Detailed information for compound 1446441

Basic information

Technical information
  • TDR Targets ID: 1446441
  • Name: [2-oxo-2-(2-oxoimidazolidin-1-yl)ethyl] 3-chl oro-4,5-dimethoxybenzoate
  • MW: 342.732 | Formula: C14H15ClN2O6
  • H donors: 1 H acceptors: 3 LogP: 1.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(Cl)cc(cc1OC)C(=O)OCC(=O)N1CCNC1=O
  • InChi: 1S/C14H15ClN2O6/c1-21-10-6-8(5-9(15)12(10)22-2)13(19)23-7-11(18)17-4-3-16-14(17)20/h5-6H,3-4,7H2,1-2H3,(H,16,20)
  • InChiKey: ZFSWYFMPNPJLTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-oxo-2-(2-oxoimidazolidin-1-yl)ethyl] 3-chloro-4,5-dimethoxy-benzoate
  • 3-chloro-4,5-dimethoxybenzoic acid [2-oxo-2-(2-oxo-1-imidazolidinyl)ethyl] ester
  • 3-chloro-4,5-dimethoxy-benzoic acid [2-keto-2-(2-ketoimidazolidin-1-yl)ethyl] ester
  • ZINC08344703
  • T5551882

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis proteasome (prosome, macropain) 0.0084 0.0413 0.0409
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2394 0.2365
Onchocerca volvulus 0.004 0.0128 0.0124
Onchocerca volvulus 0.004 0.0128 0.0124
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0059 0.0255 0.0255
Brugia malayi cathepsin F-like cysteine proteinase 0.0196 0.113 0.113
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0048 0.018 0.0071
Leishmania major cytochrome p450-like protein 0.0048 0.018 0.0165
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0238 0.1405 0.1401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0084 0.0413 0.0684
Leishmania major cathepsin L-like protease 0.0715 0.4467 0.4459
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0084 0.0413 0.0409
Brugia malayi gamma-secretase subunit aph-1 0.0238 0.1405 0.1405
Loa Loa (eye worm) hypothetical protein 0.0139 0.0764 0.076
Brugia malayi prolyl oligopeptidase family protein 0.0177 0.1013 0.1013
Onchocerca volvulus 0.0153 0.0856 0.0853
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0171 0.0167
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0631 0.0617
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Trypanosoma brucei calpain, putative 0.0118 0.0631 0.0596
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0221 0.1293 0.1289
Loa Loa (eye worm) calmodulin-like protein 0.0057 0.0238 0.0235
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 0.202 0.4507
Loa Loa (eye worm) hypothetical protein 0.104 0.6554 0.6553
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0118 0.0266
Leishmania major hypothetical protein, unknown function 0.0118 0.0631 0.0617
Brugia malayi Trypsin family protein 0.004 0.0128 0.0128
Loa Loa (eye worm) cytochrome P450 0.0048 0.018 0.0176
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.109 0.6873 0.6872
Plasmodium falciparum cysteine proteinase falcipain 1 0.0334 0.202 0.5211
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0659 0.0644
Brugia malayi programmed cell death protein 6 0.0057 0.0238 0.0238
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0057 0.0238 0.0524
Onchocerca volvulus 0.004 0.0128 0.0124
Giardia lamblia Hypothetical protein 0.0057 0.0243 0.0783
Schistosoma mansoni axis inhibition protein axin 0.0038 0.012 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0048 0.018 0.0071
Echinococcus granulosus calpain 7 C02 family 0.0392 0.2394 0.2391
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0764 0.076
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0427 0.0423
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Echinococcus granulosus glycogen phosphorylase 0.011 0.0579 0.0575
Echinococcus granulosus acylamino acid releasing enzyme 0.0177 0.1013 0.101
Loa Loa (eye worm) hypothetical protein 0.0057 0.0238 0.0235
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0153 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0139 0.0764 0.1945
Echinococcus multilocularis neuronal calcium sensor 0.0057 0.0238 0.0235
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0177 0.1013 0.0999
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0059 0.0255 0.083
Leishmania major cytochrome p450-like protein 0.009 0.045 0.0436
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0016 0.0012
Entamoeba histolytica calpain family cysteine protease, putative 0.0118 0.0631 0.1551
Schistosoma mansoni Mername-AA248 (C02 family) 0.0392 0.2394 0.2391
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0095 0.013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0293 0.0579
Brugia malayi Cathepsin L-like precursor 0.0425 0.2606 0.2606
Entamoeba histolytica cysteine proteinase 1, putative 0.0334 0.202 0.5183
Leishmania major cathepsin L-like protease 0.0621 0.3862 0.3852
Trypanosoma brucei calpain, putative 0.0118 0.0631 0.0596
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0118 0.0631 0.1349
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0243 0.0591
Plasmodium falciparum proteasome subunit beta type-5 0.0084 0.0413 0.1033
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0057 0.0238 0.0235
Brugia malayi Cell death protein 3 precursor 0.003 0.0067 0.0067
Brugia malayi Cytochrome P450 family protein 0.009 0.045 0.045
Brugia malayi Proteasome A-type and B-type family protein 0.0084 0.0413 0.0413
Entamoeba histolytica cysteine proteinase, putative 0.0334 0.202 0.5183
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0069 0.014
Trypanosoma brucei cytochrome P450, putative 0.009 0.045 0.0414
Brugia malayi cathepsin F-like cysteine proteinase 0.0139 0.0764 0.0764
Trypanosoma cruzi centrin, putative 0.0057 0.0238 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Onchocerca volvulus 0.0621 0.3862 0.386
Trypanosoma cruzi caltractin, putative 0.0057 0.0238 0.0223
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0118 0.0631 0.0617
Loa Loa (eye worm) programmed cell death protein 6 0.0057 0.0243 0.0239
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0177 0.1013 0.101
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.012 0.0117
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2382
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.004 0.0133 0.0118
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0118 0.0181
Leishmania major calmodulin-like protein 0.0057 0.0238 0.0223
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0631 0.0617
Onchocerca volvulus 0.004 0.0128 0.0124
Trichomonas vaginalis calcium binding protein, putative 0.0057 0.0238 0.0456
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0048 0.018 0.0165
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0065 0.0293 0.0277
Giardia lamblia Cathepsin L precursor 0.0139 0.0764 0.2775
Trypanosoma brucei hypothetical protein 0.0118 0.0631 0.0596
Echinococcus granulosus proteasome prosome macropain 0.0084 0.0413 0.0409
Brugia malayi Animal haem peroxidase family protein 0.013 0.0708 0.0708
Schistosoma mansoni calmodulin 0.0057 0.0238 0.0235
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0764 0.076
Echinococcus multilocularis 0.0048 0.018 0.0176
Echinococcus granulosus cathepsin L 0.0334 0.202 0.2017
Leishmania major oligopeptidase b 0.0635 0.3953 0.3943
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0764 0.165
Toxoplasma gondii proteasome subunit beta type 2, putative 0.004 0.0133 0.0118
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0118 0.0114
Onchocerca volvulus 0.013 0.0708 0.0705
Echinococcus granulosus cysteine protease 0.0334 0.202 0.2017
Brugia malayi Cytochrome P450 family protein 0.0048 0.018 0.018
Giardia lamblia Cathepsin L precursor 0.0139 0.0764 0.2775
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0764 0.076
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0047 0.0179 0.007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0171 0.0171
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.012 0.0117
Brugia malayi Cathepsin L-like cysteine proteinase 0.0425 0.2606 0.2606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Toxoplasma gondii proteasome subunit beta type, putative 0.0084 0.0413 0.0398
Brugia malayi hypothetical protein 0.013 0.0708 0.0708
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0004 0.0004
Schistosoma mansoni centrin-related 0.0057 0.0238 0.0235
Echinococcus multilocularis neurocalcin 0.0057 0.0238 0.0235
Echinococcus granulosus GPI anchor transamidase 0.0035 0.0095 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Trypanosoma brucei antigen, putative 0.0392 0.2394 0.2365
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0048 0.018 0.0162
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1577 1 1
Brugia malayi Flap endonuclease-1 0.0026 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0095 0.0092
Plasmodium vivax unspecified product 0.0196 0.113 0.2897
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0659 0.0644
Echinococcus multilocularis calpain family protein 1, d 0.0766 0.4792 0.479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0764 0.165
Trypanosoma brucei Component of motile flagella 41 0.0057 0.0238 0.0201
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0118 0.0631 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0255 0.0493
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0659 0.1411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Trypanosoma cruzi cysteine protease, putative 0.0334 0.202 0.2007
Loa Loa (eye worm) CYP4Cod1 0.009 0.045 0.0447
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0452 0.0449
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0177 0.1013 0.255
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0139 0.0764 0.1945
Onchocerca volvulus 0.004 0.0128 0.0124
Loa Loa (eye worm) hypothetical protein 0.0139 0.0764 0.076
Schistosoma mansoni peroxidasin 0.013 0.0708 0.0705
Entamoeba histolytica grainin 2 0.0057 0.0238 0.0524
Echinococcus multilocularis Mastin 0.004 0.0128 0.0124
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.012 0.0117
Mycobacterium ulcerans lipase LipD 0.0043 0.0153 0.0092
Brugia malayi Papain family cysteine protease containing protein 0.0621 0.3862 0.3862
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0596
Trichomonas vaginalis calcium binding protein, putative 0.0057 0.0238 0.0456
Echinococcus granulosus dnaJ subfamily B 0.0423 0.2588 0.2585
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Onchocerca volvulus 0.0621 0.3862 0.386
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Echinococcus granulosus baculoviral IAP repeat containing protein 0.004 0.0127 0.0124
Echinococcus granulosus cpg binding protein 0.0031 0.0075 0.0071
Trichomonas vaginalis calcium binding protein, putative 0.0057 0.0238 0.0456
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0038 0.0023
Leishmania major calcineurin B subunit, putative 0.0057 0.0238 0.0223
Brugia malayi nuclear receptor NHR-88 0.002 0.0004 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.1367 0.8651 0.865
Giardia lamblia Alanyl dipeptidyl peptidase 0.0177 0.1013 0.3728
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0764 0.165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0764 0.165
Entamoeba histolytica calpain large subunit domain III containing protein 0.0274 0.1636 0.4179
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Giardia lamblia Cathepsin B precursor 0.0139 0.0764 0.2775
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0095 0.013
Onchocerca volvulus 0.0139 0.0764 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.0764 0.1898
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2365
Plasmodium vivax centrin-1, putative 0.0057 0.0238 0.0579
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0177 0.1013 0.2217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0171 0.0167
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0048 0.018 0.0162
Brugia malayi Cytochrome P450 family protein 0.009 0.045 0.045
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0048 0.018 0.0162
Trichomonas vaginalis calcineurin B subunit, putative 0.0057 0.0238 0.0456
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.012 0.012
Loa Loa (eye worm) calpain family protein 1 0.0766 0.4792 0.479
Leishmania major i/6 autoantigen-like protein 0.0057 0.0238 0.0223
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.0764 0.1945
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.5014 0.5012
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Leishmania major hypothetical protein, conserved 0.0118 0.0631 0.0617
Onchocerca volvulus 0.005 0.0195 0.0192
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0139 0.0764 0.076
Echinococcus granulosus cathepsin l1 0.0425 0.2606 0.2603
Brugia malayi beta-lactamase family protein 0.0043 0.0153 0.0153
Echinococcus multilocularis hypothetical protein 0.0392 0.2394 0.2391
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0221 0.1293 0.1279
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0065 0.0293 0.072
Entamoeba histolytica calmodulin, putative 0.0057 0.0238 0.0524
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.004 0.0128 0.0124
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0048 0.018 0.0162
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0048 0.018 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0452 0.0449
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1215 0.7675 0.7674
Brugia malayi calpain 7 0.0392 0.2394 0.2394
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.2588 0.2585
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2382
Brugia malayi cathepsin B-like cysteine proteinase 0.109 0.6873 0.6873
Leishmania major hypothetical protein, conserved 0.003 0.0069 0.0054
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0764 0.165
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.012 0.012
Trypanosoma brucei cysteine peptidase C (CPC) 0.0433 0.2653 0.2625
Loa Loa (eye worm) hypothetical protein 0.0153 0.0856 0.0853
Plasmodium falciparum serine repeat antigen 1 0.0139 0.0764 0.1945
Schistosoma mansoni regulator of G protein signaling 0.0038 0.012 0.0117
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0153 0.0149
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0124
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Onchocerca volvulus 0.0648 0.4034 0.4032
Loa Loa (eye worm) calpain family protein 1 0.104 0.6554 0.6553
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1013 0.2217
Entamoeba histolytica cysteine protease, putative 0.0139 0.0764 0.1898
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0293 0.0277
Leishmania major cathepsin L-like protease 0.0621 0.3862 0.3852
Schistosoma mansoni cathepsin B (C01 family) 0.0139 0.0764 0.076
Leishmania major proteasome beta 5 subunit, putative 0.0084 0.0413 0.0398
Leishmania major calmodulin, putative 0.0057 0.0238 0.0223
Brugia malayi calpain 5 0.0118 0.0631 0.0631
Brugia malayi hypothetical protein 0.0038 0.012 0.012
Trichomonas vaginalis calcium binding proteins, putative 0.0057 0.0238 0.0456
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0133 0.0216
Echinococcus granulosus neurocalcin 0.0057 0.0238 0.0235
Trichomonas vaginalis calmodulin-2, putative 0.0057 0.0238 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0004 0.0004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0621 0.3862 0.386
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0139 0.0764 0.165
Brugia malayi Trypsin-like protease protein 5 0.004 0.0128 0.0128
Schistosoma mansoni cytochrome P450 0.0048 0.018 0.0176
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0124
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0196 0.113 0.1126
Brugia malayi hypothetical protein 0.0038 0.012 0.012
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0433 0.2653 0.2642
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0187
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0057 0.0238 0.0223
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1097 0.6919 0.6918
Echinococcus granulosus calumenin 0.0057 0.0243 0.0239
Schistosoma mansoni ap endonuclease 0.0038 0.0118 0.0114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0118 0.0102
Onchocerca volvulus 0.0057 0.0243 0.0239
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0596
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0069 0.014
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0048 0.018 0.0165
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0048 0.018 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0452 0.0449
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0153 0.0153
Schistosoma mansoni calpain-2 (C02 family) 0.0118 0.0631 0.0628
Mycobacterium ulcerans proteasome PrcB 0.0084 0.0413 0.0769
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0333 0.2015 0.2012
Schistosoma mansoni calmodulin related calcium binding protein 0.0057 0.0238 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0048 0.018 0.0071
Echinococcus multilocularis tumor protein p63 0.0342 0.2071 0.2068
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0048 0.018 0.0162
Toxoplasma gondii ABC1 family protein 0.0043 0.0153 0.0138
Loa Loa (eye worm) hypothetical protein 0.0766 0.4792 0.479
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.109 0.6873 0.6868
Brugia malayi hypothetical protein 0.0153 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0425 0.2606 0.2603
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0118 0.0631 0.1349
Plasmodium vivax SET domain protein, putative 0.009 0.0452 0.1135
Onchocerca volvulus Deterin homolog 0.004 0.0127 0.0124
Echinococcus granulosus cytochrome P450 2K1 0.0048 0.018 0.0176
Trypanosoma cruzi cruzipain precursor, putative 0.0196 0.113 0.1116
Schistosoma mansoni regulator of G protein signaling 0.0038 0.012 0.0117
Brugia malayi Pre-SET motif family protein 0.0624 0.3882 0.3882
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0084 0.0413 0.0409
Onchocerca volvulus Cathepsin L homolog 0.0621 0.3862 0.386
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0004 0.0004
Brugia malayi Animal haem peroxidase family protein 0.013 0.0708 0.0708
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0334 0.202 0.2017
Entamoeba histolytica prolyl oligopeptidase family protein 0.0177 0.1013 0.255
Schistosoma mansoni cathepsin s 0.0196 0.113 0.1126
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0095 0.013
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.113 0.1116
Plasmodium vivax vivapain-3 0.0334 0.202 0.5211
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.012 0.0117
Toxoplasma gondii peptidase c13 family protein 0.0035 0.0095 0.008
Plasmodium vivax GPI-anchor transamidase, putative 0.0035 0.0095 0.0208
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0048 0.018 0.0071
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.012 0.0117
Loa Loa (eye worm) prolyl oligopeptidase 0.0333 0.2015 0.2012
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1577 1 1
Brugia malayi Cytochrome P450 family protein 0.0122 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0139 0.0764 0.076
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2394 0.2382
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Loa Loa (eye worm) peptidase C13 family protein 0.0149 0.0829 0.0825
Echinococcus multilocularis acylamino acid releasing enzyme 0.0177 0.1013 0.101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0764 0.076
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.0764 0.076
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0333 0.2015 0.2012
Onchocerca volvulus Peroxidasin homolog 0.013 0.0708 0.0705
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0187
Toxoplasma gondii cathepsin CPL 0.0621 0.3862 0.3852
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0059 0.0255 0.0567
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0139 0.0764 0.1945
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0038 0.0023
Onchocerca volvulus 0.0096 0.0491 0.0487
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1097 0.6919 0.6918
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0334 0.202 0.2017
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0038 0.0034
Schistosoma mansoni ap endonuclease 0.0038 0.0118 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0171 0.0167
Echinococcus multilocularis ubiquitin specific protease 41 0.0059 0.0255 0.0251
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0118 0.5
Schistosoma mansoni hypothetical protein 0.0048 0.018 0.0176
Plasmodium falciparum serine repeat antigen 9 0.0139 0.0764 0.1945
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0829 0.1798
Giardia lamblia Cysteine protease 0.0139 0.0764 0.2775
Schistosoma mansoni neuronal calcium sensor 0.0057 0.0238 0.0235
Brugia malayi hypothetical protein 0.004 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0118 0.0631 0.1349
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0048 0.018 0.0162
Schistosoma mansoni cpg binding protein 0.0031 0.0075 0.0071
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0065 0.0293 0.0665
Schistosoma mansoni cathepsin F (C01 family) 0.0425 0.2606 0.2603
Loa Loa (eye worm) hypothetical protein 0.0621 0.3862 0.386
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0635 0.3953 0.3943
Leishmania major calpain family cysteine protease-like protein 0.0118 0.0631 0.0617
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0118 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0764 0.165
Echinococcus granulosus Mastin 0.004 0.0128 0.0124
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0059 0.0255 0.024
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0177 0.1013 0.2217
Entamoeba histolytica glycogen phosphorylase, putative 0.011 0.0579 0.1414
Trypanosoma brucei prolyl endopeptidase 0.1577 1 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0635 0.3953 0.3943
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0659 0.0655
Trypanosoma cruzi I/6 autoantigen, putative 0.0057 0.0238 0.0223
Brugia malayi PXA domain containing protein 0.0038 0.012 0.012
Mycobacterium leprae putative cytochrome p450 0.0048 0.018 0.0071
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.202 0.202
Entamoeba histolytica cysteine proteinase, putative 0.0334 0.202 0.5183
Giardia lamblia Cathepsin L-like protease 0.0139 0.0764 0.2775
Echinococcus multilocularis GPI anchor transamidase 0.0035 0.0095 0.0092
Loa Loa (eye worm) proteasome subunit beta type 2 0.004 0.0133 0.013
Echinococcus granulosus calpain A 0.0392 0.2394 0.2391
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0149
Brugia malayi EF hand family protein 0.0057 0.0243 0.0243
Trypanosoma brucei Calpain-like protein CALP1.3 0.0118 0.0631 0.0596
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1658 0.1761
Toxoplasma gondii cathepsin CPC1 0.0139 0.0764 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 0.202 0.4507
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0048 0.018 0.0071
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.004 0.0127 0.0124
Schistosoma mansoni calpain C (C02 family) 0.0392 0.2394 0.2391
Loa Loa (eye worm) hypothetical protein 0.0139 0.0764 0.076
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Brugia malayi beta-lactamase family protein 0.0043 0.0153 0.0153
Brugia malayi cathepsin L precursor 0.0139 0.0764 0.0764
Trypanosoma cruzi conserved protein 0.0118 0.0631 0.0617
Echinococcus granulosus calbindin 32 0.0057 0.0243 0.0239
Mycobacterium ulcerans hypothetical protein 0.004 0.0128 0.0027
Trypanosoma cruzi calmodulin, putative 0.0057 0.0238 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0764 0.165
Loa Loa (eye worm) animal heme peroxidase 0.013 0.0708 0.0705
Schistosoma mansoni cpg binding protein 0.0031 0.0075 0.0071
Echinococcus multilocularis centrin 2 0.0057 0.0238 0.0235
Trypanosoma brucei centrin, putative 0.0057 0.0238 0.0201
Entamoeba histolytica cysteine proteinase, putative 0.0621 0.3862 1
Brugia malayi calpain 5 0.0274 0.1636 0.1636
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Brugia malayi Cathepsin L-like precursor 0.0196 0.113 0.113
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0057 0.0238 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Giardia lamblia Cathepsin L precursor 0.0139 0.0764 0.2775
Brugia malayi prolyl oligopeptidase family protein 0.0333 0.2015 0.2015
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0256 0.0241
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0035 0.0095 0.0057
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0139 0.0764 0.1945
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0187
Toxoplasma gondii cytochrome p450 superfamily protein 0.0048 0.018 0.0165
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0153 0.0115
Mycobacterium tuberculosis Conserved protein 0.0043 0.0153 0.004
Giardia lamblia Cathepsin L precursor 0.0139 0.0764 0.2775
Brugia malayi Cathepsin L-like precursor 0.0621 0.3862 0.3862
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0139 0.0764 0.1945
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0004 0.0004
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.0764 0.1898
Mycobacterium leprae Conserved hypothetical protein 0.0048 0.018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0139 0.0764 0.076
Echinococcus multilocularis programmed cell death protein 0.0057 0.0238 0.0235
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0171 0.0167
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0118 0.0631 0.0596
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0035 0.0095 0.008
Echinococcus multilocularis transmembrane protease serine 3 0.004 0.0128 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0043 0.0153 0.0138
Brugia malayi Pre-SET motif family protein 0.009 0.0452 0.0452
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0084 0.0413 0.0398
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0153 0.004
Loa Loa (eye worm) trypsin family protein 0.004 0.0128 0.0124
Schistosoma mansoni memapsin-2 (A01 family) 0.0446 0.2736 0.2734
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.0764 0.1945
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.004 0.0128 0.0128
Trichomonas vaginalis set domain proteins, putative 0.071 0.4435 1
Entamoeba histolytica cysteine protease, putative 0.0139 0.0764 0.1898
Echinococcus multilocularis cathepsin b 0.109 0.6873 0.6872
Echinococcus multilocularis calpain 7 (C02 family) 0.0392 0.2394 0.2391
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0118 0.0305
Loa Loa (eye worm) cytochrome P450 family protein 0.009 0.045 0.0447
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0038 0.0059
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Entamoeba histolytica cysteine proteinase 2 0.0334 0.202 0.5183
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0124
Brugia malayi PXA domain containing protein 0.0038 0.012 0.012
Onchocerca volvulus Peroxidase homolog 0.013 0.0708 0.0705
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0048 0.018 0.0071
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0048 0.018 0.0162
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2382
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.012 0.0117
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2394 0.2365
Echinococcus multilocularis cathepsin L 0.0334 0.202 0.2017
Trypanosoma brucei oligopeptidase b 0.0635 0.3953 0.393
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.012 0.0117
Echinococcus granulosus ubiquitin specific protease 41 0.0059 0.0255 0.0251
Trichomonas vaginalis centrin, putative 0.0057 0.0238 0.0456
Loa Loa (eye worm) hypothetical protein 0.1577 1 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0067 0.0063
Entamoeba histolytica hypothetical protein 0.0038 0.012 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0171 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.202 0.1989
Brugia malayi Cathepsin L-like precursor 0.0621 0.3862 0.3862
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0221 0.1293 0.1259
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0139 0.0764 0.1945
Toxoplasma gondii hypothetical protein 0.0177 0.1013 0.0999
Brugia malayi Trypsin family protein 0.004 0.0128 0.0128
Loa Loa (eye worm) RGS-3 protein 0.0038 0.012 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0764 0.165
Echinococcus multilocularis cathepsin L 0.0139 0.0764 0.076
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0621 0.3862 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0048 0.018 0.0071
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0065 0.0293 0.0289
Onchocerca volvulus 0.0022 0.0016 0.0012
Echinococcus multilocularis cysteine protease 0.0621 0.3862 0.386
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0187
Trypanosoma cruzi kinesin, putative 0.0274 0.1636 0.1623
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0004 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0195 0.0192
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0829 0.1798
Plasmodium falciparum serine repeat antigen 4 0.0139 0.0764 0.1945
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0764 0.0764
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Loa Loa (eye worm) calpain D 0.0118 0.0631 0.0628
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0066
Trichomonas vaginalis myosin light chain 1, putative 0.0057 0.0238 0.0456
Echinococcus multilocularis calpain A 0.1098 0.6923 0.6922
Brugia malayi Animal haem peroxidase family protein 0.013 0.0708 0.0708
Echinococcus multilocularis enteropeptidase 0.004 0.0128 0.0124
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2382
Brugia malayi Calmodulin-like protein 0.0057 0.0238 0.0238
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0133 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0139 0.0764 0.165
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2382
Onchocerca volvulus Cathepsin L homolog 0.0139 0.0764 0.076
Trypanosoma cruzi oligopeptidase b 0.0635 0.3953 0.3943
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Echinococcus granulosus microtubule associated protein 2 0.1367 0.8651 0.865
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0117
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.012 0.012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0764 0.076
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0153 0.0138
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0059 0.0255 0.0493
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Leishmania major phospholipase c-like protein 0.0057 0.0238 0.0223
Echinococcus multilocularis glycoprotein Antigen 5 0.004 0.0128 0.0124
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0084 0.0413 0.098
Schistosoma mansoni calmodulin 0.0057 0.0238 0.0235
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0238 0.0201
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.109 0.6873 0.6872
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.012 0.012
Onchocerca volvulus Cathepsin L homolog 0.0621 0.3862 0.386
Entamoeba histolytica prolyl oligopeptidase family protein 0.0177 0.1013 0.255
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0118 0.0181
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Brugia malayi calcium-binding protein 0.0057 0.0238 0.0238
Schistosoma mansoni regulator of G protein signaling 0.0038 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.109 0.6873 0.6872
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0124
Schistosoma mansoni ef hand domain family member A2 0.0057 0.0238 0.0235
Schistosoma mansoni gamma-secretase subunit aph-1 0.0238 0.1405 0.1401
Entamoeba histolytica cysteine protease, putative 0.0621 0.3862 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0764 0.165
Onchocerca volvulus 0.0621 0.3862 0.386
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0118 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Schistosoma mansoni hypothetical protein 0.0118 0.0631 0.0628
Entamoeba histolytica cysteine proteinase, putative 0.0334 0.202 0.5183
Trichomonas vaginalis calmodulin, putative 0.0057 0.0243 0.0466
Echinococcus multilocularis expressed protein 0.0748 0.4675 0.4673
Echinococcus granulosus EF hand domain containing family member A2 0.0057 0.0243 0.0239
Schistosoma mansoni cathepsin F (C01 family) 0.0621 0.3862 0.386
Loa Loa (eye worm) hypothetical protein 0.0196 0.113 0.1126
Leishmania major centrin, putative 0.0057 0.0238 0.0223
Leishmania major protein kinase, putative 0.0057 0.0238 0.0223
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0084 0.0413 0.0398
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0057 0.0238 0.0235
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0035 0.0095 0.0092
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.012 0.0117
Schistosoma mansoni hypothetical protein 0.004 0.0127 0.0124
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0118 0.0631 0.0617
Schistosoma mansoni glycogen phosphorylase 0.0047 0.0179 0.0175
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0635 0.3953 0.393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0153 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0004 0.0004
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0149 0.0829 0.0825
Echinococcus granulosus calpain 0.0392 0.2394 0.2391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Onchocerca volvulus Glycogen phosphorylase homolog 0.011 0.0579 0.0575
Loa Loa (eye worm) hypothetical protein 0.0425 0.2606 0.2603
Trichomonas vaginalis hypothetical protein 0.0118 0.0631 0.1349
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0059 0.0255 0.024
Plasmodium vivax unspecified product 0.0334 0.202 0.5211
Onchocerca volvulus 0.0043 0.0153 0.0149
Trypanosoma cruzi cysteine peptidase, putative 0.0715 0.4467 0.4459
Loa Loa (eye worm) hypothetical protein 0.0177 0.1013 0.101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.0334 0.202 0.5183
Plasmodium falciparum serine repeat antigen 8 0.0139 0.0764 0.1945
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.012 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Schistosoma mansoni glycogen phosphorylase 0.011 0.0579 0.0575
Brugia malayi cytochrome P450 0.0048 0.018 0.018
Schistosoma mansoni peroxidasin 0.013 0.0708 0.0705
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.047 0.0455
Entamoeba histolytica cysteine protease, putative 0.0139 0.0764 0.1898
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0118 0.008
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0048 0.018 0.0162
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0433 0.2653 0.265
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0196 0.113 0.113
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Brugia malayi GPI-anchor transamidase 0.0035 0.0095 0.0095
Echinococcus granulosus cathepsin L cysteine proteinase 0.0621 0.3862 0.386
Entamoeba histolytica calmodulin, putative 0.0057 0.0238 0.0524
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.0764 0.2775
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.012 0.0117
Onchocerca volvulus Chorion peroxidase homolog 0.013 0.0708 0.0705
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0635 0.3953 0.3943
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0221 0.1293 0.1279
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0631 0.0617
Echinococcus multilocularis caspase 2 0.003 0.0067 0.0063
Brugia malayi Cathepsin L-like precursor 0.0621 0.3862 0.3862
Onchocerca volvulus 0.004 0.0127 0.0124
Brugia malayi Protein kinase domain containing protein 0.0022 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0149
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0133 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0764 0.165
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0139 0.0764 0.1945
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Schistosoma mansoni reticulocalbin 0.0057 0.0243 0.0239
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0334 0.202 0.2017
Plasmodium falciparum serine repeat antigen 5 0.0139 0.0764 0.1945
Trypanosoma cruzi 20S proteasome subunit 0.004 0.0133 0.0118
Echinococcus multilocularis calpain 5 0.0392 0.2394 0.2391
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0057 0.0243 0.0228
Toxoplasma gondii cathepsin CPC2 0.0139 0.0764 0.0749
Echinococcus granulosus peroxidasin 0.013 0.0708 0.0705
Loa Loa (eye worm) hypothetical protein 0.0139 0.0764 0.076
Leishmania major centrin, putative 0.0057 0.0238 0.0223
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trypanosoma cruzi cytochrome P450, putative 0.009 0.045 0.0436
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0048 0.018 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0631 0.1349
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.009 0.0452 0.0449
Echinococcus multilocularis gamma secretase subunit aph 1 0.0238 0.1405 0.1401
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0221 0.1293 0.1279
Plasmodium vivax vivapain-1 0.0334 0.202 0.5211
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Schistosoma mansoni hypothetical protein 0.0057 0.0238 0.0235
Echinococcus multilocularis inhibitor of apoptosis protein 0.004 0.0127 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0621 0.3862 0.386
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0067 0.0063
Trypanosoma brucei protein I/6 0.0057 0.0238 0.0201
Echinococcus granulosus prolyl endopeptidase 0.1577 1 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.004 0.0128 0.0124
Echinococcus granulosus expressed protein 0.0748 0.4675 0.4673
Loa Loa (eye worm) blistered cuticle protein 3 0.013 0.0708 0.0705
Echinococcus multilocularis calcium uptake protein 1 0.0057 0.0243 0.0239
Entamoeba histolytica hypothetical protein 0.0139 0.0764 0.1898
Brugia malayi prolyl oligopeptidase family protein 0.0221 0.1293 0.1293
Brugia malayi Cathepsin L-like precursor 0.0621 0.3862 0.3862
Brugia malayi Peroxidasin 0.013 0.0708 0.0708
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.0243 0.0535
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0764 0.0764
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.012 0.0117
Onchocerca volvulus Peroxidasin homolog 0.013 0.0708 0.0705
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0124
Brugia malayi Papain family cysteine protease containing protein 0.0334 0.202 0.202
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1097 0.6919 0.6918
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0221 0.1293 0.1289
Brugia malayi carbohydrate phosphorylase 0.011 0.0579 0.0579
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0621 0.3862 0.386
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0221 0.1293 0.1259
Giardia lamblia GPI-anchor transamidase, putative 0.0035 0.0095 0.0219
Trypanosoma cruzi cruzipain precursor, putative 0.0715 0.4467 0.4459
Toxoplasma gondii centrin 0.0057 0.0238 0.0223
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0048 0.018 0.0162
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Echinococcus granulosus inhibitor of apoptosis protein 0.004 0.0127 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0149
Trypanosoma cruzi centrin-3 0.0057 0.0238 0.0223
Trichomonas vaginalis calpain, putative 0.0118 0.0631 0.1349
Trypanosoma brucei calmodulin, putative 0.0057 0.0238 0.0201
Echinococcus granulosus calpain 5 0.0392 0.2394 0.2391
Echinococcus granulosus enteropeptidase 0.004 0.0128 0.0124
Echinococcus multilocularis cathepsin b 0.109 0.6873 0.6872
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Loa Loa (eye worm) EF hand family protein 0.0057 0.0238 0.0235
Brugia malayi Angiotensin-converting enzyme family protein 0.1215 0.7675 0.7675
Giardia lamblia Cathepsin B precursor 0.0139 0.0764 0.2775
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0118 0.0631 0.0596
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0118 0.0266
Echinococcus multilocularis cathepsin L cysteine protease 0.0621 0.3862 0.386
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0596
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0048 0.018 0.0162
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0635 0.3953 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0153 0.0092
Entamoeba histolytica prolyl oligopeptidase family protein 0.0177 0.1013 0.255
Plasmodium vivax proteasome subunit beta type-1, putative 0.0065 0.0293 0.072
Giardia lamblia Cathepsin B precursor 0.0139 0.0764 0.2775
Toxoplasma gondii calcium-dependent protein kinase 0.0057 0.0243 0.0228
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0829 0.1798
Schistosoma mansoni mitochondrial solute carrier 0.0057 0.0238 0.0235
Trypanosoma brucei centrin-3 0.0057 0.0238 0.0201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0153 0.0149
Loa Loa (eye worm) cytochrome P450 family protein 0.0122 0.066 0.0657
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0124
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0069 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Onchocerca volvulus 0.0043 0.0153 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.0425 0.2606 0.6715
Entamoeba histolytica cysteine protease, putative 0.0139 0.0764 0.1898
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.012 0.0117
Giardia lamblia Cathepsin L-like protease 0.0139 0.0764 0.2775
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0139 0.0764 0.165
Echinococcus multilocularis calmodulin 0.0057 0.0238 0.0235
Onchocerca volvulus Peroxidase homolog 0.013 0.0708 0.0705
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0048 0.018 0.0162
Echinococcus granulosus calcium uptake protein 1 0.0057 0.0243 0.0239
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0057 0.0238 0.0235
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0153 0.0092
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0048 0.018 0.0162
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0057 0.0238 0.0201
Loa Loa (eye worm) hypothetical protein 0.0177 0.1013 0.101
Plasmodium falciparum serine repeat antigen 2 0.0139 0.0764 0.1945
Entamoeba histolytica GPI-anchor transamidase, putative 0.0035 0.0095 0.015
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0829 0.1798
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0048 0.018 0.0162
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0124
Trypanosoma brucei kinesin, putative 0.0274 0.1636 0.1604
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0764 0.0764
Entamoeba histolytica cysteine protease, putative 0.0139 0.0764 0.1898
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0177 0.1013 0.0979
Onchocerca volvulus 0.0621 0.3862 0.386
Echinococcus multilocularis cpg binding protein 0.0031 0.0075 0.0071
Schistosoma mansoni cathepsin C 0.0139 0.0764 0.076
Brugia malayi Cathepsin L-like precursor 0.0425 0.2606 0.2606
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.012 0.0117
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Brugia malayi steroid hormone receptor 0.002 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0139 0.0764 0.165
Echinococcus granulosus neuronal calcium sensor 0.0057 0.0238 0.0235
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.2898 0.2895
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0118 0.0631 0.1349
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0621 0.3862 0.386
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0659 0.0655
Brugia malayi Blistered cuticle protein 3 0.013 0.0708 0.0708
Brugia malayi prolyl oligopeptidase family protein 0.0177 0.1013 0.1013
Plasmodium falciparum calpain 0.0118 0.0631 0.1601
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.004 0.0127 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Trichomonas vaginalis calcium binding protein, putative 0.0057 0.0238 0.0456
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0764 0.076
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0118 0.0631 0.0617
Trypanosoma cruzi cysteine proteinase, putative 0.0334 0.202 0.2007
Schistosoma mansoni centrin 0.0057 0.0238 0.0235
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0153 0.0261
Trypanosoma brucei Calpain-like protein 1.1 0.0118 0.0631 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0004 0.0004
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0221 0.1293 0.1279
Onchocerca volvulus 0.004 0.0128 0.0124
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0139 0.0764 0.1945
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0035 0.0095 0.008
Entamoeba histolytica grainin, putative 0.0057 0.0243 0.0535
Echinococcus granulosus Glycosyl transferase family 35 0.011 0.0579 0.0575
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0067 0.0063
Toxoplasma gondii centrin, putative 0.0057 0.0238 0.0223
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.0764 0.2775
Leishmania major cathepsin L-like protease 0.0621 0.3862 0.3852
Giardia lamblia Proteasome subunit beta type 1 0.0065 0.0293 0.0973
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0059 0.0255 0.0251
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0057 0.0243 0.0239
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0048 0.018 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 0.202 0.1989
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0333 0.2015 0.2012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0764 0.165
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0069 0.014
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0059 0.0255 0.0251
Entamoeba histolytica protein kinase, putative 0.0274 0.1636 0.4179
Giardia lamblia Hypothetical protein 0.0139 0.0764 0.2775
Onchocerca volvulus 0.003 0.0064 0.0061
Echinococcus granulosus cathepsin l1 0.0621 0.3862 0.386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0057 0.0238 0.0223
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0048 0.018 0.0071
Trypanosoma cruzi major cysteine proteinase, putative 0.0139 0.0764 0.0749
Giardia lamblia Glycogen phosphorylase 0.011 0.0579 0.2068
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0118 0.0631 0.0617
Trypanosoma brucei calmodulin, putative 0.0057 0.0243 0.0206
Toxoplasma gondii calmodulin CAM1 0.0057 0.0243 0.0228
Entamoeba histolytica hypothetical protein 0.0038 0.012 0.0215
Brugia malayi hypothetical protein 0.0471 0.2898 0.2898
Toxoplasma gondii troponin c, isotype gamma, putative 0.0057 0.0238 0.0223
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1097 0.6919 0.6918
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0635 0.3953 0.4386
Plasmodium falciparum GPI-anchor transamidase, putative 0.0035 0.0095 0.0208
Onchocerca volvulus 0.071 0.4437 0.4435
Plasmodium vivax vivapain-2 0.0621 0.3862 1
Onchocerca volvulus 0.0621 0.3862 0.386
Plasmodium vivax proteasome subunit beta type-5, putative 0.0084 0.0413 0.1033
Echinococcus granulosus proteasome prosome macropain subunit beta 0.004 0.0133 0.013
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.004 0.0127 0.0127
Loa Loa (eye worm) cytochrome P450 family protein 0.009 0.045 0.0447
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0392 0.2394 0.2382
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0153 0.004
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0057 0.0238 0.0223
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0048 0.018 0.0142
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0153 0.0261
Plasmodium vivax hypothetical protein, conserved 0.0177 0.1013 0.2593
Leishmania major calmodulin-like protein 0.0057 0.0238 0.0223
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0153 0.004
Onchocerca volvulus 0.0621 0.3862 0.386
Leishmania major programmed cell death 6 protein-like protein 0.0057 0.0238 0.0223
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0635 0.3953 1
Brugia malayi hypothetical protein 0.003 0.0069 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0004 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0048 0.018 0.0071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.052 0.3211 0.3201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.012 0.012
Onchocerca volvulus 0.0621 0.3862 0.386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0048 0.018 0.0071
Echinococcus granulosus glycoprotein Antigen 5 0.004 0.0128 0.0124
Loa Loa (eye worm) beta-lactamase 0.0043 0.0153 0.0149
Loa Loa (eye worm) hypothetical protein 0.0057 0.0238 0.0235
Trichomonas vaginalis glycogen phosphorylase, putative 0.011 0.0579 0.123
Echinococcus multilocularis EF hand domain containing family member A2 0.0057 0.0238 0.0235
Loa Loa (eye worm) ctsf protein 0.0621 0.3862 0.386
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Giardia lamblia Encystation-specific protease 0.0139 0.0764 0.2775
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0057 0.0238 0.0456
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0139 0.0764 0.1945
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0057 0.0238 0.0223
Giardia lamblia Cysteine protease 0.0139 0.0764 0.2775
Brugia malayi Kringle domain containing protein 0.0022 0.0016 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0118 0.0114
Mycobacterium tuberculosis Conserved protein 0.0043 0.0153 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0187
Entamoeba histolytica hypothetical protein, conserved 0.0177 0.1013 0.255
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0047 0.0179 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2394 0.2382
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0153 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0004 0.0004
Onchocerca volvulus Dual oxidase homolog 0.013 0.0708 0.0705
Echinococcus granulosus programmed cell death protein 0.0057 0.0238 0.0235
Plasmodium vivax vivapain-2 0.0621 0.3862 1
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Schistosoma mansoni regulator of G protein signaling 0.0038 0.012 0.0117
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0069 0.0031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0118 0.0114
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0139 0.0764 0.1945
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0067 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0177 0.1013 0.0999
Schistosoma mansoni survival motor neuron protein 0.0096 0.0491 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.012 0.0187
Brugia malayi proteasome subunit beta type 1 0.0065 0.0293 0.0293
Echinococcus multilocularis EF hand domain containing family member A2 0.0057 0.0243 0.0239
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2394 0.2382
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0059 0.0255 0.024
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.012 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0715 0.4467 0.4459
Trypanosoma cruzi calmodulin, putative 0.0057 0.0238 0.0223
Loa Loa (eye worm) prolyl oligopeptidase 0.0177 0.1013 0.101
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.012 0.0117
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2394 0.2365
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Entamoeba histolytica calcium binding family protein 0.0057 0.0238 0.0524
Echinococcus multilocularis programmed cell death protein 0.0057 0.0238 0.0235
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0048 0.018 0.0162
Schistosoma mansoni hypothetical protein 0.0096 0.0491 0.0487
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.047 0.0455
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1577 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0177 0.1013 0.0999
Giardia lamblia Alanyl dipeptidyl peptidase 0.0177 0.1013 0.3728
Brugia malayi fibroinase precursor 0.0139 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0124
Echinococcus granulosus cathepsin L 0.0139 0.0764 0.076
Schistosoma mansoni hypothetical protein 0.0114 0.0607 0.0604
Brugia malayi beta-lactamase 0.0043 0.0153 0.0153
Echinococcus multilocularis peroxidasin 0.013 0.0708 0.0705
Plasmodium falciparum proteasome subunit beta type-2, putative 0.004 0.0133 0.0306
Echinococcus granulosus tumor protein p63 0.0342 0.2071 0.2068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0171 0.0167
Loa Loa (eye worm) hypothetical protein 0.0471 0.2898 0.2895
Toxoplasma gondii hypothetical protein 0.0118 0.0631 0.0617
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.0764 0.1945
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.012 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0057 0.0238 0.0223
Schistosoma mansoni glycogen phosphorylase 0.011 0.0579 0.0575
Echinococcus granulosus Dipeptidyl peptidase 9 0.0221 0.1293 0.1289
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0764 0.165
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0117
Brugia malayi Cathepsin L-like precursor 0.0621 0.3862 0.3862
Mycobacterium tuberculosis Probable peptidase 0.0635 0.3953 0.4386
Brugia malayi cathepsin L-like precursor 0.0425 0.2606 0.2606
Trichomonas vaginalis esterase, putative 0.0043 0.0153 0.0261
Entamoeba histolytica cysteine proteinase, putative 0.0621 0.3862 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0118 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0764 0.165
Trypanosoma cruzi cysteine peptidase, putative 0.0334 0.202 0.2007
Trypanosoma cruzi oligopeptidase b 0.0635 0.3953 0.3943
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0621 0.3862 0.8696
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0392 0.2394 0.2365
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0057 0.0238 0.0223
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0048 0.018 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Brugia malayi nuclear hormone receptor 0.002 0.0004 0.0004
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0333 0.2015 0.2012
Echinococcus granulosus glycogen phosphorylase 0.011 0.0579 0.0575
Leishmania major centrin, putative,caltractin, putative 0.0057 0.0238 0.0223
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0659 0.0655
Echinococcus multilocularis calmodulin 0.0057 0.0238 0.0235
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Loa Loa (eye worm) calpain 0.0392 0.2394 0.2391
Giardia lamblia Hypothetical protein 0.0139 0.0764 0.2775
Trypanosoma cruzi prolyl endopeptidase 0.1577 1 1
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Entamoeba histolytica calcium-binding protein, putative 0.0057 0.0238 0.0524
Loa Loa (eye worm) hypothetical protein 0.0648 0.4034 0.4032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0004 0.0004
Toxoplasma gondii EFHC1, putative 0.0057 0.0238 0.0223
Loa Loa (eye worm) hypothetical protein 0.0196 0.113 0.1126
Toxoplasma gondii EF hand domain-containing protein 0.0057 0.0238 0.0223
Schistosoma mansoni neuronal calcium sensor 0.0057 0.0238 0.0235
Echinococcus multilocularis Glycosyl transferase, family 35 0.011 0.0579 0.0575
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.109 0.6873 0.6872
Giardia lamblia Cysteine protease 0.0139 0.0764 0.2775
Echinococcus granulosus transmembrane protease serine 3 0.004 0.0128 0.0124
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0057 0.0238 0.0524
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0117
Leishmania major kinesin, putative 0.0274 0.1636 0.1623
Echinococcus granulosus gamma secretase subunit aph 1 0.0238 0.1405 0.1401
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0334 0.202 0.2007
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0048 0.018 0.0165
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0659 0.0619
Onchocerca volvulus Legumain homolog 0.0149 0.0829 0.0825
Schistosoma mansoni hemoglobinase (C13 family) 0.0149 0.0829 0.0825
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0048 0.018 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0452 0.0449
Brugia malayi cathepsin L-like cysteine proteinase 0.0139 0.0764 0.0764
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0048 0.018 0.0071
Schistosoma mansoni neuronal calcium sensor 0.0057 0.0238 0.0235
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0059 0.0255 0.0251
Entamoeba histolytica cysteine protease, putative 0.0139 0.0764 0.1898
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0621 0.3862 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0128 0.0124
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0038 0.0023
Loa Loa (eye worm) animal heme peroxidase 0.013 0.0708 0.0705
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0124
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0829 0.1798
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0392 0.2394 0.2382
Schistosoma mansoni hypothetical protein 0.0022 0.0016 0.0012
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Plasmodium vivax unspecified product 0.0139 0.0764 0.1945
Echinococcus multilocularis prolyl endopeptidase 0.1577 1 1
Echinococcus granulosus cathepsin b 0.109 0.6873 0.6872
Onchocerca volvulus 0.0057 0.0238 0.0235
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0059 0.0255 0.0251
Schistosoma mansoni hypothetical protein 0.003 0.0067 0.0063
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.2898 0.2895
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0829 0.1798
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1399 0.8861 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.104 0.6554 0.6553
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0048 0.018 0.0071
Brugia malayi Peptidase C13 family protein 0.0149 0.0829 0.0829
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0764 0.165
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0118 0.0631 0.1349
Brugia malayi hypothetical protein 0.003 0.0067 0.0067
Schistosoma mansoni inhibitor of apoptosis protein 0.004 0.0127 0.0124
Echinococcus granulosus calmodulin 0.0057 0.0238 0.0235
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Trichomonas vaginalis calcineurin B subunit, putative 0.0057 0.0243 0.0466
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0038 0.012 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0171 0.0167
Schistosoma mansoni hypothetical protein 0.0057 0.0238 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0048 0.018 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0048 0.018 0.0071
Echinococcus multilocularis glycogen phosphorylase 0.011 0.0579 0.0575
Brugia malayi calpain D 0.0118 0.0631 0.0631
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0139 0.0764 0.0764
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2394 0.2382
Echinococcus granulosus cathepsin L cysteine protease 0.0334 0.202 0.2017
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.004 0.0133 0.0249
Trypanosoma cruzi calmodulin, putative 0.0057 0.0238 0.0223
Schistosoma mansoni neuronal calcium sensor 0.0057 0.0238 0.0235
Loa Loa (eye worm) calpain 5 0.0274 0.1636 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0238 0.0456
Schistosoma mansoni calpain-7 (C02 family) 0.0397 0.2425 0.2422
Loa Loa (eye worm) hypothetical protein 0.0425 0.2606 0.2603
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0392 0.2394 0.2382
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.004 0.0127 0.0127
Trypanosoma cruzi cytochrome P450, putative 0.009 0.045 0.0436
Trypanosoma brucei Calpain-like protein 1.2 0.0118 0.0631 0.0596
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Onchocerca volvulus 0.009 0.0452 0.0449
Echinococcus granulosus flap endonuclease 1 0.0026 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0196 0.113 0.1126
Toxoplasma gondii preprocathepsin c precursor, putative 0.0139 0.0764 0.0749
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0065 0.0293 0.0289
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0084 0.0413 0.1433
Schistosoma mansoni cpg binding protein 0.003 0.0064 0.0061
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0048 0.018 0.0162
Trichomonas vaginalis glycogen phosphorylase, putative 0.011 0.0579 0.123
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0064 0.0061
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0153 0.0261
Echinococcus multilocularis calpain 0.0392 0.2394 0.2391
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0621 0.3862 0.8696
Plasmodium falciparum flap endonuclease 1 0.0026 0.0038 0.0059
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0048 0.018 0.0162
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0153 0.0149
Loa Loa (eye worm) cathepsin B 0.0433 0.2653 0.265
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0293 0.0277
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0048 0.018 0.0071
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0139 0.0764 0.2775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.109 0.6873 0.6872
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0059 0.0255 0.0251
Loa Loa (eye worm) animal heme peroxidase 0.013 0.0708 0.0705
Plasmodium vivax calpain, putative 0.0392 0.2394 0.6183
Onchocerca volvulus Cathepsin F homolog 0.0621 0.3862 0.386
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0621 0.3862 0.8696
Schistosoma mansoni flap endonuclease-1 0.0023 0.0022 0.0019
Onchocerca volvulus 0.013 0.0708 0.0705
Onchocerca volvulus Prolyl endopeptidase homolog 0.1577 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0004 0.0004
Echinococcus multilocularis calumenin 0.0057 0.0243 0.0239
Mycobacterium ulcerans hypothetical protein 0.0043 0.0153 0.0092
Brugia malayi hypothetical protein 0.0044 0.0153 0.0153
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0149 0.0829 0.1798
Brugia malayi calpain family protein 1 0.104 0.6554 0.6554
Echinococcus multilocularis calbindin 32 0.0057 0.0243 0.0239
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.012 0.0187
Plasmodium falciparum cysteine proteinase falcipain 3 0.0621 0.3862 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0048 0.018 0.0071
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.012 0.0117
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0139 0.0764 0.2775
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0631 0.0617
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0118 0.0118
Echinococcus multilocularis glycogen phosphorylase 0.011 0.0579 0.0575
Plasmodium falciparum peptidase, putative 0.0177 0.1013 0.2593
Loa Loa (eye worm) proteasome subunit beta type 1 0.0065 0.0293 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0238 0.0456
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Trypanosoma cruzi I/6 autoantigen, putative 0.0057 0.0238 0.0223
Leishmania major cathepsin L-like protease 0.0621 0.3862 0.3852
Brugia malayi Animal haem peroxidase family protein 0.013 0.0708 0.0708
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0038 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0425 0.2606 0.584
Onchocerca volvulus 0.0057 0.0238 0.0235
Echinococcus multilocularis cathepsin L cysteine protease 0.0621 0.3862 0.386
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0059 0.0255 0.0218
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0153 0.004
Trypanosoma brucei proteasome subunit beta type-2, putative 0.004 0.0133 0.0096
Echinococcus granulosus centrin 2 0.0057 0.0238 0.0235
Mycobacterium tuberculosis Conserved protein 0.0043 0.0153 0.004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0452 0.0449
Leishmania major hypothetical protein, conserved 0.0057 0.0243 0.0228
Giardia lamblia Cathepsin B precursor 0.0139 0.0764 0.2775
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0153 0.004
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0084 0.0413 0.0337
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Echinococcus granulosus cathepsin l cysteine peptidase 0.0621 0.3862 0.386
Schistosoma mansoni microtubule-associated protein tau 0.1367 0.8651 0.865
Schistosoma mansoni calpain (C02 family) 0.0392 0.2394 0.2391
Leishmania major cytochrome p450-like protein 0.0048 0.018 0.0165
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0059 0.0255 0.0493
Trypanosoma brucei proteasome beta 6 subunit 0.0065 0.0293 0.0255
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0153 0.0261
Plasmodium vivax proteasome subunit beta type-2, putative 0.004 0.0133 0.0306
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0153 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Brugia malayi calpain family protein 1 0.104 0.6554 0.6554
Trichomonas vaginalis calpain, putative 0.0118 0.0631 0.1349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Chlamydia trachomatis glycogen phosphorylase 0.011 0.0579 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0491 0.0491
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0631 0.0617
Toxoplasma gondii cathepsin B 0.0433 0.2653 0.2642
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.012 0.0117
Plasmodium falciparum centrin-1 0.0057 0.0238 0.0579
Echinococcus multilocularis cysteine protease 0.0621 0.3862 0.386
Giardia lamblia Cathepsin L precursor 0.0139 0.0764 0.2775
Trypanosoma cruzi centrin, putative 0.0057 0.0238 0.0223
Entamoeba histolytica glycogen phosphorylase, putative 0.011 0.0579 0.1414
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0065 0.0293 0.0277
Entamoeba histolytica hypothetical protein 0.0038 0.012 0.0215
Loa Loa (eye worm) glycogen phosphorylase 0.011 0.0579 0.0575
Loa Loa (eye worm) fibroinase 0.0621 0.3862 0.386
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0177 0.1013 0.255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0171 0.0167
Trypanosoma cruzi kinesin, putative 0.0274 0.1636 0.1623
Trypanosoma brucei cysteine peptidase, putative 0.0118 0.0631 0.0596
Brugia malayi ecdysteroid receptor 0.002 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0117
Leishmania major cathepsin L-like protease 0.0715 0.4467 0.4459
Schistosoma mansoni hypothetical protein 0.0423 0.2588 0.2585
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.012 0.0117
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0118 0.0631 0.1349
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.012 0.0117
Brugia malayi Animal haem peroxidase family protein 0.013 0.0708 0.0708
Plasmodium falciparum serine repeat antigen 7 0.0139 0.0764 0.1945
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.012 0.0117
Onchocerca volvulus 0.0425 0.2606 0.2603
Leishmania major cathepsin L-like protease 0.0715 0.4467 0.4459
Giardia lamblia Cathepsin B precursor 0.0433 0.2653 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0299 0.0296
Echinococcus granulosus caspase 2 0.003 0.0067 0.0063
Onchocerca volvulus 0.013 0.0708 0.0705
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0069 0.0054
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0065 0.0293 0.0289
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0153 0.0138
Trypanosoma brucei caltractin, putative 0.0057 0.0238 0.0201
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.004 0.0133 0.013
Trypanosoma cruzi cysteine peptidase, putative 0.0621 0.3862 0.3852
Trypanosoma brucei calpain-like protein, putative 0.0392 0.2394 0.2365
Trypanosoma brucei I/6 autoantigen 0.0057 0.0238 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0004 0.0004
Echinococcus granulosus calpain A 0.1098 0.6923 0.6922
Loa Loa (eye worm) cysteine protease 0.0621 0.3862 0.386
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0139 0.0764 0.076
Trypanosoma brucei Calpain-like protein 2 0.0118 0.0631 0.0596
Schistosoma mansoni reticulocalbin 0.0057 0.0238 0.0235
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0016 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0433 0.2653 0.5947
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.012 0.0117
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0118 0.0102
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.012 0.0117
Onchocerca volvulus 0.0043 0.0153 0.0149
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.0764 0.0764
Echinococcus granulosus axis inhibition protein axin 0.0038 0.012 0.0117
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.0764 0.076
Loa Loa (eye worm) hypothetical protein 0.0922 0.5797 0.5795
Leishmania major calmodulin, putative 0.0057 0.0238 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Echinococcus granulosus EF HAND 1 calcium binding site 0.0057 0.0238 0.0235
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0433 0.2653 0.2642
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0069 0.0054
Toxoplasma gondii exonuclease III APE 0.0038 0.0118 0.0102
Leishmania major cysteine peptidase A (CPA) 0.0621 0.3862 0.3852
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.0179 0.0367
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.012 0.0117
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0452 0.0449
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0179 0.0367
Giardia lamblia Proteasome subunit beta type 2 0.004 0.0133 0.0364
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0153 0.0261
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.0631 0.0617
Brugia malayi Trypsin family protein 0.004 0.0128 0.0128
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0057 0.0238 0.0579
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0139 0.0764 0.076
Trypanosoma brucei centrin, putative 0.0057 0.0238 0.0201
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0057 0.0238 0.0235
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0659 0.1411
Trypanosoma cruzi major cysteine proteinase, putative 0.0233 0.1369 0.1356
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0128 0.0124
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0057 0.0238 0.0456
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0764 0.076
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0715 0.4467 0.4446
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0153 0.0149
Brugia malayi CXXC zinc finger family protein 0.003 0.0064 0.0064
Brugia malayi EF hand family protein 0.0057 0.0238 0.0238
Trypanosoma brucei Aph-1 protein, putative 0.0093 0.047 0.0434
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0059 0.0255 0.0251
Schistosoma mansoni axis inhibition protein axin 0.0038 0.012 0.0117
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.004 0.0128 0.0124
Trypanosoma cruzi cysteine peptidase, putative 0.0715 0.4467 0.4459
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.0764 0.1945
Echinococcus granulosus cathepsin b 0.109 0.6873 0.6872
Brugia malayi Cathepsin L-like precursor 0.0621 0.3862 0.3862
Loa Loa (eye worm) hypothetical protein 0.013 0.0708 0.0705
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0128 0.0124
Echinococcus granulosus EF hand domain containing family member A2 0.0057 0.0238 0.0235
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0624 0.3882 0.388
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.009 0.045 0.0867
Plasmodium falciparum serine repeat antigen 3 0.0139 0.0764 0.1945
Loa Loa (eye worm) hypothetical protein 0.0118 0.0631 0.0628
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0659 0.0655
Giardia lamblia Cathepsin L precursor 0.0139 0.0764 0.2775
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0124
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0659 0.1411
Brugia malayi Trypsin family protein 0.004 0.0128 0.0128
Trypanosoma brucei prolyl oligopeptidase, putative 0.0635 0.3953 0.393
Trypanosoma brucei mitochondrial calcium uptake 1 0.0057 0.0238 0.0201
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0177 0.1013 0.101
Echinococcus granulosus axis inhibition protein axin 0.0038 0.012 0.0117
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.0631 0.0596
Giardia lamblia Cathepsin B precursor 0.0433 0.2653 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0048 0.018 0.0162
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0179 0.0367
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0621 0.3862 0.386
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0139 0.0764 0.1945
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0133 0.013
Leishmania major cathepsin L-like protease 0.0621 0.3862 0.3852
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0153 0.0357
Trichomonas vaginalis calpain, putative 0.0118 0.0631 0.1349
Trichomonas vaginalis calmodulin, putative 0.0057 0.0238 0.0456
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0452 0.0449
Trypanosoma cruzi cysteine proteinase, putative 0.0334 0.202 0.2007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0425 0.2606 0.584
Schistosoma mansoni rab 0.0057 0.0238 0.0235
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0059 0.0255 0.0251
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0084 0.0413 0.0376
Schistosoma mansoni calpain-7 (C02 family) 0.0397 0.2425 0.2422
Giardia lamblia Cysteine protease 0.0139 0.0764 0.2775
Leishmania major proteasome beta 2 subunit, putative 0.004 0.0133 0.0118
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.0631 0.0617
Schistosoma mansoni cathepsin S (C01 family) 0.0139 0.0764 0.076
Trichomonas vaginalis centrin, putative 0.0057 0.0238 0.0456
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0016 0.0012
Entamoeba histolytica cysteine protease, putative 0.0334 0.202 0.5183
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0452 0.0437
Brugia malayi proteasome subunit beta type 2 0.004 0.0133 0.0133
Giardia lamblia Cathepsin B precursor 0.0139 0.0764 0.2775
Loa Loa (eye worm) animal heme peroxidase 0.013 0.0708 0.0705
Onchocerca volvulus 0.003 0.0067 0.0063
Giardia lamblia Cathepsin B precursor 0.0433 0.2653 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.012 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0764 0.165
Toxoplasma gondii prolyl endopeptidase 0.1577 1 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0084 0.0413 0.0852
Loa Loa (eye worm) hypothetical protein 0.0044 0.0153 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0621 0.3862 0.8696
Schistosoma mansoni hemoglobinase (C13 family) 0.0149 0.0829 0.0825
Leishmania major calpain protease-like protein 0.0118 0.0631 0.0617
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0048 0.018 0.0162
Plasmodium falciparum serine repeat antigen 6 0.0139 0.0764 0.1945
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.012 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0048 0.018 0.0071

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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