Detailed information for compound 916100

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.575 | Formula: C29H32N2O5
  • H donors: 3 H acceptors: 4 LogP: 1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[C@@H]1CC2=C(N(C1=O)Cc1ccccc1)[C@H]1[C@]34[C@](C2)(O)[C@@H](Cc2c4c(O1)c(O)cc2)N(C)CC3
  • InChi: 1S/C29H32N2O5/c1-30-11-10-28-23-18-7-8-21(33)25(23)36-26(28)24-20(15-29(28,35)22(30)14-18)13-19(9-12-32)27(34)31(24)16-17-5-3-2-4-6-17/h2-8,19,22,26,32-33,35H,9-16H2,1H3/t19-,22-,26+,28+,29-/m1/s1
  • InChiKey: TWHOEFFOOYPJNA-FZYDWYOPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase 1, putative 0.0133 0.1521 0.5268
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Trichomonas vaginalis calmodulin-2, putative 0.0024 0.0137 0.0374
Brugia malayi aspartic protease BmAsp-2, identical 0.0052 0.049 0.053
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trypanosoma brucei Component of motile flagella 41 0.0024 0.0137 0.0374
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0024 0.0137 0.0026
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Echinococcus multilocularis neural cadherin 0.0043 0.0379 0.0373
Brugia malayi cathepsin Z-like cysteine proteinase 0.0061 0.0601 0.0655
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0213 0.0679
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0115 0.1285 0.1438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0071 0.0734 0.1108
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Trichomonas vaginalis calpain, putative 0.0044 0.0387 0.1169
Schistosoma mansoni cathepsin F (C01 family) 0.024 0.287 0.3211
Echinococcus multilocularis centrin 2 0.0024 0.0137 0.0131
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0178 0.0193
Plasmodium vivax vivapain-2 0.024 0.287 0.7894
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.024
Plasmodium falciparum plasmepsin VIII, putative 0.0052 0.049 0.1302
Echinococcus multilocularis slit 2 protein 0.0043 0.0379 0.0373
Trypanosoma brucei calpain, putative 0.0044 0.0387 0.1169
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0568 0.3524
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Echinococcus granulosus snurportin 1 0.0324 0.3941 0.4426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0568 0.0632
Schistosoma mansoni cathepsin F (C01 family) 0.024 0.287 0.3211
Trypanosoma brucei metacaspase MCA2 0.0144 0.1655 0.5196
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Echinococcus granulosus caspase 8 0.0144 0.1655 0.1854
Schistosoma mansoni lamin 0.0029 0.0194 0.0197
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0115 0.1285 0.1426
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0601 0.0554
Echinococcus multilocularis integrin alpha ps 0.0032 0.0239 0.0232
Schistosoma mansoni caspase-3 (C14 family) 0.0219 0.2601 0.2908
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0746 0.074
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.0143 0.0434
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Plasmodium falciparum calpain 0.0044 0.0387 0.1019
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.024 0.287 0.3226
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0213 0.0679
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0061 0.0601 0.1611
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0716 0.8895 1
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0017
Schistosoma mansoni slit 0.0043 0.0379 0.0405
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0061 0.0601 0.1611
Schistosoma mansoni mitochondrial solute carrier 0.0024 0.0137 0.0133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0263 0.3166 0.3545
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0144 0.0033
Trypanosoma brucei metacaspase 0.0144 0.1655 0.5196
Schistosoma mansoni calmodulin related calcium binding protein 0.0024 0.0137 0.0133
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Leishmania major i/6 autoantigen-like protein 0.0024 0.0137 0.0374
Giardia lamblia Cathepsin L-like protease 0.0061 0.0601 0.1594
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Echinococcus multilocularis cathepsin L cysteine protease 0.024 0.287 0.2865
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0024 0.0141 0.003
Trypanosoma brucei centrin, putative 0.0024 0.0137 0.0374
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0061 0.0601 0.1611
Plasmodium falciparum plasmepsin VI 0.0052 0.049 0.1302
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Echinococcus granulosus delta-like protein 1 0.0043 0.0379 0.0419
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0144 0.1655 0.1842
Echinococcus multilocularis cathepsin l cysteine peptidase 0.024 0.287 0.2865
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Plasmodium falciparum proteasome subunit beta type-5 0.0071 0.0734 0.1979
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0413 0.0444
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.0379 0.0373
Onchocerca volvulus 0.0043 0.0379 0.0545
Echinococcus multilocularis EF hand domain containing family member A2 0.0024 0.0137 0.0131
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Echinococcus granulosus prolyl endopeptidase 0.0147 0.169 0.1894
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0568 0.1519
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0061 0.0601 0.0655
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0734 0.0705
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Echinococcus multilocularis tumor protein p63 0.0336 0.4091 0.4087
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Echinococcus multilocularis caspase 0.0219 0.2601 0.2596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Brugia malayi hypothetical protein 0.0052 0.049 0.053
Loa Loa (eye worm) hypothetical protein 0.024 0.287 0.3226
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Brugia malayi cathepsin F-like cysteine proteinase 0.0061 0.0601 0.0655
Echinococcus granulosus calpain 0.0146 0.1681 0.1884
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0264
Onchocerca volvulus 0.0374 0.4573 1
Echinococcus multilocularis integrin alpha 3 0.0115 0.1284 0.1278
Trypanosoma brucei caltractin, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0285 0.3441 0.3868
Echinococcus multilocularis protein jagged 1 0.0043 0.0379 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Schistosoma mansoni tyrosine kinase 0.0251 0.3005 0.3363
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0172 0.0422
Echinococcus granulosus cathepsin L cysteine proteinase 0.024 0.287 0.3221
Trypanosoma cruzi oligopeptidase b 0.0068 0.0696 0.0662
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0034 0.0017
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Schistosoma mansoni reticulocalbin 0.0025 0.0143 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0137 0.0374
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0568 0.0639
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Loa Loa (eye worm) aspartyl protease 6 0.0052 0.049 0.0551
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Echinococcus granulosus caspase 2 0.031 0.3756 0.4218
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Leishmania major protein kinase, putative 0.0024 0.0141 0.0386
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0219 0.2601 0.2596
Leishmania major hypothetical protein, conserved 0.0071 0.0737 0.2279
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0017
Loa Loa (eye worm) hypothetical protein 0.0044 0.0387 0.0436
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Trypanosoma cruzi cysteine protease, putative 0.0133 0.1521 0.1601
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Plasmodium vivax aspartyl proteinase, putative 0.0052 0.049 0.1302
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0061 0.0601 0.1611
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0475 0.0514
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0044 0.0387 0.1169
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.003 0.0213 0.0615
Echinococcus granulosus glycoprotein Antigen 5 0.0115 0.1285 0.1438
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4873 0.5475
Leishmania major calpain family cysteine protease-like protein 0.0044 0.0387 0.1169
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0221 0.2635 0.2957
Onchocerca volvulus Peroxidase homolog 0.0374 0.4573 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0716 0.8895 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Schistosoma mansoni hypothetical protein 0.0166 0.1931 0.2153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0413 0.0407
Loa Loa (eye worm) EF hand family protein 0.0024 0.0137 0.0154
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Plasmodium falciparum metacaspase 1 0.0144 0.1655 0.4529
Plasmodium vivax aspartyl protease, putative 0.0052 0.049 0.1302
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.0016 0.001
Echinococcus multilocularis programmed cell death protein 0.0024 0.0137 0.0131
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0025 0.0143 0.0139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2559 0.2877
Schistosoma mansoni lamin 0.0029 0.0194 0.0197
Mycobacterium tuberculosis Conserved protein 0.0071 0.0737 0.1113
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0411 0.504 0.5663
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0601 0.0655
Echinococcus granulosus calpain 7 C02 family 0.0146 0.1681 0.1884
Echinococcus granulosus calpain A 0.0146 0.1681 0.1884
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Brugia malayi Calmodulin-like protein 0.0024 0.0137 0.0133
Echinococcus multilocularis peroxidasin 0.0374 0.4573 0.4569
Toxoplasma gondii EGF family domain-containing protein 0.0043 0.0379 0.0995
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Brugia malayi CXXC zinc finger family protein 0.0028 0.0186 0.0187
Schistosoma mansoni cpg binding protein 0.0028 0.0186 0.0187
Giardia lamblia Cathepsin B precursor 0.0263 0.3166 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0597 0.065
Schistosoma mansoni flap endonuclease-1 0.0024 0.0139 0.0135
Echinococcus granulosus cathepsin b 0.0716 0.8895 1
Schistosoma mansoni cathepsin s 0.0073 0.0751 0.0824
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Schistosoma mansoni Mername-AA248 (C02 family) 0.0146 0.1681 0.1872
Brugia malayi hypothetical protein 0.0115 0.1285 0.1426
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Echinococcus multilocularis calpain family protein 1, d 0.0285 0.3441 0.3436
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0083 0.0889 0.0979
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0017
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0034 0.0028
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0394
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0146 0.1681 0.1784
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Schistosoma mansoni survival motor neuron protein 0.0051 0.0475 0.0514
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0167 0.195 0.209
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0568 0.1743
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0061 0.0601 0.0655
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0737 0.0731
Mycobacterium tuberculosis Conserved protein 0.0071 0.0737 0.1113
Loa Loa (eye worm) beta-lactamase 0.0071 0.0737 0.0828
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Echinococcus multilocularis integrin alpha ps 0.0067 0.0681 0.0675
Echinococcus multilocularis apoptotic protease activating factor 1 0.0166 0.1933 0.1928
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Toxoplasma gondii calcium-dependent protein kinase 0.0025 0.0147 0.0353
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0737 0.2279
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Onchocerca volvulus 0.0115 0.1285 0.2588
Loa Loa (eye worm) hypothetical protein 0.0047 0.0421 0.0473
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.0311
Plasmodium vivax plasmepsin IV, putative 0.0052 0.049 0.1302
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Loa Loa (eye worm) hypothetical protein 0.0144 0.1655 0.186
Brugia malayi Proteasome A-type and B-type family protein 0.0071 0.0734 0.0805
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0052 0.049 0.0543
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0568 0.0516
Plasmodium falciparum cysteine proteinase falcipain 2b 0.024 0.287 0.7894
Echinococcus granulosus lamin 0.0029 0.0194 0.0211
Schistosoma mansoni ef hand domain family member A2 0.0024 0.0137 0.0133
Schistosoma mansoni integrin alpha 0.015 0.1726 0.1923
Loa Loa (eye worm) hypothetical protein 0.0035 0.0274 0.0308
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0607 0.752 0.8454
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Brugia malayi Flap endonuclease-1 0.0027 0.0172 0.0172
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0737 0.0822
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0737 0.0808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.3941 0.443
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.1655 0.4529
Onchocerca volvulus 0.0043 0.0379 0.0545
Plasmodium falciparum serine repeat antigen 8 0.0061 0.0601 0.1611
Echinococcus multilocularis fibropellin Ia 0.0043 0.0379 0.0373
Plasmodium falciparum serine repeat antigen 5 0.0061 0.0601 0.1611
Plasmodium falciparum plasmepsin II 0.0052 0.049 0.1302
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0026 0.0007
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0737 0.1113
Loa Loa (eye worm) prolyl oligopeptidase 0.003 0.0213 0.024
Onchocerca volvulus 0.0061 0.0601 0.1046
Echinococcus multilocularis integrin beta 2 0.0227 0.2706 0.2701
Brugia malayi hypothetical protein 0.0374 0.4573 0.513
Echinococcus granulosus acylamino acid releasing enzyme 0.003 0.0213 0.0232
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.024
Echinococcus granulosus caspase 0.0219 0.2601 0.2919
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Toxoplasma gondii ABC1 family protein 0.0071 0.0737 0.1987
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0154
Echinococcus multilocularis protein jagged 1 0.0043 0.0379 0.0373
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0172 0.0065
Brugia malayi calpain 7 0.0146 0.1681 0.1872
Onchocerca volvulus 0.0115 0.1285 0.2588
Toxoplasma gondii hypothetical protein 0.0044 0.0387 0.1019
Echinococcus granulosus apoptotic protease activating factor 1 0.0166 0.1933 0.2167
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0129
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Brugia malayi beta-lactamase 0.0071 0.0737 0.0808
Plasmodium falciparum serine repeat antigen 6 0.0061 0.0601 0.1611
Entamoeba histolytica cysteine proteinase, putative 0.024 0.287 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0413 0.0444
Leishmania major metacaspase, putative 0.0144 0.1655 0.5196
Mycobacterium leprae Probable lipase LipE 0.0071 0.0737 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0216 0.0545
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0083 0.0889 0.2762
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Schistosoma mansoni protein kinase 0.0122 0.1376 0.1528
Trypanosoma brucei oligopeptidase b 0.0068 0.0696 0.215
Onchocerca volvulus 0.0245 0.2935 0.6307
Schistosoma mansoni hypothetical protein 0.0115 0.1285 0.1426
Schistosoma mansoni calmodulin 0.0024 0.0137 0.0133
Trypanosoma brucei Metacaspase-4 0.0144 0.1655 0.5196
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Onchocerca volvulus Huntingtin homolog 0.013 0.148 0.3027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Echinococcus multilocularis neurocalcin 0.0024 0.0137 0.0131
Loa Loa (eye worm) hypothetical protein 0.0167 0.195 0.2192
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0144 0.0394
Schistosoma mansoni cell polarity protein 0.0043 0.0379 0.0405
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0568 0.1743
Onchocerca volvulus 0.0043 0.0379 0.0545
Echinococcus granulosus geminin 0.0166 0.1931 0.2165
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1521 0.1691
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Brugia malayi calcium-binding protein 0.0024 0.0137 0.0133
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0133 0.1521 0.1601
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Echinococcus granulosus intermediate filament protein 0.0029 0.0194 0.0211
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0146 0.1681 0.5279
Giardia lamblia Cathepsin B precursor 0.0263 0.3166 1
Onchocerca volvulus Chorion peroxidase homolog 0.0374 0.4573 1
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.0243
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Onchocerca volvulus Cathepsin L homolog 0.024 0.287 0.616
Plasmodium falciparum importin beta, putative 0.003 0.0216 0.0545
Echinococcus granulosus cathepsin L 0.0061 0.0601 0.0669
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0263 0.3166 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0507 0.057
Plasmodium falciparum cysteine proteinase falcipain 2a 0.024 0.287 0.7894
Echinococcus granulosus cathepsin L cysteine protease 0.0133 0.1521 0.1704
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0601 0.0655
Schistosoma mansoni gabp alpha 0.0072 0.0746 0.0819
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Echinococcus multilocularis calbindin 32 0.0025 0.0143 0.0137
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Onchocerca volvulus 0.0071 0.0737 0.1352
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0568 0.0806
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0411 0.504 0.5656
Plasmodium vivax plasmepsin V, putative 0.0052 0.049 0.1302
Echinococcus multilocularis snurportin 1 0.0324 0.3941 0.3937
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0024 0.0137 0.0026
Echinococcus granulosus cathepsin l1 0.024 0.287 0.3221
Echinococcus granulosus EF HAND 1 calcium binding site 0.0024 0.0137 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0061 0.0601 0.1849
Loa Loa (eye worm) trypsin family protein 0.0115 0.1285 0.1445
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0015 0.002 0.0015
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0024 0.0137 0.0413
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0015
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0026 0.0029
Brugia malayi cathepsin L-like cysteine proteinase 0.0061 0.0601 0.0655
Trypanosoma brucei Calpain-like protein 1.1 0.0044 0.0387 0.1169
Entamoeba histolytica calmodulin, putative 0.0024 0.0137 0.0413
Trypanosoma cruzi calmodulin, putative 0.0024 0.0137 0.0026
Brugia malayi Integrin beta pat-3 precursor 0.0306 0.3712 0.416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0601 0.1849
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Echinococcus granulosus Mastin 0.0115 0.1285 0.1438
Brugia malayi prolyl oligopeptidase family protein 0.0147 0.169 0.1882
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Onchocerca volvulus 0.0052 0.049 0.0794
Mycobacterium ulcerans hypothetical protein 0.0071 0.0737 0.5048
Onchocerca volvulus Prolyl endopeptidase homolog 0.0147 0.169 0.3502
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0061 0.0601 0.1849
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0024 0.0137 0.0133
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0568 0.5
Echinococcus multilocularis musashi 0.0029 0.0194 0.0188
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus multilocularis cathepsin L 0.0061 0.0601 0.0595
Plasmodium vivax aspartyl protease, putative 0.03 0.363 1
Loa Loa (eye worm) fibroinase 0.024 0.287 0.3226
Schistosoma mansoni memapsin-2 (A01 family) 0.0455 0.5593 0.628
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Loa Loa (eye worm) calmodulin-like protein 0.0024 0.0137 0.0154
Leishmania major programmed cell death 6 protein-like protein 0.0024 0.0137 0.0374
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0083 0.0889 0.2762
Brugia malayi Papain family cysteine protease containing protein 0.0133 0.1521 0.1691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0737 0.1113
Echinococcus granulosus neurocalcin 0.0024 0.0137 0.0147
Plasmodium vivax importin-beta 2, putative 0.003 0.0216 0.0545
Leishmania major calmodulin-like protein 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Plasmodium falciparum serine repeat antigen 4 0.0061 0.0601 0.1611
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0025 0.0143 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0034 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0144 0.1655 0.4529
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Echinococcus granulosus neural cadherin 0.0043 0.0379 0.0419
Leishmania major phospholipase c-like protein 0.0024 0.0137 0.0374
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus proteasome prosome macropain 0.0071 0.0734 0.0818
Plasmodium vivax hypothetical protein, conserved 0.003 0.0213 0.0536
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Echinococcus multilocularis neurogenic locus notch protein 4 0.0043 0.0379 0.0373
Schistosoma mansoni protein kinase 0.0122 0.1376 0.1528
Leishmania major calpain protease-like protein 0.0044 0.0387 0.1169
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Echinococcus multilocularis protein jagged 2 0.0043 0.0379 0.0373
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.0379 0.0419
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0115 0.0264
Echinococcus multilocularis acylamino acid releasing enzyme 0.003 0.0213 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0229 0.0236
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Loa Loa (eye worm) hypothetical protein 0.0113 0.1264 0.1422
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.021
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0071 0.0734 0.9953
Loa Loa (eye worm) hypothetical protein 0.0052 0.049 0.0551
Onchocerca volvulus Cathepsin L homolog 0.0061 0.0601 0.1046
Brugia malayi beta-lactamase family protein 0.0071 0.0737 0.0808
Loa Loa (eye worm) hypothetical protein 0.0049 0.0455 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0568 0.1485
Brugia malayi Peroxidasin 0.0374 0.4573 0.513
Onchocerca volvulus Huntingtin homolog 0.013 0.148 0.3027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Schistosoma mansoni reticulocalbin 0.0024 0.0137 0.0133
Toxoplasma gondii preprocathepsin c precursor, putative 0.0061 0.0601 0.1611
Loa Loa (eye worm) integrin beta-2 0.0306 0.3712 0.4173
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0172 0.0193
Leishmania major calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.0379 0.0419
Brugia malayi Cathepsin L-like precursor 0.0073 0.0751 0.0824
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0172 0.0187
Toxoplasma gondii calmodulin CAM1 0.0025 0.0143 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0052 0.049 0.0551
Loa Loa (eye worm) hypothetical protein 0.013 0.148 0.1664
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0071 0.0734 0.2506
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Leishmania major hypothetical protein, conserved 0.0024 0.0137 0.0374
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0178 0.0438
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0394
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Schistosoma mansoni hypothetical protein 0.0032 0.0239 0.0247
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Brugia malayi Importin beta-1 subunit 0.003 0.0216 0.0222
Plasmodium falciparum plasmepsin IX 0.03 0.363 1
Schistosoma mansoni integrin alpha-ps 0.0067 0.0681 0.0745
Echinococcus granulosus lamin dm0 0.0029 0.0194 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0737 0.0708
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Trichomonas vaginalis esterase, putative 0.0071 0.0737 0.2279
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0568 0.0618
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0737 0.0808
Onchocerca volvulus Peroxidase homolog 0.0374 0.4573 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0229 0.0223
Echinococcus granulosus notch 0.0043 0.0379 0.0419
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Echinococcus granulosus calumenin 0.0025 0.0143 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Plasmodium falciparum serine repeat antigen 1 0.0061 0.0601 0.1611
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Leishmania major cysteine peptidase A (CPA) 0.024 0.287 0.9057
Brugia malayi Ets-domain containing protein 0.0072 0.0746 0.0819
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0413 0.0444
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.003 0.0213 0.0536
Entamoeba histolytica hypothetical protein 0.0061 0.0601 0.2041
Schistosoma mansoni caspase-7 (C14 family) 0.031 0.3756 0.421
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0013
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1521 0.1691
Plasmodium falciparum serine repeat antigen 9 0.0061 0.0601 0.1611
Schistosoma mansoni hypothetical protein 0.0024 0.0137 0.0133
Toxoplasma gondii aspartyl protease 0.0052 0.049 0.1302
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus granulosus EF hand domain containing family member A2 0.0024 0.0137 0.0147
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0061 0.0601 0.1611
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0172 0.0165
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0216 0.0625
Onchocerca volvulus Dual oxidase homolog 0.0374 0.4573 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0387 0.4734 0.5312
Loa Loa (eye worm) calpain family protein 1 0.0285 0.3441 0.3868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.1521 0.4771
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0716 0.8895 1
Onchocerca volvulus 0.0115 0.1285 0.2588
Entamoeba histolytica grainin 2 0.0024 0.0137 0.0413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Leishmania major centrin, putative 0.0024 0.0137 0.0374
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0601 0.1594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0044 0.0387 0.1019
Trypanosoma cruzi calmodulin, putative 0.0024 0.0137 0.0026
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0737 0.2279
Schistosoma mansoni laminin gamma-3 chain 0.0043 0.0379 0.0405
Plasmodium vivax vivapain-1 0.0133 0.1521 0.4158
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0167 0.195 0.2192
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.0258
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.0844
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0229 0.0581
Schistosoma mansoni hypothetical protein 0.0115 0.1285 0.1426
Mycobacterium ulcerans lipase LipD 0.0071 0.0737 0.5048
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0122 0.1376 0.1541
Onchocerca volvulus 0.0051 0.0475 0.0762
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0061 0.0601 0.2041
Trypanosoma brucei Calpain-like protein CALP1.3 0.0044 0.0387 0.1169
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) fli-1 protein 0.0219 0.2608 0.2932
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0601 0.1849
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0601 0.1594
Loa Loa (eye worm) cysteine protease 0.024 0.287 0.3226
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Echinococcus multilocularis neuronal calcium sensor 0.0024 0.0137 0.0131
Echinococcus granulosus neurogenic locus notch protein 4 0.0043 0.0379 0.0419
Loa Loa (eye worm) hypothetical protein 0.0052 0.049 0.0551
Trypanosoma brucei calmodulin, putative 0.0025 0.0143 0.0393
Onchocerca volvulus 0.0115 0.1285 0.2588
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0115 0.0108
Plasmodium falciparum serine repeat antigen 7 0.0061 0.0601 0.1611
Echinococcus granulosus importin subunit beta 1 0.003 0.0216 0.0236
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0421 0.0473
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0751 0.0725
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0034 0.0031
Brugia malayi MH2 domain containing protein 0.0016 0.0034 0.0017
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.021
Schistosoma mansoni hypothetical protein 0.0024 0.0137 0.0133
Echinococcus granulosus cathepsin l cysteine peptidase 0.024 0.287 0.3221
Echinococcus multilocularis cathepsin b 0.0716 0.8895 0.8894
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0746 0.0832
Plasmodium falciparum cysteine proteinase falcipain 1 0.0133 0.1521 0.4158
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Echinococcus granulosus slit 2 protein 0.0043 0.0379 0.0419
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0737 0.2279
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0213 0.0322
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.0844
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0194 0.0219
Trypanosoma cruzi cysteine proteinase, putative 0.0133 0.1521 0.1601
Echinococcus multilocularis cathepsin L cysteine protease 0.024 0.287 0.2865
Trichomonas vaginalis centrin, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.0716 0.8895 1
Onchocerca volvulus 0.0028 0.0186 0.0109
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Loa Loa (eye worm) calpain family protein 1 0.0387 0.4734 0.5322
Brugia malayi calpain D 0.0044 0.0387 0.0414
Toxoplasma gondii cathepsin CPC1 0.0061 0.0601 0.1611
Echinococcus granulosus neuronal calcium sensor 0.0024 0.0137 0.0147
Schistosoma mansoni rab 0.0024 0.0137 0.0133
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Schistosoma mansoni ran 0.0022 0.0115 0.0107
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.0379 0.0373
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.0379 0.0405
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0221 0.2635 0.5631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Entamoeba histolytica calcium-binding protein, putative 0.0024 0.0137 0.0413
Giardia lamblia Cathepsin L-like protease 0.0061 0.0601 0.1594
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0737 0.0808
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.003 0.0213 0.0218
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Trichomonas vaginalis calcium binding proteins, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) Smad1 0.0016 0.0034 0.0039
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0061 0.0601 0.0655
Echinococcus multilocularis calpain 7 (C02 family) 0.0146 0.1681 0.1675
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0229 0.0223
Schistosoma mansoni calpain-7 (C02 family) 0.0149 0.1718 0.1913
Echinococcus multilocularis smad 0.0016 0.0034 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Onchocerca volvulus 0.024 0.287 0.616
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0737 0.5048
Loa Loa (eye worm) papain family cysteine protease containing protein 0.024 0.287 0.3226
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Entamoeba histolytica calpain family cysteine protease, putative 0.0044 0.0387 0.1291
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0061 0.0601 0.1611
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0068 0.0696 0.0662
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Onchocerca volvulus 0.024 0.287 0.616
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0052 0.049 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.195 0.6135
Plasmodium falciparum plasmepsin V 0.0052 0.049 0.1302
Echinococcus multilocularis importin subunit beta 1 0.003 0.0216 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi Kelch motif family protein 0.0047 0.0421 0.0452
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Brugia malayi Pre-SET motif family protein 0.0031 0.0229 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0737 0.2279
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0115 0.0302
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0061 0.0601 0.1611
Trypanosoma brucei metacaspase 5, putative 0.0144 0.1655 0.5196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi hypothetical protein 0.0053 0.0507 0.055
Toxoplasma gondii aspartyl protease ASP3 0.03 0.363 1
Brugia malayi prolyl oligopeptidase family protein 0.0083 0.0889 0.0979
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Onchocerca volvulus Slit protein homolog 0.0043 0.0379 0.0545
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0387 0.1169
Trichomonas vaginalis calcineurin B subunit, putative 0.0025 0.0143 0.0393
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0137 0.0374
Loa Loa (eye worm) hypothetical protein 0.031 0.3756 0.4223
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0737 0.1113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0178 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0115 0.1285 0.1426
Trichomonas vaginalis hypothetical protein 0.0044 0.0387 0.1169
Brugia malayi calpain family protein 1 0.0387 0.4734 0.5312
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Mycobacterium tuberculosis Conserved protein 0.0071 0.0737 0.1113
Trichomonas vaginalis centrin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus caspase 3 0.0075 0.0778 0.0867
Onchocerca volvulus Cathepsin F homolog 0.024 0.287 0.616
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0061 0.0601 0.1849
Plasmodium vivax vivapain-2 0.024 0.287 0.7894
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0024 0.0137 0.0374
Echinococcus multilocularis cathepsin b 0.0716 0.8895 0.8894
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Echinococcus multilocularis EF hand domain containing family member A2 0.0025 0.0143 0.0137
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0061 0.0601 0.1611
Trypanosoma cruzi cruzipain precursor, putative 0.024 0.287 0.3137
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0601 0.0676
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Plasmodium falciparum plasmepsin IV 0.0052 0.049 0.1302
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Brugia malayi cathepsin Z-like cysteine proteinase 0.0061 0.0601 0.0655
Echinococcus multilocularis notch 0.0043 0.0379 0.0373
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.003 0.0213 0.0615
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0061 0.0601 0.0676
Giardia lamblia Encystation-specific protease 0.0061 0.0601 0.1594
Plasmodium falciparum serine repeat antigen 3 0.0061 0.0601 0.1611
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Onchocerca volvulus Neurogenic locus notch homolog 0.0043 0.0379 0.0545
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Brugia malayi Blistered cuticle protein 3 0.0374 0.4573 0.513
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0061 0.0601 0.1611
Toxoplasma gondii cathepsin CPC2 0.0061 0.0601 0.1611
Leishmania major hypothetical protein, conserved 0.0025 0.0143 0.0393
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0034 0.0028
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0068 0.0696 0.215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) Notch2 0.0043 0.0379 0.0426
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0568 0.1924
Onchocerca volvulus Putative cubilin 0.0043 0.0379 0.0545
Echinococcus granulosus transmembrane protease serine 3 0.0115 0.1285 0.1438
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Loa Loa (eye worm) calpain D 0.0044 0.0387 0.0436
Echinococcus granulosus tm gpcr rhodopsin 0.0634 0.7857 0.8832
Brugia malayi MH2 domain containing protein 0.0235 0.2808 0.3141
Loa Loa (eye worm) cathepsin B 0.0263 0.3166 0.356
Brugia malayi cathepsin F-like cysteine proteinase 0.0073 0.0751 0.0824
Schistosoma mansoni hypothetical protein 0.0044 0.0387 0.0414
Loa Loa (eye worm) hypothetical protein 0.013 0.148 0.1664
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0221 0.2635 0.263
Schistosoma mansoni calpain (C02 family) 0.0146 0.1681 0.1872
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Leishmania major hypothetical protein, unknown function 0.0044 0.0387 0.1169
Schistosoma mansoni peroxidasin 0.0374 0.4573 0.513
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.1521 0.4771
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0568 0.5
Schistosoma mansoni peroxidasin 0.0374 0.4573 0.513
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0213 0.0218
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0071 0.0734 0.227
Brugia malayi Trypsin family protein 0.0115 0.1285 0.1426
Brugia malayi programmed cell death protein 6 0.0024 0.0137 0.0133
Entamoeba histolytica calpain large subunit domain III containing protein 0.0102 0.1125 0.3878
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Leishmania major calcineurin B subunit, putative 0.0024 0.0137 0.0374
Loa Loa (eye worm) ctsf protein 0.024 0.287 0.3226
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Schistosoma mansoni septate junction protein 0.0043 0.0379 0.0405
Schistosoma mansoni cathepsin C 0.0061 0.0601 0.0655
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Onchocerca volvulus Cathepsin L homolog 0.024 0.287 0.616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Brugia malayi Cadherin domain containing protein 0.0043 0.0379 0.0405
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0144 0.1655 0.1842
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0083 0.0889 0.0883
Mycobacterium ulcerans hypothetical protein 0.0115 0.1285 1
Echinococcus multilocularis Mastin 0.0115 0.1285 0.1279
Schistosoma mansoni Smad4 0.0016 0.0034 0.0017
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0071 0.0734 0.0825
Entamoeba histolytica hypothetical protein, conserved 0.003 0.0213 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0213 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0737 0.0828
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0043 0.0379 0.0545
Trichomonas vaginalis set domain proteins, putative 0.0245 0.2935 0.9264
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Onchocerca volvulus Peroxidasin homolog 0.0374 0.4573 1
Plasmodium vivax unspecified product 0.0073 0.0751 0.2026
Plasmodium falciparum plasmepsin X 0.03 0.363 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0122 0.1376 0.1371
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Giardia lamblia Hypothetical protein 0.0061 0.0601 0.1594
Schistosoma mansoni ap endonuclease 0.0058 0.0568 0.0618
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0751 0.0844
Echinococcus multilocularis transmembrane protease serine 3 0.0115 0.1285 0.1279
Entamoeba histolytica cysteine proteinase, putative 0.024 0.287 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0172 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Schistosoma mansoni smad 0.0016 0.0034 0.0017
Leishmania major importin beta-1 subunit, putative 0.0025 0.0144 0.0394
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0115 0.0107
Plasmodium vivax unspecified product 0.0133 0.1521 0.4158
Schistosoma mansoni hypothetical protein 0.0398 0.4873 0.5468
Onchocerca volvulus 0.024 0.287 0.616
Schistosoma mansoni calmodulin 0.0024 0.0137 0.0133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0413 0.0458
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0213 0.0615
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0061 0.0601 0.1594
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Plasmodium vivax unspecified product 0.0061 0.0601 0.1611
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.0016 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.5615 1
Onchocerca volvulus 0.024 0.287 0.616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Schistosoma mansoni centrin-related 0.0024 0.0137 0.0133
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0071 0.0734 0.0805
Trichomonas vaginalis myosin light chain 1, putative 0.0024 0.0137 0.0374
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0061 0.0601 0.0655
Schistosoma mansoni calpain-2 (C02 family) 0.0044 0.0387 0.0414
Trypanosoma brucei calpain, putative 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0068 0.0696 0.9337
Brugia malayi MH1 domain containing protein 0.0016 0.0034 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0194 0.0219
Plasmodium falciparum metacaspase-like protein 0.0144 0.1655 0.4529
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0172 0.0534
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0213 0.0679
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0751 0.0725
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0413 0.0444
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0024 0.0137 0.0374
Plasmodium falciparum plasmepsin I 0.0052 0.049 0.1302
Echinococcus granulosus calcium uptake protein 1 0.0025 0.0143 0.0154
Echinococcus multilocularis calpain A 0.0412 0.5046 0.5042
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0172 0.0422
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.0379 0.0373
Trichomonas vaginalis calcineurin B subunit, putative 0.0024 0.0137 0.0374
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Onchocerca volvulus 0.0031 0.0229 0.0208
Trypanosoma cruzi oligopeptidase b 0.0068 0.0696 0.0662
Echinococcus granulosus flap endonuclease 1 0.0027 0.0172 0.0186
Trypanosoma brucei cysteine peptidase, putative 0.0044 0.0387 0.1169
Leishmania major hypothetical protein, conserved 0.0044 0.0387 0.1169
Echinococcus multilocularis cpg binding protein 0.003 0.0206 0.0199
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0455 0.049
Brugia malayi Cathepsin L-like cysteine proteinase 0.0167 0.195 0.2175
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0083 0.0889 0.0882
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.1655 0.4529
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Brugia malayi Cathepsin L-like precursor 0.0167 0.195 0.2175
Toxoplasma gondii troponin c, isotype gamma, putative 0.0024 0.0137 0.0326
Echinococcus multilocularis hypothetical protein 0.0146 0.1681 0.1675
Leishmania major centrin, putative 0.0024 0.0137 0.0374
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0024 0.0137 0.0026
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0379 0.0405
Echinococcus granulosus EF hand domain containing family member A2 0.0025 0.0143 0.0154
Echinococcus granulosus calpain 5 0.0146 0.1681 0.1884
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Brugia malayi Cell death protein 3 precursor 0.031 0.3756 0.421
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Brugia malayi Papain family cysteine protease containing protein 0.024 0.287 0.3211
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Echinococcus granulosus peroxidasin 0.0374 0.4573 0.5137
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0411 0.504 0.5036
Echinococcus granulosus centrin 2 0.0024 0.0137 0.0147
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0503
Schistosoma mansoni cathepsin S (C01 family) 0.0061 0.0601 0.0655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0062 0.0613 0.069
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0147 0.169 0.1882
Schistosoma mansoni ets-related 0.0219 0.2608 0.2917
Schistosoma mansoni hypothetical protein 0.0051 0.0475 0.0514
Trichomonas vaginalis calpain, putative 0.0044 0.0387 0.1169
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0229 0.0236
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4873 0.487
Trypanosoma brucei metacaspase MCA3 0.0144 0.1655 0.5196
Trypanosoma cruzi kinesin, putative 0.0102 0.1125 0.115
Plasmodium falciparum serine repeat antigen 2 0.0061 0.0601 0.1611
Schistosoma mansoni calpain C (C02 family) 0.0146 0.1681 0.1872
Giardia lamblia High cysteine protein 0.0043 0.0379 0.0866
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0068 0.0696 0.215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0147 0.169 0.531
Loa Loa (eye worm) hypothetical protein 0.0027 0.0178 0.02
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Echinococcus multilocularis proteasome (prosome, macropain) 0.0071 0.0734 0.0728
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0061 0.0601 0.1594
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Brugia malayi prolyl oligopeptidase family protein 0.0221 0.2635 0.2947
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.002 0.0013
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0172 0.0484
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0061 0.0601 0.1849
Echinococcus multilocularis calpain 5 0.0146 0.1681 0.1675
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0413 0.0458
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Brugia malayi hypothetical protein 0.0052 0.049 0.053
Schistosoma mansoni neuronal calcium sensor 0.0024 0.0137 0.0133
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Entamoeba histolytica cysteine proteinase 2 0.0133 0.1521 0.5268
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655
Schistosoma mansoni hypothetical protein 0.0166 0.1933 0.2156
Entamoeba histolytica Ran family GTPase 0.0022 0.0115 0.0334
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0068 0.0696 0.104
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0737 0.2279
Toxoplasma gondii EF hand domain-containing protein 0.0024 0.0137 0.0326
Onchocerca volvulus 0.024 0.287 0.616
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0601 0.0554
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0061 0.0601 0.1611
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0601 0.1849
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0115 0.0264
Onchocerca volvulus Cell death protein 3 homolog 0.031 0.3756 0.8159
Onchocerca volvulus 0.0166 0.1933 0.4048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Trypanosoma cruzi conserved protein 0.0044 0.0387 0.0311
Onchocerca volvulus 0.0043 0.0379 0.0545
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0044 0.0387 0.0311
Onchocerca volvulus 0.0241 0.2885 0.6194
Brugia malayi Papain family cysteine protease containing protein 0.0133 0.1521 0.1691
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0061 0.0601 0.0655
Plasmodium vivax aspartyl proteinase, putative 0.0052 0.049 0.1302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0413 0.0407
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0734 0.0705
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0219 0.2601 0.2919
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0503
Brugia malayi EF hand family protein 0.0025 0.0143 0.0139
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Echinococcus multilocularis Smad4 0.0016 0.0034 0.0028
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0107 0.1188 0.1317
Echinococcus granulosus integrin beta 2 0.0227 0.2706 0.3037
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.1169
Trypanosoma cruzi metacaspase 5, putative 0.0144 0.1655 0.1754
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0601 0.0655
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0737 0.2279
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.024 0.287 0.9057
Giardia lamblia Hypothetical protein 0.0061 0.0601 0.1594
Brugia malayi hypothetical protein 0.0249 0.2988 0.3345
Brugia malayi RNA, U transporter 1 0.0086 0.0926 0.1021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Echinococcus multilocularis calmodulin 0.0024 0.0137 0.0131
Brugia malayi EF hand family protein 0.0024 0.0137 0.0133
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0387 0.0311
Echinococcus multilocularis programmed cell death protein 0.0024 0.0137 0.0131
Loa Loa (eye worm) hypothetical protein 0.0241 0.2885 0.3243
Echinococcus granulosus cathepsin l1 0.0167 0.195 0.2186
Brugia malayi GCC2 and GCC3 family protein 0.0043 0.0379 0.0405
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.0435
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0737 0.1113
Echinococcus granulosus protein jagged 1 0.0043 0.0379 0.0419
Echinococcus granulosus neurogenic locus protein delta 0.0043 0.0379 0.0419
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Schistosoma mansoni protein kinase 0.0122 0.1376 0.1528
Trypanosoma cruzi I/6 autoantigen, putative 0.0024 0.0137 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1426
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0083 0.0889 0.2408
Toxoplasma gondii proteasome subunit beta type, putative 0.0071 0.0734 0.1979
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0052 0.049 0.1494
Brugia malayi hypothetical protein 0.013 0.148 0.1645
Trichomonas vaginalis ran, putative 0.0022 0.0115 0.0302
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0034 0.0031
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Schistosoma mansoni cathepsin D (A01 family) 0.0341 0.4154 0.4658
Echinococcus multilocularis glycoprotein Antigen 5 0.0115 0.1285 0.1279
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0216 0.0625
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.195 0.6773
Loa Loa (eye worm) blistered cuticle protein 3 0.0374 0.4573 0.5141
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Brugia malayi Pepsin A precursor 0.0052 0.049 0.053
Leishmania major centrin, putative,caltractin, putative 0.0024 0.0137 0.0374
Trypanosoma cruzi metacaspase 5, putative 0.0144 0.1655 0.1754
Echinococcus multilocularis cysteine protease 0.024 0.287 0.2865
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0068 0.0696 0.4682
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma brucei centrin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus smad 0.0016 0.0034 0.0031
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Plasmodium vivax SET domain protein, putative 0.0031 0.0229 0.0581
Brugia malayi Muscle positioning protein 4 0.0043 0.0379 0.0405
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0061 0.0601 0.1611
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0568 0.0562
Mycobacterium tuberculosis Probable peptidase 0.0068 0.0696 0.104
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0172 0.0484
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.0844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Mycobacterium ulcerans proteasome PrcB 0.0071 0.0734 0.5022
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0213 0.0322
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Schistosoma mansoni ap endonuclease 0.0058 0.0568 0.0618
Schistosoma mansoni centrin 0.0024 0.0137 0.0133
Entamoeba histolytica calmodulin, putative 0.0024 0.0137 0.0413
Trypanosoma brucei Calpain-like protein 1.2 0.0044 0.0387 0.1169
Brugia malayi Angiotensin-converting enzyme family protein 0.0607 0.752 0.8451
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0135 0.0367
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.1655 0.4529
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0072
Echinococcus granulosus cathepsin L 0.0133 0.1521 0.1704
Echinococcus granulosus Dipeptidyl peptidase 9 0.0083 0.0889 0.0993
Trypanosoma brucei kinesin, putative 0.0102 0.1125 0.3512
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0263 0.3166 1
Onchocerca volvulus 0.0043 0.0379 0.0545
Plasmodium vivax proteasome subunit beta type-5, putative 0.0071 0.0734 0.1979
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0413 0.0465
Loa Loa (eye worm) hypothetical protein 0.0028 0.0188 0.0211
Entamoeba histolytica grainin, putative 0.0025 0.0143 0.0434
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Brugia malayi Pre-SET motif family protein 0.0215 0.2559 0.2861
Entamoeba histolytica cysteine protease, putative 0.0061 0.0601 0.2041
Schistosoma mansoni cathepsin B (C01 family) 0.0061 0.0601 0.0655
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0034 0.0039
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0221 0.2635 0.2947
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0379 0.0405
Toxoplasma gondii EFHC1, putative 0.0024 0.0137 0.0326
Echinococcus multilocularis calpain 0.0146 0.1681 0.1675
Brugia malayi cathepsin B-like cysteine proteinase 0.0716 0.8895 1
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0024 0.0137 0.0413
Echinococcus multilocularis enteropeptidase 0.0115 0.1285 0.1279
Leishmania major proteasome beta 5 subunit, putative 0.0071 0.0734 0.227
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Brugia malayi beta-lactamase family protein 0.0071 0.0737 0.0808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0568 0.1519
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0601 0.0676
Onchocerca volvulus 0.0071 0.0737 0.1352
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0061 0.0601 0.1611
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0133 0.1521 0.1691
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0213 0.0218
Trichomonas vaginalis calmodulin, putative 0.0025 0.0143 0.0393
Echinococcus granulosus calmodulin 0.0024 0.0137 0.0147
Echinococcus granulosus calpain A 0.0412 0.5046 0.5669
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0083 0.0889 0.0882
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Trypanosoma cruzi cysteine peptidase, putative 0.024 0.287 0.3137
Schistosoma mansoni hypothetical protein 0.0166 0.1931 0.2153
Brugia malayi calpain 5 0.0044 0.0387 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Trypanosoma brucei I/6 autoantigen 0.0024 0.0137 0.0374
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0024 0.0137 0.0131
Echinococcus multilocularis caspase 8 0.0144 0.1655 0.1649
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Leishmania major calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus multilocularis caspase 2 0.031 0.3756 0.3752
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0044 0.0387 0.1169
Entamoeba histolytica protein kinase, putative 0.0102 0.1129 0.3891
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0137 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Echinococcus granulosus fibropellin Ia 0.0043 0.0379 0.0419
Trypanosoma cruzi prolyl endopeptidase 0.0147 0.169 0.1794
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0263 0.3166 0.3476
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0146 0.1681 0.1784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.1521 0.4771
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0229 0.0251
Trypanosoma cruzi metacaspase, putative 0.0144 0.1655 0.1754
Plasmodium vivax metacaspase 1, putative 0.0144 0.1655 0.4529
Entamoeba histolytica hypothetical protein 0.0027 0.0178 0.0555
Toxoplasma gondii cathepsin CPL 0.024 0.287 0.7894
Brugia malayi Ets-domain containing protein 0.0072 0.0746 0.0819
Trypanosoma brucei calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus multilocularis lamin dm0 0.0029 0.0194 0.0188
Echinococcus granulosus calbindin 32 0.0025 0.0143 0.0154
Loa Loa (eye worm) hypothetical protein 0.0387 0.4734 0.5322
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0052 0.049 0.1302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Toxoplasma gondii exonuclease III APE 0.0058 0.0568 0.1519
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0207 0.0226
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0178 0.0438
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0115 0.0122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0568 0.1743
Echinococcus granulosus Smad4 0.0016 0.0034 0.0031
Brugia malayi hypothetical protein 0.0166 0.1933 0.2156
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.049 0.053
Giardia lamblia Cathepsin B precursor 0.0061 0.0601 0.1594
Brugia malayi calpain family protein 1 0.0387 0.4734 0.5312
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0073 0.0751 0.0824
Leishmania major oligopeptidase b 0.0068 0.0696 0.215
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0634 0.7857 0.7856
Trypanosoma brucei centrin-3 0.0024 0.0137 0.0374
Brugia malayi calpain 5 0.0102 0.1125 0.1245
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0178 0.0503
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0186 0.0209
Brugia malayi intermediate filament protein 0.0029 0.0194 0.0197
Echinococcus multilocularis cathepsin l cysteine peptidase 0.024 0.287 0.2865
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0052 0.049 0.1302
Onchocerca volvulus 0.0115 0.1285 0.2588
Onchocerca volvulus 0.024 0.287 0.616
Loa Loa (eye worm) calpain 5 0.0102 0.1125 0.1265
Echinococcus granulosus tumor protein p63 0.0336 0.4091 0.4595
Plasmodium vivax serine-repeat antigen (SERA) 0.0061 0.0601 0.1611
Plasmodium falciparum cysteine proteinase falcipain 3 0.024 0.287 0.7894
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Leishmania major GTP-binding protein, putative 0.0022 0.0115 0.0302
Echinococcus multilocularis integrin alpha ps 0.0067 0.0681 0.0675
Loa Loa (eye worm) hypothetical protein 0.0032 0.0239 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Echinococcus granulosus integrin alpha ps 0.0032 0.0239 0.0261
Loa Loa (eye worm) hypothetical protein 0.0374 0.4573 0.5141
Schistosoma mansoni cathepsin F (C01 family) 0.0167 0.195 0.2175
Loa Loa (eye worm) hypothetical protein 0.0249 0.2988 0.3359
Giardia lamblia Hypothetical protein 0.0025 0.0143 0.0093
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Echinococcus multilocularis geminin 0.0166 0.1931 0.1925
Trypanosoma cruzi centrin-3 0.0024 0.0137 0.0026
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0024 0.0141 0.0386
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0737 0.1113
Echinococcus granulosus protein jagged 1 0.0043 0.0379 0.0419
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0213 0.0218
Onchocerca volvulus 0.0374 0.4573 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2988 0.3354
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.2752 0.3094
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0024 0.0137 0.0131
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.1655 0.5196
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0022
Loa Loa (eye worm) animal heme peroxidase 0.0374 0.4573 0.5141
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2988 0.2984
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0068 0.0696 0.0662
Onchocerca volvulus 0.0167 0.195 0.4087
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Brugia malayi hypothetical protein 0.0047 0.0421 0.0452
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Giardia lamblia Cathepsin B precursor 0.0263 0.3166 1
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0568 0.1743
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0517 0.1376
Giardia lamblia Cysteine protease 0.0061 0.0601 0.1594
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.0311
Onchocerca volvulus 0.0052 0.049 0.0794
Schistosoma mansoni intermediate filament proteins 0.0029 0.0194 0.0197
Echinococcus multilocularis tyrosine protein kinase shark 0.0256 0.3079 0.3075
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.1784
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0178 0.0438
Brugia malayi Cathepsin L-like precursor 0.024 0.287 0.3211
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Onchocerca volvulus 0.0115 0.1285 0.2588
Brugia malayi Cathepsin L-like precursor 0.0167 0.195 0.2175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.195 0.6135
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0052 0.049 0.0551
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0229 0.0236
Plasmodium vivax vivapain-3 0.0133 0.1521 0.4158
Loa Loa (eye worm) hypothetical protein 0.0083 0.0877 0.0986
Leishmania major kinesin, putative 0.0102 0.1125 0.3512
Loa Loa (eye worm) prolyl oligopeptidase 0.0221 0.2635 0.2962
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Plasmodium falciparum plasmepsin VII 0.0052 0.049 0.1302
Loa Loa (eye worm) hypothetical protein 0.0343 0.4178 0.4697
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0737 0.1113
Trypanosoma cruzi I/6 autoantigen, putative 0.0024 0.0137 0.0026
Plasmodium falciparum flap endonuclease 1 0.0027 0.0172 0.0422
Plasmodium vivax aspartyl protease, putative 0.03 0.363 1
Plasmodium vivax calpain, putative 0.0146 0.1681 0.4601
Echinococcus granulosus programmed cell death protein 0.0024 0.0137 0.0147
Onchocerca volvulus 0.0071 0.0737 0.1352
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.0379 0.0373
Echinococcus granulosus cpg binding protein 0.003 0.0206 0.0224
Trypanosoma cruzi centrin, putative 0.0024 0.0137 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0213 0.0112
Trypanosoma brucei hypothetical protein 0.0044 0.0387 0.1169
Schistosoma mansoni tyrosine kinase 0.0256 0.3079 0.3447
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Brugia malayi fibroinase precursor 0.0061 0.0601 0.0655
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0379 0.0405
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0178 0.0854
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0083 0.0889 0.2762
Plasmodium vivax serine-repeat antigen (SERA) 0.0061 0.0601 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.024 0.287 0.9057
Trypanosoma brucei mitochondrial calcium uptake 1 0.0024 0.0137 0.0374
Schistosoma mansoni notch 0.0043 0.0379 0.0405
Trypanosoma brucei antigen, putative 0.0146 0.1681 0.5279
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Echinococcus granulosus protein jagged 2 0.0043 0.0379 0.0419
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0178 0.0171
Loa Loa (eye worm) hypothetical protein 0.0061 0.0601 0.0676
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0017
Loa Loa (eye worm) programmed cell death protein 6 0.0025 0.0143 0.0161
Toxoplasma gondii cathepsin B 0.0263 0.3166 0.8717
Brugia malayi Smad1 0.0016 0.0034 0.0017
Plasmodium falciparum centrin-1 0.0024 0.0137 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0061 0.0601 0.1849
Entamoeba histolytica calcium binding family protein 0.0024 0.0137 0.0413
Loa Loa (eye worm) hypothetical protein 0.0115 0.1285 0.1445
Brugia malayi cathepsin L-like precursor 0.0167 0.195 0.2175
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0411 0.504 0.5656
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0061 0.0601 0.1611
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.1309 0.2155
Loa Loa (eye worm) hypothetical protein 0.0117 0.1319 0.1483
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0071 0.0734 0.227
Echinococcus multilocularis prolyl endopeptidase 0.0147 0.169 0.1685
Schistosoma mansoni smad1 5 8 and 0.0016 0.0034 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0737 0.5048
Echinococcus granulosus protein jagged 2 0.0043 0.0379 0.0419
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0143 0.0342
Loa Loa (eye worm) hypothetical protein 0.0147 0.169 0.19
Trypanosoma cruzi caltractin, putative 0.0024 0.0137 0.0026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0716 0.8895 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0737 0.0708
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0107 0.1188 0.1336
Onchocerca volvulus 0.024 0.287 0.616
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.1726 0.1923
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.1521 0.1601
Echinococcus multilocularis fat cadherin tumor suppressor 0.0043 0.0379 0.0373
Toxoplasma gondii aspartyl protease ASP1 0.0052 0.049 0.1302
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.2808 0.3156
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0194 0.0197
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Trypanosoma brucei prolyl endopeptidase 0.0147 0.169 0.531
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0071 0.0734 0.2029
Trypanosoma brucei calpain-like protein, putative 0.0146 0.1681 0.5279
Trichomonas vaginalis calpain, putative 0.0044 0.0387 0.1169
Onchocerca volvulus 0.0029 0.0194 0.0129
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0115 0.1285 0.1279
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0213 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Brugia malayi cathepsin L precursor 0.0061 0.0601 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.1655 0.5196
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0716 0.8895 1
Schistosoma mansoni hypothetical protein 0.0324 0.3941 0.4418
Plasmodium falciparum plasmepsin III 0.0052 0.049 0.1302
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0737 1
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0178 0.0206
Echinococcus granulosus enteropeptidase 0.0115 0.1285 0.1438
Schistosoma mansoni calpain-7 (C02 family) 0.0149 0.1718 0.1913
Toxoplasma gondii centrin 0.0024 0.0137 0.0326
Schistosoma mansoni integrin beta subunit 0.018 0.2116 0.2362
Brugia malayi Delta serrate ligand family protein 0.0043 0.0379 0.0405
Toxoplasma gondii centrin, putative 0.0024 0.0137 0.0326
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0043 0.0379 0.0405
Leishmania major cathepsin L-like protease 0.024 0.287 0.9057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.024 0.287 0.9057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0601 0.1849
Trypanosoma brucei Calpain-like protein 2 0.0044 0.0387 0.1169
Echinococcus multilocularis calumenin 0.0025 0.0143 0.0137
Schistosoma mansoni cathepsin D (A01 family) 0.0341 0.4154 0.4658
Loa Loa (eye worm) hypothetical protein 0.0071 0.0737 0.0828
Brugia malayi Cadherin domain containing protein 0.0043 0.0379 0.0405
Trypanosoma cruzi cysteine proteinase, putative 0.0133 0.1521 0.1601
Echinococcus granulosus cysteine protease 0.0133 0.1521 0.1704
Loa Loa (eye worm) hypothetical protein 0.0052 0.049 0.0551
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0115 0.1285 0.1438
Echinococcus granulosus integrin alpha ps 0.0067 0.0681 0.0758
Plasmodium falciparum peptidase, putative 0.003 0.0213 0.0536
Brugia malayi notch-like transmembrane receptor 0.0043 0.0379 0.0405
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Trichomonas vaginalis calmodulin, putative 0.0024 0.0137 0.0374
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0325 0.0847
Trypanosoma brucei cysteine peptidase C (CPC) 0.0263 0.3166 1
Echinococcus granulosus integrin alpha 3 0.0115 0.1284 0.1437
Entamoeba histolytica cysteine proteinase, putative 0.0133 0.1521 0.5268
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Brugia malayi EGF-like domain containing protein 0.0043 0.0379 0.0405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0568 0.0516
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0146 0.1681 0.5279
Echinococcus granulosus tyrosine protein kinase shark 0.0256 0.3079 0.3457
Loa Loa (eye worm) calpain 0.0146 0.1681 0.189
Brugia malayi Eukaryotic aspartyl protease family protein 0.0052 0.049 0.053
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.1285 0.1426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.024 0.287 0.9057
Schistosoma mansoni importin beta-1 0.003 0.0216 0.0222
Echinococcus multilocularis cathepsin L 0.0133 0.1521 0.1515
Trypanosoma cruzi calmodulin, putative 0.0024 0.0137 0.0026
Trypanosoma brucei protein I/6 0.0024 0.0137 0.0374
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0147 0.169 0.1882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0601 0.1849
Onchocerca volvulus 0.0049 0.0455 0.0716
Echinococcus multilocularis lamin 0.0029 0.0194 0.0188
Brugia malayi aspartic protease BmAsp-1, identical 0.0052 0.049 0.053
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0115 0.1285 0.1279
Echinococcus multilocularis caspase 3 0.0075 0.0778 0.0771
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0015 0.002 0.0022
Plasmodium vivax centrin-1, putative 0.0024 0.0137 0.0326
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.0311
Schistosoma mansoni ran 0.0022 0.0115 0.0107
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.2808 0.3156
Trypanosoma brucei prolyl oligopeptidase, putative 0.0068 0.0696 0.215
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0015 0.002 0.0022
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0746 0.0839
Trypanosoma cruzi kinesin, putative 0.0102 0.1125 0.115
Mycobacterium ulcerans beta-lactamase 0.0071 0.0737 0.5048
Entamoeba histolytica cysteine protease, putative 0.0133 0.1521 0.5268
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Leishmania major calmodulin-like protein 0.0024 0.0137 0.0374
Echinococcus multilocularis cysteine protease 0.024 0.287 0.2865
Toxoplasma gondii hypothetical protein 0.003 0.0213 0.0536
Toxoplasma gondii prolyl endopeptidase 0.0147 0.169 0.4628
Onchocerca volvulus Peroxidasin homolog 0.0374 0.4573 1
Schistosoma mansoni caspase-7 (C14 family) 0.0219 0.2601 0.2908
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0387 0.1169
Echinococcus granulosus cathepsin b 0.0716 0.8895 1
Trypanosoma cruzi centrin, putative 0.0024 0.0137 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0601 0.1849
Echinococcus multilocularis calcium uptake protein 1 0.0025 0.0143 0.0137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0154
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0024 0.0137 0.0147
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0061 0.0601 0.2041
Brugia malayi Animal haem peroxidase family protein 0.0374 0.4573 0.513
Onchocerca volvulus 0.0025 0.0143 0.0013
Brugia malayi Fli-1 protein 0.0219 0.2608 0.2917
Loa Loa (eye worm) hypothetical protein 0.0166 0.1933 0.2173
Loa Loa (eye worm) hypothetical protein 0.0167 0.195 0.2192
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0213 0.0679
Trichomonas vaginalis calcium binding protein, putative 0.0024 0.0137 0.0374
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0178 0.0178
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0213 0.0679
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Schistosoma mansoni hypothetical protein 0.0043 0.0379 0.0405
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0737 0.1113
Schistosoma mansoni integrin alpha-ps 0.0035 0.0274 0.0286
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0194 0.0219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0229 0.0236
Entamoeba histolytica cysteine protease, putative 0.024 0.287 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0133 0.1521 0.4771
Onchocerca volvulus 0.0374 0.4573 1
Brugia malayi Trypsin-like protease protein 5 0.0115 0.1285 0.1426
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0737 0.1987
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0426
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.1264 0.1403
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0044 0.0387 0.0311
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0024 0.0141 0.003
Echinococcus multilocularis calmodulin 0.0024 0.0137 0.0131
Onchocerca volvulus 0.0029 0.0194 0.0129
Giardia lamblia Cathepsin L precursor 0.0061 0.0601 0.1594
Loa Loa (eye worm) notch protein 0.0043 0.0379 0.0426
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0061 0.0601 0.0655

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 73 % Agonist activity at human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay relative to DPDPE ChEMBL. 24973818
EC50 (functional) = 2.37 nM Agonist activity at human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay ChEMBL. 24973818
Ke (functional) = 29.3 nM Antagonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes assessed as inhibition of U69593-induced response after 60 mins by [35S]GTPgammaS binding assay ChEMBL. 24973818
Ke (functional) = 32.9 nM Antagonist activity at human recombinant mu opioid receptor expressed in CHO cell membranes assessed as inhibition of DAMGO-induced response after 60 mins by [35S]GTPgammaS binding assay ChEMBL. 24973818
Ki (binding) = 1.02 nM Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method ChEMBL. 24973818
Ki (binding) = 2.03 nM Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method ChEMBL. 24973818
Ki (binding) = 4.68 nM Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method ChEMBL. 24973818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.