Detailed information for compound 372955

Basic information

Technical information
  • TDR Targets ID: 372955
  • Name: 6-(4-chlorophenyl)-3-[[3-[(4-hydroxypiperidin -1-yl)methyl]quinolin-8-yl]methyl]thieno[3,2- d]pyrimidin-4-one
  • MW: 517.042 | Formula: C28H25ClN4O2S
  • H donors: 1 H acceptors: 3 LogP: 4.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC1CCN(CC1)Cc1cnc2c(c1)cccc2Cn1cnc2c(c1=O)sc(c2)c1ccc(cc1)Cl
  • InChi: 1S/C28H25ClN4O2S/c29-22-6-4-19(5-7-22)25-13-24-27(36-25)28(35)33(17-31-24)16-21-3-1-2-20-12-18(14-30-26(20)21)15-32-10-8-23(34)9-11-32/h1-7,12-14,17,23,34H,8-11,15-16H2
  • InChiKey: DOSLTOINSAMWEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-chlorophenyl)-3-[[3-[(4-hydroxy-1-piperidyl)methyl]-8-quinolyl]methyl]thieno[3,2-d]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[[3-[(4-hydroxy-1-piperidinyl)methyl]-8-quinolyl]methyl]-4-thieno[3,2-d]pyrimidinone
  • 6-(4-chlorophenyl)-3-[[3-[(4-hydroxypiperidino)methyl]-8-quinolyl]methyl]thieno[3,2-d]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[[3-[(4-hydroxypiperidin-1-yl)methyl]quinolin-8-yl]methyl]thieno[2,3-e]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[[3-[(4-hydroxy-1-piperidyl)methyl]-8-quinolyl]methyl]thieno[2,3-e]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[[3-[(4-hydroxy-1-piperidinyl)methyl]-8-quinolyl]methyl]-4-thieno[2,3-e]pyrimidinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPI anchor transamidase 0.0034 0.002 0.0028
Brugia malayi cathepsin Z-like cysteine proteinase 0.0248 0.0671 0.0671
Trichomonas vaginalis calcium binding protein, putative 0.0109 0.0248 0.0795
Echinococcus granulosus slit 2 protein 0.0044 0.0051 0.0072
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0856 0.2513 0.4494
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0038 0.0053
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.0026 0.0022
Brugia malayi calpain D 0.0223 0.0592 0.0592
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0034 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0126 0.0301 0.0423
Brugia malayi Calcium binding EGF domain containing protein 0.0044 0.0051 0.0051
Onchocerca volvulus 0.0057 0.009 0.013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Plasmodium falciparum serine repeat antigen 8 0.0248 0.0671 0.215
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Leishmania major cathepsin L-like protease 0.1055 0.3119 0.4939
Onchocerca volvulus Slit protein homolog 0.0044 0.0051 0.0069
Echinococcus granulosus flap endonuclease 1 0.0028 0.0002 0.0003
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0507 0.0713
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Toxoplasma gondii EGF family domain-containing protein 0.0044 0.0051 0.0081
Schistosoma mansoni ap endonuclease 0.006 0.0098 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Echinococcus multilocularis 0.0036 0.0026 0.0036
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3425
Schistosoma mansoni caspase-3 (C14 family) 0.0102 0.0227 0.0318
Onchocerca volvulus 0.1055 0.3119 0.4932
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0038 0.0053
Giardia lamblia Cysteine protease 0.0248 0.0671 0.2511
Brugia malayi Papain family cysteine protease containing protein 0.0576 0.1663 0.1663
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.1055 0.3119 0.3119
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0053
Brugia malayi programmed cell death protein 6 0.0109 0.0248 0.0248
Echinococcus granulosus calpain 7 C02 family 0.074 0.2163 0.3039
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0575 0.1662 0.2622
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Schistosoma mansoni hypothetical protein 0.0165 0.0416 0.0585
Onchocerca volvulus 0.0035 0.0023 0.0024
Onchocerca volvulus 0.0044 0.0051 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Brugia malayi EGF-like domain containing protein 0.0044 0.0051 0.0051
Trypanosoma brucei centrin-3 0.0109 0.0248 0.0393
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.0606 0.0606
Brugia malayi cathepsin B-like cysteine proteinase 0.2373 0.7117 0.7117
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0248 0.0671 0.2145
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Trichomonas vaginalis calcineurin B subunit, putative 0.011 0.0252 0.0809
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1055 0.3119 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0251 0.0353
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0658 0.1915 0.1915
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.005 0.008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0255 0.0404
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Trichomonas vaginalis ran, putative 0.0044 0.005 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Brugia malayi Cadherin domain containing protein 0.0044 0.0051 0.0051
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0021 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0294 0.0414
Echinococcus multilocularis calpain A 0.2073 0.6206 0.8719
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0071 0.0132 0.0418
Giardia lamblia Cathepsin B precursor 0.0248 0.0671 0.2511
Trichomonas vaginalis esterase, putative 0.011 0.0251 0.0806
Toxoplasma gondii calcium-dependent protein kinase 0.011 0.0252 0.0399
Toxoplasma gondii proteasome subunit beta type, putative 0.0158 0.0397 0.0628
Brugia malayi Papain family cysteine protease containing protein 0.0576 0.1663 0.1663
Entamoeba histolytica protein kinase, putative 0.0518 0.1488 0.4767
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0083
Brugia malayi Animal haem peroxidase family protein 0.0502 0.1441 0.1441
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0338 0.0943 0.1325
Plasmodium vivax unspecified product 0.0327 0.091 0.2917
Brugia malayi Peptidase C13 family protein 0.0146 0.036 0.036
Echinococcus granulosus neuronal calcium sensor 0.0109 0.0248 0.0348
Schistosoma mansoni hypothetical protein 0.0044 0.0051 0.0072
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0109 0.0248 0.0393
Brugia malayi gamma-secretase subunit aph-1 0.0239 0.0642 0.0642
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.0026 0.0022
Trypanosoma cruzi I/6 autoantigen, putative 0.0109 0.0248 0.0348
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Brugia malayi beta-lactamase family protein 0.011 0.0251 0.0251
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0026 0.0036
Onchocerca volvulus 0.011 0.0252 0.0387
Plasmodium falciparum serine repeat antigen 2 0.0248 0.0671 0.215
Echinococcus multilocularis neurogenic locus notch protein 4 0.0044 0.0051 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Giardia lamblia Transglutaminase/protease, putative 0.0035 0.0023 0.0078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.0671 0.0942
Plasmodium vivax vivapain-2 0.1055 0.3119 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0038 0.0121
Mycobacterium ulcerans hypothetical protein 0.0126 0.0301 0.1125
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.0026 0.001
Echinococcus multilocularis programmed cell death protein 0.0109 0.0248 0.0348
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0109 0.0248 0.0348
Trypanosoma cruzi oligopeptidase b 0.0856 0.2513 0.3532
Leishmania major calpain family cysteine protease-like protein 0.0223 0.0592 0.0938
Brugia malayi Cathepsin L-like precursor 0.1055 0.3119 0.3119
Schistosoma mansoni hypothetical protein 0.0126 0.0301 0.0423
Echinococcus granulosus glycoprotein Antigen 5 0.0126 0.0301 0.0423
Onchocerca volvulus Peroxidase homolog 0.0502 0.1441 0.2272
Trichomonas vaginalis calcineurin B subunit, putative 0.0109 0.0248 0.0795
Entamoeba histolytica hypothetical protein 0.004 0.0038 0.0115
Echinococcus granulosus cpg binding protein 0.006 0.01 0.014
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0856 0.2513 0.3532
Loa Loa (eye worm) hypothetical protein 0.0048 0.0064 0.0064
Brugia malayi EGF-like domain containing protein 0.0044 0.0051 0.0051
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0109 0.0248 0.0348
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0856 0.2513 0.3532
Brugia malayi GPI-anchor transamidase 0.0034 0.002 0.002
Onchocerca volvulus 0.1055 0.3119 0.4932
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.0592 0.0832
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Trypanosoma cruzi calmodulin, putative 0.0109 0.0248 0.0348
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0034 0.0021 0.0032
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0071 0.0132 0.0186
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0158 0.0397 0.0628
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0038 0.0053
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0102 0.0227 0.0318
Trypanosoma brucei I/6 autoantigen 0.0109 0.0248 0.0393
Plasmodium vivax proteasome subunit beta type-1, putative 0.0071 0.0132 0.0425
Giardia lamblia Cathepsin B precursor 0.0248 0.0671 0.2511
Trypanosoma brucei centrin, putative 0.0109 0.0248 0.0393
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0906 0.2665 0.3744
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0126 0.0301 0.0423
Leishmania major sir2-family protein-like protein 0.0034 0.0021 0.0032
Entamoeba histolytica cysteine protease, putative 0.0248 0.0671 0.2145
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0058 0.0081
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0251 0.0416
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0248 0.0671 0.0671
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0034 0.0021 0.0066
Echinococcus multilocularis notch 0.0044 0.0051 0.0072
Echinococcus granulosus lamin dm0 0.0054 0.0082 0.0115
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Trichomonas vaginalis calcium binding protein, putative 0.0109 0.0248 0.0795
Trichomonas vaginalis calcium binding proteins, putative 0.0109 0.0248 0.0795
Echinococcus multilocularis survival motor neuron protein 1 0.0491 0.1406 0.1976
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0225 0.0316
Plasmodium vivax SET domain protein, putative 0.0096 0.0207 0.0664
Brugia malayi EGF-like domain containing protein 0.0044 0.0051 0.0051
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0247 0.0665 0.2133
Entamoeba histolytica grainin, putative 0.011 0.0252 0.0803
Echinococcus multilocularis neurogenic locus notch protein 0.0044 0.0051 0.0072
Onchocerca volvulus 0.1055 0.3119 0.4932
Echinococcus multilocularis calpain 0.074 0.2163 0.3039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) aspartyl protease 6 0.0055 0.0083 0.0083
Toxoplasma gondii peptidase c13 family protein 0.0034 0.002 0.0032
Brugia malayi cathepsin L precursor 0.0248 0.0671 0.0671
Brugia malayi proteasome subunit beta type 2 0.0046 0.0057 0.0057
Onchocerca volvulus Chorion peroxidase homolog 0.0502 0.1441 0.2272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Echinococcus multilocularis calumenin 0.011 0.0252 0.0354
Echinococcus granulosus caspase 2 0.0057 0.0091 0.0127
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0064 0.0204
Trypanosoma cruzi cysteine peptidase, putative 0.1153 0.3415 0.4798
Trypanosoma cruzi major cysteine proteinase, putative 0.0346 0.0967 0.1358
Echinococcus multilocularis transmembrane protease serine 3 0.0126 0.0301 0.0423
Schistosoma mansoni axis inhibition protein axin 0.004 0.0038 0.0053
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0158 0.0397 0.1482
Trypanosoma brucei mitochondrial calcium uptake 1 0.0109 0.0248 0.0393
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0132 0.0319 0.1016
Echinococcus multilocularis calpain 7 (C02 family) 0.074 0.2163 0.3039
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0301 0.0423
Schistosoma mansoni lamin 0.0054 0.0082 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.0026 0.001
Echinococcus granulosus calpain 0.074 0.2163 0.3039
Brugia malayi proteasome subunit beta type 1 0.0071 0.0132 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0251 0.0806
Leishmania major calcineurin B subunit, putative 0.0109 0.0248 0.0393
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.0026 0.0022
Plasmodium falciparum plasmepsin VI 0.0055 0.0083 0.0267
Schistosoma mansoni hypothetical protein 0.0044 0.0051 0.0072
Echinococcus granulosus EF hand domain containing family member A2 0.0109 0.0248 0.0348
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0158 0.0397 0.1266
Echinococcus multilocularis proteasome (prosome, macropain) 0.0158 0.0397 0.0557
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2373 0.7117 1
Plasmodium falciparum serine repeat antigen 6 0.0248 0.0671 0.215
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.1174 0.1649
Onchocerca volvulus Peroxidase homolog 0.0502 0.1441 0.2272
Loa Loa (eye worm) hypothetical protein 0.0068 0.0123 0.0123
Schistosoma mansoni cathepsin C 0.0248 0.0671 0.0942
Giardia lamblia Transcriptional regulator, Sir2 family 0.0034 0.0021 0.0069
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0247 0.0665 0.2133
Onchocerca volvulus 0.0096 0.0207 0.0316
Trypanosoma cruzi cysteine proteinase, putative 0.0576 0.1663 0.2337
Loa Loa (eye worm) calpain D 0.0223 0.0592 0.0592
Brugia malayi transcriptional regulator, Sir2 family protein 0.0034 0.0021 0.0021
Loa Loa (eye worm) EF hand family protein 0.0109 0.0248 0.0248
Schistosoma mansoni cathepsin D (A01 family) 0.0361 0.1014 0.1425
Toxoplasma gondii aspartyl protease ASP3 0.0318 0.0881 0.1395
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0077 0.0109
Onchocerca volvulus 0.01 0.0221 0.0338
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.1663 0.533
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Echinococcus granulosus EF HAND 1 calcium binding site 0.0109 0.0248 0.0348
Entamoeba histolytica GPI-anchor transamidase, putative 0.0034 0.002 0.0058
Brugia malayi calpain 5 0.0518 0.1488 0.1488
Leishmania major cytochrome p450-like protein 0.0063 0.0108 0.0171
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0248 0.0671 0.215
Brugia malayi cathepsin F-like cysteine proteinase 0.0327 0.091 0.091
Echinococcus granulosus neurocalcin 0.0109 0.0248 0.0348
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0038 0.0038
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0021 0.0029
Onchocerca volvulus 0.0502 0.1441 0.2272
Mycobacterium tuberculosis Probable peptidase 0.0856 0.2513 0.4494
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0064 0.0064
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0248 0.0671 0.0942
Brugia malayi hypothetical protein 0.0055 0.0083 0.0083
Brugia malayi Calcium binding EGF domain containing protein 0.0044 0.0051 0.0051
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.1663 0.533
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0248 0.0671 0.215
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.074 0.2163 0.3039
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0034 0.002 0.0028
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0223 0.0592 0.1899
Echinococcus granulosus calumenin 0.011 0.0252 0.0354
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0826 0.2422 0.3404
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.0026 0.001
Onchocerca volvulus 0.1055 0.3119 0.4932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.0606 0.0851
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Schistosoma mansoni laminin gamma-3 chain 0.0044 0.0051 0.0072
Brugia malayi PXA domain containing protein 0.004 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.0671 0.215
Leishmania major hypothetical protein, conserved 0.0109 0.0248 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.0026 0.0022
Mycobacterium ulcerans beta-lactamase 0.011 0.0251 0.0926
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.0592 0.0832
Echinococcus multilocularis protein jagged 1 0.0044 0.0051 0.0072
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0248 0.0671 0.215
Loa Loa (eye worm) hypothetical protein 0.0248 0.0671 0.0671
Onchocerca volvulus 0.0502 0.1441 0.2272
Loa Loa (eye worm) hypothetical protein 0.0092 0.0195 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.0606 0.0851
Echinococcus multilocularis programmed cell death protein 0.0109 0.0248 0.0348
Plasmodium falciparum calpain 0.0223 0.0592 0.1899
Brugia malayi EGF-like domain containing protein 0.0044 0.0051 0.0051
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0034 0.002 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.0576 0.1663 0.2337
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0251 0.0398
Brugia malayi cathepsin L-like cysteine proteinase 0.0248 0.0671 0.0671
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0098 0.0155
Loa Loa (eye worm) animal heme peroxidase 0.0502 0.1441 0.1441
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0002 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0251 0.0416
Giardia lamblia Cathepsin B precursor 0.0248 0.0671 0.2511
Echinococcus granulosus cathepsin l cysteine peptidase 0.1055 0.3119 0.4382
Echinococcus multilocularis chromatin regulatory protein sir2 0.0132 0.0319 0.0448
Echinococcus multilocularis lamin 0.0054 0.0082 0.0115
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0251 0.0806
Schistosoma mansoni hypothetical protein 0.0165 0.0416 0.0585
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0058 0.0081
Trypanosoma cruzi kinesin, putative 0.0518 0.1488 0.2091
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0301 0.1126
Mycobacterium leprae Probable lipase LipE 0.011 0.0251 0.0917
Echinococcus multilocularis GPI anchor transamidase 0.0034 0.002 0.0028
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0109 0.0248 0.0348
Echinococcus multilocularis protein jagged 1 0.0044 0.0051 0.0072
Mycobacterium ulcerans putative transglutaminase-like protein 0.0035 0.0023 0.001
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0575 0.1662 0.2335
Brugia malayi hypothetical protein 0.004 0.0038 0.0038
Brugia malayi Animal haem peroxidase family protein 0.0502 0.1441 0.1441
Giardia lamblia High cysteine protein 0.0044 0.0051 0.0185
Giardia lamblia Encystation-specific protease 0.0248 0.0671 0.2511
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0058 0.0081
Onchocerca volvulus Huntingtin homolog 0.0127 0.0303 0.0468
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0248 0.0671 0.2145
Entamoeba histolytica Ran family GTPase 0.0044 0.005 0.0154
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0058 0.0081
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0038 0.0053
Plasmodium falciparum proteasome subunit beta type-5 0.0158 0.0397 0.1272
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0248 0.0671 0.215
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0247 0.0665 0.2127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Loa Loa (eye worm) fibroinase 0.1055 0.3119 0.3119
Loa Loa (eye worm) hypothetical protein 0.0126 0.0301 0.0301
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0109 0.0248 0.0789
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0856 0.2513 1
Echinococcus granulosus prolyl endopeptidase 0.2109 0.6316 0.8874
Loa Loa (eye worm) hypothetical protein 0.0112 0.0258 0.0258
Brugia malayi Cathepsin L-like precursor 0.1055 0.3119 0.3119
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0082 0.0082
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Toxoplasma gondii aspartyl protease ASP1 0.0055 0.0083 0.0132
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0251 0.0416
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0856 0.2513 0.398
Plasmodium falciparum cysteine proteinase falcipain 3 0.1055 0.3119 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.0026 0.0022
Echinococcus granulosus cathepsin l1 0.0728 0.2126 0.2988
Schistosoma mansoni hemoglobinase (C13 family) 0.0146 0.036 0.0506
Schistosoma mansoni hypothetical protein 0.0092 0.0195 0.0274
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0018
Trichomonas vaginalis myosin light chain 1, putative 0.0109 0.0248 0.0795
Loa Loa (eye worm) peptidase C13 family protein 0.0146 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0128
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.0026 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0121
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Toxoplasma gondii histone deacetylase SIR2 0.0034 0.0021 0.0032
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Loa Loa (eye worm) hypothetical protein 0.0157 0.0393 0.0393
Echinococcus granulosus Mastin 0.0126 0.0301 0.0423
Trichomonas vaginalis calpain, putative 0.0223 0.0592 0.1899
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Entamoeba histolytica calmodulin, putative 0.0109 0.0248 0.0789
Schistosoma mansoni peroxidasin 0.0502 0.1441 0.2025
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Echinococcus granulosus fibropellin Ia 0.0044 0.0051 0.0072
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0146 0.036 0.0506
Brugia malayi Pepsin A precursor 0.0055 0.0083 0.0083
Schistosoma mansoni slit 0.0044 0.0051 0.0072
Loa Loa (eye worm) hypothetical protein 0.011 0.0251 0.0251
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0576 0.1663 0.2337
Toxoplasma gondii ABC1 family protein 0.011 0.0251 0.0398
Loa Loa (eye worm) hypothetical protein 0.1222 0.3625 0.3625
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0247 0.0665 0.0935
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0046 0.0057 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0098 0.0315
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2373 0.7117 1
Plasmodium falciparum importin beta, putative 0.006 0.0098 0.0314
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Echinococcus multilocularis cathepsin L 0.0248 0.0671 0.0942
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0251 0.0806
Plasmodium falciparum serine repeat antigen 4 0.0248 0.0671 0.215
Schistosoma mansoni cathepsin S (C01 family) 0.0248 0.0671 0.0942
Leishmania major calmodulin, putative 0.0109 0.0248 0.0393
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Echinococcus multilocularis prolyl endopeptidase 0.2109 0.6316 0.8874
Loa Loa (eye worm) blistered cuticle protein 3 0.0502 0.1441 0.1441
Trypanosoma brucei calpain, putative 0.0223 0.0592 0.0938
Plasmodium falciparum plasmepsin VII 0.0055 0.0083 0.0267
Loa Loa (eye worm) prolyl oligopeptidase 0.0247 0.0665 0.0665
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0123 0.0123
Plasmodium vivax vivapain-3 0.0576 0.1663 0.5333
Trypanosoma cruzi cruzipain precursor, putative 0.1153 0.3415 0.4798
Schistosoma mansoni hypothetical protein 0.0109 0.0248 0.0348
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0251 0.0416
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0077 0.0109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0906 0.2665 0.3744
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0128
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0223 0.0592 0.0832
Echinococcus granulosus caspase 0.0102 0.0227 0.0318
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0223 0.0592 0.1899
Echinococcus granulosus neural cadherin 0.0044 0.0051 0.0072
Loa Loa (eye worm) trypsin family protein 0.0126 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0071 0.0132 0.0425
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1962 0.5871 0.8248
Trypanosoma brucei calmodulin, putative 0.0109 0.0248 0.0393
Echinococcus granulosus tumor protein p63 0.0692 0.2018 0.2835
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0098 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0906 0.2665 0.8543
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Trypanosoma cruzi prolyl endopeptidase 0.2109 0.6316 0.8874
Entamoeba histolytica cysteine protease, putative 0.0248 0.0671 0.2145
Brugia malayi Pre-SET motif family protein 0.0096 0.0207 0.0207
Schistosoma mansoni memapsin-2 (A01 family) 0.0474 0.1355 0.1904
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0132 0.0319 0.1022
Schistosoma mansoni centrin-related 0.0109 0.0248 0.0348
Onchocerca volvulus 0.0044 0.0051 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.1055 0.3119 0.3119
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Leishmania major hypothetical protein, conserved 0.011 0.0252 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.0606 0.0851
Echinococcus multilocularis calmodulin 0.0109 0.0248 0.0348
Schistosoma mansoni hypothetical protein 0.0112 0.0257 0.0362
Entamoeba histolytica cysteine protease, putative 0.0248 0.0671 0.2145
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0338 0.0943 0.1325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.1663 0.5333
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0207 0.0291
Schistosoma mansoni hypothetical protein 0.0035 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0068 0.0123 0.0123
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0046 0.0057 0.008
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1055 0.3119 0.3119
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.0026 0.0022
Plasmodium falciparum flap endonuclease 1 0.0028 0.0002 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.0671 0.215
Trypanosoma brucei centrin, putative 0.0109 0.0248 0.0393
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.0658 0.0658
Schistosoma mansoni hypothetical protein 0.0109 0.0248 0.0348
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3039
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.0671 0.0942
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.009 0.009
Giardia lamblia Cysteine protease 0.0248 0.0671 0.2511
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0251 0.0353
Trypanosoma brucei caltractin, putative 0.0109 0.0248 0.0393
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0026 0.0041
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0158 0.0397 0.0397
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0058 0.0081
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0038 0.0038
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0109 0.0248 0.0348
Onchocerca volvulus 0.0126 0.0301 0.0465
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0046 0.0057 0.0183
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0248 0.0671 0.215
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.2071 0.6201 0.8713
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Brugia malayi Trypsin family protein 0.0126 0.0301 0.0301
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0038 0.0053
Echinococcus multilocularis cpg binding protein 0.006 0.01 0.014
Loa Loa (eye worm) proteasome subunit beta type 1 0.0071 0.0132 0.0132
Trypanosoma cruzi cysteine peptidase, putative 0.1153 0.3415 0.4798
Loa Loa (eye worm) hypothetical protein 0.0092 0.0195 0.0195
Echinococcus granulosus calcium uptake protein 1 0.011 0.0252 0.0354
Entamoeba histolytica prolyl oligopeptidase family protein 0.0247 0.0665 0.2127
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Plasmodium falciparum plasmepsin IX 0.0318 0.0881 0.2824
Echinococcus granulosus axis inhibition protein axin 0.004 0.0038 0.0053
Trypanosoma brucei calpain, putative 0.0223 0.0592 0.0938
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0034 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Plasmodium vivax vivapain-2 0.1055 0.3119 1
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0146 0.0361 0.135
Leishmania major calpain protease-like protein 0.0223 0.0592 0.0938
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.0026 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.0606 0.0851
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0092 0.0195 0.0274
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Leishmania major cathepsin L-like protease 0.1055 0.3119 0.4939
Onchocerca volvulus Peroxidasin homolog 0.0502 0.1441 0.2272
Giardia lamblia Cathepsin L precursor 0.0248 0.0671 0.2511
Echinococcus multilocularis gamma secretase subunit aph 1 0.0239 0.0642 0.0902
Trypanosoma brucei cytochrome P450, putative 0.0063 0.0108 0.0171
Onchocerca volvulus 0.1055 0.3119 0.4932
Brugia malayi Papain family cysteine protease containing protein 0.0248 0.0671 0.0671
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.0026 0.001
Plasmodium falciparum plasmepsin II 0.0055 0.0083 0.0267
Trichomonas vaginalis calpain, putative 0.0223 0.0592 0.1899
Trypanosoma brucei calpain-like protein, putative 0.074 0.2163 0.3425
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Echinococcus granulosus calmodulin 0.0109 0.0248 0.0348
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.004 0.0038 0.0115
Mycobacterium ulcerans transglutaminase family protein 0.0035 0.0023 0.001
Entamoeba histolytica cysteine protease, putative 0.1055 0.3119 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0195 0.0195
Echinococcus multilocularis calmodulin 0.0109 0.0248 0.0348
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0223 0.0592 0.0938
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0301 0.1126
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0146 0.036 0.1155
Loa Loa (eye worm) hypothetical protein 0.011 0.0251 0.0251
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0021 0.0066
Trypanosoma cruzi cysteine protease, putative 0.0576 0.1663 0.2337
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.074 0.2163 0.3039
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0038 0.0038
Plasmodium vivax hypothetical protein, conserved 0.011 0.0252 0.0809
Echinococcus granulosus calpain A 0.074 0.2163 0.3039
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0146 0.036 0.1155
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Plasmodium vivax serine-repeat antigen (SERA) 0.0248 0.0671 0.215
Giardia lamblia Cysteine protease 0.0248 0.0671 0.2511
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.02 0.0281
Mycobacterium ulcerans lipase LipD 0.011 0.0251 0.0926
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.1663 0.533
Onchocerca volvulus 0.0046 0.0058 0.0079
Entamoeba histolytica prolyl oligopeptidase family protein 0.0247 0.0665 0.2127
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Schistosoma mansoni gabp alpha 0.0147 0.0363 0.051
Mycobacterium leprae probable zinc metalloprotease 0.0092 0.0195 0.0692
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0248 0.0671 0.2511
Loa Loa (eye worm) cytochrome P450 family protein 0.0133 0.032 0.032
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0038 0.0053
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0082 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0121
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0058 0.0081
Trypanosoma brucei calpain-like protein, putative 0.074 0.2163 0.3425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.0671 0.215
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2373 0.7117 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0338 0.0943 0.1494
Echinococcus multilocularis cathepsin L cysteine protease 0.1055 0.3119 0.4382
Echinococcus granulosus centrin 2 0.0109 0.0248 0.0348
Leishmania major hypothetical protein, conserved 0.0223 0.0592 0.0938
Loa Loa (eye worm) hypothetical protein 0.0327 0.091 0.091
Schistosoma mansoni lamin 0.0054 0.0082 0.0115
Leishmania major centrin, putative 0.0109 0.0248 0.0393
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Onchocerca volvulus 0.1055 0.3119 0.4932
Loa Loa (eye worm) cytochrome P450 0.0036 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0414 0.1174 0.1649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0121
Echinococcus granulosus neurogenic locus protein delta 0.0044 0.0051 0.0072
Trypanosoma brucei Calpain-like protein 1.2 0.0223 0.0592 0.0938
Plasmodium falciparum GPI-anchor transamidase, putative 0.0034 0.002 0.0064
Loa Loa (eye worm) calpain 5 0.0518 0.1488 0.1488
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.005 0.008
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0055 0.0083 0.0117
Mycobacterium tuberculosis Conserved protein 0.0035 0.0023 0.0004
Trichomonas vaginalis centrin, putative 0.0109 0.0248 0.0795
Leishmania major cathepsin L-like protease 0.1153 0.3415 0.5407
Plasmodium vivax calpain, putative 0.074 0.2163 0.6935
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0092 0.0195 0.0274
Onchocerca volvulus 0.0055 0.0083 0.012
Schistosoma mansoni cpg binding protein 0.0057 0.009 0.0127
Echinococcus multilocularis neurogenic locus protein delta 0.0044 0.0051 0.0072
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0223 0.0592 0.1899
Brugia malayi calpain 7 0.074 0.2163 0.2163
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0248 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.0327 0.091 0.091
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0055 0.0083 0.0083
Plasmodium vivax proteasome subunit beta type-2, putative 0.0046 0.0057 0.0183
Echinococcus multilocularis acylamino acid releasing enzyme 0.0247 0.0665 0.0935
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0038 0.0053
Leishmania major cathepsin L-like protease 0.1153 0.3415 0.5407
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.074 0.2163 0.3425
Schistosoma mansoni chromatin regulatory protein sir2 0.0132 0.0319 0.0448
Loa Loa (eye worm) hypothetical protein 0.0109 0.0248 0.0248
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0121
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0038 0.0038
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0064 0.0064
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0132 0.0319 0.1022
Brugia malayi Delta serrate ligand family protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Toxoplasma gondii prolyl endopeptidase 0.2109 0.6316 1
Onchocerca volvulus Cathepsin F homolog 0.1055 0.3119 0.4932
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Echinococcus granulosus calpain 5 0.074 0.2163 0.3039
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0026 0.0041
Schistosoma mansoni cpg binding protein 0.006 0.01 0.014
Onchocerca volvulus 0.0055 0.0083 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0251 0.0353
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0248 0.0671 0.215
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0045 0.0055 0.0055
Echinococcus multilocularis caspase 2 0.0057 0.0091 0.0127
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3425
Trypanosoma cruzi major cysteine proteinase, putative 0.0248 0.0671 0.0942
Loa Loa (eye worm) hypothetical protein 0.0096 0.0207 0.0207
Brugia malayi Eukaryotic aspartyl protease family protein 0.0055 0.0083 0.0083
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0064 0.0204
Echinococcus granulosus transmembrane protease serine 3 0.0126 0.0301 0.0423
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0248 0.0671 0.215
Echinococcus granulosus microtubule associated protein 2 0.1447 0.4307 0.6051
Echinococcus multilocularis cysteine protease 0.1055 0.3119 0.4382
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0251 0.0353
Onchocerca volvulus 0.0749 0.2191 0.3461
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0098 0.0315
Plasmodium vivax hypothetical protein, conserved 0.0247 0.0665 0.2133
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0098 0.0312
Echinococcus granulosus cathepsin L cysteine proteinase 0.1055 0.3119 0.4382
Trichomonas vaginalis calcium binding protein, putative 0.0109 0.0248 0.0795
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0083
Schistosoma mansoni hemoglobinase (C13 family) 0.0146 0.036 0.0506
Echinococcus multilocularis endothelin converting enzyme 1 0.0092 0.0195 0.0275
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Mycobacterium tuberculosis Conserved protein 0.011 0.0251 0.0416
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0026 0.0036
Brugia malayi hypothetical protein 0.0092 0.0196 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.0671 0.215
Schistosoma mansoni notch 0.0044 0.0051 0.0072
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0109 0.0248 0.0789
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0128
Onchocerca volvulus 0.0109 0.0248 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.0606 0.0851
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0251 0.0353
Mycobacterium ulcerans hypothetical protein 0.0035 0.0023 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0251 0.0926
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0248 0.0671 0.215
Loa Loa (eye worm) hypothetical protein 0.0101 0.0225 0.0225
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0044 0.0051 0.0069
Schistosoma mansoni peroxidasin 0.0502 0.1441 0.2025
Mycobacterium ulcerans zinc metalloprotease 0.0092 0.0195 0.0701
Brugia malayi Flap endonuclease-1 0.0028 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.0026 0.0022
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.0181
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0021 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.2071 0.6201 0.8713
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0109 0.0248 0.0348
Giardia lamblia Hypothetical protein 0.0248 0.0671 0.2511
Loa Loa (eye worm) hypothetical protein 0.2373 0.7117 0.7117
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.0026 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.005 0.0071
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.0301 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0728 0.2126 0.6818
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.0665 0.0935
Trypanosoma cruzi oligopeptidase b 0.0856 0.2513 0.3532
Loa Loa (eye worm) ctsf protein 0.1055 0.3119 0.3119
Giardia lamblia Hypothetical protein 0.0035 0.0023 0.0078
Brugia malayi MH2 domain containing protein 0.0244 0.0658 0.0658
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0248 0.0795
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0207 0.0328
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1862 0.5568 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0338 0.0943 0.1325
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0021 0.0066
Trypanosoma brucei protein I/6 0.0109 0.0248 0.0393
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Echinococcus granulosus cathepsin L 0.0248 0.0671 0.0942
Loa Loa (eye worm) hypothetical protein 0.006 0.0098 0.0098
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Leishmania major centrin, putative,caltractin, putative 0.0109 0.0248 0.0393
Schistosoma mansoni cathepsin F (C01 family) 0.1055 0.3119 0.4382
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0038 0.0038
Trypanosoma cruzi centrin, putative 0.0109 0.0248 0.0348
Brugia malayi hypothetical protein 0.0055 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0126 0.0301 0.0301
Brugia malayi Proteasome A-type and B-type family protein 0.0158 0.0397 0.0397
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.005 0.0161
Onchocerca volvulus Dual oxidase homolog 0.0502 0.1441 0.2272
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.0301 0.0477
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Echinococcus multilocularis EF hand domain containing family member A2 0.011 0.0252 0.0354
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0038 0.0053
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.1055 0.3119 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.0671 0.0671
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0038 0.0053
Leishmania major i/6 autoantigen-like protein 0.0109 0.0248 0.0393
Toxoplasma gondii cathepsin B 0.0906 0.2665 0.4219
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.074 0.2163 0.3039
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.0026 0.0022
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Trypanosoma brucei Aph-1 protein, putative 0.0093 0.02 0.0316
Schistosoma mansoni calcium binding atopy-related autoantigen 0.011 0.0252 0.0354
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0301 0.0423
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0146 0.0361 0.1159
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0126 0.0301 0.0423
Giardia lamblia Cathepsin L precursor 0.0248 0.0671 0.2511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0207 0.0291
Brugia malayi transcriptional regulator, Sir2 family protein 0.0132 0.0319 0.0319
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0021 0.0066
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.0026 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0247 0.0665 0.0935
Loa Loa (eye worm) hypothetical protein 0.0728 0.2126 0.2126
Brugia malayi EF hand family protein 0.0109 0.0248 0.0248
Echinococcus multilocularis cathepsin b 0.2373 0.7117 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Schistosoma mansoni hypothetical protein 0.01 0.0221 0.0311
Loa Loa (eye worm) hypothetical protein 0.1962 0.5871 0.5871
Onchocerca volvulus Cathepsin L homolog 0.1055 0.3119 0.4932
Trichomonas vaginalis calpain, putative 0.0223 0.0592 0.1899
Brugia malayi Trypsin family protein 0.0126 0.0301 0.0301
Schistosoma mansoni chromatin regulatory protein sir2 0.0132 0.0319 0.0448
Schistosoma mansoni caspase-7 (C14 family) 0.0102 0.0227 0.0318
Echinococcus granulosus endothelin converting enzyme 1 0.0092 0.0195 0.0275
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Schistosoma mansoni calpain-7 (C02 family) 0.0743 0.2173 0.3053
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.0091 0.0127
Echinococcus granulosus protein jagged 2 0.0044 0.0051 0.0072
Echinococcus multilocularis neurogenic locus notch protein 0.0044 0.0051 0.0072
Echinococcus granulosus proteasome prosome macropain 0.0158 0.0397 0.0557
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0158 0.0397 0.0557
Entamoeba histolytica cysteine protease, putative 0.0248 0.0671 0.2145
Loa Loa (eye worm) hypothetical protein 0.0126 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0126 0.0301 0.0423
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0002 0.0007
Giardia lamblia Cathepsin B precursor 0.0906 0.2665 1
Echinococcus granulosus geminin 0.0165 0.0416 0.0585
Echinococcus granulosus chromatin regulatory protein sir2 0.0132 0.0319 0.0448
Loa Loa (eye worm) sirtuin 4 0.0034 0.0021 0.0021
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0055 0.0083 0.0132
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0158 0.0397 0.0557
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0906 0.2665 0.4219
Brugia malayi Cathepsin L-like precursor 0.0327 0.091 0.091
Trypanosoma brucei antigen, putative 0.074 0.2163 0.3425
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0058 0.0081
Giardia lamblia Proteasome subunit beta type 2 0.0046 0.0057 0.0206
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0071 0.0132 0.0186
Entamoeba histolytica hypothetical protein, conserved 0.0247 0.0665 0.2127
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0108 0.0152
Trypanosoma brucei Calpain-like protein 2 0.0223 0.0592 0.0938
Brugia malayi calpain family protein 1 0.1962 0.5871 0.5871
Leishmania major protein kinase, putative 0.0109 0.0248 0.0393
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0098 0.0155
Echinococcus granulosus cathepsin b 0.2373 0.7117 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0248 0.0671 0.0942
Onchocerca volvulus 0.0092 0.0195 0.0297
Brugia malayi mbt repeat family protein 0.0046 0.0058 0.0058
Schistosoma mansoni ran 0.0044 0.005 0.0071
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0856 0.2513 1
Brugia malayi Trypsin-like protease protein 5 0.0126 0.0301 0.0301
Echinococcus granulosus neurogenic locus notch protein 0.0044 0.0051 0.0072
Echinococcus multilocularis slit 2 protein 0.0044 0.0051 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.0026 0.0022
Brugia malayi prolyl oligopeptidase family protein 0.0338 0.0943 0.0943
Entamoeba histolytica calcium binding family protein 0.0109 0.0248 0.0789
Loa Loa (eye worm) hypothetical protein 0.174 0.5195 0.5195
Echinococcus multilocularis Transglutaminase 0.0035 0.0023 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.0026 0.001
Giardia lamblia Alanyl dipeptidyl peptidase 0.0247 0.0665 0.2491
Trypanosoma cruzi cysteine peptidase, putative 0.0327 0.091 0.1278
Echinococcus multilocularis cathepsin b 0.2373 0.7117 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0223 0.0592 0.1899
Leishmania major proteasome beta 2 subunit, putative 0.0046 0.0057 0.009
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0018 0.0018
Schistosoma mansoni notch 0.0044 0.0051 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.0671 0.215
Echinococcus granulosus calbindin 32 0.011 0.0252 0.0354
Brugia malayi prolyl oligopeptidase family protein 0.0247 0.0665 0.0665
Plasmodium falciparum serine repeat antigen 1 0.0248 0.0671 0.215
Echinococcus multilocularis caspase 3 0.0075 0.0144 0.0202
Echinococcus multilocularis calbindin 32 0.011 0.0252 0.0354
Brugia malayi CXXC zinc finger family protein 0.0057 0.009 0.009
Trichomonas vaginalis centrin, putative 0.0109 0.0248 0.0795
Brugia malayi EF hand family protein 0.011 0.0252 0.0252
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0058 0.0079
Brugia malayi Calcium binding EGF domain containing protein 0.0044 0.0051 0.0051
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.0592 0.0832
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.0026 0.001
Plasmodium falciparum serine repeat antigen 3 0.0248 0.0671 0.215
Trypanosoma cruzi calmodulin, putative 0.0109 0.0248 0.0348
Trypanosoma cruzi I/6 autoantigen, putative 0.0109 0.0248 0.0348
Plasmodium vivax proteasome subunit beta type-5, putative 0.0158 0.0397 0.1272
Loa Loa (eye worm) hypothetical protein 0.0126 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0128
Entamoeba histolytica cysteine proteinase 2 0.0576 0.1663 0.533
Brugia malayi beta-lactamase family protein 0.011 0.0251 0.0251
Brugia malayi cathepsin L-like precursor 0.0728 0.2126 0.2126
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0021 0.0059
Brugia malayi Animal haem peroxidase family protein 0.0502 0.1441 0.1441
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0034 0.002 0.0064
Schistosoma mansoni calpain C (C02 family) 0.074 0.2163 0.3039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.1663 0.5333
Toxoplasma gondii peptidase family M13 protein 0.0092 0.0195 0.0309
Echinococcus granulosus neurogenic locus notch protein 4 0.0044 0.0051 0.0072
Trypanosoma cruzi calpain cysteine peptidase, putative 0.074 0.2163 0.3039
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Schistosoma mansoni cathepsin F (C01 family) 0.0728 0.2126 0.2988
Onchocerca volvulus 0.011 0.0251 0.0386
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0248 0.0671 0.0942
Loa Loa (eye worm) transcriptional regulator 0.0132 0.0319 0.0319
Brugia malayi hypothetical protein 0.0157 0.0393 0.0393
Echinococcus granulosus delta-like protein 1 0.0044 0.0051 0.0072
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0223 0.0592 0.0938
Echinococcus multilocularis inhibitor of apoptosis protein 0.0092 0.0195 0.0274
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0146 0.0361 0.1159
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0046 0.0057 0.0183
Brugia malayi Cytochrome P450 family protein 0.0133 0.032 0.032
Onchocerca volvulus 0.0109 0.0248 0.0381
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0053
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0044 0.0051 0.0072
Brugia malayi mbt repeat family protein 0.0046 0.0058 0.0058
Schistosoma mansoni calmodulin 0.0109 0.0248 0.0348
Leishmania major proteasome beta 5 subunit, putative 0.0158 0.0397 0.0628
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0002 0.0003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0058 0.0081
Echinococcus multilocularis neuronal calcium sensor 0.0109 0.0248 0.0348
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3425
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0132 0.0319 0.0448
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0636 0.1845 0.1845
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0058 0.0081
Echinococcus multilocularis cathepsin L cysteine protease 0.1055 0.3119 0.4382
Schistosoma mansoni neuronal calcium sensor 0.0109 0.0248 0.0348
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.0128 0.0128
Plasmodium vivax hypothetical protein, conserved 0.011 0.0251 0.0806
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0251 0.0926
Loa Loa (eye worm) hypothetical protein 0.011 0.0251 0.0251
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.0026 0.001
Giardia lamblia Cathepsin B precursor 0.0248 0.0671 0.2511
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0195 0.0275
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0109 0.0248 0.0795
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.005 0.0071
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Giardia lamblia Cathepsin B precursor 0.0906 0.2665 1
Brugia malayi prolyl oligopeptidase family protein 0.0247 0.0665 0.0665
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0071 0.0132 0.0186
Echinococcus multilocularis peroxidasin 0.0502 0.1441 0.2025
Brugia malayi Cytochrome P450 family protein 0.0063 0.0108 0.0108
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0098 0.0309
Trichomonas vaginalis set domain proteins, putative 0.0749 0.219 0.7023
Echinococcus multilocularis caspase 0.0102 0.0227 0.0318
Schistosoma mansoni importin beta-1 0.006 0.0098 0.0138
Leishmania major calmodulin, putative 0.0109 0.0248 0.0393
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Loa Loa (eye worm) hypothetical protein 0.0126 0.0298 0.0298
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.2109 0.6316 0.8874
Echinococcus granulosus EF hand domain containing family member A2 0.011 0.0252 0.0354
Plasmodium falciparum plasmepsin I 0.0055 0.0083 0.0267
Brugia malayi calcium-binding protein 0.0109 0.0248 0.0248
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0021 0.0029
Echinococcus multilocularis GA binding protein alpha chain 0.0147 0.0363 0.051
Leishmania major calmodulin-like protein 0.0109 0.0248 0.0393
Brugia malayi Muscle positioning protein 4 0.0044 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0048 0.0064 0.0198
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0223 0.0592 0.0938
Schistosoma mansoni notch 0.0044 0.0051 0.0072
Toxoplasma gondii hypothetical protein 0.0223 0.0592 0.0938
Echinococcus multilocularis neurocalcin 0.0109 0.0248 0.0348
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0575 0.1662 0.2335
Brugia malayi Thioredoxin family protein 0.0035 0.0023 0.0023
Leishmania major silent information regulator 2, putative 0.0132 0.0319 0.0505
Echinococcus multilocularis fat cadherin tumor suppressor 0.0044 0.0051 0.0072
Schistosoma mansoni rab 0.0109 0.0248 0.0348
Toxoplasma gondii calmodulin CAM1 0.011 0.0252 0.0399
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0109 0.0248 0.0348
Trypanosoma cruzi cysteine proteinase, putative 0.0576 0.1663 0.2337
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.0026 0.001
Loa Loa (eye worm) hypothetical protein 0.1445 0.43 0.43
Onchocerca volvulus Prolyl endopeptidase homolog 0.2109 0.6316 1
Loa Loa (eye worm) transcriptional regulator 0.0034 0.0021 0.0021
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0338 0.0943 0.1494
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0109 0.0248 0.0348
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3039
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.0592 0.1899
Echinococcus granulosus GA binding protein alpha chain 0.0147 0.0363 0.051
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.0026 0.001
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0098 0.0098
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0046 0.0057 0.008
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0002 0.0007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0005 0.0005
Onchocerca volvulus Putative cubilin 0.0044 0.0051 0.0069
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Plasmodium falciparum plasmepsin IV 0.0055 0.0083 0.0267
Schistosoma mansoni centrin 0.0109 0.0248 0.0348
Trypanosoma brucei oligopeptidase b 0.0856 0.2513 0.398
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.005
Toxoplasma gondii cathepsin CPL 0.1055 0.3119 0.4939
Echinococcus granulosus Transglutaminase 0.0035 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0146 0.0361 0.0361
Giardia lamblia Sirtuin type 2 0.0034 0.0021 0.0069
Trypanosoma brucei SIR2-like protein 4, putative 0.0034 0.0021 0.0032
Schistosoma mansoni ets-related 0.0446 0.127 0.1784
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Echinococcus granulosus cysteine protease 0.0576 0.1663 0.2337
Loa Loa (eye worm) hypothetical protein 0.0248 0.0671 0.0671
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0021 0.0066
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0055 0.0083 0.0117
Onchocerca volvulus 0.0054 0.0082 0.0117
Loa Loa (eye worm) MBCTL1 0.0053 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Echinococcus multilocularis neurogenic locus protein delta 0.0044 0.0051 0.0072
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0576 0.1663 0.2337
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0247 0.0665 0.1053
Giardia lamblia Cathepsin L-like protease 0.0248 0.0671 0.2511
Echinococcus granulosus dnaJ subfamily B 0.0414 0.1174 0.1649
Brugia malayi Blistered cuticle protein 3 0.0502 0.1441 0.1441
Leishmania major hypothetical protein, unknown function 0.0223 0.0592 0.0938
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0034 0.0021 0.0029
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0071 0.0132 0.021
Schistosoma mansoni hypothetical protein 0.0044 0.0051 0.0072
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0248 0.0671 0.215
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0055 0.0083 0.0083
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.0026 0.0022
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0026 0.0012
Trypanosoma brucei calpain-like protein, putative 0.074 0.2163 0.3425
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0251 0.0416
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0383 0.1078 0.1515
Entamoeba histolytica hypothetical protein 0.0248 0.0671 0.2145
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.0671 0.0942
Loa Loa (eye worm) hypothetical protein 0.0248 0.0671 0.0671
Onchocerca volvulus Cathepsin L homolog 0.1055 0.3119 0.4932
Loa Loa (eye worm) hypothetical protein 0.0053 0.0079 0.0079
Schistosoma mansoni mitochondrial solute carrier 0.0109 0.0248 0.0348
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.0026 0.0022
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Echinococcus multilocularis cysteine protease 0.1055 0.3119 0.4382
Brugia malayi Cathepsin L-like precursor 0.0728 0.2126 0.2126
Schistosoma mansoni neuronal calcium sensor 0.0109 0.0248 0.0348
Onchocerca volvulus 0.0157 0.0393 0.061
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0098 0.0138
Loa Loa (eye worm) calpain family protein 1 0.1445 0.43 0.43
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0251 0.0416
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Brugia malayi cathepsin Z-like cysteine proteinase 0.0248 0.0671 0.0671
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Loa Loa (eye worm) hypothetical protein 0.0092 0.0195 0.0195
Echinococcus multilocularis microtubule associated protein 2 0.1447 0.4307 0.6051
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0053
Plasmodium vivax serine-repeat antigen (SERA) 0.0248 0.0671 0.215
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0034 0.0021 0.0029
Leishmania major calmodulin-like protein 0.0109 0.0248 0.0393
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3039
Plasmodium vivax GPI-anchor transamidase, putative 0.0034 0.002 0.0064
Echinococcus multilocularis centrin 2 0.0109 0.0248 0.0348
Echinococcus granulosus snurportin 1 0.0636 0.1845 0.2593
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0038 0.0053
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Schistosoma mansoni reticulocalbin 0.0109 0.0248 0.0348
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0002 0.0003
Schistosoma mansoni ef hand domain family member A2 0.0109 0.0248 0.0348
Brugia malayi NAD-dependent deacetylase SIRT1 0.0146 0.0361 0.0361
Schistosoma mansoni chromatin regulatory protein sir2 0.0132 0.0319 0.0448
Giardia lamblia Hypothetical protein 0.011 0.0252 0.094
Giardia lamblia Proteasome subunit beta type 1 0.0071 0.0132 0.0489
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Schistosoma mansoni calpain (C02 family) 0.074 0.2163 0.3039
Brugia malayi prolyl oligopeptidase family protein 0.2109 0.6316 0.6316
Entamoeba histolytica cysteine proteinase, putative 0.0728 0.2126 0.6816
Brugia malayi Cathepsin L-like precursor 0.0728 0.2126 0.2126
Echinococcus granulosus calpain A 0.2073 0.6206 0.8719
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.0026 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0023 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0064 0.0204
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0038 0.0053
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0247 0.0665 0.2127
Giardia lamblia Cathepsin L precursor 0.0248 0.0671 0.2511
Plasmodium vivax aspartyl protease, putative 0.0318 0.0881 0.2824
Onchocerca volvulus 0.0044 0.0051 0.0069
Brugia malayi Cell death protein 3 precursor 0.0057 0.0091 0.0091
Schistosoma mansoni notch 0.0044 0.0051 0.0072
Echinococcus granulosus protein jagged 2 0.0044 0.0051 0.0072
Toxoplasma gondii histone deacetylase SIR2-like 0.0034 0.0021 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0098 0.0155
Echinococcus multilocularis expressed protein 0.0774 0.2266 0.3183
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0338 0.0943 0.1325
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1652 0.4929 0.6925
Leishmania major cathepsin L-like protease 0.1055 0.3119 0.4939
Toxoplasma gondii hypothetical protein 0.0247 0.0665 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0092 0.0195 0.0195
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.0026 0.0022
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0146 0.0361 0.1159
Plasmodium vivax unspecified product 0.0248 0.0671 0.215
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0383 0.1078 0.1515
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0132 0.0319 0.1016
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0248 0.0671 0.215
Entamoeba histolytica cysteine proteinase, putative 0.1055 0.3119 1
Schistosoma mansoni hypothetical protein 0.0223 0.0592 0.0832
Onchocerca volvulus 0.011 0.0251 0.0386
Brugia malayi hypothetical protein 0.0491 0.1406 0.1406
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0055 0.0083 0.0267
Echinococcus multilocularis hypothetical protein 0.074 0.2163 0.3039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Schistosoma mansoni axis inhibition protein axin 0.004 0.0038 0.0053
Echinococcus multilocularis glycoprotein Antigen 5 0.0126 0.0301 0.0423
Trypanosoma brucei prolyl oligopeptidase, putative 0.0856 0.2513 0.398
Echinococcus granulosus enteropeptidase 0.0126 0.0301 0.0423
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0098 0.5
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0034 0.0021 0.0029
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.0592 0.0832
Mycobacterium tuberculosis Conserved protein 0.011 0.0251 0.0416
Brugia malayi Calmodulin-like protein 0.0109 0.0248 0.0248
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.005
Giardia lamblia Hypothetical protein 0.0132 0.0319 0.1189
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0251 0.0251
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.02 0.0281
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Echinococcus granulosus notch 0.0044 0.0051 0.0072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0248 0.0671 0.0671
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0146 0.0361 0.0508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.0606 0.0851
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0038 0.0053
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0248 0.0671 0.215
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.011 0.0252 0.0354
Schistosoma mansoni cytochrome P450 0.0036 0.0026 0.0036
Brugia malayi hypothetical protein 0.003 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0248 0.0671 0.2145
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.0026 0.001
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Trypanosoma cruzi cysteine peptidase, putative 0.1055 0.3119 0.4382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0248 0.0671 0.215
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0092 0.0195 0.0274
Echinococcus granulosus protein jagged 1 0.0044 0.0051 0.0072
Echinococcus granulosus programmed cell death protein 0.0109 0.0248 0.0348
Schistosoma mansoni cell polarity protein 0.0044 0.0051 0.0072
Plasmodium falciparum plasmepsin III 0.0055 0.0083 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0665 0.2133
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Toxoplasma gondii EF hand domain-containing protein 0.0109 0.0248 0.0393
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0082 0.0082
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0248 0.0671 0.215
Entamoeba histolytica cysteine protease, putative 0.0248 0.0671 0.2145
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Brugia malayi Cadherin domain containing protein 0.0044 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.011 0.0251 0.0398
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0146 0.0361 0.1159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0248 0.0671 0.0671
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1055 0.3119 0.3119
Trypanosoma brucei Component of motile flagella 41 0.0109 0.0248 0.0393
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0053
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0044 0.0051 0.0051
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0077 0.0109
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2373 0.7117 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0046 0.0057 0.0176
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0077 0.0109
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Brugia malayi Pre-SET motif family protein 0.0658 0.1915 0.1915
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0109 0.0248 0.0348
Onchocerca volvulus 0.0044 0.0051 0.0069
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0126 0.0301 0.0301
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0223 0.0592 0.0832
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.0606 0.0851
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1055 0.3119 0.4382
Schistosoma mansoni gamma-secretase subunit aph-1 0.0239 0.0642 0.0902
Echinococcus multilocularis calpain family protein 1, d 0.1445 0.43 0.6042
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0248 0.0671 0.215
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0146 0.0361 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Plasmodium vivax vivapain-1 0.0576 0.1663 0.5333
Echinococcus granulosus neurogenic locus notch protein 0.0044 0.0051 0.0072
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0147 0.0363 0.0363
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0034 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0294 0.0808 0.1135
Toxoplasma gondii exonuclease III APE 0.006 0.0098 0.0156
Brugia malayi Fli-1 protein 0.0446 0.127 0.127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0023 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0098 0.014
Trichomonas vaginalis calmodulin, putative 0.011 0.0252 0.0809
Plasmodium falciparum plasmepsin VIII, putative 0.0055 0.0083 0.0267
Trypanosoma brucei hypothetical protein 0.0223 0.0592 0.0938
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Schistosoma mansoni survival motor neuron protein 0.01 0.0221 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.0671 0.215
Onchocerca volvulus Cathepsin L homolog 0.0248 0.0671 0.1051
Loa Loa (eye worm) cathepsin B 0.0906 0.2665 0.2665
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0071 0.0132 0.0186
Schistosoma mansoni Mername-AA248 (C02 family) 0.074 0.2163 0.3039
Echinococcus granulosus acylamino acid releasing enzyme 0.0247 0.0665 0.0935
Mycobacterium ulcerans hypothetical protein 0.011 0.0251 0.0926
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.0051 0.0051
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0038 0.0053
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.2109 0.6316 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0064 0.0064
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0058 0.0081
Loa Loa (eye worm) hypothetical protein 0.011 0.0251 0.0251
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0132 0.0319 0.0448
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0034 0.002 0.0032
Echinococcus multilocularis tumor protein p63 0.0692 0.2018 0.2835
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Plasmodium vivax importin-beta 2, putative 0.006 0.0098 0.0314
Brugia malayi Importin beta-1 subunit 0.006 0.0098 0.0098
Trypanosoma cruzi caltractin, putative 0.0109 0.0248 0.0348
Onchocerca volvulus 0.0044 0.0051 0.0069
Brugia malayi Peroxidasin 0.0502 0.1441 0.1441
Trichomonas vaginalis peptide N-glycanase, putative 0.0035 0.0023 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 0.3415 0.5407
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0109 0.0248 0.0348
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0132 0.0319 0.0505
Brugia malayi Animal haem peroxidase family protein 0.0502 0.1441 0.1441
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0132 0.0319 0.0448
Leishmania major cathepsin L-like protease 0.1153 0.3415 0.5407
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0109 0.0248 0.0795
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0338 0.0943 0.1325
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0223 0.0592 0.0832
Echinococcus multilocularis calcium uptake protein 1 0.011 0.0252 0.0354
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0223 0.0592 0.1899
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0248 0.0671 0.215
Onchocerca volvulus Peroxidasin homolog 0.0502 0.1441 0.2272
Trypanosoma cruzi conserved protein 0.0223 0.0592 0.0832
Echinococcus multilocularis cathepsin L 0.0576 0.1663 0.2337
Echinococcus multilocularis importin subunit beta 1 0.006 0.0098 0.0138
Schistosoma mansoni microtubule-associated protein tau 0.1447 0.4307 0.6051
Onchocerca volvulus 0.011 0.0251 0.0386
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0038 0.0053
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2071 0.6201 0.8713
Brugia malayi Peptidase family M13 containing protein 0.0092 0.0195 0.0195
Schistosoma mansoni calmodulin 0.0109 0.0248 0.0348
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0098 0.0138
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0576 0.1663 0.2337
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0239 0.0642 0.0642
Onchocerca volvulus 0.0126 0.0301 0.0465
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0251 0.0806
Trypanosoma brucei Calpain-like protein CALP1.3 0.0223 0.0592 0.0938
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0146 0.036 0.1155
Brugia malayi RNA, U transporter 1 0.0169 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0491 0.1406 0.1406
Leishmania major cytochrome p450-like protein 0.0036 0.0026 0.0041
Loa Loa (eye worm) beta-lactamase 0.011 0.0251 0.0251
Trypanosoma cruzi calmodulin, putative 0.0109 0.0248 0.0348
Loa Loa (eye worm) hypothetical protein 0.0057 0.0091 0.0091
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0704 0.2052 0.3662
Echinococcus granulosus protein jagged 1 0.0044 0.0051 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.0671 0.215
Loa Loa (eye worm) hypothetical protein 0.0327 0.091 0.091
Loa Loa (eye worm) cysteine protease 0.1055 0.3119 0.3119
Onchocerca volvulus 0.0502 0.1441 0.2272
Leishmania major phospholipase c-like protein 0.0109 0.0248 0.0393
Plasmodium falciparum centrin-1 0.0109 0.0248 0.0795
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0096 0.0207 0.0291
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0158 0.0397 0.0678
Brugia malayi Trypsin family protein 0.0126 0.0301 0.0301
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0034 0.0021 0.0032
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0005 0.0005
Onchocerca volvulus 0.0045 0.0055 0.0075
Schistosoma mansoni calpain-2 (C02 family) 0.0223 0.0592 0.0832
Schistosoma mansoni septate junction protein 0.0044 0.0051 0.0072
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.0301 0.0506
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.074 0.2163 0.3425
Echinococcus granulosus cathepsin l1 0.1055 0.3119 0.4382
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Loa Loa (eye worm) hypothetical protein 0.0223 0.0592 0.0592
Mycobacterium tuberculosis Hypothetical protein 0.0035 0.0023 0.0004
Trichomonas vaginalis hypothetical protein 0.0223 0.0592 0.1899
Loa Loa (eye worm) notch protein 0.0044 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0728 0.2126 0.6818
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0034 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0077 0.0077
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.0026 0.0022
Entamoeba histolytica hypothetical protein, conserved 0.011 0.0252 0.0803
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0046 0.0057 0.009
Brugia malayi Ets-domain containing protein 0.0147 0.0363 0.0363
Mycobacterium tuberculosis Conserved protein 0.011 0.0251 0.0416
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0146 0.036 0.1155
Schistosoma mansoni hypothetical protein 0.0044 0.0051 0.0072
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0158 0.0397 0.1501
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0146 0.036 0.1155
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Brugia malayi cytochrome P450 0.0036 0.0026 0.0026
Plasmodium falciparum serine repeat antigen 5 0.0248 0.0671 0.215
Trypanosoma cruzi 20S proteasome subunit 0.0046 0.0057 0.008
Echinococcus multilocularis enteropeptidase 0.0126 0.0301 0.0423
Brugia malayi Animal haem peroxidase family protein 0.0502 0.1441 0.1441
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0034 0.0021 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1055 0.3119 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0123 0.0123
Mycobacterium leprae conserved hypothetical protein 0.011 0.0251 0.0917
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0856 0.2513 0.398
Schistosoma mansoni cpg binding protein 0.006 0.01 0.014
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0034 0.0021 0.0059
Giardia lamblia Cysteine protease 0.0248 0.0671 0.2511
Echinococcus multilocularis neural cadherin 0.0044 0.0051 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0251 0.0353
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1055 0.3119 1
Loa Loa (eye worm) hypothetical protein 0.0502 0.1441 0.1441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Brugia malayi calpain 5 0.0223 0.0592 0.0592
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Loa Loa (eye worm) programmed cell death protein 6 0.011 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Onchocerca volvulus 0.1222 0.3625 0.5734
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0146 0.036 0.1155
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0248 0.0393
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0126 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0034 0.002 0.002
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0126 0.0301 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0121
Onchocerca volvulus Deterin homolog 0.0092 0.0195 0.0297
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.0592 0.0832
Entamoeba histolytica calmodulin, putative 0.0109 0.0248 0.0789
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0077 0.0077
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.005 0.0071
Echinococcus granulosus intermediate filament protein 0.0054 0.0082 0.0115
Brugia malayi EGF-like domain containing protein 0.0044 0.0051 0.0051
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0338 0.0943 0.1494
Onchocerca volvulus 0.0728 0.2126 0.3359
Leishmania major cysteine peptidase A (CPA) 0.1055 0.3119 0.4939
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0109 0.0248 0.0795
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0038 0.0053
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0223 0.0592 0.1899
Schistosoma mansoni hypothetical protein 0.0044 0.0051 0.0072
Mycobacterium ulcerans hypothetical protein 0.0035 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.1055 0.3119 0.3119
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0158 0.0397 0.0557
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.074 0.2163 0.3039
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Brugia malayi aspartic protease BmAsp-2, identical 0.0055 0.0083 0.0083
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0248 0.0671 0.2511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0034 0.0021 0.0066
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.0301 0.0423
Schistosoma mansoni cathepsin D (A01 family) 0.0361 0.1014 0.1425
Trypanosoma cruzi cysteine peptidase, putative 0.1153 0.3415 0.4798
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0207 0.0291
Echinococcus granulosus cathepsin L cysteine protease 0.0576 0.1663 0.2337
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0207 0.0291
Onchocerca volvulus 0.0248 0.0671 0.1051
Mycobacterium ulcerans proteasome PrcB 0.0158 0.0397 0.1509
Schistosoma mansoni ap endonuclease 0.006 0.0098 0.0138
Toxoplasma gondii preprocathepsin c precursor, putative 0.0248 0.0671 0.1062
Toxoplasma gondii troponin c, isotype gamma, putative 0.0109 0.0248 0.0393
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0507 0.0713
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.0026 0.001
Plasmodium vivax NAD-dependent deacetylase, putative 0.0034 0.0021 0.0066
Loa Loa (eye worm) animal heme peroxidase 0.0502 0.1441 0.1441
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Mycobacterium leprae putative cytochrome p450 0.0036 0.0026 0.0012
Schistosoma mansoni neuronal calcium sensor 0.0109 0.0248 0.0348
Schistosoma mansoni calpain-7 (C02 family) 0.0743 0.2173 0.3053
Echinococcus granulosus inhibitor of apoptosis protein 0.0092 0.0195 0.0274
Echinococcus multilocularis musashi 0.0054 0.0082 0.0115
Loa Loa (eye worm) RGS-3 protein 0.004 0.0038 0.0038
Giardia lamblia Hypothetical protein 0.0248 0.0671 0.2511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0251 0.0806
Loa Loa (eye worm) animal heme peroxidase 0.0502 0.1441 0.1441
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0046 0.0057 0.008
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0832
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0098 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Schistosoma mansoni intermediate filament proteins 0.0054 0.0082 0.0115
Loa Loa (eye worm) hypothetical protein 0.0247 0.0665 0.0665
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0053
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0038 0.0038
Leishmania major cathepsin L-like protease 0.1055 0.3119 0.4939
Onchocerca volvulus 0.0101 0.0225 0.0344
Trypanosoma brucei proteasome beta 6 subunit 0.0071 0.0132 0.021
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.0026 0.001
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0046 0.0057 0.008
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Brugia malayi beta-lactamase 0.011 0.0251 0.0251
Echinococcus granulosus cathepsin L 0.0576 0.1663 0.2337
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0038 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0248 0.0671 0.215
Brugia malayi Papain family cysteine protease containing protein 0.0248 0.0671 0.0671
Schistosoma mansoni hypothetical protein 0.0636 0.1845 0.2593
Brugia malayi fibroinase precursor 0.0248 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.0126 0.0301 0.0301
Plasmodium falciparum peptidase, putative 0.0247 0.0665 0.2133
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.0671 0.215
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0327 0.091 0.091
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0092 0.0195 0.0195
Brugia malayi prolyl oligopeptidase family protein 0.0575 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Brugia malayi PXA domain containing protein 0.004 0.0038 0.0038
Trichomonas vaginalis calmodulin, putative 0.0109 0.0248 0.0795
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0002 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.0491 0.1406 0.1976
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0092 0.0195 0.0195
Toxoplasma gondii cathepsin CPC2 0.0248 0.0671 0.1062
Echinococcus granulosus peroxidasin 0.0502 0.1441 0.2025
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0083
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0248 0.0671 0.2511
Brugia malayi hypothetical protein 0.0127 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.003 0.0008 0.0011
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0248 0.0671 0.215
Schistosoma mansoni cathepsin F (C01 family) 0.1055 0.3119 0.4382
Trypanosoma cruzi centrin-3 0.0109 0.0248 0.0348
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Giardia lamblia Cathepsin B precursor 0.0906 0.2665 1
Trypanosoma cruzi cruzipain precursor, putative 0.0327 0.091 0.1278
Plasmodium vivax plasmepsin V, putative 0.0055 0.0083 0.0267
Entamoeba histolytica calpain large subunit domain III containing protein 0.0518 0.1488 0.4767
Brugia malayi EGF-like domain containing protein 0.0044 0.0051 0.0051
Leishmania major centrin, putative 0.0109 0.0248 0.0393
Brugia malayi aspartic protease BmAsp-1, identical 0.0055 0.0083 0.0083
Plasmodium falciparum plasmepsin X 0.0318 0.0881 0.2824
Plasmodium falciparum serine repeat antigen 7 0.0248 0.0671 0.215
Loa Loa (eye worm) hypothetical protein 0.0092 0.0196 0.0196
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0223 0.0592 0.0938
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0251 0.0416
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.2109 0.6316 0.8874
Loa Loa (eye worm) hypothetical protein 0.0248 0.0671 0.0671
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0058 0.0081
Loa Loa (eye worm) calpain 0.074 0.2163 0.2163
Onchocerca volvulus 0.0126 0.0301 0.0465
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0053
Loa Loa (eye worm) hypothetical protein 0.0068 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0098 0.0156
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0026 0.0041
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0248 0.0671 0.0671
Brugia malayi Cathepsin L-like precursor 0.1055 0.3119 0.3119
Schistosoma mansoni hypothetical protein 0.0036 0.0026 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.0671 0.215
Trypanosoma brucei calpain-like protein, putative 0.074 0.2163 0.3425
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0038 0.0053
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0223 0.0592 0.0832
Trypanosoma brucei prolyl endopeptidase 0.2109 0.6316 1
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0247 0.0665 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0248 0.0671 0.215
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0098 0.0098
Echinococcus granulosus caspase 3 0.0075 0.0144 0.0202
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0301 0.0423
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0098 0.0156
Onchocerca volvulus Neurogenic locus notch homolog 0.0044 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.0109 0.0248 0.0248
Brugia malayi Trypsin family protein 0.0126 0.0301 0.0301
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2071 0.6201 0.8713
Trypanosoma brucei calmodulin, putative 0.011 0.0252 0.0399
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.005 0.0071
Onchocerca volvulus Legumain homolog 0.0146 0.036 0.0559
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0034 0.0021 0.0059
Schistosoma mansoni notch 0.0044 0.0052 0.0073
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Entamoeba histolytica prolyl oligopeptidase family protein 0.0247 0.0665 0.2127
Plasmodium vivax aspartyl protease, putative 0.0055 0.0083 0.0267
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0098 0.0361
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0034 0.002 0.0032
Leishmania major oligopeptidase b 0.0856 0.2513 0.398
Brugia malayi transcriptional regulator, Sir2 family protein 0.0034 0.0021 0.0021
Loa Loa (eye worm) fli-1 protein 0.0446 0.127 0.127
Onchocerca volvulus 0.1055 0.3119 0.4932
Leishmania major cytochrome p450-like protein 0.0036 0.0026 0.0041
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0038 0.0053
Onchocerca volvulus 0.0126 0.0301 0.0465
Plasmodium falciparum plasmepsin V 0.0055 0.0083 0.0267
Brugia malayi calpain family protein 1 0.1962 0.5871 0.5871
Entamoeba histolytica hypothetical protein 0.004 0.0038 0.0115
Brugia malayi Cytochrome P450 family protein 0.0063 0.0108 0.0108
Giardia lamblia Alanyl dipeptidyl peptidase 0.0247 0.0665 0.2491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0248 0.0671 0.215
Echinococcus granulosus axis inhibition protein axin 0.004 0.0038 0.0053
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.0592 0.0832
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0728 0.2126 0.2126
Schistosoma mansoni notch 0.0044 0.0051 0.0072
Echinococcus multilocularis EF hand domain containing family member A2 0.0109 0.0248 0.0348
Plasmodium falciparum serine repeat antigen 9 0.0248 0.0671 0.215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) Notch2 0.0044 0.0051 0.0051
Echinococcus multilocularis Mastin 0.0126 0.0301 0.0423
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0108 0.0108
Giardia lamblia Cathepsin L-like protease 0.0248 0.0671 0.2511
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.0665 0.0935
Schistosoma mansoni reticulocalbin 0.011 0.0252 0.0354
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0109 0.0248 0.0393
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.0026 0.0022
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0064 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1055 0.3119 1
Brugia malayi hypothetical protein 0.0502 0.1441 0.1441
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.0026 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0126 0.0301 0.0423
Loa Loa (eye worm) prolyl oligopeptidase 0.0575 0.1662 0.1662
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.0301 0.0477
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0248 0.0671 0.215
Loa Loa (eye worm) hypothetical protein 0.0054 0.0082 0.0082
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0083 0.0117
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0092 0.0195 0.0315
Loa Loa (eye worm) animal heme peroxidase 0.0502 0.1441 0.1441
Giardia lamblia Cathepsin B precursor 0.0248 0.0671 0.2511
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1055 0.3119 0.4382
Onchocerca volvulus 0.0126 0.0301 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0248 0.0795
Toxoplasma gondii centrin, putative 0.0109 0.0248 0.0393
Toxoplasma gondii centrin 0.0109 0.0248 0.0393
Schistosoma mansoni cathepsin B (C01 family) 0.0248 0.0671 0.0942
Giardia lamblia Cathepsin L precursor 0.0248 0.0671 0.2511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0207 0.0291
Brugia malayi cathepsin F-like cysteine proteinase 0.0248 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Leishmania major GTP-binding protein, putative 0.0044 0.005 0.008
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.0026 0.0022
Echinococcus multilocularis lamin dm0 0.0054 0.0082 0.0115
Leishmania major programmed cell death 6 protein-like protein 0.0109 0.0248 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.0671 0.215
Trichomonas vaginalis calcium binding protein, putative 0.0109 0.0248 0.0795
Mycobacterium tuberculosis Long conserved protein 0.0035 0.0023 0.0004
Trypanosoma brucei Calpain-like protein 1.1 0.0223 0.0592 0.0938
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.0026 0.001
Loa Loa (eye worm) calmodulin-like protein 0.0109 0.0248 0.0248
Brugia malayi Ets-domain containing protein 0.0147 0.0363 0.0363
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0146 0.036 0.1155
Brugia malayi EGF-like domain containing protein 0.0044 0.0051 0.0051
Loa Loa (eye worm) CYP4Cod1 0.0063 0.0108 0.0108
Brugia malayi hypothetical protein 0.004 0.0038 0.0038
Echinococcus granulosus expressed protein 0.0774 0.2266 0.3183
Toxoplasma gondii cathepsin CPC1 0.0248 0.0671 0.1062
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0038 0.0053
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0092 0.0195 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0207 0.0291
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0108 0.0152
Giardia lamblia GPI-anchor transamidase, putative 0.0034 0.002 0.0068
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1055 0.3119 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.0671 0.0942
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0046 0.0057 0.0183
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0071 0.0132 0.0186
Entamoeba histolytica cysteine proteinase 1, putative 0.0576 0.1663 0.533
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0038 0.0038
Entamoeba histolytica cysteine protease, putative 0.0576 0.1663 0.533
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.0026 0.0022
Loa Loa (eye worm) calpain family protein 1 0.1962 0.5871 0.5871
Plasmodium vivax aspartyl proteinase, putative 0.0055 0.0083 0.0267
Echinococcus multilocularis snurportin 1 0.0636 0.1845 0.2593
Schistosoma mansoni chromatin regulatory protein sir2 0.0146 0.0361 0.0508
Entamoeba histolytica grainin 2 0.0109 0.0248 0.0789
Loa Loa (eye worm) hypothetical protein 0.0247 0.0665 0.0665
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0038 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0053
Schistosoma mansoni neuronal calcium sensor 0.0109 0.0248 0.0348
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0071 0.0132 0.021
Echinococcus granulosus importin subunit beta 1 0.006 0.0098 0.0138
Plasmodium falciparum cysteine proteinase falcipain 1 0.0576 0.1663 0.5333
Leishmania major cathepsin L-like protease 0.1055 0.3119 0.4939
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0575 0.1662 0.2335
Echinococcus multilocularis calpain 5 0.074 0.2163 0.3039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0193 0.0271
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0008 0.0011
Brugia malayi intermediate filament protein 0.0054 0.0082 0.0082
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0058 0.0081
Brugia malayi notch-like transmembrane receptor 0.0044 0.0051 0.0051
Plasmodium vivax aspartyl proteinase, putative 0.0055 0.0083 0.0267
Echinococcus granulosus lamin 0.0054 0.0082 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0301 0.1126
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.011 0.0251 0.0251
Echinococcus granulosus cathepsin b 0.2373 0.7117 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0008 0.0011
Echinococcus granulosus gamma secretase subunit aph 1 0.0239 0.0642 0.0902
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2373 0.7117 1
Onchocerca volvulus 0.0054 0.0082 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.0026 0.001
Entamoeba histolytica calcium-binding protein, putative 0.0109 0.0248 0.0789
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.0091 0.0131
Trypanosoma brucei kinesin, putative 0.0518 0.1488 0.2356
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.1663 0.533
Schistosoma mansoni cathepsin s 0.0327 0.091 0.1278
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0338 0.0943 0.1494
Brugia malayi Cathepsin L-like cysteine proteinase 0.0728 0.2126 0.2126
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.0671 0.215
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.0658 0.0658
Leishmania major kinesin, putative 0.0518 0.1488 0.2356
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.0026 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.0671 0.0942
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0248 0.0671 0.0942
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0038 0.0053
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Schistosoma mansoni hypothetical protein 0.0044 0.0051 0.0072
Echinococcus multilocularis protein jagged 2 0.0044 0.0051 0.0072
Onchocerca volvulus Huntingtin homolog 0.0127 0.0303 0.0468
Schistosoma mansoni ran 0.0044 0.005 0.0071
Plasmodium vivax plasmepsin IV, putative 0.0055 0.0083 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1055 0.3119 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.0026 0.0022
Loa Loa (eye worm) transcriptional regulator 0.0034 0.0021 0.0021
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0158 0.0397 0.1272
Loa Loa (eye worm) hypothetical protein 0.2109 0.6316 0.6316
Plasmodium vivax unspecified product 0.0576 0.1663 0.5333
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0053
Giardia lamblia Cathepsin L precursor 0.0248 0.0671 0.2511
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0046 0.0057 0.008
Trichomonas vaginalis calmodulin-2, putative 0.0109 0.0248 0.0795
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0098 0.0138
Echinococcus multilocularis fibropellin Ia 0.0044 0.0051 0.0072
Loa Loa (eye worm) proteasome subunit beta type 2 0.0046 0.0057 0.0057
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.0026 0.0022
Toxoplasma gondii aspartyl protease 0.0055 0.0083 0.0132
Schistosoma mansoni hypothetical protein 0.0044 0.0051 0.0072
Brugia malayi hypothetical protein 0.0126 0.0301 0.0301
Plasmodium vivax aspartyl protease, putative 0.0318 0.0881 0.2824
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0327 0.091 0.091
Plasmodium vivax centrin-1, putative 0.0109 0.0248 0.0795
Schistosoma mansoni inhibitor of apoptosis protein 0.0092 0.0195 0.0274
Entamoeba histolytica calpain family cysteine protease, putative 0.0223 0.0592 0.1894
Giardia lamblia Cathepsin L precursor 0.0248 0.0671 0.2511
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0251 0.0251
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0132 0.0319 0.0448
Trypanosoma brucei cysteine peptidase C (CPC) 0.0906 0.2665 0.4219
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.074 0.2163 0.3039
Schistosoma mansoni calmodulin related calcium binding protein 0.0109 0.0248 0.0348
Leishmania major importin beta-1 subunit, putative 0.0048 0.0064 0.0101
Brugia malayi Cathepsin L-like precursor 0.1055 0.3119 0.3119
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.0592 0.0938
Loa Loa (eye worm) hypothetical protein 0.011 0.0251 0.0251
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0055 0.0083 0.0132
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0383 0.1078 0.1515
Echinococcus multilocularis geminin 0.0165 0.0416 0.0585
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0021 0.0066
Loa Loa (eye worm) hypothetical protein 0.0127 0.0303 0.0303
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0071 0.0132 0.0425
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.0671 0.215
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.0026 0.0022
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0576 0.1663 0.2337
Toxoplasma gondii EFHC1, putative 0.0109 0.0248 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0576 0.1663 0.2634
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0077 0.0109
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0248 0.0671 0.2511
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.3323 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.0606 0.0606
Brugia malayi Cathepsin L-like precursor 0.1055 0.3119 0.3119
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0098 0.0315
Loa Loa (eye worm) hypothetical protein 0.0126 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0044 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, putative 0.0223 0.0592 0.0938
Trypanosoma cruzi kinesin, putative 0.0518 0.1488 0.2091
Brugia malayi Papain family cysteine protease containing protein 0.0248 0.0671 0.0671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0576 0.1663 0.2634
Loa Loa (eye worm) hypothetical protein 0.0728 0.2126 0.2126
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0123 0.0123
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0102 0.0227 0.0318
Onchocerca volvulus 0.0126 0.0301 0.0465
Brugia malayi Cytochrome P450 family protein 0.0036 0.0026 0.0026
Trypanosoma cruzi centrin, putative 0.0109 0.0248 0.0348
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0063 0.0108 0.0351

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100000 nM Displacement of [3H]mesulergine from 5HT2C receptor ChEMBL. 16870427
IC50 (binding) > 100000 nM Displacement of [3H]mesulergine from 5HT2C receptor ChEMBL. 16870427
Ki (binding) = 51 nM Binding affinity to MCHR1 by radioligand binding assay ChEMBL. 16870427
Ki (binding) = 51 nM Binding affinity to MCHR1 by radioligand binding assay ChEMBL. 16870427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.