Detailed information for compound 1414270

Basic information

Technical information
  • TDR Targets ID: 1414270
  • Name: [4-(2-fluorophenyl)piperazin-1-yl]-(1-thiophe n-2-ylsulfonylpiperidin-3-yl)methanone
  • MW: 437.551 | Formula: C20H24FN3O3S2
  • H donors: 0 H acceptors: 3 LogP: 2.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN(C1)S(=O)(=O)c1cccs1)N1CCN(CC1)c1ccccc1F
  • InChi: 1S/C20H24FN3O3S2/c21-17-6-1-2-7-18(17)22-10-12-23(13-11-22)20(25)16-5-3-9-24(15-16)29(26,27)19-8-4-14-28-19/h1-2,4,6-8,14,16H,3,5,9-13,15H2
  • InChiKey: TXXMYSJFAXIDHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-(2-fluorophenyl)piperazin-1-yl]-[1-(2-thienylsulfonyl)-3-piperidyl]methanone
  • [4-(2-fluorophenyl)-1-piperazinyl]-[1-(2-thienylsulfonyl)-3-piperidinyl]methanone
  • C259-0962
  • NCGC00106477-01
  • EU-0091010

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi kinesin, putative 0.08 0.1868 0.1868
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.2649
Entamoeba histolytica cysteine proteinase, putative 0.0566 0.1309 0.7005
Trichomonas vaginalis hypothetical protein 0.0327 0.0739 0.2131
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0006 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0387 0.1116
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0034 0.004 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0464 0.1065 0.1065
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.7586
Brugia malayi calpain 5 0.0327 0.0739 0.0739
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0179 0.0384 0.0384
Trypanosoma cruzi kinesin, putative 0.08 0.1868 0.1868
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Giardia lamblia Cathepsin L precursor 0.0245 0.0542 0.1561
Onchocerca volvulus 0.0785 0.1832 0.4094
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0785 0.1832 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0179 0.0384 0.145
Leishmania major protein kinase, putative 0.0179 0.0384 0.11
Giardia lamblia Cathepsin B precursor 0.0245 0.0542 0.1561
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.1907 0.1907
Trypanosoma brucei Calpain-like protein 1.1 0.0327 0.0739 0.2116
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0246 0.08
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0246 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0101 0.0101
Trichomonas vaginalis calcium binding proteins, putative 0.0179 0.0384 0.1108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.147 0.3467 0.3467
Leishmania major phospholipase c-like protein 0.0179 0.0384 0.11
Entamoeba histolytica cysteine proteinase 2 0.0464 0.1065 0.5698
Echinococcus multilocularis Mastin 0.0071 0.0126 0.0126
Brugia malayi calpain 5 0.08 0.1868 0.1868
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Leishmania major cathepsin L-like protease 0.0879 0.2057 0.5888
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0034 0.0034
Brugia malayi beta-lactamase family protein 0.0037 0.0047 0.0047
Brugia malayi calpain 7 0.1127 0.2649 0.2649
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0219 0.0481 0.0481
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0006 0.0006
Echinococcus multilocularis acylamino acid releasing enzyme 0.018 0.0387 0.0387
Trypanosoma brucei Calpain-like protein 2 0.0327 0.0739 0.2116
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0047 0.0326
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0268 0.0598 0.1712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0245 0.0542 0.1564
Loa Loa (eye worm) hypothetical protein 0.0245 0.0542 0.0542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0246 0.1747
Plasmodium falciparum serine repeat antigen 4 0.0245 0.0542 0.296
Onchocerca volvulus 0.0566 0.1309 0.2922
Giardia lamblia Cathepsin L-like protease 0.0245 0.0542 0.1561
Brugia malayi Papain family cysteine protease containing protein 0.0245 0.0542 0.0542
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0464 0.1065 0.1065
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Echinococcus granulosus cathepsin L 0.0464 0.1065 0.1065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0006 0.0006
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0049 0.0049
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0039 0.005 0.0262
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0179 0.0384 0.0384
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0245 0.0542 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0006 0.0006
Schistosoma mansoni calmodulin 0.0179 0.0384 0.0384
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0245 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0126
Trypanosoma cruzi cruzipain precursor, putative 0.0879 0.2057 0.2057
Entamoeba histolytica cysteine protease, putative 0.0245 0.0542 0.2897
Plasmodium falciparum GPI-anchor transamidase, putative 0.0034 0.004 0.022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0001 0.0004
Onchocerca volvulus 0.0049 0.0075 0.0157
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0006 0.0006
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0365 0.083 0.083
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0327 0.0739 0.2131
Entamoeba histolytica cysteine proteinase, putative 0.0785 0.1832 0.9805
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0245 0.0542 0.1564
Brugia malayi calpain family protein 1 0.3016 0.7159 0.7159
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0062 0.0107 0.0107
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0179 0.0384 0.0384
Brugia malayi GPI-anchor transamidase 0.0034 0.004 0.004
Echinococcus granulosus Dipeptidyl peptidase 9 0.0268 0.0598 0.0598
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0268 0.0598 0.1712
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0245 0.0542 0.0542
Trypanosoma brucei Calpain-like protein 1.2 0.0327 0.0739 0.2116
Mycobacterium ulcerans hypothetical protein 0.0037 0.0047 0.0326
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0464 0.1065 0.3072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0071 0.0071
Loa Loa (eye worm) calpain 0.1127 0.2649 0.2649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0245 0.0542 0.1564
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0179 0.0384 0.0384
Giardia lamblia Cathepsin B precursor 0.0245 0.0542 0.1561
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Loa Loa (eye worm) peptidase C13 family protein 0.0149 0.0313 0.0313
Brugia malayi Trypsin family protein 0.0071 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Trichomonas vaginalis centrin, putative 0.0179 0.0384 0.1108
Onchocerca volvulus 0.1889 0.4468 1
Onchocerca volvulus Cell death protein 3 homolog 0.0154 0.0325 0.0718
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0049 0.0049
Brugia malayi nuclear receptor NHR-88 0.002 0.0006 0.0006
Echinococcus multilocularis GPI anchor transamidase 0.0034 0.004 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0302 0.0302
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0005 0.0005
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0005 0.0019
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.148 0.3493 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.008 0.015 0.0564
Brugia malayi Cathepsin L-like precursor 0.0785 0.1832 0.1832
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0327 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0219 0.0481 0.0481
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0605 0.1403 0.1403
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0245 0.0542 0.296
Schistosoma mansoni calpain-7 (C02 family) 0.1127 0.2649 0.2649
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0245 0.0542 0.1564
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0006 0.0006
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0011 0.003
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.008 0.015 0.015
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0605 0.1403 0.4017
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0245 0.0542 0.1564
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0006 0.0006
Onchocerca volvulus 0.0245 0.0542 0.1204
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3194 0.7585 0.7585
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0179 0.0384 0.11
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.0245 0.0542 0.2897
Trypanosoma cruzi cysteine peptidase, putative 0.0785 0.1832 0.1832
Brugia malayi Proteasome A-type and B-type family protein 0.008 0.015 0.015
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0034 0.004 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Brugia malayi cathepsin L-like cysteine proteinase 0.0245 0.0542 0.0542
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0006 0.0003
Echinococcus multilocularis calmodulin 0.0179 0.0384 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0464 0.1065 0.305
Loa Loa (eye worm) hypothetical protein 0.0149 0.0315 0.0315
Trypanosoma cruzi major cysteine proteinase, putative 0.0339 0.0767 0.0767
Trypanosoma cruzi cysteine peptidase, putative 0.0879 0.2057 0.2057
Plasmodium falciparum serine repeat antigen 3 0.0245 0.0542 0.296
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Giardia lamblia Cathepsin B precursor 0.0245 0.0542 0.1561
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0245 0.0542 0.0542
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.005 0.0145
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0049
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.005 0.0145
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0245 0.0542 0.296
Entamoeba histolytica prolyl oligopeptidase family protein 0.018 0.0387 0.2065
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0049 0.0049
Schistosoma mansoni cathepsin F (C01 family) 0.0566 0.1309 0.1309
Trypanosoma brucei centrin, putative 0.0179 0.0384 0.11
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0245 0.0542 0.1564
Plasmodium vivax unspecified product 0.0219 0.0481 0.1815
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0001 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0101 0.0101
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0245 0.0542 0.0542
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0245 0.0542 0.1561
Trypanosoma brucei proteasome subunit beta type-5, putative 0.008 0.015 0.0428
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0005 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0006 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0034 0.0034
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0049 0.0049
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0049 0.0049
Trypanosoma brucei centrin-3 0.0186 0.0402 0.115
Echinococcus granulosus centrin 2 0.0179 0.0384 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0014
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0496 0.1143 0.1143
Brugia malayi prolyl oligopeptidase family protein 0.148 0.3493 0.3493
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Brugia malayi Cytochrome P450 family protein 0.0032 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.4205 1 1
Onchocerca volvulus 0.0071 0.0126 0.0272
Onchocerca volvulus 0.0179 0.0384 0.085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0006 0.0006
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Trypanosoma brucei prolyl oligopeptidase, putative 0.0605 0.1403 0.4017
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1127 0.2649 0.2649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0464 0.1065 0.305
Loa Loa (eye worm) prolyl oligopeptidase 0.0496 0.1143 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0006 0.0006
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0179 0.0384 0.2051
Schistosoma mansoni neuronal calcium sensor 0.0179 0.0384 0.0384
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0049 0.0049
Echinococcus granulosus calcium uptake protein 1 0.0181 0.0391 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0245 0.0542 0.1564
Brugia malayi Cytochrome P450 family protein 0.0052 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0143
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0006 0.0003
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0245 0.0542 0.2047
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1127 0.2649 0.2649
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0005 0.0005
Trichomonas vaginalis esterase, putative 0.0037 0.0047 0.0136
Mycobacterium ulcerans beta-lactamase 0.0037 0.0047 0.0326
Brugia malayi cathepsin F-like cysteine proteinase 0.0245 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0785 0.1832 0.5283
Giardia lamblia Cathepsin L precursor 0.0245 0.0542 0.1561
Plasmodium vivax vivapain-1 0.0464 0.1065 0.402
Loa Loa (eye worm) hypothetical protein 0.3016 0.7159 0.7159
Schistosoma mansoni centrin-related 0.0179 0.0384 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Schistosoma mansoni caspase-7 (C14 family) 0.0154 0.0325 0.0325
Schistosoma mansoni hemoglobinase (C13 family) 0.0149 0.0313 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0014
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.002 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0245 0.0542 0.1564
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0605 0.1403 0.1403
Schistosoma mansoni hypothetical protein 0.0327 0.0739 0.0739
Trypanosoma brucei calpain, putative 0.0327 0.0739 0.2116
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Brugia malayi Pre-SET motif family protein 0.0414 0.0947 0.0947
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0006 0.0006
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0049 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0001 0.0001
Echinococcus granulosus cathepsin b 0.4205 1 1
Trichomonas vaginalis calcium binding protein, putative 0.0186 0.0402 0.1159
Echinococcus granulosus acylamino acid releasing enzyme 0.018 0.0387 0.0387
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0245 0.0542 0.2047
Plasmodium vivax serine-repeat antigen (SERA) 0.0245 0.0542 0.2047
Echinococcus granulosus programmed cell death protein 0.0186 0.0402 0.0402
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.0947 0.0947
Trypanosoma cruzi Aph-1 protein, putative 0.0099 0.0194 0.0194
Schistosoma mansoni calpain-7 (C02 family) 0.1127 0.2649 0.2649
Plasmodium vivax hypothetical protein, conserved 0.0181 0.0391 0.1477
Schistosoma mansoni thyroid hormone receptor 0.002 0.0006 0.0006
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4205 1 1
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0001 0.0001
Giardia lamblia Cysteine protease 0.0245 0.0542 0.1561
Trypanosoma cruzi cysteine protease, putative 0.0464 0.1065 0.1065
Giardia lamblia Proteasome subunit beta type 2 0.0039 0.005 0.0141
Echinococcus multilocularis cpg binding protein 0.0029 0.0028 0.0028
Giardia lamblia Encystation-specific protease 0.0245 0.0542 0.1561
Echinococcus multilocularis inhibitor of apoptosis protein 0.0179 0.0386 0.0386
Brugia malayi Calmodulin-like protein 0.0179 0.0384 0.0384
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.0739 0.0739
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0006 0.0006
Leishmania major proteasome beta 2 subunit, putative 0.0039 0.005 0.0144
Echinococcus granulosus proteasome prosome macropain 0.008 0.015 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0047 0.0047
Echinococcus granulosus cathepsin l1 0.0566 0.1309 0.1309
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0011 0.004
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Plasmodium falciparum serine repeat antigen 5 0.0245 0.0542 0.296
Echinococcus granulosus dnaJ subfamily B 0.0395 0.0902 0.0902
Loa Loa (eye worm) programmed cell death protein 6 0.0181 0.0391 0.0391
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.0245 0.0542 0.2897
Leishmania major i/6 autoantigen-like protein 0.0179 0.0384 0.11
Onchocerca volvulus 0.0037 0.0047 0.0095
Loa Loa (eye worm) proteasome subunit beta type 2 0.0039 0.005 0.005
Trichomonas vaginalis calpain, putative 0.0327 0.0739 0.2131
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0268 0.0598 0.1712
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.018 0.0387 0.1108
Schistosoma mansoni Mername-AA248 (C02 family) 0.1127 0.2649 0.2649
Echinococcus granulosus caspase 8 0.0018 0.000000009827 0.000000009827
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0049 0.0049
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0785 0.1832 0.1832
Schistosoma mansoni cathepsin F (C01 family) 0.0785 0.1832 0.1832
Loa Loa (eye worm) EF hand family protein 0.0179 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3016 0.7159 0.7159
Giardia lamblia Thymus-specific serine protease precursor 0.002 0.0005 0.001
Echinococcus granulosus transmembrane protease serine 3 0.0071 0.0126 0.0126
Trypanosoma brucei Aph-1 protein, putative 0.0099 0.0194 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0006 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0075 0.0075
Brugia malayi beta-lactamase 0.0037 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0006 0.0006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.002 0.0005 0.0005
Brugia malayi Cytochrome P450 family protein 0.0032 0.0034 0.0034
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0245 0.0542 0.0542
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0049 0.0049
Leishmania major centrin, putative,caltractin, putative 0.0179 0.0384 0.11
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0001 0.0001
Entamoeba histolytica grainin, putative 0.0181 0.0391 0.2088
Schistosoma mansoni hypothetical protein 0.0179 0.0384 0.0384
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0071 0.0071
Plasmodium vivax proteasome subunit beta type-2, putative 0.0039 0.005 0.0189
Echinococcus multilocularis enteropeptidase 0.0071 0.0126 0.0126
Onchocerca volvulus 0.0071 0.0126 0.0272
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Brugia malayi Kringle domain containing protein 0.0022 0.0011 0.0011
Trypanosoma brucei centrin, putative 0.0179 0.0384 0.11
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0039 0.005 0.005
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0149
Giardia lamblia Cathepsin B precursor 0.0245 0.0542 0.1561
Trichomonas vaginalis calmodulin, putative 0.0179 0.0384 0.1108
Echinococcus granulosus calpain 7 C02 family 0.1127 0.2649 0.2649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0049 0.0049
Giardia lamblia Serine peptidase, putative 0.002 0.0005 0.001
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Brugia malayi Papain family cysteine protease containing protein 0.0464 0.1065 0.1065
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.000000009827 0.000000009827
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Plasmodium vivax vivapain-3 0.0464 0.1065 0.402
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0245 0.0542 0.1564
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.0739 0.0739
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0496 0.1143 0.2551
Schistosoma mansoni survival motor neuron protein 0.0047 0.0071 0.0071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0049 0.0049
Trichomonas vaginalis calmodulin, putative 0.0179 0.0384 0.1108
Echinococcus multilocularis cathepsin L 0.0464 0.1065 0.1065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0006 0.0006
Schistosoma mansoni neuronal calcium sensor 0.0179 0.0384 0.0384
Leishmania major centrin, putative 0.0179 0.0384 0.11
Onchocerca volvulus 0.0785 0.1832 0.4094
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0049 0.0049
Schistosoma mansoni calpain-2 (C02 family) 0.0327 0.0739 0.0739
Loa Loa (eye worm) calpain family protein 1 0.2216 0.5249 0.5249
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.147 0.3467 0.9928
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0034 0.004 0.0115
Onchocerca volvulus Prolyl endopeptidase homolog 0.148 0.3493 0.7815
Brugia malayi fibroinase precursor 0.0245 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0136 0.0283 0.0283
Echinococcus multilocularis calbindin 32 0.0181 0.0391 0.0391
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0062 0.0107 0.0306
Trypanosoma brucei cysteine peptidase C (CPC) 0.147 0.3467 0.9928
Schistosoma mansoni nuclear hormone receptor 0.002 0.0006 0.0006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0049 0.0049
Brugia malayi prolyl oligopeptidase family protein 0.0496 0.1143 0.1143
Echinococcus multilocularis cysteine protease 0.0785 0.1832 0.1832
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0071 0.0071
Brugia malayi Papain family cysteine protease containing protein 0.0245 0.0542 0.0542
Giardia lamblia Cathepsin B precursor 0.0245 0.0542 0.1561
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0034 0.0034
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.018 0.0387 0.0387
Echinococcus multilocularis tumor protein p63 0.0334 0.0756 0.0756
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.0739 0.0739
Giardia lamblia Cysteine protease 0.0245 0.0542 0.1561
Loa Loa (eye worm) hypothetical protein 0.0245 0.0542 0.0542
Schistosoma mansoni hypothetical protein 0.0179 0.0384 0.0384
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.0785 0.1832 0.5245
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0605 0.1403 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0049
Brugia malayi hypothetical protein 0.0038 0.0049 0.0049
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0245 0.0542 0.2047
Brugia malayi Papain family cysteine protease containing protein 0.0785 0.1832 0.1832
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0001 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0245 0.0542 0.1564
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0245 0.0542 0.0542
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0327 0.0739 0.0739
Brugia malayi Trypsin family protein 0.0071 0.0126 0.0126
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.066 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0327 0.0739 0.2116
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0006 0.0006
Brugia malayi prolyl oligopeptidase family protein 0.0268 0.0598 0.0598
Trypanosoma cruzi cysteine peptidase, putative 0.0219 0.0481 0.0481
Giardia lamblia Cathepsin L precursor 0.0245 0.0542 0.1561
Echinococcus multilocularis calpain 7 (C02 family) 0.1127 0.2649 0.2649
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0245 0.0542 0.2047
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0384 0.1108
Schistosoma mansoni cathepsin C 0.0245 0.0542 0.0542
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Schistosoma mansoni hypothetical protein 0.0136 0.0283 0.0283
Entamoeba histolytica calmodulin, putative 0.0179 0.0384 0.2051
Toxoplasma gondii hypothetical protein 0.018 0.0387 0.1108
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0034 0.004 0.0115
Toxoplasma gondii ABC1 family protein 0.0037 0.0047 0.0135
Entamoeba histolytica protein kinase, putative 0.08 0.1868 1
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.051 0.051
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1127 0.2649 0.2649
Echinococcus granulosus prolyl endopeptidase 0.148 0.3493 0.3493
Brugia malayi Cathepsin L-like precursor 0.0566 0.1309 0.1309
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3194 0.7585 0.7585
Onchocerca volvulus Cathepsin L homolog 0.0785 0.1832 0.4094
Echinococcus granulosus cpg binding protein 0.0029 0.0028 0.0028
Echinococcus granulosus enteropeptidase 0.0071 0.0126 0.0126
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0179 0.0384 0.1108
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0049 0.0049
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0179 0.0386 0.0386
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0049 0.0049
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.2216 0.5249 0.5249
Trypanosoma cruzi oligopeptidase b 0.0605 0.1403 0.1403
Entamoeba histolytica hypothetical protein 0.0038 0.0049 0.0258
Entamoeba histolytica hypothetical protein 0.0038 0.0049 0.0258
Plasmodium vivax unspecified product 0.0245 0.0542 0.2047
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0245 0.0542 0.2047
Onchocerca volvulus 0.002 0.0006 0.0003
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0039 0.005 0.005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0464 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0219 0.0481 0.0481
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0005 0.0014
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0001 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0101 0.0101
Loa Loa (eye worm) calpain 5 0.08 0.1868 0.1868
Trichomonas vaginalis conserved hypothetical protein 0.0245 0.0542 0.1564
Leishmania major kinesin, putative 0.08 0.1868 0.535
Trichomonas vaginalis calmodulin, putative 0.0179 0.0384 0.1108
Loa Loa (eye worm) ctsf protein 0.0785 0.1832 0.1832
Brugia malayi Trypsin-like protease protein 5 0.0071 0.0126 0.0126
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0006 0.0006
Onchocerca volvulus 0.0071 0.0126 0.0272
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0047 0.0047
Loa Loa (eye worm) calmodulin-like protein 0.0179 0.0384 0.0384
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.005 0.005
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0062 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0006 0.0006
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0246 0.0246
Trypanosoma brucei I/6 autoantigen 0.0179 0.0384 0.11
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.015 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Schistosoma mansoni microtubule-associated protein tau 0.1394 0.3287 0.3287
Trypanosoma brucei oligopeptidase b 0.0605 0.1403 0.4017
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.0739 0.0739
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0062 0.0107 0.0308
Leishmania major calcineurin B subunit, putative 0.0179 0.0384 0.11
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0049 0.0049
Giardia lamblia Cysteine protease 0.0245 0.0542 0.1561
Onchocerca volvulus 0.0037 0.0047 0.0095
Plasmodium vivax calpain, putative 0.1127 0.2649 1
Plasmodium vivax unspecified product 0.0464 0.1065 0.402
Schistosoma mansoni cathepsin S (C01 family) 0.0245 0.0542 0.0542
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Brugia malayi cathepsin Z-like cysteine proteinase 0.0245 0.0542 0.0542
Trichomonas vaginalis calmodulin-2, putative 0.0179 0.0384 0.1108
Loa Loa (eye worm) hypothetical protein 0.0245 0.0542 0.0542
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0181 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0245 0.0542 0.0542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0245 0.0542 0.1564
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0047 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Echinococcus granulosus EF hand domain containing family member A2 0.0181 0.0391 0.0391
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0126
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0327 0.0739 0.0739
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0006 0.0006
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0268 0.0598 0.0598
Brugia malayi hypothetical protein 0.0136 0.0283 0.0283
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0071 0.0126 0.0126
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0001 0.0004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3194 0.7585 0.7585
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0062 0.0107 0.0583
Onchocerca volvulus 0.0785 0.1832 0.4094
Loa Loa (eye worm) hypothetical protein 0.0231 0.051 0.051
Schistosoma mansoni cpg binding protein 0.0029 0.0028 0.0028
Entamoeba histolytica prolyl oligopeptidase family protein 0.018 0.0387 0.2065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0245 0.0542 0.1561
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.147 0.3467 0.3467
Trichomonas vaginalis calmodulin, putative 0.0186 0.0402 0.1159
Leishmania major cathepsin L-like protease 0.0785 0.1832 0.5245
Brugia malayi EF hand family protein 0.0181 0.0391 0.0391
Plasmodium falciparum centrin-1 0.0179 0.0384 0.2097
Echinococcus multilocularis caspase 2 0.0154 0.0325 0.0325
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0313 0.0902
Loa Loa (eye worm) hypothetical protein 0.0566 0.1309 0.1309
Brugia malayi PXA domain containing protein 0.0038 0.0049 0.0049
Leishmania major calpain family cysteine protease-like protein 0.0327 0.0739 0.2116
Schistosoma mansoni ap endonuclease 0.0018 0.0001 0.0001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4205 1 1
Schistosoma mansoni calmodulin related calcium binding protein 0.0179 0.0384 0.0384
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0464 0.1065 0.1065
Giardia lamblia Cathepsin B precursor 0.147 0.3467 1
Echinococcus granulosus EF hand domain containing family member A2 0.0179 0.0384 0.0384
Loa Loa (eye worm) proteasome subunit beta type 1 0.0062 0.0107 0.0107
Schistosoma mansoni coup transcription factor 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.148 0.3493 0.3493
Entamoeba histolytica cysteine proteinase, putative 0.0464 0.1065 0.5698
Entamoeba histolytica dipeptidyl-peptidase, putative 0.018 0.0387 0.2065
Trypanosoma cruzi conserved protein 0.0327 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0245 0.0542 0.1564
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Trypanosoma cruzi calmodulin, putative 0.0179 0.0384 0.0384
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0107 0.0107
Entamoeba histolytica calpain family cysteine protease, putative 0.0327 0.0739 0.395
Trypanosoma brucei calmodulin, putative 0.0179 0.0384 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0143
Brugia malayi PXA domain containing protein 0.0038 0.0049 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0047 0.0326
Loa Loa (eye worm) hypothetical protein 0.1889 0.4468 0.4468
Plasmodium vivax hypothetical protein, conserved 0.018 0.0387 0.1461
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0006 0.0006
Brugia malayi steroid hormone receptor 0.002 0.0006 0.0006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Echinococcus multilocularis neuronal calcium sensor 0.0179 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0566 0.1309 0.1309
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0384 0.1108
Trypanosoma brucei calpain-like protein, putative 0.1127 0.2649 0.7586
Trichomonas vaginalis calmodulin, putative 0.0179 0.0384 0.1108
Trypanosoma brucei hypothetical protein 0.0327 0.0739 0.2116
Trichomonas vaginalis calcium binding protein, putative 0.0179 0.0384 0.1108
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0049 0.0049
Trypanosoma brucei calpain-like protein, putative 0.1127 0.2649 0.7586
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0327 0.0739 0.2116
Trypanosoma cruzi 20S proteasome subunit 0.0039 0.005 0.005
Schistosoma mansoni ap endonuclease 0.0018 0.0001 0.0001
Plasmodium falciparum peptidase, putative 0.018 0.0387 0.2112
Brugia malayi Cathepsin L-like cysteine proteinase 0.0566 0.1309 0.1309
Leishmania major hypothetical protein, conserved 0.0179 0.0384 0.11
Trypanosoma cruzi calmodulin, putative 0.0179 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0785 0.1832 0.1832
Entamoeba histolytica cysteine proteinase, putative 0.0464 0.1065 0.5698
Echinococcus multilocularis calpain 5 0.1127 0.2649 0.2649
Echinococcus multilocularis neurocalcin 0.0179 0.0384 0.0384
Leishmania major calmodulin, putative 0.0179 0.0384 0.11
Leishmania major proteasome beta 5 subunit, putative 0.008 0.015 0.0428
Trichomonas vaginalis calmodulin, putative 0.0179 0.0384 0.1108
Brugia malayi gamma-secretase subunit aph-1 0.0254 0.0563 0.0563
Entamoeba histolytica cysteine proteinase, putative 0.0464 0.1065 0.5698
Schistosoma mansoni hypothetical protein 0.0179 0.0386 0.0386
Entamoeba histolytica calcium-binding protein, putative 0.0179 0.0384 0.2051
Brugia malayi Trypsin family protein 0.0071 0.0126 0.0126
Schistosoma mansoni neuronal calcium sensor 0.0179 0.0384 0.0384
Echinococcus granulosus glycoprotein Antigen 5 0.0071 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0566 0.1309 0.3775
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0245 0.0542 0.1564
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0071 0.0071
Mycobacterium ulcerans hypothetical protein 0.0071 0.0126 0.0892
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0327 0.0739 0.0739
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0179 0.0384 0.11
Echinococcus multilocularis EF hand domain containing family member A2 0.0181 0.0391 0.0391
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0179 0.0384 0.2051
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0126
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.008 0.015 0.0794
Onchocerca volvulus 0.0472 0.1084 0.2419
Echinococcus multilocularis programmed cell death protein 0.0186 0.0402 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0006 0.0006
Echinococcus granulosus caspase 2 0.0154 0.0325 0.0325
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0179 0.0384 0.0384
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0136
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0062 0.0107 0.0107
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0101 0.0101
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0327 0.0739 0.0739
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0785 0.1832 1
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0049 0.0049
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0049 0.0049
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0179 0.0384 0.0384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Plasmodium falciparum serine repeat antigen 2 0.0245 0.0542 0.296
Plasmodium vivax vivapain-2 0.0785 0.1832 0.6915
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0245 0.0542 0.2897
Echinococcus multilocularis programmed cell death protein 0.0186 0.0402 0.0402
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.0739 0.0739
Brugia malayi MH2 domain containing protein 0.0144 0.0302 0.0302
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1127 0.2649 0.2649
Toxoplasma gondii calcium-dependent protein kinase 0.0181 0.0391 0.112
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0047 0.0149
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.018 0.0387 0.1108
Leishmania major programmed cell death 6 protein-like protein 0.0179 0.0384 0.11
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0034 0.004 0.004
Trypanosoma brucei calpain-like protein, putative 0.1127 0.2649 0.7586
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1127 0.2649 0.2649
Brugia malayi CXXC zinc finger family protein 0.0028 0.0024 0.0024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0006 0.0006
Brugia malayi Peptidase C13 family protein 0.0149 0.0313 0.0313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.183 0.4329 0.4329
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0245 0.0542 0.0542
Toxoplasma gondii proteasome subunit beta type, putative 0.008 0.015 0.0428
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0049 0.0049
Schistosoma mansoni mitochondrial solute carrier 0.0179 0.0384 0.0384
Echinococcus granulosus neuronal calcium sensor 0.0179 0.0384 0.0384
Echinococcus granulosus calpain 5 0.1127 0.2649 0.2649
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0268 0.0598 0.0598
Trypanosoma cruzi I/6 autoantigen, putative 0.0179 0.0384 0.0384
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0219 0.0481 0.0481
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0071 0.0126 0.0126
Plasmodium vivax GPI-anchor transamidase, putative 0.0034 0.004 0.0152
Entamoeba histolytica cysteine protease, putative 0.0245 0.0542 0.2897
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0047 0.0047
Schistosoma mansoni ef hand domain family member A2 0.0179 0.0384 0.0384
Trypanosoma cruzi cruzipain precursor, putative 0.0219 0.0481 0.0481
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Onchocerca volvulus 0.0071 0.0126 0.0272
Brugia malayi Cathepsin L-like precursor 0.0785 0.1832 0.1832
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0049
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0071 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0049 0.0049
Onchocerca volvulus 0.0181 0.0391 0.0866
Trypanosoma brucei calpain, putative 0.0327 0.0739 0.2116
Leishmania major cysteine peptidase A (CPA) 0.0785 0.1832 0.5245
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0327 0.0739 0.2131
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4205 1 1
Giardia lamblia Cathepsin L-like protease 0.0245 0.0542 0.1561
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0785 0.1832 0.1832
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0006 0.0006
Trichomonas vaginalis calcium binding protein, putative 0.0179 0.0384 0.1108
Entamoeba histolytica calcium binding family protein 0.0179 0.0384 0.2051
Onchocerca volvulus Cathepsin F homolog 0.0785 0.1832 0.4094
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Plasmodium falciparum cysteine proteinase falcipain 1 0.0464 0.1065 0.5814
Echinococcus multilocularis cathepsin L cysteine protease 0.0785 0.1832 0.1832
Echinococcus granulosus inhibitor of apoptosis protein 0.0179 0.0386 0.0386
Echinococcus multilocularis glycoprotein Antigen 5 0.0071 0.0126 0.0126
Onchocerca volvulus 0.0179 0.0384 0.085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0245 0.0542 0.2897
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0245 0.0542 0.2047
Entamoeba histolytica hypothetical protein, conserved 0.018 0.0387 0.2065
Trichomonas vaginalis calcineurin B subunit, putative 0.0179 0.0384 0.1108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.7586
Trypanosoma cruzi centrin, putative 0.0186 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Loa Loa (eye worm) calpain D 0.0327 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0245 0.0542 0.1564
Onchocerca volvulus 0.0785 0.1832 0.4094
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0313 0.0902
Echinococcus multilocularis expressed protein 0.0746 0.174 0.174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Plasmodium vivax vivapain-2 0.0785 0.1832 0.6915
Brugia malayi calpain family protein 1 0.3016 0.7159 0.7159
Loa Loa (eye worm) hypothetical protein 0.0179 0.0384 0.0384
Brugia malayi ecdysteroid receptor 0.002 0.0006 0.0006
Onchocerca volvulus Legumain homolog 0.0149 0.0313 0.069
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0006 0.0006
Trichomonas vaginalis calmodulin, putative 0.0181 0.0391 0.1128
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0365 0.083 0.083
Loa Loa (eye worm) cathepsin B 0.147 0.3467 0.3467
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.0739 0.0739
Trypanosoma cruzi I/6 autoantigen, putative 0.0179 0.0384 0.0384
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0006 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0006 0.0006
Echinococcus granulosus GPI anchor transamidase 0.0034 0.004 0.004
Onchocerca volvulus Cathepsin L homolog 0.0785 0.1832 0.4094
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.7586
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0313 0.0902
Toxoplasma gondii calmodulin CAM1 0.0181 0.0391 0.112
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0149
Brugia malayi Protein kinase domain containing protein 0.0022 0.0011 0.0011
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0245 0.0542 0.1564
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0071 0.0126 0.0126
Mycobacterium ulcerans lipase LipD 0.0037 0.0047 0.0326
Giardia lamblia Alanyl dipeptidyl peptidase 0.018 0.0387 0.1113
Giardia lamblia GPI-anchor transamidase, putative 0.0034 0.004 0.0112
Giardia lamblia Cathepsin B precursor 0.147 0.3467 1
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0034 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0245 0.0542 0.2047
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0047 0.0047
Onchocerca volvulus 0.0071 0.0126 0.0272
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.002 0.0005 0.0014
Plasmodium falciparum serine repeat antigen 6 0.0245 0.0542 0.296
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Loa Loa (eye worm) cysteine protease 0.0785 0.1832 0.1832
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.002 0.0005 0.0005
Trichomonas vaginalis calcineurin B subunit, putative 0.0181 0.0391 0.1128
Schistosoma mansoni hypothetical protein 0.0071 0.0126 0.0126
Brugia malayi cathepsin L precursor 0.0245 0.0542 0.0542
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0006 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0006 0.0006
Echinococcus granulosus neurocalcin 0.0179 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0049 0.0049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0006 0.0006
Echinococcus multilocularis calpain 0.1127 0.2649 0.2649
Onchocerca volvulus Cathepsin L homolog 0.0245 0.0542 0.1204
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Leishmania major cathepsin L-like protease 0.0785 0.1832 0.5245
Echinococcus multilocularis prolyl endopeptidase 0.148 0.3493 0.3493
Brugia malayi cathepsin Z-like cysteine proteinase 0.0245 0.0542 0.0542
Onchocerca volvulus 0.0136 0.0283 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0245 0.0542 0.1564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0062 0.0107 0.0306
Echinococcus multilocularis calcium uptake protein 1 0.0181 0.0391 0.0391
Echinococcus multilocularis centrin 2 0.0179 0.0384 0.0384
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Toxoplasma gondii centrin 0.0179 0.0384 0.11
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0246 0.1747
Echinococcus multilocularis calmodulin 0.0179 0.0384 0.0384
Schistosoma mansoni hypothetical protein 0.0071 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0049
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0785 0.1832 0.1832
Echinococcus granulosus cathepsin L cysteine proteinase 0.0785 0.1832 0.1832
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0083 0.0083
Trypanosoma cruzi centrin-3 0.0186 0.0402 0.0402
Leishmania major cathepsin L-like protease 0.0785 0.1832 0.5245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Brugia malayi cathepsin L-like precursor 0.0566 0.1309 0.1309
Onchocerca volvulus Deterin homolog 0.0179 0.0386 0.0854
Loa Loa (eye worm) hypothetical protein 0.0245 0.0542 0.0542
Echinococcus multilocularis cathepsin b 0.4205 1 1
Entamoeba histolytica cysteine protease, putative 0.0245 0.0542 0.2897
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0071 0.0071
Brugia malayi Angiotensin-converting enzyme family protein 0.183 0.4329 0.4329
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1301 0.3064 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0071 0.0071
Trypanosoma brucei antigen, putative 0.1127 0.2649 0.7586
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Onchocerca volvulus 0.006 0.0101 0.0216
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.018 0.0387 0.1116
Schistosoma mansoni thyroid hormone receptor 0.002 0.0006 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0245 0.0542 0.0542
Plasmodium vivax SET domain protein, putative 0.006 0.0101 0.0382
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.148 0.3493 0.3493
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0327 0.0739 0.2131
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0049
Trichomonas vaginalis myosin light chain 1, putative 0.0179 0.0384 0.1108
Brugia malayi calcium-binding protein 0.0179 0.0384 0.0384
Entamoeba histolytica cysteine protease, putative 0.0785 0.1832 0.9805
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0149 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0114 0.023 0.023
Toxoplasma gondii preprocathepsin c precursor, putative 0.0245 0.0542 0.1553
Echinococcus granulosus cathepsin l1 0.0785 0.1832 0.1832
Toxoplasma gondii EFHC1, putative 0.0179 0.0384 0.11
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0039 0.005 0.0144
Brugia malayi Cathepsin L-like precursor 0.0566 0.1309 0.1309
Echinococcus multilocularis calpain A 0.3197 0.7592 0.7592
Trypanosoma cruzi cysteine peptidase, putative 0.0879 0.2057 0.2057
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.0527 0.1718
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0049 0.0049
Trichomonas vaginalis calmodulin, putative 0.0179 0.0384 0.1108
Entamoeba histolytica cysteine protease, putative 0.0245 0.0542 0.2897
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0047 0.0136
Echinococcus multilocularis apoptotic protease activating factor 1 0.0136 0.0283 0.0283
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0179 0.0384 0.0384
Schistosoma mansoni centrin 0.0179 0.0384 0.0384
Toxoplasma gondii troponin c, isotype gamma, putative 0.0179 0.0384 0.11
Echinococcus granulosus FTZ F1 alpha 0.002 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Trypanosoma brucei Component of motile flagella 41 0.0179 0.0384 0.11
Onchocerca volvulus 0.0037 0.0047 0.0095
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0149
Trichomonas vaginalis calcium binding protein, putative 0.0179 0.0384 0.1108
Loa Loa (eye worm) hypothetical protein 0.0154 0.0325 0.0325
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0179 0.0384 0.0384
Toxoplasma gondii cathepsin CPL 0.0785 0.1832 0.5245
Toxoplasma gondii prolyl endopeptidase 0.148 0.3493 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1127 0.2649 0.7586
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0047 0.0178
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0034 0.0096
Echinococcus multilocularis gamma secretase subunit aph 1 0.0254 0.0563 0.0563
Echinococcus multilocularis cathepsin L 0.0245 0.0542 0.0542
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0071 0.0126 0.0126
Giardia lamblia Cathepsin L precursor 0.0245 0.0542 0.1561
Leishmania major calmodulin-like protein 0.0179 0.0384 0.11
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0143
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0006 0.0006
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0107 0.0107
Echinococcus multilocularis cathepsin b 0.4205 1 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0245 0.0542 0.2047
Brugia malayi nuclear hormone receptor 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0075
Trypanosoma brucei prolyl endopeptidase 0.148 0.3493 1
Echinococcus multilocularis calumenin 0.0181 0.0391 0.0391
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.051 0.051
Onchocerca volvulus 0.0022 0.0011 0.0013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0034 0.023
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0327 0.0739 0.2131
Mycobacterium tuberculosis Probable peptidase 0.0605 0.1403 0.4577
Echinococcus granulosus calpain A 0.3197 0.7592 0.7592
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0327 0.0739 0.2131
Schistosoma mansoni cathepsin s 0.0219 0.0481 0.0481
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0049 0.0049
Trichomonas vaginalis calpain, putative 0.0327 0.0739 0.2131
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.148 0.3493 0.3493
Echinococcus granulosus microtubule associated protein 2 0.1394 0.3287 0.3287
Brugia malayi hypothetical protein 0.0149 0.0315 0.0315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0034 0.004 0.0116
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0179 0.0384 0.1108
Entamoeba histolytica calmodulin, putative 0.0179 0.0384 0.2051
Entamoeba histolytica hypothetical protein, conserved 0.0181 0.0391 0.2088
Entamoeba histolytica GPI-anchor transamidase, putative 0.0034 0.004 0.0209
Schistosoma mansoni inhibitor of apoptosis protein 0.0179 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0179 0.0386 0.0386
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0245 0.0542 0.2047
Leishmania major hypothetical protein, unknown function 0.0327 0.0739 0.2116
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0049 0.0049
Brugia malayi Cathepsin L-like precursor 0.0785 0.1832 0.1832
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0496 0.1143 0.1143
Trichomonas vaginalis calmodulin, putative 0.0179 0.0384 0.1108
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0785 0.1832 0.1832
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0047 0.0149
Toxoplasma gondii EF hand domain-containing protein 0.0179 0.0384 0.11
Brugia malayi hypothetical protein 0.0038 0.0049 0.0049
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0047 0.0149
Trypanosoma cruzi oligopeptidase b 0.0605 0.1403 0.1403
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Echinococcus granulosus cysteine protease 0.0464 0.1065 0.1065
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0246 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0011 0.0011
Plasmodium vivax centrin-1, putative 0.0179 0.0384 0.145
Schistosoma mansoni hypothetical protein 0.0047 0.0071 0.0071
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0039 0.005 0.0144
Echinococcus granulosus gamma secretase subunit aph 1 0.0254 0.0563 0.0563
Trypanosoma brucei hypothetical protein, conserved 0.0179 0.0384 0.11
Giardia lamblia Proteasome subunit beta type 1 0.0062 0.0107 0.0304
Onchocerca volvulus 0.0785 0.1832 0.4094
Entamoeba histolytica dipeptidyl-peptidase, putative 0.018 0.0387 0.2065
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0047 0.0149
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0605 0.1403 1
Onchocerca volvulus 0.0785 0.1832 0.4094
Plasmodium falciparum calpain 0.0327 0.0739 0.4033
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.015 0.015
Echinococcus granulosus expressed protein 0.0746 0.174 0.174
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.005 0.005
Schistosoma mansoni calpain (C02 family) 0.1127 0.2649 0.2649
Trypanosoma cruzi cysteine proteinase, putative 0.0464 0.1065 0.1065
Giardia lamblia Cathepsin L precursor 0.0245 0.0542 0.1561
Brugia malayi Cathepsin L-like precursor 0.0785 0.1832 0.1832
Trypanosoma brucei calmodulin, putative 0.0181 0.0391 0.112
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.147 0.3467 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0302 0.0302
Brugia malayi EF hand family protein 0.0179 0.0384 0.0384
Schistosoma mansoni memapsin-2 (A01 family) 0.0417 0.0953 0.0953
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0005 0.0019
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0246 0.0705
Trypanosoma brucei mitochondrial calcium uptake 1 0.0179 0.0384 0.11
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0049 0.0143
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0245 0.0542 0.296
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0047 0.0135
Loa Loa (eye worm) fibroinase 0.0785 0.1832 0.1832
Trypanosoma brucei kinesin, putative 0.08 0.1868 0.535
Toxoplasma gondii serine carboxypeptidase s28 protein 0.002 0.0005 0.0014
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Trypanosoma cruzi caltractin, putative 0.0179 0.0384 0.0384
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1127 0.2649 0.2649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0006 0.0006
Giardia lamblia Cysteine protease 0.0245 0.0542 0.1561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Entamoeba histolytica grainin 2 0.0186 0.0402 0.2145
Brugia malayi proteasome subunit beta type 2 0.0039 0.005 0.005
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0049 0.0049
Schistosoma mansoni rab 0.0179 0.0384 0.0384
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0327 0.0739 0.2116
Trichomonas vaginalis conserved hypothetical protein 0.0327 0.0739 0.2131
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0365 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Trypanosoma cruzi cysteine proteinase, putative 0.0464 0.1065 0.1065
Trypanosoma brucei calpain-like protein, putative 0.1127 0.2649 0.7586
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0245 0.0542 0.0542
Brugia malayi prolyl oligopeptidase family protein 0.018 0.0387 0.0387
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0062 0.0107 0.0565
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0254 0.0563 0.0563
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Schistosoma mansoni hemoglobinase (C13 family) 0.0149 0.0313 0.0313
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0071 0.0071
Giardia lamblia Cathepsin B precursor 0.147 0.3467 1
Mycobacterium ulcerans proteasome PrcB 0.008 0.015 0.1057
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Loa Loa (eye worm) hypothetical protein 0.0566 0.1309 0.1309
Brugia malayi proteasome subunit beta type 1 0.0062 0.0107 0.0107
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.2649
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0126
Entamoeba histolytica cysteine proteinase, putative 0.0464 0.1065 0.5698
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4205 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0245 0.0542 0.0542
Toxoplasma gondii centrin, putative 0.0179 0.0384 0.11
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0126
Giardia lamblia Cathepsin L precursor 0.0245 0.0542 0.1561
Schistosoma mansoni cpg binding protein 0.0029 0.0028 0.0028
Echinococcus multilocularis calpain family protein 1, d 0.2216 0.5249 0.5249
Giardia lamblia Proteasome subunit beta type 5 precursor 0.008 0.015 0.0428
Echinococcus granulosus cathepsin l cysteine peptidase 0.0785 0.1832 0.1832
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0101 0.0289
Giardia lamblia Hypothetical protein 0.0245 0.0542 0.1561
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0034 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0104 0.0104
Leishmania major hypothetical protein, conserved 0.0037 0.0047 0.0135
Brugia malayi programmed cell death protein 6 0.0179 0.0384 0.0384
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0006 0.0006
Plasmodium falciparum serine repeat antigen 1 0.0245 0.0542 0.296
Plasmodium vivax proteasome subunit beta type-1, putative 0.0062 0.0107 0.0403
Schistosoma mansoni cathepsin B (C01 family) 0.0245 0.0542 0.0542
Plasmodium falciparum proteasome subunit beta type-5 0.008 0.015 0.0816
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0246 0.0246
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Schistosoma mansoni calpain C (C02 family) 0.1127 0.2649 0.2649
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.018 0.0387 0.0387
Echinococcus granulosus apoptotic protease activating factor 1 0.0136 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0785 0.1832 0.5283
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0039 0.005 0.005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0047 0.0149
Brugia malayi hypothetical protein 0.0088 0.0169 0.0169
Echinococcus multilocularis microtubule associated protein 2 0.1394 0.3287 0.3287
Schistosoma mansoni cpg binding protein 0.0028 0.0024 0.0024
Brugia malayi prolyl oligopeptidase family protein 0.018 0.0387 0.0387
Onchocerca volvulus 0.0047 0.0071 0.0147
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.018 0.0387 0.1116
Brugia malayi Cathepsin L-like precursor 0.0785 0.1832 0.1832
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0039 0.005 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0006 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4205 1 1
Schistosoma mansoni reticulocalbin 0.0179 0.0384 0.0384
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0179 0.0386 0.0386
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0049 0.0049
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0126
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0094 0.0094
Onchocerca volvulus 0.0785 0.1832 0.4094
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0034 0.0034
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0049 0.0049
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0179 0.0384 0.0384
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0496 0.1143 0.1143
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0219 0.0481 0.0481
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0245 0.0542 0.2047
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0268 0.0598 0.0598
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0605 0.1403 0.4017
Brugia malayi Cathepsin L-like precursor 0.0785 0.1832 0.1832
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0071 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0219 0.0481 0.0481
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0136
Brugia malayi beta-lactamase family protein 0.0037 0.0047 0.0047
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Entamoeba histolytica hypothetical protein 0.0038 0.0049 0.0258
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0179 0.0386 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0006 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0101 0.0101
Leishmania major oligopeptidase b 0.0605 0.1403 0.4017
Loa Loa (eye worm) hypothetical protein 0.0179 0.0386 0.0386
Schistosoma mansoni calmodulin 0.0179 0.0384 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0088 0.0169 0.0169
Toxoplasma gondii hypothetical protein 0.0327 0.0739 0.2116
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.7586
Echinococcus multilocularis caspase 8 0.0018 0.000000009827 0.000000009827
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Trypanosoma brucei proteasome beta 6 subunit 0.0062 0.0107 0.0306
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0006 0.0006
Trypanosoma cruzi major cysteine proteinase, putative 0.0245 0.0542 0.0542
Schistosoma mansoni reticulocalbin 0.0181 0.0391 0.0391
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Toxoplasma gondii peptidase c13 family protein 0.0034 0.004 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0245 0.0542 0.1564
Toxoplasma gondii cathepsin CPC2 0.0245 0.0542 0.1553
Trypanosoma brucei protein I/6 0.0179 0.0384 0.11
Onchocerca volvulus 0.0071 0.0126 0.0272
Entamoeba histolytica calpain large subunit domain III containing protein 0.08 0.1868 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0071 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0245 0.0542 0.1564
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Leishmania major hypothetical protein, conserved 0.0181 0.0391 0.112
Schistosoma mansoni cathepsin F (C01 family) 0.0785 0.1832 0.1832
Leishmania major calmodulin-like protein 0.0179 0.0384 0.11
Echinococcus granulosus Mastin 0.0071 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Trypanosoma brucei cysteine peptidase, putative 0.0327 0.0739 0.2116
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0005 0.0005
Plasmodium falciparum serine repeat antigen 9 0.0245 0.0542 0.296
Trichomonas vaginalis set domain proteins, putative 0.0471 0.1084 0.3126
Brugia malayi Trypsin family protein 0.0071 0.0126 0.0126
Echinococcus granulosus calbindin 32 0.0181 0.0391 0.0391
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0047 0.0149
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0049 0.0049
Trichomonas vaginalis calpain, putative 0.0327 0.0739 0.2131
Plasmodium falciparum serine repeat antigen 7 0.0245 0.0542 0.296
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.0902 0.0902
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0011 0.0011
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0313 0.0902
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0047 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0001 0.0001
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0268 0.0598 0.0598
Brugia malayi calpain D 0.0327 0.0739 0.0739
Toxoplasma gondii cathepsin CPC1 0.0245 0.0542 0.1553
Echinococcus multilocularis cathepsin L cysteine protease 0.0785 0.1832 0.1832
Echinococcus granulosus cathepsin L cysteine protease 0.0464 0.1065 0.1065
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0245 0.0542 0.0542
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0001 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Mycobacterium leprae proteasome (beta subunit) PrcB 0.008 0.015 0.0756
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0313 0.0902
Loa Loa (eye worm) prolyl oligopeptidase 0.018 0.0387 0.0387
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0006 0.0003
Echinococcus granulosus calpain 0.1127 0.2649 0.2649
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.008 0.015 0.015
Loa Loa (eye worm) calpain family protein 1 0.3016 0.7159 0.7159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.0785 0.1832 0.5245
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0246 0.1747
Trypanosoma cruzi cysteine peptidase, putative 0.0879 0.2057 0.2057
Brugia malayi cathepsin F-like cysteine proteinase 0.0219 0.0481 0.0481
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.0387 0.0387
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0268 0.0598 0.1712
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0179 0.0386 0.0386
Onchocerca volvulus 0.0028 0.0024 0.0043
Trichomonas vaginalis centrin, putative 0.0179 0.0384 0.1108
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0049 0.0049
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0605 0.1403 0.4577
Echinococcus granulosus EF HAND 1 calcium binding site 0.0179 0.0384 0.0384
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0047 0.0149
Leishmania major cathepsin L-like protease 0.0879 0.2057 0.5888
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.2649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0785 0.1832 0.5283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0464 0.1065 0.3072
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0071 0.0071
Onchocerca volvulus 0.0179 0.0386 0.0854
Schistosoma mansoni hypothetical protein 0.0395 0.0902 0.0902
Entamoeba histolytica prolyl oligopeptidase family protein 0.018 0.0387 0.2065
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0179 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0071 0.0126 0.0126
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0001 0.0007
Echinococcus multilocularis EF hand domain containing family member A2 0.0179 0.0384 0.0384
Echinococcus multilocularis hypothetical protein 0.1127 0.2649 0.2649
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0245 0.0542 0.1561
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.008 0.015 0.0484
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0245 0.0542 0.0542
Brugia malayi Cell death protein 3 precursor 0.0154 0.0325 0.0325
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0245 0.0542 0.1561
Echinococcus granulosus tumor protein p63 0.0334 0.0756 0.0756
Trypanosoma brucei Calpain-like protein CALP1.3 0.0327 0.0739 0.2116
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0245 0.0542 0.0542
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0089 0.0254
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0245 0.0542 0.0542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 0.2057 0.5888
Schistosoma mansoni gamma-secretase subunit aph-1 0.0254 0.0563 0.0563
Loa Loa (eye worm) trypsin family protein 0.0071 0.0126 0.0126
Brugia malayi Serine carboxypeptidase S28 family protein 0.002 0.0005 0.0005
Echinococcus granulosus cathepsin b 0.4205 1 1
Leishmania major cathepsin L-like protease 0.0879 0.2057 0.5888
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0313 0.0902
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0006 0.0006
Toxoplasma gondii cathepsin B 0.147 0.3467 0.9928
Brugia malayi hypothetical protein 0.0231 0.051 0.051
Toxoplasma gondii exonuclease III APE 0.0018 0.0001 0.0004
Leishmania major hypothetical protein, conserved 0.0327 0.0739 0.2116
Entamoeba histolytica cysteine proteinase, putative 0.0785 0.1832 0.9805
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0049 0.0049
Echinococcus multilocularis proteasome (prosome, macropain) 0.008 0.015 0.015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1127 0.2649 0.2649
Trypanosoma brucei caltractin, putative 0.0186 0.0402 0.115
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0011 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.0464 0.1065 0.1065
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0005 0.0019
Leishmania major calpain protease-like protein 0.0327 0.0739 0.2116
Trypanosoma cruzi calmodulin, putative 0.0179 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.2689 0.6378 0.6378
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0049 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.0387 0.0387
Entamoeba histolytica cysteine protease, putative 0.0464 0.1065 0.5698
Leishmania major calmodulin, putative 0.0179 0.0384 0.11
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0246 0.0705
Schistosoma mansoni neuronal calcium sensor 0.0179 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.018 0.0387 0.0387
Giardia lamblia Alanyl dipeptidyl peptidase 0.018 0.0387 0.1113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0071 0.0126 0.0126
Echinococcus multilocularis transmembrane protease serine 3 0.0071 0.0126 0.0126
Brugia malayi Papain family cysteine protease containing protein 0.0464 0.1065 0.1065
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0005 0.0014
Echinococcus granulosus calmodulin 0.0179 0.0384 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.2116
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0327 0.0739 0.2116
Plasmodium falciparum cysteine proteinase falcipain 3 0.0785 0.1832 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) beta-lactamase 0.0037 0.0047 0.0047
Entamoeba histolytica cysteine proteinase 1, putative 0.0464 0.1065 0.5698
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0327 0.0739 0.2131
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.008 0.015 0.0431
Echinococcus granulosus cathepsin L 0.0245 0.0542 0.0542
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0181 0.0391 0.0391
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0049 0.0049
Onchocerca volvulus 0.0149 0.0315 0.0695
Brugia malayi hypothetical protein 0.0071 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0101
Schistosoma mansoni cercarial elastase (S01 family) 0.0071 0.0126 0.0126
Giardia lamblia Hypothetical protein 0.0245 0.0542 0.1561
Plasmodium vivax serine-repeat antigen (SERA) 0.0245 0.0542 0.2047
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0006 0.0006
Echinococcus multilocularis cysteine protease 0.0785 0.1832 0.1832
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0049 0.0049
Trypanosoma cruzi centrin, putative 0.0186 0.0402 0.0402
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0101 0.0101
Plasmodium falciparum serine repeat antigen 8 0.0245 0.0542 0.296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0566 0.1309 0.3775
Brugia malayi Pre-SET motif family protein 0.006 0.0101 0.0101
Trypanosoma cruzi prolyl endopeptidase 0.148 0.3493 0.3493
Leishmania major cytochrome p450-like protein 0.0032 0.0034 0.0096
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0024 0.0024
Leishmania major centrin, putative 0.0179 0.0384 0.11
Trypanosoma cruzi Aph-1 protein, putative 0.0099 0.0194 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.018 0.0387 0.0387
Leishmania major hypothetical protein, conserved 0.0022 0.0011 0.003
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0313 0.0902
Echinococcus granulosus calpain A 0.1127 0.2649 0.2649
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0179 0.0384 0.0384
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0327 0.0739 0.0739
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0047 0.0047
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0245 0.0542 0.2897
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3194 0.7585 0.7585
Giardia lamblia Hypothetical protein 0.0181 0.0391 0.1125
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0785 0.1832 0.5283
Echinococcus granulosus calumenin 0.0181 0.0391 0.0391

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.