Detailed information for compound 1392309

Basic information

Technical information
  • TDR Targets ID: 1392309
  • Name: 6-(chloromethyl)-N-(3-methylphenyl)-1,3,5-tri azine-2,4-diamine
  • MW: 249.699 | Formula: C11H12ClN5
  • H donors: 2 H acceptors: 3 LogP: 2.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCc1nc(nc(n1)N)Nc1cccc(c1)C
  • InChi: 1S/C11H12ClN5/c1-7-3-2-4-8(5-7)14-11-16-9(6-12)15-10(13)17-11/h2-5H,6H2,1H3,(H3,13,14,15,16,17)
  • InChiKey: RRFIGUHVIZZXQT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [4-amino-6-(chloromethyl)-s-triazin-2-yl]-(3-methylphenyl)amine
  • 6-Chloromethyl-N-m-tolyl-[1,3,5]triazine-2,4-diamine
  • MLS000332359
  • SMR000435021
  • STK134210
  • ZINC00530311
  • ZINC01237529

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nucleotide-binding oligomerization domain containing 1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis calmodulin, putative 0.0559 0.0472 0.143
Brugia malayi Neuronal calcium sensor family protein 1 0.008 0.0042 0.0038
Toxoplasma gondii hypothetical protein 0.1017 0.0883 0.2649
Brugia malayi chromobox protein homolog 3 0.0047 0.0012 0.0009
Schistosoma mansoni calpain (C02 family) 0.353 0.3139 0.3137
Entamoeba histolytica cysteine proteinase, putative 0.0443 0.0367 0.1616
Trypanosoma cruzi conserved protein 0.1017 0.0883 0.0873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Entamoeba histolytica calpain family cysteine protease, putative 0.1017 0.0883 0.3943
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.3713 0.3303 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0077 0.0074
Leishmania major programmed cell death 6 protein-like protein 0.0559 0.0472 0.1401
Giardia lamblia Cathepsin L precursor 0.0373 0.0305 0.0807
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1017 0.0883 0.0873
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.3132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Brugia malayi calpain 5 0.1017 0.0883 0.088
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.1017 0.0883 0.0873
Trichomonas vaginalis kakapo, putative 0.008 0.0042 0.0126
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Schistosoma mansoni caspase-3 (C14 family) 0.0097 0.0057 0.0054
Toxoplasma gondii centrin family protein 0.008 0.0042 0.0093
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0373 0.0305 0.0301
Trypanosoma brucei calpain-like protein, putative 0.353 0.3139 0.9502
Loa Loa (eye worm) hypothetical protein 0.0041 0.0007 0.0004
Brugia malayi cathepsin Z-like cysteine proteinase 0.0373 0.0305 0.0301
Giardia lamblia Cysteine protease 0.0373 0.0305 0.0807
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Giardia lamblia Encystation-specific protease 0.0373 0.0305 0.0807
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0097 0.0057 0.0054
Giardia lamblia Hypothetical protein 0.0566 0.0479 0.134
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1017 0.0883 0.0873
Trypanosoma brucei calpain-like protein, putative 0.353 0.3139 0.9502
Brugia malayi Cathepsin L-like precursor 0.0545 0.0459 0.0456
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Onchocerca volvulus 0.0559 0.0472 0.0886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Trichomonas vaginalis hypothetical protein 0.1017 0.0883 0.2674
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0566 0.0479 0.0475
Onchocerca volvulus 0.008 0.0042 0.0072
Trichomonas vaginalis calpain, putative 0.1017 0.0883 0.2674
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0074 1
Onchocerca volvulus Cathepsin L homolog 0.0545 0.0459 0.0861
Trypanosoma brucei calmodulin, putative 0.0559 0.0472 0.1401
Trypanosoma brucei antigen, putative 0.353 0.3139 0.9502
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0016 0.0012
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0074 1
Plasmodium falciparum centrin-1 0.0559 0.0472 0.5288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0443 0.0367 0.1082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1017 0.0883 0.0873
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0566 0.0479 0.0468
Echinococcus granulosus EF hand domain containing family member A2 0.0559 0.0472 0.0469
Entamoeba histolytica grainin 2 0.008 0.0042 0.0147
Echinococcus granulosus programmed cell death protein 6 0.0087 0.0048 0.0044
Onchocerca volvulus 0.008 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0051 0.0016 0.0013
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0373 0.0305 0.1334
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0443 0.0367 0.0357
Trichomonas vaginalis centrin, putative 0.008 0.0042 0.0126
Schistosoma mansoni reticulocalbin 0.0566 0.0479 0.0475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Schistosoma mansoni centrin 0.0559 0.0472 0.0469
Schistosoma mansoni hypothetical protein 0.1017 0.0883 0.088
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Onchocerca volvulus 0.0475 0.0397 0.0743
Trypanosoma cruzi cysteine protease, putative 0.0443 0.0367 0.0357
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0373 0.0305 0.3368
Plasmodium vivax serine-repeat antigen (SERA) 0.0373 0.0305 0.0939
Echinococcus granulosus calpain A 0.353 0.3139 0.3137
Schistosoma mansoni hypothetical protein 0.0205 0.0154 0.015
Echinococcus multilocularis EF hand domain containing family member A2 0.0559 0.0472 0.0469
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.1017 0.0883 0.2674
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0559 0.0472 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0443 0.0367 0.1112
Schistosoma mansoni myosin light chain 0.008 0.0042 0.0038
Echinococcus granulosus cathepsin L 0.0373 0.0305 0.0301
Brugia malayi EF hand family protein 0.0566 0.0479 0.0475
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0373 0.0305 0.0923
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.0459 0.0449
Loa Loa (eye worm) hypothetical protein 0.0373 0.0305 0.0302
Trypanosoma cruzi cysteine peptidase C (CPC), putative 1.1171 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0033 0.0022
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0559 0.0472 0.0462
Echinococcus granulosus calmodulin 0.0559 0.0472 0.0469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Trypanosoma brucei Calpain-like protein 2 0.1017 0.0883 0.2649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0545 0.0459 0.0456
Plasmodium falciparum serine repeat antigen 5 0.0373 0.0305 0.3368
Schistosoma mansoni rab 0.0559 0.0472 0.0469
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Echinococcus multilocularis cathepsin L cysteine protease 0.0545 0.0459 0.0456
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0373 0.0305 0.0923
Brugia malayi Papain family cysteine protease containing protein 0.0373 0.0305 0.0301
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Loa Loa (eye worm) calpain 0.353 0.3139 0.3137
Trypanosoma cruzi calmodulin, putative 0.0559 0.0472 0.0462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Leishmania major centrin, putative,caltractin, putative 0.0559 0.0472 0.1401
Echinococcus granulosus cathepsin L cysteine proteinase 0.0545 0.0459 0.0456
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0559 0.0472 0.0469
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0373 0.0305 0.0807
Entamoeba histolytica grainin, putative 0.0566 0.0479 0.2118
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.9502
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0373 0.0305 0.0923
Mycobacterium tuberculosis Probable reductase 0.0104 0.0064 0.8342
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.1017 0.0883 0.0873
Echinococcus multilocularis protein dispatched 1 0.0058 0.0022 0.0019
Plasmodium vivax vivapain-2 0.0545 0.0459 0.1433
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Loa Loa (eye worm) hypothetical protein 0.0373 0.0305 0.0302
Echinococcus multilocularis calumenin 0.0566 0.0479 0.0475
Trichomonas vaginalis calcium binding protein, putative 0.0559 0.0472 0.143
Trichomonas vaginalis calmodulin-2, putative 0.0559 0.0472 0.143
Echinococcus multilocularis calpain 7 (C02 family) 0.353 0.3139 0.3137
Loa Loa (eye worm) hypothetical protein 0.007 0.0033 0.0029
Echinococcus multilocularis calbindin 32 0.0566 0.0479 0.0475
Toxoplasma gondii cathepsin CPL 0.0545 0.0459 0.1361
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0373 0.0305 0.0939
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0545 0.0459 0.0456
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.0459 0.0449
Onchocerca volvulus Cell death protein 3 homolog 0.0063 0.0027 0.0045
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.0057 0.0054
Schistosoma mansoni hypothetical protein 0.0043 0.0009 0.0006
Trypanosoma brucei mitochondrial calcium uptake 1 0.0559 0.0472 0.1401
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.1017 0.0883 0.2674
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0305 0.0923
Trypanosoma brucei cysteine peptidase, putative 0.1017 0.0883 0.2649
Loa Loa (eye worm) hypothetical protein 0.9462 0.8466 0.8465
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.9462 0.8466 0.8465
Entamoeba histolytica cysteine protease, putative 0.0373 0.0305 0.1334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Trichomonas vaginalis calmodulin, putative 0.0566 0.0479 0.1449
Loa Loa (eye worm) calmodulin-like protein 0.0559 0.0472 0.0469
Leishmania major cysteine peptidase A (CPA) 0.0545 0.0459 0.1361
Entamoeba histolytica calmodulin, putative 0.0559 0.0472 0.2089
Onchocerca volvulus Cathepsin L homolog 0.0373 0.0305 0.057
Trypanosoma cruzi kinesin, putative 0.2513 0.2226 0.2218
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0373 0.0305 0.0923
Leishmania major calpain family cysteine protease-like protein 0.1017 0.0883 0.2649
Schistosoma mansoni cathepsin F (C01 family) 0.0545 0.0459 0.0456
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.3132
Brugia malayi MH2 domain containing protein 0.0144 0.0099 0.0096
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 1.0022 0.8968 0.8967
Trichomonas vaginalis calmodulin, putative 0.0639 0.0544 0.1646
Schistosoma mansoni cathepsin C 0.0373 0.0305 0.0301
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.1017 0.0883 0.0873
Schistosoma mansoni calmodulin-related 0.008 0.0042 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0373 0.0305 0.0923
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0373 0.0305 0.0301
Schistosoma mansoni hypothetical protein 0.0049 0.0014 0.0011
Giardia lamblia Cathepsin L-like protease 0.0373 0.0305 0.0807
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0007 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0373 0.0305 0.0923
Echinococcus granulosus caspase 3 0.0071 0.0034 0.003
Leishmania major calmodulin, putative 0.0559 0.0472 0.1401
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0012 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0009 0.0006
Plasmodium vivax serine-repeat antigen (SERA) 0.0373 0.0305 0.0939
Loa Loa (eye worm) hypothetical protein 0.5932 0.5296 0.5295
Brugia malayi programmed cell death protein 6 0.0559 0.0472 0.0469
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Onchocerca volvulus 0.0545 0.0459 0.0861
Toxoplasma gondii preprocathepsin c precursor, putative 0.0373 0.0305 0.0892
Brugia malayi Cathepsin L-like cysteine proteinase 0.0475 0.0397 0.0393
Loa Loa (eye worm) cathepsin B 0.3713 0.3303 0.3301
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.353 0.3139 0.3132
Schistosoma mansoni ef hand domain family member A2 0.0559 0.0472 0.0469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0443 0.0367 0.1082
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0373 0.0305 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0373 0.0305 0.0923
Echinococcus multilocularis hypothetical protein 0.353 0.3139 0.3137
Giardia lamblia Cathepsin B precursor 0.3713 0.3303 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0123 0.0119
Trichomonas vaginalis calcium binding protein, putative 0.0639 0.0544 0.1646
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0373 0.0305 0.0301
Schistosoma mansoni neuronal calcium sensor 0.0559 0.0472 0.0469
Echinococcus multilocularis protein patched 0.0051 0.0016 0.0012
Brugia malayi cathepsin Z-like cysteine proteinase 0.0373 0.0305 0.0301
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Loa Loa (eye worm) hypothetical protein 1.1171 1 1
Echinococcus multilocularis cysteine protease 0.0545 0.0459 0.0456
Entamoeba histolytica hypothetical protein 0.0373 0.0305 0.1334
Loa Loa (eye worm) ctsf protein 0.0545 0.0459 0.0456
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.3713 0.3303 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0373 0.0305 0.0301
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Giardia lamblia Cathepsin L precursor 0.0373 0.0305 0.0807
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0024 0.0021
Onchocerca volvulus Cathepsin L homolog 0.0545 0.0459 0.0861
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0046 0.0042
Brugia malayi hypothetical protein 0.0043 0.0009 0.0006
Giardia lamblia Cathepsin L precursor 0.0373 0.0305 0.0807
Plasmodium falciparum calpain 0.1017 0.0883 1
Echinococcus multilocularis calmodulin 0.0559 0.0472 0.0469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0373 0.0305 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.1017 0.0883 0.2674
Entamoeba histolytica cysteine proteinase, putative 0.0443 0.0367 0.1616
Leishmania major hypothetical protein, unknown function 0.1017 0.0883 0.2649
Entamoeba histolytica cysteine protease, putative 0.0545 0.0459 0.203
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0016 0.0023
Leishmania major hypothetical protein, conserved 0.0559 0.0472 0.1401
Brugia malayi Cathepsin L-like precursor 0.0545 0.0459 0.0456
Toxoplasma gondii calcium-dependent protein kinase 0.0566 0.0479 0.142
Leishmania major calpain protease-like protein 0.1017 0.0883 0.2649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0016 0.0012
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1017 0.0883 0.0873
Entamoeba histolytica cysteine proteinase, putative 0.0443 0.0367 0.1616
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0305 0.0923
Giardia lamblia Cathepsin B precursor 0.0373 0.0305 0.0807
Trichomonas vaginalis caltractin, putative 0.008 0.0042 0.0126
Loa Loa (eye worm) hypothetical protein 0.007 0.0033 0.0029
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Schistosoma mansoni cathepsin S (C01 family) 0.0373 0.0305 0.0301
Loa Loa (eye worm) calpain D 0.1017 0.0883 0.088
Trichomonas vaginalis myosin light chain 1, putative 0.0559 0.0472 0.143
Echinococcus granulosus calpain A 1.0029 0.8974 0.8974
Toxoplasma gondii calcium binding protein precursor, putative 0.008 0.0042 0.0093
Loa Loa (eye worm) hypothetical protein 0.008 0.0042 0.0038
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0033 0.0029
Schistosoma mansoni hypothetical protein 0.0049 0.0014 0.0011
Giardia lamblia Cathepsin B precursor 0.3713 0.3303 1
Schistosoma mansoni cathepsin F (C01 family) 0.0545 0.0459 0.0456
Trypanosoma cruzi centrin, putative 0.0639 0.0544 0.0533
Echinococcus multilocularis calpain 5 0.353 0.3139 0.3137
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0064 0.8342
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Echinococcus multilocularis chromobox protein 1 0.0084 0.0046 0.0042
Toxoplasma gondii calmodulin CAM2 0.008 0.0042 0.0093
Loa Loa (eye worm) hypothetical protein 0.0475 0.0397 0.0394
Schistosoma mansoni calpain-7 (C02 family) 0.353 0.3139 0.3137
Trypanosoma brucei calmodulin, putative 0.0566 0.0479 0.142
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0099 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0012 0.0037
Echinococcus granulosus centrin 2 0.0559 0.0472 0.0469
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3713 0.3303 0.3301
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Trichomonas vaginalis calmodulin, putative 0.008 0.0042 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0443 0.0367 0.1112
Trichomonas vaginalis centrin, putative 0.0559 0.0472 0.143
Leishmania major calcineurin B subunit, putative 0.0559 0.0472 0.1401
Brugia malayi Papain family cysteine protease containing protein 0.0373 0.0305 0.0301
Echinococcus granulosus chromobox protein 1 0.0084 0.0046 0.0042
Brugia malayi cathepsin F-like cysteine proteinase 0.007 0.0033 0.0029
Entamoeba histolytica calcium-binding protein, putative 0.0559 0.0472 0.2089
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0559 0.0472 0.0469
Echinococcus granulosus calpain 5 0.353 0.3139 0.3137
Leishmania major calmodulin-like protein 0.0559 0.0472 0.1401
Schistosoma mansoni chromobox protein 0.0084 0.0046 0.0042
Schistosoma mansoni patched 1 0.0051 0.0016 0.0012
Echinococcus multilocularis cathepsin b 1.1171 1 1
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Plasmodium falciparum serine repeat antigen 9 0.0373 0.0305 0.3368
Leishmania major protein kinase, putative 0.0559 0.0472 0.1401
Plasmodium falciparum serine repeat antigen 4 0.0373 0.0305 0.3368
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0373 0.0305 0.0939
Echinococcus granulosus cathepsin b 1.1171 1 1
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0559 0.0472 0.2089
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0475 0.0397 0.1201
Trypanosoma brucei hypothetical protein, conserved 0.0559 0.0472 0.1401
Onchocerca volvulus 0.0373 0.0305 0.057
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 1.1171 1 1
Loa Loa (eye worm) hypothetical protein 0.0545 0.0459 0.0456
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0559 0.0472 0.0462
Toxoplasma gondii cathepsin B 0.3713 0.3303 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0545 0.0459 0.5138
Brugia malayi Cathepsin L-like precursor 0.0475 0.0397 0.0393
Brugia malayi cathepsin L-like precursor 0.0475 0.0397 0.0393
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0012 0.0017
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0373 0.0305 0.0939
Leishmania major calmodulin, putative 0.0559 0.0472 0.1401
Echinococcus granulosus programmed cell death protein 0.0639 0.0544 0.054
Echinococcus multilocularis calpain A 1.0029 0.8974 0.8974
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0373 0.0305 0.0301
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.3132
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3713 0.3303 0.3296
Echinococcus multilocularis cysteine protease 0.0545 0.0459 0.0456
Plasmodium falciparum serine repeat antigen 2 0.0373 0.0305 0.3368
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0373 0.0305 0.0302
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.1017 0.0883 0.2674
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0064 0.8342
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0016 0.0047
Plasmodium vivax vivapain-3 0.0443 0.0367 0.1139
Brugia malayi cathepsin F-like cysteine proteinase 0.0373 0.0305 0.0301
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0545 0.0459 0.0456
Echinococcus multilocularis Myosin regulatory light chain 0.008 0.0042 0.0038
Loa Loa (eye worm) calpain family protein 1 0.9462 0.8466 0.8465
Schistosoma mansoni neuronal calcium sensor 0.0559 0.0472 0.0469
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0042 0.0031
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.0459 0.0449
Brugia malayi Cathepsin L-like precursor 0.0545 0.0459 0.0456
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0099 0.0096
Brugia malayi Papain family cysteine protease containing protein 0.0545 0.0459 0.0456
Echinococcus granulosus cathepsin L cysteine protease 0.0443 0.0367 0.0364
Loa Loa (eye worm) hypothetical protein 0.0559 0.0472 0.0469
Leishmania major i/6 autoantigen-like protein 0.0559 0.0472 0.1401
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0074 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0024 0.0021
Toxoplasma gondii EF hand domain-containing protein 0.0559 0.0472 0.1401
Echinococcus granulosus calbindin 32 0.0566 0.0479 0.0475
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Giardia lamblia Cathepsin B precursor 0.0373 0.0305 0.0807
Entamoeba histolytica calpain large subunit domain III containing protein 0.2513 0.2226 1
Echinococcus granulosus EF hand domain containing family member A2 0.0566 0.0479 0.0475
Plasmodium falciparum serine repeat antigen 8 0.0373 0.0305 0.3368
Leishmania major hypothetical protein, conserved 0.0566 0.0479 0.142
Trypanosoma brucei centrin, putative 0.0559 0.0472 0.1401
Trichomonas vaginalis calmodulin, putative 0.0559 0.0472 0.143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0373 0.0305 0.0923
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0016 0.0013
Brugia malayi RasGEF domain containing protein 0.008 0.0042 0.0038
Trichomonas vaginalis centrin, putative 0.008 0.0042 0.0126
Giardia lamblia Cysteine protease 0.0373 0.0305 0.0807
Schistosoma mansoni cathepsin F (C01 family) 0.0475 0.0397 0.0393
Loa Loa (eye worm) hypothetical protein 0.0062 0.0026 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Echinococcus granulosus cathepsin l1 0.0545 0.0459 0.0456
Echinococcus granulosus chromobox protein 1 0.0084 0.0046 0.0042
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0373 0.0305 0.0939
Leishmania major kinesin, putative 0.2513 0.2226 0.6728
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 1.1171 1 1
Schistosoma mansoni cathepsin s 0.007 0.0033 0.0029
Trypanosoma brucei Component of motile flagella 41 0.0559 0.0472 0.1401
Trichomonas vaginalis calcium binding proteins, putative 0.0559 0.0472 0.143
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Schistosoma mansoni neuronal calcium sensor 0.0559 0.0472 0.0469
Schistosoma mansoni chromobox protein 0.0084 0.0046 0.0042
Trichomonas vaginalis centrin, putative 0.0559 0.0472 0.143
Plasmodium falciparum serine repeat antigen 3 0.0373 0.0305 0.3368
Brugia malayi Cathepsin L-like precursor 0.0545 0.0459 0.0456
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0559 0.0472 0.0462
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.1017 0.0883 0.2649
Schistosoma mansoni hypothetical protein 0.0559 0.0472 0.0469
Trichomonas vaginalis calcineurin B subunit, putative 0.0566 0.0479 0.1449
Brugia malayi Cell death protein 3 precursor 0.0063 0.0027 0.0023
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0077 0.0073
Trypanosoma brucei caltractin, putative 0.0639 0.0544 0.1618
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0078 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Leishmania major hypothetical protein, conserved 0.1017 0.0883 0.2649
Toxoplasma gondii troponin c, isotype gamma, putative 0.0559 0.0472 0.1401
Echinococcus multilocularis programmed cell death protein 6 0.0087 0.0048 0.0044
Loa Loa (eye worm) hypothetical protein 0.0373 0.0305 0.0302
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1017 0.0883 0.0873
Plasmodium vivax vivapain-1 0.0443 0.0367 0.1139
Echinococcus granulosus calpain 7 C02 family 0.353 0.3139 0.3137
Toxoplasma gondii calmodulin CAM1 0.0566 0.0479 0.142
Brugia malayi calpain D 0.1017 0.0883 0.088
Trichomonas vaginalis calmodulin, putative 0.0559 0.0472 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Plasmodium vivax unspecified product 0.0443 0.0367 0.1139
Entamoeba histolytica protein kinase, putative 0.2513 0.2226 1
Trypanosoma brucei centrin-3 0.0639 0.0544 0.1618
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0373 0.0305 0.0301
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Schistosoma mansoni calmodulin 0.0559 0.0472 0.0469
Brugia malayi calpain family protein 1 0.9462 0.8466 0.8465
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.3132
Giardia lamblia Cathepsin L precursor 0.0373 0.0305 0.0807
Schistosoma mansoni hypothetical protein 0.0041 0.0007 0.0003
Loa Loa (eye worm) myosin Light Chain family member 0.0087 0.0048 0.0045
Leishmania major centrin, putative 0.0559 0.0472 0.1401
Schistosoma mansoni myosin regulatory light chain 0.008 0.0042 0.0038
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0373 0.0305 0.0301
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0077 0.0073
Schistosoma mansoni hypothetical protein 0.0559 0.0472 0.0469
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.007 0.0033 0.0029
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0559 0.0472 0.0462
Trichomonas vaginalis calmodulin, putative 0.0559 0.0472 0.143
Echinococcus multilocularis cathepsin L 0.0443 0.0367 0.0364
Echinococcus granulosus cathepsin b 1.1171 1 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.353 0.3139 0.3137
Trypanosoma cruzi calpain cysteine peptidase, putative 0.353 0.3139 0.3132
Schistosoma mansoni calmodulin 0.0559 0.0472 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Loa Loa (eye worm) calpain family protein 1 0.6949 0.6209 0.6208
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.9502
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0545 0.0459 0.5138
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0046 0.0138
Echinococcus granulosus expressed conserved protein 0.0112 0.007 0.0067
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Onchocerca volvulus 0.0566 0.0479 0.0898
Loa Loa (eye worm) hypothetical protein 0.6949 0.6209 0.6208
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.008 0.0042 0.0126
Entamoeba histolytica calmodulin, putative 0.0559 0.0472 0.2089
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0559 0.0472 0.0462
Onchocerca volvulus 0.0545 0.0459 0.0861
Onchocerca volvulus 0.0559 0.0472 0.0886
Loa Loa (eye worm) calpain 5 0.2513 0.2226 0.2224
Toxoplasma gondii cathepsin CPC1 0.0373 0.0305 0.0892
Loa Loa (eye worm) hypothetical protein 0.008 0.0042 0.0038
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Brugia malayi Cathepsin L-like precursor 0.0545 0.0459 0.0456
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0545 0.0459 0.0456
Trichomonas vaginalis caltractin, putative 0.008 0.0042 0.0126
Echinococcus multilocularis cathepsin L cysteine protease 0.0545 0.0459 0.0456
Loa Loa (eye worm) hypothetical protein 0.0373 0.0305 0.0302
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0559 0.0472 0.143
Onchocerca volvulus Cathepsin F homolog 0.0545 0.0459 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0012 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Trypanosoma brucei protein I/6 0.0559 0.0472 0.1401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0373 0.0305 0.0807
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Brugia malayi fibroinase precursor 0.0373 0.0305 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0443 0.0367 0.0364
Echinococcus multilocularis programmed cell death protein 0.0639 0.0544 0.054
Giardia lamblia Cysteine protease 0.0373 0.0305 0.0807
Entamoeba histolytica cysteine protease, putative 0.0373 0.0305 0.1334
Toxoplasma gondii EFHC1, putative 0.0559 0.0472 0.1401
Brugia malayi calpain 5 0.2513 0.2226 0.2223
Echinococcus granulosus cysteine protease 0.0443 0.0367 0.0364
Trypanosoma cruzi centrin-3 0.0639 0.0544 0.0533
Echinococcus granulosus cathepsin l1 0.0475 0.0397 0.0393
Loa Loa (eye worm) hypothetical protein 0.0373 0.0305 0.0302
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0373 0.0305 0.0807
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Toxoplasma gondii centrin, putative 0.0559 0.0472 0.1401
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Entamoeba histolytica cysteine proteinase, putative 0.0545 0.0459 0.203
Schistosoma mansoni centrin-related 0.0559 0.0472 0.0469
Brugia malayi calpain 7 0.353 0.3139 0.3137
Trypanosoma brucei Calpain-like protein 1.1 0.1017 0.0883 0.2649
Toxoplasma gondii calmodulin, putative 0.008 0.0042 0.0093
Giardia lamblia Hypothetical protein 0.0373 0.0305 0.0807
Plasmodium vivax calpain, putative 0.353 0.3139 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0046 0.0138
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.1017 0.0883 0.2649
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.9502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Entamoeba histolytica cysteine proteinase, putative 0.0443 0.0367 0.1616
Giardia lamblia Cathepsin B precursor 0.0373 0.0305 0.0807
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0443 0.0367 0.0364
Plasmodium vivax hypothetical protein, conserved 0.0566 0.0479 0.1495
Brugia malayi Calmodulin-like protein 0.0559 0.0472 0.0469
Echinococcus granulosus neurocalcin 0.0559 0.0472 0.0469
Brugia malayi Cathepsin L-like precursor 0.007 0.0033 0.0029
Onchocerca volvulus 0.0545 0.0459 0.0861
Trichomonas vaginalis centrin, putative 0.008 0.0042 0.0126
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Trichomonas vaginalis conserved hypothetical protein 0.0559 0.0472 0.143
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 1.0022 0.8968 0.8967
Plasmodium vivax centrin-1, putative 0.0559 0.0472 0.1474
Echinococcus granulosus calcium uptake protein 1 0.0566 0.0479 0.0475
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0373 0.0305 0.0301
Schistosoma mansoni calpain-2 (C02 family) 0.1017 0.0883 0.088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0559 0.0472 0.1474
Echinococcus multilocularis calpain family protein 1, d 0.6949 0.6209 0.6208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Brugia malayi Myosin regulatory light chain 1 0.008 0.0042 0.0038
Brugia malayi CHE-14 protein 0.0051 0.0016 0.0012
Trichomonas vaginalis calmodulin, putative 0.0559 0.0472 0.143
Echinococcus granulosus caspase 2 0.0063 0.0027 0.0023
Schistosoma mansoni calpain-7 (C02 family) 0.353 0.3139 0.3137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Trypanosoma brucei centrin, putative 0.0559 0.0472 0.1401
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0373 0.0305 0.3368
Echinococcus granulosus cathepsin L 0.0443 0.0367 0.0364
Entamoeba histolytica cysteine proteinase, putative 0.0545 0.0459 0.203
Entamoeba histolytica grainin 2 0.0639 0.0544 0.2412
Plasmodium falciparum centrin-4 0.008 0.0042 0.035
Trypanosoma cruzi cysteine peptidase, putative 0.0545 0.0459 0.0449
Echinococcus multilocularis cathepsin b 1.1171 1 1
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.008 0.0042 0.0072
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0373 0.0305 0.1334
Trypanosoma cruzi major cysteine proteinase, putative 0.0373 0.0305 0.0294
Schistosoma mansoni calpain C (C02 family) 0.353 0.3139 0.3137
Giardia lamblia Cathepsin B precursor 0.3713 0.3303 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0475 0.0397 0.0386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Onchocerca volvulus 0.0545 0.0459 0.0861
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Echinococcus granulosus caspase 0.0097 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.0063 0.0027 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Entamoeba histolytica cysteine proteinase, putative 0.0475 0.0397 0.1748
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.1017 0.0883 0.2674
Brugia malayi Papain family cysteine protease containing protein 0.0373 0.0305 0.0301
Schistosoma mansoni mitochondrial solute carrier 0.0559 0.0472 0.0469
Loa Loa (eye worm) myosin regulatory light chain 1 0.008 0.0042 0.0038
Brugia malayi EF hand family protein 0.0559 0.0472 0.0469
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Echinococcus multilocularis calpain 0.353 0.3139 0.3137
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0009 0.0006
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0077 0.0073
Leishmania major phospholipase c-like protein 0.0559 0.0472 0.1401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Plasmodium vivax vivapain-2 0.0545 0.0459 0.1433
Trichomonas vaginalis calmodulin, putative 0.0559 0.0472 0.143
Schistosoma mansoni hypothetical protein 0.0205 0.0154 0.015
Echinococcus multilocularis caspase 2 0.0063 0.0027 0.0023
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Trypanosoma cruzi cysteine peptidase, putative 0.0443 0.0367 0.0357
Brugia malayi Papain family cysteine protease containing protein 0.0443 0.0367 0.0364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Trypanosoma brucei Calpain-like protein CALP1.3 0.1017 0.0883 0.2649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0373 0.0305 0.0923
Echinococcus multilocularis caspase 3 0.0071 0.0034 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Toxoplasma gondii cathepsin CPC2 0.0373 0.0305 0.0892
Loa Loa (eye worm) hypothetical protein 0.0475 0.0397 0.0394
Loa Loa (eye worm) programmed cell death protein 6 0.0566 0.0479 0.0476
Trypanosoma cruzi calmodulin, putative 0.0559 0.0472 0.0462
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0373 0.0305 0.0302
Trypanosoma cruzi caltractin, putative 0.0559 0.0472 0.0462
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.353 0.3139 0.9502
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0373 0.0305 0.0939
Echinococcus multilocularis neuronal calcium sensor 0.0559 0.0472 0.0469
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0559 0.0472 0.1401
Loa Loa (eye worm) hypothetical protein 0.0373 0.0305 0.0302
Echinococcus multilocularis programmed cell death protein 0.0639 0.0544 0.054
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0064 0.8342
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0373 0.0305 0.0301
Trypanosoma brucei Calpain-like protein 1.2 0.1017 0.0883 0.2649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0373 0.0305 0.0923
Brugia malayi Papain family cysteine protease containing protein 0.0443 0.0367 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0475 0.0397 0.1201
Brugia malayi cathepsin L precursor 0.0373 0.0305 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0545 0.0459 0.139
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.1017 0.0883 0.2674
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0123 0.0119
Brugia malayi Cathepsin L-like precursor 0.0475 0.0397 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0373 0.0305 0.0923
Echinococcus multilocularis calcium uptake protein 1 0.0566 0.0479 0.0475
Toxoplasma gondii EF hand domain-containing protein 0.008 0.0042 0.0093
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0559 0.0472 0.1401
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.1017 0.0883 0.2674
Giardia lamblia Hypothetical protein 0.0373 0.0305 0.0807
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0559 0.0472 0.2089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0545 0.0459 0.1361
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1017 0.0883 0.0873
Echinococcus granulosus EF HAND 1 calcium binding site 0.0559 0.0472 0.0469
Brugia malayi Heterochromatin protein 1 0.0084 0.0046 0.0042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0443 0.0367 0.0364
Schistosoma mansoni SmCB2 peptidase (C01 family) 1.1171 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0024 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0545 0.0459 0.139
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1017 0.0883 0.0873
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.353 0.3139 0.3132
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0373 0.0305 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0048
Leishmania major centrin, putative 0.0559 0.0472 0.1401
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0373 0.0305 0.0302
Schistosoma mansoni hypothetical protein 0.0049 0.0014 0.0011
Loa Loa (eye worm) glutathione reductase 0.0046 0.0011 0.0008
Echinococcus granulosus geminin 0.0205 0.0154 0.015
Trypanosoma cruzi I/6 autoantigen, putative 0.0559 0.0472 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0373 0.0305 0.0923
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0373 0.0305 0.0939
Entamoeba histolytica cysteine protease, putative 0.0443 0.0367 0.1616
Schistosoma mansoni reticulocalbin 0.0559 0.0472 0.0469
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0016 0.0047
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.353 0.3139 0.3132
Echinococcus multilocularis calmodulin 0.0559 0.0472 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0042 0.0126
Schistosoma mansoni myosin regulatory light chain 0.008 0.0042 0.0038
Trypanosoma cruzi cysteine proteinase, putative 0.0443 0.0367 0.0357
Loa Loa (eye worm) hypothetical protein 0.1017 0.0883 0.088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.0459 0.139
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1017 0.0883 0.2649
Plasmodium vivax unspecified product 0.0373 0.0305 0.0939
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0373 0.0305 0.3368
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Echinococcus multilocularis chromobox protein 1 0.0084 0.0046 0.0042
Trypanosoma cruzi cruzipain precursor, putative 0.0545 0.0459 0.0449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0373 0.0305 0.0923
Brugia malayi Thioredoxin reductase 0.0046 0.0011 0.0008
Entamoeba histolytica cysteine protease, putative 0.0373 0.0305 0.1334
Trypanosoma cruzi major cysteine proteinase, putative 0.0373 0.0305 0.0294
Trypanosoma cruzi centrin, putative 0.0639 0.0544 0.0533
Trypanosoma cruzi kinesin, putative 0.2513 0.2226 0.2218
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Brugia malayi calpain family protein 1 0.9462 0.8466 0.8465
Entamoeba histolytica cysteine protease, putative 0.0373 0.0305 0.1334
Plasmodium falciparum serine repeat antigen 1 0.0373 0.0305 0.3368
Echinococcus granulosus calpain 0.353 0.3139 0.3137
Entamoeba histolytica hypothetical protein, conserved 0.0566 0.0479 0.2118
Trichomonas vaginalis calpain, putative 0.1017 0.0883 0.2674
Trypanosoma brucei hypothetical protein 0.1017 0.0883 0.2649
Giardia lamblia Cathepsin L precursor 0.0373 0.0305 0.0807
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.008 0.0042 0.0097
Onchocerca volvulus 0.0037 0.0004 0.0001
Schistosoma mansoni neuronal calcium sensor 0.0559 0.0472 0.0469
Loa Loa (eye worm) hypothetical protein 0.008 0.0042 0.0038
Echinococcus granulosus family C2 unassigned peptidase C02 family 1.0022 0.8968 0.8967
Giardia lamblia Cathepsin L-like protease 0.0373 0.0305 0.0807
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0033 0.0022
Entamoeba histolytica cysteine protease, putative 0.0373 0.0305 0.1334
Trichomonas vaginalis calmodulin, putative 0.0559 0.0472 0.143
Echinococcus multilocularis calcyphosin protein 0.008 0.0042 0.0038
Plasmodium falciparum serine repeat antigen 7 0.0373 0.0305 0.3368
Onchocerca volvulus 0.0545 0.0459 0.0861
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0016 0.0012
Brugia malayi calcium-binding protein 0.0559 0.0472 0.0469
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0074 1
Echinococcus granulosus Calcium binding protein 0.008 0.0042 0.0038
Leishmania major calmodulin-like protein 0.0559 0.0472 0.1401
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.353 0.3139 0.3132
Loa Loa (eye worm) EF hand family protein 0.0559 0.0472 0.0469
Echinococcus multilocularis neurocalcin 0.0559 0.0472 0.0469
Loa Loa (eye worm) hypothetical protein 0.007 0.0033 0.0029
Trichomonas vaginalis calcineurin B subunit, putative 0.0559 0.0472 0.143
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.353 0.3139 0.9502
Plasmodium vivax unspecified product 0.007 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0559 0.0472 0.0469
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 1.1171 1 1
Brugia malayi glutathione reductase 0.0046 0.0011 0.0008
Trypanosoma brucei calpain, putative 0.1017 0.0883 0.2649
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0373 0.0305 0.0923
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0545 0.0459 0.5138
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.353 0.3139 0.3132
Echinococcus granulosus cathepsin l cysteine peptidase 0.0545 0.0459 0.0456
Echinococcus multilocularis geminin 0.0205 0.0154 0.015
Schistosoma mansoni cathepsin B (C01 family) 0.0373 0.0305 0.0301
Toxoplasma gondii centrin 0.0559 0.0472 0.1401
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0064 0.8342
Entamoeba histolytica cysteine proteinase 1, putative 0.0443 0.0367 0.1616
Echinococcus multilocularis centrin 2 0.0559 0.0472 0.0469
Entamoeba histolytica cysteine protease, putative 0.0373 0.0305 0.1334
Trypanosoma brucei calpain-like protein, putative 0.353 0.3139 0.9502
Leishmania major cathepsin L-like protease 0.0545 0.0459 0.1361
Trichomonas vaginalis calpain, putative 0.1017 0.0883 0.2674
Echinococcus multilocularis cathepsin L 0.0373 0.0305 0.0301
Trypanosoma cruzi I/6 autoantigen, putative 0.0559 0.0472 0.0462
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0559 0.0472 0.0469
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0373 0.0305 0.0939
Giardia lamblia Cathepsin B precursor 0.0373 0.0305 0.0807
Entamoeba histolytica calcium binding family protein 0.0559 0.0472 0.2089
Echinococcus multilocularis caspase 0.0097 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.8445 0.7552 0.7552
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.2649
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0559 0.0472 0.0469
Trypanosoma brucei calpain-like protein, putative 0.353 0.3139 0.9502
Onchocerca volvulus 0.5932 0.5296 1
Giardia lamblia Cysteine protease 0.0373 0.0305 0.0807
Echinococcus granulosus neuronal calcium sensor 0.0559 0.0472 0.0469
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0373 0.0305 0.0939
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0064 0.8342
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0011 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0373 0.0305 0.0923
Schistosoma mansoni calmodulin related calcium binding protein 0.0559 0.0472 0.0469
Trypanosoma brucei I/6 autoantigen 0.0559 0.0472 0.1401
Giardia lamblia Cathepsin B precursor 0.0373 0.0305 0.0807
Trichomonas vaginalis calcium binding protein, putative 0.008 0.0042 0.0126
Brugia malayi Probable myosin regulatory light chain 0.0087 0.0048 0.0044
Trypanosoma brucei cysteine peptidase C (CPC) 0.3713 0.3303 1
Onchocerca volvulus 0.0545 0.0459 0.0861
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 1.0022 0.8968 0.8967
Trypanosoma cruzi cysteine proteinase, putative 0.0443 0.0367 0.0357
Loa Loa (eye worm) cysteine protease 0.0545 0.0459 0.0456
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0373 0.0305 0.0807
Giardia lamblia Cathepsin L precursor 0.0373 0.0305 0.0807
Trypanosoma brucei calpain, putative 0.1017 0.0883 0.2649
Onchocerca volvulus 0.0545 0.0459 0.0861
Schistosoma mansoni hypothetical protein 0.0049 0.0014 0.0011
Trypanosoma brucei kinesin, putative 0.2513 0.2226 0.6728
Schistosoma mansoni caspase-7 (C14 family) 0.0063 0.0027 0.0023
Echinococcus multilocularis Calcium binding protein 0.008 0.0042 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0545 0.0459 0.139
Loa Loa (eye worm) fibroinase 0.0545 0.0459 0.0456
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0077 0.0306
Plasmodium falciparum cysteine proteinase falcipain 1 0.0443 0.0367 0.4086
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0009 0.0006
Brugia malayi cathepsin L-like cysteine proteinase 0.0373 0.0305 0.0301
Trichomonas vaginalis calcium binding protein, putative 0.0559 0.0472 0.143
Plasmodium falciparum serine repeat antigen 6 0.0373 0.0305 0.3368
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.1017 0.0883 0.2649
Trichomonas vaginalis conserved hypothetical protein 0.0559 0.0472 0.143
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1017 0.0883 0.0873
Echinococcus granulosus calumenin 0.0566 0.0479 0.0475
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0024 0.0021
Trypanosoma cruzi calmodulin, putative 0.0559 0.0472 0.0462
Echinococcus multilocularis expressed conserved protein 0.0112 0.007 0.0067
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0097 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.0475 0.0397 0.0394
Echinococcus granulosus calcyphosin protein 0.008 0.0042 0.0038
Echinococcus multilocularis EF hand domain containing family member A2 0.0566 0.0479 0.0475
Entamoeba histolytica cysteine proteinase 2 0.0443 0.0367 0.1616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0373 0.0305 0.0923
Echinococcus granulosus Myosin regulatory light chain 0.008 0.0042 0.0038
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0373 0.0305 0.0939
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.008 0.0042 0.0072
Brugia malayi Cathepsin L-like precursor 0.0545 0.0459 0.0456
Trichomonas vaginalis calcium binding protein, putative 0.0559 0.0472 0.143
Entamoeba histolytica calmodulin, putative 0.008 0.0042 0.0147

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 6.826 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 7.741 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 8.71 uM PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD1. uHTS luminescence assay for the identification of compounds that inhibit NOD1, utilizing an NF-kB-mediated luciferase reporter gene activity as a measure of NOD1 modulation (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1849, AID1852, AID2250, AID2255, AID2260, AID2261, AID2264, AID2333, AID2334, AID2335, AID2337, AID2466, AID2469, AID2475, AID2483, AID2485, AID2503, AID2505, AID2789, AID2792, AID2793, AID2798, AID2799, AID2800, AID2801] ChEMBL. No reference
EC50 (functional) = 24.4 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1554, AID1674] ChEMBL. No reference
EC50 (functional) > 75 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 4.54 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2335, AID2466, AID2469, AID2505, AID2798, AID2800] ChEMBL. No reference
IC50 (functional) = 9.202 uM PUBCHEM_BIOASSAY: HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2337] ChEMBL. No reference
IC50 (functional) = 10.23 uM PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID1849, AID2260, AID2335, AID2469, AID2503, AID2800] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2469, AID2483, AID2485, AID2800, AID2801] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD1 cell inhibition assay. Cytotoxicity counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2466, AID2469, AID2475, AID2503, AID2793, AID2798, AID2799, AID2800] ChEMBL. No reference
IC50 (functional) > 50 um PUBCHEM_BIOASSAY: Thrombin 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 1046 (Thrombin 1536 HTS; hits were confirmed in this assay)] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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