Detailed information for compound 325881

Basic information

Technical information
  • TDR Targets ID: 325881
  • Name: 4-(4-methylsulfonylphenyl)-3,6-diphenylpyran- 2-one
  • MW: 402.462 | Formula: C24H18O4S
  • H donors: 0 H acceptors: 3 LogP: 4.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1oc(cc(c1c1ccccc1)c1ccc(cc1)S(=O)(=O)C)c1ccccc1
  • InChi: 1S/C24H18O4S/c1-29(26,27)20-14-12-17(13-15-20)21-16-22(18-8-4-2-5-9-18)28-24(25)23(21)19-10-6-3-7-11-19/h2-16H,1H3
  • InChiKey: UECQDYSDNRXIAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(4-methylsulfonylphenyl)-3,6-diphenyl-pyran-2-one
  • 4-(4-methylsulfonylphenyl)-3,6-diphenyl-2-pyranone
  • 4-(4-mesylphenyl)-3,6-diphenyl-pyran-2-one
  • 4-(4-methylsulfonylphenyl)-3,6-di(phenyl)pyran-2-one
  • 4-(4-methylsulfonylphenyl)-3,6-di(phenyl)-2-pyranone
  • 4-(4-mesylphenyl)-3,6-di(phenyl)pyran-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Ovis aries Cyclooxygenase-2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Mastin 0.0059 0.0048 0.0048
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0179 0.0238 0.0238
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0017 0.0017
Schistosoma mansoni cathepsin s 0.0267 0.0376 0.0376
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0007 0.002
Brugia malayi hypothetical protein 0.0029 0.0002 0.0002
Brugia malayi calpain family protein 1 0.4655 0.7267 0.7267
Echinococcus granulosus cathepsin l1 0.0995 0.1519 0.1519
Trypanosoma cruzi kinesin, putative 0.1233 0.1892 0.1887
Brugia malayi cathepsin L-like precursor 0.0728 0.11 0.11
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0223 0.0306 0.0306
Onchocerca volvulus Cathepsin L homolog 0.0995 0.1519 0.3356
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0334 0.0481 0.1063
Plasmodium falciparum serine repeat antigen 3 0.0336 0.0485 0.319
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0032 0.0007 0.0007
Onchocerca volvulus Peroxidase homolog 0.0325 0.0466 0.103
Plasmodium vivax calpain, putative 0.1745 0.2696 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0995 0.1519 0.1519
Echinococcus multilocularis EF HAND 1, calcium binding site 0.027 0.0381 0.0381
Schistosoma mansoni Mername-AA248 (C02 family) 0.1745 0.2696 0.2696
Onchocerca volvulus 0.0995 0.1519 0.3356
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0021 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0014 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0015 0.0044
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.027 0.0381 0.0375
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0512 0.076 0.2212
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.2691
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Plasmodium falciparum plasmepsin V 0.0029 0.0002 0.0011
Echinococcus multilocularis programmed cell death protein 0.0284 0.0403 0.0403
Onchocerca volvulus 0.0038 0.0015 0.0034
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0059 0.0048 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0151 0.1507
Schistosoma mansoni hypothetical protein 0.005 0.0034 0.0034
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0336 0.0485 0.0485
Leishmania major calpain family cysteine protease-like protein 0.0512 0.076 0.2202
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0021 0.0014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1745 0.2696 0.2691
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.002 0.002
Trypanosoma brucei I/6 autoantigen 0.027 0.0381 0.1111
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0196 0.0565
Brugia malayi hypothetical protein 0.0046 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0336 0.0485 0.0485
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0017 0.0017
Schistosoma mansoni cpg binding protein 0.0029 0.0002 0.0002
Echinococcus granulosus caspase 2 0.0057 0.0045 0.0045
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0416 0.0409
Plasmodium falciparum peptidase, putative 0.0179 0.0238 0.1565
Loa Loa (eye worm) peptidase C13 family protein 0.0152 0.0196 0.0196
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0032 0.0007 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0336 0.0485 0.0485
Schistosoma mansoni calpain-7 (C02 family) 0.1748 0.2701 0.2701
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0179 0.0238 0.1226
Brugia malayi Cathepsin L-like precursor 0.0995 0.1519 0.1519
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0138 0.0173 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0017 0.0017
Echinococcus multilocularis microtubule associated protein 2 0.1403 0.2159 0.2159
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0014 0.0041
Trichomonas vaginalis calmodulin, putative 0.027 0.0381 0.1106
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0017 0.0017
Toxoplasma gondii exonuclease III APE 0.0037 0.0014 0.0041
Echinococcus multilocularis programmed cell death protein 0.0284 0.0403 0.0403
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0336 0.0485 0.0485
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0196 0.0565
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0005 0.0005
Loa Loa (eye worm) fibroinase 0.0995 0.1519 0.1519
Brugia malayi beta-lactamase 0.0038 0.0015 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0031 0.0031
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0336 0.0485 0.1797
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0015
Leishmania major kinesin, putative 0.1233 0.1892 0.5513
Brugia malayi hypothetical protein 0.0043 0.0024 0.0024
Onchocerca volvulus 0.0059 0.0048 0.0106
Trypanosoma cruzi I/6 autoantigen, putative 0.027 0.0381 0.0375
Schistosoma mansoni reticulocalbin 0.0274 0.0387 0.0387
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.0416 0.1196
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0046 0.0028 0.0028
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0179 0.0238 0.0238
Echinococcus multilocularis hypothetical protein 0.1745 0.2696 0.2696
Toxoplasma gondii hypothetical protein 0.0512 0.076 0.2216
Schistosoma mansoni hypothetical protein 0.0298 0.0425 0.0425
Giardia lamblia Cathepsin B precursor 0.0336 0.0485 0.1398
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0017 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0995 0.1519 0.1519
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0336 0.0485 0.1797
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0015 0.0015
Brugia malayi EF hand family protein 0.027 0.0381 0.0381
Loa Loa (eye worm) cysteine protease 0.0995 0.1519 0.1519
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0021 0.0014
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0125 0.0152 0.0145
Loa Loa (eye worm) animal heme peroxidase 0.0325 0.0466 0.0466
Brugia malayi calcium-binding protein 0.027 0.0381 0.0381
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0336 0.0485 0.319
Loa Loa (eye worm) hypothetical protein 0.1596 0.2463 0.2463
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.027 0.0381 0.1106
Schistosoma mansoni rab 0.027 0.0381 0.0381
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0032 0.0007 0.0006
Onchocerca volvulus 0.0059 0.0048 0.0106
Brugia malayi transcriptional regulator, Sir2 family protein 0.0032 0.0007 0.0007
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0155 0.02 0.02
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0336 0.0485 0.0485
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.221 0.3428 1
Entamoeba histolytica protein kinase, putative 0.1233 0.1892 1
Brugia malayi prolyl oligopeptidase family protein 0.0223 0.0306 0.0306
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0015 0.004
Echinococcus granulosus calpain 0.1745 0.2696 0.2696
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0017 0.0017
Echinococcus multilocularis EF hand domain containing family member A2 0.027 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0995 0.1519 0.1519
Schistosoma mansoni ap endonuclease 0.0037 0.0014 0.0014
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0032 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0336 0.0485 0.0485
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.6395 1 1
Leishmania major cathepsin L-like protease 0.0995 0.1519 0.4422
Schistosoma mansoni hypothetical protein 0.0397 0.058 0.058
Plasmodium falciparum serine repeat antigen 2 0.0336 0.0485 0.319
Toxoplasma gondii calmodulin CAM1 0.0274 0.0387 0.1129
Schistosoma mansoni hypothetical protein 0.0059 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0082 0.0086 0.0086
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0014 0.004
Loa Loa (eye worm) hypothetical protein 0.0059 0.0048 0.0048
Toxoplasma gondii cathepsin CPL 0.0995 0.1519 0.4432
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0151 0.1507
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Entamoeba histolytica calcium-binding protein, putative 0.027 0.0381 0.1985
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0046 0.0028 0.0028
Giardia lamblia Cathepsin L precursor 0.0336 0.0485 0.1398
Loa Loa (eye worm) programmed cell death protein 6 0.0274 0.0387 0.0387
Plasmodium vivax unspecified product 0.0336 0.0485 0.1797
Giardia lamblia Cysteine protease 0.0336 0.0485 0.1398
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0046 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0243 0.0337 0.0337
Trichomonas vaginalis calcium binding protein, putative 0.027 0.0381 0.1106
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0151 0.0151
Onchocerca volvulus 0.0995 0.1519 0.3356
Brugia malayi Papain family cysteine protease containing protein 0.0604 0.0904 0.0904
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0138 0.0173 0.0499
Echinococcus granulosus expressed protein 0.0759 0.1148 0.1148
Trichomonas vaginalis calmodulin, putative 0.027 0.0381 0.1106
Brugia malayi MH2 domain containing protein 0.0116 0.0138 0.0138
Mycobacterium tuberculosis Conserved protein 0.0038 0.0015 0.004
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Schistosoma mansoni integrin alpha 0.0149 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0005
Plasmodium vivax plasmepsin V, putative 0.0029 0.0002 0.0006
Trypanosoma cruzi calmodulin, putative 0.027 0.0381 0.0375
Brugia malayi transcriptional regulator, Sir2 family protein 0.0032 0.0007 0.0007
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0029 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0336 0.0485 0.1409
Leishmania major silent information regulator 2, putative 0.0125 0.0152 0.0425
Loa Loa (eye worm) animal heme peroxidase 0.0325 0.0466 0.0466
Toxoplasma gondii cathepsin CPC1 0.0336 0.0485 0.1414
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0041 0.002 0.002
Plasmodium vivax NAD-dependent deacetylase, putative 0.0032 0.0007 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0995 0.1519 0.4429
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0223 0.0306 0.0892
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1745 0.2696 0.2691
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.221 0.3428 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0432 0.0635 0.0629
Echinococcus granulosus tumor protein p63 0.0343 0.0496 0.0495
Echinococcus granulosus calpain A 0.4929 0.7698 0.7698
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Brugia malayi Cathepsin L-like precursor 0.0728 0.11 0.11
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0336 0.0485 0.319
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0005
Brugia malayi hypothetical protein 0.0039 0.0017 0.0017
Loa Loa (eye worm) transcriptional regulator 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.0274 0.0387 0.1112
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.221 0.3428 0.3423
Loa Loa (eye worm) hypothetical protein 0.0092 0.01 0.01
Echinococcus multilocularis cathepsin b 0.6395 1 1
Entamoeba histolytica cysteine protease, putative 0.0336 0.0485 0.2535
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.0057 0.0045 0.0045
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0007 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Schistosoma mansoni calmodulin 0.027 0.0381 0.0381
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0032 0.0007 0.0006
Onchocerca volvulus 0.0059 0.0048 0.0106
Loa Loa (eye worm) ctsf protein 0.0995 0.1519 0.1519
Trypanosoma cruzi cruzipain precursor, putative 0.0267 0.0376 0.0369
Plasmodium falciparum cysteine proteinase falcipain 1 0.0604 0.0904 0.5951
Loa Loa (eye worm) transcriptional regulator 0.0032 0.0007 0.0007
Brugia malayi Cathepsin L-like precursor 0.0995 0.1519 0.1519
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0053 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Plasmodium vivax unspecified product 0.0267 0.0376 0.1393
Entamoeba histolytica cysteine protease, putative 0.0336 0.0485 0.2535
Echinococcus granulosus EF hand domain containing family member A2 0.027 0.0381 0.0381
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.002 0.002
Trichomonas vaginalis calmodulin, putative 0.0284 0.0403 0.117
Trichomonas vaginalis calmodulin, putative 0.027 0.0381 0.1106
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0007 0.0007
Loa Loa (eye worm) EF hand family protein 0.027 0.0381 0.0381
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0824 0.125 0.1244
Trichomonas vaginalis set domain proteins, putative 0.0723 0.1092 0.3183
Onchocerca volvulus 0.0995 0.1519 0.3356
Echinococcus multilocularis EF hand domain containing family member A2 0.0274 0.0387 0.0387
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0046 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.0904 0.2637
Plasmodium falciparum plasmepsin IX 0.011 0.0129 0.0849
Leishmania major calmodulin, putative 0.027 0.0381 0.1094
Brugia malayi Papain family cysteine protease containing protein 0.0336 0.0485 0.0485
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0071 0.0067 0.0067
Brugia malayi RNA, U transporter 1 0.0079 0.0081 0.0081
Schistosoma mansoni neuronal calcium sensor 0.027 0.0381 0.0381
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.0904 0.4759
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0017 0.0017
Plasmodium falciparum proteasome subunit beta type-5 0.0155 0.02 0.1317
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0174 0.0489
Loa Loa (eye worm) hypothetical protein 0.0728 0.11 0.11
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.01 0.01
Entamoeba histolytica cysteine proteinase, putative 0.0995 0.1519 0.8021
Onchocerca volvulus 0.0995 0.1519 0.3356
Loa Loa (eye worm) hypothetical protein 0.0059 0.0048 0.0048
Leishmania major proteasome beta 2 subunit, putative 0.0046 0.0028 0.0064
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0138 0.0173 0.0173
Echinococcus granulosus gamma secretase subunit aph 1 0.0266 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0179 0.0238 0.0238
Schistosoma mansoni neuronal calcium sensor 0.027 0.0381 0.0381
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0512 0.076 0.0754
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0267 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0117 0.014 0.014
Toxoplasma gondii calcium-dependent protein kinase 0.0274 0.0387 0.1129
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0032 0.0007 0.0006
Trypanosoma cruzi kinesin, putative 0.1233 0.1892 0.1887
Brugia malayi Animal haem peroxidase family protein 0.0325 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0059 0.0048 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0031 0.0031
Giardia lamblia Cathepsin B precursor 0.221 0.3428 1
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0367 0.0532 0.0532
Trypanosoma cruzi Aph-1 protein, putative 0.0104 0.0119 0.0113
Trypanosoma brucei calmodulin, putative 0.027 0.0381 0.1111
Giardia lamblia Cathepsin B precursor 0.0336 0.0485 0.1398
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0017 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0015 0.004
Plasmodium vivax SET domain protein, putative 0.0092 0.01 0.0371
Onchocerca volvulus Prolyl endopeptidase homolog 0.1596 0.2463 0.544
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0071 0.0067 0.0178
Trichomonas vaginalis esterase, putative 0.0038 0.0015 0.0039
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.2691
Trypanosoma brucei cysteine peptidase C (CPC) 0.221 0.3428 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0071 0.0067 0.0061
Giardia lamblia Encystation-specific protease 0.0336 0.0485 0.1398
Echinococcus multilocularis cathepsin b 0.6395 1 1
Plasmodium falciparum plasmepsin II 0.0029 0.0002 0.0011
Trypanosoma brucei prolyl oligopeptidase, putative 0.0643 0.0966 0.2817
Loa Loa (eye worm) integrin alpha pat-2 0.023 0.0318 0.0318
Echinococcus granulosus peroxidasin 0.0325 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Leishmania major cathepsin L-like protease 0.0995 0.1519 0.4422
Echinococcus multilocularis integrin alpha ps 0.0032 0.0007 0.0007
Onchocerca volvulus Peroxidasin homolog 0.0325 0.0466 0.103
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0015
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.027 0.0381 0.0381
Entamoeba histolytica cysteine proteinase, putative 0.0995 0.1519 0.8021
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0336 0.0485 0.1398
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0155 0.02 0.0584
Echinococcus granulosus Dipeptidyl peptidase 9 0.0223 0.0306 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Schistosoma mansoni centrin 0.027 0.0381 0.0381
Onchocerca volvulus 0.027 0.0381 0.0841
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0035
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1745 0.2696 0.2691
Giardia lamblia Cathepsin B precursor 0.221 0.3428 1
Schistosoma mansoni cathepsin F (C01 family) 0.0995 0.1519 0.1519
Trypanosoma cruzi caltractin, putative 0.027 0.0381 0.0375
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0223 0.0306 0.0875
Onchocerca volvulus 0.027 0.0381 0.0841
Echinococcus multilocularis caspase 2 0.0057 0.0045 0.0045
Loa Loa (eye worm) proteasome subunit beta type 2 0.0046 0.0028 0.0028
Leishmania major programmed cell death 6 protein-like protein 0.027 0.0381 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Mycobacterium tuberculosis Conserved protein 0.0038 0.0015 0.004
Schistosoma mansoni reticulocalbin 0.027 0.0381 0.0381
Schistosoma mansoni ef hand domain family member A2 0.027 0.0381 0.0381
Trichomonas vaginalis calcium binding protein, putative 0.027 0.0381 0.1106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0031 0.0031
Entamoeba histolytica prolyl oligopeptidase family protein 0.0179 0.0238 0.1226
Giardia lamblia Cysteine protease 0.0336 0.0485 0.1398
Echinococcus multilocularis calmodulin 0.027 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0059 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Echinococcus multilocularis calpain A 0.4929 0.7698 0.7698
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0071 0.0067 0.0067
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0643 0.0966 0.2803
Plasmodium vivax proteasome subunit beta type-5, putative 0.0155 0.02 0.0742
Giardia lamblia Cathepsin L precursor 0.0336 0.0485 0.1398
Brugia malayi hypothetical protein 0.0031 0.0005 0.0005
Echinococcus multilocularis integrin alpha 3 0.0115 0.0136 0.0136
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0336 0.0485 0.1797
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0014 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0048 0.0048
Schistosoma mansoni mitochondrial solute carrier 0.027 0.0381 0.0381
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0044 0.0129
Loa Loa (eye worm) hypothetical protein 0.0106 0.0122 0.0122
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0017 0.0017
Giardia lamblia Cathepsin L-like protease 0.0336 0.0485 0.1398
Trypanosoma cruzi Aph-1 protein, putative 0.0104 0.0119 0.0113
Entamoeba histolytica cysteine protease, putative 0.0995 0.1519 0.8021
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Leishmania major cytochrome p450-like protein 0.0032 0.0007 0.0001
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0071 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0029 0.0002 0.0005
Brugia malayi Cathepsin L-like precursor 0.0995 0.1519 0.1519
Trypanosoma brucei centrin, putative 0.027 0.0381 0.1111
Plasmodium vivax proteasome subunit beta type-1, putative 0.0071 0.0067 0.025
Echinococcus granulosus EF hand domain containing family member A2 0.0274 0.0387 0.0387
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0017 0.0017
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1745 0.2696 0.2691
Brugia malayi Proteasome A-type and B-type family protein 0.0155 0.02 0.02
Brugia malayi Cell death protein 3 precursor 0.0057 0.0045 0.0045
Giardia lamblia Proteasome subunit beta type 1 0.0071 0.0067 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Toxoplasma gondii prolyl endopeptidase 0.1596 0.2463 0.7184
Entamoeba histolytica hypothetical protein, conserved 0.0274 0.0387 0.2018
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0179 0.0238 0.1226
Loa Loa (eye worm) hypothetical protein 0.0059 0.0048 0.0048
Brugia malayi calpain 5 0.0512 0.076 0.076
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0179 0.0238 0.0689
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0512 0.076 0.0754
Brugia malayi cathepsin L-like cysteine proteinase 0.0336 0.0485 0.0485
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0512 0.076 0.2212
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0336 0.0485 0.2535
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0046 0.0028 0.0082
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0604 0.0904 0.0898
Toxoplasma gondii EF hand domain-containing protein 0.027 0.0381 0.1111
Echinococcus multilocularis enteropeptidase 0.0059 0.0048 0.0048
Echinococcus multilocularis expressed protein 0.0759 0.1148 0.1148
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.01 0.01
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0125 0.0152 0.0771
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0015 0.0039
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Loa Loa (eye worm) aspartyl protease 6 0.0029 0.0002 0.0002
Schistosoma mansoni neuronal calcium sensor 0.027 0.0381 0.0381
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.6395 1 1
Echinococcus granulosus EF HAND 1 calcium binding site 0.027 0.0381 0.0381
Toxoplasma gondii histone deacetylase SIR2 0.0032 0.0007 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0014 0.0008
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0336 0.0485 0.1797
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Schistosoma mansoni hypothetical protein 0.0117 0.014 0.014
Leishmania major hypothetical protein, conserved 0.0038 0.0015 0.0025
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0032 0.0007 0.0042
Schistosoma mansoni calpain (C02 family) 0.1745 0.2696 0.2696
Toxoplasma gondii proteasome subunit beta type, putative 0.0155 0.02 0.0584
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0512 0.076 0.2216
Mycobacterium ulcerans beta-lactamase 0.0038 0.0015 0.0091
Schistosoma mansoni calmodulin related calcium binding protein 0.027 0.0381 0.0381
Brugia malayi Pre-SET motif family protein 0.0092 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0728 0.11 0.3205
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0267 0.0376 0.0376
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0266 0.0374 0.0374
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0014 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Entamoeba histolytica calpain family cysteine protease, putative 0.0512 0.076 0.3994
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0034 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0031 0.0031
Toxoplasma gondii aspartyl protease 0.0029 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Schistosoma mansoni chromatin regulatory protein sir2 0.0125 0.0152 0.0152
Plasmodium vivax vivapain-2 0.0995 0.1519 0.5635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0728 0.11 0.3205
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0512 0.076 0.2216
Echinococcus granulosus acylamino acid releasing enzyme 0.0179 0.0238 0.0238
Plasmodium vivax centrin-1, putative 0.027 0.0381 0.1412
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1745 0.2696 0.2691
Plasmodium falciparum plasmepsin VI 0.0029 0.0002 0.0011
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0096 0.0107 0.0107
Echinococcus granulosus snurportin 1 0.0298 0.0425 0.0425
Brugia malayi Cathepsin L-like precursor 0.0995 0.1519 0.1519
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0336 0.0485 0.1409
Plasmodium vivax vivapain-3 0.0604 0.0904 0.3353
Trypanosoma cruzi prolyl endopeptidase 0.1596 0.2463 0.2458
Schistosoma mansoni integrin alpha-ps 0.0067 0.0061 0.0061
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0155 0.02 0.1027
Brugia malayi Cathepsin L-like precursor 0.0728 0.11 0.11
Entamoeba histolytica calpain large subunit domain III containing protein 0.1233 0.1892 1
Trichomonas vaginalis conserved hypothetical protein 0.0336 0.0485 0.1409
Onchocerca volvulus 0.0038 0.0015 0.0034
Loa Loa (eye worm) calpain 0.1745 0.2696 0.2696
Toxoplasma gondii centrin 0.027 0.0381 0.1111
Trypanosoma cruzi conserved protein 0.0512 0.076 0.0754
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0017 0.0017
Leishmania major cathepsin L-like protease 0.1091 0.1669 0.4861
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0995 0.1519 0.1519
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.0045 0.01
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0336 0.0485 0.1797
Echinococcus granulosus glycoprotein Antigen 5 0.0059 0.0048 0.0048
Schistosoma mansoni importin beta-1 0.0028 0.0000089181 0.0000089181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Leishmania major centrin, putative 0.027 0.0381 0.1094
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0179 0.0238 0.0689
Brugia malayi aspartic protease BmAsp-1, identical 0.0029 0.0002 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0015 0.0015
Brugia malayi proteasome subunit beta type 1 0.0071 0.0067 0.0067
Brugia malayi Integrin alpha pat-2 precursor 0.0149 0.0191 0.0191
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0223 0.0306 0.0892
Plasmodium falciparum plasmepsin X 0.011 0.0129 0.0849
Brugia malayi cathepsin Z-like cysteine proteinase 0.0336 0.0485 0.0485
Echinococcus granulosus calcium uptake protein 1 0.0274 0.0387 0.0387
Giardia lamblia Hypothetical protein 0.0336 0.0485 0.1398
Echinococcus multilocularis prolyl endopeptidase 0.1596 0.2463 0.2462
Plasmodium vivax vivapain-1 0.0604 0.0904 0.3353
Trypanosoma brucei Calpain-like protein CALP1.3 0.0512 0.076 0.2216
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0014 0.5
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Plasmodium falciparum serine repeat antigen 5 0.0336 0.0485 0.319
Echinococcus granulosus dnaJ subfamily B 0.0397 0.058 0.058
Trichomonas vaginalis calcium binding proteins, putative 0.027 0.0381 0.1106
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Onchocerca volvulus 0.0029 0.0002 0.0004
Loa Loa (eye worm) proteasome subunit beta type 1 0.0071 0.0067 0.0067
Onchocerca volvulus Peroxidase homolog 0.0325 0.0466 0.103
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0198 0.0882
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0017 0.0017
Echinococcus multilocularis calpain family protein 1, d 0.3422 0.5331 0.533
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0336 0.0485 0.319
Loa Loa (eye worm) transcriptional regulator 0.0125 0.0152 0.0152
Schistosoma mansoni chromatin regulatory protein sir2 0.0138 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.027 0.0381 0.0381
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.6395 1 1
Giardia lamblia Cathepsin B precursor 0.0336 0.0485 0.1398
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0125 0.0152 0.0771
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Trypanosoma brucei calpain-like protein, putative 0.1745 0.2696 0.7866
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0643 0.0966 0.441
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0138 0.0138
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0512 0.076 0.0754
Mycobacterium ulcerans hypothetical protein 0.0154 0.0198 0.1999
Brugia malayi Eukaryotic aspartyl protease family protein 0.0029 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.2691
Loa Loa (eye worm) hypothetical protein 0.4143 0.6463 0.6463
Toxoplasma gondii troponin c, isotype gamma, putative 0.027 0.0381 0.1111
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Brugia malayi beta-lactamase family protein 0.0038 0.0015 0.0015
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0604 0.0904 0.0904
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0017 0.0017
Onchocerca volvulus Chorion peroxidase homolog 0.0325 0.0466 0.103
Echinococcus granulosus calpain A 0.1745 0.2696 0.2696
Onchocerca volvulus 0.0154 0.0197 0.0436
Loa Loa (eye worm) RNA binding protein 0.0061 0.0053 0.0053
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Schistosoma mansoni integrin alpha-ps 0.0035 0.0011 0.0011
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.7862
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0179 0.0238 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Entamoeba histolytica hypothetical protein 0.0039 0.0017 0.0058
Schistosoma mansoni chromatin regulatory protein sir2 0.0032 0.0007 0.0007
Echinococcus granulosus cathepsin b 0.6395 1 1
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0017 0.0017
Brugia malayi cathepsin L precursor 0.0336 0.0485 0.0485
Loa Loa (eye worm) calpain 5 0.1233 0.1892 0.1892
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0125 0.0152 0.0438
Brugia malayi Animal haem peroxidase family protein 0.0325 0.0466 0.0466
Entamoeba histolytica cysteine protease, putative 0.0336 0.0485 0.2535
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.01 0.01
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Loa Loa (eye worm) beta-lactamase 0.0038 0.0015 0.0015
Trichomonas vaginalis calmodulin-2, putative 0.027 0.0381 0.1106
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0029 0.0002 0.0002
Plasmodium vivax unspecified product 0.0604 0.0904 0.3353
Echinococcus multilocularis chromatin regulatory protein sir2 0.0125 0.0152 0.0152
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0138 0.0173 0.0486
Plasmodium falciparum centrin-1 0.027 0.0381 0.2506
Trypanosoma brucei Component of motile flagella 41 0.027 0.0381 0.1111
Echinococcus granulosus neuronal calcium sensor 0.027 0.0381 0.0381
Giardia lamblia Alanyl dipeptidyl peptidase 0.0179 0.0238 0.0676
Trypanosoma cruzi calmodulin, putative 0.027 0.0381 0.0375
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.0904 0.4759
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0274 0.0387 0.0387
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0336 0.0485 0.0485
Onchocerca volvulus 0.0325 0.0466 0.103
Brugia malayi Trypsin family protein 0.0059 0.0048 0.0048
Echinococcus granulosus caspase 0.0096 0.0107 0.0107
Onchocerca volvulus 0.0995 0.1519 0.3356
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0015 0.0009
Entamoeba histolytica cysteine protease, putative 0.0336 0.0485 0.2535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0336 0.0485 0.1409
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0125 0.0152 0.0443
Echinococcus multilocularis caspase 0.0096 0.0107 0.0107
Plasmodium vivax hypothetical protein, conserved 0.0179 0.0238 0.0882
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0196 0.0565
Echinococcus multilocularis snurportin 1 0.0298 0.0425 0.0425
Onchocerca volvulus 0.0059 0.0048 0.0106
Brugia malayi hypothetical protein 0.0154 0.0197 0.0197
Giardia lamblia Cathepsin L precursor 0.0336 0.0485 0.1398
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0367 0.0532 0.0532
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.0904 0.2637
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0031 0.0031
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0017 0.0017
Brugia malayi Cytochrome P450 family protein 0.0032 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0995 0.1519 0.4422
Echinococcus granulosus programmed cell death protein 0.0284 0.0403 0.0403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Trichomonas vaginalis calcium binding protein, putative 0.0284 0.0403 0.117
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.4925 0.7691 0.7691
Giardia lamblia Cysteine protease 0.0336 0.0485 0.1398
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0031 0.0031
Trichomonas vaginalis calpain, putative 0.0512 0.076 0.2212
Brugia malayi cathepsin F-like cysteine proteinase 0.0267 0.0376 0.0376
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1596 0.2463 0.2463
Schistosoma mansoni integrin beta subunit 0.018 0.0239 0.0239
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.027 0.0381 0.1111
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0017 0.0017
Brugia malayi Cytochrome P450 family protein 0.0053 0.004 0.004
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0155 0.02 0.0194
Trypanosoma cruzi calmodulin, putative 0.027 0.0381 0.0375
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0017 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.221 0.3428 0.3428
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.002
Trypanosoma brucei Aph-1 protein, putative 0.0104 0.0119 0.0347
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0643 0.0966 0.096
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.0045 0.0045
Trypanosoma cruzi centrin, putative 0.0284 0.0403 0.0396
Brugia malayi hypothetical protein 0.0029 0.0002 0.0002
Brugia malayi Papain family cysteine protease containing protein 0.0604 0.0904 0.0904
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0196 0.0565
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0336 0.0485 0.1797
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.027 0.0381 0.0375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Brugia malayi transcriptional regulator, Sir2 family protein 0.0125 0.0152 0.0152
Echinococcus granulosus cathepsin l cysteine peptidase 0.0995 0.1519 0.1519
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.0425 0.0425
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Echinococcus granulosus cpg binding protein 0.0029 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0336 0.0485 0.0485
Plasmodium falciparum cysteine proteinase falcipain 3 0.0995 0.1519 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0151 0.1507
Leishmania major calmodulin, putative 0.027 0.0381 0.1094
Schistosoma mansoni cathepsin B (C01 family) 0.0336 0.0485 0.0485
Brugia malayi hypothetical protein 0.0325 0.0466 0.0466
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0021 0.0061
Trypanosoma brucei centrin-3 0.0284 0.0403 0.1174
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0512 0.076 0.0754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Echinococcus multilocularis GPI anchor transamidase 0.0035 0.0012 0.0012
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0336 0.0485 0.1398
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0015 0.0039
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0029 0.0002 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.0904 0.4759
Echinococcus multilocularis cysteine protease 0.0995 0.1519 0.1519
Schistosoma mansoni cathepsin S (C01 family) 0.0336 0.0485 0.0485
Trichomonas vaginalis calpain, putative 0.0512 0.076 0.2212
Trypanosoma cruzi major cysteine proteinase, putative 0.0336 0.0485 0.0478
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0035 0.0012 0.0012
Onchocerca volvulus 0.005 0.0035 0.0078
Entamoeba histolytica cysteine proteinase 1, putative 0.0604 0.0904 0.4759
Brugia malayi prolyl oligopeptidase family protein 0.0179 0.0238 0.0238
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Trypanosoma brucei Calpain-like protein 2 0.0512 0.076 0.2216
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0017 0.0017
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0336 0.0485 0.1797
Plasmodium falciparum serine repeat antigen 7 0.0336 0.0485 0.319
Brugia malayi hypothetical protein 0.0059 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Echinococcus granulosus calpain 5 0.1745 0.2696 0.2696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Mycobacterium tuberculosis Probable peptidase 0.0643 0.0966 0.441
Trichomonas vaginalis centrin, putative 0.027 0.0381 0.1106
Giardia lamblia Proteasome subunit beta type 2 0.0046 0.0028 0.0064
Loa Loa (eye worm) trypsin family protein 0.0059 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.027 0.0381 0.1106
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0017 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.0336 0.0485 0.0485
Schistosoma mansoni centrin-related 0.027 0.0381 0.0381
Echinococcus granulosus calbindin 32 0.0274 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Loa Loa (eye worm) prolyl oligopeptidase 0.0179 0.0238 0.0238
Leishmania major cathepsin L-like protease 0.0995 0.1519 0.4422
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Loa Loa (eye worm) calpain family protein 1 0.4655 0.7267 0.7267
Loa Loa (eye worm) hypothetical protein 0.0154 0.0197 0.0197
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0014 0.008
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1596 0.2463 0.2463
Trypanosoma brucei hypothetical protein, conserved 0.027 0.0381 0.1111
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0238 0.0231
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0015
Brugia malayi Peptidase C13 family protein 0.0152 0.0196 0.0196
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0336 0.0485 0.1409
Schistosoma mansoni chromatin regulatory protein sir2 0.0032 0.0007 0.0007
Echinococcus granulosus integrin beta 2 0.0227 0.0312 0.0312
Giardia lamblia Hypothetical protein 0.0336 0.0485 0.1398
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0032 0.0007 0.0014
Schistosoma mansoni hemoglobinase (C13 family) 0.0152 0.0196 0.0196
Giardia lamblia Cathepsin L precursor 0.0336 0.0485 0.1398
Echinococcus granulosus microtubule associated protein 2 0.1403 0.2159 0.2159
Loa Loa (eye worm) hypothetical protein 0.0267 0.0376 0.0376
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0035 0.0012 0.0034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0125 0.0152 0.0438
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.027 0.0381 0.1412
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0032 0.0007 0.0014
Echinococcus multilocularis calcium uptake protein 1 0.0274 0.0387 0.0387
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2216
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.0337 0.0337
Brugia malayi NAD-dependent deacetylase SIRT1 0.0138 0.0173 0.0173
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0071 0.0067 0.0196
Trypanosoma brucei hypothetical protein 0.0512 0.076 0.2216
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0015 0.0039
Plasmodium falciparum serine repeat antigen 9 0.0336 0.0485 0.319
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0336 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0024
Brugia malayi Calmodulin-like protein 0.027 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0113 0.0134 0.0134
Brugia malayi calpain family protein 1 0.4655 0.7267 0.7267
Brugia malayi Animal haem peroxidase family protein 0.0325 0.0466 0.0466
Echinococcus granulosus integrin alpha ps 0.0032 0.0007 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.0904 0.4759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0367 0.0532 0.0532
Mycobacterium ulcerans lipase LipD 0.0038 0.0015 0.0091
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Plasmodium vivax plasmepsin IV, putative 0.0029 0.0002 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.01 0.01
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0014 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0336 0.0485 0.1409
Brugia malayi gamma-secretase subunit aph-1 0.0266 0.0374 0.0374
Plasmodium falciparum plasmepsin VII 0.0029 0.0002 0.0011
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0334 0.0481 0.0481
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1417 0.2181 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0071 0.0067 0.0061
Plasmodium falciparum calpain 0.0512 0.076 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0059 0.0048 0.0048
Schistosoma mansoni calpain-2 (C02 family) 0.0512 0.076 0.076
Plasmodium vivax proteasome subunit beta type-2, putative 0.0046 0.0028 0.0105
Leishmania major hypothetical protein, unknown function 0.0512 0.076 0.2202
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0336 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0015 0.0091
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0995 0.1519 0.4429
Trichomonas vaginalis hypothetical protein 0.0512 0.076 0.2212
Brugia malayi Papain family cysteine protease containing protein 0.0995 0.1519 0.1519
Mycobacterium ulcerans proteasome PrcB 0.0155 0.02 0.2019
Toxoplasma gondii ABC1 family protein 0.0038 0.0015 0.0044
Toxoplasma gondii cathepsin B 0.221 0.3428 1
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0017 0.0017
Echinococcus granulosus inhibitor of apoptosis protein 0.0041 0.002 0.002
Toxoplasma gondii hypothetical protein 0.0179 0.0238 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0045
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0059 0.0048 0.0048
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0223 0.0306 0.0299
Onchocerca volvulus 0.2911 0.4527 1
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Loa Loa (eye worm) hypothetical protein 0.027 0.0381 0.0381
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0196 0.0565
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Brugia malayi prolyl oligopeptidase family protein 0.0179 0.0238 0.0238
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0015 0.004
Leishmania major i/6 autoantigen-like protein 0.027 0.0381 0.1094
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.4925 0.7691 0.7691
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0017 0.0017
Brugia malayi prolyl oligopeptidase family protein 0.0334 0.0481 0.0481
Schistosoma mansoni cathepsin F (C01 family) 0.0728 0.11 0.11
Echinococcus multilocularis proteasome (prosome, macropain) 0.0155 0.02 0.02
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0039 0.0017 0.0058
Loa Loa (eye worm) prolyl oligopeptidase 0.0334 0.0481 0.0481
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1596 0.2463 0.7179
Loa Loa (eye worm) hypothetical protein 0.0728 0.11 0.11
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0336 0.0485 0.0485
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.027 0.0381 0.0375
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Leishmania major cysteine peptidase A (CPA) 0.0995 0.1519 0.4422
Schistosoma mansoni neuronal calcium sensor 0.027 0.0381 0.0381
Onchocerca volvulus Cathepsin L homolog 0.0995 0.1519 0.3356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0336 0.0485 0.1409
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0015 0.0039
Trypanosoma cruzi cruzipain precursor, putative 0.1091 0.1669 0.1664
Echinococcus multilocularis gamma secretase subunit aph 1 0.0266 0.0374 0.0374
Toxoplasma gondii hypothetical protein 0.0047 0.003 0.0088
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Schistosoma mansoni calpain C (C02 family) 0.1745 0.2696 0.2696
Trypanosoma brucei calpain, putative 0.0512 0.076 0.2216
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0046 0.0028 0.0186
Schistosoma mansoni inhibitor of apoptosis protein 0.0041 0.002 0.002
Trypanosoma brucei protein I/6 0.027 0.0381 0.1111
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Toxoplasma gondii peptidase c13 family protein 0.0035 0.0012 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0014 0.0036
Toxoplasma gondii aspartyl protease ASP1 0.0029 0.0002 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.058 0.058
Trypanosoma cruzi oligopeptidase b 0.0643 0.0966 0.096
Echinococcus multilocularis calpain 5 0.1745 0.2696 0.2696
Trypanosoma cruzi cysteine peptidase, putative 0.1091 0.1669 0.1664
Loa Loa (eye worm) hypothetical protein 0.0059 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0138 0.0173 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0512 0.076 0.0754
Trypanosoma cruzi cysteine peptidase, putative 0.1091 0.1669 0.1664
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0151 0.0422
Leishmania major hypothetical protein, conserved 0.027 0.0381 0.1094
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.7862
Trichomonas vaginalis calcium binding protein, putative 0.027 0.0381 0.1106
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0096 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0179 0.0238 0.0238
Giardia lamblia Alanyl dipeptidyl peptidase 0.0179 0.0238 0.0676
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Leishmania major cathepsin L-like protease 0.1091 0.1669 0.4861
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0017 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0174 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0336 0.0485 0.1409
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Onchocerca volvulus Legumain homolog 0.0152 0.0196 0.0432
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0336 0.0485 0.1409
Plasmodium vivax serine-repeat antigen (SERA) 0.0336 0.0485 0.1797
Brugia malayi Pre-SET motif family protein 0.0636 0.0954 0.0954
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0336 0.0485 0.1797
Echinococcus multilocularis acylamino acid releasing enzyme 0.0179 0.0238 0.0238
Schistosoma mansoni peroxidasin 0.0325 0.0466 0.0466
Echinococcus multilocularis cathepsin L 0.0336 0.0485 0.0485
Plasmodium falciparum serine repeat antigen 1 0.0336 0.0485 0.319
Brugia malayi proteasome subunit beta type 2 0.0046 0.0028 0.0028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Trypanosoma brucei centrin, putative 0.027 0.0381 0.1111
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0032 0.0007 0.0014
Brugia malayi calpain 5 0.1233 0.1892 0.1892
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0014 0.0014
Onchocerca volvulus Dual oxidase homolog 0.0325 0.0466 0.103
Echinococcus multilocularis calpain 7 (C02 family) 0.1745 0.2696 0.2696
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0035 0.0035
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0041 0.002 0.002
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0032 0.0007 0.0006
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0035 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0029 0.0029
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0336 0.0485 0.1398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Giardia lamblia Hypothetical protein 0.0125 0.0152 0.0425
Brugia malayi Animal haem peroxidase family protein 0.0325 0.0466 0.0466
Echinococcus granulosus neurocalcin 0.027 0.0381 0.0381
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0017 0.0017
Giardia lamblia Cysteine protease 0.0336 0.0485 0.1398
Toxoplasma gondii EFHC1, putative 0.027 0.0381 0.1111
Echinococcus multilocularis integrin alpha ps 0.0067 0.0061 0.0061
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0512 0.076 0.0754
Brugia malayi Trypsin family protein 0.0059 0.0048 0.0048
Onchocerca volvulus 0.0038 0.0015 0.0034
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0995 0.1519 0.1519
Echinococcus granulosus transmembrane protease serine 3 0.0059 0.0048 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0015 0.004
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0015
Echinococcus multilocularis cpg binding protein 0.0029 0.0002 0.0002
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0223 0.0306 0.0306
Echinococcus multilocularis integrin beta 2 0.0227 0.0312 0.0312
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0015 0.0091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Loa Loa (eye worm) hypothetical protein 0.4655 0.7267 0.7267
Schistosoma mansoni hypothetical protein 0.027 0.0381 0.0381
Echinococcus granulosus cathepsin L 0.0604 0.0904 0.0904
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0336 0.0485 0.1409
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Onchocerca volvulus 0.0325 0.0466 0.103
Trypanosoma brucei Calpain-like protein 1.2 0.0512 0.076 0.2216
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0336 0.0485 0.2535
Echinococcus granulosus cathepsin L 0.0336 0.0485 0.0485
Trichomonas vaginalis calcineurin B subunit, putative 0.0274 0.0387 0.1125
Onchocerca volvulus 0.0029 0.0002 0.0004
Brugia malayi Integrin beta pat-3 precursor 0.0306 0.0437 0.0437
Echinococcus granulosus cathepsin b 0.6395 1 1
Brugia malayi GPI-anchor transamidase 0.0035 0.0012 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Brugia malayi beta-lactamase family protein 0.0038 0.0015 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0604 0.0904 0.2634
Plasmodium falciparum serine repeat antigen 6 0.0336 0.0485 0.319
Loa Loa (eye worm) hypothetical protein 0.0512 0.076 0.076
Onchocerca volvulus 0.0728 0.11 0.2429
Loa Loa (eye worm) hypothetical protein 0.0336 0.0485 0.0485
Trypanosoma brucei calmodulin, putative 0.0274 0.0387 0.1129
Trypanosoma brucei cysteine peptidase, putative 0.0512 0.076 0.2216
Brugia malayi Angiotensin-converting enzyme family protein 0.0602 0.0901 0.0901
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0336 0.0485 0.1797
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0017 0.0017
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0643 0.0966 0.096
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.004 0.004
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0155 0.02 0.1946
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0071 0.0067 0.0323
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0017 0.0017
Trichomonas vaginalis calpain, putative 0.0512 0.076 0.2212
Schistosoma mansoni calmodulin 0.027 0.0381 0.0381
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0017 0.0017
Brugia malayi hypothetical protein 0.0243 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0336 0.0485 0.1409
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0604 0.0904 0.0904
Echinococcus multilocularis integrin alpha ps 0.0067 0.0061 0.0061
Plasmodium falciparum serine repeat antigen 8 0.0336 0.0485 0.319
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0012 0.0029
Echinococcus multilocularis cathepsin L 0.0604 0.0904 0.0904
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.6395 1 1
Brugia malayi prolyl oligopeptidase family protein 0.1596 0.2463 0.2463
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0017 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0416 0.0409
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0155 0.02 0.0194
Loa Loa (eye worm) hypothetical protein 0.0267 0.0376 0.0376
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0995 0.1519 0.1519
Echinococcus granulosus cathepsin L cysteine proteinase 0.0995 0.1519 0.1519
Brugia malayi Trypsin family protein 0.0059 0.0048 0.0048
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0012 0.0029
Trypanosoma brucei prolyl endopeptidase 0.1596 0.2463 0.7184
Echinococcus granulosus calumenin 0.0274 0.0387 0.0387
Schistosoma mansoni cathepsin D (A01 family) 0.0124 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0015
Brugia malayi fibroinase precursor 0.0336 0.0485 0.0485
Echinococcus multilocularis tumor protein p63 0.0343 0.0496 0.0495
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0053 0.0053
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0046 0.0028 0.0077
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.027 0.0381 0.0375
Giardia lamblia Cathepsin L-like protease 0.0336 0.0485 0.1398
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0174 0.0507
Brugia malayi RNA binding protein 0.0061 0.0053 0.0053
Mycobacterium ulcerans hypothetical protein 0.0059 0.0048 0.0434
Entamoeba histolytica cysteine protease, putative 0.0336 0.0485 0.2535
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0336 0.0485 0.1409
Plasmodium vivax serine-repeat antigen (SERA) 0.0336 0.0485 0.1797
Plasmodium falciparum plasmepsin IV 0.0029 0.0002 0.0011
Leishmania major cathepsin L-like protease 0.1091 0.1669 0.4861
Leishmania major hypothetical protein, conserved 0.0512 0.076 0.2202
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0179 0.0238 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2216
Schistosoma mansoni gamma-secretase subunit aph-1 0.0266 0.0374 0.0374
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0336 0.0485 0.0485
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0014 0.0014
Mycobacterium ulcerans hypothetical protein 0.0038 0.0015 0.0091
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0041 0.002 0.002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0512 0.076 0.0754
Brugia malayi Cathepsin L-like precursor 0.0995 0.1519 0.1519
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0336 0.0485 0.1398
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0155 0.02 0.0579
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0017 0.0017
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0155 0.02 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0336 0.0485 0.1409
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0138 0.0173 0.0499
Schistosoma mansoni caspase-3 (C14 family) 0.0096 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0012
Onchocerca volvulus 0.0336 0.0485 0.1071
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Leishmania major calcineurin B subunit, putative 0.027 0.0381 0.1094
Leishmania major oligopeptidase b 0.0643 0.0966 0.2803
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Toxoplasma gondii cathepsin CPC2 0.0336 0.0485 0.1414
Echinococcus multilocularis calbindin 32 0.0274 0.0387 0.0387
Trypanosoma cruzi cysteine proteinase, putative 0.0604 0.0904 0.0898
Echinococcus multilocularis calpain 0.1745 0.2696 0.2696
Trypanosoma brucei Calpain-like protein 1.1 0.0512 0.076 0.2216
Echinococcus granulosus cathepsin l1 0.0728 0.11 0.11
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0041 0.002 0.002
Schistosoma mansoni ap endonuclease 0.0037 0.0014 0.0014
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0032 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0015
Brugia malayi Pepsin A precursor 0.0029 0.0002 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0014 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.0333 0.1502
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.6395 1 1
Onchocerca volvulus 0.0041 0.002 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0007 0.0007
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Giardia lamblia Cathepsin B precursor 0.221 0.3428 1
Trypanosoma cruzi cysteine proteinase, putative 0.0604 0.0904 0.0898
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0015 0.0015
Trichomonas vaginalis calmodulin, putative 0.027 0.0381 0.1106
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Onchocerca volvulus 0.0325 0.0466 0.103
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0053 0.0053
Brugia malayi PXA domain containing protein 0.0039 0.0017 0.0017
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0336 0.0485 0.0485
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0046 0.0028 0.0082
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0031 0.0031
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0017 0.0017
Echinococcus granulosus calpain 7 C02 family 0.1745 0.2696 0.2696
Entamoeba histolytica cysteine protease, putative 0.0336 0.0485 0.2535
Plasmodium falciparum GPI-anchor transamidase, putative 0.0035 0.0012 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.01 0.01
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0059 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0336 0.0485 0.0485
Trypanosoma cruzi centrin, putative 0.0284 0.0403 0.0396
Echinococcus multilocularis transmembrane protease serine 3 0.0059 0.0048 0.0048
Entamoeba histolytica calmodulin, putative 0.027 0.0381 0.1985
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.027 0.0381 0.1106
Plasmodium vivax aspartyl proteinase, putative 0.0029 0.0002 0.0006
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0017 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0336 0.0485 0.0485
Onchocerca volvulus 0.0092 0.01 0.0221
Echinococcus multilocularis cathepsin L cysteine protease 0.0995 0.1519 0.1519
Onchocerca volvulus 0.0059 0.0048 0.0106
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0636 0.0954 0.0954
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1745 0.2696 0.7866
Echinococcus granulosus integrin alpha 3 0.0115 0.0136 0.0136
Brugia malayi EF hand family protein 0.0274 0.0387 0.0387
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0336 0.0485 0.1797
Entamoeba histolytica prolyl oligopeptidase family protein 0.0179 0.0238 0.1226
Trypanosoma brucei calpain-like protein, putative 0.1745 0.2696 0.7866
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0046 0.0028 0.0028
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0014 0.0035
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0152 0.0196 0.0196
Brugia malayi Cathepsin L-like cysteine proteinase 0.0728 0.11 0.11
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0512 0.076 0.2212
Giardia lamblia Cathepsin B precursor 0.0336 0.0485 0.1398
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0334 0.0481 0.0481
Plasmodium vivax vivapain-2 0.0995 0.1519 0.5635
Echinococcus granulosus GPI anchor transamidase 0.0035 0.0012 0.0012
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0336 0.0485 0.2535
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Echinococcus granulosus enteropeptidase 0.0059 0.0048 0.0048
Brugia malayi Cathepsin L-like precursor 0.0995 0.1519 0.1519
Onchocerca volvulus 0.0724 0.1093 0.2413
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0059 0.0048 0.0048
Echinococcus granulosus sarcoplasmic calcium binding protein 0.027 0.0381 0.0381
Schistosoma mansoni peroxidasin 0.0325 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0336 0.0485 0.1409
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0512 0.076 0.2212
Leishmania major calpain protease-like protein 0.0512 0.076 0.2202
Giardia lamblia Hypothetical protein 0.0274 0.0387 0.1112
Echinococcus multilocularis inhibitor of apoptosis protein 0.0041 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0336 0.0485 0.1409
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0029 0.0002 0.0002
Loa Loa (eye worm) cathepsin B 0.221 0.3428 0.3428
Trypanosoma brucei antigen, putative 0.1745 0.2696 0.7866
Loa Loa (eye worm) hypothetical protein 0.0325 0.0466 0.0466
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0995 0.1519 1
Schistosoma mansoni survival motor neuron protein 0.005 0.0034 0.0034
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0029 0.0029
Trichomonas vaginalis calmodulin, putative 0.0274 0.0387 0.1125
Entamoeba histolytica prolyl oligopeptidase family protein 0.0179 0.0238 0.1226
Trichomonas vaginalis calcineurin B subunit, putative 0.027 0.0381 0.1106
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0512 0.076 0.2212
Giardia lamblia Cathepsin L precursor 0.0336 0.0485 0.1398
Trypanosoma cruzi cysteine peptidase, putative 0.0267 0.0376 0.0369
Toxoplasma gondii preprocathepsin c precursor, putative 0.0336 0.0485 0.1414
Trypanosoma brucei kinesin, putative 0.1233 0.1892 0.5521
Loa Loa (eye worm) animal heme peroxidase 0.0325 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0336 0.0485 0.1409
Brugia malayi Papain family cysteine protease containing protein 0.0336 0.0485 0.0485
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0015 0.004
Schistosoma mansoni cpg binding protein 0.0029 0.0002 0.0002
Brugia malayi Importin beta-1 subunit 0.0028 0.0000089181 0.0000089181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0017 0.0017
Trypanosoma brucei calpain, putative 0.0512 0.076 0.2216
Loa Loa (eye worm) hypothetical protein 0.0728 0.11 0.11
Loa Loa (eye worm) hypothetical protein 0.3422 0.5331 0.5331
Trypanosoma brucei SIR2-like protein 4, putative 0.0032 0.0007 0.0019
Echinococcus granulosus tar DNA binding protein 0.0061 0.0053 0.0053
Brugia malayi Trypsin family protein 0.0059 0.0048 0.0048
Trichomonas vaginalis calmodulin, putative 0.027 0.0381 0.1106
Echinococcus multilocularis neuronal calcium sensor 0.027 0.0381 0.0381
Schistosoma mansoni chromatin regulatory protein sir2 0.0125 0.0152 0.0152
Brugia malayi PXA domain containing protein 0.0039 0.0017 0.0017
Onchocerca volvulus 0.0995 0.1519 0.3356
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0643 0.0966 0.2817
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.4925 0.7691 0.7691
Echinococcus granulosus caspase 3 0.007 0.0067 0.0067
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.027 0.0381 0.1985
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0094 0.0094
Plasmodium falciparum plasmepsin VIII, putative 0.0029 0.0002 0.0011
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0032 0.0007 0.0042
Entamoeba histolytica grainin 2 0.0284 0.0403 0.21
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Leishmania major calmodulin-like protein 0.027 0.0381 0.1094
Echinococcus multilocularis glycoprotein Antigen 5 0.0059 0.0048 0.0048
Loa Loa (eye worm) animal heme peroxidase 0.0325 0.0466 0.0466
Onchocerca volvulus Deterin homolog 0.0041 0.002 0.0044
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0512 0.076 0.0754
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0017 0.0017
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0035 0.0028
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.01 0.01
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0017 0.0017
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.4655 0.7267 0.7267
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0015 0.0015
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0125 0.0152 0.0145
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0015 0.004
Leishmania major proteasome beta 5 subunit, putative 0.0155 0.02 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0336 0.0485 0.1409
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0046 0.0028 0.0116
Brugia malayi TAR-binding protein 0.0061 0.0053 0.0053
Plasmodium falciparum plasmepsin I 0.0029 0.0002 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0995 0.1519 0.4429
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0017 0.0017
Leishmania major protein kinase, putative 0.027 0.0381 0.1094
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0017 0.0017
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0138 0.0173 0.0499
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0151 0.0151
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0151 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.076 0.2212
Echinococcus granulosus cathepsin L cysteine protease 0.0604 0.0904 0.0904
Brugia malayi Blistered cuticle protein 3 0.0325 0.0466 0.0466
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0035 0.0012 0.0005
Giardia lamblia GPI-anchor transamidase, putative 0.0035 0.0012 0.0015
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0512 0.076 0.0754
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Echinococcus granulosus cysteine protease 0.0604 0.0904 0.0904
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0015 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Plasmodium falciparum plasmepsin III 0.0029 0.0002 0.0011
Echinococcus granulosus prolyl endopeptidase 0.1596 0.2463 0.2462
Loa Loa (eye worm) calmodulin-like protein 0.027 0.0381 0.0381
Trypanosoma brucei calpain-like protein, putative 0.1745 0.2696 0.7866
Loa Loa (eye worm) calpain family protein 1 0.3422 0.5331 0.5331
Loa Loa (eye worm) calpain D 0.0512 0.076 0.076
Onchocerca volvulus 0.0059 0.0048 0.0106
Onchocerca volvulus 0.0995 0.1519 0.3356
Trypanosoma cruzi I/6 autoantigen, putative 0.027 0.0381 0.0375
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0017 0.0045
Entamoeba histolytica calcium binding family protein 0.027 0.0381 0.1985
Schistosoma mansoni chromatin regulatory protein sir2 0.0032 0.0007 0.0007
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0512 0.076 0.2216
Echinococcus multilocularis centrin 2 0.027 0.0381 0.0381
Brugia malayi Trypsin-like protease protein 5 0.0059 0.0048 0.0048
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0138 0.0173 0.0173
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0071 0.0067 0.0443
Trypanosoma cruzi cysteine peptidase, putative 0.0604 0.0904 0.0898
Entamoeba histolytica grainin, putative 0.0274 0.0387 0.2018
Loa Loa (eye worm) hypothetical protein 0.2911 0.4527 0.4527
Brugia malayi Kelch motif family protein 0.0046 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Leishmania major centrin, putative,caltractin, putative 0.027 0.0381 0.1094
Echinococcus granulosus Mastin 0.0059 0.0048 0.0048
Schistosoma mansoni memapsin-2 (A01 family) 0.0449 0.0661 0.0661
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0138 0.0138
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.027 0.0381 0.1111
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Onchocerca volvulus Cathepsin L homolog 0.0336 0.0485 0.1071
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0512 0.076 0.0754
Onchocerca volvulus 0.0274 0.0387 0.0855
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0602 0.0901 0.0901
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0015 0.004
Schistosoma mansoni calpain-7 (C02 family) 0.1748 0.2701 0.2701
Plasmodium vivax aspartyl protease, putative 0.011 0.0129 0.0478
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0071 0.0067 0.0191
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1745 0.2696 0.2691
Schistosoma mansoni cercarial elastase (S01 family) 0.0059 0.0048 0.0048
Echinococcus multilocularis neurocalcin 0.027 0.0381 0.0381
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.2202
Echinococcus multilocularis calmodulin 0.027 0.0381 0.0381
Brugia malayi calpain 7 0.1745 0.2696 0.2696
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.027 0.0381 0.0381
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0643 0.0966 1
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.0337 0.0337
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0045
Brugia malayi Cytochrome P450 family protein 0.0032 0.0007 0.0007
Schistosoma mansoni chromatin regulatory protein sir2 0.0125 0.0152 0.0152
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.027 0.0381 0.1985
Schistosoma mansoni hemoglobinase (C13 family) 0.0152 0.0196 0.0196
Trichomonas vaginalis calmodulin, putative 0.027 0.0381 0.1106
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Echinococcus granulosus centrin 2 0.027 0.0381 0.0381
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Brugia malayi cathepsin Z-like cysteine proteinase 0.0336 0.0485 0.0485
Toxoplasma gondii histone deacetylase SIR2-like 0.0032 0.0007 0.0019
Trichomonas vaginalis myosin light chain 1, putative 0.027 0.0381 0.1106
Echinococcus granulosus proteasome prosome macropain 0.0155 0.02 0.02
Onchocerca volvulus 0.0031 0.0005 0.0011
Leishmania major centrin, putative 0.027 0.0381 0.1094
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0029 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0267 0.0376 0.0376
Echinococcus multilocularis cathepsin L cysteine protease 0.0995 0.1519 0.1519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0604 0.0904 0.2634
Schistosoma mansoni microtubule-associated protein tau 0.1403 0.2159 0.2159
Brugia malayi programmed cell death protein 6 0.027 0.0381 0.0381
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.027 0.0381 0.0375
Trypanosoma brucei oligopeptidase b 0.0643 0.0966 0.2817
Entamoeba histolytica GPI-anchor transamidase, putative 0.0035 0.0012 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0274 0.0387 0.1435
Leishmania major cathepsin L-like protease 0.0995 0.1519 0.4422
Plasmodium falciparum serine repeat antigen 4 0.0336 0.0485 0.319
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.01 0.0292
Brugia malayi calpain D 0.0512 0.076 0.076
Plasmodium vivax aspartyl protease, putative 0.011 0.0129 0.0478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0031 0.0031
Echinococcus granulosus calmodulin 0.027 0.0381 0.0381
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0223 0.0306 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0045
Trypanosoma cruzi cysteine protease, putative 0.0604 0.0904 0.0898
Loa Loa (eye worm) integrin beta-2 0.0306 0.0437 0.0437
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0155 0.02 0.0891
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0125 0.0152 0.0152
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0274 0.0387 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.027 0.0381 0.1106
Toxoplasma gondii centrin, putative 0.027 0.0381 0.1111
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0512 0.076 0.2216
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0125 0.0152 0.0152
Trypanosoma brucei proteasome beta 6 subunit 0.0071 0.0067 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0015 0.0009
Trypanosoma cruzi oligopeptidase b 0.0643 0.0966 0.096
Loa Loa (eye worm) hypothetical protein 0.0336 0.0485 0.0485
Plasmodium vivax aspartyl proteinase, putative 0.0029 0.0002 0.0006
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0196 0.0565
Trichomonas vaginalis calmodulin, putative 0.027 0.0381 0.1106
Echinococcus multilocularis cysteine protease 0.0995 0.1519 0.1519
Trypanosoma cruzi cysteine peptidase, putative 0.1091 0.1669 0.1664
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0334 0.0481 0.0481
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0995 0.1519 1
Schistosoma mansoni caspase-7 (C14 family) 0.0096 0.0107 0.0107
Plasmodium vivax aspartyl protease, putative 0.0029 0.0002 0.0006
Plasmodium vivax GPI-anchor transamidase, putative 0.0035 0.0012 0.0043
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0015 0.0015
Echinococcus multilocularis peroxidasin 0.0325 0.0466 0.0466
Entamoeba histolytica cysteine proteinase 2 0.0604 0.0904 0.4759
Echinococcus granulosus integrin alpha ps 0.0067 0.0061 0.0061
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0014 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0336 0.0485 0.0485
Giardia lamblia Cathepsin B precursor 0.0336 0.0485 0.1398
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0059 0.0048 0.0048
Trypanosoma brucei caltractin, putative 0.0284 0.0403 0.1174
Brugia malayi Animal haem peroxidase family protein 0.0325 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.027 0.0381 0.0381
Schistosoma mansoni cathepsin C 0.0336 0.0485 0.0485
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0196 0.0565
Giardia lamblia Cathepsin L precursor 0.0336 0.0485 0.1398
Entamoeba histolytica cysteine protease, putative 0.0604 0.0904 0.4759
Trypanosoma brucei calpain-like protein, putative 0.1745 0.2696 0.7866
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0046 0.0028 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0336 0.0485 0.1409
Loa Loa (eye worm) hypothetical protein 0.0028 0.0000089181 0.0000089181
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0048 0.0048
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0029 0.0002 0.0002
Leishmania major calmodulin-like protein 0.027 0.0381 0.1094
Toxoplasma gondii aspartyl protease ASP3 0.011 0.0129 0.0376
Schistosoma mansoni hypothetical protein 0.0512 0.076 0.076
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0014 0.0093
Entamoeba histolytica cysteine proteinase, putative 0.0728 0.11 0.5797
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.2691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0155 0.02 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0238 0.0689
Leishmania major phospholipase c-like protein 0.027 0.0381 0.1094
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0017 0.0045
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0134 0.0134
Echinococcus multilocularis caspase 3 0.007 0.0067 0.0067
Brugia malayi Cathepsin L-like precursor 0.0267 0.0376 0.0376
Schistosoma mansoni cathepsin D (A01 family) 0.0124 0.015 0.015
Trypanosoma cruzi 20S proteasome subunit 0.0046 0.0028 0.0022
Mycobacterium tuberculosis Conserved protein 0.0038 0.0015 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0995 0.1519 0.4429
Echinococcus multilocularis calumenin 0.0274 0.0387 0.0387
Brugia malayi hypothetical protein 0.0039 0.0017 0.0017
Loa Loa (eye worm) blistered cuticle protein 3 0.0325 0.0466 0.0466
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0151 0.0151
Onchocerca volvulus Cathepsin F homolog 0.0995 0.1519 0.3356
Brugia malayi aspartic protease BmAsp-2, identical 0.0029 0.0002 0.0002
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.4925 0.7691 0.7691
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0011
Loa Loa (eye worm) sirtuin 4 0.0032 0.0007 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0151 0.0664
Entamoeba histolytica hypothetical protein, conserved 0.0179 0.0238 0.1226
Brugia malayi cathepsin F-like cysteine proteinase 0.0336 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0512 0.076 0.2212
Entamoeba histolytica hypothetical protein 0.0039 0.0017 0.0058
Echinococcus granulosus chromatin regulatory protein sir2 0.0125 0.0152 0.0152
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0015 0.0039
Trypanosoma cruzi centrin-3 0.0284 0.0403 0.0396
Onchocerca volvulus 0.005 0.0034 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1091 0.1669 0.487
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0336 0.0485 0.0485
Brugia malayi Peroxidasin 0.0325 0.0466 0.0466
Trichomonas vaginalis centrin, putative 0.027 0.0381 0.1106
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.7862
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0604 0.0904 0.0904
Entamoeba histolytica calmodulin, putative 0.027 0.0381 0.1985
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.6395 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0012 0.0029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0512 0.076 0.0754
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0053 0.0053
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0643 0.0966 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0223 0.0306 0.0299
Trypanosoma brucei mitochondrial calcium uptake 1 0.027 0.0381 0.1111
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0238 0.0231
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.0416 0.1213
Trypanosoma cruzi cysteine peptidase, putative 0.0995 0.1519 0.1514
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1745 0.2696 0.7866
Onchocerca volvulus Peroxidasin homolog 0.0325 0.0466 0.103
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0336 0.0485 0.1409

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.3 uM Inhibition of ovine Prostaglandin G/H synthase 2 ChEMBL. 15267236
IC50 (binding) = 1.3 uM Inhibition of ovine Prostaglandin G/H synthase 2 ChEMBL. 15267236
IC50 (binding) > 100 uM Inhibition of ovine Prostaglandin G/H synthase 1 ChEMBL. 15267236
IC50 (binding) > 100 uM Inhibition of ovine Prostaglandin G/H synthase 1 ChEMBL. 15267236
SI (binding) > 77 In vitro selectivity for Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ChEMBL. 15267236
SI (binding) > 77 In vitro selectivity for Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ChEMBL. 15267236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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