Detailed information for compound 309055

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.475 | Formula: C24H27NO5
  • H donors: 2 H acceptors: 4 LogP: 1.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C/C(=O)O.CN(CC/C=C\1/c2cc(C)ccc2OCc2c1cccc2)C
  • InChi: 1S/C20H23NO.C4H4O4/c1-15-10-11-20-19(13-15)18(9-6-12-21(2)3)17-8-5-4-7-16(17)14-22-20;5-3(6)1-2-4(7)8/h4-5,7-11,13H,6,12,14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b18-9+;2-1+
  • InChiKey: MOGGBIGEZRQVAV-WDHMBXCWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Histamine H1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Histamine H1 receptor   488 aa 486 aa 26.5 %
Echinococcus multilocularis serotonin receptor Histamine H1 receptor   488 aa 450 aa 26.0 %
Echinococcus multilocularis biogenic amine (5HT) receptor Histamine H1 receptor   488 aa 485 aa 26.4 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H1 receptor   488 aa 455 aa 25.5 %
Echinococcus multilocularis alpha 1A adrenergic receptor Histamine H1 receptor   488 aa 454 aa 19.4 %
Schistosoma japonicum Octopamine receptor, putative Histamine H1 receptor   488 aa 472 aa 25.8 %
Loa Loa (eye worm) TYRA-2 protein Histamine H1 receptor   488 aa 489 aa 23.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Histamine H1 receptor   488 aa 470 aa 26.0 %
Echinococcus granulosus alpha 1A adrenergic receptor Histamine H1 receptor   488 aa 455 aa 19.1 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H1 receptor   488 aa 484 aa 26.9 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Histamine H1 receptor   488 aa 488 aa 26.6 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Histamine H1 receptor   488 aa 482 aa 25.1 %
Schistosoma mansoni biogenic amine receptor Histamine H1 receptor   488 aa 487 aa 25.5 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Histamine H1 receptor   488 aa 463 aa 26.6 %
Schistosoma mansoni biogenic amine (dopamine) receptor Histamine H1 receptor   488 aa 498 aa 26.1 %
Schistosoma mansoni biogenic amine (dopamine) receptor Histamine H1 receptor   488 aa 471 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0216 0.0216
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0216 0.0216
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0113 0.0501 0.0501
Leishmania major phospholipase c-like protein 0.0111 0.0488 0.0681
Echinococcus granulosus proteasome prosome macropain 0.0082 0.0331 0.0331
Plasmodium vivax importin-beta 2, putative 0.0028 0.004 0.0116
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0597 0.3106 0.3106
Trypanosoma cruzi oligopeptidase b 0.0553 0.2871 0.2871
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1843 0.9822 0.9822
Trypanosoma brucei prolyl oligopeptidase, putative 0.0553 0.2871 0.4007
Echinococcus granulosus microtubule associated protein 2 0.1394 0.7403 0.7403
Plasmodium vivax unspecified product 0.018 0.0858 0.2516
Brugia malayi cathepsin L-like cysteine proteinase 0.0154 0.0717 0.0717
Trypanosoma cruzi major cysteine proteinase, putative 0.0249 0.1229 0.1229
Entamoeba histolytica cysteine proteinase, putative 0.0333 0.1686 0.5427
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Loa Loa (eye worm) calpain family protein 1 0.1275 0.6761 0.6761
Brugia malayi fibroinase precursor 0.0154 0.0717 0.0717
Echinococcus granulosus calpain 5 0.0653 0.341 0.341
Entamoeba histolytica hypothetical protein 0.0039 0.0098 0.0315
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0098 0.0098
Giardia lamblia Cathepsin L precursor 0.0154 0.0717 0.1999
Echinococcus multilocularis calbindin 32 0.0113 0.0501 0.0501
Schistosoma mansoni neuronal calcium sensor 0.0111 0.0488 0.0488
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0196 0.0948 0.0948
Entamoeba histolytica cysteine proteinase, putative 0.0333 0.1686 0.5427
Leishmania major programmed cell death 6 protein-like protein 0.0111 0.0488 0.0681
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0653 0.341 0.476
Plasmodium falciparum serine repeat antigen 5 0.0154 0.0717 0.2308
Schistosoma mansoni cathepsin s 0.018 0.0858 0.0858
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Echinococcus granulosus cathepsin l1 0.0417 0.2138 0.2138
Schistosoma mansoni cpg binding protein 0.003 0.0051 0.0051
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0154 0.0717 0.1999
Loa Loa (eye worm) hypothetical protein 0.018 0.0858 0.0858
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0488 0.136
Onchocerca volvulus Cathepsin L homolog 0.0597 0.3106 0.4328
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Brugia malayi calpain 5 0.0196 0.0948 0.0948
Leishmania major cathepsin L-like protease 0.0597 0.3106 0.4336
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0166 0.0784 0.2523
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0196 0.0948 0.0948
Plasmodium vivax SET domain protein, putative 0.0061 0.0216 0.0633
Brugia malayi hypothetical protein 0.0039 0.0098 0.0098
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.06 0.3124 0.3124
Leishmania major oligopeptidase b 0.0553 0.2871 0.4007
Onchocerca volvulus 0.0061 0.0216 0.0287
Trypanosoma brucei calmodulin, putative 0.0113 0.0501 0.0699
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0031
Schistosoma mansoni caspase-3 (C14 family) 0.1267 0.6719 0.6719
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0154 0.0717 0.2308
Schistosoma mansoni hypothetical protein 0.0111 0.0488 0.0488
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Schistosoma mansoni caspase-7 (C14 family) 0.1267 0.6719 0.6719
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0098 0.0098
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Echinococcus multilocularis glycoprotein Antigen 5 0.0077 0.0303 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0597 0.3106 0.3106
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0098 0.0098
Trypanosoma cruzi metacaspase, putative 0.0539 0.2793 0.2793
Echinococcus granulosus apoptotic protease activating factor 1 0.0394 0.2011 0.2011
Brugia malayi calpain 5 0.0457 0.2352 0.2352
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0488 0.0681
Brugia malayi Cytochrome P450 family protein 0.0053 0.0174 0.0174
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.04 0.04
Onchocerca volvulus 0.0077 0.0303 0.0408
Trypanosoma cruzi metacaspase 5, putative 0.0539 0.2793 0.2793
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.1267 0.6719 0.6719
Schistosoma mansoni microtubule-associated protein tau 0.1394 0.7403 0.7403
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0102 0.0102
Loa Loa (eye worm) fibroinase 0.0597 0.3106 0.3106
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0154 0.0717 0.0717
Brugia malayi Protein kinase domain containing protein 0.0023 0.0011 0.0011
Toxoplasma gondii calcium-dependent protein kinase 0.0113 0.0501 0.0699
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0373 0.19 0.19
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0225 0.0225
Entamoeba histolytica cysteine protease, putative 0.0597 0.3106 1
Toxoplasma gondii cathepsin B 0.0686 0.3588 0.5008
Trypanosoma brucei I/6 autoantigen 0.0111 0.0488 0.0681
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Trichomonas vaginalis conserved hypothetical protein 0.0539 0.2793 0.7785
Loa Loa (eye worm) hypothetical protein 0.0166 0.0784 0.0784
Trypanosoma cruzi cysteine proteinase, putative 0.0333 0.1686 0.1686
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0373 0.19 0.19
Trichomonas vaginalis conserved hypothetical protein 0.0539 0.2793 0.7785
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.0717 0.1999
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0019 0.0062
Onchocerca volvulus 0.0095 0.04 0.0545
Schistosoma mansoni hypothetical protein 0.0077 0.0303 0.0303
Brugia malayi Trypsin family protein 0.0077 0.0303 0.0303
Trypanosoma cruzi cruzipain precursor, putative 0.018 0.0858 0.0858
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0098 0.0098
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0064 0.0232 0.0232
Schistosoma mansoni cathepsin F (C01 family) 0.0597 0.3106 0.3106
Plasmodium falciparum serine repeat antigen 2 0.0154 0.0717 0.2308
Echinococcus granulosus cpg binding protein 0.003 0.0051 0.0051
Brugia malayi Papain family cysteine protease containing protein 0.0333 0.1686 0.1686
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0597 0.3106 0.8658
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0098 0.0098
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0011 0.0034
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0077 0.0303 0.0303
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1732 0.9223 0.9223
Entamoeba histolytica calcium binding family protein 0.0111 0.0488 0.1571
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0082 0.0331 0.0331
Brugia malayi proteasome subunit beta type 1 0.0064 0.0232 0.0232
Onchocerca volvulus 0.0077 0.0303 0.0408
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0501 0.1468
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0154 0.0717 0.2308
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0154 0.0717 0.1999
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0023 0.0011 0.0015
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0539 0.2793 0.2793
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.0717 0.0717
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0082 0.0331 0.0922
Loa Loa (eye worm) programmed cell death protein 6 0.0113 0.0501 0.0501
Entamoeba histolytica cysteine protease, putative 0.0154 0.0717 0.2308
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0141 0.065 0.065
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Brugia malayi RNA, U transporter 1 0.0079 0.0317 0.0317
Onchocerca volvulus 0.0077 0.0303 0.0408
Trypanosoma brucei metacaspase 5, putative 0.0539 0.2793 0.3899
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0166 0.0784 0.0784
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0254 0.126 0.126
Loa Loa (eye worm) calpain 0.0653 0.341 0.341
Plasmodium vivax unspecified product 0.0333 0.1686 0.4943
Loa Loa (eye worm) hypothetical protein 0.0077 0.0303 0.0303
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0273
Loa Loa (eye worm) hypothetical protein 0.0117 0.0518 0.0518
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0111 0.0488 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0154 0.0717 0.1999
Leishmania major centrin, putative 0.0111 0.0488 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0686 0.3588 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0483 0.2491 0.3467
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Loa Loa (eye worm) hypothetical protein 0.0153 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0154 0.0717 0.0717
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0553 0.2871 1
Giardia lamblia Cathepsin L precursor 0.0154 0.0717 0.1999
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0082 0.0331 0.0331
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0113 0.0501 0.0501
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Echinococcus multilocularis calumenin 0.0113 0.0501 0.0501
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0495 0.0495
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0547 0.0547
Trypanosoma brucei Calpain-like protein 1.1 0.0196 0.0948 0.1323
Loa Loa (eye worm) hypothetical protein 0.0539 0.2793 0.2793
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Trypanosoma brucei centrin, putative 0.0111 0.0488 0.0681
Trypanosoma brucei metacaspase 0.0539 0.2793 0.3899
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0111 0.0488 0.0488
Plasmodium falciparum cysteine proteinase falcipain 1 0.0333 0.1686 0.5427
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0011 0.0011
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0011 0.0031
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0064 0.0232 0.0324
Loa Loa (eye worm) hypothetical protein 0.0417 0.2138 0.2138
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.4111 0.4111
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0139 0.0139
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0111 0.0488 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0417 0.2138 0.5958
Trypanosoma brucei centrin-3 0.0111 0.0488 0.0681
Echinococcus multilocularis expressed protein 0.0754 0.3953 0.3953
Brugia malayi proteasome subunit beta type 2 0.0039 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1686 0.4698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.0717 0.1999
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Echinococcus multilocularis cathepsin L 0.0154 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0394 0.2011 0.2011
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0166 0.0784 0.2523
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0333 0.1686 0.1686
Giardia lamblia Encystation-specific protease 0.0154 0.0717 0.1999
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.2396 0.2396
Loa Loa (eye worm) hypothetical protein 0.1275 0.6761 0.6761
Schistosoma mansoni hypothetical protein 0.0077 0.0303 0.0303
Giardia lamblia Cathepsin B precursor 0.0154 0.0717 0.1999
Trypanosoma brucei prolyl endopeptidase 0.135 0.7164 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0098 0.0098
Brugia malayi Pre-SET motif family protein 0.0061 0.0216 0.0216
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1876 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0333 0.1686 0.1686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0216 0.0216
Trypanosoma brucei metacaspase MCA2 0.0539 0.2793 0.3899
Schistosoma mansoni calmodulin 0.0111 0.0488 0.0488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.0717 0.1999
Brugia malayi calcium-binding protein 0.0111 0.0488 0.0488
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.0717 0.0717
Brugia malayi Angiotensin-converting enzyme family protein 0.06 0.3124 0.3124
Plasmodium vivax serine-repeat antigen (SERA) 0.0154 0.0717 0.2103
Echinococcus granulosus caspase 0.1267 0.6719 0.6719
Loa Loa (eye worm) papain family cysteine protease containing protein 0.018 0.0858 0.0858
Entamoeba histolytica grainin, putative 0.0113 0.0501 0.1612
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1184 0.627 1
Plasmodium vivax hypothetical protein, conserved 0.0539 0.2793 0.8191
Toxoplasma gondii calmodulin CAM1 0.0113 0.0501 0.0699
Echinococcus granulosus integrin beta 2 0.0226 0.1105 0.1105
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0011 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0333 0.1686 0.5427
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0019
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0082 0.0331 0.1065
Entamoeba histolytica hypothetical protein 0.0039 0.0098 0.0315
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.341
Plasmodium vivax unspecified product 0.0154 0.0717 0.2103
Echinococcus granulosus acylamino acid releasing enzyme 0.0166 0.0784 0.0784
Plasmodium falciparum serine repeat antigen 7 0.0154 0.0717 0.2308
Echinococcus granulosus cathepsin l1 0.0597 0.3106 0.3106
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0154 0.0717 0.1999
Brugia malayi Importin beta-1 subunit 0.0028 0.004 0.004
Echinococcus multilocularis cysteine protease 0.0597 0.3106 0.3106
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Brugia malayi cathepsin F-like cysteine proteinase 0.0154 0.0717 0.0717
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1843 0.9822 0.9822
Brugia malayi Trypsin family protein 0.0077 0.0303 0.0303
Schistosoma mansoni ef hand domain family member A2 0.0111 0.0488 0.0488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.0717 0.1999
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Echinococcus granulosus cathepsin L cysteine protease 0.0333 0.1686 0.1686
Onchocerca volvulus Cathepsin F homolog 0.0597 0.3106 0.4328
Echinococcus granulosus caspase 2 0.0933 0.4915 0.4915
Entamoeba histolytica cysteine proteinase, putative 0.0597 0.3106 1
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0011 0.0011
Echinococcus granulosus neuronal calcium sensor 0.0111 0.0488 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.0717 0.1999
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0064 0.0232 0.0324
Leishmania major calmodulin, putative 0.0111 0.0488 0.0681
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0098 0.0098
Trypanosoma brucei calmodulin, putative 0.0111 0.0488 0.0681
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0154 0.0717 0.0717
Loa Loa (eye worm) prolyl oligopeptidase 0.0166 0.0784 0.0784
Leishmania major hypothetical protein, unknown function 0.0196 0.0948 0.1323
Echinococcus multilocularis neurocalcin 0.0111 0.0488 0.0488
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0539 0.2793 0.7785
Leishmania major cathepsin L-like protease 0.0692 0.3619 0.5051
Plasmodium falciparum peptidase, putative 0.0166 0.0784 0.2523
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0046 0.0139 0.0139
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0154 0.0717 0.2103
Trichomonas vaginalis conserved hypothetical protein 0.0539 0.2793 0.7785
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0064 0.0232 0.0232
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Schistosoma mansoni hypothetical protein 0.0196 0.0948 0.0948
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0039 0.0102 0.0142
Leishmania major proteasome beta 2 subunit, putative 0.0039 0.0102 0.0142
Loa Loa (eye worm) EF hand family protein 0.0111 0.0488 0.0488
Schistosoma mansoni calpain C (C02 family) 0.0653 0.341 0.341
Loa Loa (eye worm) hypothetical protein 0.0112 0.0495 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Giardia lamblia Alanyl dipeptidyl peptidase 0.0166 0.0784 0.2185
Trypanosoma brucei antigen, putative 0.0653 0.341 0.476
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0077 0.0303 0.0303
Trichomonas vaginalis calcium binding protein, putative 0.0111 0.0488 0.136
Onchocerca volvulus Cathepsin L homolog 0.0597 0.3106 0.4328
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0019 0.0027
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0019 0.0019
Giardia lamblia Alanyl dipeptidyl peptidase 0.0166 0.0784 0.2185
Trypanosoma cruzi cysteine peptidase, putative 0.0692 0.3619 0.3619
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0553 0.2871 0.4007
Brugia malayi prolyl oligopeptidase family protein 0.0166 0.0784 0.0784
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0154 0.0717 0.1999
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1843 0.9822 0.9822
Plasmodium falciparum serine repeat antigen 9 0.0154 0.0717 0.2308
Entamoeba histolytica prolyl oligopeptidase family protein 0.0166 0.0784 0.2523
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0062 0.0062
Schistosoma mansoni neuronal calcium sensor 0.0111 0.0488 0.0488
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0019 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0098 0.0098
Brugia malayi Calmodulin-like protein 0.0111 0.0488 0.0488
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.135 0.7164 1
Trypanosoma brucei centrin, putative 0.0111 0.0488 0.0681
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Loa Loa (eye worm) hypothetical protein 0.0111 0.0488 0.0488
Schistosoma mansoni calmodulin 0.0111 0.0488 0.0488
Brugia malayi cathepsin L precursor 0.0154 0.0717 0.0717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Entamoeba histolytica cysteine proteinase, putative 0.0333 0.1686 0.5427
Leishmania major cathepsin L-like protease 0.0597 0.3106 0.4336
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0111 0.0488 0.136
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0019 0.0019
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.135 0.7164 0.7164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.341
Trypanosoma brucei kinesin, putative 0.0457 0.2352 0.3283
Trypanosoma cruzi 20S proteasome subunit 0.0039 0.0102 0.0102
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0404 0.2065 0.2065
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.018 0.0858 0.0858
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0111 0.0488 0.0488
Entamoeba histolytica prolyl oligopeptidase family protein 0.0166 0.0784 0.2523
Giardia lamblia Cathepsin B precursor 0.0686 0.3588 1
Echinococcus granulosus integrin alpha ps 0.0067 0.0248 0.0248
Echinococcus multilocularis caspase 8 0.0539 0.2793 0.2793
Plasmodium vivax vivapain-2 0.0597 0.3106 0.9109
Schistosoma mansoni hypothetical protein 0.0298 0.1495 0.1495
Brugia malayi cathepsin L-like precursor 0.0417 0.2138 0.2138
Echinococcus multilocularis enteropeptidase 0.0077 0.0303 0.0303
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0254 0.126 0.1759
Plasmodium falciparum calpain 0.0196 0.0948 0.3051
Schistosoma mansoni integrin alpha-ps 0.0035 0.0076 0.0076
Brugia malayi hypothetical protein 0.0153 0.0712 0.0712
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Brugia malayi calpain family protein 1 0.1732 0.9223 0.9223
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.0784 0.2185
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0154 0.0717 0.2308
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0547 0.1726
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0011 0.0011
Schistosoma mansoni integrin alpha 0.0149 0.069 0.069
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0064 0.0232 0.0232
Echinococcus granulosus tumor protein p63 0.0341 0.1729 0.1729
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0216 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0196 0.0948 0.2641
Schistosoma mansoni Mername-AA248 (C02 family) 0.0653 0.341 0.341
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0082 0.0331 0.0331
Brugia malayi hypothetical protein 0.0394 0.2011 0.2011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0154 0.0717 0.1999
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.476
Leishmania major importin beta-1 subunit, putative 0.0023 0.0011 0.0016
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0154 0.0717 0.2103
Leishmania major cathepsin L-like protease 0.0692 0.3619 0.5051
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0039 0.0102 0.0328
Echinococcus multilocularis integrin alpha ps 0.0032 0.0061 0.0061
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Echinococcus multilocularis calmodulin 0.0111 0.0488 0.0488
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0166 0.0784 0.1094
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Leishmania major metacaspase, putative 0.0539 0.2793 0.3899
Trypanosoma brucei Calpain-like protein CALP1.3 0.0196 0.0948 0.1323
Entamoeba histolytica grainin 2 0.0111 0.0488 0.1571
Plasmodium falciparum serine repeat antigen 6 0.0154 0.0717 0.2308
Entamoeba histolytica hypothetical protein, conserved 0.0166 0.0784 0.2523
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0254 0.126 0.126
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0417 0.2138 0.5958
Schistosoma mansoni calpain (C02 family) 0.0653 0.341 0.341
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0019 0.0027
Echinococcus multilocularis programmed cell death protein 0.0111 0.0488 0.0488
Entamoeba histolytica cysteine proteinase, putative 0.0597 0.3106 1
Entamoeba histolytica hypothetical protein 0.0023 0.0011 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.0858 0.0858
Plasmodium falciparum proteasome subunit beta type-5 0.0082 0.0331 0.1065
Trypanosoma cruzi cysteine peptidase, putative 0.0333 0.1686 0.1686
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0653 0.341 0.341
Echinococcus granulosus calpain 7 C02 family 0.0653 0.341 0.341
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.0717 0.1999
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0077 0.0303 0.0303
Echinococcus multilocularis caspase 0.1267 0.6719 0.6719
Onchocerca volvulus 0.0113 0.0501 0.0685
Echinococcus granulosus enteropeptidase 0.0077 0.0303 0.0303
Echinococcus granulosus programmed cell death protein 0.0111 0.0488 0.0488
Echinococcus granulosus EF HAND 1 calcium binding site 0.0111 0.0488 0.0488
Echinococcus granulosus integrin alpha ps 0.0032 0.0061 0.0061
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0154 0.0717 0.2308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0127 0.0127
Echinococcus multilocularis cathepsin L 0.0333 0.1686 0.1686
Plasmodium falciparum metacaspase-like protein 0.0539 0.2793 0.8992
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0098 0.0098
Echinococcus granulosus calpain A 0.0653 0.341 0.341
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0154 0.0717 0.0717
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0547 0.0763
Echinococcus multilocularis hypothetical protein 0.0653 0.341 0.341
Loa Loa (eye worm) ctsf protein 0.0597 0.3106 0.3106
Loa Loa (eye worm) prolyl oligopeptidase 0.0483 0.2491 0.2491
Trypanosoma brucei calpain, putative 0.0196 0.0948 0.1323
Echinococcus granulosus calpain 0.0653 0.341 0.341
Trypanosoma cruzi centrin-3 0.0111 0.0488 0.0488
Loa Loa (eye worm) proteasome subunit beta type 2 0.0039 0.0102 0.0102
Entamoeba histolytica cysteine proteinase 1, putative 0.0333 0.1686 0.5427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Trichomonas vaginalis conserved hypothetical protein 0.0539 0.2793 0.7785
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0098
Loa Loa (eye worm) integrin alpha pat-2 0.0229 0.1124 0.1124
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1495 0.1495
Loa Loa (eye worm) proteasome subunit beta type 1 0.0064 0.0232 0.0232
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0154 0.0717 0.1999
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0196 0.0948 0.2641
Echinococcus multilocularis neuronal calcium sensor 0.0111 0.0488 0.0488
Leishmania major calmodulin-like protein 0.0111 0.0488 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Brugia malayi Cathepsin L-like precursor 0.0597 0.3106 0.3106
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0201 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.0692 0.3619 0.3619
Giardia lamblia Cathepsin B precursor 0.0154 0.0717 0.1999
Brugia malayi Trypsin family protein 0.0077 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0141 0.065 0.065
Schistosoma mansoni integrin beta subunit 0.0179 0.0855 0.0855
Schistosoma mansoni cpg binding protein 0.0028 0.0042 0.0042
Trypanosoma cruzi I/6 autoantigen, putative 0.0111 0.0488 0.0488
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0064 0.0232 0.0748
Echinococcus granulosus caspase 8 0.0539 0.2793 0.2793
Trypanosoma brucei calpain, putative 0.0196 0.0948 0.1323
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.2396 0.2396
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1876 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0692 0.3619 0.3619
Schistosoma mansoni cathepsin S (C01 family) 0.0154 0.0717 0.0717
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0111 0.0488 0.1571
Entamoeba histolytica cysteine protease, putative 0.0154 0.0717 0.2308
Brugia malayi Pre-SET motif family protein 0.0419 0.2146 0.2146
Trypanosoma brucei Calpain-like protein 2 0.0196 0.0948 0.1323
Loa Loa (eye worm) hypothetical protein 0.0465 0.2396 0.2396
Plasmodium falciparum metacaspase 1 0.0539 0.2793 0.8992
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0019 0.0027
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0098 0.0098
Trichomonas vaginalis calcium binding protein, putative 0.0111 0.0488 0.136
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0064 0.0232 0.0748
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0019 0.0054
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0154 0.0717 0.2103
Echinococcus granulosus cathepsin b 0.1876 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0127
Entamoeba histolytica calpain large subunit domain III containing protein 0.0457 0.2352 0.757
Onchocerca volvulus 0.0477 0.2458 0.3421
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0254 0.126 0.1759
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Toxoplasma gondii hypothetical protein 0.0166 0.0784 0.1094
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0553 0.2871 0.4007
Loa Loa (eye worm) calpain 5 0.0457 0.2352 0.2352
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0154 0.0717 0.2103
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Giardia lamblia Cysteine protease 0.0154 0.0717 0.1999
Trypanosoma cruzi caltractin, putative 0.0111 0.0488 0.0488
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0653 0.341 0.341
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.1732 0.9223 0.9223
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Loa Loa (eye worm) calpain D 0.0196 0.0948 0.0948
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0098 0.0098
Toxoplasma gondii troponin c, isotype gamma, putative 0.0111 0.0488 0.0681
Mycobacterium ulcerans hypothetical protein 0.0077 0.0303 0.0857
Plasmodium vivax hypothetical protein, conserved 0.0166 0.0784 0.2299
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0098 0.0098
Toxoplasma gondii preprocathepsin c precursor, putative 0.0154 0.0717 0.1001
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0113 0.0501 0.0699
Echinococcus multilocularis calcium uptake protein 1 0.0113 0.0501 0.0501
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0019 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0273
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Schistosoma mansoni cpg binding protein 0.003 0.0051 0.0051
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0483 0.2491 0.2491
Echinococcus granulosus prolyl endopeptidase 0.135 0.7164 0.7164
Trypanosoma cruzi metacaspase, putative 0.0539 0.2793 0.2793
Echinococcus granulosus calcium uptake protein 1 0.0113 0.0501 0.0501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0127
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0154 0.0717 0.2103
Loa Loa (eye worm) hypothetical protein 0.0061 0.0216 0.0216
Plasmodium falciparum importin beta, putative 0.0028 0.004 0.0128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Trypanosoma cruzi metacaspase 5, putative 0.0539 0.2793 0.2793
Leishmania major cathepsin L-like protease 0.0692 0.3619 0.5051
Trypanosoma cruzi kinesin, putative 0.0457 0.2352 0.2352
Onchocerca volvulus 0.0597 0.3106 0.4328
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0061
Trypanosoma cruzi calmodulin, putative 0.0111 0.0488 0.0488
Brugia malayi hypothetical protein 0.0077 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.1876 1 1
Toxoplasma gondii cathepsin CPC1 0.0154 0.0717 0.1001
Entamoeba histolytica prolyl oligopeptidase family protein 0.0166 0.0784 0.2523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.0717 0.1999
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0553 0.2871 0.4562
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0098 0.0098
Trypanosoma brucei Calpain-like protein 1.2 0.0196 0.0948 0.1323
Giardia lamblia Cysteine protease 0.0154 0.0717 0.1999
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0019 0.5
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Loa Loa (eye worm) hypothetical protein 0.018 0.0858 0.0858
Plasmodium falciparum serine repeat antigen 3 0.0154 0.0717 0.2308
Loa Loa (eye worm) hypothetical protein 0.0088 0.0366 0.0366
Echinococcus granulosus glycoprotein Antigen 5 0.0077 0.0303 0.0303
Schistosoma mansoni calpain-7 (C02 family) 0.0653 0.341 0.341
Brugia malayi Cathepsin L-like precursor 0.0417 0.2138 0.2138
Schistosoma mansoni reticulocalbin 0.0111 0.0488 0.0488
Trypanosoma cruzi kinesin, putative 0.0457 0.2352 0.2352
Trypanosoma cruzi calmodulin, putative 0.0111 0.0488 0.0488
Leishmania major calpain family cysteine protease-like protein 0.0196 0.0948 0.1323
Brugia malayi Cytochrome P450 family protein 0.0032 0.0062 0.0062
Echinococcus multilocularis tumor protein p63 0.0341 0.1729 0.1729
Plasmodium falciparum cysteine proteinase falcipain 3 0.0597 0.3106 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0196 0.0948 0.2641
Trichomonas vaginalis calmodulin-2, putative 0.0111 0.0488 0.136
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0064 0.0232 0.0648
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0102 0.0102
Giardia lamblia Proteasome subunit beta type 1 0.0064 0.0232 0.0648
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0196 0.0948 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0273
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0196 0.0948 0.1323
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0653 0.341 0.341
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0039 0.0102 0.0328
Entamoeba histolytica cysteine proteinase 2 0.0333 0.1686 0.5427
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0273
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0154 0.0717 0.2103
Plasmodium vivax proteasome subunit beta type-5, putative 0.0082 0.0331 0.097
Leishmania major cathepsin L-like protease 0.0597 0.3106 0.4336
Onchocerca volvulus 0.0597 0.3106 0.4328
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Plasmodium vivax vivapain-3 0.0333 0.1686 0.4943
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0653 0.341 0.341
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Trichomonas vaginalis calcium binding protein, putative 0.0111 0.0488 0.136
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0547 0.0547
Mycobacterium tuberculosis Probable peptidase 0.0553 0.2871 0.4562
Loa Loa (eye worm) hypothetical protein 0.0077 0.0303 0.0303
Leishmania major i/6 autoantigen-like protein 0.0111 0.0488 0.0681
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0111 0.0488 0.0488
Echinococcus multilocularis cpg binding protein 0.003 0.0051 0.0051
Onchocerca volvulus 0.0597 0.3106 0.4328
Loa Loa (eye worm) hypothetical protein 0.0082 0.0331 0.0331
Loa Loa (eye worm) trypsin family protein 0.0077 0.0303 0.0303
Brugia malayi hypothetical protein 0.0046 0.0139 0.0139
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0547 0.0547
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0547 0.1726
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1876 1 1
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0333 0.1686 0.1686
Trypanosoma brucei hypothetical protein 0.0196 0.0948 0.1323
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Toxoplasma gondii cathepsin CPC2 0.0154 0.0717 0.1001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0098
Trypanosoma cruzi metacaspase, putative 0.0539 0.2793 0.2793
Onchocerca volvulus 0.0153 0.0712 0.098
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0098 0.0098
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Trypanosoma brucei proteasome beta 6 subunit 0.0064 0.0232 0.0324
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Giardia lamblia Cathepsin B precursor 0.0154 0.0717 0.1999
Schistosoma mansoni calmodulin related calcium binding protein 0.0111 0.0488 0.0488
Trypanosoma brucei cysteine peptidase C (CPC) 0.0686 0.3588 0.5008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0098 0.0098
Echinococcus granulosus cysteine protease 0.0333 0.1686 0.1686
Echinococcus granulosus EF hand domain containing family member A2 0.0111 0.0488 0.0488
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Loa Loa (eye worm) DEAH box polypeptide 35 0.0065 0.0239 0.0239
Leishmania major cathepsin L-like protease 0.0597 0.3106 0.4336
Giardia lamblia Cathepsin L-like protease 0.0154 0.0717 0.1999
Brugia malayi Probable ATP-dependent helicase DHX35 0.0065 0.0239 0.0239
Giardia lamblia Cathepsin L precursor 0.0154 0.0717 0.1999
Echinococcus granulosus importin subunit beta 1 0.0028 0.004 0.004
Echinococcus multilocularis caspase 2 0.0933 0.4915 0.4915
Loa Loa (eye worm) hypothetical protein 0.0141 0.065 0.065
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0098 0.0098
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0077 0.0303 0.0303
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.004 0.0055
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0196 0.0948 0.2641
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0077 0.0303 0.0303
Brugia malayi Papain family cysteine protease containing protein 0.0597 0.3106 0.3106
Trichomonas vaginalis calcium binding proteins, putative 0.0111 0.0488 0.136
Brugia malayi calpain D 0.0196 0.0948 0.0948
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Leishmania major hypothetical protein, conserved 0.0196 0.0948 0.1323
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0039 0.0102 0.0142
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1876 1 1
Toxoplasma gondii hypothetical protein 0.0196 0.0948 0.1323
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0082 0.0331 0.0922
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0512 0.265 0.265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Trypanosoma brucei metacaspase MCA3 0.0539 0.2793 0.3899
Trichomonas vaginalis calcineurin B subunit, putative 0.0111 0.0488 0.136
Trypanosoma cruzi cysteine protease, putative 0.0333 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.1079 0.5702 0.5702
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0488 0.136
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.004 0.0055
Trichomonas vaginalis calpain, putative 0.0196 0.0948 0.2641
Echinococcus multilocularis microtubule associated protein 2 0.1394 0.7403 0.7403
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0082 0.0331 0.0498
Onchocerca volvulus 0.0111 0.0488 0.0667
Onchocerca volvulus Deterin homolog 0.0141 0.065 0.0894
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0539 0.2793 0.3899
Brugia malayi Cathepsin L-like precursor 0.0417 0.2138 0.2138
Loa Loa (eye worm) hypothetical protein 0.0417 0.2138 0.2138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0333 0.1686 0.2353
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0254 0.126 0.126
Brugia malayi Kelch motif family protein 0.0046 0.0139 0.0139
Schistosoma mansoni reticulocalbin 0.0113 0.0501 0.0501
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0064 0.0232 0.0232
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0154 0.0717 0.2103
Echinococcus multilocularis integrin alpha ps 0.0067 0.0248 0.0248
Toxoplasma gondii EFHC1, putative 0.0111 0.0488 0.0681
Echinococcus multilocularis calmodulin 0.0111 0.0488 0.0488
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0196 0.0948 0.1323
Giardia lamblia Cathepsin L precursor 0.0154 0.0717 0.1999
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0196 0.0948 0.0948
Giardia lamblia Cathepsin B precursor 0.0686 0.3588 1
Leishmania major calpain protease-like protein 0.0196 0.0948 0.1323
Brugia malayi hypothetical protein 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0154 0.0717 0.1999
Echinococcus granulosus calmodulin 0.0111 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.018 0.0858 0.0858
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0141 0.065 0.065
Onchocerca volvulus 0.0394 0.2011 0.2797
Schistosoma mansoni calpain-7 (C02 family) 0.0653 0.341 0.341
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0098 0.0098
Leishmania major cysteine peptidase A (CPA) 0.0597 0.3106 0.4336
Brugia malayi cathepsin F-like cysteine proteinase 0.018 0.0858 0.0858
Plasmodium vivax metacaspase 1, putative 0.0539 0.2793 0.8191
Trypanosoma cruzi cruzipain precursor, putative 0.0692 0.3619 0.3619
Plasmodium vivax proteasome subunit beta type-1, putative 0.0064 0.0232 0.0681
Trichomonas vaginalis centrin, putative 0.0111 0.0488 0.136
Onchocerca volvulus 0.0597 0.3106 0.4328
Entamoeba histolytica protein kinase, putative 0.0457 0.2352 0.757
Schistosoma mansoni neuronal calcium sensor 0.0111 0.0488 0.0488
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0141 0.065 0.065
Brugia malayi Cell death protein 3 precursor 0.0933 0.4915 0.4915
Loa Loa (eye worm) hypothetical protein 0.0077 0.0303 0.0303
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0154 0.0717 0.0717
Plasmodium vivax centrin-1, putative 0.0111 0.0488 0.1431
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0154 0.0717 0.1999
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0039 0.0102 0.0102
Entamoeba histolytica calmodulin, putative 0.0111 0.0488 0.1571
Loa Loa (eye worm) hypothetical protein 0.0154 0.0717 0.0717
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.004 0.0055
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0062 0.0062
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.135 0.7164 0.7164
Echinococcus granulosus transmembrane protease serine 3 0.0077 0.0303 0.0303
Trypanosoma brucei Metacaspase-4 0.0539 0.2793 0.3899
Echinococcus granulosus cathepsin L 0.0154 0.0717 0.0717
Schistosoma mansoni cathepsin F (C01 family) 0.0597 0.3106 0.3106
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0154 0.0717 0.2308
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1843 0.9822 0.9822
Entamoeba histolytica calpain family cysteine protease, putative 0.0196 0.0948 0.3051
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0102 0.0284
Leishmania major protein kinase, putative 0.0111 0.0488 0.0681
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0216 0.0301
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0686 0.3588 0.5008
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0111 0.0488 0.0488
Echinococcus multilocularis EF hand domain containing family member A2 0.0111 0.0488 0.0488
Schistosoma mansoni cathepsin C 0.0154 0.0717 0.0717
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0098 0.0098
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0196 0.0948 0.1323
Loa Loa (eye worm) integrin beta-2 0.0304 0.153 0.153
Trichomonas vaginalis set domain proteins, putative 0.0476 0.2457 0.6847
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0098 0.0273
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0019 0.0019
Echinococcus multilocularis calpain 5 0.0653 0.341 0.341
Brugia malayi prolyl oligopeptidase family protein 0.0166 0.0784 0.0784
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0191 0.0266
Loa Loa (eye worm) hypothetical protein 0.0077 0.0303 0.0303
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0154 0.0717 0.2103
Loa Loa (eye worm) cysteine protease 0.0597 0.3106 0.3106
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0196 0.0948 0.0948
Leishmania major proteasome beta 5 subunit, putative 0.0082 0.0331 0.0462
Loa Loa (eye worm) hypothetical protein 0.0077 0.0303 0.0303
Giardia lamblia Cysteine protease 0.0154 0.0717 0.1999
Plasmodium falciparum serine repeat antigen 8 0.0154 0.0717 0.2308
Echinococcus multilocularis integrin alpha 3 0.0114 0.0503 0.0503
Echinococcus granulosus centrin 2 0.0111 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0154 0.0717 0.0717
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0483 0.2491 0.2491
Giardia lamblia Cathepsin B precursor 0.0154 0.0717 0.1999
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0417 0.2138 0.2138
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2065 0.2065
Echinococcus granulosus calumenin 0.0113 0.0501 0.0501
Brugia malayi Trypsin family protein 0.0077 0.0303 0.0303
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Schistosoma mansoni hypothetical protein 0.0095 0.04 0.04
Brugia malayi Papain family cysteine protease containing protein 0.0154 0.0717 0.0717
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.1267 0.6719 0.6719
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0653 0.341 0.341
Schistosoma mansoni centrin 0.0111 0.0488 0.0488
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0019 0.0054
Echinococcus granulosus cathepsin b 0.1876 1 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0019 0.0054
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0653 0.341 0.341
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Echinococcus multilocularis acylamino acid releasing enzyme 0.0166 0.0784 0.0784
Echinococcus multilocularis proteasome (prosome, macropain) 0.0082 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0077 0.0303 0.0303
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0196 0.0948 0.0948
Schistosoma mansoni hypothetical protein 0.0394 0.2011 0.2011
Loa Loa (eye worm) hypothetical protein 0.1536 0.8165 0.8165
Brugia malayi Integrin alpha pat-2 precursor 0.0149 0.069 0.069
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0373 0.19 0.19
Plasmodium vivax serine-repeat antigen (SERA) 0.0154 0.0717 0.2103
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0539 0.2793 0.2793
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0216 0.0216
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0111 0.0488 0.136
Echinococcus multilocularis apoptotic protease activating factor 1 0.0394 0.2011 0.2011
Toxoplasma gondii cathepsin CPL 0.0597 0.3106 0.4336
Trichomonas vaginalis myosin light chain 1, putative 0.0111 0.0488 0.136
Trichomonas vaginalis calpain, putative 0.0196 0.0948 0.2641
Loa Loa (eye worm) cathepsin B 0.0686 0.3588 0.3588
Leishmania major calmodulin-like protein 0.0111 0.0488 0.0681
Mycobacterium ulcerans proteasome PrcB 0.0082 0.0331 0.0958
Schistosoma mansoni hypothetical protein 0.0141 0.065 0.065
Schistosoma mansoni memapsin-2 (A01 family) 0.0426 0.2184 0.2184
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0154 0.0717 0.1999
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0111 0.0488 0.0488
Echinococcus multilocularis integrin alpha ps 0.0067 0.0248 0.0248
Onchocerca volvulus 0.0111 0.0488 0.0667
Leishmania major kinesin, putative 0.0457 0.2352 0.3283
Schistosoma mansoni cathepsin F (C01 family) 0.0417 0.2138 0.2138
Brugia malayi Cathepsin L-like precursor 0.018 0.0858 0.0858
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0111 0.0488 0.0488
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0196 0.0948 0.0948
Echinococcus granulosus inhibitor of apoptosis protein 0.0141 0.065 0.065
Echinococcus multilocularis integrin beta 2 0.0226 0.1105 0.1105
Giardia lamblia Hypothetical protein 0.0154 0.0717 0.1999
Brugia malayi Papain family cysteine protease containing protein 0.0154 0.0717 0.0717
Brugia malayi calpain 7 0.0653 0.341 0.341
Echinococcus multilocularis calpain 0.0653 0.341 0.341
Entamoeba histolytica calmodulin, putative 0.0111 0.0488 0.1571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Loa Loa (eye worm) calpain family protein 1 0.1732 0.9223 0.9223
Trichomonas vaginalis calmodulin, putative 0.0111 0.0488 0.136
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0686 0.3588 0.3588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.0717 0.1999
Schistosoma mansoni centrin-related 0.0111 0.0488 0.0488
Trichomonas vaginalis calcium binding protein, putative 0.0111 0.0488 0.136
Echinococcus granulosus cathepsin L cysteine proteinase 0.0597 0.3106 0.3106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.341
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0098 0.0098
Trypanosoma cruzi oligopeptidase b 0.0553 0.2871 0.2871
Echinococcus granulosus EF hand domain containing family member A2 0.0113 0.0501 0.0501
Plasmodium vivax proteasome subunit beta type-2, putative 0.0039 0.0102 0.0299
Plasmodium falciparum centrin-1 0.0111 0.0488 0.1571
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.004
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0254 0.126 0.126
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Giardia lamblia Proteasome subunit beta type 2 0.0039 0.0102 0.0284
Brugia malayi prolyl oligopeptidase family protein 0.0483 0.2491 0.2491
Schistosoma mansoni mitochondrial solute carrier 0.0111 0.0488 0.0488
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0159 0.0159
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.2146 0.2146
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0019 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0254 0.126 0.1759
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0174 0.0174
Plasmodium vivax vivapain-1 0.0333 0.1686 0.4943
Echinococcus granulosus cathepsin l cysteine peptidase 0.0597 0.3106 0.3106
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0196 0.0948 0.0948
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Loa Loa (eye worm) hypothetical protein 0.0154 0.0717 0.0717
Toxoplasma gondii proteasome subunit beta type, putative 0.0082 0.0331 0.0462
Brugia malayi Cathepsin L-like precursor 0.0597 0.3106 0.3106
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0154 0.0717 0.0717
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0483 0.2491 0.2491
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0166 0.0784 0.1094
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Trypanosoma brucei calpain-like protein, putative 0.0653 0.341 0.476
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.0717 0.1999
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0166 0.0784 0.2185
Schistosoma mansoni cathepsin B (C01 family) 0.0154 0.0717 0.0717
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0333 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0076
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0098 0.0098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.0717 0.0717
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0539 0.2793 0.3899
Loa Loa (eye worm) hypothetical protein 0.0111 0.0488 0.0488
Brugia malayi Kringle domain containing protein 0.0023 0.0011 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2065 0.2065
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0011 0.0031
Echinococcus multilocularis centrin 2 0.0111 0.0488 0.0488
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0154 0.0717 0.2308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Trypanosoma brucei cysteine peptidase, putative 0.0196 0.0948 0.1323
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0102 0.0284
Echinococcus granulosus neurocalcin 0.0111 0.0488 0.0488
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Echinococcus multilocularis calpain family protein 1, d 0.1275 0.6761 0.6761
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0597 0.3106 1
Brugia malayi hypothetical protein 0.0088 0.0366 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0154 0.0717 0.2308
Trypanosoma brucei calpain-like protein, putative 0.0653 0.341 0.476
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0127 0.0127
Echinococcus granulosus calbindin 32 0.0113 0.0501 0.0501
Brugia malayi Cytochrome P450 family protein 0.0032 0.0062 0.0062
Giardia lamblia Cathepsin L-like protease 0.0154 0.0717 0.1999
Loa Loa (eye worm) calmodulin-like protein 0.0111 0.0488 0.0488
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0098 0.0098
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0166 0.0784 0.0784
Onchocerca volvulus 0.0028 0.0042 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0127 0.0127
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0098 0.0098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.0717 0.0717
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0111 0.0488 0.1431
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0111 0.0488 0.0488
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0098 0.0098
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Onchocerca volvulus 0.0417 0.2138 0.2974
Leishmania major cytochrome p450-like protein 0.0032 0.0062 0.0086
Onchocerca volvulus 0.1079 0.5702 0.7956
Entamoeba histolytica cysteine protease, putative 0.0333 0.1686 0.5427
Schistosoma mansoni caspase-7 (C14 family) 0.0933 0.4915 0.4915
Entamoeba histolytica hypothetical protein 0.0154 0.0717 0.2308
Brugia malayi Cathepsin L-like cysteine proteinase 0.0417 0.2138 0.2138
Brugia malayi PXA domain containing protein 0.0039 0.0098 0.0098
Echinococcus multilocularis caspase 3 0.0728 0.3815 0.3815
Echinococcus multilocularis cysteine protease 0.0597 0.3106 0.3106
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0154 0.0717 0.0717
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0597 0.3106 0.3106
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0166 0.0784 0.2185
Brugia malayi prolyl oligopeptidase family protein 0.0254 0.126 0.126
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0154 0.0717 0.2103
Echinococcus granulosus caspase 3 0.0728 0.3815 0.3815
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Trypanosoma brucei mitochondrial calcium uptake 1 0.0111 0.0488 0.0681
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0098 0.0098
Schistosoma mansoni neuronal calcium sensor 0.0111 0.0488 0.0488
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0019 0.0062
Leishmania major centrin, putative 0.0111 0.0488 0.0681
Brugia malayi calpain family protein 1 0.1732 0.9223 0.9223
Brugia malayi Cathepsin L-like precursor 0.0597 0.3106 0.3106
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.476
Onchocerca volvulus 0.0597 0.3106 0.4328
Toxoplasma gondii centrin, putative 0.0111 0.0488 0.0681
Trypanosoma cruzi calmodulin, putative 0.0111 0.0488 0.0488
Giardia lamblia Hypothetical protein 0.0113 0.0501 0.1395
Brugia malayi Trypsin-like protease protein 5 0.0077 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0597 0.3106 0.3106
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0539 0.2793 0.3899
Schistosoma mansoni survival motor neuron protein 0.0095 0.04 0.04
Onchocerca volvulus 0.0597 0.3106 0.4328
Echinococcus multilocularis EF hand domain containing family member A2 0.0113 0.0501 0.0501
Giardia lamblia Cathepsin L precursor 0.0154 0.0717 0.1999
Trypanosoma cruzi conserved protein 0.0196 0.0948 0.0948
Trichomonas vaginalis hypothetical protein 0.0196 0.0948 0.2641
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0098
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0539 0.2793 0.7785
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0154 0.0717 0.0717
Brugia malayi EF hand family protein 0.0113 0.0501 0.0501
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0098 0.0098
Trichomonas vaginalis calpain, putative 0.0196 0.0948 0.2641
Trypanosoma brucei Component of motile flagella 41 0.0111 0.0488 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0597 0.3106 0.8658
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1876 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0166 0.0784 0.0784
Trypanosoma brucei calpain-like protein, putative 0.0653 0.341 0.476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0333 0.1686 0.2353
Giardia lamblia Hypothetical protein 0.0154 0.0717 0.1999
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0254 0.126 0.1759
Loa Loa (eye worm) hypothetical protein 0.005 0.0159 0.0159
Onchocerca volvulus 0.0077 0.0303 0.0408
Brugia malayi PXA domain containing protein 0.0039 0.0098 0.0098
Leishmania major cathepsin L-like protease 0.0597 0.3106 0.4336
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0547 0.1726
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0098 0.0098
Trichomonas vaginalis centrin, putative 0.0111 0.0488 0.136
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Brugia malayi prolyl oligopeptidase family protein 0.135 0.7164 0.7164
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.476
Brugia malayi programmed cell death protein 6 0.0111 0.0488 0.0488
Schistosoma mansoni importin beta-1 0.0028 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0062 0.0086
Brugia malayi Proteasome A-type and B-type family protein 0.0082 0.0331 0.0331
Brugia malayi cathepsin Z-like cysteine proteinase 0.0154 0.0717 0.0717
Echinococcus granulosus Dipeptidyl peptidase 9 0.0254 0.126 0.126
Onchocerca volvulus Cathepsin L homolog 0.0154 0.0717 0.0988
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0686 0.3588 0.3588
Entamoeba histolytica hypothetical protein, conserved 0.0113 0.0501 0.1612
Giardia lamblia Cysteine protease 0.0154 0.0717 0.1999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0692 0.3619 0.5051
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.0717 0.0717
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0111 0.0488 0.0488
Echinococcus granulosus cathepsin L 0.0333 0.1686 0.1686
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0154 0.0717 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.0948 0.2641
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0019 0.0027
Brugia malayi Cathepsin L-like precursor 0.0597 0.3106 0.3106
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Onchocerca volvulus 0.0154 0.0717 0.0988
Onchocerca volvulus 0.005 0.0159 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0127 0.0127
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0098 0.0098
Trypanosoma brucei calpain-like protein, putative 0.0653 0.341 0.476
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0154 0.0717 0.1999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0154 0.0717 0.1999
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0196 0.0948 0.1323
Loa Loa (eye worm) hypothetical protein 0.0065 0.0239 0.0239
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0547 0.0843
Onchocerca volvulus 0.0077 0.0303 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0539 0.2793 0.7785
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0111 0.0488 0.1571
Echinococcus multilocularis importin subunit beta 1 0.0028 0.004 0.004
Echinococcus multilocularis programmed cell death protein 0.0111 0.0488 0.0488
Trypanosoma brucei oligopeptidase b 0.0553 0.2871 0.4007
Entamoeba histolytica cysteine proteinase, putative 0.0417 0.2138 0.6882
Echinococcus multilocularis cathepsin L cysteine protease 0.0597 0.3106 0.3106
Brugia malayi hypothetical protein 0.0465 0.2396 0.2396
Giardia lamblia Cathepsin B precursor 0.0154 0.0717 0.1999
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0039 0.0102 0.0102
Echinococcus multilocularis cathepsin L cysteine protease 0.0597 0.3106 0.3106
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0553 0.2871 0.2871
Schistosoma mansoni cercarial elastase (S01 family) 0.0077 0.0303 0.0303
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0333 0.1686 0.1686
Leishmania major hypothetical protein, conserved 0.0111 0.0488 0.0681
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0196 0.0948 0.0948
Echinococcus granulosus integrin alpha 3 0.0114 0.0503 0.0503
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0062 0.0062
Entamoeba histolytica cysteine protease, putative 0.0154 0.0717 0.2308
Trichomonas vaginalis calcineurin B subunit, putative 0.0113 0.0501 0.1395
Trypanosoma brucei protein I/6 0.0111 0.0488 0.0681
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0098 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0141 0.065 0.065
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Leishmania major calmodulin, putative 0.0111 0.0488 0.0681
Trypanosoma cruzi metacaspase, putative 0.0539 0.2793 0.2793
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0597 0.3106 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0216 0.0216
Echinococcus multilocularis snurportin 1 0.0298 0.1495 0.1495
Onchocerca volvulus 0.0597 0.3106 0.4328
Brugia malayi CXXC zinc finger family protein 0.0028 0.0042 0.0042
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0019 0.0019
Brugia malayi Papain family cysteine protease containing protein 0.0154 0.0717 0.0717
Entamoeba histolytica cysteine protease, putative 0.0154 0.0717 0.2308
Toxoplasma gondii prolyl endopeptidase 0.135 0.7164 1
Echinococcus multilocularis Mastin 0.0077 0.0303 0.0303
Echinococcus multilocularis cathepsin b 0.1876 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0196 0.0948 0.0948
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0032 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.3106 0.8658
Toxoplasma gondii EF hand domain-containing protein 0.0111 0.0488 0.0681
Loa Loa (eye worm) hypothetical protein 0.0933 0.4915 0.4915
Onchocerca volvulus Prolyl endopeptidase homolog 0.135 0.7164 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0127 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1686 0.4698
Echinococcus granulosus snurportin 1 0.0298 0.1495 0.1495
Echinococcus granulosus calpain A 0.1845 0.9834 0.9834
Brugia malayi cathepsin Z-like cysteine proteinase 0.0154 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0154 0.0717 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0166 0.0784 0.0784
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0082 0.0331 0.0331
Plasmodium falciparum serine repeat antigen 1 0.0154 0.0717 0.2308
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0196 0.0948 0.1323
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0062 0.0062
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0039 0.0102 0.0102
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0111 0.0488 0.0488
Trichomonas vaginalis calmodulin, putative 0.0113 0.0501 0.1395
Schistosoma mansoni rab 0.0111 0.0488 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0273
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0196 0.0948 0.2641
Trypanosoma brucei caltractin, putative 0.0111 0.0488 0.0681
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0098 0.0098
Plasmodium vivax calpain, putative 0.0653 0.341 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0154 0.0717 0.0717
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0553 0.2871 1
Echinococcus multilocularis calpain A 0.1845 0.9834 0.9834
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0064 0.0232 0.0232
Echinococcus granulosus expressed protein 0.0754 0.3953 0.3953
Entamoeba histolytica hypothetical protein 0.0039 0.0098 0.0315
Loa Loa (eye worm) hypothetical protein 0.135 0.7164 0.7164
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0154 0.0717 0.0717
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.3106 0.3106
Brugia malayi EF hand family protein 0.0111 0.0488 0.0488
Leishmania major centrin, putative,caltractin, putative 0.0111 0.0488 0.0681
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0098 0.0098
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0154 0.0717 0.1999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0141 0.065 0.065
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0547 0.0763
Schistosoma mansoni calpain-2 (C02 family) 0.0196 0.0948 0.0948
Entamoeba histolytica calcium-binding protein, putative 0.0111 0.0488 0.1571
Toxoplasma gondii centrin 0.0111 0.0488 0.0681
Plasmodium vivax vivapain-2 0.0597 0.3106 0.9109
Schistosoma mansoni inhibitor of apoptosis protein 0.0141 0.065 0.065
Leishmania major calcineurin B subunit, putative 0.0111 0.0488 0.0681
Echinococcus multilocularis inhibitor of apoptosis protein 0.0141 0.065 0.065
Brugia malayi Cathepsin L-like precursor 0.0597 0.3106 0.3106
Onchocerca volvulus Cell death protein 3 homolog 0.0933 0.4915 0.6856
Trypanosoma cruzi prolyl endopeptidase 0.135 0.7164 0.7164
Schistosoma mansoni integrin alpha-ps 0.0067 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0196 0.0948 0.2641
Echinococcus multilocularis cathepsin b 0.1876 1 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0553 0.2871 0.2871
Trypanosoma cruzi centrin, putative 0.0111 0.0488 0.0488
Plasmodium falciparum serine repeat antigen 4 0.0154 0.0717 0.2308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.3106 0.8658
Echinococcus multilocularis calpain 7 (C02 family) 0.0653 0.341 0.341
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0154 0.0717 0.2103
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0273
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0098 0.0098
Brugia malayi Integrin beta pat-3 precursor 0.0304 0.153 0.153
Echinococcus multilocularis prolyl endopeptidase 0.135 0.7164 0.7164
Echinococcus granulosus Mastin 0.0077 0.0303 0.0303
Giardia lamblia Cathepsin L precursor 0.0154 0.0717 0.1999
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0196 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0077 0.0303 0.0303
Giardia lamblia Cathepsin B precursor 0.0686 0.3588 1
Onchocerca volvulus 0.0077 0.0303 0.0408
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0111 0.0488 0.0488
Onchocerca volvulus 0.0141 0.065 0.0894
Brugia malayi Papain family cysteine protease containing protein 0.0333 0.1686 0.1686
Trypanosoma cruzi I/6 autoantigen, putative 0.0111 0.0488 0.0488
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0154 0.0717 0.1999
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0653 0.341 0.476
Loa Loa (eye worm) hypothetical protein 0.0166 0.0784 0.0784
Brugia malayi Cathepsin L-like precursor 0.0597 0.3106 0.3106
Echinococcus multilocularis transmembrane protease serine 3 0.0077 0.0303 0.0303
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0597 0.3106 0.3106
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0098
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0082 0.0331 0.0462
Trypanosoma cruzi centrin, putative 0.0111 0.0488 0.0488

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 20 % The compound at 1 microM was tested in vivo for inhibitory effect on 48-h homologous passive cutaneous anaphylaxis (PCA) in rats administered peroally ChEMBL. 1350797
Inhibition (binding) = 80 % Binding affinity for Muscarinic acetylcholine receptor M1 from rat striatum, using [3H]-quinuclidinyl benzilate as radioligand at 10 uM. ChEMBL. 1350797
Inhibition (binding) = 80 % Binding affinity for Muscarinic acetylcholine receptor M1 from rat striatum, using [3H]-quinuclidinyl benzilate as radioligand at 10 uM. ChEMBL. 1350797
Ki (binding) = 0.13 nM Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]-pyrilamine as radioligand at 0.1 microM. ChEMBL. 1350797
Ki (binding) = 0.13 nM Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]-pyrilamine as radioligand at 0.1 microM. ChEMBL. 1350797

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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