Detailed information for compound 348943

Basic information

Technical information
  • TDR Targets ID: 348943
  • Name: 4-[2-[(3-chlorobenzoyl)amino]-4-(propan-2-ylc arbamoyl)phenyl]-N-ethyl-1,4-diazepane-1-carb oxamide
  • MW: 486.006 | Formula: C25H32ClN5O3
  • H donors: 3 H acceptors: 3 LogP: 3.41 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)N1CCCN(CC1)c1ccc(cc1NC(=O)c1cccc(c1)Cl)C(=O)NC(C)C
  • InChi: 1S/C25H32ClN5O3/c1-4-27-25(34)31-12-6-11-30(13-14-31)22-10-9-19(23(32)28-17(2)3)16-21(22)29-24(33)18-7-5-8-20(26)15-18/h5,7-10,15-17H,4,6,11-14H2,1-3H3,(H,27,34)(H,28,32)(H,29,33)
  • InChiKey: VOLHEDJKVLFUHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[(3-chlorobenzoyl)amino]-4-(isopropylcarbamoyl)phenyl]-N-ethyl-1,4-diazepane-1-carboxamide
  • 4-[2-[[(3-chlorophenyl)-oxomethyl]amino]-4-[(isopropylamino)-oxomethyl]phenyl]-N-ethyl-1,4-diazepane-1-carboxamide
  • 4-[2-[(3-chlorophenyl)carbonylamino]-4-(propan-2-ylcarbamoyl)phenyl]-N-ethyl-1,4-diazepane-1-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-X-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0266 0.048 0.048
Brugia malayi beta-lactamase family protein 0.0038 0.0028 0.0028
Trypanosoma brucei prolyl endopeptidase 0.2226 0.4353 1
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0035 0.0024 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0137 0.0137
Echinococcus granulosus histone deacetylase 6 0.0103 0.0157 0.0157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.0223 0.0511
Trypanosoma brucei caltractin, putative 0.0223 0.0395 0.0908
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.01 0.0152 0.0152
Schistosoma mansoni cathepsin C 0.0389 0.0723 0.0723
Plasmodium vivax unspecified product 0.0437 0.0818 0.2865
Entamoeba histolytica grainin, putative 0.022 0.0388 0.136
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0718 0.0718
Brugia malayi Papain family cysteine protease containing protein 0.0389 0.0723 0.0723
Echinococcus granulosus caspase 2 0.026 0.0467 0.0467
Loa Loa (eye worm) peptidase family M13 containing protein 0.0071 0.0093 0.0093
Onchocerca volvulus 0.2216 0.4334 0.9958
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Brugia malayi MH2 domain containing protein 0.0134 0.0219 0.0219
Trypanosoma cruzi histone deacetylase, putative 0.0103 0.0157 0.0157
Onchocerca volvulus 0.003 0.0014 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Loa Loa (eye worm) hypothetical protein 0.0552 0.1044 0.1044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0028
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Schistosoma mansoni neuronal calcium sensor 0.0216 0.0381 0.0381
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0696 0.133 0.3054
Schistosoma mansoni neuronal calcium sensor 0.0216 0.0381 0.0381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Echinococcus granulosus flap endonuclease 1 0.0026 0.0005 0.0004
Schistosoma mansoni ef hand domain family member A2 0.0216 0.0381 0.0381
Trypanosoma brucei kinesin, putative 0.0939 0.181 0.4157
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 0.0028
Plasmodium falciparum serine repeat antigen 5 0.0389 0.0723 0.2533
Trichomonas vaginalis centrin, putative 0.0216 0.0381 0.1059
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0077 0.0106 0.0243
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0077 0.0106 0.0243
Trypanosoma cruzi calmodulin, putative 0.0216 0.0381 0.038
Plasmodium vivax proteasome subunit beta type-5, putative 0.0162 0.0273 0.0957
Loa Loa (eye worm) aspartic protease BmAsp-1 0.003 0.0014 0.0014
Leishmania major hypothetical protein, conserved 0.0046 0.0045 0.0103
Toxoplasma gondii centrin 0.0216 0.0381 0.0874
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0038 0.0106
Plasmodium vivax plasmepsin IV, putative 0.003 0.0014 0.0049
Giardia lamblia Cathepsin L precursor 0.0389 0.0723 0.2013
Schistosoma mansoni calmodulin 0.0216 0.0381 0.0381
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0826 0.1587 0.1587
Leishmania major hypothetical protein, conserved 0.0216 0.0381 0.0874
Brugia malayi Kringle domain containing protein 0.0046 0.0045 0.0045
Brugia malayi Blistered cuticle protein 3 0.017 0.0289 0.0289
Leishmania major hypothetical protein, conserved 0.022 0.0388 0.0892
Brugia malayi regulator of G-protein signaling egl-10 0.0043 0.0038 0.0038
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Trypanosoma brucei calpain-like protein, putative 0.1326 0.2574 0.5913
Brugia malayi Papain family cysteine protease containing protein 0.1467 0.2854 0.2854
Entamoeba histolytica calmodulin, putative 0.0216 0.0381 0.1333
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0038 0.0106
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.003 0.003
Onchocerca volvulus 0.003 0.0013 0.0029
Schistosoma mansoni reticulocalbin 0.022 0.0388 0.0388
Trichomonas vaginalis calcineurin B subunit, putative 0.022 0.0388 0.1081
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0003
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0952 0.1836 0.1836
Mycobacterium ulcerans putative transglutaminase-like protein 0.03 0.0546 0.2973
Loa Loa (eye worm) proteasome subunit beta type 2 0.005 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0389 0.0723 0.2533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Brugia malayi cathepsin L-like cysteine proteinase 0.0389 0.0723 0.0723
Entamoeba histolytica glycogen phosphorylase, putative 0.0115 0.0182 0.0637
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0144 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0219 0.0219
Leishmania major calmodulin-like protein 0.0216 0.0381 0.0874
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0005 0.0015
Trichomonas vaginalis calmodulin, putative 0.0216 0.0381 0.1059
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0077 0.0106 0.0371
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0914 0.1761 0.1761
Entamoeba histolytica prolyl oligopeptidase family protein 0.0334 0.0613 0.2148
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0162 0.0273 0.0957
Echinococcus granulosus peroxidasin 0.017 0.0289 0.0289
Giardia lamblia Hypothetical protein 0.03 0.0546 0.152
Toxoplasma gondii EFHC1, putative 0.0216 0.0381 0.0874
Toxoplasma gondii aspartyl protease ASP1 0.003 0.0014 0.0032
Echinococcus multilocularis calcium uptake protein 1 0.022 0.0388 0.0388
Toxoplasma gondii cathepsin CPC1 0.0389 0.0723 0.1661
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0162 0.0273 0.074
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0952 0.1836 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0043 0.0038 0.0038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0718 0.0718
Brugia malayi Serine protease Z688.6 precursor 0.0063 0.0078 0.0078
Plasmodium vivax aspartyl protease, putative 0.0109 0.017 0.0595
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0038 0.0038
Loa Loa (eye worm) animal heme peroxidase 0.017 0.0289 0.0289
Toxoplasma gondii hypothetical protein 0.0387 0.0718 0.165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Loa Loa (eye worm) calpain 0.1326 0.2574 0.2574
Schistosoma mansoni centrin-related 0.0216 0.0381 0.0381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Echinococcus granulosus beta-adrenergic receptor kinase 0.0043 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0117 0.0184 0.0184
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0024 0.0023
Entamoeba histolytica glycogenphosphorylase, putative 0.005 0.0053 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0334 0.0613 0.0613
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0063 0.0078 0.0218
Toxoplasma gondii histone deacetylase HDAC1 0.0103 0.0157 0.0361
Trypanosoma cruzi cysteine proteinase, putative 0.0826 0.1587 0.1587
Toxoplasma gondii proteasome subunit beta type 2, putative 0.005 0.0052 0.0119
Trypanosoma brucei Calpain-like protein 1.1 0.0387 0.0718 0.165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0723 0.2013
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.0723 0.2013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0334 0.0613 0.0613
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0024 0.0065
Schistosoma mansoni reticulocalbin 0.0216 0.0381 0.0381
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0718 0.1999
Onchocerca volvulus 0.0389 0.0723 0.1661
Toxoplasma gondii PAN domain-containing protein 0.003 0.0013 0.0029
Trypanosoma cruzi cysteine proteinase, putative 0.0826 0.1587 0.1587
Brugia malayi histone deacetylase 1 (HD1) 0.0092 0.0135 0.0135
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1467 0.2854 1
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0038 0.0038
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0043 0.0038 0.0106
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.0223 0.0222
Trypanosoma brucei calmodulin, putative 0.022 0.0388 0.0892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.103 0.199 0.5539
Brugia malayi Cytochrome P450 family protein 0.0058 0.0069 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.0389 0.0723 0.0723
Brugia malayi Animal haem peroxidase family protein 0.017 0.0289 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.5913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Onchocerca volvulus 0.0038 0.0028 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.0223 0.0222
Loa Loa (eye worm) hypothetical protein 0.0176 0.0302 0.0302
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0001 0.0001
Trypanosoma brucei proteasome beta 6 subunit 0.0077 0.0106 0.0243
Trypanosoma brucei centrin-3 0.0223 0.0395 0.0908
Echinococcus granulosus neuronal calcium sensor 0.0216 0.0381 0.038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.003 0.0103
Brugia malayi Histone deacetylase family protein 0.0103 0.0157 0.0157
Mycobacterium ulcerans zinc metalloprotease 0.0095 0.0143 0.0776
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0254 0.0707
Echinococcus multilocularis regulator of G protein signaling 0.0043 0.0038 0.0038
Schistosoma mansoni cpg binding protein 0.0062 0.0076 0.0076
Trypanosoma brucei calpain-like protein, putative 0.1326 0.2574 0.5913
Trypanosoma brucei metacaspase 0.0086 0.0125 0.0286
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0261 0.0469 0.0469
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.1171 0.2268 0.2268
Onchocerca volvulus Legumain homolog 0.0152 0.0254 0.0583
Echinococcus granulosus tumor protein p63 0.0376 0.0697 0.0697
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0024 0.0023
Schistosoma mansoni axis inhibition protein axin 0.0043 0.0038 0.0038
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3758 0.7381 0.7381
Schistosoma mansoni hemoglobinase (C13 family) 0.0152 0.0254 0.0254
Schistosoma mansoni histone deacetylase hda2 0.0044 0.0041 0.0041
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0048 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0178 0.0307 0.0307
Giardia lamblia Cysteine protease 0.0389 0.0723 0.2013
Brugia malayi proteasome subunit beta type 1 0.0077 0.0106 0.0106
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0389 0.0723 0.2533
Onchocerca volvulus 0.003 0.0013 0.0029
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Echinococcus granulosus proteasome prosome macropain 0.0162 0.0273 0.0273
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Entamoeba histolytica cysteine proteinase, putative 0.1467 0.2854 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0334 0.0613 0.0613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0144 0.0144
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0718 0.0718
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0718 0.1999
Brugia malayi calcium-binding protein 0.0216 0.0381 0.0381
Giardia lamblia Cathepsin B precursor 0.1841 0.3592 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0914 0.1761 0.1761
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0038 0.0038
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0216 0.0381 0.038
Toxoplasma gondii exonuclease III APE 0.0038 0.003 0.0067
Schistosoma mansoni histone deacetylase 1 2 3 0.0044 0.0041 0.0041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5083 1 1
Plasmodium falciparum serine repeat antigen 3 0.0389 0.0723 0.2533
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.005 0.0052 0.0052
Leishmania major kinesin, putative 0.0939 0.181 0.4157
Echinococcus multilocularis histone deacetylase 6 0.0103 0.0157 0.0157
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.003 0.003
Echinococcus multilocularis caspase 0.0228 0.0405 0.0405
Echinococcus multilocularis centrin 2 0.0216 0.0381 0.038
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0216 0.0381 0.1059
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1467 0.2854 0.2854
Giardia lamblia Alanyl dipeptidyl peptidase 0.0334 0.0613 0.1707
Toxoplasma gondii cathepsin B 0.1841 0.3592 0.8253
Echinococcus granulosus acylamino acid releasing enzyme 0.0334 0.0613 0.0613
Trypanosoma cruzi conserved protein 0.0387 0.0718 0.0718
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0035 0.0024 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0723 0.2013
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0003
Onchocerca volvulus Glycogen phosphorylase homolog 0.0115 0.0182 0.0418
Echinococcus multilocularis calpain 0.1326 0.2574 0.2574
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0001 0.0001
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Schistosoma mansoni cathepsin s 0.0437 0.0818 0.0818
Echinococcus multilocularis glycoprotein Antigen 5 0.01 0.0152 0.0152
Brugia malayi calpain 5 0.0939 0.181 0.181
Loa Loa (eye worm) proteasome subunit beta type 1 0.0077 0.0106 0.0106
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1841 0.3592 0.8253
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0223 0.0223
Trichomonas vaginalis peptide N-glycanase, putative 0.03 0.0546 0.152
Schistosoma mansoni histone deacetylase 0.0092 0.0135 0.0135
Trypanosoma brucei cysteine peptidase C (CPC) 0.1841 0.3592 0.8253
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0176 0.0302 0.0302
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0389 0.0723 0.2533
Plasmodium vivax aspartyl protease, putative 0.003 0.0014 0.0049
Loa Loa (eye worm) blistered cuticle protein 3 0.017 0.0289 0.0289
Brugia malayi Cathepsin L-like precursor 0.103 0.199 0.199
Loa Loa (eye worm) aspartyl protease 6 0.003 0.0014 0.0014
Schistosoma mansoni cpg binding protein 0.0058 0.0069 0.0069
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0389 0.0723 0.2533
Plasmodium falciparum calpain 0.0387 0.0718 0.2516
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.005 0.0052 0.0145
Brugia malayi calpain D 0.0387 0.0718 0.0718
Echinococcus multilocularis cysteine protease 0.1467 0.2854 0.2854
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0389 0.0723 0.2013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Trypanosoma brucei histone deacetylase, putative 0.0103 0.0157 0.0361
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0952 0.1836 0.4219
Loa Loa (eye worm) cysteine protease 0.1467 0.2854 0.2854
Echinococcus granulosus glycoprotein Antigen 5 0.01 0.0152 0.0152
Trypanosoma cruzi I/6 autoantigen, putative 0.0216 0.0381 0.038
Trypanosoma cruzi Aph-1 protein, putative 0.0102 0.0155 0.0155
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0718 0.1999
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0389 0.0723 0.2533
Echinococcus multilocularis survival motor neuron protein 1 0.0266 0.048 0.048
Loa Loa (eye worm) histone deacetylase 1 0.0092 0.0135 0.0135
Trichomonas vaginalis set domain proteins, putative 0.0764 0.1464 0.4074
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0043 0.0038 0.0038
Trypanosoma brucei calpain, putative 0.0387 0.0718 0.165
Trypanosoma cruzi cysteine peptidase, putative 0.1572 0.3061 0.3061
Loa Loa (eye worm) hypothetical protein 0.2216 0.4334 0.4334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0144 0.0144
Brugia malayi gamma-secretase subunit aph-1 0.0261 0.0469 0.0469
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.0013 0.0013
Plasmodium vivax histone deacetylase 1, putative 0.0092 0.0135 0.0473
Plasmodium vivax centrin-1, putative 0.0216 0.0381 0.1333
Echinococcus granulosus geminin 0.0178 0.0307 0.0307
Echinococcus granulosus calmodulin 0.0216 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.0389 0.0723 0.0723
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0389 0.0723 0.2533
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0723 0.2013
Plasmodium vivax vivapain-2 0.1467 0.2854 1
Leishmania major C-8 sterol isomerase-like protein 0.0373 0.0691 0.1588
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0028 0.0028
Giardia lamblia Hypothetical protein 0.0389 0.0723 0.2013
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0063 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0043 0.0038 0.0134
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0003
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.0038 0.0038
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0389 0.0723 0.0723
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1326 0.2574 0.2574
Loa Loa (eye worm) hypothetical protein 0.0071 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.103 0.199 0.199
Loa Loa (eye worm) hypothetical protein 0.2603 0.5098 0.5098
Brugia malayi Eukaryotic aspartyl protease family protein 0.003 0.0014 0.0014
Echinococcus granulosus Tolloid protein 1 0.0047 0.0046 0.0046
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0005 0.001
Brugia malayi Pepsin A precursor 0.003 0.0014 0.0014
Loa Loa (eye worm) histone deacetylase 7A 0.0103 0.0157 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 0.0028
Trypanosoma cruzi Aph-1 protein, putative 0.0102 0.0155 0.0155
Trypanosoma cruzi calmodulin, putative 0.0216 0.0381 0.038
Schistosoma mansoni rab 0.0216 0.0381 0.0381
Trypanosoma brucei metacaspase MCA3 0.0086 0.0125 0.0286
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0162 0.0273 0.0273
Plasmodium falciparum plasmepsin II 0.003 0.0014 0.0049
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.1171 0.2268 0.2268
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3758 0.7381 0.738
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0952 0.1836 0.4219
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0001 0.0001
Trypanosoma brucei histone deacetylase 3 0.0103 0.0157 0.0361
Trypanosoma cruzi calmodulin, putative 0.0216 0.0381 0.038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0179 0.0412
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.0038 0.0038
Mycobacterium tuberculosis Conserved protein 0.03 0.0546 0.1478
Schistosoma mansoni neprilysin-2 (M13 family) 0.0048 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0043 0.0038 0.0038
Echinococcus multilocularis programmed cell death protein 0.0223 0.0395 0.0395
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.01 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0718 0.1999
Echinococcus multilocularis histone deacetylase 3 0.0092 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0389 0.0723 0.2533
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Brugia malayi calpain 7 0.1326 0.2574 0.2574
Loa Loa (eye worm) hypothetical protein 0.0097 0.0146 0.0146
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0077 0.0106 0.0371
Loa Loa (eye worm) glycogen phosphorylase 0.0115 0.0182 0.0182
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0162 0.0273 0.0273
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3542 0.6954 0.6954
Giardia lamblia Thymus-specific serine protease precursor 0.0063 0.0078 0.0218
Schistosoma mansoni hypothetical protein 0.0173 0.0297 0.0297
Onchocerca volvulus 0.0063 0.0078 0.018
Trypanosoma cruzi histone deacetylase 1, putative 0.0092 0.0135 0.0135
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Toxoplasma gondii PAN/Apple domain-containing protein 0.003 0.0013 0.0029
Echinococcus granulosus histone deacetylase 6 0.0103 0.0157 0.0157
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0028 0.0152
Schistosoma mansoni calpain-7 (C02 family) 0.1329 0.258 0.258
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0038 0.0038
Trichomonas vaginalis calmodulin, putative 0.0223 0.0395 0.11
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Onchocerca volvulus Peroxidasin homolog 0.017 0.0289 0.0664
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.0125 0.0286
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0254 0.0707
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0152 0.0254 0.0254
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0389 0.0723 0.2533
Schistosoma mansoni ap endonuclease 0.0038 0.003 0.003
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0005 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0831 0.1596 0.1595
Entamoeba histolytica calpain family cysteine protease, putative 0.0387 0.0718 0.2516
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0001 0.0001
Entamoeba histolytica glycogen phosphorylase, putative 0.005 0.0053 0.0184
Onchocerca volvulus 0.0055 0.0063 0.0144
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.003 0.0082
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.005 0.0053 0.0286
Plasmodium falciparum serine repeat antigen 4 0.0389 0.0723 0.2533
Echinococcus granulosus expressed protein 0.0831 0.1596 0.1595
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0389 0.0723 0.2533
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0437 0.0818 0.0818
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0028 0.0152
Giardia lamblia Serine peptidase, putative 0.0063 0.0078 0.0218
Echinococcus granulosus histone deacetylase 7 0.0103 0.0157 0.0157
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.5913
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0038 0.0038
Onchocerca volvulus 0.003 0.0013 0.0029
Brugia malayi Cathepsin L-like precursor 0.1467 0.2854 0.2854
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0001 0.0002
Schistosoma mansoni calmodulin 0.0216 0.0381 0.0381
Loa Loa (eye worm) calpain family protein 1 0.2603 0.5098 0.5098
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1841 0.3592 0.3592
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0389 0.0723 0.0723
Onchocerca volvulus 0.01 0.0152 0.035
Plasmodium vivax hypothetical protein, conserved 0.022 0.0388 0.136
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1182 0.229 0.229
Trypanosoma cruzi I/6 autoantigen, putative 0.0216 0.0381 0.038
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0077 0.0106 0.0106
Toxoplasma gondii microneme protein MIC4 0.003 0.0013 0.0029
Loa Loa (eye worm) TK/ROR protein kinase 0.0046 0.0045 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.0826 0.1587 0.556
Onchocerca volvulus 0.003 0.0013 0.0029
Schistosoma mansoni neuronal calcium sensor 0.0216 0.0381 0.0381
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0028 0.0078
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.01 0.0152 0.0152
Toxoplasma gondii aspartyl protease ASP3 0.0109 0.017 0.039
Onchocerca volvulus 0.017 0.0289 0.0664
Toxoplasma gondii microneme protein MIC17C 0.003 0.0013 0.0029
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0914 0.1761 0.4045
Loa Loa (eye worm) hypothetical protein 0.0071 0.0093 0.0093
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.01 0.0152 0.0152
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.0078
Echinococcus multilocularis histone deacetylase 8 0.0044 0.0041 0.0041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0078 0.0218
Loa Loa (eye worm) RGS-3 protein 0.0043 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0381 0.1059
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.003 0.0103
Trichomonas vaginalis calmodulin, putative 0.0216 0.0381 0.1059
Loa Loa (eye worm) hypothetical protein 0.0043 0.0038 0.0038
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Toxoplasma gondii hypothetical protein 0.003 0.0013 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Leishmania major i/6 autoantigen-like protein 0.0216 0.0381 0.0874
Loa Loa (eye worm) hypothetical protein 0.3542 0.6954 0.6954
Echinococcus granulosus dnaJ subfamily B 0.0831 0.1596 0.1595
Brugia malayi Cytochrome P450 family protein 0.0035 0.0024 0.0024
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Plasmodium vivax histone deacetylase, putative 0.0044 0.0041 0.0144
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0334 0.0613 0.0613
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0723 0.2013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0723 0.2013
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0014
Plasmodium vivax GPI-anchor transamidase, putative 0.0035 0.0024 0.0082
Schistosoma mansoni gamma-secretase subunit aph-1 0.0261 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0043 0.0038 0.0038
Entamoeba histolytica hypothetical protein, conserved 0.0334 0.0613 0.2148
Echinococcus granulosus cathepsin b 0.5083 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.005 0.0052 0.0182
Entamoeba histolytica cysteine proteinase 1, putative 0.0826 0.1587 0.556
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0152 0.0152
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0063 0.0078 0.0078
Entamoeba histolytica cysteine protease, putative 0.0389 0.0723 0.2533
Entamoeba histolytica cysteine proteinase 2 0.0826 0.1587 0.556
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0389 0.0723 0.0723
Mycobacterium tuberculosis Probable peptidase 0.0952 0.1836 0.4972
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0387 0.0718 0.0718
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Echinococcus granulosus Transglutaminase 0.03 0.0546 0.0546
Entamoeba histolytica cysteine proteinase, putative 0.0826 0.1587 0.556
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0389 0.0723 0.2013
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.0125 0.0286
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0952 0.1836 0.1836
Schistosoma mansoni peroxidasin 0.017 0.0289 0.0289
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0146 0.0146
Plasmodium vivax aspartyl proteinase, putative 0.003 0.0014 0.0049
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Leishmania major histone deacetylase, putative 0.0103 0.0157 0.0361
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0389 0.0723 0.2533
Trypanosoma brucei calmodulin, putative 0.0216 0.0381 0.0874
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0001 0.0001
Leishmania major metacaspase, putative 0.0086 0.0125 0.0286
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Trichomonas vaginalis calmodulin-2, putative 0.0216 0.0381 0.1059
Plasmodium vivax histone deacetylase, putative 0.0103 0.0157 0.0551
Toxoplasma gondii PAN domain-containing protein 0.003 0.0013 0.0029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0836 0.1607 0.1607
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.005 0.0053 0.0142
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) hypothetical protein 0.0173 0.0297 0.0297
Leishmania major cathepsin L-like protease 0.1467 0.2854 0.6556
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0334 0.0613 0.1707
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.5083 1 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0028 0.0098
Entamoeba histolytica calcium-binding protein, putative 0.0216 0.0381 0.1333
Echinococcus multilocularis hypothetical protein 0.1326 0.2574 0.2574
Onchocerca volvulus 0.1467 0.2854 0.6556
Brugia malayi Trypsin family protein 0.01 0.0152 0.0152
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0048 0.0049 0.0049
Brugia malayi hypothetical protein 0.0266 0.048 0.048
Leishmania major cathepsin L-like protease 0.1467 0.2854 0.6556
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0254 0.0707
Giardia lamblia Cathepsin L precursor 0.0389 0.0723 0.2013
Toxoplasma gondii preprocathepsin c precursor, putative 0.0389 0.0723 0.1661
Echinococcus granulosus histone deacetylase 0.0103 0.0157 0.0157
Brugia malayi Histone deacetylase 1 0.0092 0.0135 0.0135
Brugia malayi EF hand family protein 0.022 0.0388 0.0388
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Onchocerca volvulus Dual oxidase homolog 0.017 0.0289 0.0664
Schistosoma mansoni histone deacetylase 4 5 0.0103 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.01 0.0152 0.0152
Schistosoma mansoni histone deacetylase 4 5 0.0103 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0389 0.0723 0.0723
Giardia lamblia Cysteine protease 0.0389 0.0723 0.2013
Brugia malayi Peptidase family M13 containing protein 0.0095 0.0143 0.0143
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Entamoeba histolytica cysteine protease, putative 0.1467 0.2854 1
Plasmodium falciparum plasmepsin V 0.003 0.0014 0.0049
Schistosoma mansoni axis inhibition protein axin 0.0043 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.1587 0.3645
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.003 0.0014 0.0014
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0216 0.0381 0.038
Trichomonas vaginalis calmodulin, putative 0.0216 0.0381 0.1059
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Loa Loa (eye worm) hypothetical protein 0.0063 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.0723 0.2013
Schistosoma mansoni glycogen phosphorylase 0.005 0.0053 0.0053
Trichomonas vaginalis histone deacetylase, putative 0.0092 0.0135 0.0375
Trypanosoma brucei Calpain-like protein 2 0.0387 0.0718 0.165
Loa Loa (eye worm) hypothetical protein 0.1467 0.2854 0.2854
Brugia malayi Animal haem peroxidase family protein 0.017 0.0289 0.0289
Plasmodium falciparum serine repeat antigen 6 0.0389 0.0723 0.2533
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.003 0.0067
Trichomonas vaginalis calpain, putative 0.0387 0.0718 0.1999
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0125 0.0347
Brugia malayi Animal haem peroxidase family protein 0.017 0.0289 0.0289
Brugia malayi beta-lactamase family protein 0.0038 0.0028 0.0028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) hypothetical protein 0.0168 0.0286 0.0286
Brugia malayi carbohydrate phosphorylase 0.0115 0.0182 0.0182
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0049 0.0049
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.0013 0.0013
Toxoplasma gondii peptidase c13 family protein 0.0035 0.0024 0.0054
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0363 0.0671 0.0671
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.003 0.0067
Trypanosoma cruzi centrin, putative 0.0223 0.0395 0.0395
Trypanosoma cruzi oligopeptidase b 0.0952 0.1836 0.1836
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0038 0.0106
Echinococcus multilocularis enteropeptidase 0.01 0.0152 0.0152
Giardia lamblia Cathepsin L precursor 0.0389 0.0723 0.2013
Brugia malayi Cell death protein 3 precursor 0.026 0.0467 0.0467
Loa Loa (eye worm) calpain 5 0.0939 0.181 0.181
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1467 0.2854 1
Trichomonas vaginalis histone deacetylase, putative 0.0092 0.0135 0.0375
Entamoeba histolytica cysteine proteinase, putative 0.103 0.199 0.6973
Schistosoma mansoni survival motor neuron protein 0.0054 0.0061 0.0061
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.0041 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0038 0.0038
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Mycobacterium tuberculosis Conserved protein 0.0038 0.0028 0.0076
Trichomonas vaginalis calcium binding protein, putative 0.0216 0.0381 0.1059
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.005 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.5083 1 1
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0254 0.0707
Loa Loa (eye worm) histone deacetylase 11 0.0044 0.0041 0.0041
Echinococcus multilocularis histone deacetylase 1 0.0092 0.0135 0.0135
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Brugia malayi Papain family cysteine protease containing protein 0.0826 0.1587 0.1587
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.0013 0.0013
Echinococcus granulosus cathepsin L 0.0826 0.1587 0.1587
Entamoeba histolytica calpain large subunit domain III containing protein 0.0939 0.181 0.6341
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0078 0.0218
Echinococcus granulosus prolyl endopeptidase 0.2226 0.4353 0.4353
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0216 0.0381 0.0874
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Plasmodium falciparum GPI-anchor transamidase, putative 0.0035 0.0024 0.0082
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0152 0.0152
Brugia malayi prolyl oligopeptidase family protein 0.0334 0.0613 0.0613
Echinococcus multilocularis histone deacetylase 0.0103 0.0157 0.0157
Plasmodium falciparum metacaspase-like protein 0.0086 0.0125 0.0437
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0077 0.0106 0.0106
Plasmodium falciparum serine repeat antigen 8 0.0389 0.0723 0.2533
Echinococcus granulosus GPI anchor transamidase 0.0035 0.0024 0.0023
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1326 0.2574 0.2574
Plasmodium falciparum histone deacetylase 1 0.0092 0.0135 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0125 0.0347
Echinococcus multilocularis GPI anchor transamidase 0.0035 0.0024 0.0023
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0095 0.0143 0.0143
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0001 0.0001
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0389 0.0723 0.0723
Trypanosoma cruzi cysteine peptidase, putative 0.1572 0.3061 0.3061
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.005 0.0052 0.0052
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.003 0.0014 0.0014
Trichomonas vaginalis glycogen phosphorylase, putative 0.0115 0.0182 0.0506
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Echinococcus granulosus Mastin 0.01 0.0152 0.0152
Plasmodium falciparum flap endonuclease 1 0.0026 0.0005 0.0015
Mycobacterium tuberculosis Hypothetical protein 0.03 0.0546 0.1478
Toxoplasma gondii aspartyl protease 0.003 0.0014 0.0032
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0216 0.0381 0.038
Mycobacterium ulcerans hypothetical protein 0.01 0.0152 0.0829
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0216 0.0381 0.1333
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0125 0.0347
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.003 0.0029
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Echinococcus granulosus histone deacetylase 1 0.0092 0.0135 0.0135
Entamoeba histolytica cysteine protease, putative 0.0389 0.0723 0.2533
Giardia lamblia Hypothetical protein 0.0389 0.0723 0.2013
Trichomonas vaginalis calmodulin, putative 0.022 0.0388 0.1081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0223 0.1211
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0387 0.0718 0.165
Brugia malayi calpain family protein 1 0.3542 0.6954 0.6954
Echinococcus multilocularis tissue type plasminogen activator 0.0046 0.0045 0.0045
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0826 0.1587 0.1587
Onchocerca volvulus 0.1467 0.2854 0.6556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0723 0.0723
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0043 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0063 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0826 0.1587 0.4417
Echinococcus multilocularis Glycosyl transferase, family 35 0.0115 0.0182 0.0182
Plasmodium vivax aspartyl proteinase, putative 0.003 0.0014 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0063 0.0063
Leishmania major hypothetical protein, unknown function 0.0387 0.0718 0.165
Trichomonas vaginalis calcium binding proteins, putative 0.0216 0.0381 0.1059
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Echinococcus granulosus histone deacetylase 6 0.0109 0.017 0.017
Brugia malayi Cathepsin L-like precursor 0.1467 0.2854 0.2854
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0028 0.0076
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Brugia malayi cathepsin Z-like cysteine proteinase 0.0389 0.0723 0.0723
Trypanosoma brucei histone deacetylase 1 0.0092 0.0135 0.031
Trypanosoma cruzi cruzipain precursor, putative 0.0437 0.0818 0.0818
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0389 0.0723 0.2013
Loa Loa (eye worm) hypothetical protein 0.0063 0.0078 0.0078
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0373 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0005 0.0005
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.5913
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0003
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0389 0.0723 0.2533
Toxoplasma gondii microneme protein MIC17B 0.003 0.0013 0.0029
Echinococcus multilocularis cathepsin L cysteine protease 0.1467 0.2854 0.2854
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Brugia malayi Peroxidasin 0.017 0.0289 0.0289
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0063 0.0078 0.0274
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.2226 0.4353 0.4353
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0125 0.0347
Loa Loa (eye worm) hypothetical protein 0.0086 0.0125 0.0125
Trichomonas vaginalis histone deacetylase, putative 0.0092 0.0135 0.0375
Loa Loa (eye worm) hypothetical protein 0.0191 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0028
Echinococcus multilocularis transmembrane protease serine 3 0.01 0.0152 0.0152
Trichomonas vaginalis calcium binding protein, putative 0.0216 0.0381 0.1059
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.2226 0.4353 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0043 0.0038 0.0038
Plasmodium vivax vivapain-3 0.0826 0.1587 0.556
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0216 0.0381 0.0381
Loa Loa (eye worm) animal heme peroxidase 0.017 0.0289 0.0289
Echinococcus multilocularis calmodulin 0.0216 0.0381 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0038 0.0106
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0001 0.0001
Giardia lamblia GPI-anchor transamidase, putative 0.0035 0.0024 0.0065
Echinococcus granulosus cpg binding protein 0.0062 0.0076 0.0076
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3758 0.7381 0.7381
Echinococcus granulosus programmed cell death protein 0.0223 0.0395 0.0395
Trypanosoma brucei calpain, putative 0.0387 0.0718 0.165
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0718 0.0718
Loa Loa (eye worm) peptidase family M13 containing protein 0.0071 0.0093 0.0093
Brugia malayi Cytochrome P450 family protein 0.0035 0.0024 0.0024
Echinococcus granulosus cathepsin l1 0.103 0.199 0.199
Schistosoma mansoni peroxidasin 0.017 0.0289 0.0289
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.0125 0.0286
Schistosoma mansoni ap endonuclease 0.0038 0.003 0.003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.003 0.0014 0.0032
Leishmania major cathepsin L-like protease 0.1467 0.2854 0.6556
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Brugia malayi calpain 5 0.0387 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.103 0.199 0.199
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0035 0.0024 0.0054
Toxoplasma gondii calmodulin CAM1 0.022 0.0388 0.0892
Entamoeba histolytica hypothetical protein 0.0043 0.0038 0.0134
Onchocerca volvulus 0.003 0.0013 0.0029
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1182 0.229 0.2289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Leishmania major centrin, putative,caltractin, putative 0.0216 0.0381 0.0874
Echinococcus granulosus cathepsin L cysteine protease 0.0826 0.1587 0.1587
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0005 0.001
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0389 0.0723 0.2533
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.0143 0.0143
Plasmodium falciparum cysteine proteinase falcipain 1 0.0826 0.1587 0.556
Leishmania major cathepsin L-like protease 0.1572 0.3061 0.7032
Trichomonas vaginalis calmodulin, putative 0.0216 0.0381 0.1059
Echinococcus granulosus endothelin converting enzyme 1 0.0095 0.0143 0.0142
Trichomonas vaginalis histone deacetylase, putative 0.0092 0.0135 0.0375
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Schistosoma mansoni caspase-7 (C14 family) 0.0228 0.0405 0.0405
Loa Loa (eye worm) beta-lactamase 0.0038 0.0028 0.0028
Entamoeba histolytica glycogen phosphorylase, putative 0.005 0.0053 0.0184
Brugia malayi proteasome subunit beta type 2 0.005 0.0052 0.0052
Schistosoma mansoni cathepsin S (C01 family) 0.0389 0.0723 0.0723
Echinococcus granulosus Regulator of G protein signaling 20 0.0043 0.0038 0.0038
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0952 0.1836 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Loa Loa (eye worm) hypothetical protein 0.01 0.0152 0.0152
Echinococcus granulosus microtubule associated protein 2 0.1536 0.2989 0.2989
Plasmodium falciparum serine repeat antigen 1 0.0389 0.0723 0.2533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Onchocerca volvulus 0.0168 0.0286 0.0657
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.0078
Plasmodium vivax vivapain-1 0.0826 0.1587 0.556
Echinococcus multilocularis programmed cell death protein 0.0223 0.0395 0.0395
Schistosoma mansoni hemoglobinase (C13 family) 0.0152 0.0254 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Giardia lamblia Cathepsin B precursor 0.1841 0.3592 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0028 0.0064
Schistosoma mansoni glycogen phosphorylase 0.0115 0.0182 0.0182
Schistosoma mansoni centrin 0.0216 0.0381 0.0381
Toxoplasma gondii ABC1 family protein 0.0038 0.0028 0.0064
Loa Loa (eye worm) hypothetical protein 0.0176 0.0302 0.0302
Brugia malayi Probable ATP-dependent helicase DHX35 0.0031 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0176 0.0302 0.0302
Brugia malayi Pre-SET motif family protein 0.0671 0.1281 0.1281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0005 0.0004
Plasmodium vivax metacaspase 1, putative 0.0086 0.0125 0.0437
Onchocerca volvulus Chorion peroxidase homolog 0.017 0.0289 0.0664
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.5913
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0077 0.0106 0.0106
Leishmania major calpain family cysteine protease-like protein 0.0387 0.0718 0.165
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.0826 0.1587 0.1587
Echinococcus multilocularis expressed protein 0.0831 0.1596 0.1595
Giardia lamblia Cathepsin L-like protease 0.0389 0.0723 0.2013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Brugia malayi aspartic protease BmAsp-1, identical 0.003 0.0014 0.0014
Giardia lamblia Cathepsin B precursor 0.0389 0.0723 0.2013
Onchocerca volvulus 0.0176 0.0302 0.0694
Trypanosoma cruzi kinesin, putative 0.0939 0.181 0.1809
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0718 0.0718
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0718 0.1999
Entamoeba histolytica cysteine protease, putative 0.0389 0.0723 0.2533
Echinococcus multilocularis endothelin converting enzyme 1 0.0095 0.0143 0.0142
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0228 0.0405 0.0405
Trypanosoma brucei histone deacetylase 2 0.0044 0.0041 0.0094
Brugia malayi Cathepsin L-like precursor 0.0437 0.0818 0.0818
Echinococcus granulosus cathepsin l1 0.1467 0.2854 0.2854
Echinococcus multilocularis caspase 8 0.0086 0.0125 0.0125
Mycobacterium ulcerans lipase LipD 0.0038 0.0028 0.0152
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0024 0.0054
Plasmodium falciparum proteasome subunit beta type-2, putative 0.005 0.0052 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0334 0.0613 0.0613
Plasmodium falciparum cysteine proteinase falcipain 3 0.1467 0.2854 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0135 0.0135
Onchocerca volvulus 0.0097 0.0146 0.0336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0028 0.0028
Brugia malayi PXA domain containing protein 0.0043 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Toxoplasma gondii histone deacetylase HDAC3 0.0092 0.0135 0.031
Echinococcus granulosus proteasome prosome macropain subunit beta 0.005 0.0052 0.0052
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Trypanosoma brucei Calpain-like protein 1.2 0.0387 0.0718 0.165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0162 0.0273 0.0273
Leishmania major protein kinase, putative 0.0216 0.0381 0.0874
Trichomonas vaginalis hypothetical protein 0.0387 0.0718 0.1999
Loa Loa (eye worm) hypothetical protein 0.0389 0.0723 0.0723
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0077 0.0106 0.0106
Toxoplasma gondii PAN domain-containing protein 0.003 0.0013 0.0029
Echinococcus multilocularis EF hand domain containing family member A2 0.022 0.0388 0.0388
Plasmodium vivax histone deacetylase 2, putative 0.0103 0.0157 0.0551
Plasmodium falciparum serine repeat antigen 7 0.0389 0.0723 0.2533
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0001 0.0002
Plasmodium vivax plasmepsin V, putative 0.003 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.007
Trypanosoma brucei Aph-1 protein, putative 0.0102 0.0155 0.0355
Schistosoma mansoni calpain (C02 family) 0.1326 0.2574 0.2574
Loa Loa (eye worm) hypothetical protein 0.0437 0.0818 0.0818
Echinococcus multilocularis calumenin 0.022 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.3155 0.619 0.619
Brugia malayi prolyl oligopeptidase family protein 0.0334 0.0613 0.0613
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0914 0.1761 0.1761
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0086 0.0125 0.0125
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0063 0.0078 0.0274
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Echinococcus multilocularis histone deacetylase 7 0.0103 0.0157 0.0157
Leishmania major cathepsin L-like protease 0.1572 0.3061 0.7032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.003 0.0029
Onchocerca volvulus 0.1467 0.2854 0.6556
Loa Loa (eye worm) hypothetical protein 0.0437 0.0818 0.0818
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.005 0.0052 0.0145
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1841 0.3592 0.3592
Loa Loa (eye worm) calpain D 0.0387 0.0718 0.0718
Echinococcus granulosus cathepsin b 0.5083 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Echinococcus multilocularis neurocalcin 0.0216 0.0381 0.038
Echinococcus granulosus tissue type plasminogen activator 0.0046 0.0045 0.0045
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Plasmodium falciparum plasmepsin III 0.003 0.0014 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.1467 0.2854 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0162 0.0273 0.0273
Giardia lamblia Cathepsin B precursor 0.0389 0.0723 0.2013
Trichomonas vaginalis conserved hypothetical protein 0.0387 0.0718 0.1999
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0389 0.0723 0.0723
Trichomonas vaginalis glycogen phosphorylase, putative 0.0115 0.0182 0.0506
Brugia malayi cathepsin F-like cysteine proteinase 0.0437 0.0818 0.0818
Trypanosoma cruzi major cysteine proteinase, putative 0.0494 0.093 0.093
Trypanosoma cruzi cysteine peptidase, putative 0.0437 0.0818 0.0818
Brugia malayi EF hand family protein 0.0216 0.0381 0.0381
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0028 0.0076
Loa Loa (eye worm) hypothetical protein 0.0043 0.0038 0.0038
Brugia malayi Peptidase C13 family protein 0.0152 0.0254 0.0254
Schistosoma mansoni hypothetical protein 0.0831 0.1596 0.1596
Onchocerca volvulus 0.017 0.0289 0.0664
Schistosoma mansoni caspase-3 (C14 family) 0.0228 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.026 0.0467 0.0467
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0025 0.0003 0.0003
Leishmania major centrin, putative 0.0216 0.0381 0.0874
Schistosoma mansoni inhibitor of apoptosis protein 0.0176 0.0302 0.0302
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Toxoplasma gondii calcium-dependent protein kinase 0.022 0.0388 0.0892
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Echinococcus multilocularis Transglutaminase 0.03 0.0546 0.0546
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0718 0.0718
Brugia malayi Trypsin family protein 0.01 0.0152 0.0152
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0334 0.0613 0.0613
Schistosoma mansoni glycogen phosphorylase 0.0115 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0389 0.0723 0.0723
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0063 0.0078 0.018
Echinococcus multilocularis calpain 7 (C02 family) 0.1326 0.2574 0.2574
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Echinococcus granulosus glycogen phosphorylase 0.0115 0.0182 0.0182
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0162 0.0273 0.0628
Toxoplasma gondii PAN domain-containing protein 0.003 0.0013 0.0029
Echinococcus multilocularis neuronal calcium sensor 0.0216 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0334 0.0613 0.2148
Onchocerca volvulus 0.01 0.0152 0.035
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0389 0.0723 0.0723
Loa Loa (eye worm) animal heme peroxidase 0.017 0.0289 0.0289
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0387 0.0718 0.165
Mycobacterium leprae probable zinc metalloprotease 0.0095 0.0143 0.0776
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Onchocerca volvulus 0.003 0.0013 0.0029
Brugia malayi Protein kinase domain containing protein 0.0046 0.0045 0.0045
Echinococcus granulosus caspase 8 0.0086 0.0125 0.0125
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.003 0.0014 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Mycobacterium tuberculosis Conserved hypothetical protein 0.03 0.0546 0.1478
Mycobacterium leprae Conserved hypothetical protein 0.03 0.0546 0.2973
Plasmodium vivax proteasome subunit beta type-1, putative 0.0077 0.0106 0.0371
Schistosoma mansoni calpain-7 (C02 family) 0.1329 0.258 0.258
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3758 0.7381 0.738
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0718 0.165
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0216 0.0381 0.038
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0389 0.0723 0.2533
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0028
Plasmodium falciparum histone deacetylase, putative 0.0103 0.0157 0.0551
Leishmania major cathepsin L-like protease 0.1467 0.2854 0.6556
Loa Loa (eye worm) EF hand family protein 0.0216 0.0381 0.0381
Trypanosoma cruzi metacaspase, putative 0.0086 0.0125 0.0125
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0228 0.0405 0.0405
Echinococcus granulosus EF hand domain containing family member A2 0.022 0.0388 0.0388
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0028 0.0076
Echinococcus granulosus apoptotic protease activating factor 1 0.0173 0.0297 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0146 0.0146
Trypanosoma cruzi metacaspase, putative 0.0086 0.0125 0.0125
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0206 0.0206
Loa Loa (eye worm) histone deacetylase 3 0.0092 0.0135 0.0135
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.2226 0.4353 0.4353
Plasmodium falciparum plasmepsin IV 0.003 0.0014 0.0049
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0952 0.1836 0.4972
Brugia malayi Pre-SET motif family protein 0.0097 0.0146 0.0146
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0043 0.0038 0.0038
Loa Loa (eye worm) prolyl oligopeptidase 0.0334 0.0613 0.0613
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0914 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0437 0.0818 0.0818
Giardia lamblia Cysteine protease 0.0389 0.0723 0.2013
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0077 0.0106 0.0106
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.2574
Brugia malayi Proteasome A-type and B-type family protein 0.0162 0.0273 0.0273
Echinococcus granulosus calbindin 32 0.022 0.0388 0.0388
Entamoeba histolytica prolyl oligopeptidase family protein 0.0334 0.0613 0.2148
Onchocerca volvulus 0.1467 0.2854 0.6556
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0038 0.0038
Echinococcus granulosus cysteine protease 0.0826 0.1587 0.1587
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0028 0.0152
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.0718
Echinococcus multilocularis glycogen phosphorylase 0.0115 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1467 0.2854 0.7944
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0723 0.2013
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.003 1
Trypanosoma cruzi centrin-3 0.0223 0.0395 0.0395
Loa Loa (eye worm) peptidase C13 family protein 0.0152 0.0254 0.0254
Schistosoma mansoni calpain-2 (C02 family) 0.0387 0.0718 0.0718
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0389 0.0723 0.0723
Echinococcus granulosus histone deacetylase 3 0.0092 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.0613 0.1707
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1326 0.2574 0.5913
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0028 0.0076
Brugia malayi Papain family cysteine protease containing protein 0.0389 0.0723 0.0723
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0001 0.0001
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0389 0.0723 0.0723
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Trypanosoma cruzi cysteine protease, putative 0.0826 0.1587 0.1587
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0038 0.0038
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0723 0.2013
Echinococcus multilocularis calpain 5 0.1326 0.2574 0.2574
Giardia lamblia Proteasome subunit beta type 2 0.005 0.0052 0.0145
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0389 0.0723 0.2013
Plasmodium vivax serine-repeat antigen (SERA) 0.0389 0.0723 0.2533
Plasmodium vivax unspecified product 0.0826 0.1587 0.556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0144 0.0144
Brugia malayi Trypsin family protein 0.01 0.0152 0.0152
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0001 0.0001
Echinococcus multilocularis calmodulin 0.0216 0.0381 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0125 0.0347
Entamoeba histolytica cysteine proteinase, putative 0.0826 0.1587 0.556
Giardia lamblia Cysteine protease 0.0389 0.0723 0.2013
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0389 0.0723 0.2533
Brugia malayi Trypsin family protein 0.01 0.0152 0.0152
Trypanosoma brucei calpain-like protein, putative 0.1326 0.2574 0.5913
Trypanosoma cruzi cysteine peptidase, putative 0.1572 0.3061 0.3061
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Brugia malayi histone deacetylase 3 (HD3) 0.0092 0.0135 0.0135
Trypanosoma brucei oligopeptidase b 0.0952 0.1836 0.4219
Trypanosoma cruzi caltractin, putative 0.0216 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.01 0.0152 0.0152
Schistosoma mansoni mitochondrial solute carrier 0.0216 0.0381 0.0381
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Trypanosoma cruzi metacaspase 5, putative 0.0086 0.0125 0.0125
Loa Loa (eye worm) DEAH box polypeptide 35 0.0031 0.0016 0.0016
Mycobacterium tuberculosis Long conserved protein 0.03 0.0546 0.1478
Loa Loa (eye worm) hypothetical protein 0.0373 0.0691 0.0691
Trypanosoma brucei centrin, putative 0.0216 0.0381 0.0874
Giardia lamblia Cathepsin B precursor 0.0389 0.0723 0.2013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Echinococcus multilocularis inhibitor of apoptosis protein 0.0176 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1467 0.2854 0.7944
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.2574
Plasmodium vivax proteasome subunit beta type-2, putative 0.005 0.0052 0.0182
Trypanosoma cruzi cysteine peptidase, putative 0.1467 0.2854 0.2854
Loa Loa (eye worm) animal heme peroxidase 0.017 0.0289 0.0289
Loa Loa (eye worm) calpain family protein 1 0.3542 0.6954 0.6954
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0216 0.0381 0.038
Echinococcus granulosus caspase 0.0228 0.0405 0.0405
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0028 0.0076
Echinococcus multilocularis cathepsin L 0.0826 0.1587 0.1587
Mycobacterium ulcerans hypothetical protein 0.0038 0.0028 0.0152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0381 0.1059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0045 0.0045
Leishmania major hypothetical protein, conserved 0.0038 0.0028 0.0064
Echinococcus multilocularis cathepsin L 0.0389 0.0723 0.0723
Mycobacterium tuberculosis Conserved protein 0.0038 0.0028 0.0076
Toxoplasma gondii histone deacetylase HDAC5 0.0044 0.0042 0.0096
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0024 0.0065
Leishmania major hypothetical protein, conserved 0.0387 0.0718 0.165
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Entamoeba histolytica calcium binding family protein 0.0216 0.0381 0.1333
Brugia malayi Cathepsin L-like precursor 0.1467 0.2854 0.2854
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.005 0.0052 0.0052
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.0041 0.0041
Mycobacterium ulcerans proteasome PrcB 0.0162 0.0273 0.1488
Plasmodium falciparum centrin-1 0.0216 0.0381 0.1333
Schistosoma mansoni caspase-7 (C14 family) 0.026 0.0467 0.0467
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.016 0.016
Onchocerca volvulus Peroxidase homolog 0.017 0.0289 0.0664
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0028 0.0078
Trichomonas vaginalis calcium binding protein, putative 0.0216 0.0381 0.1059
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Onchocerca volvulus 0.003 0.0014 0.0032
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0005 0.0012
Brugia malayi hypothetical protein 0.017 0.0289 0.0289
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0043 0.0038 0.0038
Onchocerca volvulus Cathepsin L homolog 0.0389 0.0723 0.1661
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0223 0.0223
Giardia lamblia Encystation-specific protease 0.0389 0.0723 0.2013
Brugia malayi Flap endonuclease-1 0.0026 0.0005 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.003 0.0082
Trypanosoma cruzi 20S proteasome subunit 0.005 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.01 0.0152 0.0152
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0063 0.0078 0.0078
Trypanosoma brucei protein I/6 0.0216 0.0381 0.0874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0146 0.0146
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0219 0.0219
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Trypanosoma brucei metacaspase 5, putative 0.0086 0.0125 0.0286
Onchocerca volvulus 0.1467 0.2854 0.6556
Schistosoma mansoni cathepsin D (A01 family) 0.0122 0.0196 0.0196
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.2574
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Echinococcus granulosus axis inhibition protein axin 0.0043 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1326 0.2574 0.2574
Plasmodium falciparum histone deacetylase 2 0.0103 0.0157 0.0551
Echinococcus multilocularis Tolloid protein 1 0.0047 0.0046 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.0428 0.1158
Schistosoma mansoni neprilysin 0.0025 0.0003 0.0003
Loa Loa (eye worm) ctsf protein 0.1467 0.2854 0.2854
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0005 0.0012
Trypanosoma cruzi metacaspase, putative 0.0086 0.0125 0.0125
Mycobacterium tuberculosis Conserved hypothetical protein 0.03 0.0546 0.1478
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0104 0.016 0.016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.003 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Onchocerca volvulus 0.01 0.0152 0.035
Leishmania major histone deacetylase, putative 0.0103 0.0157 0.0361
Toxoplasma gondii PAN domain-containing protein 0.003 0.0013 0.0029
Echinococcus multilocularis apoptotic protease activating factor 1 0.0173 0.0297 0.0296
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1326 0.2574 0.2574
Leishmania major cathepsin L-like protease 0.1467 0.2854 0.6556
Loa Loa (eye worm) hypothetical protein 0.0266 0.048 0.048
Echinococcus multilocularis geminin 0.0178 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.01 0.0152 0.0152
Brugia malayi cathepsin Z-like cysteine proteinase 0.0389 0.0723 0.0723
Echinococcus granulosus inhibitor of apoptosis protein 0.0176 0.0302 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0389 0.0723 0.2013
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0389 0.0723 0.2533
Brugia malayi cathepsin F-like cysteine proteinase 0.0389 0.0723 0.0723
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0125 0.0437
Giardia lamblia Cathepsin L precursor 0.0389 0.0723 0.2013
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0001 0.0001
Plasmodium falciparum peptidase, putative 0.0334 0.0613 0.2148
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0914 0.1761 0.4045
Loa Loa (eye worm) hypothetical protein 0.0095 0.0143 0.0143
Loa Loa (eye worm) programmed cell death protein 6 0.022 0.0388 0.0388
Echinococcus multilocularis Mastin 0.01 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.103 0.199 0.199
Toxoplasma gondii microneme protein, putative 0.003 0.0013 0.0029
Plasmodium falciparum metacaspase 1 0.0086 0.0125 0.0437
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.0273 0.076
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Giardia lamblia Glycogen phosphorylase 0.0115 0.0182 0.0506
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0063 0.0078 0.0218
Leishmania major calmodulin, putative 0.0216 0.0381 0.0874
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0043 0.0038 0.0038
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Leishmania major centrin, putative 0.0216 0.0381 0.0874
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5083 1 1
Onchocerca volvulus 0.0058 0.0069 0.0159
Giardia lamblia Cathepsin L precursor 0.0389 0.0723 0.2013
Toxoplasma gondii kringle domain-containing protein 0.0046 0.0045 0.0103
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0003
Brugia malayi fibroinase precursor 0.0389 0.0723 0.0723
Brugia malayi Serine carboxypeptidase S28 family protein 0.0063 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Echinococcus granulosus caspase 3 0.0142 0.0234 0.0234
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0047 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0723 0.0723
Onchocerca volvulus 0.0173 0.0297 0.0681
Leishmania major cytochrome p450-like protein 0.0035 0.0024 0.0054
Loa Loa (eye worm) hypothetical protein 0.0063 0.0078 0.0078
Leishmania major programmed cell death 6 protein-like protein 0.0216 0.0381 0.0874
Trypanosoma brucei proteasome subunit beta type-2, putative 0.005 0.0052 0.0119
Trichomonas vaginalis centrin, putative 0.0216 0.0381 0.1059
Echinococcus granulosus EF hand domain containing family member A2 0.0216 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.103 0.199 0.199
Echinococcus granulosus Glycosyl transferase family 35 0.0115 0.0182 0.0182
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0152 0.0152
Toxoplasma gondii cathepsin CPC2 0.0389 0.0723 0.1661
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0144 0.0144
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0038 0.0038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0146 0.0146
Toxoplasma gondii proteasome subunit beta type, putative 0.0162 0.0273 0.0628
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0334 0.0613 0.1408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1467 0.2854 0.2854
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.0078
Mycobacterium leprae Probable lipase LipE 0.0038 0.0028 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.103 0.199 0.5539
Schistosoma mansoni hypothetical protein 0.0178 0.0307 0.0307
Onchocerca volvulus 0.022 0.0388 0.0892
Entamoeba histolytica cysteine protease, putative 0.0826 0.1587 0.556
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.003 0.016
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0005 0.001
Loa Loa (eye worm) cathepsin B 0.1841 0.3592 0.3592
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0038 0.0038
Echinococcus granulosus glycogen phosphorylase 0.0115 0.0182 0.0182
Entamoeba histolytica prolyl oligopeptidase family protein 0.0334 0.0613 0.2148
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1467 0.2854 0.2854
Entamoeba histolytica GPI-anchor transamidase, putative 0.0035 0.0024 0.0082
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0028 0.0028
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0914 0.1761 0.4045
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Leishmania major cysteine peptidase A (CPA) 0.1467 0.2854 0.6556
Onchocerca volvulus 0.0038 0.0028 0.0064
Brugia malayi Histone deacetylase family protein 0.0103 0.0157 0.0157
Brugia malayi Animal haem peroxidase family protein 0.017 0.0289 0.0289
Brugia malayi cathepsin L-like precursor 0.103 0.199 0.199
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Echinococcus granulosus cathepsin L cysteine proteinase 0.1467 0.2854 0.2854
Echinococcus multilocularis cpg binding protein 0.0062 0.0076 0.0076
Schistosoma mansoni microtubule-associated protein tau 0.1536 0.2989 0.2989
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0437 0.0818 0.0818
Echinococcus granulosus axis inhibition protein axin 0.0043 0.0038 0.0038
Echinococcus multilocularis calbindin 32 0.022 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0106 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1467 0.2854 0.7944
Trypanosoma brucei antigen, putative 0.1326 0.2574 0.5913
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0146 0.0146
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0001 0.0002
Giardia lamblia Cathepsin L-like protease 0.0389 0.0723 0.2013
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.0038 0.0038
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.01 0.0152 0.0152
Trichomonas vaginalis calcium binding protein, putative 0.0223 0.0395 0.11
Loa Loa (eye worm) aspartic protease BmAsp-2 0.003 0.0014 0.0014
Brugia malayi GPI-anchor transamidase 0.0035 0.0024 0.0024
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1326 0.2574 0.2574
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0001 0.0001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.0038 0.0038
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0176 0.0302 0.0302
Brugia malayi aspartic protease BmAsp-2, identical 0.003 0.0014 0.0014
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0063 0.0078 0.0274
Echinococcus multilocularis histone deacetylase 6 0.0109 0.017 0.017
Loa Loa (eye worm) calmodulin-like protein 0.0216 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0223 0.1211
Giardia lamblia Cathepsin B precursor 0.0389 0.0723 0.2013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Trichomonas vaginalis esterase, putative 0.0038 0.0028 0.0078
Loa Loa (eye worm) hypothetical protein 0.0389 0.0723 0.0723
Onchocerca volvulus 0.03 0.0546 0.1254
Onchocerca volvulus 0.003 0.0013 0.0029
Brugia malayi Cathepsin L-like precursor 0.1467 0.2854 0.2854
Plasmodium falciparum plasmepsin VII 0.003 0.0014 0.0049
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0914 0.1761 0.1761
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0671 0.1281 0.1281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0826 0.1587 0.4417
Loa Loa (eye worm) hypothetical protein 0.0055 0.0063 0.0063
Entamoeba histolytica cysteine protease, putative 0.0389 0.0723 0.2533
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0723 0.0723
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0216 0.0381 0.038
Schistosoma mansoni hypothetical protein 0.01 0.0152 0.0152
Trypanosoma cruzi histone deacetylase, putative 0.0103 0.0157 0.0157
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0043 0.0038 0.0038
Toxoplasma gondii hypothetical protein 0.0334 0.0613 0.1408
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Echinococcus multilocularis calpain family protein 1, d 0.2603 0.5098 0.5098
Leishmania major calpain protease-like protein 0.0387 0.0718 0.165
Trypanosoma brucei metacaspase MCA2 0.0086 0.0125 0.0286
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0162 0.0273 0.1488
Onchocerca volvulus Peroxidasin homolog 0.017 0.0289 0.0664
Trypanosoma brucei mitochondrial calcium uptake 1 0.0216 0.0381 0.0874
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0826 0.1587 0.1587
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0162 0.0273 0.076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5083 1 1
Trypanosoma brucei hypothetical protein 0.0387 0.0718 0.165
Trypanosoma cruzi cruzipain precursor, putative 0.1572 0.3061 0.3061
Trypanosoma cruzi kinesin, putative 0.0939 0.181 0.1809
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.0223 0.0511
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.0038 0.0038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.003 0.0079
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Plasmodium falciparum serine repeat antigen 9 0.0389 0.0723 0.2533
Giardia lamblia Cathepsin B precursor 0.1841 0.3592 1
Schistosoma mansoni z-protein (S1r protein) 0.0043 0.0038 0.0038
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.0223 0.0602
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0063 0.0078 0.0078
Echinococcus multilocularis peroxidasin 0.017 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.01 0.0152 0.0152
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0038 0.0038
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.0038 0.0038
Schistosoma mansoni calcium binding atopy-related autoantigen 0.022 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0043 0.0038 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0045 0.0045
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0718 0.0718
Trichomonas vaginalis calpain, putative 0.0387 0.0718 0.1999
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0389 0.0723 0.2013
Leishmania major proteasome beta 5 subunit, putative 0.0162 0.0273 0.0628
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0092 0.0135 0.0375
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1326 0.2574 0.2574
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0046 0.0045 0.0157
Trichomonas vaginalis histone deacetylase, putative 0.0092 0.0135 0.0375
Loa Loa (eye worm) PXA domain-containing protein 0.0043 0.0038 0.0038
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0028 0.0028
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.0038 0.0038
Trichomonas vaginalis calmodulin, putative 0.0216 0.0381 0.1059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0723 0.0723
Onchocerca volvulus Prolyl endopeptidase homolog 0.2226 0.4353 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0014
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.0013 0.0013
Loa Loa (eye worm) AStacin protease 0.0029 0.0012 0.0012
Echinococcus granulosus calpain A 0.3762 0.7388 0.7388
Plasmodium vivax unspecified product 0.0389 0.0723 0.2533
Brugia malayi hypothetical protein 0.0363 0.0671 0.0671
Brugia malayi hypothetical protein 0.0043 0.0038 0.0038
Echinococcus granulosus cathepsin L 0.0389 0.0723 0.0723
Schistosoma mansoni cathepsin F (C01 family) 0.103 0.199 0.199
Echinococcus multilocularis tumor protein p63 0.0376 0.0697 0.0697
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Trypanosoma brucei Metacaspase-4 0.0086 0.0125 0.0286
Echinococcus granulosus histone deacetylase 8 0.0044 0.0041 0.0041
Giardia lamblia Transglutaminase/protease, putative 0.03 0.0546 0.152
Echinococcus multilocularis glycogen phosphorylase 0.0115 0.0182 0.0182
Toxoplasma gondii prolyl endopeptidase 0.2226 0.4353 1
Echinococcus multilocularis cathepsin b 0.5083 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.0723 0.2013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Onchocerca volvulus 0.0038 0.0028 0.0064
Plasmodium vivax SET domain protein, putative 0.0097 0.0146 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0038 0.0106
Loa Loa (eye worm) histone deacetylase 0.0103 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0046 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0043 0.0043
Trypanosoma brucei Component of motile flagella 41 0.0216 0.0381 0.0874
Echinococcus granulosus calpain 5 0.1326 0.2574 0.2574
Onchocerca volvulus 0.01 0.0152 0.035
Echinococcus granulosus centrin 2 0.0216 0.0381 0.038
Loa Loa (eye worm) fibroinase 0.1467 0.2854 0.2854
Toxoplasma gondii histone deacetylase HDAC4 0.0044 0.0041 0.0094
Entamoeba histolytica protein kinase, putative 0.0939 0.181 0.6341
Echinococcus multilocularis histone deacetylase 6 0.0103 0.0157 0.0157
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0216 0.0381 0.1333
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0389 0.0723 0.2013
Plasmodium falciparum serine repeat antigen 2 0.0389 0.0723 0.2533
Echinococcus multilocularis Regulator of G protein signaling 20 0.0043 0.0038 0.0038
Leishmania major calmodulin-like protein 0.0216 0.0381 0.0874
Loa Loa (eye worm) hypothetical protein 0.0044 0.0041 0.0041
Toxoplasma gondii troponin c, isotype gamma, putative 0.0216 0.0381 0.0874
Brugia malayi Thioredoxin family protein 0.03 0.0546 0.0546
Trichomonas vaginalis histone deacetylase, putative 0.0092 0.0135 0.0375
Schistosoma mansoni neuronal calcium sensor 0.0216 0.0381 0.0381
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0001 0.0001
Onchocerca volvulus 0.0764 0.1464 0.3363
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0001 0.0001
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.1171 0.2268 0.2268
Echinococcus multilocularis gamma secretase subunit aph 1 0.0261 0.0469 0.0469
Trypanosoma brucei prolyl oligopeptidase, putative 0.0952 0.1836 0.4219
Loa Loa (eye worm) prolyl oligopeptidase 0.1182 0.229 0.229
Entamoeba histolytica cysteine proteinase, putative 0.0826 0.1587 0.556
Leishmania major histone deacetylase, putative 0.0092 0.0135 0.031
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.003 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0223 0.1211
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0014
Giardia lamblia Cathepsin B precursor 0.0389 0.0723 0.2013
Entamoeba histolytica grainin 2 0.0223 0.0395 0.1384
Leishmania major phospholipase c-like protein 0.0216 0.0381 0.0874
Plasmodium falciparum plasmepsin IX 0.0109 0.017 0.0595
Trypanosoma brucei histone deacetylase 4 0.0103 0.0157 0.0361
Onchocerca volvulus Deterin homolog 0.0176 0.0302 0.0694
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0826 0.1587 0.1587
Trypanosoma cruzi metacaspase 5, putative 0.0086 0.0125 0.0125
Onchocerca volvulus 0.017 0.0289 0.0664
Onchocerca volvulus 0.103 0.199 0.4572
Brugia malayi hypothetical protein 0.003 0.0014 0.0014
Chlamydia trachomatis glycogen phosphorylase 0.0115 0.0182 0.5
Onchocerca volvulus Cathepsin L homolog 0.1467 0.2854 0.6556
Trypanosoma brucei calpain-like protein, putative 0.1326 0.2574 0.5913
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0095 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.01 0.0152 0.0152
Plasmodium falciparum proteasome subunit beta type-5 0.0162 0.0273 0.0957
Trichomonas vaginalis calmodulin, putative 0.0216 0.0381 0.1059
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0176 0.0302 0.0302
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0216 0.0381 0.1333
Trypanosoma cruzi major cysteine proteinase, putative 0.0389 0.0723 0.0723
Entamoeba histolytica hypothetical protein 0.0043 0.0038 0.0134
Trypanosoma brucei centrin, putative 0.0216 0.0381 0.0874
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0035 0.0024 0.0054
Echinococcus multilocularis caspase 3 0.0142 0.0234 0.0234
Mycobacterium ulcerans transglutaminase family protein 0.03 0.0546 0.2973
Onchocerca volvulus Histone deacetylase 10 homolog 0.0044 0.0041 0.0094
Trichomonas vaginalis calpain, putative 0.0387 0.0718 0.1999
Schistosoma mansoni cathepsin F (C01 family) 0.1467 0.2854 0.2854
Schistosoma mansoni cathepsin B (C01 family) 0.0389 0.0723 0.0723
Echinococcus multilocularis prolyl endopeptidase 0.2226 0.4353 0.4353
Echinococcus granulosus enteropeptidase 0.01 0.0152 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0144 0.0144
Schistosoma mansoni cathepsin D (A01 family) 0.0122 0.0196 0.0196
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0389 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0071 0.0093 0.0093
Onchocerca volvulus Cell death protein 3 homolog 0.026 0.0467 0.1073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0028 0.0028
Brugia malayi Cathepsin L-like precursor 0.1467 0.2854 0.2854
Entamoeba histolytica glycogen phosphorylase, putative 0.0115 0.0182 0.0637
Schistosoma mansoni cpg binding protein 0.0062 0.0076 0.0076
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Plasmodium vivax aspartyl protease, putative 0.0109 0.017 0.0595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Trypanosoma cruzi prolyl endopeptidase 0.2226 0.4353 0.4353
Schistosoma mansoni histone deacetylase hda2 0.0109 0.017 0.017
Trypanosoma brucei Calpain-like protein CALP1.3 0.0387 0.0718 0.165
Echinococcus multilocularis cathepsin b 0.5083 1 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.003 0.0014 0.0032
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0038 0.0038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1326 0.2574 0.2574
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0718 0.1999
Trichomonas vaginalis calmodulin, putative 0.0216 0.0381 0.1059
Leishmania major oligopeptidase b 0.0952 0.1836 0.4219
Onchocerca volvulus 0.003 0.0013 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0334 0.0613 0.2148
Brugia malayi A-kinase anchor protein 10, precursor 0.0043 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.0381 0.0874
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Onchocerca volvulus Cathepsin L homolog 0.1467 0.2854 0.6556
Brugia malayi hypothetical protein 0.0173 0.0297 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) hypothetical protein 0.0216 0.0381 0.0381
Onchocerca volvulus Cathepsin F homolog 0.1467 0.2854 0.6556
Trypanosoma brucei I/6 autoantigen 0.0216 0.0381 0.0874
Echinococcus granulosus EF HAND 1 calcium binding site 0.0216 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.2226 0.4353 0.4353
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0144 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Echinococcus multilocularis cathepsin L cysteine protease 0.1467 0.2854 0.2854
Echinococcus granulosus calumenin 0.022 0.0388 0.0388
Echinococcus granulosus neurocalcin 0.0216 0.0381 0.038
Trichomonas vaginalis calcineurin B subunit, putative 0.0216 0.0381 0.1059
Toxoplasma gondii histone deacetylase HDAC2 0.0092 0.0135 0.031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0097 0.0146 0.0146
Schistosoma mansoni Mername-AA248 (C02 family) 0.1326 0.2574 0.2574
Trypanosoma cruzi centrin, putative 0.0223 0.0395 0.0395
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0028 0.0076
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0063 0.0078 0.0078
Leishmania major calcineurin B subunit, putative 0.0216 0.0381 0.0874
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0216 0.0381 0.0874
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0028
Toxoplasma gondii EF hand domain-containing protein 0.0216 0.0381 0.0874
Schistosoma mansoni calmodulin related calcium binding protein 0.0216 0.0381 0.0381
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0176 0.0302 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0144 0.0144
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) trypsin family protein 0.01 0.0152 0.0152
Toxoplasma gondii hypothetical protein 0.003 0.0013 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0387 0.0718 0.0718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Trypanosoma cruzi oligopeptidase b 0.0952 0.1836 0.1836
Echinococcus multilocularis calpain A 0.3762 0.7388 0.7388
Trypanosoma cruzi histone deacetylase, putative 0.0103 0.0157 0.0157
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.01 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0125 0.0347
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0024 0.0128
Mycobacterium ulcerans beta-lactamase 0.0038 0.0028 0.0152
Onchocerca volvulus 0.0216 0.0381 0.0874
Plasmodium falciparum plasmepsin I 0.003 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0047 0.0047 0.0047
Entamoeba histolytica calmodulin, putative 0.0216 0.0381 0.1333
Brugia malayi beta-lactamase 0.0038 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0038 0.0038
Onchocerca volvulus 0.1467 0.2854 0.6556
Brugia malayi calpain family protein 1 0.3542 0.6954 0.6954
Brugia malayi Cathepsin L-like cysteine proteinase 0.103 0.199 0.199
Plasmodium falciparum plasmepsin VIII, putative 0.003 0.0014 0.0049
Schistosoma mansoni cathepsin F (C01 family) 0.1467 0.2854 0.2854
Loa Loa (eye worm) hypothetical protein 0.0216 0.0381 0.0381
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1182 0.229 0.2289
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0389 0.0723 0.2533
Schistosoma mansoni hypothetical protein 0.0387 0.0718 0.0718
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0069 0.0069
Plasmodium falciparum cysteine repeat modular protein 1 0.0046 0.0045 0.0157
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0334 0.0613 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Schistosoma mansoni hypothetical protein 0.0216 0.0381 0.0381
Echinococcus granulosus calpain A 0.1326 0.2574 0.2574
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1182 0.229 0.526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Schistosoma mansoni hypothetical protein 0.0054 0.0061 0.0061
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0092 0.0135 0.0375
Brugia malayi Serine protease Z688.6 precursor 0.0063 0.0078 0.0078
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.003 0.0082
Echinococcus granulosus calcium uptake protein 1 0.022 0.0388 0.0388
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1572 0.3061 0.7032
Plasmodium vivax serine-repeat antigen (SERA) 0.0389 0.0723 0.2533
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0016
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.0038 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.1587 0.3645
Brugia malayi regulator of G-protein signaling rgs-7 0.0043 0.0038 0.0038
Mycobacterium leprae Conserved hypothetical protein 0.03 0.0546 0.2973
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0005 0.0004
Brugia malayi CXXC zinc finger family protein 0.0058 0.0069 0.0069
Onchocerca volvulus 0.003 0.0013 0.0029
Echinococcus granulosus transmembrane protease serine 3 0.01 0.0152 0.0152
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0254 0.0707
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0097 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0723 0.2013
Schistosoma mansoni memapsin-2 (A01 family) 0.0491 0.0924 0.0924
Giardia lamblia Histone deacetylase 0.0092 0.0135 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1841 0.3592 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0038 0.0028 0.0076
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.0013 0.0013
Echinococcus multilocularis caspase 2 0.026 0.0467 0.0467
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0092 0.0135 0.0375
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0095 0.0143 0.0386
Toxoplasma gondii microneme protein MIC17A 0.003 0.0013 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0038 0.0106
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0086 0.0125 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0097 0.0146 0.0336
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0334 0.0613 0.1707
Echinococcus multilocularis EF hand domain containing family member A2 0.0216 0.0381 0.038
Onchocerca volvulus 0.003 0.0013 0.0029
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0047 0.0046 0.0046
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1467 0.2854 0.2854
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1892 0.3694 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0723 0.2013
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0176 0.0302 0.0302
Plasmodium vivax calpain, putative 0.1326 0.2574 0.9018
Brugia malayi hypothetical protein 0.0168 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0069 0.0069
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0152 0.0152
Toxoplasma gondii cathepsin CPL 0.1467 0.2854 0.6556
Loa Loa (eye worm) hypothetical protein 0.0071 0.0093 0.0093
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0216 0.0381 0.038
Giardia lamblia Proteasome subunit beta type 1 0.0077 0.0106 0.0295
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0014 0.0014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0061 0.0061
Toxoplasma gondii 1,3(4)-beta-glucanase 0.003 0.0013 0.0029
Brugia malayi PXA domain containing protein 0.0043 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0723 0.2013
Loa Loa (eye worm) hypothetical protein 0.017 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.03 0.0546 0.0546
Echinococcus granulosus calpain 7 C02 family 0.1326 0.2574 0.2574
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0063 0.0078 0.0078
Toxoplasma gondii peptidase family M13 protein 0.0095 0.0143 0.0327
Giardia lamblia Cathepsin L precursor 0.0389 0.0723 0.2013
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0063 0.0078 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0024 0.0024
Onchocerca volvulus 0.003 0.0013 0.0029
Plasmodium vivax vivapain-2 0.1467 0.2854 1
Schistosoma mansoni histone deacetylase 0.0092 0.0135 0.0135
Onchocerca volvulus 0.01 0.0152 0.035
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.022 0.0388 0.0388
Onchocerca volvulus 0.0216 0.0381 0.0874
Giardia lamblia Alanyl dipeptidyl peptidase 0.0334 0.0613 0.1707
Echinococcus multilocularis microtubule associated protein 2 0.1536 0.2989 0.2989
Trypanosoma cruzi histone deacetylase 1, putative 0.0092 0.0135 0.0135
Mycobacterium ulcerans hypothetical protein 0.03 0.0546 0.2973
Toxoplasma gondii PAN domain-containing protein 0.003 0.0013 0.0029
Brugia malayi cathepsin L precursor 0.0389 0.0723 0.0723
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0334 0.0613 0.2148
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0125 0.0347
Onchocerca volvulus 0.1467 0.2854 0.6556
Toxoplasma gondii subtilisin SUB12 0.003 0.0013 0.0029
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0389 0.0723 0.2013
Schistosoma mansoni calpain C (C02 family) 0.1326 0.2574 0.2574
Entamoeba histolytica hypothetical protein, conserved 0.022 0.0388 0.136
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0063 0.0078 0.0218
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0152 0.0152
Brugia malayi hypothetical protein 0.01 0.0152 0.0152
Entamoeba histolytica histone deacetylase, putative 0.0092 0.0135 0.0473
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0162 0.0273 0.0273
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0373 0.0691 0.0691
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0028 0.0028
Entamoeba histolytica cysteine protease, putative 0.0389 0.0723 0.2533
Giardia lamblia Hypothetical protein 0.022 0.0388 0.1081
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0024 0.0065
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.003 0.0029
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.1467 0.2854 0.2854
Brugia malayi Calmodulin-like protein 0.0216 0.0381 0.0381
Leishmania major calmodulin, putative 0.0216 0.0381 0.0874
Onchocerca volvulus 0.0046 0.0045 0.0103
Onchocerca volvulus 0.01 0.0152 0.035
Plasmodium falciparum plasmepsin VI 0.003 0.0014 0.0049
Brugia malayi Animal haem peroxidase family protein 0.017 0.0289 0.0289
Onchocerca volvulus 0.0047 0.0047 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0723 0.2013
Echinococcus granulosus cathepsin l cysteine peptidase 0.1467 0.2854 0.2854
Brugia malayi prolyl oligopeptidase family protein 0.2226 0.4353 0.4353
Brugia malayi PAN domain containing protein 0.003 0.0013 0.0013
Trichomonas vaginalis myosin light chain 1, putative 0.0216 0.0381 0.1059
Leishmania major cathepsin L-like protease 0.1572 0.3061 0.7032
Trypanosoma cruzi metacaspase, putative 0.0086 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0065 0.0083 0.0083
Brugia malayi hypothetical protein 0.003 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0216 0.0381 0.0381
Brugia malayi histone deacetylase 11 0.0044 0.0041 0.0041
Echinococcus granulosus calpain 0.1326 0.2574 0.2574
Onchocerca volvulus 0.0054 0.0061 0.014
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0024 0.0024
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.5083 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0718 0.0718
Mycobacterium ulcerans hypothetical protein 0.03 0.0546 0.2973
Brugia malayi Trypsin-like protease protein 5 0.01 0.0152 0.0152
Entamoeba histolytica cysteine protease, putative 0.0389 0.0723 0.2533
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0723 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1467 0.2854 0.7944
Leishmania major proteasome beta 2 subunit, putative 0.005 0.0052 0.0119
Plasmodium falciparum plasmepsin X 0.0109 0.017 0.0595
Loa Loa (eye worm) hypothetical protein 0.01 0.0152 0.0152
Echinococcus multilocularis cysteine protease 0.1467 0.2854 0.2854
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0254 0.0707
Brugia malayi Papain family cysteine protease containing protein 0.0826 0.1587 0.1587
Brugia malayi hypothetical protein 0.0043 0.0038 0.0038
Trypanosoma brucei C-8 sterol isomerase, putative 0.0373 0.0691 0.1588
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0718 0.165
Leishmania major histone deacetylase, putative 0.0092 0.0135 0.031
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0216 0.0381 0.038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.003 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0723 0.2013
Echinococcus granulosus gamma secretase subunit aph 1 0.0261 0.0469 0.0469
Trypanosoma brucei cysteine peptidase, putative 0.0387 0.0718 0.165
Loa Loa (eye worm) hypothetical protein 0.0095 0.0143 0.0143
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0216 0.0381 0.1059
Brugia malayi prolyl oligopeptidase family protein 0.1182 0.229 0.229
Brugia malayi prolyl oligopeptidase family protein 0.0914 0.1761 0.1761
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0028 0.0076
Brugia malayi programmed cell death protein 6 0.0216 0.0381 0.0381
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0001 0.0001
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0152 0.0254 0.0707
Onchocerca volvulus Peroxidase homolog 0.017 0.0289 0.0664
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1135 0.2197 0.2197
Toxoplasma gondii centrin, putative 0.0216 0.0381 0.0874

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.16 uM Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5 ChEMBL. 16213722
IC50 (functional) = 2.16 uM Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5 ChEMBL. 16213722

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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