Detailed information for compound 43255

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 384.426 | Formula: C21H24N2O5
  • H donors: 2 H acceptors: 4 LogP: 2.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1coc(n1)C1C2CCC(C1Cc1ccccc1CCC(=O)O)O2
  • InChi: 1S/C21H24N2O5/c1-22-20(26)15-11-27-21(23-15)19-14(16-7-8-17(19)28-16)10-13-5-3-2-4-12(13)6-9-18(24)25/h2-5,11,14,16-17,19H,6-10H2,1H3,(H,22,26)(H,24,25)
  • InChiKey: XRRNUAXUYMWVSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Onchocerca volvulus Matrix metalloproteinase homolog 0.0053 0.0111 0.0182
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0149 0.0148
Giardia lamblia Pyruvate kinase 0.0033 0.0054 0.0123
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0032 0.0064
Schistosoma mansoni hypothetical protein 0.0059 0.0129 0.0129
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0021 0.0021
Leishmania major pyruvate kinase 0.0033 0.0054 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0141
Chlamydia trachomatis pyruvate kinase 0.0033 0.0054 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0399 0.1113 0.2224
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0821 0.2338 0.2333
Echinococcus granulosus cathepsin l1 0.1741 0.5004 0.5004
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0943 0.269 0.269
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0097 0.0097
Echinococcus granulosus calpain 0.0555 0.1564 0.1564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Schistosoma mansoni calpain-2 (C02 family) 0.0273 0.0748 0.0748
Echinococcus granulosus sex peptide receptor 0.0022 0.0021 0.0021
Brugia malayi neuropeptide F receptor 0.0022 0.0021 0.0021
Schistosoma mansoni dopamine-beta-monooxygenase 0.012 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0251 0.0683 0.0683
Plasmodium vivax centrin-1, putative 0.0059 0.0129 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0399 0.1113 0.2215
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0064 0.0058
Trypanosoma cruzi unspecified product 0.0363 0.101 0.1004
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0015 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0399 0.1113 0.2215
Schistosoma mansoni hypothetical protein 0.0342 0.0947 0.0947
Brugia malayi larval opioid receptor 0.0022 0.0021 0.0021
Brugia malayi neuropeptide F receptor 0.0022 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.0567 0.0562
Echinococcus granulosus calpain A 0.0555 0.1564 0.1564
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Brugia malayi Cathepsin L-like cysteine proteinase 0.1197 0.3426 0.3426
Echinococcus multilocularis pyruvate kinase 0.0033 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Leishmania major hypothetical protein, conserved 0.0037 0.0064 0.0107
Toxoplasma gondii EFHC1, putative 0.0059 0.0129 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0943 0.269 0.5371
Giardia lamblia Cathepsin B precursor 0.1347 0.3861 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0267 0.0731 0.134
Trichomonas vaginalis calcium binding protein, putative 0.0059 0.0129 0.0246
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0149 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0129 0.0246
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0312 0.4845
Loa Loa (eye worm) hypothetical protein 0.1197 0.3426 0.3426
Brugia malayi MH2 domain containing protein 0.0129 0.0331 0.0331
Brugia malayi Cathepsin L-like precursor 0.1741 0.5004 0.5004
Toxoplasma gondii hypothetical protein 0.0273 0.0748 0.1484
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3466 1 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0009
Trypanosoma cruzi major cysteine proteinase, putative 0.0399 0.1113 0.1107
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0024 0.002
Trypanosoma brucei Calpain-like protein 2 0.0611 0.1729 0.3187
Leishmania major centrin, putative 0.0059 0.0129 0.0227
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0059 0.0129 0.0123
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0555 0.1567 0.1562
Toxoplasma gondii cathepsin CPL 0.1741 0.5004 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0064 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0021 0.0021
Onchocerca volvulus Cathepsin L homolog 0.1741 0.5004 1
Schistosoma mansoni neuropeptide receptor 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.012 0.0304 0.0304
Trichomonas vaginalis calpain, putative 0.0273 0.0748 0.1484
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0225 0.061 0.061
Giardia lamblia Cathepsin B precursor 0.0399 0.1113 0.2871
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0399 0.1113 0.2224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0015 0.0015
Echinococcus granulosus pyruvate kinase 0.0017 0.0007 0.0007
Onchocerca volvulus 0.0037 0.0064 0.0086
Echinococcus multilocularis calmodulin 0.0059 0.0129 0.0129
Plasmodium vivax vivapain-3 0.0943 0.269 0.5376
Entamoeba histolytica grainin 2 0.0067 0.0153 0.0277
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0021 0.0021
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0828 0.2357 0.4348
Leishmania major receptor-type adenylate cyclase a-like protein 0.021 0.0567 0.1038
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0059 0.0129 0.0229
Plasmodium falciparum serine repeat antigen 9 0.0399 0.1113 0.2215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Schistosoma mansoni calmodulin 0.0059 0.0129 0.0129
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.063 0.1782 0.1777
Schistosoma mansoni centrin-related 0.0059 0.0129 0.0129
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0483 0.1358 0.1352
Schistosoma mansoni reticulocalbin 0.0059 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0032 0.0026
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0483 0.1358 0.1352
Entamoeba histolytica cysteine protease, putative 0.1741 0.5004 1
Brugia malayi putative neuropeptide receptor 0.0022 0.0021 0.0021
Echinococcus multilocularis programmed cell death protein 0.0067 0.0153 0.0153
Trypanosoma cruzi major cysteine proteinase, putative 0.054 0.1522 0.1517
Trypanosoma cruzi cysteine peptidase, putative 0.1741 0.5004 0.5001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0054 0.0053
Brugia malayi GnHR receptor homolog 0.0022 0.0021 0.0021
Schistosoma mansoni cathepsin B (C01 family) 0.0399 0.1113 0.1113
Loa Loa (eye worm) RNA binding protein 0.0066 0.0149 0.0148
Schistosoma mansoni pyruvate kinase 0.0033 0.0054 0.0054
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0061 0.0133 0.0133
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0399 0.1113 0.2215
Trypanosoma brucei calpain, putative 0.0273 0.0748 0.1372
Brugia malayi Papain family cysteine protease containing protein 0.0399 0.1113 0.1113
Trypanosoma cruzi cysteine peptidase, putative 0.1883 0.5413 0.541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0027
Trypanosoma brucei centrin-3 0.0067 0.0153 0.0272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0236 0.0236
Brugia malayi EF hand family protein 0.0059 0.0129 0.0129
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0399 0.1113 0.2224
Trichomonas vaginalis calmodulin, putative 0.0061 0.0133 0.0254
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0064 0.0918
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0037 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0021 0.0021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.063 0.1782 0.3284
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0273 0.0748 0.1484
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.033 0.033
Trypanosoma brucei calpain-like protein, putative 0.0555 0.1564 0.2882
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.009 0.0084
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0064 1
Leishmania major programmed cell death 6 protein-like protein 0.0059 0.0129 0.0227
Trichomonas vaginalis centrin, putative 0.0059 0.0129 0.0246
Entamoeba histolytica cysteine protease, putative 0.0399 0.1113 0.2201
Brugia malayi Cathepsin L-like precursor 0.1197 0.3426 0.3426
Toxoplasma gondii cathepsin CPC1 0.0399 0.1113 0.2215
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Echinococcus granulosus EF hand domain containing family member A2 0.0059 0.0129 0.0129
Entamoeba histolytica cysteine proteinase, putative 0.0943 0.269 0.5363
Loa Loa (eye worm) fibroinase 0.1741 0.5004 0.5003
Schistosoma mansoni cathepsin s 0.0544 0.1535 0.1535
Echinococcus granulosus calcium uptake protein 1 0.0061 0.0133 0.0133
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0061 0.0133 0.0133
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.1945 0.1945
Leishmania major DNA polymerase kappa, putative 0.002 0.0015 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0236 0.0236
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0141 0.0141
Giardia lamblia Cathepsin L precursor 0.0399 0.1113 0.2871
Toxoplasma gondii troponin c, isotype gamma, putative 0.0059 0.0129 0.0246
Leishmania major calmodulin, putative 0.0059 0.0129 0.0227
Echinococcus multilocularis calpain 0.0555 0.1564 0.1564
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0015 0.1485
Plasmodium vivax glutathione reductase, putative 0.0048 0.0097 0.0194
Trypanosoma brucei unspecified product 0.002 0.0015 0.0016
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0064 0.0064
Leishmania major hypothetical protein, conserved 0.0059 0.0129 0.0227
Brugia malayi calcium-binding protein 0.0059 0.0129 0.0129
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0064 0.0918
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0064 0.0116
Leishmania major pyruvate kinase 0.0033 0.0054 0.0088
Brugia malayi Hemopexin family protein 0.0034 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Entamoeba histolytica protein kinase, putative 0.0282 0.0774 0.1522
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0021 0.0021
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0024 0.0027 0.0027
Brugia malayi Papain family cysteine protease containing protein 0.0943 0.269 0.269
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0021 0.0021
Brugia malayi intermediate filament protein 0.0028 0.0037 0.0037
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0097 0.1446
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0064
Trypanosoma brucei conserved protein 0.022 0.0594 0.1087
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0021 0.0021
Brugia malayi Papain family cysteine protease containing protein 0.0399 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0021 0.0021
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0141 0.0141
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0032 0.0052
Trypanosoma cruzi I/6 autoantigen, putative 0.0059 0.0129 0.0123
Echinococcus granulosus lamin 0.0028 0.0037 0.0037
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0277 0.4282
Echinococcus granulosus dna polymerase kappa 0.002 0.0015 0.0015
Brugia malayi ORL1-like opioid receptor 0.0022 0.0021 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0064 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0037 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0572 0.1616 0.1611
Trichomonas vaginalis set domain proteins, putative 0.0503 0.1414 0.2817
Schistosoma mansoni mitochondrial solute carrier 0.0059 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0855 0.2434 0.2434
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0061 0.0133 0.0127
Leishmania major calmodulin-like protein 0.0059 0.0129 0.0227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0006 0.5
Brugia malayi Cathepsin L-like precursor 0.1741 0.5004 0.5004
Leishmania major cathepsin L-like protease 0.1883 0.5413 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0399 0.1113 0.1113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0021 0.0021
Plasmodium vivax unspecified product 0.0943 0.269 0.5376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Toxoplasma gondii centrin, putative 0.0059 0.0129 0.0246
Plasmodium falciparum serine repeat antigen 4 0.0399 0.1113 0.2215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0027
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0009
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0399 0.1113 0.2215
Plasmodium falciparum serine repeat antigen 3 0.0399 0.1113 0.2215
Schistosoma mansoni Mername-AA248 (C02 family) 0.0555 0.1564 0.1564
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0399 0.1113 0.2224
Brugia malayi hypothetical protein 0.0251 0.0683 0.0683
Schistosoma mansoni calpain (C02 family) 0.0555 0.1564 0.1564
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0483 0.1358 0.1352
Trypanosoma cruzi centrin, putative 0.0067 0.0153 0.0147
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0021 0.0021
Brugia malayi calpain D 0.0273 0.0748 0.0748
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0225 0.061 0.061
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0273 0.0748 0.1372
Plasmodium vivax serine-repeat antigen (SERA) 0.0399 0.1113 0.2224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0027
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.1197 0.3426 0.3426
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0747 0.2122 0.3913
Brugia malayi Protein kinase domain containing protein 0.0022 0.0021 0.0021
Leishmania major protein kinase, putative 0.0059 0.0129 0.0227
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.0037 0.0064 0.0918
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0821 0.2338 0.4312
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0399 0.1113 0.1113
Trypanosoma cruzi small myristoylated protein 1-1 0.0363 0.101 0.1004
Loa Loa (eye worm) hypothetical protein 0.0399 0.1113 0.1113
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0015 0.0016
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1187 0.3396 0.3396
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0267 0.0731 0.134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0236 0.0236
Onchocerca volvulus 0.0059 0.0129 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0399 0.1113 0.2215
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0021 0.0021
Brugia malayi Cathepsin L-like precursor 0.1741 0.5004 0.5004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Brugia malayi Cathepsin L-like precursor 0.1741 0.5004 0.5004
Echinococcus granulosus pyruvate kinase 0.0033 0.0054 0.0054
Echinococcus multilocularis cathepsin L 0.0943 0.269 0.269
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0597 0.1687 0.1682
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0401 0.1119 0.1114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0399 0.1113 0.2215
Schistosoma mansoni lamin 0.0028 0.0037 0.0037
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0828 0.2357 0.4348
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0724 0.2055 0.379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Onchocerca volvulus Matrilysin homolog 0.0024 0.0027 0.0012
Trypanosoma cruzi calmodulin, putative 0.0059 0.0129 0.0123
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0059 0.0129 0.0129
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0064 1
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0021 0.0021
Giardia lamblia DINP protein human, muc B family 0.002 0.0015 0.0022
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0784 0.2229 0.4112
Leishmania major cathepsin L-like protease 0.1883 0.5413 1
Giardia lamblia Cathepsin L precursor 0.0399 0.1113 0.2871
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Schistosoma mansoni cathepsin S (C01 family) 0.0399 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Leishmania major calpain protease-like protein 0.0273 0.0748 0.1372
Leishmania major hypothetical protein, conserved 0.021 0.0567 0.1038
Brugia malayi Calmodulin-like protein 0.0059 0.0129 0.0129
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0059 0.0129 0.0129
Onchocerca volvulus Cathepsin L homolog 0.0399 0.1113 0.2191
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0399 0.1113 0.1113
Schistosoma mansoni neuronal calcium sensor 0.0059 0.0129 0.0129
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1741 0.5004 0.5004
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0399 0.1113 0.2215
Leishmania major cathepsin L-like protease 0.1741 0.5004 0.9243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Leishmania major hypothetical protein, conserved 0.021 0.0567 0.1038
Brugia malayi Cathepsin L-like precursor 0.1197 0.3426 0.3426
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0021 0.0021
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi centrin-3 0.0067 0.0153 0.0147
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0021 0.0021
Trichomonas vaginalis calcium binding protein, putative 0.0067 0.0153 0.0294
Giardia lamblia Cysteine protease 0.0399 0.1113 0.2871
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.0567 0.0562
Trichomonas vaginalis calpain, putative 0.0273 0.0748 0.1484
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0149 0.0149
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.1945 0.1945
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0054 0.0424
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0015 0.0015
Leishmania major hypothetical protein, unknown function 0.0273 0.0748 0.1372
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Toxoplasma gondii thioredoxin reductase 0.0048 0.0097 0.0183
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0225 0.061 0.061
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0064 0.0116
Trypanosoma brucei calpain, putative 0.0539 0.1521 0.2802
Entamoeba histolytica calmodulin, putative 0.0059 0.0129 0.0229
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0399 0.1113 0.2215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0021 0.0021
Plasmodium falciparum serine repeat antigen 1 0.0399 0.1113 0.2215
Loa Loa (eye worm) glutathione reductase 0.0048 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0324 0.0897 0.0897
Onchocerca volvulus 0.1197 0.3426 0.6834
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1347 0.3861 0.3861
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0483 0.1358 0.1352
Loa Loa (eye worm) EF hand family protein 0.0059 0.0129 0.0129
Brugia malayi Matrixin family protein 0.0024 0.0027 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0399 0.1113 0.1113
Leishmania major kinesin, putative 0.0282 0.0774 0.1421
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Onchocerca volvulus 0.1741 0.5004 1
Giardia lamblia Cathepsin L precursor 0.0399 0.1113 0.2871
Brugia malayi Matrixin family protein 0.0024 0.0027 0.0027
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0021 0.0042
Schistosoma mansoni amine GPCR 0.0022 0.0021 0.0021
Leishmania major centrin, putative 0.0059 0.0129 0.0227
Brugia malayi programmed cell death protein 6 0.0059 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0016
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0273 0.0748 0.1484
Brugia malayi Dopamine receptor protein 1 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0277 0.4282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Loa Loa (eye worm) hypothetical protein 0.0399 0.1113 0.1113
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Trichomonas vaginalis conserved hypothetical protein 0.0399 0.1113 0.2215
Schistosoma mansoni opsin-like receptor 0.0022 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.021 0.0567 0.0562
Leishmania major hypothetical protein, conserved 0.0022 0.0021 0.0028
Echinococcus granulosus allatostatin A receptor 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0021 0.0021
Treponema pallidum NADH oxidase 0.0017 0.0006 0.5
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0544 0.1535 0.1535
Trypanosoma brucei antigen, putative 0.0555 0.1564 0.2882
Leishmania major cathepsin L-like protease 0.1741 0.5004 0.9243
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0573 0.1617 0.1617
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0059 0.0129 0.0123
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0006 0.0012
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0021 0.0021
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0021 0.0021
Trichomonas vaginalis calmodulin, putative 0.0059 0.0129 0.0246
Plasmodium falciparum pyruvate kinase 0.0033 0.0054 0.0095
Loa Loa (eye worm) hypothetical protein 0.3466 1 1
Onchocerca volvulus 0.0573 0.1617 0.3204
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0539 0.1521 0.2802
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0821 0.2338 0.4312
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0021 0.0021
Echinococcus multilocularis sex peptide receptor 0.0022 0.0021 0.0021
Plasmodium vivax unspecified product 0.0544 0.1535 0.3067
Entamoeba histolytica cysteine protease, putative 0.0399 0.1113 0.2201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0399 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0273 0.0748 0.1484
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0784 0.2229 0.4112
Schistosoma mansoni hypothetical protein 0.0129 0.033 0.033
Echinococcus granulosus cathepsin b 0.3466 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0492 0.1384 0.2548
Trypanosoma cruzi centrin, putative 0.0067 0.0153 0.0147
Schistosoma mansoni thyroid hormone receptor 0.0139 0.036 0.036
Trypanosoma cruzi conserved protein 0.0492 0.1384 0.1379
Loa Loa (eye worm) hypothetical protein 0.0399 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0399 0.1113 0.2215
Trypanosoma brucei mitochondrial calcium uptake 1 0.0059 0.0129 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Schistosoma mansoni calpain-7 (C02 family) 0.0555 0.1564 0.1564
Trypanosoma cruzi kinesin, putative 0.0282 0.0774 0.0769
Echinococcus granulosus pyruvate kinase 0.0017 0.0007 0.0007
Trichomonas vaginalis calmodulin-2, putative 0.0059 0.0129 0.0246
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0021 0.0021
Onchocerca volvulus Cathepsin L homolog 0.1741 0.5004 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0021 0.0021
Trichomonas vaginalis calmodulin, putative 0.0059 0.0129 0.0246
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0021 0.0021
Onchocerca volvulus 0.0063 0.0141 0.0241
Leishmania major small myristoylated protein-3, putative 0.0308 0.0849 0.1559
Mycobacterium leprae Probable lipase LipE 0.0037 0.0064 0.0814
Giardia lamblia Cathepsin L precursor 0.0399 0.1113 0.2871
Entamoeba histolytica hypothetical protein 0.0399 0.1113 0.2201
Brugia malayi Matrixin family protein 0.0024 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1741 0.5004 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0034 0.0056 0.0056
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0021 0.0021
Echinococcus granulosus centrin 2 0.0059 0.0129 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0943 0.269 0.4964
Plasmodium falciparum cysteine proteinase falcipain 1 0.0943 0.269 0.5371
Brugia malayi G-protein coupled receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0009
Brugia malayi Matrixin family protein 0.0024 0.0027 0.0027
Brugia malayi calpain 7 0.0555 0.1564 0.1564
Trypanosoma brucei kinesin, putative 0.0282 0.0774 0.1421
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0544 0.1535 0.1535
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3466 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Leishmania major trypanothione reductase 0.0048 0.0097 0.0169
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0312 0.4845
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0399 0.1113 0.1113
Echinococcus multilocularis EF hand domain containing family member A2 0.0061 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0273 0.0748 0.0748
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0021 0.0021
Entamoeba histolytica calmodulin, putative 0.0059 0.0129 0.0229
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0236 0.0236
Trypanosoma brucei cysteine peptidase, putative 0.0483 0.1358 0.25
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0544 0.1535 0.1535
Giardia lamblia Cysteine protease 0.0399 0.1113 0.2871
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0021 0.0021
Leishmania major small myristoylated protein-2 0.0662 0.1875 0.3457
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0021 0.0021
Leishmania major DNA polymerase eta, putative 0.0046 0.009 0.0155
Echinococcus granulosus cysteine protease 0.0943 0.269 0.269
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Entamoeba histolytica calpain large subunit domain III containing protein 0.0282 0.0774 0.1522
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0483 0.1358 0.1352
Giardia lamblia Cathepsin B precursor 0.1347 0.3861 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0064 0.0128
Toxoplasma gondii EF hand domain-containing protein 0.0059 0.0129 0.0246
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0054 0.0752
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0106 0.0106
Loa Loa (eye worm) matrixin family protein 0.0058 0.0125 0.0125
Trichomonas vaginalis esterase, putative 0.0037 0.0064 0.0116
Brugia malayi fibroinase precursor 0.0399 0.1113 0.1113
Onchocerca volvulus 0.1741 0.5004 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1338 0.3835 0.3832
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0141 0.0141
Echinococcus multilocularis calpain 5 0.0555 0.1564 0.1564
Onchocerca volvulus 0.0037 0.0064 0.0086
Brugia malayi Cathepsin L-like precursor 0.1741 0.5004 0.5004
Toxoplasma gondii preprocathepsin c precursor, putative 0.0399 0.1113 0.2215
Trypanosoma brucei Calpain-like protein 1.2 0.063 0.1782 0.3284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1347 0.3861 0.7715
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0149 0.0149
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0021 0.0021
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0021 0.0021
Brugia malayi Cathepsin L-like precursor 0.0544 0.1535 0.1535
Brugia malayi calpain 5 0.0282 0.0774 0.0774
Loa Loa (eye worm) cathepsin B 0.1347 0.3861 0.3861
Entamoeba histolytica calcium binding family protein 0.0059 0.0129 0.0229
Schistosoma mansoni opsin-like receptor 0.0022 0.0021 0.0021
Schistosoma mansoni calpain C (C02 family) 0.0555 0.1564 0.1564
Schistosoma mansoni cathepsin C 0.0399 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0061 0.0133 0.0235
Trypanosoma brucei Component of motile flagella 41 0.0059 0.0129 0.0227
Echinococcus granulosus cathepsin l1 0.1197 0.3426 0.3426
Loa Loa (eye worm) calpain family protein 1 0.0846 0.2408 0.2407
Plasmodium falciparum serine repeat antigen 2 0.0399 0.1113 0.2215
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0021 0.0015
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0943 0.269 0.5363
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.0639 1
Leishmania major centrin, putative,caltractin, putative 0.0059 0.0129 0.0227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma brucei small myristoylated protein 1-1 0.0363 0.101 0.1856
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.0133 0.0237
Echinococcus multilocularis pyruvate kinase 0.0026 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0341 0.0946 0.094
Toxoplasma gondii cathepsin B 0.1347 0.3861 0.7715
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0064 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Echinococcus granulosus g protein coupled receptor 0.0022 0.0021 0.0021
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0021 0.0021
Echinococcus granulosus orexin receptor type 2 0.0022 0.0021 0.0021
Echinococcus multilocularis pyruvate kinase 0.0017 0.0007 0.0007
Brugia malayi Pre-SET motif family protein 0.0442 0.1237 0.1237
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0007 0.0013
Echinococcus granulosus tar DNA binding protein 0.0066 0.0149 0.0149
Echinococcus multilocularis cathepsin L cysteine protease 0.1741 0.5004 0.5004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0021 0.0021
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.021 0.0567 0.0562
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0597 0.1687 0.3109
Onchocerca volvulus 0.0051 0.0106 0.0169
Giardia lamblia Cathepsin L-like protease 0.0399 0.1113 0.2871
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0225 0.061 0.061
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0273 0.0748 0.1484
Giardia lamblia Cathepsin L precursor 0.0399 0.1113 0.2871
Schistosoma mansoni adenoreceptor 0.0022 0.0021 0.0021
Echinococcus granulosus calpain 5 0.0555 0.1564 0.1564
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0064 0.0064
Schistosoma mansoni calpain-7 (C02 family) 0.0555 0.1564 0.1564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0399 0.1113 0.2215
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0273 0.0748 0.1484
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0399 0.1113 0.2224
Schistosoma mansoni amine GPCR 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0399 0.1113 0.2215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0465 0.1305 0.2403
Trypanosoma brucei hypothetical protein 0.0539 0.1521 0.2802
Onchocerca volvulus 0.1741 0.5004 1
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0059 0.0129 0.0129
Loa Loa (eye worm) calpain D 0.0273 0.0748 0.0747
Loa Loa (eye worm) hypothetical protein 0.1741 0.5004 0.5003
Echinococcus multilocularis lamin 0.0028 0.0037 0.0037
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0021 0.0021
Loa Loa (eye worm) calpain 5 0.0282 0.0774 0.0774
Entamoeba histolytica cysteine protease, putative 0.0399 0.1113 0.2201
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0021 0.0021
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0483 0.1358 0.25
Schistosoma mansoni intermediate filament proteins 0.0028 0.0037 0.0037
Echinococcus multilocularis calpain 7 (C02 family) 0.0555 0.1564 0.1564
Brugia malayi Papain family cysteine protease containing protein 0.0943 0.269 0.269
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0054 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0267 0.0731 0.134
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis serotonin receptor 0.0022 0.0021 0.0021
Giardia lamblia Cysteine protease 0.0399 0.1113 0.2871
Giardia lamblia Cathepsin B precursor 0.0399 0.1113 0.2871
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Echinococcus granulosus EF hand domain containing family member A2 0.0061 0.0133 0.0133
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0267 0.0731 0.0725
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0273 0.0748 0.1484
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0821 0.2338 0.2333
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0821 0.2338 0.4312
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.009 0.0155
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0273 0.0748 0.0747
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0021 0.0021
Plasmodium vivax SET domain protein, putative 0.0063 0.0141 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.021 0.0567 0.1038
Trypanosoma cruzi cruzipain precursor, putative 0.1883 0.5413 0.541
Echinococcus multilocularis hypothetical protein 0.0555 0.1564 0.1564
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0064 0.0107
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0059 0.0129 0.0257
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0021 0.0021
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0059 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Trichomonas vaginalis calcium binding protein, putative 0.0059 0.0129 0.0246
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1187 0.3396 0.3396
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0097 0.0097
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0021 0.0021
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1741 0.5004 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0021 0.0021
Leishmania major META domain containing protein 0.021 0.0567 0.1038
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0021 0.0021
Echinococcus granulosus cathepsin L 0.0943 0.269 0.269
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0021 0.0021
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0399 0.1113 0.2224
Trypanosoma brucei Calpain-like protein CALP1.3 0.0483 0.1358 0.25
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0021 0.0021
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0399 0.1113 0.2871
Entamoeba histolytica cysteine protease, putative 0.0399 0.1113 0.2201
Brugia malayi G-protein coupled receptor 0.0022 0.0021 0.0021
Giardia lamblia Hypothetical protein 0.0399 0.1113 0.2871
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0399 0.1113 0.1113
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Schistosoma mansoni biogenic amine receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi cruzipain precursor, putative 0.0544 0.1535 0.153
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0021 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0021 0.0021
Trypanosoma brucei calpain-like protein, putative 0.0555 0.1564 0.2882
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0399 0.1113 0.2215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0943 0.269 0.4964
Brugia malayi cathepsin L-like cysteine proteinase 0.0399 0.1113 0.1113
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0943 0.269 0.269
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0015 0.0015
Echinococcus multilocularis cathepsin L 0.0399 0.1113 0.1113
Brugia malayi cathepsin L-like precursor 0.1197 0.3426 0.3426
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0054 0.0054
Brugia malayi Pre-SET motif family protein 0.0063 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0399 0.1113 0.2215
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0267 0.0731 0.134
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.012 0.0304 0.0304
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0021 0.0021
Brugia malayi cathepsin Z-like cysteine proteinase 0.0399 0.1113 0.1113
Entamoeba histolytica cysteine proteinase, putative 0.0943 0.269 0.5363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0064
Toxoplasma gondii calcium-dependent protein kinase 0.0061 0.0133 0.0254
Loa Loa (eye worm) hypothetical protein 0.1127 0.3224 0.3224
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.033 0.033
Trypanosoma cruzi cysteine peptidase, putative 0.0544 0.1535 0.153
Trichomonas vaginalis hypothetical protein 0.0273 0.0748 0.1484
Schistosoma mansoni lamin 0.0028 0.0037 0.0037
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0465 0.1305 0.13
Plasmodium falciparum serine repeat antigen 8 0.0399 0.1113 0.2215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Schistosoma mansoni amine GPCR 0.0022 0.0021 0.0021
Schistosoma mansoni peptidylglycine monooxygenase 0.012 0.0304 0.0304
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0555 0.1564 0.2882
Mycobacterium tuberculosis Conserved protein 0.0037 0.0064 0.0918
Echinococcus multilocularis programmed cell death protein 0.0067 0.0153 0.0153
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0483 0.1358 0.25
Trichomonas vaginalis calmodulin, putative 0.0059 0.0129 0.0246
Onchocerca volvulus 0.0028 0.0037 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0064 0.0064
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0539 0.1521 0.2802
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0064 0.0918
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0308 0.0849 0.0843
Loa Loa (eye worm) ctsf protein 0.1741 0.5004 0.5003
Echinococcus granulosus calmodulin 0.0059 0.0129 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Loa Loa (eye worm) programmed cell death protein 6 0.0061 0.0133 0.0133
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0064 0.0918
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0006 0.0012
Leishmania major small myristoylated protein-1 0.0363 0.101 0.1856
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0483 0.1358 0.1352
Plasmodium falciparum calpain 0.0273 0.0748 0.1484
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0006 0.5
Trichomonas vaginalis calmodulin, putative 0.0059 0.0129 0.0246
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Echinococcus granulosus dna polymerase eta 0.0046 0.009 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0149 0.0149
Loa Loa (eye worm) calmodulin-like protein 0.0059 0.0129 0.0129
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0021 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0064 0.0918
Giardia lamblia Cathepsin B precursor 0.0399 0.1113 0.2871
Echinococcus multilocularis calbindin 32 0.0061 0.0133 0.0133
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0087 0.021 0.021
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.021 0.0567 0.1038
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1347 0.3861 0.7131
Schistosoma mansoni survival motor neuron protein 0.0051 0.0106 0.0106
Entamoeba histolytica cysteine proteinase, putative 0.1197 0.3426 0.6838
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi I/6 autoantigen, putative 0.0059 0.0129 0.0123
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0747 0.2122 0.2117
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0021 0.0021
Brugia malayi Serotonin receptor 0.0022 0.0021 0.0021
Toxoplasma gondii centrin 0.0059 0.0129 0.0246
Echinococcus granulosus hypothetical protein 0.0022 0.0021 0.0021
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0943 0.269 0.269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Onchocerca volvulus Cathepsin F homolog 0.1741 0.5004 1
Trypanosoma brucei calmodulin, putative 0.0061 0.0133 0.0235
Brugia malayi cathepsin F-like cysteine proteinase 0.0544 0.1535 0.1535
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0236 0.0236
Brugia malayi RE15519p 0.0022 0.0021 0.0021
Brugia malayi RNA binding protein 0.0066 0.0149 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0149 0.0149
Leishmania major calmodulin, putative 0.0059 0.0129 0.0227
Schistosoma mansoni hypothetical protein 0.0053 0.0111 0.0111
Plasmodium vivax calpain, putative 0.0555 0.1564 0.3126
Onchocerca volvulus 0.0037 0.0064 0.0086
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0064 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0465 0.1305 0.2403
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0465 0.1305 0.13
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi calmodulin, putative 0.0059 0.0129 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0064 0.0918
Onchocerca volvulus 0.1741 0.5004 1
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.0683 0.0683
Giardia lamblia Cysteine protease 0.0399 0.1113 0.2871
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0029 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0399 0.1113 0.1113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.1237 0.1237
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.021 0.0567 0.1038
Brugia malayi Papain family cysteine protease containing protein 0.1741 0.5004 0.5004
Trichomonas vaginalis calmodulin, putative 0.0059 0.0129 0.0246
Trypanosoma brucei cysteine peptidase C (CPC) 0.1347 0.3861 0.7131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0013 0.0014
Echinococcus granulosus cathepsin b 0.3466 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0024 0.0024
Echinococcus multilocularis dna polymerase eta 0.0046 0.009 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0943 0.269 0.2686
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Plasmodium falciparum serine repeat antigen 7 0.0399 0.1113 0.2215
Leishmania major cathepsin L-like protease 0.1883 0.5413 1
Entamoeba histolytica grainin, putative 0.0061 0.0133 0.0237
Plasmodium falciparum serine repeat antigen 5 0.0399 0.1113 0.2215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.021 0.0567 0.0562
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0021 0.0029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0555 0.1564 0.1559
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Echinococcus granulosus bloom syndrome protein 0.0022 0.0021 0.0021
Leishmania major cathepsin L-like protease 0.1741 0.5004 0.9243
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0054 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.063 0.1782 0.1777
Trichomonas vaginalis calcium binding protein, putative 0.0059 0.0129 0.0246
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0149 0.0149
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0021 0.0021
Schistosoma mansoni biogenic amine receptor 0.0022 0.0021 0.0021
Toxoplasma gondii calmodulin CAM1 0.0061 0.0133 0.0254
Trypanosoma brucei trypanothione reductase 0.0048 0.0097 0.0169
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0399 0.1113 0.2224
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0021 0.0021
Schistosoma mansoni rab 0.0059 0.0129 0.0129
Loa Loa (eye worm) matrix metalloproteinase 0.0024 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0277 0.4282
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Plasmodium vivax vivapain-1 0.0943 0.269 0.5376
Mycobacterium tuberculosis Probable reductase 0.011 0.0277 0.4282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Trypanosoma brucei hypothetical protein, conserved 0.0341 0.0946 0.1738
Loa Loa (eye worm) hypothetical protein 0.0544 0.1535 0.1535
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0015 0.1485
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0021 0.0029
Schistosoma mansoni cathepsin F (C01 family) 0.1197 0.3426 0.3426
Echinococcus multilocularis EF hand domain containing family member A2 0.0059 0.0129 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0064 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Brugia malayi hypothetical protein 0.0124 0.0318 0.0318
Schistosoma mansoni DNA polymerase eta 0.0046 0.009 0.009
Echinococcus multilocularis geminin 0.0342 0.0947 0.0947
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0399 0.1113 0.2201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0064
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0054 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0748 0.1484
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0021 0.0021
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0054 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0139 0.036 0.036
Echinococcus granulosus tachykinin peptides receptor 99D 0.0912 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0399 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma cruzi kinesin, putative 0.0282 0.0774 0.0769
Loa Loa (eye worm) matrixin family protein 0.0053 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0399 0.1113 0.2215
Brugia malayi G protein-coupled receptor 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0141 0.0141
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0021 0.0021
Giardia lamblia Cathepsin B precursor 0.1347 0.3861 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0943 0.269 0.5371
Schistosoma mansoni myosin xvIII 0.0022 0.0021 0.0021
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0021 0.0021
Brugia malayi calpain 5 0.0273 0.0748 0.0748
Onchocerca volvulus 0.1741 0.5004 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1741 0.5004 1
Giardia lamblia Hypothetical protein 0.0061 0.0133 0.033
Plasmodium falciparum serine repeat antigen 6 0.0399 0.1113 0.2215
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0032 0.0052
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0828 0.2357 0.2352
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0097 0.0194
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1187 0.3396 0.3396
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0273 0.0748 0.1372
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0555 0.1564 0.1559
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0054 0.0065
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0331 0.033
Onchocerca volvulus 0.0503 0.1414 0.2796
Trichomonas vaginalis calcineurin B subunit, putative 0.0061 0.0133 0.0254
Echinococcus multilocularis calmodulin 0.0059 0.0129 0.0129
Schistosoma mansoni cathepsin F (C01 family) 0.1741 0.5004 0.5004
Brugia malayi cathepsin F-like cysteine proteinase 0.0399 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0046 0.009 0.009
Plasmodium vivax vivapain-2 0.1741 0.5004 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3466 1 1
Schistosoma mansoni hypothetical protein 0.0342 0.0947 0.0947
Trypanosoma brucei calpain-like protein, putative 0.0555 0.1564 0.2882
Mycobacterium ulcerans beta-lactamase 0.0037 0.0064 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0611 0.1729 0.3187
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0054 0.0088
Echinococcus granulosus neuropeptide receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0308 0.0849 0.0843
Trypanosoma cruzi cysteine peptidase, putative 0.1883 0.5413 0.541
Mycobacterium tuberculosis Conserved protein 0.0037 0.0064 0.0918
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0064 0.0064
Trypanosoma brucei centrin, putative 0.0059 0.0129 0.0227
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.009 0.009
Entamoeba histolytica cysteine protease, putative 0.0399 0.1113 0.2201
Plasmodium vivax unspecified product 0.0399 0.1113 0.2224
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0059 0.0129 0.0123
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0032 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.036 0.036
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0555 0.1564 0.1559
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0483 0.1358 0.25
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0483 0.1358 0.1352
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0175 0.0175
Onchocerca volvulus 0.0399 0.1113 0.2191
Loa Loa (eye worm) cysteine protease 0.1741 0.5004 0.5003
Echinococcus multilocularis musashi 0.0028 0.0037 0.0037
Brugia malayi beta-lactamase family protein 0.0037 0.0064 0.0064
Trichomonas vaginalis calmodulin, putative 0.0059 0.0129 0.0246
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0399 0.1113 0.2871
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0054 0.0095
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Echinococcus multilocularis neuronal calcium sensor 0.0059 0.0129 0.0129
Trypanosoma brucei caltractin, putative 0.0067 0.0153 0.0272
Toxoplasma gondii cathepsin CPC2 0.0399 0.1113 0.2215
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0021 0.0021
Onchocerca volvulus Matrilysin homolog 0.0053 0.0111 0.0182
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0097 0.0092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0026 0.0032 0.0048
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0087 0.021 0.021
Onchocerca volvulus 0.0028 0.0037 0.0033
Echinococcus granulosus g protein coupled receptor 0.0022 0.0021 0.0021
Echinococcus granulosus cathepsin L cysteine proteinase 0.1741 0.5004 0.5004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus granulosus cathepsin L cysteine protease 0.0943 0.269 0.269
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0036
Entamoeba histolytica cysteine proteinase 2 0.0943 0.269 0.5363
Echinococcus multilocularis calpain A 0.1188 0.34 0.34
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0149 0.0149
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0308 0.0849 0.0843
Trypanosoma cruzi cysteine proteinase, putative 0.0943 0.269 0.2686
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0054 0.8186
Echinococcus multilocularis calcium uptake protein 1 0.0061 0.0133 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0054 0.0053
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0021 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0021 0.0021
Brugia malayi Serotonin receptor 0.0022 0.0021 0.0021
Brugia malayi Thioredoxin reductase 0.0048 0.0097 0.0097
Trypanosoma cruzi small myristoylated protein 1-2 0.0363 0.101 0.1004
Echinococcus multilocularis pyruvate kinase 0.0017 0.0007 0.0007
Echinococcus granulosus pyruvate kinase 0.0033 0.0054 0.0054
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0399 0.1113 0.2215
Schistosoma mansoni biogenic amine receptor 0.0022 0.0021 0.0021
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.0567 0.0562
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0064
Brugia malayi calpain family protein 1 0.1127 0.3224 0.3224
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0821 0.2338 0.2333
Plasmodium vivax serine-repeat antigen (SERA) 0.0399 0.1113 0.2224
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0399 0.1113 0.1113
Brugia malayi glutathione reductase 0.0048 0.0097 0.0097
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0021 0.0021
Trypanosoma brucei centrin, putative 0.0059 0.0129 0.0227
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0821 0.2338 0.2333
Leishmania major DNA polymerase eta, putative 0.0032 0.0051 0.0083
Schistosoma mansoni calmodulin related calcium binding protein 0.0059 0.0129 0.0129
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0021 0.0021
Entamoeba histolytica calcium-binding protein, putative 0.0059 0.0129 0.0229
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0021 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0399 0.1113 0.2215
Brugia malayi cathepsin Z-like cysteine proteinase 0.0399 0.1113 0.1113
Onchocerca volvulus 0.1741 0.5004 1
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0054 0.0095
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0015 0.0015
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0129 0.0227
Leishmania major calcineurin B subunit, putative 0.0059 0.0129 0.0227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3466 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0828 0.2357 0.2352
Mycobacterium ulcerans hypothetical protein 0.0037 0.0064 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0029 0.0042 0.057
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.0567 0.0562
Schistosoma mansoni amine GPCR 0.0022 0.0021 0.0021
Leishmania major small myristoylated protein 4, putative 0.0572 0.1616 0.2978
Echinococcus granulosus calumenin 0.0061 0.0133 0.0133
Schistosoma mansoni opsin-like receptor 0.0022 0.0021 0.0021
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0021 0.0031
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0399 0.1113 0.2224
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0399 0.1113 0.2871
Brugia malayi cathepsin L precursor 0.0399 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0399 0.1113 0.1113
Echinococcus multilocularis cathepsin b 0.3466 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0724 0.2055 0.379
Trichomonas vaginalis centrin, putative 0.0059 0.0129 0.0246
Loa Loa (eye worm) hypothetical protein 0.0225 0.061 0.061
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1197 0.3426 0.6844
Echinococcus multilocularis pyruvate kinase 0.0017 0.0007 0.0007
Trypanosoma brucei unspecified product 0.021 0.0567 0.1038
Entamoeba histolytica cysteine proteinase, putative 0.1741 0.5004 1
Trypanosoma cruzi cysteine peptidase, putative 0.1883 0.5413 0.541
Echinococcus multilocularis lamin dm0 0.0028 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0308 0.0849 0.1559
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0021 0.0021
Brugia malayi TAR-binding protein 0.0066 0.0149 0.0149
Trypanosoma brucei small myristoylated protein 1-2 0.0363 0.101 0.1856
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0051 0.0089
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0021 0.0021
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1741 0.5004 0.5003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0037
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0021 0.0021
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0021 0.0021
Brugia malayi AKH receptor 0.0022 0.0021 0.0021
Echinococcus granulosus cathepsin L 0.0399 0.1113 0.1113
Leishmania major cathepsin L-like protease 0.1741 0.5004 0.9243
Echinococcus multilocularis pyruvate kinase 0.0033 0.0054 0.0054
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Echinococcus multilocularis cysteine protease 0.1741 0.5004 0.5004
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.0683 0.0683
Schistosoma mansoni hypothetical protein 0.0051 0.0106 0.0106
Trypanosoma brucei calmodulin, putative 0.0059 0.0129 0.0227
Echinococcus granulosus neuronal calcium sensor 0.0059 0.0129 0.0129
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0399 0.1113 0.1113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0236 0.0236
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0054 0.0107
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0021 0.0021
Loa Loa (eye worm) beta-lactamase 0.0037 0.0064 0.0064
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0059 0.0129 0.0229
Mycobacterium ulcerans hydrolase 0.0029 0.0042 0.6212
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0943 0.269 0.2686
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0912 0.2599 0.2599
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1347 0.3861 0.3858
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.021 0.0567 0.1038
Echinococcus granulosus microtubule associated protein 2 0.0686 0.1945 0.1945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Brugia malayi hypothetical protein 0.0026 0.0032 0.0032
Trypanosoma cruzi caltractin, putative 0.0059 0.0129 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0308 0.0849 0.1559
Schistosoma mansoni amine GPCR 0.0022 0.0021 0.0021
Onchocerca volvulus 0.0059 0.0129 0.0216
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0059 0.0129 0.0129
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0021 0.0031
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0141 0.027
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Plasmodium falciparum centrin-1 0.0059 0.0129 0.0246
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0059 0.0129 0.0227
Entamoeba histolytica cysteine proteinase, putative 0.1741 0.5004 1
Schistosoma mansoni neuropeptide receptor 0.0022 0.0021 0.0021
Leishmania major cysteine peptidase A (CPA) 0.1741 0.5004 0.9243
Brugia malayi calpain family protein 1 0.1127 0.3224 0.3224
Schistosoma mansoni reticulocalbin 0.0061 0.0133 0.0133
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0059 0.0129 0.0246
Schistosoma mansoni neuronal calcium sensor 0.0059 0.0129 0.0129
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0021 0.0021
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0021 0.0021
Echinococcus multilocularis calumenin 0.0061 0.0133 0.0133
Schistosoma mansoni neuronal calcium sensor 0.0059 0.0129 0.0129
Echinococcus granulosus geminin 0.0342 0.0947 0.0947
Plasmodium falciparum thioredoxin reductase 0.0048 0.0097 0.0183
Trichomonas vaginalis calcineurin B subunit, putative 0.0059 0.0129 0.0246
Trypanosoma cruzi cysteine protease, putative 0.0943 0.269 0.2686
Echinococcus multilocularis somatostatin receptor 0.0022 0.0021 0.0021
Trypanosoma brucei I/6 autoantigen 0.0059 0.0129 0.0227
Trypanosoma cruzi cysteine proteinase, putative 0.0943 0.269 0.2686
Plasmodium falciparum cysteine proteinase falcipain 3 0.1741 0.5004 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0037 0.0037
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0399 0.1113 0.1113
Echinococcus multilocularis cathepsin b 0.3466 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0399 0.1113 0.2201
Trypanosoma brucei calpain-like protein, putative 0.0821 0.2338 0.4312
Echinococcus granulosus somatostatin receptor 0.0022 0.0021 0.0021
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.021 0.0567 0.1038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0236 0.0236
Echinococcus granulosus cathepsin l cysteine peptidase 0.1741 0.5004 0.5004
Leishmania major cathepsin L-like protease 0.1741 0.5004 0.9243
Brugia malayi Kringle domain containing protein 0.0022 0.0021 0.0021
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0399 0.1113 0.1113
Entamoeba histolytica cysteine protease, putative 0.0399 0.1113 0.2201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Leishmania major hypothetical protein, conserved 0.021 0.0567 0.1038
Echinococcus multilocularis dna polymerase kappa 0.002 0.0015 0.0015
Echinococcus granulosus serotonin receptor 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0943 0.269 0.5363
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0129 0.0246
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0064
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.021 0.0567 0.1038
Giardia lamblia Cathepsin B precursor 0.0399 0.1113 0.2871
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0021 0.0021
Brugia malayi EF hand family protein 0.0061 0.0133 0.0133
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0015 0.0014
Entamoeba histolytica calpain family cysteine protease, putative 0.0273 0.0748 0.1469
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Brugia malayi Dopamine receptor protein 2 0.0022 0.0021 0.0021
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0064 0.0814
Schistosoma mansoni pyruvate kinase 0.0033 0.0054 0.0054
Echinococcus granulosus calpain 7 C02 family 0.0555 0.1564 0.1564
Plasmodium falciparum glutathione reductase 0.0048 0.0097 0.0183
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0021 0.0021
Toxoplasma gondii ABC1 family protein 0.0037 0.0064 0.0116
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0784 0.2229 0.4112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0141 0.0141
Giardia lamblia Cathepsin L precursor 0.0399 0.1113 0.2871
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0032 0.0052
Trypanosoma brucei protein I/6 0.0059 0.0129 0.0227
Echinococcus granulosus intermediate filament protein 0.0028 0.0037 0.0037
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0828 0.2357 0.4348
Loa Loa (eye worm) hypothetical protein 0.0846 0.2408 0.2407
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0747 0.2122 0.2117
Loa Loa (eye worm) hypothetical protein 0.0544 0.1535 0.1535
Trichomonas vaginalis calmodulin, putative 0.0067 0.0153 0.0294
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0054 0.0088
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0483 0.1358 0.1352
Schistosoma mansoni centrin 0.0059 0.0129 0.0129
Brugia malayi Papain family cysteine protease containing protein 0.0399 0.1113 0.1113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0399 0.1113 0.1113
Echinococcus granulosus EF HAND 1 calcium binding site 0.0059 0.0129 0.0129
Leishmania major i/6 autoantigen-like protein 0.0059 0.0129 0.0227
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0277 0.4282
Echinococcus granulosus fmrfamide receptor 0.0022 0.0021 0.0021
Giardia lamblia Pyruvate kinase 0.0017 0.0007 0.0002
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0059 0.0129 0.0227
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Schistosoma mansoni ef hand domain family member A2 0.0059 0.0129 0.0129
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0597 0.1687 0.1682
Echinococcus granulosus calpain A 0.1188 0.34 0.34
Schistosoma mansoni pyruvate kinase 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0021 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0015 0.0136
Onchocerca volvulus 0.0024 0.0027 0.0012
Onchocerca volvulus 0.0061 0.0133 0.0225
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0007 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0399 0.1113 0.2215
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1741 0.5004 1
Onchocerca volvulus 0.1741 0.5004 1
Trichomonas vaginalis calmodulin, putative 0.0059 0.0129 0.0246
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0021 0.0021
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1741 0.5004 1
Leishmania major phospholipase c-like protein 0.0059 0.0129 0.0227
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0006 0.0006
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0021 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0015 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0097 0.0097
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0134 0.0134
Giardia lamblia Cathepsin B precursor 0.0399 0.1113 0.2871
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1741 0.5004 0.5003
Trypanosoma cruzi calmodulin, putative 0.0059 0.0129 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0064
Leishmania major hypothetical protein, conserved 0.021 0.0567 0.1038
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1127 0.3224 0.3224
Giardia lamblia Cathepsin L-like protease 0.0399 0.1113 0.2871
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0021 0.0021
Echinococcus granulosus calbindin 32 0.0061 0.0133 0.0133
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0021 0.0021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0021 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0236 0.0236
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0312 1
Echinococcus multilocularis centrin 2 0.0059 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0021 0.0021
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0399 0.1113 0.2224
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0331 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0341 0.0946 0.094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0141 0.0141
Echinococcus multilocularis cysteine protease 0.1741 0.5004 0.5004
Echinococcus granulosus neuropeptide receptor 0.0022 0.0021 0.0021
Schistosoma mansoni neuropeptide receptor 0.0022 0.0021 0.0021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0828 0.2357 0.4348
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0059 0.0128 0.0128
Trichomonas vaginalis calcium binding proteins, putative 0.0059 0.0129 0.0246
Onchocerca volvulus 0.0034 0.0056 0.007
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0059 0.0129 0.0123
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0555 0.1564 0.1559
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0875 0.2492 0.2492
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0064 0.0116
Echinococcus granulosus programmed cell death protein 0.0067 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0399 0.1113 0.2215
Trichomonas vaginalis conserved hypothetical protein 0.0341 0.0946 0.188
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.021 0.0567 0.1038
Leishmania major calmodulin-like protein 0.0059 0.0129 0.0227
Schistosoma mansoni histamine h1 receptor 0.0022 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0341 0.0946 0.1738
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0054 0.0048
Loa Loa (eye worm) calpain 0.0555 0.1564 0.1564
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0399 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1197 0.3426 0.6844
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0236 0.0236
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Giardia lamblia Hypothetical protein 0.0399 0.1113 0.2871
Echinococcus granulosus lamin dm0 0.0028 0.0037 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Brugia malayi Melatonin receptor type 1A 0.0022 0.0021 0.0021
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1187 0.3396 0.3396
Schistosoma mansoni calmodulin 0.0059 0.0129 0.0129
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0007 0.0007
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0021 0.0021
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3466 1 1
Trichomonas vaginalis calpain, putative 0.0273 0.0748 0.1484
Leishmania major calpain family cysteine protease-like protein 0.0483 0.1358 0.25
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0277 0.8682
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0021 0.0021
Brugia malayi Dopamine receptor 0.0022 0.0021 0.0021
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0399 0.1113 0.2224
Schistosoma mansoni cathepsin F (C01 family) 0.1741 0.5004 0.5004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0133 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Trypanosoma brucei Calpain-like protein 1.1 0.0828 0.2357 0.4348
Echinococcus granulosus g protein coupled receptor 0.0022 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0007 0.0002
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.021 0.0567 0.1038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1741 0.5004 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0943 0.269 0.5363
Schistosoma mansoni neuronal calcium sensor 0.0059 0.0129 0.0129
Echinococcus multilocularis calpain family protein 1, d 0.0846 0.2408 0.2408
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0267 0.0731 0.134
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0399 0.1113 0.2871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1883 0.5413 1
Loa Loa (eye worm) calpain family protein 1 0.1127 0.3224 0.3224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1741 0.5004 0.5004
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0828 0.2357 0.2352
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0059 0.0129 0.0246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0021 0.0021
Echinococcus multilocularis neurocalcin 0.0059 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus granulosus neurocalcin 0.0059 0.0129 0.0129
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0015 0.0017
Schistosoma mansoni neuropeptide receptor 0.0022 0.0021 0.0021
Giardia lamblia Encystation-specific protease 0.0399 0.1113 0.2871
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0021 0.0021
Loa Loa (eye worm) RecQ helicase 0.0022 0.0021 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0399 0.1113 0.2215
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0277 0.4282
Brugia malayi beta-lactamase 0.0037 0.0064 0.0064
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.021 0.0567 0.1038
Echinococcus multilocularis cathepsin L cysteine protease 0.1741 0.5004 0.5004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0021
Echinococcus multilocularis serotonin receptor 0.0022 0.0021 0.0021
Brugia malayi hypothetical protein 0.0022 0.0021 0.0021
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0059 0.0129 0.0123
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0015 0.0017
Brugia malayi Cathepsin L-like precursor 0.1741 0.5004 0.5004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0399 0.1113 0.2215
Brugia malayi Matrixin family protein 0.0058 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.1197 0.3426 0.3426
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0064 0.0116
Entamoeba histolytica cysteine protease, putative 0.0943 0.269 0.5363
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0312 0.4845
Trichomonas vaginalis myosin light chain 1, putative 0.0059 0.0129 0.0246
Brugia malayi beta-lactamase family protein 0.0037 0.0064 0.0064
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0021 0.0021
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0149 0.0149
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0021 0.0021
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0064 0.0918
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0273 0.0748 0.1484
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0021 0.0021
Brugia malayi sulfakinin receptor protein 0.0022 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0021
Plasmodium vivax vivapain-2 0.1741 0.5004 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0054 0.0048
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0399 0.1113 0.2215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0465 0.1305 0.2403
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0021 0.0021

Activities

Activity type Activity value Assay description Source Reference
I50 (functional) = 20 nM Inhibitory activity against platelet aggregation, induced by arachidonic acid in human platelet rich plasma ChEMBL. 8496908
I50 (functional) = 20 nM Compound was evaluated for the ability to inhibit arachidonic acid induced platelet aggregation (AAIPA) in human platelet rich plasma ChEMBL. No reference
I50 (functional) = 81 nM Inhibitory activity against platelet aggregation, induced by U-46619 in human platelet rich plasma ChEMBL. 8496908
I50 (functional) = 81 nM Compound was evaluated for the ability to inhibit U-46649 induced platelet aggregation (U-IPA) in human platelet rich plasma. ChEMBL. No reference
IC50 (functional) = 20 nM Inhibitory activity against platelet aggregation, induced by arachidonic acid in human platelet rich plasma ChEMBL. 8496908
IC50 (functional) = 20 nM Compound was evaluated for the ability to inhibit arachidonic acid induced platelet aggregation (AAIPA) in human platelet rich plasma ChEMBL. No reference
IC50 (functional) = 81 nM Inhibitory activity against platelet aggregation, induced by U-46619 in human platelet rich plasma ChEMBL. 8496908
IC50 (functional) = 81 nM Compound was evaluated for the ability to inhibit U-46649 induced platelet aggregation (U-IPA) in human platelet rich plasma. ChEMBL. No reference
Kd (binding) = 45 nM Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand ChEMBL. 8496908
Kd (binding) = 45 nM Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand ChEMBL. 8496908
logP (ADMET) = -0.11 Partition coefficient (logP) ChEMBL. 8496908
T50 (ADMET) = 7.5 hr In vivo duration of action required to prevent death in mice, after i.v. administration of U-46619 (0.2 mg/kg) at 0.2 mg/kg p.o. ChEMBL. 8496908
T50 (ADMET) = 7.5 hr In vivo duration of action required to prevent death in mice, after i.v. administration of U-46619 (0.2 mg/kg) at 0.2 mg/kg p.o. ChEMBL. 8496908

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8496908

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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