Detailed information for compound 115138

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 517.626 | Formula: C27H35N9O2
  • H donors: 3 H acceptors: 2 LogP: 4.5 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#CN/C(=N\CCCNC(=O)c1ccc(cc1)N=[N+]=[N-])/NCCCOc1cccc(c1)CN1CCCCC1
  • InChi: 1S/C27H35N9O2/c28-21-33-27(31-14-5-13-30-26(37)23-9-11-24(12-10-23)34-35-29)32-15-6-18-38-25-8-4-7-22(19-25)20-36-16-2-1-3-17-36/h4,7-12,19H,1-3,5-6,13-18,20H2,(H,30,37)(H2,31,32,33)
  • InChiKey: XNBHITOPLOGDRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0054 0.0054
Trypanosoma brucei centrin-3 0.0198 0.043 0.1229
Entamoeba histolytica hypothetical protein 0.0039 0.0054 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0011 0.0011
Echinococcus multilocularis GPI anchor transamidase 0.0035 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Entamoeba histolytica cysteine proteinase 2 0.0478 0.1093 0.5551
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.019 0.0413 0.0413
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0011 0.0011
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0501 0.1149 0.1149
Brugia malayi prolyl oligopeptidase family protein 0.1494 0.3501 0.3501
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0011 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.4239 1 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0081 0.0154 0.0154
Onchocerca volvulus 0.0179 0.0387 0.0823
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1195 0.2792 0.2792
Echinococcus multilocularis cathepsin L 0.0478 0.1093 0.1093
Loa Loa (eye worm) prolyl oligopeptidase 0.0501 0.1149 0.1149
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Entamoeba histolytica GPI-anchor transamidase, putative 0.0035 0.0045 0.0227
Trypanosoma brucei prolyl oligopeptidase, putative 0.0611 0.1409 0.4024
Onchocerca volvulus 0.019 0.0413 0.0878
Trichomonas vaginalis calmodulin, putative 0.019 0.0413 0.1187
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0054 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0017
Brugia malayi CXXC zinc finger family protein 0.0028 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0011 0.0011
Echinococcus granulosus calcium uptake protein 1 0.0193 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0555 0.1597
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0079
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.025 0.0555 0.1988
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1195 0.2792 0.2792
Mycobacterium ulcerans hypothetical protein 0.0038 0.0052 0.0366
Brugia malayi cathepsin F-like cysteine proteinase 0.025 0.0555 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0811 0.1883 0.5417
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0034 0.0097
Loa Loa (eye worm) beta-lactamase 0.0038 0.0052 0.0052
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0009 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0011 0.0011
Brugia malayi cathepsin L-like cysteine proteinase 0.025 0.0555 0.0555
Schistosoma mansoni hypothetical protein 0.0179 0.0387 0.0387
Trichomonas vaginalis set domain proteins, putative 0.0476 0.1089 0.3134
Trypanosoma cruzi cysteine peptidase, putative 0.0811 0.1883 0.1883
Schistosoma mansoni hypothetical protein 0.0083 0.0159 0.0159
Entamoeba histolytica cysteine protease, putative 0.025 0.0555 0.2818
Leishmania major calpain family cysteine protease-like protein 0.0347 0.0785 0.2242
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0035 0.0044 0.0044
Plasmodium falciparum calpain 0.0347 0.0785 0.4168
Trypanosoma cruzi cysteine peptidase, putative 0.0906 0.2108 0.2108
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.015 0.0317 0.0913
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.025 0.0555 0.0555
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0039 0.0055 0.0156
Echinococcus granulosus caspase 0.0018 0.0004 0.0004
Plasmodium falciparum serine repeat antigen 3 0.025 0.0555 0.2947
Trichomonas vaginalis esterase, putative 0.0038 0.0052 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Giardia lamblia Cathepsin B precursor 0.025 0.0555 0.1597
Plasmodium vivax proteasome subunit beta type-2, putative 0.0039 0.0055 0.0196
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0054 0.0054
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.025 0.0555 0.2947
Leishmania major i/6 autoantigen-like protein 0.019 0.0413 0.1179
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0054 0.0054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.019 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0555 0.1597
Plasmodium vivax unspecified product 0.0227 0.0501 0.1793
Plasmodium falciparum plasmepsin X 0.0017 0.0002 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0584 0.1345 0.1345
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0106 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.025 0.0555 0.0555
Brugia malayi Trypsin family protein 0.0083 0.0159 0.0159
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0002 0.0002
Echinococcus multilocularis cpg binding protein 0.003 0.0032 0.0032
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.025 0.0555 0.1597
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0083 0.0159 0.0159
Giardia lamblia Cysteine protease 0.025 0.0555 0.1597
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.1093 0.5551
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0054 0.0054
Brugia malayi Papain family cysteine protease containing protein 0.0478 0.1093 0.1093
Brugia malayi Trypsin family protein 0.0083 0.0159 0.0159
Plasmodium vivax hypothetical protein, conserved 0.0193 0.042 0.1505
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0011 0.0011
Schistosoma mansoni calpain-7 (C02 family) 0.1195 0.2792 0.2792
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4239 1 1
Echinococcus granulosus calmodulin 0.019 0.0413 0.0413
Brugia malayi calpain 5 0.0347 0.0785 0.0785
Giardia lamblia Encystation-specific protease 0.025 0.0555 0.1597
Brugia malayi Cytochrome P450 family protein 0.0032 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0179 0.0387 0.0387
Schistosoma mansoni cpg binding protein 0.0028 0.0029 0.0029
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0054 0.0054
Plasmodium falciparum serine repeat antigen 5 0.025 0.0555 0.2947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.1093 0.3145
Echinococcus granulosus dnaJ subfamily B 0.0399 0.0907 0.0907
Loa Loa (eye worm) programmed cell death protein 6 0.0193 0.042 0.042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0052 0.0052
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0034 0.0096
Echinococcus granulosus cathepsin l1 0.0584 0.1345 0.1345
Toxoplasma gondii centrin 0.019 0.0413 0.1179
Onchocerca volvulus 0.0038 0.0052 0.011
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0159
Entamoeba histolytica cysteine protease, putative 0.025 0.0555 0.2818
Trypanosoma brucei calpain, putative 0.0347 0.0785 0.2242
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0271 0.0603 0.1723
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0054 0.0054
Echinococcus granulosus FTZ F1 alpha 0.002 0.0011 0.0011
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0081 0.0154 0.0154
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.019 0.0413 0.1179
Schistosoma mansoni Mername-AA248 (C02 family) 0.1195 0.2792 0.2792
Schistosoma mansoni cathepsin F (C01 family) 0.0811 0.1883 0.1883
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0811 0.1883 0.1883
Loa Loa (eye worm) prolyl oligopeptidase 0.0181 0.0392 0.0392
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0011 0.0011
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0054 0.0054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0478 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.3197 0.7531 0.7531
Trichomonas vaginalis centrin, putative 0.019 0.0413 0.1187
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0006 1
Giardia lamblia Cathepsin L precursor 0.025 0.0555 0.1597
Schistosoma mansoni caspase-7 (C14 family) 0.0154 0.0327 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Plasmodium falciparum plasmepsin III 0.0017 0.0002 0.0012
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.002 0.0009 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Onchocerca volvulus 0.0151 0.032 0.068
Brugia malayi hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) proteasome subunit beta type 2 0.0039 0.0055 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0011 0.0011
Toxoplasma gondii exonuclease III APE 0.0018 0.0006 0.0016
Entamoeba histolytica calpain family cysteine protease, putative 0.0347 0.0785 0.3985
Loa Loa (eye worm) calpain D 0.0347 0.0785 0.0785
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0611 0.1409 0.1409
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0555 0.1597
Trichomonas vaginalis calcium binding protein, putative 0.0198 0.043 0.1238
Echinococcus granulosus cathepsin b 0.4239 1 1
Brugia malayi Pre-SET motif family protein 0.0418 0.0953 0.0953
Schistosoma mansoni nuclear hormone receptor 0.002 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0039 0.0054 0.0274
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Leishmania major centrin, putative,caltractin, putative 0.019 0.0413 0.1179
Brugia malayi hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus programmed cell death protein 0.0198 0.043 0.043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.0953 0.0953
Plasmodium vivax serine-repeat antigen (SERA) 0.025 0.0555 0.1988
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.025 0.0555 0.1988
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0045 0.0129
Toxoplasma gondii ABC1 family protein 0.0038 0.0052 0.0147
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Brugia malayi Kringle domain containing protein 0.0022 0.0015 0.0015
Trypanosoma cruzi metacaspase, putative 0.0018 0.0004 0.0004
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.019 0.0413 0.0413
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Brugia malayi calpain 7 0.1195 0.2792 0.2792
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0555 0.1597
Loa Loa (eye worm) hypothetical protein 0.025 0.0555 0.0555
Plasmodium falciparum serine repeat antigen 4 0.025 0.0555 0.2947
Trypanosoma brucei Aph-1 protein, putative 0.01 0.0198 0.0567
Onchocerca volvulus 0.0584 0.1345 0.286
Mycobacterium ulcerans lipase LipD 0.0038 0.0052 0.0366
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0271 0.0603 0.1723
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0478 0.1093 0.1093
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0083 0.0159 0.0159
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Giardia lamblia Cathepsin L-like protease 0.025 0.0555 0.1597
Brugia malayi Papain family cysteine protease containing protein 0.025 0.0555 0.0555
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0054 0.0054
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.025 0.0555 0.0555
Onchocerca volvulus 0.0022 0.0015 0.0032
Trichomonas vaginalis calmodulin-2, putative 0.019 0.0413 0.1187
Loa Loa (eye worm) papain family cysteine protease containing protein 0.025 0.0555 0.0555
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0054 0.0054
Schistosoma mansoni calmodulin related calcium binding protein 0.019 0.0413 0.0413
Entamoeba histolytica cysteine protease, putative 0.025 0.0555 0.2818
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0081 0.0154 0.0154
Trypanosoma cruzi cruzipain precursor, putative 0.0906 0.2108 0.2108
Plasmodium falciparum DNA repair protein RAD2, putative 0.0035 0.0044 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0584 0.1345 0.6826
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0347 0.0785 0.2258
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Trypanosoma cruzi kinesin, putative 0.0848 0.197 0.197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.2792
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0055 0.0157
Leishmania major centrin, putative 0.019 0.0413 0.1179
Entamoeba histolytica DNA-repair protein, putative 0.0035 0.0044 0.0225
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi calpain 5 0.0848 0.197 0.197
Giardia lamblia Cathepsin L precursor 0.025 0.0555 0.1597
Schistosoma mansoni thyroid hormone receptor 0.002 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.1093 0.5551
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0052
Plasmodium vivax unspecified product 0.0478 0.1093 0.3916
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0052
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.7976
Schistosoma mansoni calpain-2 (C02 family) 0.0347 0.0785 0.0785
Echinococcus granulosus inhibitor of apoptosis protein 0.0179 0.0387 0.0387
Plasmodium vivax centrin-1, putative 0.019 0.0413 0.1478
Onchocerca volvulus 0.0811 0.1883 0.4006
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.019 0.0413 0.2095
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0811 0.1883 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0006 0.0041
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Giardia lamblia Cathepsin B precursor 0.025 0.0555 0.1597
Trypanosoma brucei kinesin, putative 0.0848 0.197 0.5626
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0347 0.0785 0.2242
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0159
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0034 0.012
Loa Loa (eye worm) hypothetical protein 0.0061 0.0106 0.0106
Plasmodium falciparum peptidase, putative 0.0181 0.0392 0.2081
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0251 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0251 0.1781
Leishmania major cathepsin L-like protease 0.0906 0.2108 0.6021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Echinococcus multilocularis Mastin 0.0083 0.0159 0.0159
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1484 0.3476 0.3476
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0081 0.0154 0.0443
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.1093 0.5551
Brugia malayi Calmodulin-like protein 0.019 0.0413 0.0413
Entamoeba histolytica protein kinase, putative 0.0848 0.197 1
Onchocerca volvulus 0.2001 0.4701 1
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.015 0.0317 0.0913
Plasmodium falciparum plasmepsin VII 0.0017 0.0002 0.0012
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.0002 0.0007
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0181 0.0392 0.1119
Schistosoma mansoni hypothetical protein 0.0083 0.0159 0.0159
Brugia malayi Protein kinase domain containing protein 0.0022 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0136 0.0285 0.0285
Giardia lamblia GPI-anchor transamidase, putative 0.0035 0.0045 0.0129
Onchocerca volvulus Cell death protein 3 homolog 0.0154 0.0327 0.0695
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0054 0.0054
Brugia malayi Cathepsin L-like precursor 0.0811 0.1883 0.1883
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0011 0.0011
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1494 0.3501 1
Echinococcus multilocularis flap endonuclease 1 0.003 0.0034 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Brugia malayi Cathepsin L-like precursor 0.0227 0.0501 0.0501
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0009 0.0047
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0011 0.0011
Schistosoma mansoni calpain-7 (C02 family) 0.1195 0.2792 0.2792
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.025 0.0555 0.1597
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.025 0.0555 0.2947
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0611 0.1409 0.1409
Brugia malayi Flap endonuclease-1 0.003 0.0034 0.0034
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0611 0.1409 0.4024
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Leishmania major hypothetical protein, conserved 0.0022 0.0015 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.025 0.0555 0.1597
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0011 0.0011
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Onchocerca volvulus 0.025 0.0555 0.1181
Trypanosoma cruzi caltractin, putative 0.019 0.0413 0.0413
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3387 0.7981 0.7981
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0347 0.0785 0.2258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0076 0.0076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0369 0.0835 0.0835
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Entamoeba histolytica cysteine proteinase, putative 0.0811 0.1883 0.956
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.025 0.0555 0.1597
Brugia malayi calpain family protein 1 0.3197 0.7531 0.7531
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0063 0.0111 0.032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0006 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0011 0.0011
Schistosoma mansoni neuronal calcium sensor 0.019 0.0413 0.0413
Brugia malayi GPI-anchor transamidase 0.0035 0.0045 0.0045
Echinococcus granulosus Dipeptidyl peptidase 9 0.0271 0.0603 0.0603
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0271 0.0603 0.1723
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Trypanosoma brucei Calpain-like protein 2 0.0347 0.0785 0.2242
Brugia malayi Papain family cysteine protease containing protein 0.025 0.0555 0.0555
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0478 0.1093 0.3123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0055 0.0157
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0004 0.0004
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0179 0.0387 0.0387
Onchocerca volvulus 0.0048 0.0075 0.016
Loa Loa (eye worm) calpain 0.1195 0.2792 0.2792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0555 0.1597
Giardia lamblia Cathepsin B precursor 0.025 0.0555 0.1597
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Echinococcus granulosus EF hand domain containing family member A2 0.0193 0.042 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0052 0.0052
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0011 0.0011
Plasmodium falciparum proteasome subunit beta type-5 0.0081 0.0154 0.0818
Schistosoma mansoni flap endonuclease-1 0.0025 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.025 0.0555 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0555 0.1597
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0015
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0271 0.0603 0.0603
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0347 0.0785 0.0785
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3387 0.7981 0.7981
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0136 0.0285 0.0285
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0081 0.0154 0.0782
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0004 0.0004
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0011 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0038 0.0038
Leishmania major calmodulin, putative 0.019 0.0413 0.1179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0063 0.0111 0.0111
Onchocerca volvulus 0.0811 0.1883 0.4006
Loa Loa (eye worm) hypothetical protein 0.0233 0.0515 0.0515
Leishmania major cathepsin L-like protease 0.0811 0.1883 0.5379
Brugia malayi EF hand family protein 0.0193 0.042 0.042
Trypanosoma cruzi I/6 autoantigen, putative 0.019 0.0413 0.0413
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.015 0.0317 0.0913
Echinococcus multilocularis caspase 2 0.0154 0.0327 0.0327
Giardia lamblia Dipeptidyl-peptidase I precursor 0.025 0.0555 0.1597
Trichomonas vaginalis calmodulin, putative 0.0198 0.043 0.1238
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1484 0.3476 0.3476
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.002 0.0009 0.0009
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0006 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4239 1 1
Loa Loa (eye worm) hypothetical protein 0.0584 0.1345 0.1345
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0054 0.0054
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0002 0.0008
Onchocerca volvulus 0.0017 0.0002 0.0005
Trichomonas vaginalis calcium binding protein, putative 0.019 0.0413 0.1187
Echinococcus multilocularis EF hand domain containing family member A2 0.019 0.0413 0.0413
Giardia lamblia Cathepsin B precursor 0.1484 0.3476 1
Trypanosoma cruzi cysteine protease, putative 0.0478 0.1093 0.1093
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0054 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0054 0.0155
Plasmodium vivax unspecified product 0.025 0.0555 0.1988
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.025 0.0555 0.1988
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0054 0.0054
Echinococcus granulosus cysteine protease 0.0478 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.0227 0.0501 0.0501
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0011 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.1913 0.1913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0011 0.0011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0106 0.0106
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0555 0.1597
Loa Loa (eye worm) ctsf protein 0.0811 0.1883 0.1883
Trypanosoma cruzi kinesin, putative 0.0848 0.197 0.197
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.0392 0.0392
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0181 0.0392 0.1127
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0054 0.0054
Giardia lamblia Proteasome subunit beta type 1 0.0063 0.0111 0.032
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.019 0.0413 0.0413
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0015 0.0054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0251 0.1781
Toxoplasma gondii aspartyl protease ASP1 0.0017 0.0002 0.0007
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0009 0.0027
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0052 0.0366
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0081 0.0154 0.1094
Trypanosoma brucei oligopeptidase b 0.0611 0.1409 0.4024
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0108 0.0108
Toxoplasma gondii EF hand domain-containing protein 0.019 0.0413 0.1179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Schistosoma mansoni microtubule-associated protein tau 0.1408 0.3296 0.3296
Onchocerca volvulus 0.0038 0.0052 0.011
Giardia lamblia Cysteine protease 0.025 0.0555 0.1597
Plasmodium vivax calpain, putative 0.1195 0.2792 1
Echinococcus granulosus cathepsin L 0.0478 0.1093 0.1093
Plasmodium falciparum plasmepsin IV 0.0017 0.0002 0.0012
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0054 0.0054
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.0002 0.0007
Brugia malayi cathepsin Z-like cysteine proteinase 0.025 0.0555 0.0555
Echinococcus granulosus transmembrane protease serine 3 0.0083 0.0159 0.0159
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0193 0.042 0.042
Brugia malayi prolyl oligopeptidase family protein 0.0181 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.025 0.0555 0.0555
Schistosoma mansoni cathepsin S (C01 family) 0.025 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni centrin 0.019 0.0413 0.0413
Schistosoma mansoni neuronal calcium sensor 0.019 0.0413 0.0413
Echinococcus multilocularis calpain 5 0.1195 0.2792 0.2792
Loa Loa (eye worm) hypothetical protein 0.0811 0.1883 0.1883
Entamoeba histolytica cysteine proteinase 1, putative 0.0478 0.1093 0.5551
Echinococcus multilocularis caspase 0.0018 0.0004 0.0004
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0179 0.0387 0.0387
Plasmodium falciparum centrin-1 0.019 0.0413 0.2192
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0011 0.0011
Brugia malayi Cathepsin L-like cysteine proteinase 0.0584 0.1345 0.1345
Toxoplasma gondii troponin c, isotype gamma, putative 0.019 0.0413 0.1179
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0006 0.0006
Plasmodium falciparum plasmepsin V 0.0017 0.0002 0.0012
Brugia malayi Trypsin-like protease protein 5 0.0083 0.0159 0.0159
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.019 0.0413 0.1187
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0181 0.0392 0.1119
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0006 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.1093 0.5551
Brugia malayi gamma-secretase subunit aph-1 0.0256 0.0568 0.0568
Trichomonas vaginalis calmodulin, putative 0.019 0.0413 0.1187
Onchocerca volvulus 0.0083 0.0159 0.0338
Plasmodium falciparum metacaspase 1 0.0018 0.0004 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Echinococcus multilocularis EF HAND 1, calcium binding site 0.019 0.0413 0.0413
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0347 0.0785 0.0785
Schistosoma mansoni rab 0.019 0.0413 0.0413
Echinococcus multilocularis calmodulin 0.019 0.0413 0.0413
Echinococcus multilocularis EF hand domain containing family member A2 0.0193 0.042 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0584 0.1345 0.3868
Plasmodium vivax aspartyl protease, putative 0.0017 0.0002 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.025 0.0555 0.1597
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0011 0.0011
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0081 0.0154 0.0154
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0015 0.0043
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0081 0.0154 0.044
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Plasmodium falciparum cysteine proteinase falcipain 1 0.0478 0.1093 0.5806
Echinococcus multilocularis programmed cell death protein 0.0198 0.043 0.043
Trichomonas vaginalis calcium binding protein, putative 0.019 0.0413 0.1187
Echinococcus granulosus caspase 2 0.0154 0.0327 0.0327
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0093 0.0266
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0347 0.0785 0.0785
Trypanosoma cruzi major cysteine proteinase, putative 0.0345 0.078 0.078
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0811 0.1883 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0052 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0106 0.0302
Loa Loa (eye worm) hypothetical protein 0.1494 0.3501 0.3501
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.1093 0.3145
Leishmania major protein kinase, putative 0.019 0.0413 0.1179
Brugia malayi Pre-SET motif family protein 0.0061 0.0106 0.0106
Leishmania major calpain protease-like protein 0.0347 0.0785 0.2242
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.019 0.0413 0.0413
Plasmodium vivax proteasome subunit beta type-1, putative 0.0063 0.0111 0.0399
Trypanosoma cruzi calmodulin, putative 0.019 0.0413 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.0785 0.2258
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.025 0.0555 0.1597
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.2001 0.4701 0.4701
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0054 0.0054
Mycobacterium ulcerans beta-lactamase 0.0038 0.0052 0.0366
Trypanosoma brucei hypothetical protein, conserved 0.019 0.0413 0.1179
Leishmania major hypothetical protein, unknown function 0.0347 0.0785 0.2242
Loa Loa (eye worm) hypothetical protein 0.0179 0.0387 0.0387
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0022 0.0015 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0584 0.1345 0.1345
Echinococcus granulosus acylamino acid releasing enzyme 0.0181 0.0392 0.0392
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0347 0.0785 0.2242
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0181 0.0392 0.0392
Trypanosoma brucei calpain-like protein, putative 0.1195 0.2792 0.7976
Entamoeba histolytica hypothetical protein, conserved 0.0181 0.0392 0.1989
Trypanosoma brucei calpain-like protein, putative 0.1195 0.2792 0.7976
Trypanosoma brucei Calpain-like protein 1.2 0.0347 0.0785 0.2242
Brugia malayi proteasome subunit beta type 2 0.0039 0.0055 0.0055
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0054 0.0054
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0006 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Brugia malayi prolyl oligopeptidase family protein 0.0181 0.0392 0.0392
Echinococcus granulosus calpain 7 C02 family 0.1195 0.2792 0.2792
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0011 0.0011
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Plasmodium vivax vivapain-3 0.0478 0.1093 0.3916
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0011 0.0011
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0347 0.0785 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.025 0.0555 0.1597
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0478 0.1093 0.1093
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0054 0.0054
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0501 0.1149 0.2444
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0159
Onchocerca volvulus 0.0476 0.109 0.2319
Toxoplasma gondii hypothetical protein 0.0181 0.0392 0.1119
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.019 0.0413 0.1187
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0015 0.0015
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.019 0.0413 0.1478
Onchocerca volvulus 0.0811 0.1883 0.4006
Leishmania major metacaspase, putative 0.0018 0.0004 0.0013
Trichomonas vaginalis calpain, putative 0.0347 0.0785 0.2258
Loa Loa (eye worm) calpain family protein 1 0.2349 0.5524 0.5524
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1484 0.3476 0.9929
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0054 0.0054
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.002 0.0009 0.0009
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0075 0.0075
Brugia malayi beta-lactamase family protein 0.0038 0.0052 0.0052
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3197 0.7531 0.7531
Onchocerca volvulus 0.0083 0.0159 0.0338
Giardia lamblia Thymus-specific serine protease precursor 0.002 0.0009 0.0027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0011 0.0011
Brugia malayi hypothetical protein 0.0089 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0044 0.0044
Loa Loa (eye worm) papain family cysteine protease containing protein 0.025 0.0555 0.0555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0011 0.0011
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0034 0.0034
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Plasmodium falciparum plasmepsin VI 0.0017 0.0002 0.0012
Brugia malayi programmed cell death protein 6 0.019 0.0413 0.0413
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0054 0.0054
Trichomonas vaginalis myosin light chain 1, putative 0.019 0.0413 0.1187
Schistosoma mansoni survival motor neuron protein 0.0048 0.0075 0.0075
Brugia malayi hypothetical protein 0.0039 0.0054 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0011 0.0011
Entamoeba histolytica grainin, putative 0.0193 0.042 0.2134
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0081 0.0154 0.0502
Mycobacterium ulcerans hypothetical protein 0.0083 0.0159 0.1129
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0034 0.0034
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0081 0.0154 0.0443
Brugia malayi Serine carboxypeptidase S28 family protein 0.002 0.0009 0.0009
Brugia malayi EF hand family protein 0.019 0.0413 0.0413
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0055 0.0055
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0052 0.0168
Giardia lamblia Cathepsin B precursor 0.025 0.0555 0.1597
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0006 0.5
Brugia malayi steroid hormone receptor 0.002 0.0011 0.0011
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0004 0.0004
Brugia malayi prolyl oligopeptidase family protein 0.0271 0.0603 0.0603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0347 0.0785 0.2258
Brugia malayi nuclear receptor NHR-88 0.002 0.0011 0.0011
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0501 0.0501
Giardia lamblia Cathepsin L precursor 0.025 0.0555 0.1597
Echinococcus multilocularis apoptotic protease activating factor 1 0.0136 0.0285 0.0285
Onchocerca volvulus 0.019 0.0413 0.0878
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.025 0.0555 0.1988
Echinococcus multilocularis calpain 7 (C02 family) 0.1195 0.2792 0.2792
Giardia lamblia Alanyl dipeptidyl peptidase 0.0181 0.0392 0.1127
Toxoplasma gondii hypothetical protein 0.0347 0.0785 0.2242
Schistosoma mansoni cathepsin C 0.025 0.0555 0.0555
Entamoeba histolytica calpain large subunit domain III containing protein 0.0848 0.197 1
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0515 0.0515
Echinococcus granulosus prolyl endopeptidase 0.1494 0.3501 0.3501
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1195 0.2792 0.2792
Leishmania major phospholipase c-like protein 0.019 0.0413 0.1179
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0035 0.0045 0.0128
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0052 0.0185
Onchocerca volvulus Cathepsin L homolog 0.0811 0.1883 0.4006
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3387 0.7981 0.7981
Brugia malayi Cathepsin L-like precursor 0.0584 0.1345 0.1345
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0413 0.1187
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0054 0.0054
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0002 0.0002
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0054 0.0054
Brugia malayi Cytochrome P450 family protein 0.0032 0.0038 0.0038
Onchocerca volvulus 0.0083 0.0159 0.0338
Entamoeba histolytica prolyl oligopeptidase family protein 0.0181 0.0392 0.1989
Onchocerca volvulus 0.002 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.2349 0.5524 0.5524
Trypanosoma cruzi oligopeptidase b 0.0611 0.1409 0.1409
Echinococcus multilocularis calbindin 32 0.0193 0.042 0.042
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0035 0.0045 0.0128
Onchocerca volvulus Prolyl endopeptidase homolog 0.1494 0.3501 0.7447
Brugia malayi fibroinase precursor 0.025 0.0555 0.0555
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0251 0.0817
Trypanosoma brucei cysteine peptidase C (CPC) 0.1484 0.3476 0.9929
Brugia malayi ecdysteroid receptor 0.002 0.0011 0.0011
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0063 0.0111 0.0111
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0054 0.0054
Brugia malayi prolyl oligopeptidase family protein 0.0501 0.1149 0.1149
Echinococcus multilocularis cysteine protease 0.0811 0.1883 0.1883
Brugia malayi Papain family cysteine protease containing protein 0.025 0.0555 0.0555
Schistosoma mansoni hypothetical protein 0.0048 0.0075 0.0075
Trypanosoma brucei mitochondrial calcium uptake 1 0.019 0.0413 0.1179
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0045 0.0129
Trypanosoma brucei Calpain-like protein 1.1 0.0347 0.0785 0.2242
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.025 0.0555 0.1597
Giardia lamblia Cysteine protease 0.025 0.0555 0.1597
Loa Loa (eye worm) hypothetical protein 0.025 0.0555 0.0555
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0347 0.0785 0.0785
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0413 0.1187
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0054 0.0054
Leishmania major cathepsin L-like protease 0.0811 0.1883 0.5379
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0611 0.1409 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0054 0.0054
Brugia malayi calpain D 0.0347 0.0785 0.0785
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0679 0.1569 0.1569
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.025 0.0555 0.1988
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0555 0.1597
Brugia malayi Papain family cysteine protease containing protein 0.0811 0.1883 0.1883
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.025 0.0555 0.0555
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0181 0.0392 0.1989
Echinococcus granulosus centrin 2 0.019 0.0413 0.0413
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.0198 0.0198
Toxoplasma gondii preprocathepsin c precursor, putative 0.025 0.0555 0.1585
Entamoeba histolytica cysteine protease, putative 0.0811 0.1883 0.956
Schistosoma mansoni hemoglobinase (C13 family) 0.015 0.0317 0.0317
Echinococcus granulosus cathepsin l1 0.0811 0.1883 0.1883
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.019 0.0413 0.2095
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0584 0.1345 0.1345
Echinococcus multilocularis calpain A 0.339 0.7989 0.7989
Brugia malayi hypothetical protein 0.0039 0.0054 0.0054
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0532 0.1733
Trypanosoma cruzi cysteine peptidase, putative 0.0906 0.2108 0.2108
Entamoeba histolytica prolyl oligopeptidase family protein 0.0181 0.0392 0.1989
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0251 0.0717
Entamoeba histolytica cysteine protease, putative 0.025 0.0555 0.2818
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0148
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.019 0.0413 0.0413
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0054 0.0054
Plasmodium vivax aspartyl protease, putative 0.0017 0.0002 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.019 0.0413 0.0413
Trichomonas vaginalis calcium binding proteins, putative 0.019 0.0413 0.1187
Entamoeba histolytica calmodulin, putative 0.019 0.0413 0.2095
Schistosoma mansoni reticulocalbin 0.019 0.0413 0.0413
Toxoplasma gondii cathepsin CPL 0.0811 0.1883 0.5379
Toxoplasma gondii prolyl endopeptidase 0.1494 0.3501 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1195 0.2792 0.7976
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0052 0.0052
Plasmodium falciparum GPI-anchor transamidase, putative 0.0035 0.0045 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0052
Entamoeba histolytica prolyl oligopeptidase family protein 0.0181 0.0392 0.1989
Loa Loa (eye worm) hypothetical protein 0.0154 0.0327 0.0327
Plasmodium vivax metacaspase 1, putative 0.0018 0.0004 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.025 0.0555 0.1597
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0251 0.0251
Brugia malayi proteasome subunit beta type 1 0.0063 0.0111 0.0111
Echinococcus multilocularis calcium uptake protein 1 0.0193 0.042 0.042
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0179 0.0387 0.0387
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Entamoeba histolytica calcium-binding protein, putative 0.019 0.0413 0.2095
Echinococcus multilocularis enteropeptidase 0.0083 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0052
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0054 0.0054
Schistosoma mansoni inhibitor of apoptosis protein 0.0179 0.0387 0.0387
Echinococcus granulosus cathepsin L cysteine proteinase 0.0811 0.1883 0.1883
Onchocerca volvulus 0.0049 0.0079 0.0169
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0811 0.1883 0.1883
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0006 0.0029
Echinococcus multilocularis cathepsin b 0.4239 1 1
Trypanosoma cruzi centrin-3 0.0198 0.043 0.043
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0004 0.0016
Leishmania major cathepsin L-like protease 0.0811 0.1883 0.5379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Loa Loa (eye worm) hypothetical protein 0.025 0.0555 0.0555
Brugia malayi cathepsin L-like precursor 0.0584 0.1345 0.1345
Onchocerca volvulus Deterin homolog 0.0179 0.0387 0.0823
Brugia malayi Angiotensin-converting enzyme family protein 0.1835 0.4306 0.4306
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1313 0.3071 1
Entamoeba histolytica cysteine protease, putative 0.025 0.0555 0.2818
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0076 0.0076
Leishmania major calmodulin-like protein 0.019 0.0413 0.1179
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.025 0.0555 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0011 0.0011
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.002 0.0009 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0076 0.0076
Trypanosoma brucei antigen, putative 0.1195 0.2792 0.7976
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Brugia malayi Cytochrome P450 family protein 0.0053 0.0087 0.0087
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1494 0.3501 0.3501
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0347 0.0785 0.2258
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0148
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0106 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0181 0.0392 0.1403
Plasmodium vivax serine-repeat antigen (SERA), putative 0.025 0.0555 0.1988
Loa Loa (eye worm) hypothetical protein 0.0181 0.0392 0.0392
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0004 0.0013
Echinococcus multilocularis calmodulin 0.019 0.0413 0.0413
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0035 0.0044 0.0044
Entamoeba histolytica hypothetical protein, conserved 0.0193 0.042 0.2134
Trichomonas vaginalis calcium binding protein, putative 0.019 0.0413 0.1187
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0002 0.0008
Giardia lamblia Alanyl dipeptidyl peptidase 0.0181 0.0392 0.1127
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0811 0.1883 0.1883
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0168
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0055 0.0055
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0811 0.1883 0.1883
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0501 0.1149 0.1149
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0038 0.0052 0.0147
Trypanosoma cruzi metacaspase, putative 0.0018 0.0004 0.0004
Echinococcus granulosus sarcoplasmic calcium binding protein 0.019 0.0413 0.0413
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0054 0.0054
Trypanosoma brucei metacaspase 0.0018 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0159
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0034 0.0096
Echinococcus granulosus cathepsin L cysteine protease 0.0478 0.1093 0.1093
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.0198 0.0198
Trypanosoma cruzi oligopeptidase b 0.0611 0.1409 0.1409
Echinococcus granulosus gamma secretase subunit aph 1 0.0256 0.0568 0.0568
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.019 0.0413 0.1179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0076 0.0076
Entamoeba histolytica calmodulin, putative 0.019 0.0413 0.2095
Trypanosoma cruzi 20S proteasome subunit 0.0039 0.0055 0.0055
Plasmodium vivax plasmepsin V, putative 0.0017 0.0002 0.0008
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0611 0.1409 1
Leishmania major programmed cell death 6 protein-like protein 0.019 0.0413 0.1179
Onchocerca volvulus 0.0811 0.1883 0.4006
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0052 0.0168
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Onchocerca volvulus 0.0811 0.1883 0.4006
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0063 0.0111 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Echinococcus multilocularis cathepsin L 0.025 0.0555 0.0555
Echinococcus multilocularis gamma secretase subunit aph 1 0.0256 0.0568 0.0568
Echinococcus multilocularis glycoprotein Antigen 5 0.0083 0.0159 0.0159
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0045 0.0129
Plasmodium falciparum plasmepsin II 0.0017 0.0002 0.0012
Plasmodium falciparum metacaspase-like protein 0.0018 0.0004 0.0023
Schistosoma mansoni calmodulin 0.019 0.0413 0.0413
Giardia lamblia Cathepsin L precursor 0.025 0.0555 0.1597
Echinococcus granulosus enteropeptidase 0.0083 0.0159 0.0159
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0054 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0011 0.0011
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0004 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0063 0.0111 0.0318
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0076 0.0076
Trypanosoma brucei prolyl endopeptidase 0.1494 0.3501 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0015 0.0015
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.025 0.0555 0.1988
Echinococcus multilocularis cathepsin b 0.4239 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Probable peptidase 0.0611 0.1409 0.4587
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0347 0.0785 0.2242
Echinococcus multilocularis calumenin 0.0193 0.042 0.042
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0515 0.0515
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0034 0.0097
Leishmania major cytochrome p450-like protein 0.0032 0.0038 0.0109
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0004 0.0013
Giardia lamblia Proteasome subunit beta type 2 0.0039 0.0055 0.0157
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1494 0.3501 0.3501
Trichomonas vaginalis hypothetical protein 0.0347 0.0785 0.2258
Echinococcus granulosus microtubule associated protein 2 0.1408 0.3296 0.3296
Schistosoma mansoni cathepsin s 0.0227 0.0501 0.0501
Echinococcus granulosus calpain A 0.339 0.7989 0.7989
Trichomonas vaginalis calpain, putative 0.0347 0.0785 0.2258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Trypanosoma brucei Metacaspase-4 0.0018 0.0004 0.0013
Echinococcus granulosus GPI anchor transamidase 0.0035 0.0045 0.0045
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0002 0.0002
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0017 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0151 0.032 0.032
Trypanosoma cruzi cruzipain precursor, putative 0.0227 0.0501 0.0501
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0052 0.0168
Entamoeba histolytica cysteine protease, putative 0.025 0.0555 0.2818
Trichomonas vaginalis calcineurin B subunit, putative 0.019 0.0413 0.1187
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0004 0.0004
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0063 0.0111 0.0591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0054 0.0054
Onchocerca volvulus 0.0193 0.042 0.0894
Echinococcus multilocularis tumor protein p63 0.0337 0.0761 0.0761
Leishmania major cysteine peptidase A (CPA) 0.0811 0.1883 0.5379
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0347 0.0785 0.2258
Brugia malayi Cathepsin L-like precursor 0.0811 0.1883 0.1883
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0054 0.0054
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0181 0.0392 0.0392
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4239 1 1
Giardia lamblia Cathepsin L-like protease 0.025 0.0555 0.1597
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0011 0.0011
Trypanosoma cruzi metacaspase, putative 0.0018 0.0004 0.0004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0811 0.1883 0.1883
Onchocerca volvulus Cathepsin F homolog 0.0811 0.1883 0.4006
Echinococcus multilocularis neuronal calcium sensor 0.019 0.0413 0.0413
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0179 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0159
Echinococcus multilocularis cathepsin L cysteine protease 0.0811 0.1883 0.1883
Trypanosoma cruzi cysteine proteinase, putative 0.0478 0.1093 0.1093
Mycobacterium ulcerans proteasome PrcB 0.0081 0.0154 0.1094
Echinococcus multilocularis centrin 2 0.019 0.0413 0.0413
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.025 0.0555 0.1988
Leishmania major calcineurin B subunit, putative 0.019 0.0413 0.1179
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0052 0.0052
Entamoeba histolytica papain family cysteine protease domain containing protein 0.025 0.0555 0.2818
Plasmodium falciparum serine repeat antigen 2 0.025 0.0555 0.2947
Plasmodium vivax vivapain-2 0.0811 0.1883 0.6744
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0039 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0054 0.0155
Schistosoma mansoni neuronal calcium sensor 0.019 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Schistosoma mansoni thyroid hormone receptor 0.002 0.0011 0.0011
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0347 0.0785 0.0785
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1195 0.2792 0.2792
Brugia malayi hypothetical protein 0.0136 0.0285 0.0285
Toxoplasma gondii calcium-dependent protein kinase 0.0193 0.042 0.12
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0168
Trypanosoma brucei I/6 autoantigen 0.019 0.0413 0.1179
Echinococcus granulosus cpg binding protein 0.003 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.025 0.0555 0.2818
Echinococcus multilocularis programmed cell death protein 0.0198 0.043 0.043
Toxoplasma gondii EFHC1, putative 0.019 0.0413 0.1179
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0052 0.0168
Trypanosoma brucei calpain-like protein, putative 0.1195 0.2792 0.7976
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0035 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1835 0.4306 0.4306
Brugia malayi cahepsin L-like non-peptiedase homolog 0.025 0.0555 0.0555
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0038 0.0038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1195 0.2792 0.2792
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0009 0.0009
Brugia malayi hypothetical protein 0.0151 0.032 0.032
Trypanosoma cruzi metacaspase, putative 0.0018 0.0004 0.0004
Trichomonas vaginalis calmodulin, putative 0.019 0.0413 0.1187
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0011 0.0023
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0052 0.0168
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0017 0.0002 0.0007
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0271 0.0603 0.0603
Schistosoma mansoni hypothetical protein 0.019 0.0413 0.0413
Echinococcus multilocularis neurocalcin 0.019 0.0413 0.0413
Echinococcus granulosus calpain 5 0.1195 0.2792 0.2792
Onchocerca volvulus 0.0083 0.0159 0.0338
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0035 0.0044 0.0127
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0002 0.0002
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0227 0.0501 0.0501
Toxoplasma gondii calmodulin CAM1 0.0193 0.042 0.12
Echinococcus granulosus Mastin 0.0083 0.0159 0.0159
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.015 0.0317 0.0913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.025 0.0555 0.1597
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0052 0.0366
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Leishmania major hypothetical protein, conserved 0.019 0.0413 0.1179
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0035 0.0045 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0052 0.0147
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0034 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0054 0.0155
Echinococcus multilocularis caspase 8 0.0018 0.0004 0.0004
Giardia lamblia Cathepsin B precursor 0.1484 0.3476 1
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0002 0.0002
Mycobacterium leprae Probable lipase LipE 0.0038 0.0052 0.0366
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.025 0.0555 0.1988
Trypanosoma brucei proteasome beta 6 subunit 0.0063 0.0111 0.0318
Plasmodium vivax GPI-anchor transamidase, putative 0.0035 0.0045 0.016
Trypanosoma brucei cysteine peptidase, putative 0.0347 0.0785 0.2242
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0052
Plasmodium falciparum serine repeat antigen 6 0.025 0.0555 0.2947
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0009 0.0009
Loa Loa (eye worm) cysteine protease 0.0811 0.1883 0.1883
Toxoplasma gondii serine carboxypeptidase s28 protein 0.002 0.0009 0.0026
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0006
Brugia malayi cathepsin L precursor 0.025 0.0555 0.0555
Trichomonas vaginalis calcineurin B subunit, putative 0.0193 0.042 0.1209
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0083 0.0159 0.0159
Onchocerca volvulus Cathepsin L homolog 0.025 0.0555 0.1181
Brugia malayi nuclear hormone receptor 0.002 0.0011 0.0011
Loa Loa (eye worm) calmodulin-like protein 0.019 0.0413 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0054 0.0155
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Echinococcus multilocularis calpain 0.1195 0.2792 0.2792
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0011 0.0011
Onchocerca volvulus 0.002 0.0009 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Echinococcus multilocularis transmembrane protease serine 3 0.0083 0.0159 0.0159
Leishmania major cathepsin L-like protease 0.0811 0.1883 0.5379
Echinococcus multilocularis prolyl endopeptidase 0.1494 0.3501 0.3501
Brugia malayi cathepsin Z-like cysteine proteinase 0.025 0.0555 0.0555
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0251 0.0717
Trypanosoma cruzi centrin, putative 0.0198 0.043 0.043
Trypanosoma brucei metacaspase MCA2 0.0018 0.0004 0.0013
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0181 0.0392 0.1989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.7976
Onchocerca volvulus 0.0811 0.1883 0.4006
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.002 0.0009 0.0027
Echinococcus granulosus tumor protein p63 0.0337 0.0761 0.0761
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.025 0.0555 0.1597
Plasmodium vivax vivapain-2 0.0811 0.1883 0.6744
Brugia malayi calpain family protein 1 0.3197 0.7531 0.7531
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Schistosoma mansoni hemoglobinase (C13 family) 0.015 0.0317 0.0317
Echinococcus multilocularis expressed protein 0.0753 0.1746 0.1746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Brugia malayi XPG N-terminal domain containing protein 0.0029 0.0032 0.0032
Onchocerca volvulus Legumain homolog 0.015 0.0317 0.0675
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0181 0.0392 0.0392
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0011 0.0023
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Trichomonas vaginalis calmodulin, putative 0.0193 0.042 0.1209
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0369 0.0835 0.0835
Echinococcus granulosus caspase 8 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Loa Loa (eye worm) cathepsin B 0.1484 0.3476 0.3476
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0347 0.0785 0.0785
Plasmodium vivax plasmepsin IV, putative 0.0017 0.0002 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0011 0.0011
Schistosoma mansoni calmodulin 0.019 0.0413 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0027
Plasmodium vivax DNA repair protein RAD2, putative 0.0035 0.0044 0.0159
Onchocerca volvulus Cathepsin L homolog 0.0811 0.1883 0.4006
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.7976
Echinococcus granulosus calpain 0.1195 0.2792 0.2792
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0011 0.0011
Loa Loa (eye worm) calpain family protein 1 0.3197 0.7531 0.7531
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0011 0.0011
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.015 0.0317 0.0913
Trypanosoma cruzi calmodulin, putative 0.019 0.0413 0.0413
Brugia malayi cathepsin F-like cysteine proteinase 0.0227 0.0501 0.0501
Trypanosoma brucei centrin, putative 0.019 0.0413 0.1179
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0271 0.0603 0.1723
Echinococcus granulosus EF hand domain containing family member A2 0.019 0.0413 0.0413
Entamoeba histolytica hypothetical protein 0.0039 0.0054 0.0274
Leishmania major cathepsin L-like protease 0.0811 0.1883 0.5379
Schistosoma mansoni hypothetical protein 0.0115 0.0235 0.0235
Trypanosoma cruzi cysteine peptidase, putative 0.0906 0.2108 0.2108
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0039 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.019 0.0413 0.0413
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0611 0.1409 0.4587
Onchocerca volvulus 0.0038 0.0052 0.011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0038 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.0392 0.0392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Leishmania major cathepsin L-like protease 0.0906 0.2108 0.6021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.2792
Leishmania major calmodulin, putative 0.019 0.0413 0.1179
Schistosoma mansoni hypothetical protein 0.0399 0.0907 0.0907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0478 0.1093 0.3123
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0039 0.0055 0.0156
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0159
Echinococcus multilocularis inhibitor of apoptosis protein 0.0179 0.0387 0.0387
Echinococcus multilocularis acylamino acid releasing enzyme 0.0181 0.0392 0.0392
Echinococcus multilocularis hypothetical protein 0.1195 0.2792 0.2792
Giardia lamblia Dipeptidyl-peptidase I precursor 0.025 0.0555 0.1597
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0004 0.0004
Echinococcus granulosus EF HAND 1 calcium binding site 0.019 0.0413 0.0413
Brugia malayi Proteasome A-type and B-type family protein 0.0081 0.0154 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0011 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0006 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.025 0.0555 0.0555
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Trypanosoma brucei hypothetical protein 0.0347 0.0785 0.2242
Brugia malayi Cell death protein 3 precursor 0.0154 0.0327 0.0327
Trypanosoma brucei metacaspase MCA3 0.0018 0.0004 0.0013
Giardia lamblia Dipeptidyl-peptidase I precursor 0.025 0.0555 0.1597
Toxoplasma gondii cathepsin CPC2 0.025 0.0555 0.1585
Trypanosoma cruzi calmodulin, putative 0.019 0.0413 0.0413
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0063 0.0111 0.0318
Loa Loa (eye worm) calpain 5 0.0848 0.197 0.197
Schistosoma mansoni reticulocalbin 0.0193 0.042 0.042
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0347 0.0785 0.0785
Toxoplasma gondii peptidase c13 family protein 0.0035 0.0045 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.025 0.0555 0.1597
Leishmania major hypothetical protein, conserved 0.0193 0.042 0.12
Schistosoma mansoni cathepsin F (C01 family) 0.0811 0.1883 0.1883
Schistosoma mansoni centrin-related 0.019 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Onchocerca volvulus 0.0083 0.0159 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.025 0.0555 0.1597
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0076 0.0076
Plasmodium falciparum plasmepsin I 0.0017 0.0002 0.0012
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0015 0.008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Plasmodium falciparum serine repeat antigen 9 0.025 0.0555 0.2947
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0013
Echinococcus granulosus calbindin 32 0.0193 0.042 0.042
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Trypanosoma cruzi cysteine proteinase, putative 0.0478 0.1093 0.1093
Plasmodium falciparum serine repeat antigen 7 0.025 0.0555 0.2947
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.0907 0.0907
Entamoeba histolytica Flap nuclease, putative 0.003 0.0034 0.0171
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0347 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0271 0.0603 0.0603
Schistosoma mansoni hypothetical protein 0.0347 0.0785 0.0785
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.015 0.0317 0.0913
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0054 0.0054
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0052 0.0052
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0013
Schistosoma mansoni coup transcription factor 0.002 0.0011 0.0011
Toxoplasma gondii cathepsin CPC1 0.025 0.0555 0.1585
Echinococcus multilocularis cathepsin L cysteine protease 0.0811 0.1883 0.1883
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0811 0.1883 0.5417
Trypanosoma cruzi conserved protein 0.0347 0.0785 0.0785
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.025 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0052
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Plasmodium falciparum cysteine proteinase falcipain 3 0.0811 0.1883 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.0031
Echinococcus granulosus flap endonuclease 1 0.003 0.0034 0.0034
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0193 0.042 0.042
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0052 0.0168
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0083 0.0159 0.0159
Loa Loa (eye worm) peptidase C13 family protein 0.015 0.0317 0.0317
Trichomonas vaginalis calpain, putative 0.0347 0.0785 0.2258
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Echinococcus granulosus cathepsin L 0.025 0.0555 0.0555
Onchocerca volvulus 0.0061 0.0106 0.0225
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0054 0.0054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0106 0.0106
Trypanosoma cruzi centrin, putative 0.0198 0.043 0.043
Plasmodium falciparum serine repeat antigen 8 0.025 0.0555 0.2947
Giardia lamblia Hypothetical protein 0.025 0.0555 0.1597
Plasmodium vivax serine-repeat antigen (SERA) 0.025 0.0555 0.1988
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0011 0.0011
Echinococcus multilocularis cysteine protease 0.0811 0.1883 0.1883
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0106 0.0106
Trypanosoma cruzi prolyl endopeptidase 0.1494 0.3501 0.3501
Trichomonas vaginalis flap endonuclease-1, putative 0.0035 0.0044 0.0128
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0584 0.1345 0.3868
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.015 0.0317 0.0317
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0089 0.0174 0.0174
Schistosoma mansoni mitochondrial solute carrier 0.019 0.0413 0.0413
Brugia malayi beta-lactamase family protein 0.0038 0.0052 0.0052
Plasmodium falciparum flap endonuclease 1 0.003 0.0034 0.0178
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.019 0.0413 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0392 0.1127
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0052 0.0148
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0347 0.0785 0.0785
Echinococcus granulosus calpain A 0.1195 0.2792 0.2792
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0054 0.0054
Giardia lamblia Hypothetical protein 0.0193 0.042 0.1209
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Echinococcus granulosus calumenin 0.0193 0.042 0.042
Entamoeba histolytica papain family cysteine protease domain containing protein 0.025 0.0555 0.2818
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3387 0.7981 0.7981
Schistosoma mansoni gamma-secretase subunit aph-1 0.0256 0.0568 0.0568
Toxoplasma gondii proteasome subunit beta type, putative 0.0081 0.0154 0.044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.025 0.0555 0.0555
Leishmania major hypothetical protein, conserved 0.0347 0.0785 0.2242
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.025 0.0555 0.0555
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0079 0.0079
Toxoplasma gondii cathepsin B 0.1484 0.3476 0.9929
Brugia malayi hypothetical protein 0.0233 0.0515 0.0515
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0029 0.0029
Echinococcus granulosus cathepsin b 0.4239 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0006 0.0016
Onchocerca volvulus 0.0028 0.0029 0.0061
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.015 0.0317 0.0913
Leishmania major cathepsin L-like protease 0.0906 0.2108 0.6021
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0054 0.0054
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.2792
Entamoeba histolytica cysteine proteinase, putative 0.0811 0.1883 0.956
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Schistosoma mansoni neuronal calcium sensor 0.019 0.0413 0.0413
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Loa Loa (eye worm) hypothetical protein 0.2849 0.6708 0.6708
Schistosoma mansoni cpg binding protein 0.003 0.0032 0.0032
Brugia malayi Papain family cysteine protease containing protein 0.0478 0.1093 0.1093
Trypanosoma brucei caltractin, putative 0.0198 0.043 0.1229
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Toxoplasma gondii centrin, putative 0.019 0.0413 0.1179
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0039 0.0055 0.0277
Trypanosoma brucei calmodulin, putative 0.019 0.0413 0.1179
Trichomonas vaginalis calmodulin, putative 0.019 0.0413 0.1187
Trypanosoma cruzi I/6 autoantigen, putative 0.019 0.0413 0.0413
Leishmania major centrin, putative 0.019 0.0413 0.1179
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0251 0.0251
Loa Loa (eye worm) trypsin family protein 0.0083 0.0159 0.0159
Echinococcus granulosus proteasome prosome macropain 0.0081 0.0154 0.0154
Plasmodium vivax vivapain-1 0.0478 0.1093 0.3916
Trypanosoma brucei Calpain-like protein CALP1.3 0.0347 0.0785 0.2242
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Plasmodium falciparum plasmepsin IX 0.0017 0.0002 0.0012
Loa Loa (eye worm) EF hand family protein 0.019 0.0413 0.0413
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0011 0.0011
Plasmodium vivax aspartyl protease, putative 0.0017 0.0002 0.0008
Trichomonas vaginalis calmodulin, putative 0.019 0.0413 0.1187
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0347 0.0785 0.2258
Trypanosoma brucei calpain, putative 0.0347 0.0785 0.2242
Entamoeba histolytica grainin 2 0.0198 0.043 0.2184
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0054 0.0054
Brugia malayi Pepsin A precursor 0.0017 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0478 0.1093 0.1093
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0009 0.0027
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0369 0.0835 0.0835
Trypanosoma brucei calpain-like protein, putative 0.1195 0.2792 0.7976
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.025 0.0555 0.0555
Trypanosoma brucei Component of motile flagella 41 0.019 0.0413 0.1179
Echinococcus granulosus glycoprotein Antigen 5 0.0083 0.0159 0.0159
Brugia malayi Peptidase C13 family protein 0.015 0.0317 0.0317
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0039 0.0055 0.029
Loa Loa (eye worm) proteasome subunit beta type 1 0.0063 0.0111 0.0111
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0256 0.0568 0.0568
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0002 0.0002
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.0159 0.0159
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Giardia lamblia Cathepsin B precursor 0.1484 0.3476 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0017
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.2792
Entamoeba histolytica cysteine protease, putative 0.0478 0.1093 0.5551
Leishmania major proteasome beta 5 subunit, putative 0.0081 0.0154 0.044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.025 0.0555 0.0555
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4239 1 1
Loa Loa (eye worm) hypothetical protein 0.0584 0.1345 0.1345
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0063 0.0111 0.0111
Plasmodium vivax proteasome subunit beta type-5, putative 0.0081 0.0154 0.0552
Echinococcus multilocularis calpain family protein 1, d 0.2349 0.5524 0.5524
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0038 0.0038
Giardia lamblia Cathepsin L precursor 0.025 0.0555 0.1597
Entamoeba histolytica calcium binding family protein 0.019 0.0413 0.2095
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0159
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.0159 0.0159
Brugia malayi PXA domain containing protein 0.0039 0.0054 0.0054
Brugia malayi hypothetical protein 0.0083 0.0159 0.0159
Echinococcus granulosus expressed protein 0.0753 0.1746 0.1746
Brugia malayi Cathepsin L-like precursor 0.0811 0.1883 0.1883
Schistosoma mansoni calpain (C02 family) 0.1195 0.2792 0.2792
Trypanosoma cruzi cysteine peptidase, putative 0.0478 0.1093 0.1093
Giardia lamblia Cathepsin L precursor 0.025 0.0555 0.1597
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0106 0.0106
Trypanosoma brucei calmodulin, putative 0.0193 0.042 0.12
Echinococcus granulosus neurocalcin 0.019 0.0413 0.0413
Echinococcus granulosus apoptotic protease activating factor 1 0.0136 0.0285 0.0285
Schistosoma mansoni memapsin-2 (A01 family) 0.0421 0.0959 0.0959
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1484 0.3476 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0251 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0013
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0011 0.0011
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.025 0.0555 0.2947
Brugia malayi calcium-binding protein 0.019 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Toxoplasma gondii aspartyl protease 0.0017 0.0002 0.0007
Leishmania major kinesin, putative 0.0848 0.197 0.5626
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0009 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0052
Loa Loa (eye worm) fibroinase 0.0811 0.1883 0.1883
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1195 0.2792 0.2792
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0009 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Giardia lamblia Cysteine protease 0.025 0.0555 0.1597
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0006 0.0006
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.2242
Schistosoma mansoni hypothetical protein 0.019 0.0413 0.0413
Trichomonas vaginalis centrin, putative 0.019 0.0413 0.1187
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4239 1 1
Trichomonas vaginalis calmodulin, putative 0.019 0.0413 0.1187
Plasmodium falciparum plasmepsin VIII, putative 0.0017 0.0002 0.0012
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0054 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0087 0.0087
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0081 0.0154 0.0154
Onchocerca volvulus 0.0811 0.1883 0.4006
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0035 0.0044 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0011 0.0011
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0501 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0227 0.0501 0.0501
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0054 0.0054
Schistosoma mansoni ef hand domain family member A2 0.019 0.0413 0.0413
Plasmodium vivax serine-repeat antigen (SERA), putative 0.025 0.0555 0.1988
Schistosoma mansoni cpg binding protein 0.003 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0271 0.0603 0.0603
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Onchocerca volvulus 0.0083 0.0159 0.0338
Loa Loa (eye worm) hypothetical protein 0.0227 0.0501 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0148
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0052 0.0366
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0611 0.1409 0.4024
Onchocerca volvulus 0.0017 0.0002 0.0005
Brugia malayi Cathepsin L-like precursor 0.0811 0.1883 0.1883
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0054 0.0155
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0347 0.0785 0.0785
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0083 0.0159 0.0159
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0347 0.0785 0.2242
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1195 0.2792 0.7976
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0179 0.0387 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0011 0.0011
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0181 0.0392 0.1127
Leishmania major oligopeptidase b 0.0611 0.1409 0.4024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0099 0.0099
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0009 0.0047
Trichomonas vaginalis calmodulin, putative 0.019 0.0413 0.1187
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Trypanosoma cruzi major cysteine proteinase, putative 0.025 0.0555 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0027
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0004 0.0013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0011 0.0011
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0063 0.0111 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0906 0.2108 0.6021
Giardia lamblia Hypothetical protein 0.025 0.0555 0.1597
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0038 0.0109
Echinococcus granulosus cathepsin l cysteine peptidase 0.0811 0.1883 0.1883
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0106 0.0106
Echinococcus granulosus neuronal calcium sensor 0.019 0.0413 0.0413
Plasmodium vivax SET domain protein, putative 0.0061 0.0106 0.0378
Brugia malayi beta-lactamase 0.0038 0.0052 0.0052
Giardia lamblia Serine peptidase, putative 0.002 0.0009 0.0027
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0006
Schistosoma mansoni cathepsin B (C01 family) 0.025 0.0555 0.0555
Brugia malayi Trypsin family protein 0.0083 0.0159 0.0159
Plasmodium falciparum serine repeat antigen 1 0.025 0.0555 0.2947
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0063 0.0111 0.0565
Trypanosoma brucei centrin, putative 0.019 0.0413 0.1179
Onchocerca volvulus 0.0136 0.0285 0.0605
Schistosoma mansoni calpain C (C02 family) 0.1195 0.2792 0.2792
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0811 0.1883 0.5417
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0251 0.1781
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0054 0.0054
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0347 0.0785 0.0785
Brugia malayi PXA domain containing protein 0.0039 0.0054 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0052 0.0168
Brugia malayi Trypsin family protein 0.0083 0.0159 0.0159
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.0002 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0038 0.0038
Leishmania major proteasome beta 2 subunit, putative 0.0039 0.0055 0.0156
Trypanosoma brucei protein I/6 0.019 0.0413 0.1179
Echinococcus multilocularis microtubule associated protein 2 0.1408 0.3296 0.3296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0011 0.0011
Leishmania major calmodulin-like protein 0.019 0.0413 0.1179
Brugia malayi Cathepsin L-like precursor 0.0811 0.1883 0.1883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0811 0.1883 0.5417
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0004 0.0013
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0039 0.0055 0.0055
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0011 0.0023

Activities

Activity type Activity value Assay description Source Reference
pKB (functional) = 6.36 Histamine H2 receptor antagonism at a concentration of 1 micromolar on the isolated guinea pig right atrium. ChEMBL. 1613748
Relative potency (functional) = 91 % Inhibition of the positive chronotropic response (histamine H2 receptor antagonism) of guinea pig right atrium relative to cimetidine. ChEMBL. 1613748
Relative potency (functional) = 91 % Inhibition of the positive chronotropic response (histamine H2 receptor antagonism) of guinea pig right atrium relative to cimetidine. ChEMBL. 1613748

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.