Detailed information for compound 402445

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1260.9 | Formula: C40H30N12O12Pt2++++++++
  • H donors: 0 H acceptors: 12 LogP: 1.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 3
  • SMILES: c1cc[n+]2c(c1)c1cccc3[n+]1[Pt+2]2([n+]1ccc(cc1)c1cc[n+](cc1)[Pt+2]12[n+]4ccccc4c4[n+]2c(c2[n+]1cccc2)ccc4)[n+]1ccccc31.[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-]
  • InChi: 1S/2C15H11N3.C10H8N2.4NO3.2Pt/c2*1-3-10-16-12(6-1)14-8-5-9-15(18-14)13-7-2-4-11-17-13;1-5-11-6-2-9(1)10-3-7-12-8-4-10;4*2-1(3)4;;/h2*1-11H;1-8H;;;;;;/q;;;4*-1;2*+6
  • InChiKey: VHWKMKQRRSUOQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0677 0.0677
Schistosoma mansoni hypothetical protein 0.0049 0.0102 0.0102
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0576 0.332 0.332
Entamoeba histolytica cysteine proteinase 1, putative 0.0473 0.2694 0.5186
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0576 0.332 0.332
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0073 0.025 0.0482
Brugia malayi calpain 5 0.0333 0.1837 0.1837
Echinococcus multilocularis calcium uptake protein 1 0.0074 0.0257 0.0257
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0083 0.0312 0.0365
Plasmodium vivax unspecified product 0.0473 0.2694 0.5186
Echinococcus multilocularis histone deacetylase 8 0.0043 0.0064 0.0064
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0989 0.0989
Trichomonas vaginalis calpain, putative 0.0143 0.0677 0.1303
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.0553 0.0647
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0073 0.025 0.0482
Trichomonas vaginalis centrin, putative 0.0073 0.025 0.0482
Echinococcus granulosus histone deacetylase 6 0.01 0.0413 0.0413
Onchocerca volvulus 0.0603 0.349 0.3482
Loa Loa (eye worm) blistered cuticle protein 3 0.0065 0.0199 0.0199
Echinococcus multilocularis centrin 2 0.0073 0.025 0.025
Onchocerca volvulus Cathepsin L homolog 0.0882 0.5195 0.5189
Trypanosoma brucei calpain-like protein, putative 0.0476 0.2712 0.2712
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0199 0.0199
Brugia malayi Cytochrome P450 family protein 0.0033 0.0004 0.0004
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0126 0.0571 0.0571
Loa Loa (eye worm) EF hand family protein 0.0073 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Trypanosoma brucei histone deacetylase 3 0.01 0.0413 0.0413
Plasmodium vivax unspecified product 0.0194 0.0989 0.1904
Echinococcus multilocularis histone deacetylase 6 0.01 0.0413 0.0413
Trypanosoma cruzi cruzipain precursor, putative 0.0279 0.1507 0.1507
Echinococcus multilocularis Glycosyl transferase, family 35 0.0107 0.0453 0.0453
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Entamoeba histolytica glycogenphosphorylase, putative 0.0046 0.0084 0.0161
Echinococcus multilocularis peptidase Clp (S14 family) 0.0117 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.1262 0.7516 0.7516
Giardia lamblia Alanyl dipeptidyl peptidase 0.0238 0.1254 0.3754
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0205 0.0205
Trypanosoma cruzi cysteine peptidase, putative 0.098 0.5794 0.5794
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1439 0.8594 0.8594
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0151 0.0724 0.1395
Brugia malayi gamma-secretase subunit aph-1 0.0237 0.1248 0.1248
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0701 0.4089 0.4089
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0016 0.0031
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0046 0.0084 0.0203
Giardia lamblia Histone deacetylase 0.0089 0.0346 0.1035
Echinococcus granulosus EF hand domain containing family member A2 0.0073 0.025 0.025
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1336 0.7965 0.7965
Echinococcus multilocularis prolyl endopeptidase 0.1669 1 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0989 0.0989
Trichomonas vaginalis set domain proteins, putative 0.0479 0.2731 0.5257
Echinococcus granulosus gamma secretase subunit aph 1 0.0237 0.1248 0.1248
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.006 0.0115
Loa Loa (eye worm) hypothetical protein 0.0156 0.0753 0.0753
Brugia malayi histone deacetylase 11 0.0043 0.0064 0.0064
Echinococcus multilocularis EF hand domain containing family member A2 0.0074 0.0257 0.0257
Brugia malayi hypothetical protein 0.0065 0.0199 0.0199
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0046 0.0046
Brugia malayi Calmodulin-like protein 0.0073 0.025 0.025
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0178 0.0888 0.2159
Brugia malayi cathepsin L-like cysteine proteinase 0.0194 0.0989 0.0989
Trypanosoma brucei mitochondrial calcium uptake 1 0.0073 0.025 0.025
Brugia malayi chromobox protein homolog 3 0.0044 0.0069 0.0069
Entamoeba histolytica GPI-anchor transamidase, putative 0.0035 0.0016 0.0031
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139 0.0653 0.1258
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0989 0.1904
Plasmodium vivax proteasome subunit beta type-2, putative 0.004 0.0048 0.0092
Entamoeba histolytica cysteine proteinase, putative 0.0603 0.349 0.6718
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0143 0.0677 0.1303
Echinococcus multilocularis chromatin regulatory protein sir2 0.0126 0.0571 0.0571
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.0553 0.0553
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.082 0.4814 0.4814
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0139 0.0653 0.0653
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1262 0.7516 0.7516
Onchocerca volvulus Chorion peroxidase homolog 0.0065 0.0199 0.0188
Loa Loa (eye worm) calpain family protein 1 0.0929 0.5481 0.5481
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.009 0.0078
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Echinococcus granulosus histone deacetylase 6 0.01 0.0413 0.0413
Schistosoma mansoni histone deacetylase 0.0089 0.0346 0.0346
Trichomonas vaginalis calcium binding protein, putative 0.0073 0.025 0.0482
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0476 0.2712 0.2712
Brugia malayi cathepsin B-like cysteine proteinase 0.1439 0.8594 0.8594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Schistosoma mansoni hypothetical protein 0.0169 0.0833 0.0833
Schistosoma mansoni histone deacetylase 4 5 0.01 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0063 0.0189 0.0189
Toxoplasma gondii proteasome subunit beta type, putative 0.0083 0.0312 0.0312
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0194 0.0989 0.296
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.0453 0.0453
Echinococcus granulosus peroxidasin 0.0065 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0786 0.4607 0.4607
Brugia malayi MH2 domain containing protein 0.0124 0.0559 0.0559
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0046 0.0046
Echinococcus granulosus histone deacetylase 7 0.01 0.0413 0.0413
Giardia lamblia Hypothetical protein 0.0126 0.0571 0.171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.0288 0.0288
Giardia lamblia Cathepsin L precursor 0.0194 0.0989 0.296
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0785 0.4597 0.4597
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0346 0.0666
Entamoeba histolytica cysteine protease, putative 0.0194 0.0989 0.1904
Brugia malayi calpain 5 0.0143 0.0677 0.0677
Brugia malayi hypothetical protein 0.004 0.0046 0.0046
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0046 0.0046
Entamoeba histolytica calmodulin, putative 0.0073 0.025 0.0482
Entamoeba histolytica cysteine proteinase, putative 0.0882 0.5195 1
Schistosoma mansoni hypothetical protein 0.0073 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0089
Loa Loa (eye worm) calpain family protein 1 0.1262 0.7516 0.7516
Loa Loa (eye worm) hypothetical protein 0.0238 0.1254 0.1254
Onchocerca volvulus 0.0065 0.0199 0.0188
Brugia malayi Peroxidasin 0.0065 0.0199 0.0199
Schistosoma mansoni reticulocalbin 0.0073 0.025 0.025
Onchocerca volvulus Prolyl endopeptidase homolog 0.1669 1 1
Plasmodium falciparum calpain 0.0143 0.0677 0.1303
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0882 0.5195 0.5195
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0706 0.4115 0.4115
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0476 0.2712 0.2712
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0178 0.0888 1
Toxoplasma gondii histone deacetylase HDAC2 0.0089 0.0346 0.0346
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1336 0.7965 0.7965
Trypanosoma cruzi cruzipain precursor, putative 0.098 0.5794 0.5794
Giardia lamblia Cathepsin L precursor 0.0194 0.0989 0.296
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0073 0.025 0.0482
Trypanosoma brucei centrin-3 0.0073 0.025 0.025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0171 0.0171
Plasmodium vivax proteasome subunit beta type-1, putative 0.0065 0.0198 0.0382
Trypanosoma brucei histone deacetylase 1 0.0089 0.0346 0.0346
Echinococcus granulosus centrin 2 0.0073 0.025 0.025
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0785 0.4597 0.4597
Giardia lamblia Cathepsin B precursor 0.0579 0.3341 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0178 0.0888 0.0888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Mycobacterium ulcerans proteasome PrcB 0.0083 0.0312 0.0759
Brugia malayi calcium-binding protein 0.0073 0.025 0.025
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Brugia malayi cathepsin F-like cysteine proteinase 0.0279 0.1507 0.1507
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.0366 0.0366
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0559 0.0559
Schistosoma mansoni hypothetical protein 0.0169 0.0833 0.0833
Brugia malayi proteasome subunit beta type 2 0.004 0.0048 0.0048
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.0453 0.0873
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.0046
Trypanosoma brucei proteasome beta 6 subunit 0.0065 0.0198 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0046 0.0046
Brugia malayi GPI-anchor transamidase 0.0035 0.0016 0.0016
Echinococcus granulosus cathepsin l1 0.0603 0.349 0.349
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0073 0.025 0.025
Onchocerca volvulus 0.0882 0.5195 0.5189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0194 0.0989 0.0989
Plasmodium vivax proteasome subunit beta type-5, putative 0.0083 0.0312 0.0601
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0048 0.0048
Brugia malayi Pre-SET motif family protein 0.006 0.0171 0.0171
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0989 0.0989
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0046 0.0046
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0042 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0603 0.349 0.349
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0046 0.0046
Trichomonas vaginalis calmodulin, putative 0.0074 0.0257 0.0495
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0989 0.0989
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Echinococcus multilocularis peroxidasin 0.0065 0.0199 0.0199
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0989 0.0989
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0073 0.025 0.025
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0084 0.0161
Mycobacterium tuberculosis Conserved hypothetical protein 0.0288 0.1565 0.1831
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Trichomonas vaginalis calcineurin B subunit, putative 0.0074 0.0257 0.0495
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0346 0.0666
Loa Loa (eye worm) hypothetical protein 0.0194 0.0989 0.0989
Echinococcus granulosus EF hand domain containing family member A2 0.0074 0.0257 0.0257
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0135 0.0135
Brugia malayi calpain D 0.0143 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0046 0.0081 0.0081
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0199 0.0199
Onchocerca volvulus Histone deacetylase 10 homolog 0.0043 0.0064 0.0053
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.0205 0.0205
Schistosoma mansoni axis inhibition protein axin 0.004 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0139 0.0653 0.0653
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0046 0.0046
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0084 0.0161
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0576 0.332 0.332
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0882 0.5195 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0046 0.0089
Leishmania major hypothetical protein, unknown function 0.0143 0.0677 0.0677
Trypanosoma brucei kinesin, putative 0.0333 0.1837 0.1837
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0199 0.0199
Leishmania major cathepsin L-like protease 0.098 0.5794 0.5794
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0238 0.1254 0.1254
Loa Loa (eye worm) prolyl oligopeptidase 0.082 0.4814 0.4814
Echinococcus granulosus cathepsin b 0.1439 0.8594 0.8594
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0346 0.0666
Schistosoma mansoni calpain-7 (C02 family) 0.0479 0.2731 0.2731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Echinococcus multilocularis histone deacetylase 3 0.0089 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Echinococcus multilocularis histone deacetylase 6 0.01 0.0413 0.0413
Toxoplasma gondii peptidase c13 family protein 0.0035 0.0016 0.0016
Onchocerca volvulus Legumain homolog 0.0151 0.0724 0.0714
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Schistosoma mansoni histone deacetylase 4 5 0.01 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0603 0.349 0.349
Echinococcus multilocularis calpain family protein 1, d 0.0929 0.5481 0.5481
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0576 0.332 0.332
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.0046
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0194 0.0989 0.1904
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0178 0.0888 0.171
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0989 0.0989
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0143 0.0677 0.0677
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0158 0.0158
Giardia lamblia Cathepsin L precursor 0.0194 0.0989 0.296
Echinococcus granulosus Dipeptidyl peptidase 9 0.0576 0.332 0.332
Schistosoma mansoni histone deacetylase hda2 0.0106 0.0451 0.0451
Brugia malayi histone deacetylase 3 (HD3) 0.0089 0.0346 0.0346
Trypanosoma brucei protein I/6 0.0073 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0579 0.3341 0.6432
Trypanosoma brucei calpain-like protein, putative 0.0476 0.2712 0.2712
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0073 0.025 0.025
Loa Loa (eye worm) glycogen phosphorylase 0.0107 0.0453 0.0453
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0046 0.0046
Entamoeba histolytica grainin 2 0.0073 0.025 0.0482
Plasmodium falciparum serine repeat antigen 7 0.0194 0.0989 0.1904
Schistosoma mansoni bromodomain containing protein 0.0071 0.0235 0.0235
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Echinococcus multilocularis cathepsin L cysteine protease 0.0882 0.5195 0.5195
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0238 0.1254 0.2415
Onchocerca volvulus Cathepsin F homolog 0.0882 0.5195 0.5189
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0065 0.0198 0.0198
Brugia malayi Histone deacetylase family protein 0.01 0.0413 0.0413
Toxoplasma gondii prolyl endopeptidase 0.1669 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0989 0.1904
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0603 0.349 0.349
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0004 0.0004
Onchocerca volvulus 0.0156 0.0753 0.0742
Giardia lamblia Cathepsin B precursor 0.0194 0.0989 0.296
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0102 0.0102
Brugia malayi carbohydrate phosphorylase 0.0107 0.0453 0.0453
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Trypanosoma cruzi centrin, putative 0.0073 0.025 0.025
Leishmania major silent information regulator 2, putative 0.0126 0.0571 0.0571
Plasmodium falciparum serine repeat antigen 4 0.0194 0.0989 0.1904
Loa Loa (eye worm) hypothetical protein 0.0107 0.0456 0.0456
Echinococcus granulosus cathepsin l cysteine peptidase 0.0882 0.5195 0.5195
Leishmania major centrin, putative,caltractin, putative 0.0073 0.025 0.025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0083 0.0083
Schistosoma mansoni hemoglobinase (C13 family) 0.0151 0.0724 0.0724
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1336 0.7965 0.7965
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0194 0.0989 0.1904
Schistosoma mansoni histone deacetylase 1 2 3 0.0043 0.0064 0.0064
Leishmania major cathepsin L-like protease 0.0882 0.5195 0.5195
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0046 0.0046
Entamoeba histolytica histone deacetylase, putative 0.0089 0.0346 0.0666
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0553 0.1344
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0279 0.0537
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0035 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Trypanosoma brucei calpain, putative 0.0143 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0083 0.0083
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0194 0.0989 0.1904
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.082 0.4814 0.4814
Brugia malayi jmjC domain containing protein 0.0068 0.0218 0.0218
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0065 0.0198 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0603 0.349 0.6718
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0126 0.0571 0.0571
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0046 0.0046
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1272 0.1272
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Schistosoma mansoni survival motor neuron protein 0.0049 0.0102 0.0102
Brugia malayi Bromodomain containing protein 0.0084 0.0315 0.0315
Brugia malayi Cathepsin L-like precursor 0.0882 0.5195 0.5195
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0042 0.006 0.006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0989 0.296
Trypanosoma brucei Calpain-like protein 1.2 0.0143 0.0677 0.0677
Loa Loa (eye worm) histone deacetylase 7A 0.01 0.0413 0.0413
Onchocerca volvulus 0.0065 0.0199 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.1254 0.1254
Schistosoma mansoni cathepsin F (C01 family) 0.0882 0.5195 0.5195
Loa Loa (eye worm) hypothetical protein 0.0073 0.025 0.025
Leishmania major calpain family cysteine protease-like protein 0.0143 0.0677 0.0677
Mycobacterium tuberculosis Probable peptidase 0.0706 0.4115 0.4814
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Giardia lamblia Cathepsin B precursor 0.0194 0.0989 0.296
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1439 0.8594 0.8594
Schistosoma mansoni mitochondrial solute carrier 0.0073 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0069 0.0134
Brugia malayi calpain family protein 1 0.1262 0.7516 0.7516
Loa Loa (eye worm) histone deacetylase 11 0.0043 0.0064 0.0064
Schistosoma mansoni calpain (C02 family) 0.0476 0.2712 0.2712
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0346 0.0666
Echinococcus granulosus histone lysine methyltransferase setb 0.0079 0.0288 0.0288
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139 0.0653 0.1258
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0065
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0143 0.0677 0.0677
Schistosoma mansoni ef hand domain family member A2 0.0073 0.025 0.025
Trypanosoma brucei caltractin, putative 0.0073 0.025 0.025
Schistosoma mansoni neuronal calcium sensor 0.0073 0.025 0.025
Trypanosoma brucei hypothetical protein 0.0143 0.0677 0.0677
Echinococcus multilocularis programmed cell death protein 0.0073 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0194 0.0989 0.1904
Giardia lamblia Cathepsin L precursor 0.0194 0.0989 0.296
Schistosoma mansoni regulator of G protein signaling 0.004 0.0046 0.0046
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0989 0.1904
Giardia lamblia Cathepsin B precursor 0.0579 0.3341 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0061 0.0176 0.034
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0882 0.5195 0.5195
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0042 0.006 0.006
Giardia lamblia GPI-anchor transamidase, putative 0.0035 0.0016 0.0049
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Trypanosoma brucei Calpain-like protein 2 0.0143 0.0677 0.0677
Echinococcus multilocularis histone deacetylase 1 0.0089 0.0346 0.0346
Entamoeba histolytica hypothetical protein, conserved 0.0074 0.0257 0.0495
Loa Loa (eye worm) prolyl oligopeptidase 0.0238 0.1254 0.1254
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0074 0.0257 0.0257
Giardia lamblia Cathepsin L precursor 0.0194 0.0989 0.296
Trypanosoma brucei centrin, putative 0.0073 0.025 0.025
Trypanosoma cruzi calmodulin, putative 0.0073 0.025 0.025
Trypanosoma cruzi cysteine protease, putative 0.0473 0.2694 0.2694
Brugia malayi Thioredoxin family protein 0.0288 0.1565 0.1565
Mycobacterium tuberculosis Hypothetical protein 0.0288 0.1565 0.1831
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0046 0.0046
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.0453 0.0873
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Schistosoma mansoni chromatin regulatory protein sir2 0.0139 0.0653 0.0653
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0211 0.0211
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0117 0.0514 0.0858
Schistosoma mansoni calpain-2 (C02 family) 0.0143 0.0677 0.0677
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Echinococcus granulosus proteasome prosome macropain 0.0083 0.0312 0.0312
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0073 0.025 0.025
Toxoplasma gondii calmodulin CAM1 0.0074 0.0257 0.0257
Leishmania major cathepsin L-like protease 0.0882 0.5195 0.5195
Giardia lamblia Hypothetical protein 0.0288 0.1565 0.4684
Schistosoma mansoni inhibitor of apoptosis protein 0.0039 0.0042 0.0042
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0785 0.4597 0.4597
Schistosoma mansoni chromatin regulatory protein sir2 0.0126 0.0571 0.0571
Mycobacterium ulcerans transglutaminase family protein 0.0288 0.1565 0.3803
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1431 0.8548 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0473 0.2694 0.2694
Brugia malayi Serine protease Z688.6 precursor 0.0042 0.006 0.006
Loa Loa (eye worm) peptidase C13 family protein 0.0151 0.0724 0.0724
Schistosoma mansoni axis inhibition protein axin 0.004 0.0046 0.0046
Brugia malayi cathepsin F-like cysteine proteinase 0.0194 0.0989 0.0989
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0178 0.0888 0.171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Leishmania major centrin, putative 0.0073 0.025 0.025
Schistosoma mansoni hypothetical protein 0.0288 0.1565 0.1565
Entamoeba histolytica cysteine protease, putative 0.0194 0.0989 0.1904
Echinococcus granulosus neurocalcin 0.0073 0.025 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Echinococcus granulosus geminin 0.0169 0.0833 0.0833
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0042 0.006 0.0115
Echinococcus granulosus prolyl endopeptidase 0.1669 1 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0346 0.0666
Echinococcus multilocularis GPI anchor transamidase 0.0035 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0882 0.5195 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0004 0.0009
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0989 0.296
Trypanosoma cruzi kinesin, putative 0.0333 0.1837 0.1837
Toxoplasma gondii histone deacetylase HDAC3 0.0089 0.0346 0.0346
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0989 0.1904
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0143 0.0677 0.0677
Brugia malayi Pre-SET motif family protein 0.0421 0.2375 0.2375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0473 0.2694 0.5186
Plasmodium falciparum centrin-1 0.0073 0.025 0.0482
Trichomonas vaginalis calcium binding proteins, putative 0.0073 0.025 0.0482
Brugia malayi Histone deacetylase 1 0.0089 0.0346 0.0346
Echinococcus multilocularis histone deacetylase 0.01 0.0413 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Giardia lamblia Cysteine protease 0.0194 0.0989 0.296
Schistosoma mansoni reticulocalbin 0.0074 0.0257 0.0257
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0004 0.0004
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0126 0.0571 0.11
Leishmania major calmodulin-like protein 0.0073 0.025 0.025
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0046 0.0046
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0065 0.0198 0.0198
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.0453 0.0873
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.0064
Leishmania major histone deacetylase, putative 0.01 0.0413 0.0413
Trypanosoma brucei oligopeptidase b 0.0706 0.4115 0.4115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Leishmania major cathepsin L-like protease 0.0882 0.5195 0.5195
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0046 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0882 0.5195 0.5195
Brugia malayi EF hand family protein 0.0074 0.0257 0.0257
Echinococcus multilocularis cathepsin b 0.1439 0.8594 0.8594
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0706 0.4115 0.4814
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0046 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0257 0.0495
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0346 0.0666
Entamoeba histolytica calpain family cysteine protease, putative 0.0143 0.0677 0.1303
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.0151 0.0724 0.0724
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0194 0.0989 0.1904
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0126 0.0571 0.11
Brugia malayi jmjC domain containing protein 0.0066 0.0205 0.0205
Echinococcus multilocularis proteasome (prosome, macropain) 0.0083 0.0312 0.0312
Echinococcus multilocularis cysteine protease 0.0882 0.5195 0.5195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Echinococcus granulosus cathepsin L 0.0473 0.2694 0.2694
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0046 0.0046
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0989 0.0989
Toxoplasma gondii cathepsin B 0.0579 0.3341 0.3341
Plasmodium falciparum GPI-anchor transamidase, putative 0.0035 0.0016 0.0031
Trypanosoma brucei prolyl oligopeptidase, putative 0.0706 0.4115 0.4115
Schistosoma mansoni cathepsin s 0.0279 0.1507 0.1507
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0989 0.1904
Brugia malayi cathepsin L precursor 0.0194 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0349 0.1934 0.1934
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0042 0.006 0.006
Onchocerca volvulus 0.0073 0.0249 0.0238
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0237 0.1248 0.1248
Schistosoma mansoni hypothetical protein 0.0039 0.0042 0.0042
Plasmodium falciparum serine repeat antigen 3 0.0194 0.0989 0.1904
Entamoeba histolytica hypothetical protein, conserved 0.0238 0.1254 0.2415
Onchocerca volvulus 0.0073 0.025 0.0239
Loa Loa (eye worm) histone deacetylase 3 0.0089 0.0346 0.0346
Entamoeba histolytica cysteine proteinase, putative 0.0473 0.2694 0.5186
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0199 0.0188
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0194 0.0989 0.1904
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Mycobacterium leprae Conserved hypothetical protein 0.0288 0.1565 0.3526
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Echinococcus multilocularis calpain 7 (C02 family) 0.0476 0.2712 0.2712
Echinococcus granulosus calcium uptake protein 1 0.0074 0.0257 0.0257
Schistosoma mansoni cathepsin C 0.0194 0.0989 0.0989
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0143 0.0677 0.1303
Trypanosoma cruzi caltractin, putative 0.0073 0.025 0.025
Loa Loa (eye worm) fibroinase 0.0882 0.5195 0.5195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0279 0.1507 0.1507
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0178 0.0888 0.5
Trypanosoma brucei cysteine peptidase, putative 0.0143 0.0677 0.0677
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.082 0.4814 0.4814
Leishmania major calcineurin B subunit, putative 0.0073 0.025 0.025
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139 0.0653 0.1258
Brugia malayi cathepsin L-like precursor 0.0603 0.349 0.349
Echinococcus granulosus programmed cell death protein 0.0073 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0194 0.0989 0.1904
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0079 0.0288 0.0288
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0238 0.1254 0.2415
Plasmodium falciparum cysteine proteinase falcipain 3 0.0882 0.5195 1
Leishmania major histone deacetylase, putative 0.0089 0.0346 0.0346
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.004 0.0048 0.0048
Schistosoma mansoni neuronal calcium sensor 0.0073 0.025 0.025
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Trypanosoma brucei histone deacetylase, putative 0.01 0.0413 0.0413
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0553 0.0553
Entamoeba histolytica hypothetical protein 0.004 0.0046 0.0089
Plasmodium vivax unspecified product 0.0279 0.1507 0.2901
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.0046
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0989 0.1904
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0016 0.0031
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0035 0.0016 0.0016
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0048 0.0048
Brugia malayi EF hand family protein 0.0073 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Leishmania major calmodulin, putative 0.0073 0.025 0.025
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0151 0.0724 0.1395
Onchocerca volvulus Peroxidase homolog 0.0065 0.0199 0.0188
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0065 0.0198 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Brugia malayi prolyl oligopeptidase family protein 0.082 0.4814 0.4814
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0238 0.1254 0.1254
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0065 0.0198 0.0198
Echinococcus multilocularis calpain 5 0.0476 0.2712 0.2712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0171 0.0171
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0151 0.0724 0.1395
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0199 0.0199
Brugia malayi transcriptional regulator, Sir2 family protein 0.0126 0.0571 0.0571
Toxoplasma gondii preprocathepsin c precursor, putative 0.0194 0.0989 0.0989
Brugia malayi Serine carboxypeptidase S28 family protein 0.0042 0.006 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0989 0.0989
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0238 0.1254 0.1254
Loa Loa (eye worm) hypothetical protein 0.0279 0.1507 0.1507
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1669 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0553 0.1344
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0553 0.0553
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0218 0.0218
Schistosoma mansoni rab 0.0073 0.025 0.025
Leishmania major hypothetical protein, conserved 0.0073 0.025 0.025
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0064 0.0064
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0576 0.332 0.332
Schistosoma mansoni regulator of G protein signaling 0.004 0.0046 0.0046
Echinococcus granulosus histone deacetylase 8 0.0043 0.0064 0.0064
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0677 0.0677
Trypanosoma cruzi cysteine peptidase, putative 0.098 0.5794 0.5794
Trypanosoma cruzi oligopeptidase b 0.0706 0.4115 0.4115
Leishmania major proteasome beta 2 subunit, putative 0.004 0.0048 0.0048
Toxoplasma gondii hypothetical protein 0.0143 0.0677 0.0677
Onchocerca volvulus 0.0882 0.5195 0.5189
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0706 0.4115 1
Plasmodium vivax GPI-anchor transamidase, putative 0.0035 0.0016 0.0031
Plasmodium vivax vivapain-2 0.0882 0.5195 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.0312 0.0312
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0706 0.4115 1
Brugia malayi hypothetical protein 0.024 0.1272 0.1272
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0083 0.0312 0.0934
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0065 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Trichomonas vaginalis calmodulin-2, putative 0.0073 0.025 0.0482
Loa Loa (eye worm) hypothetical protein 0.0079 0.0288 0.0288
Schistosoma mansoni peroxidasin 0.0065 0.0199 0.0199
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0048 0.0092
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0046 0.0046
Giardia lamblia Cathepsin L precursor 0.0194 0.0989 0.296
Brugia malayi Heterochromatin protein 1 0.0078 0.0279 0.0279
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0194 0.0989 0.1904
Toxoplasma gondii EFHC1, putative 0.0073 0.025 0.025
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0989 0.296
Brugia malayi Bromodomain containing protein 0.0043 0.0064 0.0064
Onchocerca volvulus 0.0786 0.4607 0.46
Schistosoma mansoni calmodulin 0.0073 0.025 0.025
Loa Loa (eye worm) transcriptional regulator 0.0126 0.0571 0.0571
Schistosoma mansoni centrin-related 0.0073 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Trypanosoma cruzi I/6 autoantigen, putative 0.0073 0.025 0.025
Toxoplasma gondii histone deacetylase HDAC4 0.0043 0.0064 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.1421 0.8488 0.8488
Giardia lamblia Encystation-specific protease 0.0194 0.0989 0.296
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0559 0.0559
Trypanosoma brucei I/6 autoantigen 0.0073 0.025 0.025
Leishmania major hypothetical protein, conserved 0.0074 0.0257 0.0257
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0279 0.1507 0.1507
Toxoplasma gondii calcium-dependent protein kinase 0.0074 0.0257 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Leishmania major cathepsin L-like protease 0.0882 0.5195 0.5195
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Leishmania major centrin, putative 0.0073 0.025 0.025
Giardia lamblia Cathepsin B precursor 0.0194 0.0989 0.296
Trypanosoma cruzi prolyl endopeptidase 0.1669 1 1
Echinococcus granulosus calpain 0.0476 0.2712 0.2712
Toxoplasma gondii EF hand domain-containing protein 0.0073 0.025 0.025
Echinococcus granulosus cathepsin L cysteine proteinase 0.0882 0.5195 0.5195
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0677 0.0677
Entamoeba histolytica cysteine protease, putative 0.0194 0.0989 0.1904
Echinococcus multilocularis calumenin 0.0074 0.0257 0.0257
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0346 0.0666
Trichomonas vaginalis calcium binding protein, putative 0.0073 0.025 0.0482
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0194 0.0989 0.0989
Plasmodium vivax centrin-1, putative 0.0073 0.025 0.0482
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0218 0.0218
Echinococcus granulosus glycogen phosphorylase 0.0107 0.0453 0.0453
Brugia malayi hypothetical protein 0.0227 0.1188 0.1188
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0238 0.1254 0.2415
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0073 0.025 0.0482
Plasmodium falciparum cysteine proteinase falcipain 1 0.0473 0.2694 0.5186
Loa Loa (eye worm) calpain 5 0.0333 0.1837 0.1837
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0046 0.0046
Echinococcus granulosus tumor protein p63 0.0348 0.1928 0.1928
Onchocerca volvulus 0.0042 0.006 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0579 0.3341 0.3341
Trypanosoma cruzi cysteine peptidase, putative 0.0882 0.5195 0.5195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0989 0.1904
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0089
Trichomonas vaginalis peptide N-glycanase, putative 0.0288 0.1565 0.3013
Schistosoma mansoni chromatin regulatory protein sir2 0.0126 0.0571 0.0571
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0083 0.0312 0.0601
Schistosoma mansoni regulator of G protein signaling 0.004 0.0046 0.0046
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0194 0.0989 0.1904
Trichomonas vaginalis calpain, putative 0.0143 0.0677 0.1303
Brugia malayi Cathepsin L-like precursor 0.0603 0.349 0.349
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0199 0.0199
Schistosoma mansoni neuronal calcium sensor 0.0073 0.025 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0126 0.0571 0.0571
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0083 0.0312 0.0312
Echinococcus multilocularis cathepsin L 0.0473 0.2694 0.2694
Leishmania major cathepsin L-like protease 0.098 0.5794 0.5794
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.025 0.0482
Echinococcus granulosus chromobox protein 1 0.0078 0.0279 0.0279
Onchocerca volvulus 0.048 0.2732 0.2724
Onchocerca volvulus 0.0882 0.5195 0.5189
Toxoplasma gondii cathepsin CPL 0.0882 0.5195 0.5195
Trypanosoma cruzi cysteine proteinase, putative 0.0473 0.2694 0.2694
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0989 0.1904
Echinococcus granulosus proteasome prosome macropain subunit beta 0.004 0.0048 0.0048
Trypanosoma cruzi I/6 autoantigen, putative 0.0073 0.025 0.025
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Brugia malayi Papain family cysteine protease containing protein 0.0882 0.5195 0.5195
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0579 0.3341 0.3341
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.082 0.4814 0.4808
Echinococcus multilocularis histone deacetylase 7 0.01 0.0413 0.0413
Echinococcus multilocularis inhibitor of apoptosis protein 0.0039 0.0042 0.0042
Echinococcus multilocularis programmed cell death protein 0.0073 0.025 0.025
Brugia malayi NAD-dependent deacetylase SIRT1 0.0139 0.0653 0.0653
Trichomonas vaginalis chromobox protein, putative 0.0047 0.009 0.0173
Echinococcus multilocularis calbindin 32 0.0074 0.0257 0.0257
Giardia lamblia Cathepsin B precursor 0.0194 0.0989 0.296
Schistosoma mansoni gamma-secretase subunit aph-1 0.0237 0.1248 0.1248
Plasmodium falciparum serine repeat antigen 1 0.0194 0.0989 0.1904
Trichomonas vaginalis myosin light chain 1, putative 0.0073 0.025 0.0482
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0989 0.0989
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2375 0.2375
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Echinococcus multilocularis chromobox protein 1 0.0078 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Brugia malayi calpain 7 0.0476 0.2712 0.2712
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0042 0.006 0.006
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Giardia lamblia Cysteine protease 0.0194 0.0989 0.296
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0039 0.0042 0.0042
Trichomonas vaginalis calcineurin B subunit, putative 0.0073 0.025 0.0482
Trypanosoma cruzi cysteine peptidase, putative 0.0473 0.2694 0.2694
Loa Loa (eye worm) hypothetical protein 0.0079 0.0286 0.0286
Plasmodium vivax vivapain-2 0.0882 0.5195 1
Leishmania major hypothetical protein, conserved 0.0143 0.0677 0.0677
Brugia malayi PXA domain containing protein 0.004 0.0046 0.0046
Trypanosoma brucei prolyl endopeptidase 0.1669 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0126 0.0571 0.11
Toxoplasma gondii hypothetical protein 0.0238 0.1254 0.1254
Trypanosoma cruzi histone deacetylase 1, putative 0.0089 0.0346 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0989 0.1904
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0064 0.0064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0677 0.0677
Trypanosoma brucei Calpain-like protein 1.1 0.0143 0.0677 0.0677
Schistosoma mansoni memapsin-2 (A01 family) 0.0433 0.2449 0.2449
Schistosoma mansoni cathepsin B (C01 family) 0.0194 0.0989 0.0989
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0989 0.0989
Entamoeba histolytica prolyl oligopeptidase family protein 0.0238 0.1254 0.2415
Echinococcus multilocularis gamma secretase subunit aph 1 0.0237 0.1248 0.1248
Entamoeba histolytica cysteine proteinase, putative 0.0473 0.2694 0.5186
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0476 0.2712 0.2712
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0989 0.0989
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0143 0.0677 0.0677
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1669 1 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0464 0.264 0.264
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0046 0.0046
Schistosoma mansoni jumonji domain containing protein 0.0066 0.0205 0.0205
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0039 0.0042 0.0042
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0046 0.0046
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0089 0.0346 0.0666
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0046 0.0046
Brugia malayi Blistered cuticle protein 3 0.0065 0.0199 0.0199
Brugia malayi Papain family cysteine protease containing protein 0.0473 0.2694 0.2694
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.0553 0.0553
Echinococcus multilocularis cathepsin b 0.1439 0.8594 0.8594
Giardia lamblia Cathepsin L-like protease 0.0194 0.0989 0.296
Plasmodium vivax histone deacetylase 1, putative 0.0089 0.0346 0.0666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.004 0.0048 0.0092
Entamoeba histolytica cysteine protease, putative 0.0194 0.0989 0.1904
Leishmania major cysteine peptidase A (CPA) 0.0882 0.5195 0.5195
Loa Loa (eye worm) hypothetical protein 0.0051 0.0113 0.0113
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0989 0.1904
Brugia malayi Cathepsin L-like cysteine proteinase 0.0603 0.349 0.349
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.006 0.0115
Toxoplasma gondii hypothetical protein 0.0061 0.0176 0.0176
Echinococcus multilocularis histone deacetylase 6 0.0106 0.0451 0.0451
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0117 0.0514 0.0602
Giardia lamblia Proteasome subunit beta type 1 0.0065 0.0198 0.0594
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0042 0.006 0.0115
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0046 0.0046
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Echinococcus granulosus EF HAND 1 calcium binding site 0.0073 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0194 0.0989 0.1904
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0199 0.0199
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0046 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.1669 1 1
Trypanosoma cruzi calmodulin, putative 0.0073 0.025 0.025
Brugia malayi histone deacetylase 1 (HD1) 0.0089 0.0346 0.0346
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0473 0.2694 0.5186
Brugia malayi Cathepsin L-like precursor 0.0882 0.5195 0.5195
Loa Loa (eye worm) calpain 0.0476 0.2712 0.2712
Loa Loa (eye worm) RGS-3 protein 0.004 0.0046 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0083 0.0083
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0476 0.2712 0.2712
Echinococcus multilocularis calmodulin 0.0073 0.025 0.025
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0151 0.0724 0.1395
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0211 0.0211
Trypanosoma brucei proteasome subunit beta type-2, putative 0.004 0.0048 0.0048
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0064 0.0064
Echinococcus granulosus cathepsin L cysteine protease 0.0473 0.2694 0.2694
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0069 0.0058
Giardia lamblia Glycogen phosphorylase 0.0107 0.0453 0.1357
Trypanosoma brucei antigen, putative 0.0476 0.2712 0.2712
Echinococcus granulosus axis inhibition protein axin 0.004 0.0046 0.0046
Brugia malayi calpain family protein 1 0.1262 0.7516 0.7516
Schistosoma mansoni neuronal calcium sensor 0.0073 0.025 0.025
Onchocerca volvulus 0.0039 0.0042 0.003
Loa Loa (eye worm) hypothetical protein 0.0178 0.0888 0.0888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0989 0.1904
Schistosoma mansoni chromobox protein 0.0078 0.0279 0.0279
Giardia lamblia Thymus-specific serine protease precursor 0.0042 0.006 0.0179
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.025 0.025
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0989 0.0989
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0143 0.0677 0.1303
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0151 0.0724 0.1395
Loa Loa (eye worm) hypothetical protein 0.0194 0.0989 0.0989
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0476 0.2712 0.2712
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0073 0.025 0.0482
Entamoeba histolytica hypothetical protein 0.0194 0.0989 0.1904
Toxoplasma gondii cathepsin CPC2 0.0194 0.0989 0.0989
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0061 0.0176 0.034
Giardia lamblia Cathepsin L-like protease 0.0194 0.0989 0.296
Trichomonas vaginalis calcium binding protein, putative 0.0073 0.025 0.0482
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0065 0.0198 0.0382
Giardia lamblia Proteasome subunit beta type 2 0.004 0.0048 0.0143
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0989 0.1904
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0046 0.0046
Plasmodium falciparum histone deacetylase 1 0.0089 0.0346 0.0666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0473 0.2694 0.2694
Onchocerca volvulus 0.0882 0.5195 0.5189
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0279 0.0537
Giardia lamblia Cysteine protease 0.0194 0.0989 0.296
Echinococcus multilocularis Transglutaminase 0.0288 0.1565 0.1565
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0083 0.0083
Leishmania major kinesin, putative 0.0333 0.1837 0.1837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Loa Loa (eye worm) histone deacetylase 1 0.0089 0.0346 0.0346
Brugia malayi hypothetical protein 0.004 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0194 0.0989 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0089
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0178 0.0888 0.0888
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1439 0.8594 0.8594
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0143 0.0677 0.1303
Brugia malayi Cathepsin L-like precursor 0.0882 0.5195 0.5195
Onchocerca volvulus 0.0194 0.0989 0.0979
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0989 0.1904
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0042 0.006 0.006
Echinococcus multilocularis chromobox protein 1 0.0078 0.0279 0.0279
Trypanosoma brucei calpain-like protein, putative 0.0476 0.2712 0.2712
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Onchocerca volvulus Cathepsin L homolog 0.0882 0.5195 0.5189
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1336 0.7965 0.7965
Giardia lamblia Serine peptidase, putative 0.0042 0.006 0.0179
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0046 0.0046
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0279 0.0279
Entamoeba histolytica hypothetical protein 0.004 0.0046 0.0089
Schistosoma mansoni hemoglobinase (C13 family) 0.0151 0.0724 0.0724
Brugia malayi prolyl oligopeptidase family protein 0.0238 0.1254 0.1254
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0046 0.0046
Trypanosoma cruzi oligopeptidase b 0.0706 0.4115 0.4115
Echinococcus multilocularis calpain A 0.1337 0.7972 0.7972
Loa Loa (eye worm) hypothetical protein 0.0089 0.0346 0.0346
Entamoeba histolytica cysteine proteinase 2 0.0473 0.2694 0.5186
Echinococcus granulosus calumenin 0.0074 0.0257 0.0257
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0413 0.0413
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Plasmodium falciparum proteasome subunit beta type-5 0.0083 0.0312 0.0601
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0046 0.0084 0.0098
Echinococcus granulosus histone deacetylase 3 0.0089 0.0346 0.0346
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0198 0.0382
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.0366 0.0366
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Entamoeba histolytica cysteine protease, putative 0.0882 0.5195 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0989 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0989 0.1904
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.0046
Onchocerca volvulus 0.0051 0.0113 0.0102
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1272 0.1272
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0989 0.1904
Mycobacterium tuberculosis Conserved protein 0.0288 0.1565 0.1831
Entamoeba histolytica cysteine proteinase, putative 0.0473 0.2694 0.5186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0199 0.0199
Brugia malayi Probable ClpP-like protease 0.0178 0.0888 0.0888
Echinococcus granulosus cathepsin b 0.1439 0.8594 0.8594
Toxoplasma gondii centrin, putative 0.0073 0.025 0.025
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0004 0.0004
Echinococcus granulosus axis inhibition protein axin 0.004 0.0046 0.0046
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0126 0.0571 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0083 0.0083
Trypanosoma cruzi major cysteine proteinase, putative 0.0194 0.0989 0.0989
Plasmodium falciparum serine repeat antigen 5 0.0194 0.0989 0.1904
Echinococcus multilocularis acylamino acid releasing enzyme 0.0238 0.1254 0.1254
Echinococcus granulosus neuronal calcium sensor 0.0073 0.025 0.025
Entamoeba histolytica hypothetical protein 0.004 0.0046 0.0089
Echinococcus multilocularis tumor protein p63 0.0348 0.1928 0.1928
Entamoeba histolytica cysteine proteinase, putative 0.0473 0.2694 0.5186
Echinococcus granulosus expressed protein 0.0778 0.4553 0.4553
Giardia lamblia Cathepsin B precursor 0.0194 0.0989 0.296
Leishmania major calmodulin-like protein 0.0073 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0046 0.0046
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0083 0.0083
Mycobacterium ulcerans hypothetical protein 0.0288 0.1565 0.3803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0603 0.349 0.6718
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0089
Echinococcus multilocularis calmodulin 0.0073 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.006
Entamoeba histolytica cysteine protease, putative 0.0194 0.0989 0.1904
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0553 0.1344
Schistosoma mansoni peptidase Clp (S14 family) 0.0178 0.0888 0.0888
Schistosoma mansoni chromatin regulatory protein sir2 0.0126 0.0571 0.0571
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Loa Loa (eye worm) hypothetical protein 0.0194 0.0989 0.0989
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0178 0.0888 1
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0083 0.0312 0.0345
Toxoplasma gondii cathepsin CPC1 0.0194 0.0989 0.0989
Echinococcus granulosus calpain 7 C02 family 0.0476 0.2712 0.2712
Brugia malayi Cytochrome P450 family protein 0.0054 0.0135 0.0135
Plasmodium falciparum serine repeat antigen 6 0.0194 0.0989 0.1904
Plasmodium vivax vivapain-3 0.0473 0.2694 0.5186
Loa Loa (eye worm) programmed cell death protein 6 0.0074 0.0257 0.0257
Echinococcus granulosus cysteine protease 0.0473 0.2694 0.2694
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0194 0.0989 0.1904
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0989 0.1904
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0069 0.0134
Onchocerca volvulus Dual oxidase homolog 0.0065 0.0199 0.0188
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0042 0.006 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Trichomonas vaginalis calpain, putative 0.0143 0.0677 0.1303
Brugia malayi Cytochrome P450 family protein 0.0033 0.0004 0.0004
Mycobacterium leprae Conserved hypothetical protein 0.0288 0.1565 0.3526
Brugia malayi Cathepsin L-like precursor 0.0882 0.5195 0.5195
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0151 0.0724 0.1395
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0073 0.025 0.025
Plasmodium falciparum histone deacetylase 2 0.01 0.0413 0.0795
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0083 0.0312 0.0312
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0083 0.0312 0.0312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0882 0.5195 1
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.1507 0.1507
Trypanosoma brucei centrin, putative 0.0073 0.025 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Trypanosoma brucei calpain, putative 0.0143 0.0677 0.0677
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0073 0.025 0.025
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0882 0.5195 0.5195
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.006
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0706 0.4115 0.4115
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0194 0.0989 0.1904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0333 0.1837 0.3537
Onchocerca volvulus 0.0074 0.0257 0.0246
Brugia malayi Serine protease Z688.6 precursor 0.0042 0.006 0.006
Loa Loa (eye worm) cysteine protease 0.0882 0.5195 0.5195
Schistosoma mansoni regulator of G protein signaling 0.004 0.0046 0.0046
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0194 0.0989 0.1904
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Plasmodium vivax SET domain protein, putative 0.006 0.0171 0.033
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0882 0.5195 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0171 0.0171
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0473 0.2694 0.2694
Entamoeba histolytica prolyl oligopeptidase family protein 0.0238 0.1254 0.2415
Leishmania major histone deacetylase, putative 0.0089 0.0346 0.0346
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0139 0.0653 0.0653
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0576 0.332 0.332
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.0553 0.0553
Echinococcus multilocularis cysteine protease 0.0882 0.5195 0.5195
Plasmodium vivax calpain, putative 0.0476 0.2712 0.5221
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.1254 0.2415
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0882 0.5195 0.5195
Schistosoma mansoni peroxidasin 0.0065 0.0199 0.0199
Brugia malayi Cathepsin L-like precursor 0.0882 0.5195 0.5195
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.0143 0.0677 0.0677
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0083 0.0083
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0046 0.0046
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0039 0.0042 0.0042
Echinococcus granulosus peptidase Clp S14 family 0.0117 0.0514 0.0514
Schistosoma mansoni histone deacetylase 0.0089 0.0346 0.0346
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0279 0.1507 0.1507
Schistosoma mansoni calmodulin related calcium binding protein 0.0073 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0227 0.1188 0.1188
Echinococcus multilocularis cathepsin L cysteine protease 0.0882 0.5195 0.5195
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0199 0.0188
Schistosoma mansoni calmodulin 0.0073 0.025 0.025
Echinococcus granulosus chromatin regulatory protein sir2 0.0126 0.0571 0.0571
Plasmodium falciparum peptidase, putative 0.0238 0.1254 0.2415
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.0453 0.0453
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0194 0.0989 0.0989
Schistosoma mansoni Mername-AA248 (C02 family) 0.0476 0.2712 0.2712
Schistosoma mansoni regulator of G protein signaling 0.004 0.0046 0.0046
Entamoeba histolytica calcium binding family protein 0.0073 0.025 0.0482
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0073 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.006 0.0115
Leishmania major protein kinase, putative 0.0073 0.025 0.025
Trypanosoma brucei calmodulin, putative 0.0074 0.0257 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Echinococcus multilocularis calpain 0.0476 0.2712 0.2712
Schistosoma mansoni chromobox protein 0.0078 0.0279 0.0279
Brugia malayi fibroinase precursor 0.0194 0.0989 0.0989
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.0553 0.0553
Trypanosoma brucei histone deacetylase 4 0.01 0.0413 0.0413
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0035 0.0016 0.0031
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Schistosoma mansoni hypothetical protein 0.0116 0.051 0.051
Echinococcus granulosus GPI anchor transamidase 0.0035 0.0016 0.0016
Leishmania major programmed cell death 6 protein-like protein 0.0073 0.025 0.025
Onchocerca volvulus Glycogen phosphorylase homolog 0.0107 0.0453 0.0442
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0074 0.0257 0.0257
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0139 0.0653 0.1258
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0126 0.0571 0.0571
Entamoeba histolytica cysteine proteinase, putative 0.0882 0.5195 1
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Trypanosoma brucei cysteine peptidase C (CPC) 0.0579 0.3341 0.3341
Trypanosoma brucei Aph-1 protein, putative 0.0092 0.0366 0.0366
Trypanosoma cruzi conserved protein 0.0143 0.0677 0.0677
Echinococcus granulosus inhibitor of apoptosis protein 0.0039 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Loa Loa (eye worm) calpain D 0.0143 0.0677 0.0677
Entamoeba histolytica protein kinase, putative 0.0333 0.1837 0.3537
Brugia malayi Histone deacetylase family protein 0.01 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0929 0.5481 0.5481
Plasmodium vivax histone deacetylase, putative 0.01 0.0413 0.0795
Trypanosoma cruzi cysteine peptidase, putative 0.098 0.5794 0.5794
Trypanosoma cruzi major cysteine proteinase, putative 0.0292 0.1588 0.1588
Trichomonas vaginalis centrin, putative 0.0073 0.025 0.0482
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0218 0.0218
Mycobacterium tuberculosis Long conserved protein 0.0288 0.1565 0.1831
Trypanosoma cruzi histone deacetylase 1, putative 0.0089 0.0346 0.0346
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Schistosoma mansoni calpain C (C02 family) 0.0476 0.2712 0.2712
Plasmodium vivax histone deacetylase 2, putative 0.01 0.0413 0.0795
Echinococcus granulosus calpain A 0.1337 0.7972 0.7972
Loa Loa (eye worm) calmodulin-like protein 0.0073 0.025 0.025
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0113 0.0113
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0143 0.0677 0.0677
Brugia malayi PXA domain containing protein 0.004 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Entamoeba histolytica cysteine protease, putative 0.0473 0.2694 0.5186
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0677 0.0677
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0249 0.0249
Giardia lamblia Transglutaminase/protease, putative 0.0288 0.1565 0.4684
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0132 0.061 0.1173
Brugia malayi programmed cell death protein 6 0.0073 0.025 0.025
Trichomonas vaginalis hypothetical protein 0.0143 0.0677 0.1303
Giardia lamblia Alanyl dipeptidyl peptidase 0.0238 0.1254 0.3754
Brugia malayi proteasome subunit beta type 1 0.0065 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0279 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0194 0.0989 0.0989
Schistosoma mansoni glycogen phosphorylase 0.0107 0.0453 0.0453
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.0453 0.0873
Trypanosoma cruzi cysteine proteinase, putative 0.0473 0.2694 0.2694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Onchocerca volvulus 0.0882 0.5195 0.5189
Trypanosoma brucei Calpain-like protein CALP1.3 0.0143 0.0677 0.0677
Echinococcus granulosus histone deacetylase 1 0.0089 0.0346 0.0346
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0143 0.0677 0.1303
Trichomonas vaginalis histone deacetylase, putative 0.0089 0.0346 0.0666
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0989 0.1904
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0143 0.0677 0.0677
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Onchocerca volvulus 0.0288 0.1565 0.1555
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1669 1 1
Echinococcus multilocularis neurocalcin 0.0073 0.025 0.025
Echinococcus granulosus calpain A 0.0476 0.2712 0.2712
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1439 0.8594 0.8594
Leishmania major proteasome beta 5 subunit, putative 0.0083 0.0312 0.0312
Trypanosoma cruzi centrin, putative 0.0073 0.025 0.025
Onchocerca volvulus Deterin homolog 0.0039 0.0042 0.003
Toxoplasma gondii histone deacetylase HDAC5 0.0043 0.0066 0.0066
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0677 0.0677
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0706 0.4115 0.4115
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0073 0.025 0.025
Brugia malayi prolyl oligopeptidase family protein 0.0576 0.332 0.332
Brugia malayi hypothetical protein 0.0156 0.0753 0.0753
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0882 0.5195 1
Onchocerca volvulus Peroxidase homolog 0.0065 0.0199 0.0188
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0046 0.0046
Leishmania major calmodulin, putative 0.0073 0.025 0.025
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0178 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0194 0.0989 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.006 0.0115
Plasmodium falciparum serine repeat antigen 9 0.0194 0.0989 0.1904
Trypanosoma cruzi hypothetical protein, conserved 0.0238 0.1254 0.1254
Trichomonas vaginalis chromobox protein, putative 0.0047 0.009 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0989 0.1904
Brugia malayi Cathepsin L-like precursor 0.0882 0.5195 0.5195
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0473 0.2694 0.2694
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0218 0.0218
Giardia lamblia Hypothetical protein 0.0074 0.0257 0.077
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0194 0.0989 0.1904
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0413 0.0413
Leishmania major calpain protease-like protein 0.0143 0.0677 0.0677
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0178 0.0888 0.0888
Giardia lamblia Hypothetical protein 0.0194 0.0989 0.296
Loa Loa (eye worm) histone deacetylase 0.01 0.0413 0.0413
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Toxoplasma gondii centrin 0.0073 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0677 0.1303
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0312 0.0601
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0089
Loa Loa (eye worm) hypothetical protein 0.0057 0.0151 0.0151
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0073 0.025 0.025
Trypanosoma brucei calpain-like protein, putative 0.0476 0.2712 0.2712
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.024 0.1272 0.1272
Schistosoma mansoni centrin 0.0073 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0143 0.0677 0.0677
Echinococcus granulosus chromobox protein 1 0.0078 0.0279 0.0279
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0706 0.4115 0.4115
Leishmania major cathepsin L-like protease 0.098 0.5794 0.5794
Loa Loa (eye worm) ctsf protein 0.0882 0.5195 0.5195
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0039 0.0042 0.0042
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0073 0.025 0.025
Entamoeba histolytica grainin, putative 0.0074 0.0257 0.0495
Onchocerca volvulus Cathepsin L homolog 0.0194 0.0989 0.0979
Leishmania major histone deacetylase, putative 0.01 0.0413 0.0413
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0579 0.3341 0.3341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0046 0.0046
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0198 0.0198
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0198 0.0198
Giardia lamblia Hypothetical protein 0.0194 0.0989 0.296
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0989 0.0989
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0473 0.2694 0.2694
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0151 0.0724 0.1395
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0035 0.0016 0.0016
Echinococcus granulosus microtubule associated protein 2 0.1421 0.8488 0.8488
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0476 0.2712 0.2712
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0576 0.332 0.332
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1439 0.8594 0.8594
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0476 0.2712 0.2712
Echinococcus granulosus Glycosyl transferase family 35 0.0107 0.0453 0.0453
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0073 0.025 0.025
Echinococcus multilocularis EF hand domain containing family member A2 0.0073 0.025 0.025
Plasmodium vivax histone deacetylase, putative 0.0043 0.0064 0.0124
Leishmania major i/6 autoantigen-like protein 0.0073 0.025 0.025
Echinococcus granulosus histone deacetylase 0.01 0.0413 0.0413
Echinococcus granulosus histone deacetylase 6 0.0106 0.0451 0.0451
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.0312 0.0312
Schistosoma mansoni cathepsin S (C01 family) 0.0194 0.0989 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0882 0.5195 1
Plasmodium falciparum histone deacetylase, putative 0.01 0.0413 0.0795
Entamoeba histolytica cysteine protease, putative 0.0194 0.0989 0.1904
Echinococcus granulosus acylamino acid releasing enzyme 0.0238 0.1254 0.1254
Loa Loa (eye worm) hypothetical protein 0.0882 0.5195 0.5195
Echinococcus multilocularis geminin 0.0169 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.1119 0.6642 0.6642
Leishmania major cathepsin L-like protease 0.0882 0.5195 0.5195
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0143 0.0677 0.0677
Schistosoma mansoni glycogen phosphorylase 0.0046 0.0084 0.0084
Onchocerca volvulus 0.0065 0.0199 0.0188
Toxoplasma gondii proteasome subunit beta type 2, putative 0.004 0.0048 0.0048
Plasmodium falciparum serine repeat antigen 2 0.0194 0.0989 0.1904
Brugia malayi Cathepsin L-like precursor 0.0603 0.349 0.349
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0046 0.0046
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0238 0.1254 0.2415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0989 0.1904
Brugia malayi Peptidase C13 family protein 0.0151 0.0724 0.0724
Loa Loa (eye worm) hypothetical protein 0.0073 0.025 0.025
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0117 0.0514 0.0602
Echinococcus multilocularis neuronal calcium sensor 0.0073 0.025 0.025
Onchocerca volvulus 0.0882 0.5195 0.5189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0476 0.2712 0.2712
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0199 0.0199
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0238 0.1254 0.1254
Schistosoma mansoni calpain-7 (C02 family) 0.0479 0.2731 0.2731
Echinococcus granulosus calbindin 32 0.0074 0.0257 0.0257
Loa Loa (eye worm) proteasome subunit beta type 2 0.004 0.0048 0.0048
Echinococcus multilocularis cathepsin L 0.0194 0.0989 0.0989
Echinococcus granulosus cathepsin L 0.0194 0.0989 0.0989
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0039 0.0042 0.0042
Onchocerca volvulus 0.0882 0.5195 0.5189
Giardia lamblia Cysteine protease 0.0194 0.0989 0.296
Loa Loa (eye worm) hypothetical protein 0.0044 0.0069 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Trypanosoma cruzi kinesin, putative 0.0333 0.1837 0.1837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0989 0.1904
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0989 0.1904
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0178 0.0888 1
Plasmodium vivax hypothetical protein, conserved 0.0238 0.1254 0.2415
Echinococcus granulosus Transglutaminase 0.0288 0.1565 0.1565
Loa Loa (eye worm) proteasome subunit beta type 1 0.0065 0.0198 0.0198
Echinococcus granulosus calpain 5 0.0476 0.2712 0.2712
Giardia lamblia Cathepsin B precursor 0.0579 0.3341 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0194 0.0989 0.0989
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0073 0.025 0.025
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0083 0.0083
Brugia malayi Proteasome A-type and B-type family protein 0.0083 0.0312 0.0312
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0194 0.0989 0.1904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Plasmodium falciparum proteasome subunit beta type-2, putative 0.004 0.0048 0.0092
Toxoplasma gondii troponin c, isotype gamma, putative 0.0073 0.025 0.025
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0042 0.006 0.0115
Schistosoma mansoni glycogen phosphorylase 0.0107 0.0453 0.0453
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0139 0.0653 0.1955
Loa Loa (eye worm) cathepsin B 0.0579 0.3341 0.3341
Leishmania major cytochrome p450-like protein 0.0033 0.0004 0.0004
Entamoeba histolytica prolyl oligopeptidase family protein 0.0238 0.1254 0.2415
Schistosoma mansoni microtubule-associated protein tau 0.1421 0.8488 0.8488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.098 0.5794 0.5794
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Onchocerca volvulus 0.0073 0.025 0.0239
Echinococcus multilocularis hypothetical protein 0.0476 0.2712 0.2712
Entamoeba histolytica calcium-binding protein, putative 0.0073 0.025 0.0482
Trypanosoma brucei calmodulin, putative 0.0073 0.025 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0473 0.2694 0.2694
Toxoplasma gondii histone deacetylase HDAC1 0.01 0.0413 0.0413
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.0046
Brugia malayi Papain family cysteine protease containing protein 0.0473 0.2694 0.2694
Mycobacterium ulcerans putative transglutaminase-like protein 0.0288 0.1565 0.3803
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0288 0.1565 0.1831
Brugia malayi prolyl oligopeptidase family protein 0.0238 0.1254 0.1254
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0178 0.0888 0.1808
Plasmodium vivax vivapain-1 0.0473 0.2694 0.5186
Leishmania major oligopeptidase b 0.0706 0.4115 0.4115
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0413 0.0413
Echinococcus granulosus cathepsin l1 0.0882 0.5195 0.5195
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0048 0.0048
Mycobacterium ulcerans hypothetical protein 0.0288 0.1565 0.3803
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.025 0.0482
Trichomonas vaginalis calmodulin, putative 0.0073 0.025 0.0482
Onchocerca volvulus 0.0049 0.0102 0.009
Plasmodium falciparum serine repeat antigen 8 0.0194 0.0989 0.1904
Echinococcus multilocularis expressed protein 0.0778 0.4553 0.4553
Trypanosoma cruzi calmodulin, putative 0.0073 0.025 0.025
Trypanosoma brucei Component of motile flagella 41 0.0073 0.025 0.025
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0042 0.006 0.006
Trypanosoma cruzi centrin-3 0.0073 0.025 0.025
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.004 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0143 0.0677 0.1303
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0143 0.0677 0.0677
Echinococcus granulosus glycogen phosphorylase 0.0107 0.0453 0.0453
Entamoeba histolytica calmodulin, putative 0.0073 0.025 0.0482
Trichomonas vaginalis calcium binding protein, putative 0.0073 0.025 0.0482
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0035 0.0016 0.0016
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0677 0.0677
Echinococcus granulosus calmodulin 0.0073 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0046 0.0046
Leishmania major phospholipase c-like protein 0.0073 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.1439 0.8594 0.8594
Trypanosoma brucei histone deacetylase 2 0.0043 0.0064 0.0064
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0178 0.0888 0.2159
Schistosoma mansoni cathepsin F (C01 family) 0.0603 0.349 0.349
Trypanosoma cruzi 20S proteasome subunit 0.004 0.0048 0.0048
Brugia malayi Cathepsin L-like precursor 0.0279 0.1507 0.1507
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0042 0.006 0.0115

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.56 uM In vitro inhibition of human ovarian cell line, resistant to doxorubicin (CH1doxR). ChEMBL. 10447962
IC50 (functional) = 1.55 uM In vitro inhibition of human ovarian cell line (CH1) ChEMBL. 10447962
IC50 (functional) = 2.05 uM In vitro inhibition of human ovarian cell line, resistant to cisplatin (CH1cisR). ChEMBL. 10447962
IC50 (functional) = 3.1 uM In vitro inhibition of human ovarian cell line SKOV-3. ChEMBL. 10447962
IC50 (functional) = 9.6 uM In vitro inhibition of human ovarian cell line, resistant to cisplatin (A2780cisR). ChEMBL. 10447962
IC50 (functional) > 25 uM In vitro inhibition of human ovarian cell line A2780 ChEMBL. 10447962
Resistance factor (functional) = 0.4 Resistance factor, (IC50 of CH1 doxR / IC50 of CH1) ChEMBL. 10447962
Resistance factor (functional) = 1.3 Resistance factor, (IC50 of CH1 cisR / IC50 of CH1) ChEMBL. 10447962

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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