malayi Cathepsin L-like precursor 0.0167 0.195 0.2175
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Echinococcus granulosus calpain 5 0.0146 0.1681 0.1884
Echinococcus granulosus EF hand domain containing family member A2 0.0025 0.0143 0.0154
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0379 0.0405
Brugia malayi Papain family cysteine protease containing protein 0.024 0.287 0.3211
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Brugia malayi Cell death protein 3 precursor 0.031 0.3756 0.421
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0411 0.504 0.5036
Echinococcus granulosus peroxidasin 0.0374 0.4573 0.5137
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Loa Loa (eye worm) hypothetical protein 0.0062 0.0613 0.069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0503
Schistosoma mansoni cathepsin S (C01 family) 0.0061 0.0601 0.0655
Echinococcus granulosus centrin 2 0.0024 0.0137 0.0147
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0147 0.169 0.1882
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Trichomonas vaginalis calpain, putative 0.0044 0.0387 0.1169
Schistosoma mansoni hypothetical protein 0.0051 0.0475 0.0514
Schistosoma mansoni ets-related 0.0219 0.2608 0.2917
Trypanosoma brucei calpain, putative 0.0044 0.0387 0.1169
Schistosoma mansoni calpain-2 (C02 family) 0.0044 0.0387 0.0414
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0061 0.0601 0.0655
Trichomonas vaginalis myosin light chain 1, putative 0.0024 0.0137 0.0374
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0071 0.0734 0.0805
Schistosoma mansoni centrin-related 0.0024 0.0137 0.0133
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0017
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0068 0.0696 0.9337
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0751 0.0725
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0213 0.0679
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0172 0.0534
Plasmodium falciparum metacaspase-like protein 0.0144 0.1655 0.4529
Loa Loa (eye worm) hypothetical protein 0.0029 0.0194 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.0379 0.0373
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0172 0.0422
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Echinococcus granulosus calcium uptake protein 1 0.0025 0.0143 0.0154
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0024 0.0137 0.0374
Plasmodium falciparum plasmepsin I 0.0052 0.049 0.1302
Echinococcus multilocularis calpain A 0.0412 0.5046 0.5042
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0413 0.0444
Onchocerca volvulus 0.0031 0.0229 0.0208
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Trichomonas vaginalis calcineurin B subunit, putative 0.0024 0.0137 0.0374
Echinococcus granulosus flap endonuclease 1 0.0027 0.0172 0.0186
Trypanosoma cruzi oligopeptidase b 0.0068 0.0696 0.0662
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0455 0.049
Echinococcus multilocularis cpg binding protein 0.003 0.0206 0.0199
Leishmania major hypothetical protein, conserved 0.0044 0.0387 0.1169
Trypanosoma brucei cysteine peptidase, putative 0.0044 0.0387 0.1169

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 36 % Agonist activity at human recombinant mu opioid receptor expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay relative to DAMGO ChEMBL. 24973818
Activity (functional) = 68 % Agonist activity at human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay relative to DPDPE ChEMBL. 24973818
EC50 (functional) = 10.6 nM Agonist activity at human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay ChEMBL. 24973818
EC50 (functional) = 94.9 nM Agonist activity at human recombinant mu opioid receptor expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay ChEMBL. 24973818
Ke (functional) = 16.8 nM Antagonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes assessed as inhibition of U69593-induced response after 60 mins by [35S]GTPgammaS binding assay ChEMBL. 24973818
Ki (binding) = 2.85 nM Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method ChEMBL. 24973818
Ki (binding) = 3 nM Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method ChEMBL. 24973818
Ki (binding) = 15.6 nM Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method ChEMBL. 24973818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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