Detailed information for compound 1392442

Basic information

Technical information
  • TDR Targets ID: 1392442
  • Name: NCGC00074615-01
  • MW: 627.707 | Formula: C33H45F4NO6
  • H donors: 0 H acceptors: 1 LogP: 4.63 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCC1C2CC[C@@H]3[C@@H]4C2=C([C@@H](C1COC)C)CN([C@]4(C)COC3OCc1ccc(cc1C(F)(F)F)F)C(=O)OC(C)(C)C
  • InChi: 1S/C33H45F4NO6/c1-18-23-13-38(30(39)44-31(2,3)4)32(5)17-43-29(42-14-19-8-9-20(34)12-26(19)33(35,36)37)22-11-10-21(27(23)28(22)32)25(16-41-7)24(18)15-40-6/h8-9,12,18,21-22,24-25,28-29H,10-11,13-17H2,1-7H3/t18-,21?,22+,24?,25?,28+,29?,32+/m0/s1
  • InChiKey: DUKJYOYRVFEOOI-MZKYGMSNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CMLD1_000318
  • SDCCGMLS-0091635.P001
  • UPCMLD00CCLH1-045

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major proteasome beta-1 subunit, putative 0.003 0.035 0.0407
Onchocerca volvulus Notchless protein homolog 0.003 0.035 0.0133
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0335 0.0225
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.003 0.035 0.0195
Toxoplasma gondii calmodulin CAM1 0.0028 0.0307 0.076
Echinococcus granulosus calpain 7 C02 family 0.0184 0.3402 0.3402
Brugia malayi proteasome subunit beta type 3 0.003 0.035 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus granulosus gamma secretase subunit aph 1 0.0143 0.2591 0.2591
Loa Loa (eye worm) proteasome subunit alpha type 1 0.003 0.035 0.0371
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.1555 0.172
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Schistosoma mansoni calpain-2 (C02 family) 0.0055 0.0844 0.074
Trypanosoma cruzi kinesin, putative 0.0129 0.2302 0.2665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Loa Loa (eye worm) calpain 0.0184 0.3402 0.3604
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0335 0.0225
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0074 0.121 0.2482
Echinococcus granulosus EF hand domain containing family member A2 0.0028 0.0307 0.0307
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0143 0.2591 0.2746
Brugia malayi Cathepsin L-like precursor 0.0065 0.1037 0.1098
Giardia lamblia 20S proteasome alpha subunit 4 0.003 0.035 0.0195
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Plasmodium vivax serine-repeat antigen (SERA) 0.0027 0.0277 0.0035
Brugia malayi gamma-secretase subunit aph-1 0.0143 0.2591 0.2746
Trypanosoma brucei Calpain-like protein 1.1 0.0055 0.0844 0.1693
Loa Loa (eye worm) hypothetical protein 0.0028 0.0299 0.0316
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.003 0.035 0.0603
Echinococcus granulosus calpain 5 0.0184 0.3402 0.3402
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0028 0.0299 0.0133
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Echinococcus multilocularis calpain family protein 1, d 0.0359 0.6881 0.6881
Onchocerca volvulus 0.0091 0.1555 0.2322
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0795 0.076
Brugia malayi Proteasome A-type and B-type family protein 0.0216 0.4038 0.4279
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.003 0.035 0.0229
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Giardia lamblia Proteasome subunit beta type 2 0.0074 0.121 0.2482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Brugia malayi cathepsin L precursor 0.0027 0.0277 0.0293
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0055 0.0844 0.2091
Loa Loa (eye worm) cathepsin B 0.0149 0.2698 0.2859
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus multilocularis calbindin 32 0.0028 0.0307 0.0307
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0028 0.0299 0.0473
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0184 0.3402 0.8344
Entamoeba histolytica calmodulin, putative 0.0028 0.0299 0.0473
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Plasmodium vivax proteasome subunit alpha type-7, putative 0.003 0.035 0.0229
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0263 0.0088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0299 0.0316
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0184 0.3402 0.4054
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.003 0.035 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0074 0.121 0.121
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.003 0.035 0.024
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Toxoplasma gondii preprocathepsin c precursor, putative 0.0027 0.0277 0.0685
Leishmania major proteasome alpha 1 subunit, putative 0.003 0.035 0.0407
Echinococcus multilocularis calumenin 0.0028 0.0307 0.0307
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0335 0.083
Plasmodium vivax unspecified product 0.0053 0.0795 0.1408
Leishmania major proteasome beta 7 subunit, putative 0.003 0.035 0.0407
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0515 0.9992 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.1555 0.3342
Plasmodium vivax proteasome subunit beta type-2, putative 0.0074 0.121 0.2509
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Schistosoma mansoni hypothetical protein 0.0028 0.0299 0.0188
Leishmania major proteasome beta 2 subunit, putative 0.0074 0.121 0.2645
Entamoeba histolytica protein kinase, putative 0.0129 0.2302 0.5577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0795 0.1564
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.003 0.035 0.035
Echinococcus multilocularis Proteasome subunit alpha type 7 0.003 0.035 0.035
Leishmania major i/6 autoantigen-like protein 0.0028 0.0299 0.0274
Plasmodium vivax vivapain-3 0.0053 0.0795 0.1408
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.003 0.035 0.0195
Leishmania major hypothetical protein, conserved 0.0055 0.0844 0.1693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0078 0.1291 0.1291
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0113 0.0113
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0078 0.1291 0.1387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0027 0.0277 0.0165
Onchocerca volvulus 0.0028 0.0299 0.004
Echinococcus granulosus Proteasome subunit alpha type 7 0.003 0.035 0.035
Trypanosoma cruzi I/6 autoantigen, putative 0.0028 0.0299 0.0133
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0299 0.0274
Toxoplasma gondii proteasome subunit alpha1, putative 0.003 0.035 0.0866
Echinococcus granulosus cathepsin l cysteine peptidase 0.0091 0.1555 0.1555
Echinococcus multilocularis programmed cell death protein 0.0028 0.0299 0.0299
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0113 0.012
Loa Loa (eye worm) hypothetical protein 0.0091 0.1555 0.1647
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0027 0.0277 0.0379
Brugia malayi hypothetical protein 0.0146 0.2646 0.2804
Loa Loa (eye worm) PAS-3 protein 0.003 0.035 0.0371
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0695 0.0589
Leishmania major proteasome alpha 3 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.003 0.035 0.0603
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.1555 0.1555
Echinococcus granulosus cathepsin l1 0.0091 0.1555 0.1555
Trypanosoma cruzi major cysteine proteinase, putative 0.0072 0.118 0.1247
Brugia malayi Cytochrome P450 family protein 0.0023 0.0193 0.0205
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma cruzi Aph-1 protein, putative 0.0056 0.0854 0.0835
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.3859 0.4088
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.003 0.035 0.0866
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Echinococcus granulosus neuronal calcium sensor 0.0028 0.0299 0.0299
Trypanosoma brucei proteasome alpha 7 subunit 0.003 0.035 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0795 0.1564
Entamoeba histolytica cysteine proteinase 2 0.0053 0.0795 0.1737
Toxoplasma gondii centrin, putative 0.0028 0.0299 0.0739
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0028 0.0299 0.0133
Plasmodium vivax vivapain-2 0.0091 0.1555 0.3421
Schistosoma mansoni calpain-7 (C02 family) 0.0184 0.3402 0.3329
Trypanosoma cruzi kinesin, putative 0.0129 0.2302 0.2665
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.003 0.035 0.0407
Loa Loa (eye worm) hypothetical protein 0.0421 0.8107 0.859
Echinococcus multilocularis cathepsin b 0.0421 0.8107 0.8107
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Echinococcus multilocularis proteasome (prosome, macropain) 0.0216 0.4038 0.4038
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0945 0.1956
Toxoplasma gondii cathepsin B 0.0149 0.2698 0.6682
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0844 0.1695
Trypanosoma brucei Calpain-like protein 2 0.0055 0.0844 0.1693
Brugia malayi Proteasome subunit alpha type 7-1 0.003 0.035 0.0371
Echinococcus granulosus Proteasome subunit alpha beta 0.003 0.035 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Brugia malayi Pre-SET motif family protein 0.0207 0.3859 0.4088
Plasmodium vivax proteasome subunit alpha type-2, putative 0.003 0.035 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Brugia malayi calpain 7 0.0184 0.3402 0.3604
Loa Loa (eye worm) proteasome subunit alpha type 6 0.003 0.035 0.0371
Echinococcus granulosus calmodulin 0.0028 0.0299 0.0299
Trypanosoma cruzi caltractin, putative 0.0028 0.0299 0.0133
Trypanosoma brucei proteasome beta-1 subunit, putative 0.003 0.035 0.0407
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0027 0.0277 0.0035
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.003 0.035 0.024
Toxoplasma gondii centrin 0.0028 0.0299 0.0739
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0028 0.0299 0.0094
Echinococcus multilocularis cathepsin L 0.0027 0.0277 0.0277
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0027 0.0277 0.0035
Leishmania major centrin, putative 0.0028 0.0299 0.0274
Trypanosoma cruzi 20S proteasome subunit 0.0074 0.121 0.1285
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0028 0.0307 0.0143
Echinococcus granulosus expressed protein 0.036 0.6912 0.6912
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.003 0.035 0.0198
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Trichomonas vaginalis calpain, putative 0.0055 0.0844 0.1695
Onchocerca volvulus 0.0091 0.1555 0.2322
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0053 0.0795 0.076
Plasmodium vivax proteasome subunit beta type-6, putative 0.003 0.035 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0027 0.0277 0.0379
Loa Loa (eye worm) hypothetical protein 0.0359 0.6881 0.7291
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0216 0.4038 1
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2458 0.2862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0027 0.0277 0.0165
Brugia malayi proteasome subunit alpha type 2 0.003 0.035 0.0371
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.1555 0.1459
Entamoeba histolytica cysteine proteinase 1, putative 0.0053 0.0795 0.1737
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Giardia lamblia Proteasome subunit beta type 3 0.003 0.035 0.0195
Plasmodium vivax vivapain-2 0.0091 0.1555 0.3421
Trypanosoma brucei proteasome beta 7 subunit 0.003 0.035 0.0407
Brugia malayi fibroinase precursor 0.0027 0.0277 0.0293
Leishmania major cathepsin L-like protease 0.0136 0.2458 0.5891
Leishmania major proteasome alpha 7 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis set domain proteins, putative 0.0235 0.4427 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Loa Loa (eye worm) hypothetical protein 0.0438 0.8448 0.8951
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0299 0.043
Schistosoma mansoni calpain C (C02 family) 0.0184 0.3402 0.3329
Brugia malayi proteasome subunit alpha type 4 0.003 0.035 0.0371
Giardia lamblia 20S proteasome alpha subunit 1 0.003 0.035 0.0195
Plasmodium vivax centrin-1, putative 0.0028 0.0299 0.0094
Plasmodium falciparum proteasome subunit beta type-6, putative 0.003 0.035 0.0195
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Schistosoma mansoni mitochondrial solute carrier 0.0028 0.0299 0.0188
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.0823
Trichomonas vaginalis myosin light chain 1, putative 0.0028 0.0299 0.043
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Loa Loa (eye worm) hypothetical protein 0.0146 0.2646 0.2804
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2458 0.2862
Leishmania major hypothetical protein, conserved 0.0028 0.0307 0.0295
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Loa Loa (eye worm) calpain D 0.0055 0.0844 0.0895
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.003 0.035 0.0866
Plasmodium vivax calpain, putative 0.0184 0.3402 0.8313
Plasmodium falciparum cysteine proteinase falcipain 1 0.0053 0.0795 0.1378
Echinococcus granulosus calcium uptake protein 1 0.0028 0.0307 0.0307
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0945 0.2341
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Loa Loa (eye worm) AStacin protease 0.0025 0.0239 0.0254
Toxoplasma gondii cathepsin CPL 0.0091 0.1555 0.385
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Echinococcus granulosus centrin 2 0.0028 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.2698 0.5993
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0277 0.0379
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0113 0.0113
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0113 0.0113
Echinococcus multilocularis expressed protein 0.036 0.6912 0.6912
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.003 0.035 0.024
Giardia lamblia Proteasome subunit beta type 9 precursor 0.003 0.035 0.0195
Plasmodium vivax proteasome subunit alpha type-1, putative 0.003 0.035 0.0229
Plasmodium falciparum proteasome subunit beta type-5 0.0216 0.4038 1
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.003 0.035 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Onchocerca volvulus 0.0091 0.1555 0.2322
Brugia malayi Calmodulin-like protein 0.0028 0.0299 0.0316
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.003 0.035 0.0866
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.003 0.035 0.024
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0487 0.9438 0.944
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0027 0.0277 0.0165
Toxoplasma gondii proteasome subunit 0.003 0.035 0.0866
Entamoeba histolytica proteasome subunit beta type 3, putative 0.003 0.035 0.0603
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0028 0.0299 0.0299
Trichomonas vaginalis hypothetical protein 0.0055 0.0844 0.1695
Onchocerca volvulus 0.0304 0.5782 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0113 0.012
Echinococcus multilocularis hypothetical protein 0.0184 0.3402 0.3402
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0263 0.0279
Leishmania major proteasome beta 3 subunit, putative 0.003 0.035 0.0407
Loa Loa (eye worm) proteasome subunit beta type 3 0.003 0.035 0.0371
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.1555 0.1555
Leishmania major phospholipase c-like protein 0.0028 0.0299 0.0274
Trypanosoma cruzi calmodulin, putative 0.0028 0.0299 0.0133
Brugia malayi proteasome subunit beta type 1 0.0078 0.1291 0.1368
Echinococcus multilocularis tumor protein p63 0.0326 0.6232 0.6232
Brugia malayi cathepsin L-like precursor 0.0065 0.1037 0.1098
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0074 0.121 0.1285
Trichomonas vaginalis calmodulin, putative 0.0028 0.0307 0.0449
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Schistosoma mansoni reticulocalbin 0.0028 0.0307 0.0196
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0113 0.012
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.003 0.035 0.024
Plasmodium vivax proteasome subunit alpha type-5, putative 0.003 0.035 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.1555 0.3342
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0945 0.0842
Schistosoma mansoni Mername-AA248 (C02 family) 0.0184 0.3402 0.3329
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0078 0.1291 0.2856
Loa Loa (eye worm) calpain family protein 1 0.0487 0.9438 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.011 0.194 0.2207
Schistosoma mansoni calmodulin 0.0028 0.0299 0.0188
Onchocerca volvulus 0.0028 0.0307 0.0055
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Giardia lamblia 20S proteasome alpha subunit 5 0.003 0.035 0.0195
Loa Loa (eye worm) hypothetical protein 0.0026 0.0263 0.0279
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Entamoeba histolytica calcium binding family protein 0.0028 0.0299 0.0473
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0028 0.0299 0.043
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0113 0.012
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Brugia malayi hypothetical protein 0.0438 0.8448 0.8951
Brugia malayi 20S proteasome alpha5 subunit 0.003 0.035 0.0371
Onchocerca volvulus 0.0146 0.2646 0.4304
Trypanosoma brucei Component of motile flagella 41 0.0028 0.0299 0.0274
Echinococcus multilocularis neuronal calcium sensor 0.0028 0.0299 0.0299
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0028 0.0299 0.0133
Brugia malayi calpain 5 0.0129 0.2302 0.2439
Echinococcus multilocularis Proteasome subunit alpha type 7 0.003 0.035 0.035
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Loa Loa (eye worm) hypothetical protein 0.0304 0.5782 0.6126
Echinococcus multilocularis cysteine protease 0.0091 0.1555 0.1555
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0216 0.4038 0.4858
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.003 0.035 0.0371
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Trypanosoma brucei mitochondrial calcium uptake 1 0.0028 0.0299 0.0274
Trypanosoma brucei caltractin, putative 0.0028 0.0299 0.0274
Echinococcus granulosus cathepsin L cysteine proteinase 0.0091 0.1555 0.1555
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.003 0.035 0.0407
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.003 0.035 0.0603
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.2698 0.2617
Brugia malayi EF hand family protein 0.0028 0.0299 0.0316
Plasmodium vivax SET domain protein, putative 0.003 0.0335 0.019
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0074 0.121 0.2645
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Echinococcus multilocularis Proteasome subunit alpha type 7 0.003 0.035 0.035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.8107 0.8092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Loa Loa (eye worm) calmodulin-like protein 0.0028 0.0299 0.0316
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0027 0.0277 0.0416
Trypanosoma cruzi calmodulin, putative 0.0028 0.0299 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0945 0.0945
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.003 0.035 0.0198
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Loa Loa (eye worm) hypothetical protein 0.0487 0.9438 1
Brugia malayi Proteasome subunit alpha type 1 0.003 0.035 0.0371
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.1555 0.1459
Giardia lamblia 20S proteasome alpha subunit 3 0.003 0.035 0.0195
Brugia malayi calpain family protein 1 0.0487 0.9438 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus granulosus Tolloid protein 1 0.004 0.0536 0.0536
Brugia malayi Cytochrome P450 family protein 0.0023 0.0193 0.0205
Loa Loa (eye worm) calpain family protein 1 0.0359 0.6881 0.7291
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Plasmodium falciparum calpain 0.0055 0.0844 0.1509
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.1037 0.2353
Trypanosoma cruzi centrin, putative 0.0028 0.0299 0.0133
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.004 0.0536 0.0428
Loa Loa (eye worm) bone morphogenetic protein 1b 0.004 0.0536 0.0567
Onchocerca volvulus 0.0091 0.1555 0.2322
Toxoplasma gondii heat shock protein hslv, putative 0.003 0.035 0.0866
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0945 0.1956
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Echinococcus multilocularis survival motor neuron protein 1 0.0438 0.8448 0.8448
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.003 0.035 0.0198
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0285 0.5418 0.574
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.003 0.035 0.0198
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0216 0.4038 1
Plasmodium falciparum centrin-1 0.0028 0.0299 0.0059
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.003 0.035 0.0198
Leishmania major centrin, putative 0.0028 0.0299 0.0274
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.003 0.035 0.0603
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0335 0.0335
Echinococcus multilocularis Tolloid protein 1 0.004 0.0536 0.0536
Echinococcus granulosus EF hand domain containing family member A2 0.0028 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Schistosoma mansoni rab 0.0028 0.0299 0.0188
Trichomonas vaginalis calcium binding proteins, putative 0.0028 0.0299 0.043
Plasmodium falciparum proteasome subunit beta type-4 0.003 0.035 0.0195
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Echinococcus multilocularis calpain A 0.0516 1 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.003 0.035 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.1037 0.2141
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0074 0.121 0.2543
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0113 0.0113
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Trypanosoma brucei centrin-3 0.0028 0.0299 0.0274
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0113 0.012
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.1037 0.2141
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0945 0.0945
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0335 0.0335
Brugia malayi PXA domain containing protein 0.0019 0.0113 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Loa Loa (eye worm) proteasome subunit beta type 1 0.0078 0.1291 0.1368
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0028 0.0299 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0113 0.0113
Leishmania major centrin, putative,caltractin, putative 0.0028 0.0299 0.0274
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0113 0.0113
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0113 0.012
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0807 0.0855
Trypanosoma cruzi cysteine protease, putative 0.0053 0.0795 0.076
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.003 0.035 0.0603
Plasmodium vivax unspecified product 0.0027 0.0277 0.0035
Onchocerca volvulus 0.0091 0.1555 0.2322
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Echinococcus granulosus cathepsin L 0.0027 0.0277 0.0277
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.003 0.035 0.024
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0074 0.121 0.2795
Entamoeba histolytica calmodulin, putative 0.0028 0.0299 0.0473
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Leishmania major kinesin, putative 0.0129 0.2302 0.5485
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Leishmania major hypothetical protein, conserved 0.0028 0.0299 0.0274
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Brugia malayi proteasome subunit alpha type 1 0.003 0.035 0.0371
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Leishmania major cysteine peptidase A (CPA) 0.0091 0.1555 0.3541
Loa Loa (eye worm) hypothetical protein 0.0065 0.1037 0.1098
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.003 0.035 0.0198
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0091 0.1555 0.1647
Echinococcus granulosus calpain A 0.0184 0.3402 0.3402
Loa Loa (eye worm) fibroinase 0.0091 0.1555 0.1647
Plasmodium vivax proteasome subunit beta type-1, putative 0.0078 0.1291 0.2723
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.003 0.035 0.0603
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.0823
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2458 0.2862
Echinococcus multilocularis proteasome subunit alpha type 2 0.003 0.035 0.035
Brugia malayi cathepsin Z-like cysteine proteinase 0.0027 0.0277 0.0293
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0421 0.8107 1
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Leishmania major protein kinase, putative 0.0028 0.0299 0.0274
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.1555 0.1555
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0193 0.0205
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0113 0.0113
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.003 0.035 0.0195
Plasmodium vivax proteasome subunit beta type-5, putative 0.0216 0.4038 1
Trypanosoma brucei centrin, putative 0.0028 0.0299 0.0274
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0113 0.0113
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.003 0.035 0.024
Toxoplasma gondii EFHC1, putative 0.0028 0.0299 0.0739
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0945 0.1956
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0113 0.0113
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.003 0.035 0.024
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.003 0.035 0.0195
Loa Loa (eye worm) hypothetical protein 0.0026 0.0263 0.0279
Loa Loa (eye worm) hypothetical protein 0.003 0.0335 0.0355
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Echinococcus granulosus cathepsin L 0.0053 0.0795 0.0795
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.003 0.035 0.0371
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0027 0.0277 0.0416
Trichomonas vaginalis calmodulin-2, putative 0.0028 0.0299 0.043
Schistosoma mansoni cathepsin S (C01 family) 0.0027 0.0277 0.0165
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0277 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trypanosoma brucei proteasome beta 3 subunit, putative 0.003 0.035 0.0407
Onchocerca volvulus Cathepsin L homolog 0.0091 0.1555 0.2322
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0113 0.0113
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.003 0.035 0.0603
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Giardia lamblia Proteasome subunit beta type 7 precursor 0.003 0.035 0.0195
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1555 0.3673
Schistosoma mansoni gamma-secretase subunit aph-1 0.0143 0.2591 0.2509
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0055 0.0844 0.1693
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0113 0.0113
Trypanosoma cruzi Aph-1 protein, putative 0.0056 0.0854 0.0835
Trypanosoma brucei proteasome beta 6 subunit 0.0078 0.1291 0.2856
Trichomonas vaginalis calpain, putative 0.0055 0.0844 0.1695
Toxoplasma gondii peptidase, T1 family protein 0.003 0.035 0.0866
Echinococcus multilocularis programmed cell death protein 0.0028 0.0299 0.0299
Schistosoma mansoni calpain (C02 family) 0.0184 0.3402 0.3329
Brugia malayi hypothetical protein 0.0019 0.0113 0.012
Echinococcus multilocularis EF hand domain containing family member A2 0.0028 0.0307 0.0307
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Echinococcus multilocularis Proteasome, subunit alpha beta 0.003 0.035 0.035
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0074 0.121 0.2997
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0795 0.069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0028 0.0299 0.0133
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0113 0.0113
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0074 0.121 0.1111
Entamoeba histolytica calpain family cysteine protease, putative 0.0055 0.0844 0.1863
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Brugia malayi proteasome subunit alpha type 3 0.003 0.035 0.0371
Echinococcus granulosus 20S proteasome subunit alpha 6 0.003 0.035 0.035
Schistosoma mansoni calmodulin related calcium binding protein 0.0028 0.0299 0.0188
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0078 0.1291 0.3198
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0945 0.0842
Loa Loa (eye worm) hypothetical protein 0.0065 0.1037 0.1098
Toxoplasma gondii cathepsin CPC2 0.0027 0.0277 0.0685
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.003 0.035 0.0407
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0515 0.9992 0.9992
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0078 0.1291 0.3002
Brugia malayi PXA domain containing protein 0.0019 0.0113 0.012
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0216 0.4038 0.3973
Schistosoma mansoni cathepsin B (C01 family) 0.0027 0.0277 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0299 0.043
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0028 0.0299 0.0473
Trypanosoma brucei cysteine peptidase, putative 0.0055 0.0844 0.1693
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0421 0.8107 0.8092
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0216 0.4038 1
Trypanosoma brucei centrin, putative 0.0028 0.0299 0.0274
Brugia malayi cathepsin L-like cysteine proteinase 0.0027 0.0277 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus multilocularis neurocalcin 0.0028 0.0299 0.0299
Echinococcus granulosus proteasome subunit alpha type 6 0.003 0.035 0.035
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1555 0.3673
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.8107 0.8092
Echinococcus granulosus proteasome subunit beta type 7 0.003 0.035 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0277 0.0379
Entamoeba histolytica hypothetical protein 0.0027 0.0277 0.0416
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0216 0.4038 0.9099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0313 0.0313
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0216 0.4038 1
Loa Loa (eye worm) ctsf protein 0.0091 0.1555 0.1647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0795 0.0842
Trypanosoma cruzi centrin-3 0.0028 0.0299 0.0133
Echinococcus granulosus proteasome subunit beta t family 0.003 0.035 0.035
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.003 0.035 0.0195
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0193 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0795 0.158
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0795 0.158
Echinococcus granulosus proteasome subunit alpha type 2 0.003 0.035 0.035
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0307 0.0493
Trypanosoma brucei calpain, putative 0.0055 0.0844 0.1693
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0078 0.1291 0.2698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Brugia malayi calpain D 0.0055 0.0844 0.0895
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0113 0.012
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.003 0.035 0.0198
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.003 0.035 0.0603
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis centrin, putative 0.0028 0.0299 0.043
Brugia malayi Proteasome A-type and B-type family protein 0.003 0.035 0.0371
Trypanosoma brucei antigen, putative 0.0184 0.3402 0.8344
Onchocerca volvulus 0.003 0.0335 0.0106
Toxoplasma gondii EF hand domain-containing protein 0.0028 0.0299 0.0739
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.1693
Onchocerca volvulus Cathepsin L homolog 0.0091 0.1555 0.2322
Entamoeba histolytica calpain large subunit domain III containing protein 0.0129 0.2302 0.5577
Echinococcus granulosus proteasome subunit beta type 6 0.003 0.035 0.035
Giardia lamblia 20S proteasome alpha subunit 6 0.003 0.035 0.0195
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.003 0.035 0.024
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.2458 0.2862
Giardia lamblia 20S proteasome alpha subunit 7 0.003 0.035 0.0195
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.1555 0.1555
Trypanosoma brucei calpain, putative 0.0055 0.0844 0.1693
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0027 0.0277 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus multilocularis EF hand domain containing family member A2 0.0028 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0216 0.4038 0.4858
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0113 0.0113
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0113 0.0113
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.003 0.035 0.0195
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.003 0.035 0.0603
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.003 0.035 0.035
Schistosoma mansoni cathepsin s 0.0026 0.0263 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Leishmania major calpain family cysteine protease-like protein 0.0055 0.0844 0.1693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Onchocerca volvulus 0.0028 0.0299 0.004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0515 0.9992 1
Leishmania major calmodulin, putative 0.0028 0.0299 0.0274
Echinococcus granulosus cysteine protease 0.0053 0.0795 0.0795
Brugia malayi Proteasome A-type and B-type family protein 0.003 0.035 0.0371
Loa Loa (eye worm) hypothetical protein 0.0038 0.0503 0.0533
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0795 0.076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Echinococcus multilocularis proteasome subunit beta type 7 0.003 0.035 0.035
Brugia malayi follicle stimulating hormone receptor 0.0285 0.5418 0.574
Echinococcus multilocularis calpain 7 (C02 family) 0.0184 0.3402 0.3402
Loa Loa (eye worm) hypothetical protein 0.0048 0.0695 0.0736
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Schistosoma mansoni reticulocalbin 0.0028 0.0299 0.0188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0335 0.0335
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Loa Loa (eye worm) programmed cell death protein 6 0.0028 0.0307 0.0325
Giardia lamblia Proteasome subunit beta type 1 0.0078 0.1291 0.2698
Toxoplasma gondii calcium-dependent protein kinase 0.0028 0.0307 0.076
Plasmodium vivax proteasome subunit beta type-4, putative 0.003 0.035 0.0229
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0027 0.0277 0.0035
Schistosoma mansoni hypothetical protein 0.0028 0.0299 0.0188
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0113 0.0113
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0028 0.0299 0.0299
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0113 0.0113
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.0823
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.8107 0.8092
Trypanosoma brucei kinesin, putative 0.0129 0.2302 0.5485
Plasmodium falciparum cysteine proteinase falcipain 3 0.0091 0.1555 0.3398
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0027 0.0277 0.0035
Loa Loa (eye worm) cysteine protease 0.0091 0.1555 0.1647
Plasmodium vivax proteasome subunit alpha type-4, putative 0.003 0.035 0.0229
Giardia lamblia Cathepsin B precursor 0.0149 0.2698 0.6438
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Brugia malayi calpain 5 0.0055 0.0844 0.0895
Echinococcus granulosus cathepsin b 0.0421 0.8107 0.8107
Echinococcus multilocularis cathepsin L 0.0053 0.0795 0.0795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Leishmania major calmodulin-like protein 0.0028 0.0299 0.0274
Entamoeba histolytica calcium-binding protein, putative 0.0028 0.0299 0.0473
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Brugia malayi cathepsin F-like cysteine proteinase 0.0026 0.0263 0.0279
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0028 0.0299 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis centrin, putative 0.0028 0.0299 0.043
Echinococcus multilocularis calpain 0.0184 0.3402 0.3402
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0113 0.0113
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.003 0.035 0.0603
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0074 0.121 0.2543
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0193 0.0205
Echinococcus multilocularis proteasome subunit beta type 6 0.003 0.035 0.035
Brugia malayi Cathepsin L-like precursor 0.0065 0.1037 0.1098
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.003 0.035 0.5
Loa Loa (eye worm) calpain 5 0.0129 0.2302 0.2439
Plasmodium vivax proteasome subunit beta type-3, putative 0.003 0.035 0.0229
Brugia malayi Papain family cysteine protease containing protein 0.0091 0.1555 0.1647
Brugia malayi cathepsin Z-like cysteine proteinase 0.0027 0.0277 0.0293
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Onchocerca volvulus 0.0048 0.0695 0.0759
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.003 0.035 0.0603
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0027 0.0277 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.003 0.035 0.0603
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0078 0.1291 0.1387
Entamoeba histolytica cysteine protease, putative 0.0091 0.1555 0.3673
Echinococcus multilocularis gamma secretase subunit aph 1 0.0143 0.2591 0.2591
Plasmodium vivax serine-repeat antigen (SERA) 0.0027 0.0277 0.0035
Echinococcus multilocularis calcium uptake protein 1 0.0028 0.0307 0.0307
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0027 0.0277 0.0035
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.003 0.035 0.0195
Toxoplasma gondii hypothetical protein 0.0055 0.0844 0.2091
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0795 0.069
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Echinococcus granulosus programmed cell death protein 0.0028 0.0299 0.0299
Schistosoma mansoni centrin 0.0028 0.0299 0.0188
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0216 0.4038 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0065 0.1037 0.1098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0055 0.0844 0.0823
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trypanosoma cruzi major cysteine proteinase, putative 0.0027 0.0277 0.0105
Trypanosoma brucei ATP-dependent protease subunit HslV 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0027 0.0277 0.0379
Trypanosoma brucei Calpain-like protein 1.2 0.0055 0.0844 0.1693
Echinococcus granulosus neurocalcin 0.0028 0.0299 0.0299
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0113 0.0113
Brugia malayi Cytochrome P450 family protein 0.0053 0.0807 0.0855
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.003 0.035 0.0198
Entamoeba histolytica grainin 2 0.0028 0.0299 0.0473
Trypanosoma brucei Aph-1 protein, putative 0.0056 0.0854 0.1719
Leishmania major proteasome alpha 2 subunit, putative 0.003 0.035 0.0407
Echinococcus granulosus subfamily T1A non peptidase ue 0.003 0.035 0.035
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0795 0.0842
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus multilocularis centrin 2 0.0028 0.0299 0.0299
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.003 0.035 0.0198
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.003 0.035 0.0603
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0074 0.121 0.121
Echinococcus granulosus calpain 0.0184 0.3402 0.3402
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0074 0.121 0.1111
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Leishmania major cathepsin L-like protease 0.0136 0.2458 0.5891
Trypanosoma cruzi I/6 autoantigen, putative 0.0028 0.0299 0.0133
Giardia lamblia Cathepsin B precursor 0.0149 0.2698 0.6438
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.003 0.035 0.035
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.003 0.035 0.0198
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0795 0.069
Mycobacterium ulcerans proteasome PrcA 0.003 0.035 0.0407
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Toxoplasma gondii proteasome beta subunit 0.003 0.035 0.0866
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0027 0.0277 0.0035
Schistosoma mansoni calmodulin 0.0028 0.0299 0.0188
Giardia lamblia 20S proteasome alpha subunit 2 0.003 0.035 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0335 0.0225
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0149 0.2698 0.6515
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.003 0.035 0.0198
Brugia malayi cathepsin B-like cysteine proteinase 0.0421 0.8107 0.859
Trichomonas vaginalis calcineurin B subunit, putative 0.0028 0.0307 0.0449
Echinococcus multilocularis cysteine protease 0.0091 0.1555 0.1555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Giardia lamblia Cathepsin B precursor 0.0149 0.2698 0.6438
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0091 0.1555 0.1647
Brugia malayi Pre-SET motif family protein 0.003 0.0335 0.0355
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.003 0.035 0.024
Onchocerca volvulus 0.0091 0.1555 0.2322
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Toxoplasma gondii troponin c, isotype gamma, putative 0.0028 0.0299 0.0739
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Trypanosoma brucei I/6 autoantigen 0.0028 0.0299 0.0274
Echinococcus granulosus survival motor neuron protein 1 0.0438 0.8448 0.8448
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0091 0.1555 0.3398
Echinococcus multilocularis calmodulin 0.0028 0.0299 0.0299
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.003 0.035 0.035
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0113 0.012
Schistosoma mansoni survival motor neuron protein 0.0089 0.152 0.1424
Leishmania major calmodulin-like protein 0.0028 0.0299 0.0274
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Leishmania major proteasome beta 2 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0277 0.0379
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0515 0.9992 0.9992
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0945 0.1614
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.003 0.035 0.0603
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0113 0.012
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.003 0.035 0.0371
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0027 0.0277 0.0035
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0216 0.4038 0.4279
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0028 0.0299 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0028 0.0299 0.0274
Schistosoma mansoni centrin-related 0.0028 0.0299 0.0188
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.003 0.035 0.0198
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.003 0.035 0.0407
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0945 0.1956
Brugia malayi calcium-binding protein 0.0028 0.0299 0.0316
Echinococcus granulosus proteasome prosome macropain 0.0216 0.4038 0.4038
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0078 0.1291 0.1193
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.003 0.035 0.0603
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Trypanosoma brucei protein I/6 0.0028 0.0299 0.0274
Plasmodium falciparum proteasome subunit beta type-3, putative 0.003 0.035 0.0195
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Brugia malayi calpain family protein 1 0.0487 0.9438 1
Giardia lamblia Proteasome subunit beta type 4 precursor 0.003 0.035 0.0195
Trypanosoma brucei cysteine peptidase C (CPC) 0.0149 0.2698 0.6515
Brugia malayi programmed cell death protein 6 0.0028 0.0299 0.0316
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.003 0.035 0.035
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Trypanosoma brucei hypothetical protein 0.0055 0.0844 0.1693
Trypanosoma brucei proteasome beta 2 subunit, putative 0.003 0.035 0.0407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0335 0.0225
Leishmania major proteasome beta 5 subunit, putative 0.0216 0.4038 1
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0055 0.0844 0.1693
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Brugia malayi Cathepsin L-like precursor 0.0026 0.0263 0.0279
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Onchocerca volvulus 0.0236 0.4432 0.7548
Echinococcus granulosus cathepsin l1 0.0065 0.1037 0.1037
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0149 0.2698 0.3165
Echinococcus granulosus cathepsin L cysteine protease 0.0053 0.0795 0.0795
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.003 0.035 0.0866
Toxoplasma gondii cathepsin CPC1 0.0027 0.0277 0.0685
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.003 0.035 0.024
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0078 0.1291 0.2731
Toxoplasma gondii proteasome subunit alpha type, putative 0.003 0.035 0.0866
Trypanosoma brucei Calpain-like protein CALP1.3 0.0055 0.0844 0.1693
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.003 0.035 0.024
Echinococcus multilocularis cathepsin b 0.0421 0.8107 0.8107
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.003 0.035 0.0195
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Onchocerca volvulus 0.0091 0.1555 0.2322
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0113 0.0113
Echinococcus granulosus cathepsin b 0.0421 0.8107 0.8107
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0113 0.012
Leishmania major programmed cell death 6 protein-like protein 0.0028 0.0299 0.0274
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Schistosoma mansoni ef hand domain family member A2 0.0028 0.0299 0.0188
Onchocerca volvulus 0.0089 0.152 0.2259
Trichomonas vaginalis calcineurin B subunit, putative 0.0028 0.0299 0.043
Echinococcus multilocularis subfamily T1A non peptidase ue 0.003 0.035 0.035
Leishmania major proteasome alpha 7 subunit, putative 0.003 0.035 0.0407
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.003 0.035 0.0198
Loa Loa (eye worm) hypothetical protein 0.0065 0.1037 0.1098
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.003 0.035 0.0198
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Echinococcus granulosus calbindin 32 0.0028 0.0307 0.0307
Echinococcus multilocularis calmodulin 0.0028 0.0299 0.0299
Toxoplasma gondii proteasome subunit beta type, putative 0.0216 0.4038 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Schistosoma mansoni hypothetical protein 0.0055 0.0844 0.074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Leishmania major hypothetical protein, unknown function 0.0055 0.0844 0.1693
Mycobacterium ulcerans proteasome PrcB 0.0216 0.4038 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0027 0.0277 0.0293
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0028 0.0307 0.0196
Loa Loa (eye worm) proteasome subunit beta type 2 0.0074 0.121 0.1282
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0027 0.0277 0.0293
Trypanosoma cruzi conserved protein 0.0055 0.0844 0.0823
Trypanosoma cruzi calmodulin, putative 0.0028 0.0299 0.0133
Loa Loa (eye worm) proteasome subunit alpha type 2 0.003 0.035 0.0371
Loa Loa (eye worm) hypothetical protein 0.0055 0.0844 0.0895
Leishmania major calmodulin, putative 0.0028 0.0299 0.0274
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.003 0.035 0.0371
Plasmodium falciparum proteasome subunit beta type-7, putative 0.003 0.035 0.0195
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0027 0.0277 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0307 0.0115
Plasmodium vivax proteasome subunit alpha type-6, putative 0.003 0.035 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0091 0.1555 0.3398
Plasmodium vivax proteasome subunit alpha type-3, putative 0.003 0.035 0.0229
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.003 0.035 0.024
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.1037 0.0935
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus multilocularis calpain 5 0.0184 0.3402 0.3402
Echinococcus granulosus calumenin 0.0028 0.0307 0.0307
Onchocerca volvulus 0.0065 0.1037 0.1381
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.003 0.035 0.0371
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0027 0.0277 0.0035
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Leishmania major proteasome alpha 1 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0028 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0026 0.0263 0.0279
Echinococcus multilocularis proteasome subunit alpha type 6 0.003 0.035 0.035
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0027 0.0277 0.0035
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.003 0.035 0.0407
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0028 0.0299 0.043
Plasmodium vivax vivapain-1 0.0053 0.0795 0.1408
Brugia malayi proteasome subunit beta type 2 0.0074 0.121 0.1282
Loa Loa (eye worm) EF hand family protein 0.0028 0.0299 0.0316
Trypanosoma brucei calmodulin, putative 0.0028 0.0307 0.0295
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0263 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Plasmodium vivax proteasome subunit beta type-7, putative 0.003 0.035 0.0229
Entamoeba histolytica grainin, putative 0.0028 0.0307 0.0493
Giardia lamblia Hypothetical protein 0.0028 0.0307 0.008
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.003 0.035 0.024
Brugia malayi Proteasome A-type and B-type family protein 0.003 0.035 0.0371
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0078 0.1291 0.1291
Brugia malayi EF hand family protein 0.0028 0.0307 0.0325
Schistosoma mansoni hypothetical protein 0.0089 0.152 0.1424
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0089 0.152 0.1611
Loa Loa (eye worm) proteasome subunit alpha type 3 0.003 0.035 0.0371
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0113 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Schistosoma mansoni cathepsin C 0.0027 0.0277 0.0165
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.003 0.035 0.024
Echinococcus granulosus tumor protein p63 0.0326 0.6232 0.6232
Leishmania major calpain protease-like protein 0.0055 0.0844 0.1693
Trypanosoma brucei calmodulin, putative 0.0028 0.0299 0.0274
Brugia malayi proteasome subunit alpha type 6 0.003 0.035 0.0371
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Loa Loa (eye worm) hypothetical protein 0.0432 0.8339 0.8835
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.003 0.035 0.0198
Trichomonas vaginalis calpain, putative 0.0055 0.0844 0.1695
Onchocerca volvulus Cathepsin F homolog 0.0091 0.1555 0.2322
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0026 0.0263 0.0279
Leishmania major cathepsin L-like protease 0.0136 0.2458 0.5891
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0795 0.076
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.003 0.035 0.0198
Schistosoma mansoni calpain-7 (C02 family) 0.0184 0.3402 0.3329
Brugia malayi hypothetical protein 0.0019 0.0113 0.012
Trypanosoma cruzi centrin, putative 0.0028 0.0299 0.0133
Echinococcus granulosus EF HAND 1 calcium binding site 0.0028 0.0299 0.0299
Leishmania major calcineurin B subunit, putative 0.0028 0.0299 0.0274
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 39.81071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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