Detailed information for compound 1410205

Basic information

Technical information
  • TDR Targets ID: 1410205
  • Name: 3-(3-chlorophenyl)diazenyl-5,7-dimethylpyrazo lo[1,5-a]pyrimidin-2-amine
  • MW: 300.746 | Formula: C14H13ClN6
  • H donors: 1 H acceptors: 2 LogP: 3.18 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)N=Nc1c(N)nn2c1nc(C)cc2C
  • InChi: 1S/C14H13ClN6/c1-8-6-9(2)21-14(17-8)12(13(16)20-21)19-18-11-5-3-4-10(15)7-11/h3-7H,1-2H3,(H2,16,20)
  • InChiKey: AYTMKTRTLCIZGP-UHFFFAOYSA-N  


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Synonyms

  • 3-(3-chlorophenyl)azo-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-2-amine
  • 3-(3-chlorophenyl)azo-5,7-dimethyl-2-pyrazolo[1,5-a]pyrimidinamine
  • [3-(3-chlorophenyl)azo-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-2-yl]amine
  • 3-(3-chlorophenyl)diazenyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-2-amine
  • ZINC04350473
  • 3-[(3-chlorophenyl)diazenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-amine
  • MLS000701175
  • SMR000226411
  • AH-153/33258012

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus gamma secretase subunit aph 1 0.0243 0.1169 0.1151
Trypanosoma cruzi cysteine proteinase, putative 0.0456 0.2283 0.2266
Trypanosoma brucei hypothetical protein 0.0176 0.0823 0.0961
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0025 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0052 0.0121
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0023 0.0022 0.0001
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0281 0.137 0.1352
Onchocerca volvulus 0.0492 0.2473 0.3143
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0281 0.137 0.1351
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0281 0.137 0.1724
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0079 0.0079
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.0228 0.0207
Trypanosoma brucei prolyl oligopeptidase, putative 0.0621 0.3145 0.3959
Schistosoma mansoni cathepsin F (C01 family) 0.0834 0.426 0.4248
Echinococcus multilocularis EF hand domain containing family member A2 0.0095 0.0398 0.0378
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1516 0.7824 1
Onchocerca volvulus 0.0968 0.4958 0.6327
Plasmodium falciparum serine repeat antigen 9 0.0198 0.0935 0.2169
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0116 0.0096
Echinococcus granulosus glycogen phosphorylase 0.0107 0.046 0.0441
Plasmodium vivax calpain, putative 0.0586 0.2964 0.6949
Brugia malayi hypothetical protein 0.0034 0.0082 0.0062
Leishmania major hypothetical protein, conserved 0.0095 0.0398 0.0478
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0014 0.0009
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Trypanosoma brucei calmodulin, putative 0.0093 0.0389 0.0401
Schistosoma mansoni glycogen phosphorylase 0.0046 0.0144 0.0123
Loa Loa (eye worm) proteasome subunit beta type 1 0.0066 0.025 0.025
Echinococcus multilocularis neuronal calcium sensor 0.0093 0.0389 0.037
Echinococcus multilocularis Transglutaminase 0.0546 0.2755 0.2741
Brugia malayi Cell death protein 3 precursor 0.0062 0.0228 0.0207
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0396 0.0375
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0066 0.025 0.0537
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Schistosoma mansoni calpain-2 (C02 family) 0.0176 0.0823 0.0804
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0116 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.056 0.1744
Trypanosoma brucei Calpain-like protein CALP1.3 0.0176 0.0823 0.0961
Mycobacterium leprae Probable lipase LipE 0.0036 0.0089 0.012
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0089 0.0118
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.125 0.1231
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2964 0.3726
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0041 0.0117 0.0097
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Brugia malayi proteasome subunit beta type 1 0.0066 0.025 0.0229
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0093 0.0389 0.037
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1554 0.802 0.8016
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0034
Loa Loa (eye worm) trypsin family protein 0.0034 0.0082 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0385 0.0366
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0041 0.0117 0.0097
Loa Loa (eye worm) hypothetical protein 0.0198 0.0935 0.0935
Echinococcus multilocularis caspase 2 0.0062 0.0228 0.0207
Giardia lamblia Cathepsin B precursor 0.0734 0.3739 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.056 0.0541
Onchocerca volvulus 0.0093 0.0389 0.0473
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.0089
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0368 0.0816
Echinococcus granulosus histone deacetylase 1 0.0089 0.0368 0.0348
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1331 0.6855 1
Leishmania major cathepsin L-like protease 0.0834 0.426 0.543
Loa Loa (eye worm) cysteine protease 0.0834 0.426 0.426
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0116 0.0096
Echinococcus granulosus geminin 0.0169 0.0785 0.0766
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0116 0.0096
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0389 0.037
Giardia lamblia Hypothetical protein 0.0095 0.0398 0.1012
Trypanosoma brucei mitochondrial calcium uptake 1 0.0093 0.0389 0.0401
Plasmodium falciparum serine repeat antigen 5 0.0198 0.0935 0.2169
Giardia lamblia Cathepsin L precursor 0.0198 0.0935 0.2457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Giardia lamblia Cathepsin B precursor 0.0198 0.0935 0.2457
Onchocerca volvulus Cathepsin L homolog 0.0198 0.0935 0.1172
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0198 0.0935 0.2169
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0034 0.0082 0.0062
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Schistosoma mansoni calpain-7 (C02 family) 0.0589 0.298 0.2965
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0198 0.0935 0.2169
Schistosoma mansoni cathepsin F (C01 family) 0.0576 0.2912 0.2897
Trypanosoma cruzi prolyl endopeptidase 0.1516 0.7824 0.7819
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0021 0.0021
Brugia malayi Cytochrome P450 family protein 0.0056 0.0194 0.0174
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0165 0.0145
Brugia malayi hypothetical protein 0.0095 0.0401 0.0381
Trypanosoma brucei hypothetical protein, conserved 0.0093 0.0389 0.0401
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0089 0.0158
Trypanosoma brucei histone deacetylase 1 0.0089 0.0368 0.0373
Echinococcus granulosus calpain 7 C02 family 0.0586 0.2964 0.295
Loa Loa (eye worm) hypothetical protein 0.0576 0.2912 0.2912
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1647 0.8507 0.8504
Giardia lamblia Cathepsin L precursor 0.0198 0.0935 0.2457
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0066 0.025 0.0229
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.2949
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.2004 0.1987
Trichomonas vaginalis peptide N-glycanase, putative 0.0546 0.2755 0.645
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0116 0.0096
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Loa Loa (eye worm) hypothetical protein 0.0968 0.4958 0.4958
Loa Loa (eye worm) histone deacetylase 1 0.0089 0.0368 0.0368
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0823 0.189
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0116 0.0096
Echinococcus multilocularis calpain family protein 1, d 0.1144 0.5878 0.587
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0389 0.037
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0198 0.0935 0.2155
Trichomonas vaginalis calcineurin B subunit, putative 0.0093 0.0389 0.0867
Echinococcus multilocularis hypothetical protein 0.0586 0.2964 0.295
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0052
Plasmodium falciparum serine repeat antigen 7 0.0198 0.0935 0.2169
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.0935 0.2155
Brugia malayi Serine carboxypeptidase S28 family protein 0.0023 0.0022 0.0001
Onchocerca volvulus 0.0834 0.426 0.5432
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0871 0.2003
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0198 0.0935 0.2457
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0214 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2912 0.6819
Echinococcus multilocularis cathepsin L cysteine protease 0.0834 0.426 0.4248
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0116 0.0096
Echinococcus multilocularis histone deacetylase 7 0.01 0.0425 0.0406
Schistosoma mansoni hypothetical protein 0.005 0.0165 0.0145
Onchocerca volvulus 0.0198 0.0935 0.1172
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0961
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1095 0.1587
Brugia malayi beta-lactamase family protein 0.0036 0.0089 0.0069
Schistosoma mansoni hypothetical protein 0.0169 0.0785 0.0766
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0426 0.213 0.2113
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0185 0.0871 0.1023
Loa Loa (eye worm) cathepsin B 0.0734 0.3739 0.3739
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0089 0.0069
Loa Loa (eye worm) hypothetical protein 0.0159 0.0735 0.0735
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0368 0.0816
Echinococcus granulosus calpain 0.0586 0.2964 0.295
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1647 0.8507 0.8504
Schistosoma mansoni histone deacetylase 0.0089 0.0368 0.0348
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0093 0.0389 0.037
Plasmodium vivax serine-repeat antigen (SERA) 0.0198 0.0935 0.2169
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Schistosoma mansoni gamma-secretase subunit aph-1 0.0243 0.1169 0.1151
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0079 0.0207
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0079 0.0057
Leishmania major histone deacetylase, putative 0.0089 0.0368 0.044
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Brugia malayi calpain 5 0.0176 0.0823 0.0804
Entamoeba histolytica prolyl oligopeptidase family protein 0.0185 0.0871 0.2003
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0961
Schistosoma mansoni reticulocalbin 0.0095 0.0398 0.0378
Loa Loa (eye worm) prolyl oligopeptidase 0.0528 0.2659 0.2659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0095 0.0398 0.0377
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1933 1 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0281 0.137 0.1667
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0023 0.0022 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0194 0.022
Echinococcus granulosus Transglutaminase 0.0546 0.2755 0.2741
Trypanosoma cruzi centrin, putative 0.0093 0.0389 0.0368
Onchocerca volvulus Deterin homolog 0.0136 0.0613 0.0759
Toxoplasma gondii centrin 0.0093 0.0389 0.0471
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0834 0.426 0.4248
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0823 0.0803
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0871 0.0851
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Loa Loa (eye worm) hypothetical protein 0.0185 0.0871 0.0871
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.2949
Loa Loa (eye worm) hypothetical protein 0.0095 0.0401 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Loa Loa (eye worm) hypothetical protein 0.0834 0.426 0.426
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0086 0.0349 0.0772
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0025 0.0005
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Mycobacterium ulcerans hypothetical protein 0.0034 0.0082 0.0218
Schistosoma mansoni hypothetical protein 0.0062 0.0228 0.0207
Trypanosoma cruzi cysteine peptidase, putative 0.0456 0.2283 0.2266
Brugia malayi Protein kinase domain containing protein 0.0024 0.0025 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0935 0.2155
Giardia lamblia Cathepsin L precursor 0.0198 0.0935 0.2457
Onchocerca volvulus Histone deacetylase 10 homolog 0.0043 0.0127 0.0136
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0041 0.0117 0.0243
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0198 0.0935 0.2457
Loa Loa (eye worm) calmodulin-like protein 0.0093 0.0389 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0961
Echinococcus multilocularis calbindin 32 0.0095 0.0398 0.0378
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0198 0.0935 0.2155
Trypanosoma cruzi cysteine protease, putative 0.0456 0.2283 0.2266
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0116 0.0096
Brugia malayi prolyl oligopeptidase family protein 0.0185 0.0871 0.0852
Brugia malayi Cathepsin L-like precursor 0.0834 0.426 0.4248
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0127 0.0105
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.0349 0.0328
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.056 0.1744
Brugia malayi Cathepsin L-like precursor 0.0576 0.2912 0.2897
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0052 0.0071
Brugia malayi hypothetical protein 0.0246 0.119 0.1172
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0621 0.3145 0.3959
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0389 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Echinococcus multilocularis histone deacetylase 3 0.0089 0.0368 0.0348
Brugia malayi MH2 domain containing protein 0.0127 0.0565 0.0546
Brugia malayi Trypsin-like protease protein 5 0.0034 0.0082 0.0062
Echinococcus granulosus neurocalcin 0.0093 0.0389 0.037
Leishmania major centrin, putative,caltractin, putative 0.0093 0.0389 0.0467
Brugia malayi hypothetical protein 0.0062 0.0228 0.0207
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0368 0.0816
Loa Loa (eye worm) hypothetical protein 0.0041 0.0116 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0031
Trypanosoma brucei Aph-1 protein, putative 0.0095 0.0396 0.0409
Plasmodium falciparum histone deacetylase 1 0.0089 0.0368 0.0834
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Entamoeba histolytica grainin, putative 0.0095 0.0398 0.0887
Loa Loa (eye worm) programmed cell death protein 6 0.0095 0.0398 0.0398
Plasmodium vivax unspecified product 0.0456 0.2283 0.5344
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0022
Loa Loa (eye worm) histone deacetylase 0.01 0.0425 0.0425
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0198 0.0935 0.0916
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0093 0.0389 0.0867
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.056 0.0541
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2283 0.5335
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2964 0.2949
Entamoeba histolytica cysteine proteinase, putative 0.0834 0.426 1
Leishmania major protein kinase, putative 0.0093 0.0389 0.0467
Echinococcus granulosus Glycosyl transferase family 35 0.0107 0.046 0.0441
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.046 0.0441
Onchocerca volvulus 0.0576 0.2912 0.3705
Brugia malayi Serine protease Z688.6 precursor 0.0023 0.0022 0.0001
Trichomonas vaginalis calpain, putative 0.0176 0.0823 0.189
Loa Loa (eye worm) fibroinase 0.0834 0.426 0.426
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0198 0.0935 0.2169
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0086 0.0349 0.0498
Loa Loa (eye worm) hypothetical protein 0.0258 0.125 0.125
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0116 0.0222
Brugia malayi Proteasome A-type and B-type family protein 0.0086 0.0349 0.0329
Loa Loa (eye worm) histone deacetylase 7A 0.01 0.0425 0.0425
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0093 0.0389 0.0368
Brugia malayi Trypsin family protein 0.0034 0.0082 0.0062
Mycobacterium tuberculosis Long conserved protein 0.0546 0.2755 0.4012
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Leishmania major histone deacetylase, putative 0.0089 0.0368 0.044
Trichomonas vaginalis calmodulin-2, putative 0.0093 0.0389 0.0867
Echinococcus granulosus calumenin 0.0095 0.0398 0.0378
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0823 0.189
Loa Loa (eye worm) hypothetical protein 0.0246 0.119 0.119
Plasmodium falciparum histone deacetylase 2 0.01 0.0425 0.0969
Toxoplasma gondii histone deacetylase HDAC3 0.0089 0.0368 0.0443
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0185 0.0871 0.2003
Mycobacterium leprae Conserved hypothetical protein 0.0546 0.2755 0.874
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0066 0.025 0.0229
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Trypanosoma brucei calpain, putative 0.0176 0.0823 0.0961
Toxoplasma gondii prolyl endopeptidase 0.1516 0.7824 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0116 0.0116
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.0228 0.0265
Loa Loa (eye worm) histone deacetylase 3 0.0089 0.0368 0.0368
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0565 0.0565
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0116 0.0096
Trypanosoma cruzi major cysteine proteinase, putative 0.0198 0.0935 0.0915
Echinococcus granulosus tumor protein p63 0.0356 0.1765 0.1748
Chlamydia trachomatis glycogen phosphorylase 0.0107 0.046 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0185 0.0871 0.2284
Plasmodium vivax unspecified product 0.0258 0.125 0.2911
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0136 0.0613 0.0594
Loa Loa (eye worm) calpain family protein 1 0.1144 0.5878 0.5878
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0082 0.0062
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.0349 0.0328
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0229 0.0209
Leishmania major cathepsin L-like protease 0.0934 0.4784 0.6102
Trypanosoma cruzi kinesin, putative 0.041 0.2044 0.2026
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0127 0.0105
Trypanosoma brucei I/6 autoantigen 0.0093 0.0389 0.0401
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0426 0.213 0.2113
Trypanosoma brucei protein I/6 0.0093 0.0389 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0934 0.4784 0.4773
Trypanosoma brucei centrin, putative 0.0093 0.0389 0.0401
Schistosoma mansoni hypothetical protein 0.0546 0.2755 0.2741
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0281 0.137 0.1727
Trypanosoma cruzi calmodulin, putative 0.0093 0.0389 0.0368
Brugia malayi Cytochrome P450 family protein 0.0034 0.0079 0.0058
Schistosoma mansoni hypothetical protein 0.0034 0.0082 0.0062
Loa Loa (eye worm) EF hand family protein 0.0093 0.0389 0.0389
Brugia malayi Papain family cysteine protease containing protein 0.0456 0.2283 0.2267
Trypanosoma cruzi cysteine proteinase, putative 0.0456 0.2283 0.2266
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0185 0.0871 0.1088
Entamoeba histolytica hypothetical protein 0.0198 0.0935 0.2155
Echinococcus granulosus EF hand domain containing family member A2 0.0093 0.0389 0.037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0935 0.0916
Giardia lamblia Hypothetical protein 0.0546 0.2755 0.7355
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0185 0.0871 0.2003
Trypanosoma brucei Calpain-like protein 1.2 0.0176 0.0823 0.0961
Plasmodium vivax serine-repeat antigen (SERA) 0.0198 0.0935 0.2169
Loa Loa (eye worm) hypothetical protein 0.0041 0.0116 0.0116
Onchocerca volvulus 0.0136 0.0613 0.0759
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0402 0.2004 0.1987
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Brugia malayi Trypsin family protein 0.0034 0.0082 0.0062
Onchocerca volvulus 0.0029 0.0052 0.004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Brugia malayi Cathepsin L-like precursor 0.0834 0.426 0.4248
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0089 0.0069
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0116 0.0096
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0025 0.0005
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0116 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0935 0.2155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Brugia malayi histone deacetylase 3 (HD3) 0.0089 0.0368 0.0348
Plasmodium falciparum histone deacetylase, putative 0.01 0.0425 0.0969
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0823 0.0961
Giardia lamblia Cathepsin L-like protease 0.0198 0.0935 0.2457
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0227 0.0207
Echinococcus granulosus histone deacetylase 6 0.0106 0.0458 0.0438
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0281 0.137 0.1351
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0052 0.0071
Onchocerca volvulus 0.0052 0.0175 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.3726
Echinococcus granulosus glycogen phosphorylase 0.0107 0.046 0.0441
Schistosoma mansoni Mername-AA248 (C02 family) 0.0586 0.2964 0.295
Schistosoma mansoni histone deacetylase 4 5 0.01 0.0425 0.0406
Echinococcus multilocularis cathepsin L cysteine protease 0.0834 0.426 0.4248
Entamoeba histolytica cysteine proteinase 2 0.0456 0.2283 0.5335
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0034 0.0082 0.0062
Loa Loa (eye worm) hypothetical protein 0.0198 0.0935 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0834 0.426 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0116 0.0222
Plasmodium falciparum serine repeat antigen 3 0.0198 0.0935 0.2169
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0456 0.2283 0.2266
Trypanosoma cruzi I/6 autoantigen, putative 0.0093 0.0389 0.0368
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.0117 0.0225
Leishmania major hypothetical protein, conserved 0.0036 0.0089 0.0082
Schistosoma mansoni histone deacetylase 1 2 3 0.0043 0.0127 0.0107
Loa Loa (eye worm) hypothetical protein 0.0136 0.0613 0.0613
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0025 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0198 0.0935 0.0916
Brugia malayi Thioredoxin family protein 0.0546 0.2755 0.2741
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0116 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Leishmania major cathepsin L-like protease 0.0834 0.426 0.543
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0281 0.137 0.1352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0385 0.0366
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.056 0.1744
Schistosoma mansoni histone deacetylase 0.0089 0.0368 0.0348
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0456 0.2283 0.2267
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0834 0.426 0.426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0086 0.0349 0.0772
Trichomonas vaginalis calcineurin B subunit, putative 0.0095 0.0398 0.0887
Echinococcus granulosus EF HAND 1 calcium binding site 0.0093 0.0389 0.037
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0389 0.037
Trypanosoma brucei kinesin, putative 0.041 0.2044 0.2537
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0089 0.0089
Echinococcus multilocularis calmodulin 0.0093 0.0389 0.037
Trypanosoma brucei oligopeptidase b 0.0621 0.3145 0.3959
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Loa Loa (eye worm) hypothetical protein 0.0198 0.0935 0.0935
Echinococcus multilocularis cpg binding protein 0.003 0.0058 0.0038
Leishmania major calpain family cysteine protease-like protein 0.0176 0.0823 0.1023
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0621 0.3145 0.4001
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0243 0.1169 0.1169
Onchocerca volvulus Cathepsin L homolog 0.0834 0.426 0.5432
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0079 0.0079
Echinococcus multilocularis prolyl endopeptidase 0.1516 0.7824 0.7819
Mycobacterium tuberculosis Conserved protein 0.0036 0.0089 0.0118
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0034 0.0082 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0089 0.0067
Schistosoma mansoni calmodulin 0.0093 0.0389 0.037
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.0117 0.0097
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0093 0.0389 0.0368
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1516 0.7824 0.7819
Echinococcus multilocularis calcium uptake protein 1 0.0095 0.0398 0.0378
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0456 0.2283 0.2267
Trichomonas vaginalis myosin light chain 1, putative 0.0093 0.0389 0.0867
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0093 0.0389 0.0884
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0031
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1647 0.8507 0.8504
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.056 0.069
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0185 0.0871 0.2003
Echinococcus multilocularis calpain 7 (C02 family) 0.0586 0.2964 0.295
Trichomonas vaginalis centrin, putative 0.0093 0.0389 0.0867
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.0089
Brugia malayi Trypsin family protein 0.0034 0.0082 0.0062
Brugia malayi Cathepsin L-like precursor 0.0834 0.426 0.4248
Loa Loa (eye worm) hypothetical protein 0.0185 0.0871 0.0871
Brugia malayi Cathepsin L-like precursor 0.0576 0.2912 0.2897
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0185 0.0871 0.0852
Echinococcus multilocularis Mastin 0.0034 0.0082 0.0062
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0116 0.0096
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0198 0.0935 0.2169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0935 0.0916
Echinococcus multilocularis Glycosyl transferase, family 35 0.0107 0.046 0.0441
Plasmodium falciparum proteasome subunit beta type-5 0.0086 0.0349 0.0789
Plasmodium falciparum calpain 0.0176 0.0823 0.1905
Brugia malayi calpain family protein 1 0.1554 0.802 0.8016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Echinococcus granulosus cysteine protease 0.0456 0.2283 0.2267
Giardia lamblia Cathepsin B precursor 0.0734 0.3739 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0198 0.0935 0.0916
Echinococcus multilocularis cathepsin L 0.0456 0.2283 0.2267
Echinococcus granulosus cpg binding protein 0.003 0.0058 0.0038
Plasmodium vivax proteasome subunit beta type-1, putative 0.0066 0.025 0.0555
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.0198 0.0935 0.0935
Leishmania major hypothetical protein, conserved 0.0093 0.0389 0.0467
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0185 0.0871 0.2003
Plasmodium vivax SET domain protein, putative 0.0063 0.0229 0.0506
Echinococcus granulosus cathepsin L cysteine proteinase 0.0834 0.426 0.4248
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Leishmania major proteasome beta 2 subunit, putative 0.0041 0.0117 0.0118
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.119 0.1172
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0116 0.0116
Entamoeba histolytica protein kinase, putative 0.041 0.2044 0.4771
Entamoeba histolytica cysteine protease, putative 0.0198 0.0935 0.2155
Mycobacterium ulcerans putative transglutaminase-like protein 0.0546 0.2755 0.8755
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Brugia malayi Cathepsin L-like precursor 0.0834 0.426 0.4248
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0089 0.0067
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2964 0.3726
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Onchocerca volvulus 0.0034 0.0082 0.0079
Trypanosoma cruzi centrin-3 0.0093 0.0389 0.0368
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.1933 1 1
Giardia lamblia Histone deacetylase 0.0089 0.0368 0.0931
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0089 0.012
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Plasmodium vivax vivapain-3 0.0456 0.2283 0.5344
Schistosoma mansoni cpg binding protein 0.003 0.0058 0.0038
Mycobacterium ulcerans hypothetical protein 0.0546 0.2755 0.8755
Schistosoma mansoni microtubule-associated protein tau 0.1456 0.7511 0.7506
Toxoplasma gondii calmodulin CAM1 0.0095 0.0398 0.0482
Toxoplasma gondii histone deacetylase HDAC5 0.0043 0.0128 0.0136
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0175 0.0175
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0089 0.0176
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Entamoeba histolytica cysteine protease, putative 0.0198 0.0935 0.2155
Schistosoma mansoni calpain-7 (C02 family) 0.0589 0.298 0.2965
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0116 0.0116
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0089 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0116 0.0222
Giardia lamblia Cysteine protease 0.0198 0.0935 0.2457
Leishmania major cathepsin L-like protease 0.0834 0.426 0.543
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0025 0.0026
Brugia malayi PXA domain containing protein 0.0041 0.0116 0.0096
Entamoeba histolytica hypothetical protein, conserved 0.0185 0.0871 0.2003
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0066 0.025 0.0228
Toxoplasma gondii hypothetical protein 0.0176 0.0823 0.1026
Echinococcus multilocularis histone deacetylase 0.01 0.0425 0.0406
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0116 0.0096
Trichomonas vaginalis calmodulin, putative 0.0095 0.0398 0.0887
Onchocerca volvulus 0.0036 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0062 0.0228 0.0228
Plasmodium vivax proteasome subunit beta type-2, putative 0.0041 0.0117 0.0243
Giardia lamblia Encystation-specific protease 0.0198 0.0935 0.2457
Echinococcus granulosus caspase 2 0.0062 0.0228 0.0207
Plasmodium vivax unspecified product 0.0198 0.0935 0.2169
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0198 0.0935 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0116 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Brugia malayi Pre-SET motif family protein 0.0432 0.216 0.2144
Schistosoma mansoni centrin 0.0093 0.0389 0.037
Leishmania major calmodulin-like protein 0.0093 0.0389 0.0467
Entamoeba histolytica cysteine proteinase 1, putative 0.0456 0.2283 0.5335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0052 0.0064
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0025 0.0004
Entamoeba histolytica cysteine protease, putative 0.0198 0.0935 0.2155
Mycobacterium tuberculosis Conserved protein 0.0036 0.0089 0.0118
Trichomonas vaginalis calcium binding proteins, putative 0.0093 0.0389 0.0867
Onchocerca volvulus 0.0834 0.426 0.5432
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0935 0.2155
Brugia malayi prolyl oligopeptidase family protein 0.0281 0.137 0.1352
Trypanosoma brucei Calpain-like protein 2 0.0176 0.0823 0.0961
Plasmodium falciparum peptidase, putative 0.0185 0.0871 0.2018
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0089 0.0118
Entamoeba histolytica calmodulin, putative 0.0093 0.0389 0.0867
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0385 0.0366
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0086 0.0349 0.088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0021 0.0021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Giardia lamblia Alanyl dipeptidyl peptidase 0.0185 0.0871 0.2284
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0565 0.0565
Mycobacterium tuberculosis Conserved hypothetical protein 0.0546 0.2755 0.4012
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0116 0.0096
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0136 0.0613 0.0594
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0935 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0456 0.2283 0.5335
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.0823 0.189
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0198 0.0935 0.0916
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Mycobacterium tuberculosis Conserved protein 0.0546 0.2755 0.4012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.0089
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0116 0.0096
Onchocerca volvulus 0.0036 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0063 0.0229 0.0229
Plasmodium falciparum serine repeat antigen 6 0.0198 0.0935 0.2169
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0425 0.0404
Brugia malayi prolyl oligopeptidase family protein 0.0185 0.0871 0.0852
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0089 0.0158
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0093 0.0389 0.0368
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.0228 0.0207
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0528 0.2659 0.3381
Loa Loa (eye worm) hypothetical protein 0.0198 0.0935 0.0935
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0021 0.0021
Brugia malayi Cathepsin L-like precursor 0.0834 0.426 0.4248
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0823 0.0803
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Entamoeba histolytica grainin 2 0.0093 0.0389 0.0867
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1933 1 1
Leishmania major i/6 autoantigen-like protein 0.0093 0.0389 0.0467
Trypanosoma brucei cysteine peptidase C (CPC) 0.0734 0.3739 0.4725
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2964 0.2949
Schistosoma mansoni survival motor neuron protein 0.005 0.0165 0.0145
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Loa Loa (eye worm) calpain D 0.0176 0.0823 0.0823
Brugia malayi Cathepsin L-like precursor 0.0834 0.426 0.4248
Onchocerca volvulus 0.0034 0.0082 0.0079
Echinococcus granulosus histone deacetylase 3 0.0089 0.0368 0.0348
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0198 0.0935 0.2169
Brugia malayi Papain family cysteine protease containing protein 0.0198 0.0935 0.0916
Loa Loa (eye worm) hypothetical protein 0.0062 0.0228 0.0228
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0116 0.0096
Schistosoma mansoni glycogen phosphorylase 0.0107 0.046 0.0441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.0935 0.2155
Echinococcus multilocularis centrin 2 0.0093 0.0389 0.037
Echinococcus granulosus transmembrane protease serine 3 0.0034 0.0082 0.0062
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0041 0.0117 0.0096
Onchocerca volvulus 0.0034 0.0082 0.0079
Brugia malayi EF hand family protein 0.0093 0.0389 0.037
Trypanosoma cruzi calmodulin, putative 0.0093 0.0389 0.0368
Schistosoma mansoni cpg binding protein 0.003 0.0058 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0834 0.426 1
Loa Loa (eye worm) hypothetical protein 0.1554 0.802 0.802
Echinococcus granulosus histone deacetylase 7 0.01 0.0425 0.0406
Plasmodium falciparum cysteine proteinase falcipain 1 0.0456 0.2283 0.5344
Loa Loa (eye worm) hypothetical protein 0.0198 0.0935 0.0935
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2283 0.5335
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0823 0.0803
Giardia lamblia Cathepsin B precursor 0.0198 0.0935 0.2457
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0198 0.0935 0.2457
Echinococcus multilocularis geminin 0.0169 0.0785 0.0766
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0823 0.0803
Echinococcus granulosus cathepsin b 0.1933 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0025 0.0025
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Plasmodium vivax histone deacetylase, putative 0.0043 0.0127 0.0266
Toxoplasma gondii cathepsin CPC2 0.0198 0.0935 0.117
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Plasmodium falciparum serine repeat antigen 1 0.0198 0.0935 0.2169
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.2912 0.6819
Entamoeba histolytica prolyl oligopeptidase family protein 0.0185 0.0871 0.2003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0229 0.0209
Echinococcus multilocularis EF hand domain containing family member A2 0.0093 0.0389 0.037
Brugia malayi calcium-binding protein 0.0093 0.0389 0.037
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0086 0.0349 0.0349
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0935 0.0916
Loa Loa (eye worm) hypothetical protein 0.0176 0.0823 0.0823
Giardia lamblia Cathepsin L-like protease 0.0198 0.0935 0.2457
Echinococcus granulosus cathepsin l1 0.0834 0.426 0.4248
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0528 0.2659 0.2643
Leishmania major kinesin, putative 0.041 0.2044 0.2588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0456 0.2283 0.2846
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0121
Brugia malayi cathepsin F-like cysteine proteinase 0.0198 0.0935 0.0916
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0198 0.0935 0.2169
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0396 0.0375
Trypanosoma brucei histone deacetylase 2 0.0043 0.0127 0.0062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0229 0.0209
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0823 0.0803
Trichomonas vaginalis centrin, putative 0.0093 0.0389 0.0867
Brugia malayi prolyl oligopeptidase family protein 0.1516 0.7824 0.7819
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0198 0.0935 0.2155
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0089 0.0158
Toxoplasma gondii histone deacetylase HDAC2 0.0089 0.0368 0.0443
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0093 0.0389 0.037
Plasmodium vivax histone deacetylase 2, putative 0.01 0.0425 0.0969
Trypanosoma cruzi histone deacetylase 1, putative 0.0089 0.0368 0.0347
Echinococcus granulosus cathepsin L 0.0456 0.2283 0.2267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.0935 0.2155
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1933 1 1
Leishmania major cysteine peptidase A (CPA) 0.0834 0.426 0.543
Giardia lamblia Transglutaminase/protease, putative 0.0546 0.2755 0.7355
Loa Loa (eye worm) hypothetical protein 0.0089 0.0368 0.0368
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0389 0.0867
Trypanosoma cruzi cruzipain precursor, putative 0.0258 0.125 0.1231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Trypanosoma brucei histone deacetylase 4 0.01 0.0425 0.0447
Schistosoma mansoni reticulocalbin 0.0093 0.0389 0.037
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Mycobacterium ulcerans proteasome PrcB 0.0086 0.0349 0.107
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0176 0.0823 0.0803
Onchocerca volvulus 0.0834 0.426 0.5432
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0528 0.2659 0.2643
Echinococcus multilocularis cathepsin L 0.0198 0.0935 0.0916
Brugia malayi Papain family cysteine protease containing protein 0.0834 0.426 0.4248
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.0228 0.0207
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Loa Loa (eye worm) calpain 0.0586 0.2964 0.2964
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0871 0.0851
Leishmania major cathepsin L-like protease 0.0834 0.426 0.543
Trypanosoma cruzi major cysteine proteinase, putative 0.0298 0.146 0.1441
Echinococcus multilocularis histone deacetylase 6 0.0106 0.0458 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.2949
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0116 0.0096
Entamoeba histolytica cysteine protease, putative 0.0198 0.0935 0.2155
Brugia malayi proteasome subunit beta type 2 0.0041 0.0117 0.0097
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.056 0.0541
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0621 0.3145 1
Schistosoma mansoni hypothetical protein 0.0093 0.0389 0.037
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0079 0.0079
Giardia lamblia Cathepsin L precursor 0.0198 0.0935 0.2457
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0089 0.0239
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0198 0.0935 0.0916
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0198 0.0935 0.2169
Schistosoma mansoni cathepsin s 0.0258 0.125 0.1232
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Mycobacterium ulcerans hypothetical protein 0.0546 0.2755 0.8755
Loa Loa (eye worm) proteasome subunit beta type 2 0.0041 0.0117 0.0117
Onchocerca volvulus Glycogen phosphorylase homolog 0.0107 0.046 0.0563
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0116 0.0096
Trypanosoma brucei antigen, putative 0.0586 0.2964 0.3726
Toxoplasma gondii ABC1 family protein 0.0036 0.0089 0.0086
Trypanosoma cruzi histone deacetylase 1, putative 0.0089 0.0368 0.0347
Trypanosoma brucei proteasome beta 6 subunit 0.0066 0.025 0.022
Echinococcus multilocularis transmembrane protease serine 3 0.0034 0.0082 0.0062
Echinococcus granulosus histone deacetylase 0.01 0.0425 0.0406
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0046 0.0144 0.0198
Trypanosoma brucei histone deacetylase, putative 0.01 0.0425 0.0447
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1933 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0198 0.0935 0.2155
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0052 0.0121
Brugia malayi cathepsin F-like cysteine proteinase 0.0258 0.125 0.1232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0368 0.0816
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.0934 0.4784 0.4773
Entamoeba histolytica calcium-binding protein, putative 0.0093 0.0389 0.0867
Plasmodium falciparum serine repeat antigen 2 0.0198 0.0935 0.2169
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0052 0.0064
Echinococcus granulosus histone deacetylase 6 0.01 0.0425 0.0406
Leishmania major centrin, putative 0.0093 0.0389 0.0467
Brugia malayi CXXC zinc finger family protein 0.0028 0.005 0.0029
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0086 0.0349 0.0961
Brugia malayi Cathepsin L-like cysteine proteinase 0.0576 0.2912 0.2897
Leishmania major phospholipase c-like protein 0.0093 0.0389 0.0467
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.119 0.1172
Echinococcus multilocularis histone deacetylase 8 0.0043 0.0127 0.0107
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.0117 0.0225
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0116 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0385 0.0366
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Onchocerca volvulus Cathepsin F homolog 0.0834 0.426 0.5432
Brugia malayi cathepsin L-like precursor 0.0576 0.2912 0.2897
Entamoeba histolytica calcium binding family protein 0.0093 0.0389 0.0867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0935 0.2155
Echinococcus multilocularis histone deacetylase 1 0.0089 0.0368 0.0348
Echinococcus granulosus cathepsin L 0.0198 0.0935 0.0916
Onchocerca volvulus 0.0028 0.005 0.0038
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0116 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0034
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0425 0.0404
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0116 0.0096
Toxoplasma gondii proteasome subunit beta type, putative 0.0086 0.0349 0.0419
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0198 0.0935 0.2155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0089 0.0069
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0734 0.3739 0.3725
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0086 0.0349 0.0329
Leishmania major oligopeptidase b 0.0621 0.3145 0.4001
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Trypanosoma cruzi oligopeptidase b 0.0621 0.3145 0.313
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0229 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0021 0.0021
Echinococcus granulosus inhibitor of apoptosis protein 0.0136 0.0613 0.0594
Onchocerca volvulus 0.0834 0.426 0.5432
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0089 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0229 0.0209
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0176 0.0823 0.0961
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Loa Loa (eye worm) hypothetical protein 0.0063 0.0234 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0116 0.0096
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0093 0.0389 0.0867
Trypanosoma cruzi oligopeptidase b 0.0621 0.3145 0.313
Schistosoma mansoni hypothetical protein 0.0093 0.0389 0.037
Schistosoma mansoni hypothetical protein 0.0169 0.0785 0.0766
Toxoplasma gondii cathepsin CPL 0.0834 0.426 0.5431
Schistosoma mansoni rab 0.0093 0.0389 0.037
Loa Loa (eye worm) hypothetical protein 0.0258 0.125 0.125
Brugia malayi PXA domain containing protein 0.0041 0.0116 0.0096
Mycobacterium tuberculosis Probable peptidase 0.0621 0.3145 0.4582
Leishmania major cathepsin L-like protease 0.0834 0.426 0.543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0116 0.0096
Toxoplasma gondii calcium-dependent protein kinase 0.0095 0.0398 0.0482
Loa Loa (eye worm) hypothetical protein 0.0576 0.2912 0.2912
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0116 0.0096
Echinococcus multilocularis calumenin 0.0095 0.0398 0.0378
Loa Loa (eye worm) beta-lactamase 0.0036 0.0089 0.0089
Trypanosoma brucei calpain, putative 0.0176 0.0823 0.0961
Leishmania major hypothetical protein, unknown function 0.0176 0.0823 0.1023
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0198 0.0935 0.2169
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0425 0.0404
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0834 0.426 0.4248
Echinococcus granulosus calmodulin 0.0093 0.0389 0.037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Toxoplasma gondii histone deacetylase HDAC4 0.0043 0.0127 0.0134
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0621 0.3145 0.313
Plasmodium vivax vivapain-2 0.0834 0.426 1
Brugia malayi Kringle domain containing protein 0.0024 0.0025 0.0005
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0389 0.0867
Loa Loa (eye worm) calpain family protein 1 0.1554 0.802 0.802
Toxoplasma gondii centrin, putative 0.0093 0.0389 0.0471
Echinococcus multilocularis inhibitor of apoptosis protein 0.0136 0.0613 0.0594
Onchocerca volvulus 0.0034 0.0082 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0389 0.0867
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.216 0.216
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0198 0.0935 0.0935
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0093 0.0389 0.0368
Onchocerca volvulus 0.0023 0.0022 0.0002
Plasmodium falciparum serine repeat antigen 8 0.0198 0.0935 0.2169
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0198 0.0935 0.2155
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Leishmania major calmodulin, putative 0.0093 0.0389 0.0467
Entamoeba histolytica cysteine protease, putative 0.0834 0.426 1
Schistosoma mansoni hypothetical protein 0.0024 0.0025 0.0005
Leishmania major histone deacetylase, putative 0.01 0.0425 0.0513
Brugia malayi Histone deacetylase 1 0.0089 0.0368 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0456 0.2283 0.5335
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0136 0.0613 0.0594
Echinococcus multilocularis calmodulin 0.0093 0.0389 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0229 0.0209
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0093 0.0389 0.0368
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2283 0.5335
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0116 0.0096
Brugia malayi calpain D 0.0176 0.0823 0.0804
Trichomonas vaginalis calcium binding protein, putative 0.0093 0.0389 0.0867
Mycobacterium tuberculosis Conserved hypothetical protein 0.0546 0.2755 0.4012
Brugia malayi Cytochrome P450 family protein 0.0034 0.0079 0.0058
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0198 0.0935 0.2155
Loa Loa (eye worm) calpain 5 0.041 0.2044 0.2044
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.046 0.1034
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0621 0.3145 0.4582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0385 0.0366
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0823 0.0803
Onchocerca volvulus 0.0739 0.3762 0.4794
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Echinococcus granulosus acylamino acid releasing enzyme 0.0185 0.0871 0.0852
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0066 0.025 0.0229
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0834 0.426 0.426
Giardia lamblia Hypothetical protein 0.0198 0.0935 0.2457
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.056 0.0806
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0368 0.0816
Echinococcus multilocularis acylamino acid releasing enzyme 0.0185 0.0871 0.0852
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0116 0.0096
Loa Loa (eye worm) hypothetical protein 0.0258 0.125 0.125
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0823 0.0803
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0676 0.3436 0.3422
Brugia malayi Cathepsin L-like precursor 0.0258 0.125 0.1232
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Giardia lamblia Cysteine protease 0.0198 0.0935 0.2457
Echinococcus multilocularis enteropeptidase 0.0034 0.0082 0.0062
Plasmodium vivax vivapain-1 0.0456 0.2283 0.5344
Giardia lamblia Cathepsin B precursor 0.0198 0.0935 0.2457
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2964 0.2949
Onchocerca volvulus 0.0024 0.0025 0.0006
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0198 0.0935 0.2169
Plasmodium falciparum serine repeat antigen 4 0.0198 0.0935 0.2169
Echinococcus granulosus cathepsin L cysteine protease 0.0456 0.2283 0.2267
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0222
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0144 0.0287
Plasmodium vivax centrin-1, putative 0.0093 0.0389 0.0884
Mycobacterium ulcerans hypothetical protein 0.0036 0.0089 0.0239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0456 0.2283 0.2846
Schistosoma mansoni cathepsin S (C01 family) 0.0198 0.0935 0.0916
Toxoplasma gondii cathepsin CPC1 0.0198 0.0935 0.117
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0144 0.0287
Toxoplasma gondii hypothetical protein 0.0185 0.0871 0.1088
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0086 0.0349 0.0349
Onchocerca volvulus 0.005 0.0165 0.0185
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Giardia lamblia Cathepsin B precursor 0.0198 0.0935 0.2457
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2964 0.2949
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0198 0.0935 0.0935
Echinococcus multilocularis proteasome (prosome, macropain) 0.0086 0.0349 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0385 0.0366
Schistosoma mansoni calmodulin 0.0093 0.0389 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0389 0.0867
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.0117 0.0097
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0176 0.0823 0.0803
Brugia malayi cathepsin L-like cysteine proteinase 0.0198 0.0935 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0935 0.2155
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0093 0.0389 0.0867
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0116 0.0222
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2283 0.5335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0089 0.0239
Loa Loa (eye worm) ctsf protein 0.0834 0.426 0.426
Schistosoma mansoni hypothetical protein 0.0176 0.0823 0.0804
Entamoeba histolytica calpain family cysteine protease, putative 0.0176 0.0823 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0734 0.3739 0.8771
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1647 0.8507 0.8504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0935 0.2155
Leishmania major calcineurin B subunit, putative 0.0093 0.0389 0.0467
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0222
Brugia malayi gamma-secretase subunit aph-1 0.0243 0.1169 0.1151
Onchocerca volvulus 0.0062 0.0228 0.0265
Plasmodium vivax vivapain-2 0.0834 0.426 1
Toxoplasma gondii EF hand domain-containing protein 0.0093 0.0389 0.0471
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0136 0.0613 0.0594
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.0089
Giardia lamblia Glycogen phosphorylase 0.0107 0.046 0.1179
Entamoeba histolytica calmodulin, putative 0.0093 0.0389 0.0867
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0116 0.0096
Trichomonas vaginalis esterase, putative 0.0036 0.0089 0.0158
Plasmodium vivax proteasome subunit beta type-5, putative 0.0086 0.0349 0.0789
Brugia malayi beta-lactamase family protein 0.0036 0.0089 0.0069
Onchocerca volvulus Prolyl endopeptidase homolog 0.1516 0.7824 1
Mycobacterium leprae Conserved hypothetical protein 0.0546 0.2755 0.874
Schistosoma mansoni histone deacetylase hda2 0.0106 0.0458 0.0438
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0281 0.137 0.1667
Trypanosoma brucei prolyl endopeptidase 0.1516 0.7824 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0528 0.2659 0.2643
Mycobacterium ulcerans lipase LipD 0.0036 0.0089 0.0239
Trypanosoma cruzi conserved protein 0.0176 0.0823 0.0803
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0175 0.0155
Plasmodium falciparum cysteine proteinase falcipain 3 0.0834 0.426 1
Brugia malayi Serine protease Z688.6 precursor 0.0023 0.0022 0.0001
Echinococcus multilocularis tumor protein p63 0.0356 0.1765 0.1748
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0734 0.3739 0.3726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Leishmania major calpain protease-like protein 0.0176 0.0823 0.1023
Echinococcus granulosus cathepsin b 0.1933 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0079 0.0057
Toxoplasma gondii EFHC1, putative 0.0093 0.0389 0.0471
Leishmania major cytochrome p450-like protein 0.0034 0.0079 0.0069
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0198 0.0935 0.0916
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0176 0.0823 0.0961
Brugia malayi histone deacetylase 1 (HD1) 0.0089 0.0368 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0198 0.0935 0.2457
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0066 0.025 0.0288
Echinococcus granulosus dnaJ subfamily B 0.0402 0.2004 0.1987
Trypanosoma cruzi kinesin, putative 0.041 0.2044 0.2026
Entamoeba histolytica calpain large subunit domain III containing protein 0.041 0.2044 0.4771
Echinococcus multilocularis glycoprotein Antigen 5 0.0034 0.0082 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0398 0.0904
Plasmodium vivax histone deacetylase 1, putative 0.0089 0.0368 0.0834
Trichomonas vaginalis set domain proteins, putative 0.0492 0.2472 0.5781
Echinococcus multilocularis programmed cell death protein 0.0093 0.0389 0.037
Loa Loa (eye worm) hypothetical protein 0.0136 0.0613 0.0613
Schistosoma mansoni hypothetical protein 0.0136 0.0613 0.0594
Echinococcus multilocularis histone deacetylase 6 0.01 0.0425 0.0406
Schistosoma mansoni calmodulin related calcium binding protein 0.0093 0.0389 0.037
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Schistosoma mansoni glycogen phosphorylase 0.0107 0.046 0.0441
Brugia malayi histone deacetylase 11 0.0043 0.0127 0.0107
Trichomonas vaginalis calpain, putative 0.0176 0.0823 0.189
Plasmodium falciparum centrin-1 0.0093 0.0389 0.0884
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0052 0.0121
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.3769
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1933 1 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0185 0.0871 0.0852
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0823 0.189
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0198 0.0935 0.2169
Entamoeba histolytica glycogenphosphorylase, putative 0.0046 0.0144 0.0287
Echinococcus multilocularis cysteine protease 0.0834 0.426 0.4248
Brugia malayi fibroinase precursor 0.0198 0.0935 0.0916
Giardia lamblia Proteasome subunit beta type 1 0.0066 0.025 0.0612
Schistosoma mansoni cpg binding protein 0.0028 0.005 0.0029
Brugia malayi hypothetical protein 0.0041 0.0116 0.0096
Onchocerca volvulus Cathepsin L homolog 0.0834 0.426 0.5432
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0368 0.0816
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0456 0.2283 0.2267
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0935 0.2155
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0116 0.0116
Trypanosoma brucei calmodulin, putative 0.0095 0.0398 0.0412
Giardia lamblia Cathepsin B precursor 0.0198 0.0935 0.2457
Brugia malayi hypothetical protein 0.0159 0.0735 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0935 0.2155
Loa Loa (eye worm) hypothetical protein 0.0041 0.0116 0.0116
Trypanosoma cruzi centrin, putative 0.0093 0.0389 0.0368
Brugia malayi prolyl oligopeptidase family protein 0.0528 0.2659 0.2643
Brugia malayi calpain 7 0.0586 0.2964 0.295
Echinococcus granulosus calbindin 32 0.0095 0.0398 0.0378
Entamoeba histolytica histone deacetylase, putative 0.0089 0.0368 0.0816
Echinococcus multilocularis programmed cell death protein 0.0093 0.0389 0.037
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2964 0.3726
Entamoeba histolytica hypothetical protein, conserved 0.0095 0.0398 0.0887
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0116 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0116 0.0096
Brugia malayi carbohydrate phosphorylase 0.0107 0.046 0.0441
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0176 0.0823 0.0803
Schistosoma mansoni mitochondrial solute carrier 0.0093 0.0389 0.037
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0116 0.0116
Trypanosoma cruzi cysteine peptidase, putative 0.0834 0.426 0.4247
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0823 0.189
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0258 0.125 0.125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0935 0.2155
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Mycobacterium ulcerans beta-lactamase 0.0036 0.0089 0.0239
Echinococcus granulosus expressed protein 0.0797 0.4064 0.4052
Toxoplasma gondii preprocathepsin c precursor, putative 0.0198 0.0935 0.117
Loa Loa (eye worm) glycogen phosphorylase 0.0107 0.046 0.046
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.3769
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0046 0.0144 0.0413
Loa Loa (eye worm) histone deacetylase 11 0.0043 0.0127 0.0127
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0089 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0385 0.0385
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0198 0.0935 0.2169
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.046 0.0441
Schistosoma mansoni cathepsin F (C01 family) 0.0834 0.426 0.4248
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0095 0.0398 0.0378
Echinococcus granulosus histone deacetylase 6 0.01 0.0425 0.0406
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0116 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0021 0.0021
Trichomonas vaginalis calmodulin, putative 0.0093 0.0389 0.0867
Entamoeba histolytica cysteine protease, putative 0.0198 0.0935 0.2155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Echinococcus granulosus prolyl endopeptidase 0.1516 0.7824 0.7819
Trypanosoma cruzi caltractin, putative 0.0093 0.0389 0.0368
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0834 0.426 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0089 0.0158
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0034 0.0082 0.0062
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0368 0.0816
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0116 0.0096
Giardia lamblia Cathepsin L precursor 0.0198 0.0935 0.2457
Brugia malayi calpain 5 0.041 0.2044 0.2027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0089 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Schistosoma mansoni inhibitor of apoptosis protein 0.0136 0.0613 0.0594
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0089 0.0118
Entamoeba histolytica prolyl oligopeptidase family protein 0.0185 0.0871 0.2003
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0116 0.0116
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0093 0.0389 0.0867
Echinococcus granulosus histone deacetylase 8 0.0043 0.0127 0.0107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.0089
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0116 0.0096
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Toxoplasma gondii troponin c, isotype gamma, putative 0.0093 0.0389 0.0471
Loa Loa (eye worm) hypothetical protein 0.0093 0.0389 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0021 0.0021
Onchocerca volvulus 0.0834 0.426 0.5432
Giardia lamblia Cysteine protease 0.0198 0.0935 0.2457
Schistosoma mansoni ef hand domain family member A2 0.0093 0.0389 0.037
Loa Loa (eye worm) hypothetical protein 0.1144 0.5878 0.5878
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0586 0.2964 0.3726
Onchocerca volvulus 0.0093 0.0389 0.0473
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Leishmania major hypothetical protein, conserved 0.0176 0.0823 0.1023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0052
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Entamoeba histolytica cysteine proteinase, putative 0.0834 0.426 1
Brugia malayi EF hand family protein 0.0095 0.0398 0.0378
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0082 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0121
Giardia lamblia Hypothetical protein 0.0198 0.0935 0.2457
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0823 0.189
Loa Loa (eye worm) hypothetical protein 0.0093 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0082
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.2949
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0116 0.0222
Schistosoma mansoni cathepsin B (C01 family) 0.0198 0.0935 0.0916
Onchocerca volvulus 0.0034 0.0082 0.0079
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0116 0.0096
Onchocerca volvulus 0.0036 0.0089 0.0088
Schistosoma mansoni centrin-related 0.0093 0.0389 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0021 0.0021
Leishmania major calmodulin, putative 0.0093 0.0389 0.0467
Echinococcus multilocularis expressed protein 0.0797 0.4064 0.4052
Brugia malayi calpain family protein 1 0.1554 0.802 0.8016
Echinococcus multilocularis calpain 5 0.0586 0.2964 0.295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0834 0.426 1
Brugia malayi programmed cell death protein 6 0.0093 0.0389 0.037
Schistosoma mansoni calpain C (C02 family) 0.0586 0.2964 0.295
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0198 0.0935 0.2169
Loa Loa (eye worm) prolyl oligopeptidase 0.0185 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0052
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0023 0.0022 0.0001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Trypanosoma cruzi cysteine peptidase, putative 0.0934 0.4784 0.4773
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0093 0.0389 0.0401
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0586 0.2964 0.3769
Echinococcus granulosus calpain A 0.0586 0.2964 0.295
Trypanosoma cruzi cruzipain precursor, putative 0.0934 0.4784 0.4773
Mycobacterium ulcerans hypothetical protein 0.0029 0.0052 0.0121
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0089 0.0118
Echinococcus granulosus enteropeptidase 0.0034 0.0082 0.0062
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.046 0.1034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Echinococcus multilocularis gamma secretase subunit aph 1 0.0243 0.1169 0.1151
Trichomonas vaginalis calpain, putative 0.0176 0.0823 0.189
Schistosoma mansoni memapsin-2 (A01 family) 0.0444 0.2223 0.2207
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0052 0.0071
Trypanosoma cruzi 20S proteasome subunit 0.0041 0.0117 0.0096
Brugia malayi Histone deacetylase family protein 0.01 0.0425 0.0406
Onchocerca volvulus 0.0034 0.0082 0.0079
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0734 0.3739 0.4762
Echinococcus granulosus programmed cell death protein 0.0093 0.0389 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.0935 0.2155
Brugia malayi Calmodulin-like protein 0.0093 0.0389 0.037
Giardia lamblia Cathepsin B precursor 0.0734 0.3739 1
Leishmania major histone deacetylase, putative 0.01 0.0425 0.0513
Trypanosoma brucei centrin-3 0.0093 0.0389 0.0401
Echinococcus granulosus microtubule associated protein 2 0.1456 0.7511 0.7506
Leishmania major cathepsin L-like protease 0.0934 0.4784 0.6102
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0041 0.0117 0.0225
Onchocerca volvulus 0.0834 0.426 0.5432
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.046 0.1034
Trypanosoma brucei centrin, putative 0.0093 0.0389 0.0401
Trypanosoma cruzi calmodulin, putative 0.0093 0.0389 0.0368
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0116 0.0096
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0116 0.0096
Trypanosoma brucei calpain-like protein, putative 0.0586 0.2964 0.3726
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.056 0.0686
Echinococcus granulosus glycoprotein Antigen 5 0.0034 0.0082 0.0062
Brugia malayi Histone deacetylase family protein 0.01 0.0425 0.0406
Schistosoma mansoni histone deacetylase 4 5 0.01 0.0425 0.0406
Echinococcus granulosus EF hand domain containing family member A2 0.0095 0.0398 0.0378
Trypanosoma brucei Component of motile flagella 41 0.0093 0.0389 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0198 0.0935 0.2155
Schistosoma mansoni neuronal calcium sensor 0.0093 0.0389 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0116 0.0222
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0041 0.0117 0.0122
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0834 0.426 1
Mycobacterium tuberculosis Hypothetical protein 0.0546 0.2755 0.4012
Onchocerca volvulus 0.0063 0.0229 0.0267
Echinococcus multilocularis calpain A 0.1649 0.8515 0.8512
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0066 0.025 0.0228
Toxoplasma gondii cathepsin B 0.0734 0.3739 0.4764
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0586 0.2964 0.2949
Loa Loa (eye worm) hypothetical protein 0.0041 0.0116 0.0116
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0116 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0385 0.0366
Leishmania major calmodulin-like protein 0.0093 0.0389 0.0467
Echinococcus granulosus centrin 2 0.0093 0.0389 0.037
Leishmania major centrin, putative 0.0093 0.0389 0.0467
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0258 0.125 0.1232
Toxoplasma gondii histone deacetylase HDAC1 0.01 0.0425 0.0517
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0368 0.0816
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0176 0.0823 0.189
Trypanosoma brucei Calpain-like protein 1.1 0.0176 0.0823 0.0961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0834 0.426 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0198 0.0935 0.0916
Echinococcus multilocularis microtubule associated protein 2 0.1456 0.7511 0.7506
Brugia malayi hypothetical protein 0.0041 0.0116 0.0096
Giardia lamblia Proteasome subunit beta type 2 0.0041 0.0117 0.0257
Echinococcus granulosus proteasome prosome macropain 0.0086 0.0349 0.0329
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0198 0.0935 0.2169
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0136 0.0613 0.0594
Schistosoma mansoni hypothetical protein 0.0034 0.0082 0.0062
Echinococcus granulosus cathepsin l cysteine peptidase 0.0834 0.426 0.4248
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0066 0.025 0.0555
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0034
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0082 0.0062
Brugia malayi Pre-SET motif family protein 0.0063 0.0229 0.0209
Leishmania major cathepsin L-like protease 0.0934 0.4784 0.6102
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1516 0.7824 0.7819
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0229 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0935 0.2155
Echinococcus multilocularis cathepsin b 0.1933 1 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0621 0.3145 0.313
Loa Loa (eye worm) hypothetical protein 0.0576 0.2912 0.2912
Trypanosoma cruzi I/6 autoantigen, putative 0.0093 0.0389 0.0368
Trypanosoma brucei cysteine peptidase, putative 0.0176 0.0823 0.0961
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.0803
Echinococcus multilocularis cysteine protease 0.0834 0.426 0.4248
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0116 0.0096
Loa Loa (eye worm) hypothetical protein 0.0057 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Trypanosoma brucei histone deacetylase 3 0.01 0.0425 0.0447
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.2964 0.2949
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0116 0.0096
Trypanosoma brucei caltractin, putative 0.0093 0.0389 0.0401
Onchocerca volvulus 0.0834 0.426 0.5432
Mycobacterium ulcerans transglutaminase family protein 0.0546 0.2755 0.8755
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0194 0.0194
Leishmania major programmed cell death 6 protein-like protein 0.0093 0.0389 0.0467
Giardia lamblia Cysteine protease 0.0198 0.0935 0.2457
Echinococcus granulosus Dipeptidyl peptidase 9 0.0281 0.137 0.1352
Echinococcus multilocularis histone deacetylase 6 0.01 0.0425 0.0406
Echinococcus granulosus calcium uptake protein 1 0.0095 0.0398 0.0378
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0176 0.0823 0.1026
Mycobacterium tuberculosis Conserved protein 0.0036 0.0089 0.0118
Onchocerca volvulus 0.0095 0.0398 0.0484
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0426 0.213 0.2113
Echinococcus granulosus calpain 5 0.0586 0.2964 0.295
Entamoeba histolytica cysteine protease, putative 0.0456 0.2283 0.5335
Onchocerca volvulus 0.0159 0.0735 0.0916
Schistosoma mansoni calpain (C02 family) 0.0586 0.2964 0.295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2912 0.6819
Loa Loa (eye worm) hypothetical protein 0.0041 0.0116 0.0116
Leishmania major proteasome beta 5 subunit, putative 0.0086 0.0349 0.0415
Schistosoma mansoni cathepsin C 0.0198 0.0935 0.0916
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.056 0.0541
Plasmodium vivax histone deacetylase, putative 0.01 0.0425 0.0969
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0066 0.025 0.0537
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0229 0.0209
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.0089
Echinococcus granulosus neuronal calcium sensor 0.0093 0.0389 0.037
Brugia malayi Papain family cysteine protease containing protein 0.0456 0.2283 0.2267
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0093 0.0389 0.037
Echinococcus granulosus cathepsin l1 0.0576 0.2912 0.2897
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0368 0.0816
Echinococcus granulosus Mastin 0.0034 0.0082 0.0062
Echinococcus multilocularis neurocalcin 0.0093 0.0389 0.037
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0041 0.0117 0.005
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.046 0.1034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0871 0.2018
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0198 0.0935 0.0916
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0385 0.0366
Brugia malayi beta-lactamase 0.0036 0.0089 0.0069
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0621 0.3145 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0089 0.0013
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0093 0.0389 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0934 0.4784 0.6075
Brugia malayi Papain family cysteine protease containing protein 0.0198 0.0935 0.0916
Loa Loa (eye worm) hypothetical protein 0.1378 0.7099 0.7099
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0127 0.0107
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Echinococcus granulosus calpain A 0.1649 0.8515 0.8512
Brugia malayi cathepsin L precursor 0.0198 0.0935 0.0916
Brugia malayi cathepsin Z-like cysteine proteinase 0.0198 0.0935 0.0916
Echinococcus multilocularis calpain 0.0586 0.2964 0.295
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0176 0.0823 0.1023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0089 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0089 0.0069
Trichomonas vaginalis hypothetical protein 0.0176 0.0823 0.189
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0066 0.025 0.0292
Loa Loa (eye worm) hypothetical protein 0.1516 0.7824 0.7824
Echinococcus multilocularis cathepsin b 0.1933 1 1
Brugia malayi Trypsin family protein 0.0034 0.0082 0.0062
Giardia lamblia Cathepsin L precursor 0.0198 0.0935 0.2457

Activities

Activity type Activity value Assay description Source Reference
AbsAC40_uM (functional) > 26 uM PUBCHEM_BIOASSAY: Sustained Induction of HSF-1 Measured in Cell-Based System Using Plate Reader - 2038-07_Activator_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) > 260 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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