TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 866.908 | Formula: C46H50N4O13
H donors: 3 H acceptors: 4 LogP: 6.71 Rotable bonds: 24
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@H](NC(=O)OCc1ccccc1)CCCNNC(=O)c1c(c2ccc(c(c2)OC)OC)c2c(n1CCc1ccc(c(c1)OC)OC)c(=O)oc1c2cc(OC)c(c1)OC
InChi: 1S/C46H50N4O13/c1-55-32-17-15-27(22-35(32)57-3)19-21-50-41(43(51)49-47-20-11-14-31(44(52)61-7)48-46(54)62-26-28-12-9-8-10-13-28)39(29-16-18-33(56-2)36(23-29)58-4)40-30-24-37(59-5)38(60-6)25-34(30)63-45(53)42(40)50/h8-10,12-13,15-18,22-25,31,47H,11,14,19-21,26H2,1-7H3,(H,48,54)(H,49,51)/t31-/m0/s1
InChiKey: KOSOWHMTEHSODT-HKBQPEDESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0578	0.106	0.2465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3718	0.7287	0.7287
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0012	0.0035
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.079	0.148	0.148
Echinococcus multilocularis	EF hand domain containing family member A2	0.0203	0.0316	0.0316
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0151	0.0212	0.1121
Trichomonas vaginalis	hypothetical protein	0.0382	0.0671	0.1975
Loa Loa (eye worm)	animal heme peroxidase	0.0129	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0578	0.106	0.106
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0201	0.031	0.031
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0093	0.0098	0.0287
Trypanosoma cruzi	oligopeptidase b	0.0353	0.0613	0.0613
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.2521
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0003	0.0003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Echinococcus multilocularis	calpain family protein 1, d	0.2585	0.5039	0.5039
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0382	0.0671	0.0671
Giardia lamblia	Cathepsin L precursor	0.0267	0.0443	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0578	0.106	0.106
Onchocerca volvulus		0.079	0.148	0.3449
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0353	0.0613	0.1804
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5086	1	1
Trichomonas vaginalis	centrin, putative	0.0201	0.031	0.0913
Trichomonas vaginalis	calmodulin, putative	0.0201	0.031	0.0913
Giardia lamblia	Cysteine protease	0.0267	0.0443	0.1304
Echinococcus multilocularis	calbindin 32	0.0203	0.0316	0.0316
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0267	0.0443	0.0443
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0012	0.0035
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0669	0.1241	0.1241
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0888	0.1674	0.4924
Giardia lamblia	Cathepsin L precursor	0.0267	0.0443	0.1304
Entamoeba histolytica	calmodulin, putative	0.0201	0.031	0.176
Loa Loa (eye worm)	blistered cuticle protein 3	0.0129	0.017	0.017
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0267	0.0443	0.1757
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0353	0.0613	0.1804
Entamoeba histolytica	cysteine proteinase 2	0.0479	0.0864	0.4896
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0093	0.0098	0.0287
Onchocerca volvulus		0.0129	0.017	0.0382
Trypanosoma brucei	calmodulin, putative	0.0203	0.0316	0.093
Echinococcus multilocularis	centrin 2	0.0201	0.031	0.031
Giardia lamblia	Cathepsin L precursor	0.0267	0.0443	0.1304
Giardia lamblia	Cathepsin L precursor	0.0267	0.0443	0.1304
Loa Loa (eye worm)	ctsf protein	0.079	0.148	0.148
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0353	0.0613	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Toxoplasma gondii	calcium-dependent protein kinase	0.0204	0.0317	0.0933
Giardia lamblia	Cathepsin B precursor	0.1758	0.3399	1
Trypanosoma brucei	calpain-like protein, putative	0.1315	0.2521	0.7419
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0093	0.0098	0.0553
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0267	0.0443	0.1304
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0201	0.031	0.031
Trypanosoma cruzi	kinesin, putative	0.0933	0.1763	0.1763
Echinococcus multilocularis	calmodulin	0.0201	0.031	0.031
Leishmania major	hypothetical protein, unknown function	0.0382	0.0671	0.1975
Plasmodium vivax	hypothetical protein, conserved	0.0093	0.0098	0.0387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Trypanosoma brucei	oligopeptidase b	0.0353	0.0613	0.1804
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0098	0.0098
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0267	0.0443	0.2993
Echinococcus granulosus	programmed cell death protein	0.0209	0.0327	0.0327
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0151	0.0212	0.0212
Schistosoma mansoni	cathepsin F (C01 family)	0.079	0.148	0.148
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1315	0.2521	0.2521
Leishmania major	programmed cell death 6 protein-like protein	0.0201	0.031	0.0913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Trypanosoma cruzi	calmodulin, putative	0.0201	0.031	0.031
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0212	0.0333	0.0333
Giardia lamblia	Hypothetical protein	0.0267	0.0443	0.1304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0267	0.0443	0.0443
Brugia malayi	Cathepsin L-like precursor	0.079	0.148	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.079	0.148	0.4355
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0353	0.0613	0.1804
Brugia malayi	Cathepsin L-like precursor	0.0578	0.106	0.106
Brugia malayi	proteasome subunit beta type 1	0.0068	0.0047	0.0047
Echinococcus granulosus	microtubule associated protein 2	0.1336	0.2563	0.2563
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Entamoeba histolytica	hypothetical protein, conserved	0.0093	0.0098	0.0553
Giardia lamblia	Cathepsin B precursor	0.0267	0.0443	0.1304
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0267	0.0443	0.1757
Leishmania major	i/6 autoantigen-like protein	0.0201	0.031	0.0913
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.7419
Schistosoma mansoni	centrin	0.0201	0.031	0.031
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Plasmodium vivax	unspecified product	0.0479	0.0864	0.3425
Echinococcus multilocularis	cathepsin L cysteine protease	0.079	0.148	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0267	0.0443	0.1304
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.0443	0.1304
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0267	0.0443	0.1757
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0093	0.0098	0.0098
Trypanosoma cruzi	cysteine peptidase, putative	0.0479	0.0864	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0028	0.0028
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.1315	0.2521	0.7419
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0068	0.0047	0.0047
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0382	0.0671	0.1975
Schistosoma mansoni	peroxidasin	0.0129	0.017	0.017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0003	0.0003
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Loa Loa (eye worm)	calpain	0.1315	0.2521	0.2521
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0012	0.0012
Trypanosoma brucei	hypothetical protein	0.0382	0.0671	0.1975
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.5086	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0267	0.0443	0.0443
Trichomonas vaginalis	calmodulin, putative	0.0201	0.031	0.0913
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0028	0.0028
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0012	0.0012
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0151	0.0212	0.0212
Echinococcus granulosus	EF hand domain containing family member A2	0.0201	0.031	0.031
Loa Loa (eye worm)	calpain family protein 1	0.2585	0.5039	0.5039
Brugia malayi	Papain family cysteine protease containing protein	0.0267	0.0443	0.0443
Onchocerca volvulus	Cathepsin F homolog	0.079	0.148	0.3449
Trichomonas vaginalis	peptide N-glycanase, putative	0.007	0.0051	0.015
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0353	0.0613	0.0613
Loa Loa (eye worm)	hypothetical protein	0.2585	0.5039	0.5039
Schistosoma mansoni	calpain C (C02 family)	0.1315	0.2521	0.2521
Leishmania major	hypothetical protein, conserved	0.0203	0.0316	0.093
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Entamoeba histolytica	protein kinase, putative	0.0933	0.1764	1
Toxoplasma gondii	proteasome subunit beta type, putative	0.0151	0.0212	0.0624
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0267	0.0443	0.0443
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0267	0.0443	0.2512
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0382	0.0671	0.0671
Trichomonas vaginalis	conserved hypothetical protein	0.0382	0.0671	0.1975
Trypanosoma cruzi	cysteine protease, putative	0.0479	0.0864	0.0864
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Entamoeba histolytica	cysteine proteinase, putative	0.0479	0.0864	0.4896
Trypanosoma cruzi	conserved protein	0.0382	0.0671	0.0671
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0382	0.0671	0.1975
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0933	0.1763	0.9995
Leishmania major	calmodulin, putative	0.0201	0.031	0.0913
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0267	0.0443	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0333	0.0333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.0864	0.2541
Giardia lamblia	Encystation-specific protease	0.0267	0.0443	0.1304
Brugia malayi	Pre-SET motif family protein	0.0058	0.0028	0.0028
Plasmodium falciparum	peptidase, putative	0.0093	0.0098	0.0659
Trypanosoma cruzi	major cysteine proteinase, putative	0.0359	0.0624	0.0624
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0008	0.0008
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0093	0.0098	0.0287
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0006	0.0006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0028	0.0028
Trypanosoma brucei	centrin, putative	0.0201	0.031	0.0913
Echinococcus multilocularis	cysteine protease	0.079	0.148	0.148
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0267	0.0443	0.2993
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0201	0.0311	0.0311
Onchocerca volvulus		0.079	0.148	0.3449
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Loa Loa (eye worm)	calpain D	0.0382	0.0671	0.0671
Schistosoma mansoni	calmodulin related calcium binding protein	0.0201	0.031	0.031
Brugia malayi	Cathepsin L-like precursor	0.079	0.148	0.148
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.2521
Echinococcus multilocularis	prolyl endopeptidase	0.0888	0.1674	0.1674
Brugia malayi	cathepsin F-like cysteine proteinase	0.0267	0.0443	0.0443
Plasmodium falciparum	serine repeat antigen 5	0.0267	0.0443	0.2993
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0012	0.0012
Brugia malayi	calpain family protein 1	0.3518	0.6889	0.6889
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0093	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0098	0.0098
Entamoeba histolytica	cysteine proteinase, putative	0.0578	0.106	0.6009
Echinococcus multilocularis	calpain 7 (C02 family)	0.1315	0.2521	0.2521
Loa Loa (eye worm)	cysteine protease	0.079	0.148	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0479	0.0864	0.2541
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Brugia malayi	Papain family cysteine protease containing protein	0.0267	0.0443	0.0443
Brugia malayi	Cathepsin L-like precursor	0.079	0.148	0.148
Trypanosoma cruzi	centrin-3	0.0209	0.0327	0.0327
Trichomonas vaginalis	calmodulin, putative	0.0201	0.031	0.0913
Trichomonas vaginalis	calmodulin, putative	0.0201	0.031	0.0913
Trypanosoma brucei	calmodulin, putative	0.0201	0.031	0.0913
Brugia malayi	calpain 7	0.1315	0.2521	0.2521
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0151	0.0212	0.0842
Loa Loa (eye worm)	prolyl oligopeptidase	0.0093	0.0098	0.0098
Echinococcus granulosus	calmodulin	0.0201	0.031	0.031
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0382	0.0671	0.1975
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0254	0.0416	0.0416
Plasmodium vivax	vivapain-1	0.0479	0.0864	0.3425
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0012	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0382	0.0671	0.0671
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1758	0.3399	1
Entamoeba histolytica	calcium binding family protein	0.0201	0.031	0.176
Onchocerca volvulus		0.0146	0.0203	0.046
Loa Loa (eye worm)	EF hand family protein	0.0201	0.031	0.031
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0012	0.0012
Trypanosoma cruzi	hypothetical protein, conserved	0.0093	0.0098	0.0098
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0201	0.031	0.031
Brugia malayi	Thioredoxin family protein	0.007	0.0051	0.0051
Trypanosoma brucei	protein I/6	0.0201	0.031	0.0913
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Trichomonas vaginalis	calmodulin, putative	0.0203	0.0316	0.093
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0093	0.0098	0.0098
Leishmania major	kinesin, putative	0.0933	0.1763	0.5187
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0118	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Toxoplasma gondii	EF hand domain-containing protein	0.0201	0.031	0.0913
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Plasmodium vivax	serine-repeat antigen (SERA)	0.0267	0.0443	0.1757
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3718	0.7287	0.7287
Brugia malayi	EF hand family protein	0.0201	0.031	0.031
Leishmania major	calpain protease-like protein	0.0382	0.0671	0.1975
Plasmodium vivax	vivapain-2	0.079	0.148	0.5871
Brugia malayi	Cathepsin L-like precursor	0.079	0.148	0.148
Echinococcus granulosus	cathepsin L	0.0267	0.0443	0.0443
Brugia malayi	Calmodulin-like protein	0.0201	0.031	0.031
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0201	0.031	0.0913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0479	0.0864	0.0864
Toxoplasma gondii	EFHC1, putative	0.0201	0.031	0.0913
Schistosoma mansoni	ef hand domain family member A2	0.0201	0.031	0.031
Echinococcus multilocularis	cathepsin L cysteine protease	0.079	0.148	0.148
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0382	0.0671	0.1975
Trypanosoma cruzi	prolyl endopeptidase	0.0888	0.1674	0.1674
Trypanosoma brucei	Calpain-like protein 2	0.0382	0.0671	0.1975
Brugia malayi	hypothetical protein	0.0129	0.017	0.017
Schistosoma mansoni	rab	0.0201	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0443	0.0443
Giardia lamblia	Transglutaminase/protease, putative	0.007	0.0051	0.015
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0267	0.0443	0.1757
Brugia malayi	calcium-binding protein	0.0201	0.031	0.031
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0068	0.0047	0.0267
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0093	0.0098	0.0098
Brugia malayi	prolyl oligopeptidase family protein	0.0093	0.0098	0.0098
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0267	0.0443	0.1304
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0201	0.0311	0.1235
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0405	0.0716	0.0716
Loa Loa (eye worm)	animal heme peroxidase	0.0129	0.017	0.017
Trypanosoma brucei	protein kinase, putative	0.005	0.0012	0.0035
Plasmodium falciparum	serine repeat antigen 2	0.0267	0.0443	0.2993
Trypanosoma brucei	proteasome beta 6 subunit	0.0068	0.0047	0.0138
Onchocerca volvulus		0.0129	0.017	0.0382
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0267	0.0443	0.1304
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.079	0.148	1
Mycobacterium ulcerans	proteasome PrcB	0.0151	0.0212	0.2868
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0012	0.0035
Onchocerca volvulus		0.0203	0.0316	0.0725
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0267	0.0443	0.0443
Leishmania major	protein kinase, putative	0.0201	0.0311	0.0916
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trichomonas vaginalis	calmodulin, putative	0.0201	0.031	0.0913
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Brugia malayi	Animal haem peroxidase family protein	0.0129	0.017	0.017
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0093	0.0098	0.0098
Entamoeba histolytica	cysteine proteinase, putative	0.0479	0.0864	0.4896
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0151	0.0212	0.1203
Trypanosoma cruzi	calmodulin, putative	0.0201	0.031	0.031
Onchocerca volvulus	Dual oxidase homolog	0.0129	0.017	0.0382
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0201	0.031	0.0913
Echinococcus multilocularis	hypothetical protein	0.1315	0.2521	0.2521
Plasmodium vivax	SET domain protein, putative	0.0058	0.0028	0.0111
Onchocerca volvulus		0.0129	0.017	0.0382
Brugia malayi	MAP kinase sur-1	0.005	0.0012	0.0012
Trypanosoma cruzi	cysteine proteinase, putative	0.0479	0.0864	0.0864
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Echinococcus multilocularis	peroxidasin	0.0129	0.017	0.017
Plasmodium falciparum	proteasome subunit beta type-5	0.0151	0.0212	0.1434
Trypanosoma brucei	calpain-like protein, putative	0.1315	0.2521	0.7419
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0382	0.0671	0.0671
Plasmodium falciparum	calpain	0.0382	0.0671	0.4535
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Onchocerca volvulus	Cathepsin L homolog	0.0267	0.0443	0.1022
Schistosoma mansoni	microtubule-associated protein tau	0.1336	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0333	0.0333
Trypanosoma cruzi	cysteine peptidase, putative	0.0882	0.1661	0.1661
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0012	0.0012
Giardia lamblia	Cathepsin B precursor	0.0267	0.0443	0.1304
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0201	0.031	0.031
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Echinococcus granulosus	cathepsin b	0.5086	1	1
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0093	0.0098	0.0287
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.0371	0.0371
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Schistosoma mansoni	neuronal calcium sensor	0.0201	0.031	0.031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0003	0.0003
Echinococcus multilocularis	tumor protein p63	0.0327	0.0562	0.0562
Leishmania major	hypothetical protein, conserved	0.0201	0.031	0.0913
Echinococcus multilocularis	programmed cell death protein	0.0209	0.0327	0.0327
Echinococcus multilocularis	calpain 5	0.1315	0.2521	0.2521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Onchocerca volvulus		0.2202	0.428	1
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0068	0.0047	0.0186
Echinococcus granulosus	calpain 5	0.1315	0.2521	0.2521
Plasmodium vivax	hypothetical protein, conserved	0.0203	0.0316	0.1254
Echinococcus granulosus	cathepsin L cysteine protease	0.0479	0.0864	0.0864
Plasmodium vivax	centrin-1, putative	0.0201	0.031	0.1231
Brugia malayi	calpain D	0.0382	0.0671	0.0671
Loa Loa (eye worm)	hypothetical protein	0.3135	0.6131	0.6131
Echinococcus multilocularis	calmodulin	0.0201	0.031	0.031
Brugia malayi	Papain family cysteine protease containing protein	0.0267	0.0443	0.0443
Trypanosoma brucei	Calpain-like protein 1.1	0.0382	0.0671	0.1975
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0058	0.0028	0.0028
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.7419
Entamoeba histolytica	grainin, putative	0.0203	0.0316	0.1792
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0118	0.0147	0.0433
Entamoeba histolytica	cysteine proteinase, putative	0.079	0.148	0.8393
Trypanosoma cruzi	caltractin, putative	0.0201	0.031	0.031
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.0147	0.0147
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0093	0.0098	0.0287
Trypanosoma cruzi	calmodulin, putative	0.0201	0.031	0.031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Leishmania major	centrin, putative	0.0201	0.031	0.0913
Schistosoma mansoni	centrin-related	0.0201	0.031	0.031
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0012	0.0012
Echinococcus multilocularis	cathepsin L	0.0479	0.0864	0.0864
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0382	0.0671	0.0671
Brugia malayi	Blistered cuticle protein 3	0.0129	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.0888	0.1674	0.1674
Schistosoma mansoni	cathepsin B (C01 family)	0.0267	0.0443	0.0443
Echinococcus granulosus	cathepsin b	0.5086	1	1
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0068	0.0047	0.0047
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0151	0.0212	0.0212
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0267	0.0443	0.1757
Echinococcus granulosus	cathepsin L	0.0479	0.0864	0.0864
Plasmodium vivax	calpain, putative	0.1315	0.2521	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0147	0.171
Plasmodium falciparum	serine repeat antigen 7	0.0267	0.0443	0.2993
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0151	0.0212	0.0624
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trypanosoma cruzi	centrin, putative	0.0209	0.0327	0.0327
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0068	0.0047	0.0047
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0093	0.0098	0.0287
Echinococcus granulosus	gamma secretase subunit aph 1	0.0254	0.0416	0.0416
Trypanosoma cruzi	I/6 autoantigen, putative	0.0201	0.031	0.031
Brugia malayi	calpain 5	0.0933	0.1763	0.1763
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3518	0.6889	0.6889
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0068	0.0047	0.0138
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Trypanosoma brucei	I/6 autoantigen	0.0201	0.031	0.0913
Leishmania major	cathepsin L-like protease	0.079	0.148	0.4355
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0382	0.0671	0.1975
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0093	0.0098	0.0553
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Trypanosoma brucei	hypothetical protein, conserved	0.0201	0.031	0.0913
Echinococcus multilocularis	calumenin	0.0203	0.0316	0.0316
Giardia lamblia	Cathepsin L precursor	0.0267	0.0443	0.1304
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0267	0.0443	0.1304
Trichomonas vaginalis	calcium binding protein, putative	0.0201	0.031	0.0913
Echinococcus granulosus	acylamino acid releasing enzyme	0.0093	0.0098	0.0098
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0012	0.0035
Onchocerca volvulus	Peroxidasin homolog	0.0129	0.017	0.0382
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.3718	0.7287	0.7287
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Echinococcus granulosus	proteasome prosome macropain	0.0151	0.0212	0.0212
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Leishmania major	cathepsin L-like protease	0.079	0.148	0.4355
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0003	0.0003
Trichomonas vaginalis	calcineurin B subunit, putative	0.0203	0.0316	0.093
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1315	0.2521	0.2521
Echinococcus multilocularis	neurocalcin	0.0201	0.031	0.031
Brugia malayi	Cathepsin L-like precursor	0.079	0.148	0.148
Plasmodium vivax	vivapain-2	0.079	0.148	0.5871
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0267	0.0443	0.1304
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0006	0.0006
Loa Loa (eye worm)	animal heme peroxidase	0.0129	0.017	0.017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0267	0.0443	0.1304
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0382	0.0671	0.1975
Loa Loa (eye worm)	calmodulin-like protein	0.0201	0.031	0.031
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0093	0.0098	0.0553
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Trypanosoma cruzi	hypothetical protein, conserved	0.0093	0.0098	0.0098
Schistosoma mansoni	Mername-AA248 (C02 family)	0.1315	0.2521	0.2521
Brugia malayi	prolyl oligopeptidase family protein	0.0093	0.0098	0.0098
Leishmania major	hypothetical protein, conserved	0.0382	0.0671	0.1975
Loa Loa (eye worm)	hypothetical protein	0.0578	0.106	0.106
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0267	0.0443	0.1304
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0382	0.0671	0.0671
Trypanosoma cruzi	oligopeptidase b	0.0353	0.0613	0.0613
Schistosoma mansoni	hypothetical protein	0.0201	0.031	0.031
Leishmania major	cathepsin L-like protease	0.079	0.148	0.4355
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0443	0.0443
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0267	0.0443	0.2993
Echinococcus granulosus	cysteine protease	0.0479	0.0864	0.0864
Trypanosoma brucei	antigen, putative	0.1315	0.2521	0.7419
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0267	0.0443	0.1757
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0267	0.0443	0.0443
Entamoeba histolytica	cysteine protease, putative	0.0267	0.0443	0.2512
Toxoplasma gondii	cathepsin CPL	0.079	0.148	0.4355
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0047	0.0138
Trichomonas vaginalis	calmodulin-2, putative	0.0201	0.031	0.0913
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0212	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0382	0.0671	0.0671
Trichomonas vaginalis	calmodulin, putative	0.0201	0.031	0.0913
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0267	0.0443	0.1304
Toxoplasma gondii	cathepsin CPC2	0.0267	0.0443	0.1304
Schistosoma mansoni	cathepsin s	0.0212	0.0333	0.0333
Leishmania major	calmodulin-like protein	0.0201	0.031	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0443	0.0443
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0003	0.0003
Echinococcus granulosus	cathepsin l cysteine peptidase	0.079	0.148	0.148
Toxoplasma gondii	cathepsin CPC1	0.0267	0.0443	0.1304
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0203	0.0316	0.0316
Toxoplasma gondii	hypothetical protein	0.0382	0.0671	0.1975
Echinococcus multilocularis	EF hand domain containing family member A2	0.0201	0.031	0.031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Trichomonas vaginalis	calcium binding proteins, putative	0.0201	0.031	0.0913
Onchocerca volvulus		0.079	0.148	0.3449
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0012	0.0035
Plasmodium falciparum	serine repeat antigen 8	0.0267	0.0443	0.2993
Trichomonas vaginalis	calpain, putative	0.0382	0.0671	0.1975
Echinococcus granulosus	cathepsin l1	0.079	0.148	0.148
Trypanosoma cruzi	cruzipain precursor, putative	0.0212	0.0333	0.0333
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.079	0.148	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Entamoeba histolytica	cysteine proteinase, putative	0.0479	0.0864	0.4896
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0068	0.0047	0.0318
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0201	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0578	0.106	0.106
Plasmodium vivax	unspecified product	0.0267	0.0443	0.1757
Echinococcus multilocularis	cathepsin L	0.0267	0.0443	0.0443
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.7419
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0333	0.0333
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.079	0.148	0.148
Entamoeba histolytica	cysteine protease, putative	0.0267	0.0443	0.2512
Trichomonas vaginalis	calmodulin, putative	0.0201	0.031	0.0913
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.0047	0.0047
Brugia malayi	Cathepsin L-like precursor	0.0578	0.106	0.106
Echinococcus multilocularis	Transglutaminase	0.007	0.0051	0.0051
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0151	0.0212	0.2868
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0888	0.1674	0.1674
Trypanosoma brucei	centrin-3	0.0209	0.0327	0.0961
Brugia malayi	hypothetical protein	0.0231	0.0371	0.0371
Trypanosoma brucei	caltractin, putative	0.0209	0.0327	0.0961
Onchocerca volvulus		0.079	0.148	0.3449
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.079	0.148	0.8393
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0267	0.0443	0.1304
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.3718	0.7287	0.7287
Echinococcus multilocularis	microtubule associated protein 2	0.1336	0.2563	0.2563
Echinococcus multilocularis	neuronal calcium sensor	0.0201	0.031	0.031
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0093	0.0098	0.0287
Brugia malayi	prolyl oligopeptidase family protein	0.0093	0.0098	0.0098
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0068	0.0047	0.0138
Onchocerca volvulus	Peroxidasin homolog	0.0129	0.017	0.0382
Brugia malayi	Pre-SET motif family protein	0.0405	0.0716	0.0716
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0068	0.0047	0.0047
Toxoplasma gondii	hypothetical protein	0.0093	0.0098	0.0287
Loa Loa (eye worm)	hypothetical protein	0.2202	0.428	0.428
Plasmodium falciparum	centrin-1	0.0201	0.031	0.2097
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.0147	0.0147
Brugia malayi	gamma-secretase subunit aph-1	0.0254	0.0416	0.0416
Giardia lamblia	Proteasome subunit beta type 1	0.0068	0.0047	0.0138
Trichomonas vaginalis	conserved hypothetical protein	0.0201	0.031	0.0913
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0093	0.0098	0.0098
Giardia lamblia	Cathepsin B precursor	0.1758	0.3399	1
Giardia lamblia	Hypothetical protein	0.007	0.0051	0.015
Trypanosoma brucei	calpain-like protein, putative	0.1315	0.2521	0.7419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.079	0.148	0.4355
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0353	0.0613	0.3908
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0382	0.0671	0.0671
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.0443	0.1304
Schistosoma mansoni	reticulocalbin	0.0203	0.0316	0.0316
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0003	0.0003
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0267	0.0443	0.1304
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0201	0.0311	0.0916
Trypanosoma brucei	calpain, putative	0.0382	0.0671	0.1975
Trypanosoma cruzi	cruzipain precursor, putative	0.0882	0.1661	0.1661
Trypanosoma brucei	Calpain-like protein 1.2	0.0382	0.0671	0.1975
Schistosoma mansoni	calpain-7 (C02 family)	0.1315	0.2521	0.2521
Leishmania major	oligopeptidase b	0.0353	0.0613	0.1804
Echinococcus granulosus	centrin 2	0.0201	0.031	0.031
Brugia malayi	prolyl oligopeptidase family protein	0.0888	0.1674	0.1674
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.0367	0.2196
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Plasmodium falciparum	serine repeat antigen 6	0.0267	0.0443	0.2993
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.079	0.148	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1315	0.2521	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Onchocerca volvulus		0.079	0.148	0.3449
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1315	0.2521	0.2521
Trichomonas vaginalis	calpain, putative	0.0382	0.0671	0.1975
Toxoplasma gondii	calmodulin CAM1	0.0203	0.0316	0.093
Entamoeba histolytica	cysteine protease, putative	0.0267	0.0443	0.2512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0267	0.0443	0.1304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Brugia malayi	cathepsin F-like cysteine proteinase	0.0212	0.0333	0.0333
Onchocerca volvulus		0.079	0.148	0.3449
Trichomonas vaginalis	calpain, putative	0.0382	0.0671	0.1975
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.0098	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0578	0.106	0.3118
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0888	0.1674	0.3901
Brugia malayi	Cathepsin L-like precursor	0.079	0.148	0.148
Brugia malayi	Cathepsin L-like precursor	0.0212	0.0333	0.0333
Loa Loa (eye worm)	calpain family protein 1	0.3518	0.6889	0.6889
Brugia malayi	calpain family protein 1	0.3518	0.6889	0.6889
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Schistosoma mansoni	neuronal calcium sensor	0.0201	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0443	0.0443
Giardia lamblia	Cysteine protease	0.0267	0.0443	0.1304
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0093	0.0098	0.0287
Echinococcus multilocularis	cysteine protease	0.079	0.148	0.148
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Echinococcus multilocularis	expressed protein	0.0723	0.1346	0.1346
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0382	0.0671	0.1975
Entamoeba histolytica	calcium-binding protein, putative	0.0201	0.031	0.176
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0028	0.0028
Leishmania major	cathepsin L-like protease	0.079	0.148	0.4355
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0479	0.0864	0.2541
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0151	0.0212	0.0624
Onchocerca volvulus		0.0048	0.0008	0.0003
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0267	0.0443	0.1757
Toxoplasma gondii	aldehyde dehydrogenase	0.0118	0.0147	0.0433
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0201	0.031	0.0913
Plasmodium vivax	unspecified product	0.0212	0.0333	0.1322
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0012	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Schistosoma mansoni	cathepsin C	0.0267	0.0443	0.0443
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0267	0.0443	0.1304
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0267	0.0443	0.0443
Leishmania major	phospholipase c-like protein	0.0201	0.031	0.0913
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0267	0.0443	0.0443
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0151	0.0212	0.0212
Loa Loa (eye worm)	programmed cell death protein 6	0.0203	0.0316	0.0316
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.2521
Brugia malayi	EF hand family protein	0.0203	0.0316	0.0316
Echinococcus granulosus	prolyl endopeptidase	0.0888	0.1674	0.1674
Onchocerca volvulus		0.0461	0.0827	0.1921
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0201	0.031	0.031
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0003	0.0003
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0382	0.0671	0.1975
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0443	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0371	0.0371
Echinococcus multilocularis	programmed cell death protein	0.0209	0.0327	0.0327
Trypanosoma brucei	centrin, putative	0.0201	0.031	0.0913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.0443	0.1304
Giardia lamblia	Cathepsin L-like protease	0.0267	0.0443	0.1304
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0093	0.0098	0.0287
Trypanosoma cruzi	cysteine peptidase, putative	0.079	0.148	0.148
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0479	0.0864	0.0864
Entamoeba histolytica	hypothetical protein	0.0267	0.0443	0.2512
Giardia lamblia	Cathepsin B precursor	0.0267	0.0443	0.1304
Plasmodium falciparum	serine repeat antigen 9	0.0267	0.0443	0.2993
Brugia malayi	cathepsin L-like cysteine proteinase	0.0267	0.0443	0.0443
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5086	1	1
Leishmania major	cathepsin L-like protease	0.079	0.148	0.4355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.0864	0.2541
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0058	0.0028	0.0028
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Echinococcus granulosus	peroxidasin	0.0129	0.017	0.017
Plasmodium vivax	serine-repeat antigen (SERA)	0.0267	0.0443	0.1757
Echinococcus granulosus	calpain 7 C02 family	0.1315	0.2521	0.2521
Trypanosoma cruzi	Aph-1 protein, putative	0.0099	0.0109	0.0109
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0888	0.1674	0.1674
Toxoplasma gondii	cathepsin B	0.1758	0.3399	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Entamoeba histolytica	cysteine protease, putative	0.0267	0.0443	0.2512
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0058	0.0028	0.0082
Echinococcus granulosus	Transglutaminase	0.007	0.0051	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Entamoeba histolytica	calmodulin, putative	0.0201	0.031	0.176
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0382	0.0671	0.0671
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0151	0.0212	0.0624
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0093	0.0098	0.0098
Loa Loa (eye worm)	prolyl oligopeptidase	0.0093	0.0098	0.0098
Loa Loa (eye worm)	calpain 5	0.0933	0.1763	0.1763
Toxoplasma gondii	centrin	0.0201	0.031	0.0913
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0267	0.0443	0.1304
Onchocerca volvulus	Peroxidase homolog	0.0129	0.017	0.0382
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.7419
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.0201	0.031	0.031
Echinococcus granulosus	calumenin	0.0203	0.0316	0.0316
Schistosoma mansoni	memapsin-2 (A01 family)	0.0417	0.0739	0.0739
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0795	0.1489	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0382	0.0671	0.0671
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0012	0.0012
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0013	0.0013
Loa Loa (eye worm)	fibroinase	0.079	0.148	0.148
Leishmania major	cathepsin L-like protease	0.0882	0.1661	0.4887
Schistosoma mansoni	neuronal calcium sensor	0.0201	0.031	0.031
Schistosoma mansoni	calpain (C02 family)	0.1315	0.2521	0.2521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.0443	0.1304
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0267	0.0443	0.2512
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Trichomonas vaginalis	calcium binding protein, putative	0.0201	0.031	0.0913
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0267	0.0443	0.0443
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0201	0.0311	0.0311
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0093	0.0098	0.0098
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1315	0.2521	0.2521
Trichomonas vaginalis	conserved hypothetical protein	0.0201	0.031	0.0913
Leishmania major	calmodulin, putative	0.0201	0.031	0.0913
Mycobacterium tuberculosis	Probable peptidase	0.0353	0.0613	0.3908
Brugia malayi	Papain family cysteine protease containing protein	0.0479	0.0864	0.0864
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1315	0.2521	0.2521
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0201	0.031	0.176
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Leishmania major	cathepsin L-like protease	0.0882	0.1661	0.4887
Plasmodium falciparum	serine repeat antigen 4	0.0267	0.0443	0.2993
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0382	0.0671	0.1975
Plasmodium falciparum	cysteine proteinase falcipain 3	0.079	0.148	1
Schistosoma mansoni	mitochondrial solute carrier	0.0201	0.031	0.031
Schistosoma mansoni	cathepsin F (C01 family)	0.079	0.148	0.148
Toxoplasma gondii	prolyl endopeptidase	0.0888	0.1674	0.4924
Trichomonas vaginalis	centrin, putative	0.0201	0.031	0.0913
Onchocerca volvulus		0.0058	0.0028	0.0051
Echinococcus granulosus	cathepsin l1	0.0578	0.106	0.106
Schistosoma mansoni	cathepsin S (C01 family)	0.0267	0.0443	0.0443
Echinococcus granulosus	neuronal calcium sensor	0.0201	0.031	0.031
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0058	0.0028	0.0028
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0093	0.0098	0.0213
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Brugia malayi	programmed cell death protein 6	0.0201	0.031	0.031
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0267	0.0443	0.1304
Giardia lamblia	Cathepsin B precursor	0.0267	0.0443	0.1304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.0443	0.1304
Trypanosoma cruzi	I/6 autoantigen, putative	0.0201	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0008	0.0008
Leishmania major	calcineurin B subunit, putative	0.0201	0.031	0.0913
Schistosoma mansoni	calpain-7 (C02 family)	0.1315	0.2521	0.2521
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Leishmania major	centrin, putative,caltractin, putative	0.0201	0.031	0.0913
Schistosoma mansoni	hypothetical protein	0.0382	0.0671	0.0671
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Echinococcus granulosus	expressed protein	0.0723	0.1346	0.1346
Leishmania major	calpain family cysteine protease-like protein	0.0382	0.0671	0.1975
Leishmania major	cysteine peptidase A (CPA)	0.079	0.148	0.4355
Brugia malayi	Papain family cysteine protease containing protein	0.079	0.148	0.148
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Schistosoma mansoni	peroxidasin	0.0129	0.017	0.017
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0093	0.0098	0.0098
Trichomonas vaginalis	calcineurin B subunit, putative	0.0201	0.031	0.0913
Trypanosoma brucei	kinesin, putative	0.0933	0.1763	0.5187
Loa Loa (eye worm)	hypothetical protein	0.5086	1	1
Brugia malayi	fibroinase precursor	0.0267	0.0443	0.0443
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0382	0.0671	0.1975
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0479	0.0864	0.0864
Brugia malayi	hypothetical protein	0.0146	0.0203	0.0203
Onchocerca volvulus		0.0201	0.031	0.0712
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0267	0.0443	0.0443
Brugia malayi	Animal haem peroxidase family protein	0.0129	0.017	0.017
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0151	0.0212	0.0212
Schistosoma mansoni	neuronal calcium sensor	0.0201	0.031	0.031
Giardia lamblia	Cysteine protease	0.0267	0.0443	0.1304
Brugia malayi	Animal haem peroxidase family protein	0.0129	0.017	0.017
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0353	0.0613	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Entamoeba histolytica	cysteine proteinase, putative	0.079	0.148	0.8393
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0479	0.0864	0.5834
Onchocerca volvulus	Peroxidase homolog	0.0129	0.017	0.0382
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.079	0.148	0.148
Onchocerca volvulus		0.007	0.0051	0.0105
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0201	0.031	0.176
Entamoeba histolytica	cysteine proteinase 1, putative	0.0479	0.0864	0.4896
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.0443	0.1304
Trypanosoma brucei	cysteine peptidase, putative	0.0382	0.0671	0.1975
Onchocerca volvulus		0.0201	0.031	0.0712
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0254	0.0416	0.0416
Echinococcus multilocularis	cathepsin b	0.5086	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0267	0.0443	0.0443
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0578	0.106	0.3118
Loa Loa (eye worm)	cathepsin B	0.1758	0.3399	0.3399
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0353	0.0613	0.0613
Onchocerca volvulus		0.0267	0.0443	0.1022
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0382	0.0671	0.1975
Schistosoma mansoni	calpain-2 (C02 family)	0.0382	0.0671	0.0671
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0201	0.031	0.031
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0203	0.0316	0.0316
Echinococcus granulosus	calcium uptake protein 1	0.0203	0.0316	0.0316
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.5086	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0267	0.0443	0.0443
Brugia malayi	cathepsin L-like precursor	0.0578	0.106	0.106
Echinococcus multilocularis	calcium uptake protein 1	0.0203	0.0316	0.0316
Entamoeba histolytica	cysteine protease, putative	0.0267	0.0443	0.2512
Echinococcus granulosus	calpain A	0.3721	0.7292	0.7292
Echinococcus granulosus	tumor protein p63	0.0327	0.0562	0.0562
Giardia lamblia	Cathepsin B precursor	0.1758	0.3399	1
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0201	0.031	0.0913
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.1315	0.2521	0.2521
Trypanosoma cruzi	Aph-1 protein, putative	0.0099	0.0109	0.0109
Giardia lamblia	Hypothetical protein	0.0267	0.0443	0.1304
Giardia lamblia	Cathepsin L precursor	0.0267	0.0443	0.1304
Onchocerca volvulus	Cathepsin L homolog	0.079	0.148	0.3449
Entamoeba histolytica	hypothetical protein, conserved	0.0203	0.0316	0.1792
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Plasmodium falciparum	serine repeat antigen 3	0.0267	0.0443	0.2993
Entamoeba histolytica	cysteine proteinase, putative	0.0479	0.0864	0.4896
Giardia lamblia	Cysteine protease	0.0267	0.0443	0.1304
Trypanosoma cruzi	centrin, putative	0.0209	0.0327	0.0327
Loa Loa (eye worm)	hypothetical protein	0.3518	0.6889	0.6889
Schistosoma mansoni	reticulocalbin	0.0201	0.031	0.031
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0012	0.0035
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0267	0.0443	0.0443
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0882	0.1661	0.4887
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0147	0.171
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0201	0.031	0.0913
Trypanosoma brucei	Aph-1 protein, putative	0.0099	0.0109	0.032
Echinococcus granulosus	histone lysine methyltransferase setb	0.0058	0.0028	0.0028
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0003	0.0003
Echinococcus multilocularis	calpain A	0.3721	0.7292	0.7292
Brugia malayi	Papain family cysteine protease containing protein	0.0479	0.0864	0.0864
Entamoeba histolytica	grainin 2	0.0209	0.0327	0.1851
Leishmania major	cathepsin L-like protease	0.0882	0.1661	0.4887
Loa Loa (eye worm)	animal heme peroxidase	0.0129	0.017	0.017
Leishmania major	proteasome beta 5 subunit, putative	0.0151	0.0212	0.0624
Trichomonas vaginalis	myosin light chain 1, putative	0.0201	0.031	0.0913
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0254	0.0416	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0093	0.0098	0.0553
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0267	0.0443	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0203	0.0203
Entamoeba histolytica	cysteine protease, putative	0.0267	0.0443	0.2512
Echinococcus granulosus	calpain	0.1315	0.2521	0.2521
Schistosoma mansoni	calmodulin	0.0201	0.031	0.031
Schistosoma mansoni	calmodulin	0.0201	0.031	0.031
Onchocerca volvulus		0.079	0.148	0.3449
Leishmania major	centrin, putative	0.0201	0.031	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0129	0.017	0.017
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0118	0.0147	0.0668
Toxoplasma gondii	centrin, putative	0.0201	0.031	0.0913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1758	0.3399	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.0443	0.1304
Trypanosoma brucei	calpain-like protein, putative	0.1315	0.2521	0.7419
Onchocerca volvulus	Cathepsin L homolog	0.079	0.148	0.3449
Onchocerca volvulus	Chorion peroxidase homolog	0.0129	0.017	0.0382
Trichomonas vaginalis	calcium binding protein, putative	0.0201	0.031	0.0913
Echinococcus granulosus	EF hand domain containing family member A2	0.0203	0.0316	0.0316
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Brugia malayi	Proteasome A-type and B-type family protein	0.0151	0.0212	0.0212
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0093	0.0098	0.0287
Trypanosoma cruzi	cysteine proteinase, putative	0.0479	0.0864	0.0864
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1758	0.3399	1
Trichomonas vaginalis	set domain proteins, putative	0.0461	0.0827	0.2433
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.1975
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0093	0.0098	0.0098
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0267	0.0443	0.1757
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5086	1	1
Schistosoma mansoni	hypothetical protein	0.0047	0.0006	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0147	0.171
Echinococcus granulosus	neurocalcin	0.0201	0.031	0.031
Schistosoma mansoni	cathepsin F (C01 family)	0.0578	0.106	0.106
Echinococcus multilocularis	calpain	0.1315	0.2521	0.2521
Trypanosoma brucei	calpain, putative	0.0382	0.0671	0.1975
Entamoeba histolytica	cysteine protease, putative	0.0479	0.0864	0.4896
Giardia lamblia	Hypothetical protein	0.0203	0.0316	0.093
Echinococcus granulosus	cathepsin L cysteine proteinase	0.079	0.148	0.148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0118	0.0147	0.0147
Trichomonas vaginalis	calcium binding protein, putative	0.0209	0.0327	0.0961
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0479	0.0864	0.0864
Giardia lamblia	Cathepsin L-like protease	0.0267	0.0443	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0201	0.031	0.031
Echinococcus multilocularis	cathepsin b	0.5086	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0267	0.0443	0.0443
Plasmodium vivax	vivapain-3	0.0479	0.0864	0.3425
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1758	0.3399	0.3399
Leishmania major	calmodulin-like protein	0.0201	0.031	0.0913
Echinococcus granulosus	calbindin 32	0.0203	0.0316	0.0316
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.0371	0.0371
Echinococcus granulosus	calpain A	0.1315	0.2521	0.2521
Trypanosoma cruzi	kinesin, putative	0.0933	0.1763	0.1763
Trypanosoma brucei	Component of motile flagella 41	0.0201	0.031	0.0913
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0267	0.0443	0.1757
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0013	0.0013
Trichomonas vaginalis	calmodulin, putative	0.0209	0.0327	0.0961
Plasmodium falciparum	serine repeat antigen 1	0.0267	0.0443	0.2993
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0093	0.0098	0.0553
Giardia lamblia	Cathepsin B precursor	0.0267	0.0443	0.1304
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1758	0.3399	0.3399
Schistosoma mansoni	hypothetical protein	0.007	0.0051	0.0051
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0267	0.0443	0.0443
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.079	0.148	0.4355
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0382	0.0671	0.0671
Trypanosoma cruzi	cysteine peptidase, putative	0.0212	0.0333	0.0333
Trypanosoma brucei	prolyl endopeptidase	0.0888	0.1674	0.4924
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0443	0.0443
Brugia malayi	Peroxidasin	0.0129	0.017	0.017
Entamoeba histolytica	calpain family cysteine protease, putative	0.0382	0.0671	0.3806
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0093	0.0098	0.0098
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0201	0.031	0.031
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0382	0.0671	0.0671
Brugia malayi	Animal haem peroxidase family protein	0.0129	0.017	0.017
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0201	0.031	0.031
Brugia malayi	calpain 5	0.0382	0.0671	0.0671
Brugia malayi	prolyl oligopeptidase family protein	0.0093	0.0098	0.0098
Trypanosoma cruzi	cysteine peptidase, putative	0.0882	0.1661	0.1661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.0443	0.1304
Trypanosoma cruzi	cysteine peptidase, putative	0.0882	0.1661	0.1661
Brugia malayi	Animal haem peroxidase family protein	0.0129	0.017	0.017
Brugia malayi	cathepsin L precursor	0.0267	0.0443	0.0443
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0012	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0267	0.0443	0.1304
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.079	0.148	0.148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.079	0.148	0.4355

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.005 uM	inhibitory activity of compound against Multidrug resistant HCT116/VM46 cell line treated with Vinblastine	ChEMBL.	15546712
IC50 (functional)	= 0.005 uM	inhibitory activity of compound against Multidrug resistant HCT116/VM46 cell line treated with Vinblastine	ChEMBL.	15546712
IC50 (functional)	= 0.1 uM	inhibitory activity of compound against Multidrug resistance HCT116/VM46 cell line treated with Doxorubucin	ChEMBL.	15546712
IC50 (functional)	= 0.1 uM	inhibitory activity of compound against Multidrug resistance HCT116/VM46 cell line treated with Doxorubucin	ChEMBL.	15546712
IC50 (functional)	= 40 uM	Intrinsic cytotoxic activity of the compound against Multidrug resistant HCT116/VM46 cell line	ChEMBL.	15546712
IC50 (functional)	= 40 uM	Intrinsic cytotoxic activity of the compound against Multidrug resistant HCT116/VM46 cell line	ChEMBL.	15546712
IC50 (functional)	= 45 uM	Intrinsic cytotoxic activity of the compound against wild type HCT116 cell line	ChEMBL.	15546712
IC50 (functional)	= 45 uM	Intrinsic cytotoxic activity of the compound against wild type HCT116 cell line	ChEMBL.	15546712
Reversion (functional)	= 80 %	Multi drug resistance reversal in HCT116/VM46 cell line treated with Vinblastine	ChEMBL.	15546712
Reversion (functional)	= 80 %	Multi drug resistance reversal in HCT116/VM46 cell line treated with Vinblastine	ChEMBL.	15546712
Reversion (functional)	= 100 %	Multi drug resistance reversal in HCT116/VM46 cell line treated with Doxorubucin	ChEMBL.	15546712
Reversion (functional)	= 100 %	Multi drug resistance reversal in HCT116/VM46 cell line treated with Doxorubucin	ChEMBL.	15546712

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	15546712

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 328868