Detailed information for compound 1460022

Basic information

Technical information
  • TDR Targets ID: 1460022
  • Name: [(4S,6S)-6-(4-hydroxybutoxy)-4-[4-(trifluorom ethyl)phenyl]-5,6-dihydro-4H-pyran-2-yl]-[4-( phenylmethyl)piperazin-1-yl]methanone
  • MW: 518.568 | Formula: C28H33F3N2O4
  • H donors: 1 H acceptors: 2 LogP: 4.52 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCCCO[C@H]1OC(=C[C@H](C1)c1ccc(cc1)C(F)(F)F)C(=O)N1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C28H33F3N2O4/c29-28(30,31)24-10-8-22(9-11-24)23-18-25(37-26(19-23)36-17-5-4-16-34)27(35)33-14-12-32(13-15-33)20-21-6-2-1-3-7-21/h1-3,6-11,18,23,26,34H,4-5,12-17,19-20H2/t23-,26+/m1/s1
  • InChiKey: MYHGUVBHLVZSTN-BVAGGSTKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(4S,6S)-6-(4-hydroxybutoxy)-4-[4-(trifluoromethyl)phenyl]-5,6-dihydro-4H-pyran-2-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone
  • [4-(benzyl)piperazin-1-yl]-[(4S,6S)-6-(4-hydroxybutoxy)-4-[4-(trifluoromethyl)phenyl]-5,6-dihydro-4H-pyran-2-yl]methanone
  • SMR000389639
  • (4-benzylpiperazin-1-yl)((2S,4S)-2-(4-hydroxybutoxy)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyran-6-yl)methanone
  • MLS000766469

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0098 0.022 0.0958
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.1056 0.1056
Giardia lamblia Cysteine protease 0.0194 0.052 0.2031
Trypanosoma cruzi cysteine protease, putative 0.0425 0.1241 0.1743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.052 0.2031
Entamoeba histolytica prolyl oligopeptidase family protein 0.0212 0.0575 0.2502
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Giardia lamblia Hypothetical protein 0.0194 0.052 0.2031
Loa Loa (eye worm) hypothetical protein 0.0068 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.1473 0.4518 0.4518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0533 0.1578 0.6159
Trichomonas vaginalis calmodulin, putative 0.0098 0.022 0.086
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.052 0.2263
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0033 0.0016 0.0028
Trypanosoma cruzi prolyl endopeptidase 0.19 0.5851 0.8219
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0069 0.0097
Plasmodium falciparum plasmepsin I 0.0041 0.004 0.0176
Trichomonas vaginalis esterase, putative 0.0078 0.0158 0.0618
Loa Loa (eye worm) hypothetical protein 0.0092 0.0203 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.0027 0.002
Schistosoma mansoni chromatin regulatory protein sir2 0.0127 0.0312 0.0438
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0069 0.0097
Brugia malayi Animal haem peroxidase family protein 0.0577 0.1716 0.1716
Plasmodium vivax unspecified product 0.0425 0.1241 0.54
Loa Loa (eye worm) hypothetical protein 0.012 0.0289 0.0289
Giardia lamblia Hypothetical protein 0.0072 0.0137 0.0536
Loa Loa (eye worm) CYP4Cod1 0.0072 0.0138 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0212 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0033 0.0047
Brugia malayi Fli-1 protein 0.0461 0.1355 0.1355
Brugia malayi hypothetical protein 0.0045 0.0054 0.0054
Brugia malayi Trypsin-like protease protein 5 0.0082 0.0169 0.0169
Brugia malayi transcriptional regulator, Sir2 family protein 0.0127 0.0312 0.0312
Echinococcus granulosus survival motor neuron protein 1 0.0468 0.1377 0.1934
Schistosoma mansoni chromatin regulatory protein sir2 0.0127 0.0312 0.0438
Leishmania major cathepsin L-like protease 0.0857 0.2591 0.4429
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0016 0.0023
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0194 0.052 0.2263
Echinococcus multilocularis protein jagged 1 0.0053 0.0081 0.0113
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3175
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0764 0.2301 0.3232
Brugia malayi cathepsin L-like precursor 0.0533 0.1578 0.1578
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0298 0.0418
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0075 0.0105
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0069 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.052 0.2031
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.052 0.2031
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0027 0.0045
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0632 0.1887 0.1887
Schistosoma mansoni hypothetical protein 0.0053 0.0081 0.0113
Schistosoma mansoni cathepsin S (C01 family) 0.0194 0.052 0.0731
Mycobacterium ulcerans proteasome PrcB 0.0167 0.0435 0.1641
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0016 0.0063
Schistosoma mansoni caspase-7 (C14 family) 0.0098 0.0221 0.031
Entamoeba histolytica hypothetical protein 0.0038 0.0033 0.0144
Echinococcus granulosus notch 0.0053 0.0081 0.0113
Leishmania major phospholipase c-like protein 0.0098 0.022 0.0376
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0141 0.0354 0.1383
Brugia malayi proteasome subunit beta type 2 0.0051 0.0074 0.0074
Echinococcus granulosus neurogenic locus protein delta 0.0053 0.0081 0.0113
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0033 0.0047
Onchocerca volvulus 0.0577 0.1716 0.2933
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0167 0.0435 0.0611
Brugia malayi cathepsin F-like cysteine proteinase 0.0231 0.0635 0.0635
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0141 0.0354 0.0498
Loa Loa (eye worm) programmed cell death protein 6 0.0099 0.0222 0.0222
Echinococcus granulosus Transglutaminase 0.0072 0.0137 0.0193
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.052 0.052
Schistosoma mansoni mitochondrial solute carrier 0.0098 0.022 0.0309
Trypanosoma brucei calmodulin, putative 0.0098 0.022 0.0376
Schistosoma mansoni cathepsin C 0.0194 0.052 0.0731
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0141 0.0354 0.1383
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0033 0.0033
Entamoeba histolytica cysteine proteinase 1, putative 0.0425 0.1241 0.54
Loa Loa (eye worm) hypothetical protein 0.0194 0.052 0.052
Schistosoma mansoni neuronal calcium sensor 0.0098 0.022 0.0309
Toxoplasma gondii hypothetical protein 0.0212 0.0575 0.0983
Brugia malayi Blistered cuticle protein 3 0.0577 0.1716 0.1716
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0075 0.0105
Echinococcus multilocularis neuronal calcium sensor 0.0098 0.022 0.0309
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0102 0.0102
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0256 0.0715 0.1004
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Trichomonas vaginalis myosin light chain 1, putative 0.0098 0.022 0.086
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0158 0.0158
Trichomonas vaginalis calmodulin-2, putative 0.0098 0.022 0.086
Echinococcus granulosus proteasome prosome macropain 0.0167 0.0435 0.0611
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0276 0.0502
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.0027 0.002
Plasmodium falciparum serine repeat antigen 2 0.0194 0.052 0.2263
Echinococcus granulosus importin subunit beta 1 0.0059 0.0099 0.0138
Brugia malayi Pre-SET motif family protein 0.0092 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Brugia malayi EGF-like domain containing protein 0.0053 0.0081 0.0081
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.022 0.0602 0.0845
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Onchocerca volvulus Putative cubilin 0.0053 0.0081 0.0138
Leishmania major i/6 autoantigen-like protein 0.0098 0.022 0.0376
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0212 0.0575 0.2246
Brugia malayi Cytochrome P450 family protein 0.0134 0.0333 0.0333
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0751 0.226 0.3175
Schistosoma mansoni cathepsin F (C01 family) 0.0763 0.2298 0.3228
Entamoeba histolytica cysteine proteinase, putative 0.0763 0.2298 1
Trypanosoma brucei protein kinase, putative 0.0051 0.0075 0.0127
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0215
Trichomonas vaginalis calmodulin, putative 0.0098 0.022 0.086
Schistosoma mansoni notch 0.0053 0.0081 0.0113
Trichomonas vaginalis centrin, putative 0.0098 0.022 0.086
Giardia lamblia Cathepsin L-like protease 0.0194 0.052 0.2031
Echinococcus multilocularis calpain 7 (C02 family) 0.0751 0.226 0.3175
Echinococcus multilocularis lamin 0.0055 0.0084 0.0118
Entamoeba histolytica cysteine proteinase, putative 0.0425 0.1241 0.54
Echinococcus multilocularis cysteine protease 0.0763 0.2298 0.3228
Echinococcus multilocularis EF hand domain containing family member A2 0.0099 0.0222 0.0311
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0098 0.022 0.0958
Toxoplasma gondii calmodulin CAM1 0.0099 0.0222 0.0379
Giardia lamblia Cathepsin L precursor 0.0194 0.052 0.2031
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.0027 0.0041
Giardia lamblia Transglutaminase/protease, putative 0.0072 0.0137 0.0536
Entamoeba histolytica hypothetical protein 0.0048 0.0064 0.0277
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0127 0.0312 0.0438
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0212 0.0297
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0158 0.0618
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0098 0.0221 0.031
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0074 0.0287
Echinococcus granulosus intermediate filament protein 0.0055 0.0084 0.0118
Leishmania major centrin, putative 0.0098 0.022 0.0376
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0033 0.0047
Echinococcus multilocularis acylamino acid releasing enzyme 0.0212 0.0575 0.0808
Plasmodium falciparum plasmepsin VI 0.0041 0.004 0.0176
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.052 0.2263
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0127 0.0312 0.0533
Trypanosoma brucei SIR2-like protein 4, putative 0.0033 0.0016 0.0028
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0158 0.0557
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0212 0.0575 0.0983
Giardia lamblia Cathepsin B precursor 0.0847 0.2561 1
Brugia malayi Trypsin family protein 0.0082 0.0169 0.0169
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0075 0.0291
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0075 0.0127
Trypanosoma cruzi cruzipain precursor, putative 0.0231 0.0635 0.0891
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0138 0.0138
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0033 0.0033
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0099 0.0168
Schistosoma mansoni centrin-related 0.0098 0.022 0.0309
Brugia malayi Cytochrome P450 family protein 0.0072 0.0138 0.0138
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0194 0.052 0.2263
Leishmania major cathepsin L-like protease 0.0763 0.2298 0.3928
Leishmania major hypothetical protein, conserved 0.0078 0.0158 0.027
Entamoeba histolytica hypothetical protein, conserved 0.0212 0.0575 0.2502
Plasmodium falciparum plasmepsin X 0.0205 0.0555 0.2416
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0016 0.0063
Loa Loa (eye worm) ctsf protein 0.0763 0.2298 0.2298
Toxoplasma gondii exonuclease III APE 0.0076 0.0152 0.0259
Entamoeba histolytica cysteine protease, putative 0.0194 0.052 0.2263
Schistosoma mansoni calpain C (C02 family) 0.0751 0.226 0.3175
Echinococcus granulosus EF hand domain containing family member A2 0.0098 0.022 0.0309
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0553 0.2159
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0215
Echinococcus multilocularis neurogenic locus protein delta 0.0053 0.0081 0.0113
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2103 0.6483 0.9106
Schistosoma mansoni ef hand domain family member A2 0.0098 0.022 0.0309
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Schistosoma mansoni notch 0.0053 0.0081 0.0113
Echinococcus multilocularis programmed cell death protein 0.0102 0.0231 0.0325
Loa Loa (eye worm) notch protein 0.0053 0.0081 0.0081
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2306 0.712 1
Echinococcus granulosus cathepsin L 0.0425 0.1241 0.1743
Schistosoma mansoni laminin gamma-3 chain 0.0053 0.0081 0.0113
Brugia malayi Animal haem peroxidase family protein 0.0577 0.1716 0.1716
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.0199 0.0199
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0058 0.0082
Loa Loa (eye worm) hypothetical protein 0.0108 0.0252 0.0252
Trypanosoma brucei centrin-3 0.0102 0.0231 0.0395
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.052 0.2031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Toxoplasma gondii cathepsin CPC2 0.0194 0.052 0.0889
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0194 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.1253 0.383 0.383
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0588 0.2294
Loa Loa (eye worm) hypothetical protein 0.0151 0.0384 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Loa Loa (eye worm) blistered cuticle protein 3 0.0577 0.1716 0.1716
Loa Loa (eye worm) proteasome subunit beta type 2 0.0051 0.0074 0.0074
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0167 0.0435 0.0809
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.0027 0.002
Leishmania major importin beta-1 subunit, putative 0.0048 0.0064 0.0109
Echinococcus multilocularis caspase 3 0.0072 0.0139 0.0195
Echinococcus granulosus microtubule associated protein 2 0.139 0.4258 0.598
Entamoeba histolytica calcium binding family protein 0.0098 0.022 0.0958
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.052 0.0731
Schistosoma mansoni microtubule-associated protein tau 0.139 0.4258 0.598
Mycobacterium ulcerans hypothetical protein 0.0078 0.0158 0.0557
Trypanosoma brucei Calpain-like protein 2 0.022 0.0602 0.1028
Leishmania major protein kinase, putative 0.0099 0.0222 0.0379
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Leishmania major cytochrome p450-like protein 0.0036 0.0027 0.0045
Echinococcus multilocularis centrin 2 0.0098 0.022 0.0309
Schistosoma mansoni cytochrome P450 0.0036 0.0027 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0751 0.226 0.3175
Trypanosoma cruzi cysteine peptidase, putative 0.0425 0.1241 0.1743
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0041 0.004 0.0057
Schistosoma mansoni peroxidasin 0.0577 0.1716 0.241
Loa Loa (eye worm) hypothetical protein 0.0082 0.0169 0.0169
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.022 0.0602 0.1028
Toxoplasma gondii aspartyl protease ASP3 0.0205 0.0555 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0425 0.1241 0.2121
Entamoeba histolytica cysteine protease, putative 0.0194 0.052 0.2263
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.0152 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.0027 0.002
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1457 0.2046
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0051 0.0074 0.0103
Trypanosoma brucei calpain, putative 0.022 0.0602 0.1028
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0033 0.0129
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0033 0.0047
Loa Loa (eye worm) calpain 0.0751 0.226 0.226
Leishmania major centrin, putative,caltractin, putative 0.0098 0.022 0.0376
Echinococcus multilocularis musashi 0.0055 0.0084 0.0118
Echinococcus multilocularis cathepsin L 0.0425 0.1241 0.1743
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.022 0.0602 0.0845
Schistosoma mansoni notch 0.0053 0.0081 0.0113
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Giardia lamblia Alanyl dipeptidyl peptidase 0.0212 0.0575 0.2246
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0203 0.0285
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0033 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Echinococcus multilocularis tumor protein p63 0.0702 0.2106 0.2958
Schistosoma mansoni hypothetical protein 0.0082 0.0169 0.0238
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0167 0.0435 0.1698
Loa Loa (eye worm) hypothetical protein 0.0091 0.0199 0.0199
Echinococcus multilocularis geminin 0.0205 0.0553 0.0777
Loa Loa (eye worm) hypothetical protein 0.022 0.0602 0.0602
Onchocerca volvulus 0.0045 0.0055 0.0094
Schistosoma mansoni cathepsin D (A01 family) 0.0233 0.0641 0.0901
Schistosoma mansoni cpg binding protein 0.0061 0.0105 0.0147
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0075 0.0105
Brugia malayi Cytochrome P450 family protein 0.0036 0.0027 0.0027
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0075 0.0291
Onchocerca volvulus 0.0763 0.2298 0.3928
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0553 0.2159
Loa Loa (eye worm) calpain family protein 1 0.1473 0.4518 0.4518
Trypanosoma brucei cysteine peptidase C (CPC) 0.0847 0.2561 0.4377
Entamoeba histolytica cysteine proteinase, putative 0.0763 0.2298 1
Mycobacterium tuberculosis Conserved protein 0.0078 0.0158 0.0275
Entamoeba histolytica hypothetical protein 0.0194 0.052 0.2263
Mycobacterium ulcerans beta-lactamase 0.0078 0.0158 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0033 0.0129
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0141 0.0354 0.1383
Trypanosoma brucei calmodulin, putative 0.0099 0.0222 0.0379
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0127 0.0312 0.1218
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0372 0.1077 0.1512
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.022 0.0602 0.0845
Leishmania major hypothetical protein, unknown function 0.022 0.0602 0.1028
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0764 0.2301 0.4416
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0069 0.0097
Toxoplasma gondii histone deacetylase SIR2 0.0033 0.0016 0.0028
Brugia malayi Peptidase family M13 containing protein 0.0091 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0091 0.0199 0.0199
Schistosoma mansoni gabp alpha 0.0152 0.0388 0.0546
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0127 0.0312 0.1357
Plasmodium vivax proteasome subunit beta type-1, putative 0.0076 0.015 0.0652
Schistosoma mansoni calmodulin 0.0098 0.022 0.0309
Plasmodium vivax aspartyl protease, putative 0.0041 0.004 0.0176
Echinococcus granulosus calpain A 0.0751 0.226 0.3175
Schistosoma mansoni hypothetical protein 0.0632 0.1887 0.265
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.2103 0.6483 0.9106
Trichomonas vaginalis set domain proteins, putative 0.0725 0.218 0.851
Trypanosoma brucei prolyl endopeptidase 0.19 0.5851 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0053 0.0081 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.0027 0.002
Loa Loa (eye worm) aspartyl protease 6 0.0041 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0205 0.0553 0.0777
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.0152 0.0213
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0137 0.0234
Entamoeba histolytica cysteine proteinase 2 0.0425 0.1241 0.54
Schistosoma mansoni calpain-7 (C02 family) 0.0754 0.227 0.3188
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0158 0.0275
Loa Loa (eye worm) EF hand family protein 0.0098 0.022 0.022
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0072 0.0138 0.0478
Plasmodium vivax importin-beta 2, putative 0.0059 0.0099 0.0429
Toxoplasma gondii centrin 0.0098 0.022 0.0376
Echinococcus granulosus calcium uptake protein 1 0.0099 0.0222 0.0311
Echinococcus granulosus lamin 0.0055 0.0084 0.0118
Brugia malayi calpain family protein 1 0.2004 0.6177 0.6177
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0027 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0212 0.0212
Brugia malayi Ets-domain containing protein 0.0152 0.0388 0.0388
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0098 0.022 0.0309
Echinococcus multilocularis fat cadherin tumor suppressor 0.0053 0.0081 0.0113
Schistosoma mansoni hypothetical protein 0.0053 0.0081 0.0113
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0194 0.052 0.2263
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0075 0.0105
Loa Loa (eye worm) trypsin family protein 0.0082 0.0169 0.0169
Giardia lamblia Cathepsin L precursor 0.0194 0.052 0.2031
Giardia lamblia Encystation-specific protease 0.0194 0.052 0.2031
Onchocerca volvulus 0.0072 0.0137 0.0235
Brugia malayi EF hand family protein 0.0098 0.022 0.022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.0152 0.0593
Echinococcus granulosus EF HAND 1 calcium binding site 0.0098 0.022 0.0309
Schistosoma mansoni calmodulin related calcium binding protein 0.0098 0.022 0.0309
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.022 0.0602 0.2348
Onchocerca volvulus 0.0041 0.004 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0203 0.0285
Loa Loa (eye worm) hypothetical protein 0.0763 0.2298 0.2298
Onchocerca volvulus 0.005 0.0069 0.0118
Echinococcus multilocularis protein jagged 1 0.0053 0.0081 0.0113
Plasmodium vivax vivapain-3 0.0425 0.1241 0.54
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.005 0.0085
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0099 0.0168
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0203 0.0285
Echinococcus multilocularis cysteine protease 0.0763 0.2298 0.3228
Echinococcus multilocularis fibropellin Ia 0.0053 0.0081 0.0113
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0764 0.2301 0.3932
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0033 0.0047
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.013 0.032 0.032
Entamoeba histolytica cysteine proteinase, putative 0.0425 0.1241 0.54
Plasmodium falciparum thioredoxin reductase 0.0046 0.0056 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.0027 0.002
Loa Loa (eye worm) hypothetical protein 0.0212 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.0027 0.0041
Toxoplasma gondii EGF family domain-containing protein 0.0053 0.0081 0.0138
Brugia malayi Muscle positioning protein 4 0.0053 0.0081 0.0081
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0058 0.0081
Schistosoma mansoni cell polarity protein 0.0053 0.0081 0.0113
Echinococcus granulosus cysteine protease 0.0425 0.1241 0.1743
Loa Loa (eye worm) animal heme peroxidase 0.0577 0.1716 0.1716
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0425 0.1241 0.1743
Onchocerca volvulus 0.0533 0.1578 0.2696
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0033 0.0047
Schistosoma mansoni chromatin regulatory protein sir2 0.0127 0.0312 0.0438
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0058 0.0081
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.0199 0.028
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0098 0.022 0.0309
Trypanosoma cruzi calmodulin, putative 0.0098 0.022 0.0309
Loa Loa (eye worm) animal heme peroxidase 0.0577 0.1716 0.1716
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0035 0.0049
Loa Loa (eye worm) hypothetical protein 0.2004 0.6177 0.6177
Echinococcus multilocularis microtubule associated protein 2 0.139 0.4258 0.598
Brugia malayi MH2 domain containing protein 0.0366 0.1056 0.1056
Echinococcus multilocularis 0.0036 0.0027 0.0037
Mycobacterium ulcerans hypothetical protein 0.0082 0.0169 0.06
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.052 0.2031
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0751 0.226 0.3175
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0167 0.0435 0.1607
Trichomonas vaginalis peptide N-glycanase, putative 0.0072 0.0137 0.0536
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0033 0.0033
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0033 0.0016 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0056 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0276 0.0502
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.009 0.0127
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0051 0.0074 0.0103
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0033 0.0047
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.0027 0.002
Brugia malayi Cathepsin L-like precursor 0.0763 0.2298 0.2298
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0167 0.0435 0.0611
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2004 0.6177 0.8675
Plasmodium falciparum plasmepsin VII 0.0041 0.004 0.0176
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.022 0.0602 0.2348
Loa Loa (eye worm) Notch2 0.0053 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0068 0.0125 0.0125
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0056 0.0246
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0033 0.0047
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.009 0.0127
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0051 0.0074 0.032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0239 0.0431
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2306 0.712 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0194 0.052 0.052
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0016 0.0023
Schistosoma mansoni hypothetical protein 0.0053 0.0081 0.0113
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0033
Leishmania major kinesin, putative 0.0531 0.1573 0.2688
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Loa Loa (eye worm) hypothetical protein 0.006 0.0102 0.0102
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0256 0.0715 0.1222
Brugia malayi Cathepsin L-like cysteine proteinase 0.0533 0.1578 0.1578
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0372 0.1077 0.184
Echinococcus granulosus tumor protein p63 0.0702 0.2106 0.2958
Echinococcus granulosus acylamino acid releasing enzyme 0.0212 0.0575 0.0808
Brugia malayi cathepsin F-like cysteine proteinase 0.0194 0.052 0.052
Trypanosoma cruzi kinesin, putative 0.0531 0.1573 0.2209
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0033
Plasmodium falciparum plasmepsin IV 0.0041 0.004 0.0176
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.052 0.2263
Giardia lamblia Proteasome subunit beta type 2 0.0051 0.0074 0.0287
Brugia malayi prolyl oligopeptidase family protein 0.0372 0.1077 0.1077
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0194 0.052 0.052
Brugia malayi hypothetical protein 0.012 0.0289 0.0289
Plasmodium falciparum peptidase, putative 0.0212 0.0575 0.2502
Schistosoma mansoni ap endonuclease 0.0076 0.0152 0.0213
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Plasmodium vivax SET domain protein, putative 0.0092 0.0203 0.0882
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0602 0.2348
Schistosoma mansoni notch 0.0053 0.0081 0.0113
Echinococcus granulosus cathepsin l1 0.0533 0.1578 0.2216
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0194 0.052 0.2263
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Mycobacterium tuberculosis Probable peptidase 0.0764 0.2301 0.4416
Entamoeba histolytica grainin, putative 0.0099 0.0222 0.0965
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.3228 1 1
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0064 0.0248
Brugia malayi calpain 5 0.0531 0.1573 0.1573
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0194 0.052 0.0731
Entamoeba histolytica cysteine proteinase, putative 0.0533 0.1578 0.6864
Trypanosoma brucei hypothetical protein 0.022 0.0602 0.1028
Brugia malayi hypothetical protein 0.0577 0.1716 0.1716
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0076 0.015 0.0585
Trypanosoma brucei I/6 autoantigen 0.0098 0.022 0.0376
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0158 0.0275
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0033 0.0033
Trypanosoma cruzi cytochrome P450, putative 0.0072 0.0138 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0212 0.0297
Loa Loa (eye worm) sirtuin 4 0.0033 0.0016 0.0016
Schistosoma mansoni cathepsin D (A01 family) 0.0233 0.0641 0.0901
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0888 0.0888
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0203 0.0285
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0194 0.052 0.2031
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.022 0.0602 0.1028
Trypanosoma cruzi calmodulin, putative 0.0098 0.022 0.0309
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.0298 0.0509
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Loa Loa (eye worm) hypothetical protein 0.0091 0.0199 0.0199
Schistosoma mansoni slit 0.0053 0.0081 0.0113
Echinococcus granulosus cathepsin L 0.0194 0.052 0.0731
Giardia lamblia Cathepsin B precursor 0.0847 0.2561 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.009 0.0127
Schistosoma mansoni hypothetical protein 0.0098 0.022 0.0309
Plasmodium vivax vivapain-2 0.0763 0.2298 1
Schistosoma mansoni hypothetical protein 0.0494 0.1457 0.2046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0033
Trypanosoma cruzi centrin, putative 0.0102 0.0231 0.0325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0298 0.1104
Loa Loa (eye worm) hypothetical protein 0.0533 0.1578 0.1578
Schistosoma mansoni lamin 0.0055 0.0084 0.0118
Leishmania major hypothetical protein, conserved 0.022 0.0602 0.1028
Brugia malayi EGF-like domain containing protein 0.0053 0.0081 0.0081
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0152 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Toxoplasma gondii hypothetical protein 0.022 0.0602 0.1028
Echinococcus multilocularis calbindin 32 0.0099 0.0222 0.0311
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0425 0.1241 0.1743
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0203 0.0285
Loa Loa (eye worm) hypothetical protein 0.0082 0.0169 0.0169
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0203 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Trichomonas vaginalis hypothetical protein 0.022 0.0602 0.2348
Leishmania major cathepsin L-like protease 0.0763 0.2298 0.3928
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0158 0.0518
Plasmodium vivax aspartyl proteinase, putative 0.0041 0.004 0.0176
Echinococcus multilocularis notch 0.0053 0.0081 0.0113
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0212 0.0575 0.2502
Plasmodium falciparum plasmepsin V 0.0041 0.004 0.0176
Plasmodium falciparum serine repeat antigen 5 0.0194 0.052 0.2263
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0069 0.0117
Giardia lamblia Cathepsin L precursor 0.0194 0.052 0.2031
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0626 0.1871 0.2627
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0075 0.0105
Loa Loa (eye worm) hypothetical protein 0.0082 0.0169 0.0169
Entamoeba histolytica cysteine protease, putative 0.0194 0.052 0.2263
Loa Loa (eye worm) hypothetical protein 0.0231 0.0635 0.0635
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0069 0.0097
Plasmodium vivax aspartyl protease, putative 0.0205 0.0555 0.2416
Loa Loa (eye worm) calpain D 0.022 0.0602 0.0602
Trypanosoma brucei cytochrome P450, putative 0.0072 0.0138 0.0236
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0069
Trichomonas vaginalis calcineurin B subunit, putative 0.0099 0.0222 0.0866
Brugia malayi Calmodulin-like protein 0.0098 0.022 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.022 0.086
Schistosoma mansoni hypothetical protein 0.0053 0.0081 0.0113
Entamoeba histolytica hypothetical protein 0.0038 0.0033 0.0144
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0076 0.015 0.021
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Echinococcus multilocularis neuropeptide s receptor 0.0563 0.1674 0.2352
Onchocerca volvulus Chorion peroxidase homolog 0.0577 0.1716 0.2933
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0033 0.0047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Echinococcus granulosus peroxidasin 0.0577 0.1716 0.241
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.009 0.0127
Echinococcus multilocularis prolyl endopeptidase 0.19 0.5851 0.8219
Echinococcus multilocularis GA binding protein alpha chain 0.0152 0.0388 0.0546
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.005 0.007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Plasmodium falciparum serine repeat antigen 9 0.0194 0.052 0.2263
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0199 0.028
Brugia malayi proteasome subunit beta type 1 0.0076 0.015 0.015
Mycobacterium tuberculosis Long conserved protein 0.0072 0.0137 0.0234
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0847 0.2561 0.3598
Loa Loa (eye worm) hypothetical protein 0.0533 0.1578 0.1578
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.0152 0.0259
Echinococcus multilocularis calpain 0.0751 0.226 0.3175
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.0081 0.0081
Leishmania major sir2-family protein-like protein 0.0033 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Loa Loa (eye worm) MBCTL1 0.0056 0.009 0.009
Onchocerca volvulus 0.0053 0.0081 0.0138
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.005 0.007
Onchocerca volvulus Huntingtin homolog 0.012 0.0289 0.0494
Brugia malayi EGF-like domain containing protein 0.0053 0.0081 0.0081
Echinococcus granulosus cathepsin b 0.2306 0.712 1
Echinococcus granulosus neurocalcin 0.0098 0.022 0.0309
Brugia malayi EGF-like domain containing protein 0.0053 0.0081 0.0081
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0033 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.0027 0.002
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0212 0.0575 0.0808
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Loa Loa (eye worm) hypothetical protein 0.0098 0.022 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0035 0.0049
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.052 0.2263
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0167 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0082 0.0169 0.0169
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0141 0.0354 0.1383
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0051 0.0074 0.032
Trypanosoma cruzi cytochrome P450, putative 0.0072 0.0138 0.0194
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.005 0.0085
Plasmodium falciparum plasmepsin II 0.0041 0.004 0.0176
Trypanosoma brucei Calpain-like protein CALP1.3 0.022 0.0602 0.1028
Onchocerca volvulus Cathepsin F homolog 0.0763 0.2298 0.3928
Loa Loa (eye worm) beta-lactamase 0.0078 0.0158 0.0158
Mycobacterium tuberculosis Hypothetical protein 0.0072 0.0137 0.0234
Toxoplasma gondii aspartyl protease 0.0041 0.004 0.0069
Mycobacterium leprae Probable lipase LipE 0.0078 0.0158 0.0518
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.0027 0.0041
Trypanosoma cruzi conserved protein 0.022 0.0602 0.0845
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0849 0.2567 1
Onchocerca volvulus Peroxidase homolog 0.0577 0.1716 0.2933
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0763 0.2298 0.2298
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0888 0.3468
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0075 0.0127
Brugia malayi intermediate filament protein 0.0055 0.0084 0.0084
Loa Loa (eye worm) calpain 5 0.0531 0.1573 0.1573
Echinococcus multilocularis EF hand domain containing family member A2 0.0098 0.022 0.0309
Brugia malayi CXXC zinc finger family protein 0.0058 0.0094 0.0094
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0158 0.0275
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0231 0.0635 0.0635
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0256 0.0715 0.1222
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.052 0.2031
Trichomonas vaginalis calcium binding proteins, putative 0.0098 0.022 0.086
Loa Loa (eye worm) hypothetical protein 0.0212 0.0575 0.0575
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.2103 0.6483 0.9106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0533 0.1578 0.6159
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.2298 0.3228
Schistosoma mansoni ran 0.0044 0.005 0.007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0033 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0158
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Schistosoma mansoni memapsin-2 (A01 family) 0.0452 0.1327 0.1864
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0054 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.022 0.0602 0.2348
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0033 0.0016 0.0028
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.0298 0.0418
Echinococcus multilocularis protein jagged 2 0.0053 0.0081 0.0113
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0212 0.0575 0.2502
Onchocerca volvulus 0.0098 0.022 0.0376
Trypanosoma cruzi oligopeptidase b 0.0764 0.2301 0.3232
Schistosoma mansoni hypothetical protein 0.0072 0.0137 0.0193
Trichomonas vaginalis calcium binding protein, putative 0.0102 0.0231 0.0903
Trypanosoma brucei proteasome beta 6 subunit 0.0076 0.015 0.0256
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0082 0.0169 0.0169
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0239 0.0431
Brugia malayi prolyl oligopeptidase family protein 0.19 0.5851 0.5851
Onchocerca volvulus 0.0577 0.1716 0.2933
Leishmania major silent information regulator 2, putative 0.0127 0.0312 0.0533
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0075 0.0291
Leishmania major programmed cell death 6 protein-like protein 0.0098 0.022 0.0376
Trypanosoma cruzi centrin-3 0.0102 0.0231 0.0325
Brugia malayi MAP kinase sur-1 0.0051 0.0075 0.0075
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.0027 0.0041
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0194 0.052 0.2263
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0084 0.0084
Echinococcus multilocularis cathepsin L cysteine protease 0.0763 0.2298 0.3228
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.0027 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0425 0.1241 0.4846
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0027 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Brugia malayi hypothetical protein 0.0038 0.0033 0.0033
Onchocerca volvulus 0.0099 0.0222 0.0379
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Mycobacterium tuberculosis Conserved protein 0.0072 0.0137 0.0234
Echinococcus granulosus prolyl endopeptidase 0.19 0.5851 0.8219
Brugia malayi aspartic protease BmAsp-1, identical 0.0041 0.004 0.004
Brugia malayi Importin beta-1 subunit 0.0059 0.0099 0.0099
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0049 0.007
Echinococcus multilocularis hypothetical protein 0.0751 0.226 0.3175
Plasmodium falciparum centrin-1 0.0098 0.022 0.0958
Giardia lamblia Proteasome subunit beta type 1 0.0076 0.015 0.0585
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0064 0.0248
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0033 0.0016 0.0023
Mycobacterium leprae Conserved hypothetical protein 0.0072 0.0137 0.0436
Brugia malayi hypothetical protein 0.0038 0.0033 0.0033
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0033 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0847 0.2561 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0212 0.0575 0.2246
Echinococcus multilocularis expressed protein 0.0744 0.2238 0.3144
Brugia malayi prolyl oligopeptidase family protein 0.0212 0.0575 0.0575
Plasmodium falciparum plasmepsin VIII, putative 0.0041 0.004 0.0176
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0084 0.0084
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2103 0.6483 0.9106
Giardia lamblia Cysteine protease 0.0194 0.052 0.2031
Echinococcus granulosus geminin 0.0205 0.0553 0.0777
Entamoeba histolytica prolyl oligopeptidase family protein 0.0212 0.0575 0.2502
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Giardia lamblia Transcriptional regulator, Sir2 family 0.0033 0.0016 0.0063
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.0152 0.0262
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Giardia lamblia Cathepsin L precursor 0.0194 0.052 0.2031
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0058 0.0081
Schistosoma mansoni notch 0.0053 0.0081 0.0113
Brugia malayi EGF-like domain containing protein 0.0053 0.0081 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0888 0.3468
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0016 0.0016
Onchocerca volvulus 0.0053 0.0081 0.0138
Brugia malayi Animal haem peroxidase family protein 0.0577 0.1716 0.1716
Echinococcus granulosus cathepsin l1 0.0763 0.2298 0.3228
Echinococcus granulosus Mastin 0.0082 0.0169 0.0238
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0847 0.2561 0.3598
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0049 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.052 0.2031
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0033 0.0047
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0075 0.0105
Brugia malayi calpain 7 0.0751 0.226 0.226
Plasmodium falciparum proteasome subunit beta type-5 0.0167 0.0435 0.1892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0099 0.0138
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.022 0.0602 0.2348
Echinococcus multilocularis neuropeptide receptor A26 0.0563 0.1674 0.2352
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.0027 0.002
Echinococcus granulosus cathepsin l cysteine peptidase 0.0763 0.2298 0.3228
Loa Loa (eye worm) prolyl oligopeptidase 0.0372 0.1077 0.1077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0158 0.0222
Trypanosoma cruzi cysteine peptidase, putative 0.0857 0.2591 0.364
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.0298 0.0418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0158 0.0222
Loa Loa (eye worm) hypothetical protein 0.0468 0.1377 0.1377
Plasmodium vivax vivapain-2 0.0763 0.2298 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0027 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0152 0.0593
Trypanosoma cruzi I/6 autoantigen, putative 0.0098 0.022 0.0309
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0763 0.2298 0.3228
Mycobacterium ulcerans putative transglutaminase-like protein 0.0072 0.0137 0.0475
Trichomonas vaginalis calpain, putative 0.022 0.0602 0.2348
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.0027 0.0041
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Brugia malayi Cathepsin L-like precursor 0.0763 0.2298 0.2298
Plasmodium vivax glutathione reductase, putative 0.0046 0.0056 0.0246
Brugia malayi programmed cell death protein 6 0.0098 0.022 0.022
Onchocerca volvulus Peroxidasin homolog 0.0577 0.1716 0.2933
Giardia lamblia Cathepsin L-like protease 0.0194 0.052 0.2031
Schistosoma mansoni neuronal calcium sensor 0.0098 0.022 0.0309
Echinococcus granulosus cathepsin L cysteine proteinase 0.0763 0.2298 0.3228
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2973 0.4176
Brugia malayi mbt repeat family protein 0.005 0.0069 0.0069
Trichomonas vaginalis calmodulin, putative 0.0098 0.022 0.086
Loa Loa (eye worm) hypothetical protein 0.0141 0.0354 0.0354
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0064 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0222 0.0965
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.0027 0.0041
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0099 0.0222 0.0311
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0041 0.004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Giardia lamblia Cathepsin B precursor 0.0194 0.052 0.2031
Trypanosoma cruzi cysteine proteinase, putative 0.0425 0.1241 0.1743
Leishmania major cathepsin L-like protease 0.0763 0.2298 0.3928
Echinococcus granulosus caspase 3 0.0072 0.0139 0.0195
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0049 0.007
Leishmania major GTP-binding protein, putative 0.0044 0.005 0.0085
Plasmodium falciparum serine repeat antigen 1 0.0194 0.052 0.2263
Brugia malayi EGF-like domain containing protein 0.0053 0.0081 0.0081
Giardia lamblia Cathepsin B precursor 0.0847 0.2561 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0076 0.015 0.021
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0158 0.0275
Plasmodium falciparum glutathione reductase 0.0046 0.0056 0.0246
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0033
Leishmania major calmodulin-like protein 0.0098 0.022 0.0376
Onchocerca volvulus Dual oxidase homolog 0.0577 0.1716 0.2933
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.0575 0.0808
Trypanosoma brucei cysteine peptidase, putative 0.022 0.0602 0.1028
Schistosoma mansoni hypothetical protein 0.0041 0.0042 0.0059
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0099 0.0222 0.0311
Trypanosoma brucei Calpain-like protein 1.1 0.022 0.0602 0.1028
Brugia malayi Peroxidasin 0.0577 0.1716 0.1716
Entamoeba histolytica prolyl oligopeptidase family protein 0.0212 0.0575 0.2502
Plasmodium falciparum plasmepsin IX 0.0205 0.0555 0.2416
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0256 0.0715 0.1004
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0158 0.0618
Toxoplasma gondii proteasome subunit beta type, putative 0.0167 0.0435 0.0743
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.0573 0.0804
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Mycobacterium ulcerans hypothetical protein 0.0072 0.0137 0.0475
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0035 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0203 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0194 0.052 0.2031
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0425 0.1241 0.1743
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0055 0.0084 0.0084
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.0199 0.028
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0033 0.0047
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0751 0.226 0.3863
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0053 0.0081 0.0081
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0158 0.0557
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Toxoplasma gondii cathepsin CPL 0.0763 0.2298 0.3928
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0098 0.022 0.0309
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0016 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0553 0.2159
Onchocerca volvulus 0.1253 0.383 0.6545
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2306 0.712 1
Echinococcus granulosus protein jagged 2 0.0053 0.0081 0.0113
Brugia malayi Cathepsin L-like precursor 0.0763 0.2298 0.2298
Onchocerca volvulus 0.0103 0.0235 0.0401
Brugia malayi Cytochrome P450 family protein 0.0072 0.0138 0.0138
Brugia malayi Thioredoxin family protein 0.0072 0.0137 0.0137
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Schistosoma mansoni neuronal calcium sensor 0.0098 0.022 0.0309
Leishmania major cathepsin L-like protease 0.0763 0.2298 0.3928
Schistosoma mansoni cathepsin s 0.0231 0.0635 0.0891
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.0573 0.0804
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Loa Loa (eye worm) calmodulin-like protein 0.0098 0.022 0.022
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0425 0.1241 0.1743
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0194 0.052 0.2031
Plasmodium vivax vivapain-1 0.0425 0.1241 0.54
Giardia lamblia Sirtuin type 2 0.0033 0.0016 0.0063
Loa Loa (eye worm) calpain family protein 1 0.2004 0.6177 0.6177
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0194 0.052 0.2263
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Loa Loa (eye worm) proteasome subunit beta type 1 0.0076 0.015 0.015
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0099 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0098 0.022 0.0376
Toxoplasma gondii peptidase family M13 protein 0.0091 0.0199 0.0341
Trypanosoma cruzi cruzipain precursor, putative 0.0857 0.2591 0.364
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0056 0.0078
Brugia malayi Papain family cysteine protease containing protein 0.0425 0.1241 0.1241
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0763 0.2298 0.2298
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0053 0.0081 0.0113
Giardia lamblia Cathepsin L precursor 0.0194 0.052 0.2031
Giardia lamblia Cathepsin L precursor 0.0194 0.052 0.2031
Brugia malayi cytochrome P450 0.0036 0.0027 0.0027
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0167 0.0435 0.1698
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0099 0.0222 0.0379
Brugia malayi Cathepsin L-like precursor 0.0533 0.1578 0.1578
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.052 0.2031
Brugia malayi hypothetical protein 0.0082 0.0169 0.0169
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.052 0.0731
Schistosoma mansoni ets-related 0.0461 0.1355 0.1903
Plasmodium falciparum cysteine proteinase falcipain 1 0.0425 0.1241 0.54
Onchocerca volvulus 0.0058 0.0094 0.0161
Brugia malayi hypothetical protein 0.0151 0.0384 0.0384
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0069 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0075 0.0105
Schistosoma mansoni neuronal calcium sensor 0.0098 0.022 0.0309
Loa Loa (eye worm) animal heme peroxidase 0.0577 0.1716 0.1716
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0098 0.022 0.0309
Leishmania major calmodulin, putative 0.0098 0.022 0.0376
Echinococcus granulosus programmed cell death protein 0.0102 0.0231 0.0325
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0082 0.0169 0.0238
Toxoplasma gondii cathepsin CPC1 0.0194 0.052 0.0889
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0888 0.3468
Trypanosoma brucei protein I/6 0.0098 0.022 0.0376
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Toxoplasma gondii ABC1 family protein 0.0078 0.0158 0.027
Brugia malayi Cathepsin L-like precursor 0.0533 0.1578 0.1578
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0033 0.0047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.0152 0.0152
Echinococcus granulosus delta-like protein 1 0.0053 0.0081 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0033 0.0047
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0016 0.0016
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0212 0.0575 0.0983
Brugia malayi fibroinase precursor 0.0194 0.052 0.052
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.0199 0.0718
Trichomonas vaginalis calmodulin, putative 0.0098 0.022 0.086
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0102 0.0102
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0751 0.226 0.3175
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.022 0.0602 0.2348
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0033 0.0016 0.007
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0098 0.022 0.086
Toxoplasma gondii troponin c, isotype gamma, putative 0.0098 0.022 0.0376
Brugia malayi PXA domain containing protein 0.0038 0.0033 0.0033
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0235 0.033
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.0152 0.5
Giardia lamblia Cathepsin B precursor 0.0194 0.052 0.2031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.052 0.2031
Echinococcus granulosus calumenin 0.0099 0.0222 0.0311
Leishmania major hypothetical protein, conserved 0.005 0.0069 0.0117
Onchocerca volvulus 0.0082 0.0169 0.0289
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.0152 0.0213
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0098 0.022 0.086
Loa Loa (eye worm) hypothetical protein 0.19 0.5851 0.5851
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.0152 0.0259
Plasmodium vivax plasmepsin IV, putative 0.0041 0.004 0.0176
Brugia malayi Animal haem peroxidase family protein 0.0577 0.1716 0.1716
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.052 0.2263
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0194 0.052 0.2263
Loa Loa (eye worm) fibroinase 0.0763 0.2298 0.2298
Mycobacterium ulcerans transglutaminase family protein 0.0072 0.0137 0.0475
Echinococcus granulosus calpain A 0.2103 0.6484 0.9108
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.022 0.0602 0.0845
Echinococcus multilocularis chromatin regulatory protein sir2 0.0127 0.0312 0.0438
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0158 0.0222
Loa Loa (eye worm) hypothetical protein 0.0045 0.0054 0.0054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0203 0.0285
Trypanosoma brucei prolyl oligopeptidase, putative 0.0764 0.2301 0.3932
Plasmodium vivax centrin-1, putative 0.0098 0.022 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.052 0.2031
Onchocerca volvulus 0.0763 0.2298 0.3928
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0051 0.0074 0.0126
Echinococcus granulosus neuropeptide receptor A26 0.0563 0.1674 0.2352
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.005 0.007
Plasmodium vivax hypothetical protein, conserved 0.0212 0.0575 0.2502
Echinococcus multilocularis neurocalcin 0.0098 0.022 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0033 0.0129
Entamoeba histolytica cysteine protease, putative 0.0763 0.2298 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Leishmania major trypanothione reductase 0.0046 0.0056 0.0096
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0194 0.052 0.2031
Echinococcus granulosus caspase 0.0098 0.0221 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.0575 0.2246
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0158 0.0275
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0194 0.052 0.2263
Echinococcus multilocularis glycoprotein Antigen 5 0.0082 0.0169 0.0238
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0053 0.0081 0.0138
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0194 0.052 0.2263
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.0027 0.0041
Leishmania major calmodulin, putative 0.0098 0.022 0.0376
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Trypanosoma cruzi cysteine proteinase, putative 0.0425 0.1241 0.1743
Plasmodium vivax NAD-dependent deacetylase, putative 0.0033 0.0016 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0138 0.0138
Schistosoma mansoni septate junction protein 0.0053 0.0081 0.0113
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0256 0.0715 0.1004
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0372 0.1077 0.1512
Echinococcus granulosus neuropeptide s receptor 0.0563 0.1674 0.2352
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0158 0.0222
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0028 0.0001 0.0006
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.0027 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0188 0.0264
Trypanosoma cruzi centrin, putative 0.0102 0.0231 0.0325
Entamoeba histolytica protein kinase, putative 0.0531 0.1574 0.6848
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.0152 0.0213
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0231 0.0635 0.0635
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0256 0.0715 0.1222
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.0199 0.0354
Echinococcus multilocularis cathepsin L cysteine protease 0.0763 0.2298 0.3228
Entamoeba histolytica cysteine proteinase, putative 0.0425 0.1241 0.54
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.0027 0.0041
Schistosoma mansoni ran 0.0044 0.005 0.007
Schistosoma mansoni hypothetical protein 0.0053 0.0081 0.0113
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Schistosoma mansoni cpg binding protein 0.0058 0.0094 0.0133
Onchocerca volvulus 0.0577 0.1716 0.2933
Onchocerca volvulus Slit protein homolog 0.0053 0.0081 0.0138
Loa Loa (eye worm) cytochrome P450 0.0036 0.0027 0.0027
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3175
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.052 0.0731
Plasmodium falciparum serine repeat antigen 7 0.0194 0.052 0.2263
Trypanosoma cruzi cysteine peptidase, putative 0.0231 0.0635 0.0891
Loa Loa (eye worm) hypothetical protein 0.0194 0.052 0.052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Schistosoma mansoni reticulocalbin 0.0099 0.0222 0.0311
Brugia malayi Papain family cysteine protease containing protein 0.0763 0.2298 0.2298
Schistosoma mansoni hypothetical protein 0.0082 0.0169 0.0238
Onchocerca volvulus Cathepsin L homolog 0.0763 0.2298 0.3928
Trypanosoma brucei oligopeptidase b 0.0764 0.2301 0.3932
Brugia malayi Cadherin domain containing protein 0.0053 0.0081 0.0081
Brugia malayi calpain family protein 1 0.2004 0.6177 0.6177
Trypanosoma brucei Component of motile flagella 41 0.0098 0.022 0.0376
Trypanosoma brucei caltractin, putative 0.0102 0.0231 0.0395
Giardia lamblia Cathepsin B precursor 0.0194 0.052 0.2031
Loa Loa (eye worm) hypothetical protein 0.0056 0.009 0.009
Trypanosoma brucei centrin, putative 0.0098 0.022 0.0376
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0763 0.2298 0.3228
Mycobacterium ulcerans proteasome PrcA 0.0849 0.2567 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0033 0.0129
Brugia malayi Cathepsin L-like precursor 0.0763 0.2298 0.2298
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0152 0.0388 0.0388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0637 0.1905 0.1905
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0158
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0033 0.0016 0.007
Echinococcus granulosus glycoprotein Antigen 5 0.0082 0.0169 0.0238
Loa Loa (eye worm) cytochrome P450 family protein 0.0134 0.0333 0.0333
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0076 0.015 0.021
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0041 0.004 0.0069
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0033 0.0047
Entamoeba histolytica calpain family cysteine protease, putative 0.022 0.0602 0.2617
Trypanosoma brucei mitochondrial calcium uptake 1 0.0098 0.022 0.0376
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.0298 0.0509
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0764 0.2301 0.8953
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Schistosoma mansoni caspase-3 (C14 family) 0.0098 0.0221 0.031
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.052 0.052
Trypanosoma cruzi kinesin, putative 0.0531 0.1573 0.2209
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.052 0.2031
Schistosoma mansoni hypothetical protein 0.0096 0.0212 0.0298
Toxoplasma gondii thioredoxin reductase 0.0046 0.0056 0.0096
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0098 0.022 0.0309
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.0027 0.002
Onchocerca volvulus Huntingtin homolog 0.012 0.0289 0.0494
Loa Loa (eye worm) hypothetical protein 0.0533 0.1578 0.1578
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0033 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0069 0.0096
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.005
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1457 0.2046
Trichomonas vaginalis calpain, putative 0.022 0.0602 0.2348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0276 0.098
Giardia lamblia High cysteine protein 0.0053 0.0081 0.0315
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0069 0.0298
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.0845
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0069 0.0096
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0194 0.052 0.052
Onchocerca volvulus 0.0082 0.0169 0.0289
Loa Loa (eye worm) hypothetical protein 0.0041 0.0042 0.0042
Trichomonas vaginalis centrin, putative 0.0098 0.022 0.086
Trichomonas vaginalis calpain, putative 0.022 0.0602 0.2348
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Trichomonas vaginalis calcium binding protein, putative 0.0098 0.022 0.086
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.0027 0.002
Trichomonas vaginalis calmodulin, putative 0.0099 0.0222 0.0866
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.022 0.0602 0.0845
Entamoeba histolytica calmodulin, putative 0.0098 0.022 0.0958
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.022 0.0602 0.1028
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.0027 0.002
Brugia malayi Thioredoxin reductase 0.0046 0.0056 0.0056
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.0081 0.0081
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0082 0.0169 0.0238
Schistosoma mansoni lamin 0.0055 0.0084 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0035 0.0049
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0212 0.0297
Entamoeba histolytica hypothetical protein, conserved 0.0099 0.0222 0.0965
Onchocerca volvulus 0.0763 0.2298 0.3928
Leishmania major hypothetical protein, conserved 0.0099 0.0222 0.0379
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0764 0.2301 0.3932
Entamoeba histolytica cysteine protease, putative 0.0194 0.052 0.2263
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0082 0.0169 0.0238
Toxoplasma gondii calcium-dependent protein kinase 0.0099 0.0223 0.0381
Brugia malayi hypothetical protein 0.0041 0.004 0.004
Onchocerca volvulus 0.0763 0.2298 0.3928
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0137 0.0234
Onchocerca volvulus 0.0053 0.0081 0.0138
Onchocerca volvulus 0.0096 0.0212 0.0363
Onchocerca volvulus 0.0763 0.2298 0.3928
Echinococcus granulosus protein jagged 1 0.0053 0.0081 0.0113
Giardia lamblia Hypothetical protein 0.0194 0.052 0.2031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0763 0.2298 0.8974
Leishmania major cytochrome p450-like protein 0.0036 0.0027 0.0045
Schistosoma mansoni ap endonuclease 0.0076 0.0152 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.0027 0.002
Schistosoma mansoni survival motor neuron protein 0.0096 0.0212 0.0298
Plasmodium vivax unspecified product 0.0194 0.052 0.2263
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0069 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Echinococcus granulosus calpain 5 0.0751 0.226 0.3175
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.0152 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.022 0.086
Schistosoma mansoni reticulocalbin 0.0098 0.022 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0033 0.0129
Loa Loa (eye worm) hypothetical protein 0.0059 0.0099 0.0099
Leishmania major proteasome beta 5 subunit, putative 0.0167 0.0435 0.0743
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0051 0.0074 0.0103
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0082 0.0169 0.0169
Plasmodium vivax proteasome subunit beta type-5, putative 0.0167 0.0435 0.1892
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2306 0.712 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Entamoeba histolytica cysteine proteinase, putative 0.0425 0.1241 0.54
Brugia malayi Cathepsin L-like precursor 0.0231 0.0635 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0425 0.1241 0.2121
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0152 0.0593
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.0027 0.0041
Plasmodium falciparum serine repeat antigen 4 0.0194 0.052 0.2263
Loa Loa (eye worm) animal heme peroxidase 0.0577 0.1716 0.1716
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0158 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.052 0.2031
Loa Loa (eye worm) hypothetical protein 0.0082 0.0169 0.0169
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0027 0.0037
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Brugia malayi beta-lactamase family protein 0.0078 0.0158 0.0158
Onchocerca volvulus 0.0053 0.0081 0.0138
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0158 0.0275
Schistosoma mansoni centrin 0.0098 0.022 0.0309
Plasmodium falciparum serine repeat antigen 3 0.0194 0.052 0.2263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0058 0.0081
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0069 0.0118
Trypanosoma brucei calpain-like protein, putative 0.0751 0.226 0.3863
Echinococcus granulosus protein jagged 1 0.0053 0.0081 0.0113
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0027 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Schistosoma mansoni notch 0.0054 0.0081 0.0114
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Echinococcus multilocularis cpg binding protein 0.0061 0.0105 0.0147
Echinococcus granulosus neuronal calcium sensor 0.0098 0.022 0.0309
Brugia malayi Cathepsin L-like precursor 0.0763 0.2298 0.2298
Schistosoma mansoni hypothetical protein 0.0053 0.0081 0.0113
Trypanosoma cruzi cysteine peptidase, putative 0.0857 0.2591 0.364
Schistosoma mansoni hypothetical protein 0.0043 0.0049 0.007
Giardia lamblia Hypothetical protein 0.0099 0.0222 0.0866
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0372 0.1077 0.1512
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0167 0.0435 0.0611
Schistosoma mansoni intermediate filament proteins 0.0055 0.0084 0.0118
Brugia malayi notch-like transmembrane receptor 0.0053 0.0081 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0298 0.1104
Trichomonas vaginalis calcium binding protein, putative 0.0098 0.022 0.086
Echinococcus granulosus expressed protein 0.0744 0.2238 0.3144
Loa Loa (eye worm) transcriptional regulator 0.0127 0.0312 0.0312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Plasmodium falciparum plasmepsin III 0.0041 0.004 0.0176
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0064 0.0248
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Trypanosoma brucei calpain, putative 0.022 0.0602 0.1028
Loa Loa (eye worm) cathepsin B 0.0847 0.2561 0.2561
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0212 0.0297
Echinococcus multilocularis calumenin 0.0099 0.0222 0.0311
Trypanosoma brucei calpain-like protein, putative 0.0751 0.226 0.3863
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0194 0.052 0.052
Echinococcus multilocularis programmed cell death protein 0.0102 0.0231 0.0325
Trypanosoma brucei kinesin, putative 0.0531 0.1573 0.2688
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.005 0.0217
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.0027 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Echinococcus multilocularis neurogenic locus notch protein 0.0053 0.0081 0.0113
Trichomonas vaginalis calcineurin B subunit, putative 0.0098 0.022 0.086
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.052 0.052
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.0027 0.0041
Trypanosoma brucei Calpain-like protein 1.2 0.022 0.0602 0.1028
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0074 0.0287
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Giardia lamblia Cysteine protease 0.0194 0.052 0.2031
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0033 0.0047
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0215
Onchocerca volvulus Cathepsin L homolog 0.0763 0.2298 0.3928
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.0027 0.0041
Brugia malayi EF hand family protein 0.0099 0.0222 0.0222
Echinococcus multilocularis neurogenic locus notch protein 4 0.0053 0.0081 0.0113
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Plasmodium falciparum importin beta, putative 0.0059 0.0099 0.0429
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0588 0.2294
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0084 0.0084
Leishmania major cysteine peptidase A (CPA) 0.0763 0.2298 0.3928
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0847 0.2561 0.4377
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0055 0.0055
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0075 0.0127
Brugia malayi Papain family cysteine protease containing protein 0.0425 0.1241 0.1241
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0194 0.052 0.2031
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0033 0.0129
Echinococcus multilocularis Transglutaminase 0.0072 0.0137 0.0193
Schistosoma mansoni cathepsin F (C01 family) 0.0763 0.2298 0.3228
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0751 0.226 0.3175
Onchocerca volvulus 0.0082 0.0169 0.0289
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Echinococcus multilocularis survival motor neuron protein 1 0.0468 0.1377 0.1934
Entamoeba histolytica calpain large subunit domain III containing protein 0.0531 0.1573 0.6842
Onchocerca volvulus Neurogenic locus notch homolog 0.0054 0.0081 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0888 0.3468
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0256 0.0715 0.1004
Brugia malayi Trypsin family protein 0.0082 0.0169 0.0169
Brugia malayi Ets-domain containing protein 0.0152 0.0388 0.0388
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0212 0.0297
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0075 0.0291
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0033 0.0047
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.052 0.052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0212 0.0212
Leishmania major centrin, putative 0.0098 0.022 0.0376
Mycobacterium tuberculosis Probable reductase 0.0104 0.0239 0.0431
Trichomonas vaginalis calmodulin, putative 0.0098 0.022 0.086
Loa Loa (eye worm) hypothetical protein 0.0231 0.0635 0.0635
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0033 0.0047
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0058 0.0081
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.022 0.0602 0.0845
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0033 0.0047
Toxoplasma gondii preprocathepsin c precursor, putative 0.0194 0.052 0.0889
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0764 0.2301 0.3232
Plasmodium vivax aspartyl proteinase, putative 0.0041 0.004 0.0176
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0005 0.0005
Onchocerca volvulus Peroxidasin homolog 0.0577 0.1716 0.2933
Schistosoma mansoni calmodulin 0.0098 0.022 0.0309
Brugia malayi cathepsin B-like cysteine proteinase 0.2306 0.712 0.712
Trypanosoma cruzi calpain cysteine peptidase, putative 0.022 0.0602 0.0845
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0849 0.2567 0.493
Entamoeba histolytica calcium-binding protein, putative 0.0098 0.022 0.0958
Brugia malayi Animal haem peroxidase family protein 0.0577 0.1716 0.1716
Leishmania major proteasome beta 2 subunit, putative 0.0051 0.0074 0.0126
Brugia malayi mbt repeat family protein 0.005 0.0069 0.0069
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0098 0.022 0.0376
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Onchocerca volvulus 0.0053 0.0081 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.0025 0.0025
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0016 0.007
Trypanosoma brucei centrin, putative 0.0098 0.022 0.0376
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.022 0.0602 0.2348
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.19 0.5851 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0152 0.066
Schistosoma mansoni hypothetical protein 0.0098 0.022 0.0309
Trypanosoma cruzi calmodulin, putative 0.0098 0.022 0.0309
Onchocerca volvulus Cathepsin L homolog 0.0194 0.052 0.0889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.052 0.2031
Plasmodium vivax proteasome subunit beta type-2, putative 0.0051 0.0074 0.032
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.0027 0.002
Echinococcus granulosus neurogenic locus notch protein 0.0053 0.0081 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.0575 0.0808
Loa Loa (eye worm) hypothetical protein 0.0231 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.0205 0.0553 0.0777
Toxoplasma gondii EFHC1, putative 0.0098 0.022 0.0376
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0076 0.015 0.0256
Entamoeba histolytica calmodulin, putative 0.0098 0.022 0.0958
Loa Loa (eye worm) hypothetical protein 0.0068 0.0125 0.0125
Trypanosoma cruzi I/6 autoantigen, putative 0.0098 0.022 0.0309
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0051 0.0074 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Echinococcus multilocularis calpain 5 0.0751 0.226 0.3175
Trypanosoma cruzi major cysteine proteinase, putative 0.0288 0.0813 0.1142
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0553 0.2159
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0076 0.015 0.021
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0076 0.015 0.0256
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.052 0.0731
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0098 0.0221 0.031
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.19 0.5851 0.8219
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Echinococcus granulosus cathepsin b 0.2306 0.712 1
Mycobacterium leprae Conserved hypothetical protein 0.0072 0.0137 0.0436
Onchocerca volvulus 0.0763 0.2298 0.3928
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0076 0.015 0.0652
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0075 0.0105
Echinococcus granulosus neurogenic locus notch protein 4 0.0053 0.0081 0.0113
Trypanosoma brucei trypanothione reductase 0.0046 0.0056 0.0096
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0075 0.0291
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0239 0.0431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1689 0.519 1
Schistosoma mansoni hypothetical protein 0.0317 0.0904 0.127
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0033 0.0047
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0033 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.0027 0.002
Plasmodium falciparum serine repeat antigen 6 0.0194 0.052 0.2263
Echinococcus multilocularis cathepsin b 0.2306 0.712 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0888 0.3468
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.0298 0.0544
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Echinococcus granulosus cathepsin L cysteine protease 0.0425 0.1241 0.1743
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0075 0.0075
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0167 0.0435 0.1892
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0141 0.0354 0.0498
Onchocerca volvulus 0.0078 0.0158 0.027
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.052 0.2263
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0127 0.0312 0.0438
Trichomonas vaginalis ran, putative 0.0044 0.005 0.0194
Onchocerca volvulus 0.0082 0.0169 0.0289
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0016 0.0063
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0005 0.0005
Trypanosoma cruzi 20S proteasome subunit 0.0051 0.0074 0.0103
Onchocerca volvulus 0.0092 0.0203 0.0346
Echinococcus granulosus fibropellin Ia 0.0053 0.0081 0.0113
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0194 0.052 0.052
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0016 0.007
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3863
Echinococcus multilocularis enteropeptidase 0.0082 0.0169 0.0238
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0127 0.0312 0.1218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Schistosoma mansoni peroxidasin 0.0577 0.1716 0.241
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.0199 0.068
Plasmodium vivax unspecified product 0.0231 0.0635 0.2761
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0033
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.052 0.2031
Echinococcus multilocularis calmodulin 0.0098 0.022 0.0309
Brugia malayi RNA, U transporter 1 0.0168 0.0439 0.0439
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0212 0.0212
Echinococcus multilocularis peroxidasin 0.0577 0.1716 0.241
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0076 0.015 0.0652
Echinococcus granulosus calbindin 32 0.0099 0.0222 0.0311
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0098 0.022 0.0309
Onchocerca volvulus 0.0725 0.218 0.3726
Brugia malayi hypothetical protein 0.0468 0.1377 0.1377
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.0027 0.0041
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.0027 0.0041
Echinococcus granulosus calpain 0.0751 0.226 0.3175
Schistosoma mansoni cathepsin F (C01 family) 0.0533 0.1578 0.2216
Plasmodium vivax calpain, putative 0.0751 0.226 0.9834
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0158
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0075 0.0105
Entamoeba histolytica cysteine protease, putative 0.0194 0.052 0.2263
Brugia malayi Pre-SET motif family protein 0.0637 0.1905 0.1905
Trichomonas vaginalis calmodulin, putative 0.0098 0.022 0.086
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0099 0.0222 0.0964
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0298 0.0418
Onchocerca volvulus 0.0194 0.052 0.0889
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0075 0.0127
Brugia malayi hypothetical protein 0.0043 0.0049 0.0049
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.052 0.0731
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0098 0.022 0.0309
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0033 0.0016 0.007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Loa Loa (eye worm) prolyl oligopeptidase 0.0212 0.0575 0.0575
Plasmodium falciparum cysteine proteinase falcipain 3 0.0763 0.2298 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0041 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Loa Loa (eye worm) hypothetical protein 0.0098 0.022 0.022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3175
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0033 0.0129
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0158 0.0618
Echinococcus granulosus transmembrane protease serine 3 0.0082 0.0169 0.0238
Toxoplasma gondii EF hand domain-containing protein 0.0098 0.022 0.0376
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0298 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Toxoplasma gondii prolyl endopeptidase 0.19 0.5851 1
Onchocerca volvulus 0.0098 0.022 0.0376
Schistosoma mansoni hypothetical protein 0.022 0.0602 0.0845
Loa Loa (eye worm) hypothetical protein 0.2306 0.712 0.712
Echinococcus multilocularis neural cadherin 0.0053 0.0081 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0035 0.0049
Onchocerca volvulus 0.0763 0.2298 0.3928
Echinococcus granulosus snurportin 1 0.0632 0.1887 0.265
Plasmodium vivax aspartyl protease, putative 0.0205 0.0555 0.2416
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0276 0.0502
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0033 0.0047
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Loa Loa (eye worm) hypothetical protein 0.1784 0.5489 0.5489
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0888 0.3468
Brugia malayi beta-lactamase 0.0078 0.0158 0.0158
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.0027 0.0041
Trichomonas vaginalis calcium binding protein, putative 0.0098 0.022 0.086
Giardia lamblia Cathepsin B precursor 0.0194 0.052 0.2031
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.022 0.0602 0.0845
Loa Loa (eye worm) hypothetical protein 0.0068 0.0125 0.0125
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.005 0.0217
Trypanosoma cruzi oligopeptidase b 0.0764 0.2301 0.3232
Echinococcus granulosus lamin dm0 0.0055 0.0084 0.0118
Trichomonas vaginalis calmodulin, putative 0.0098 0.022 0.086
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0094 0.0094
Echinococcus multilocularis caspase 0.0098 0.0221 0.031
Echinococcus granulosus EF hand domain containing family member A2 0.0099 0.0222 0.0311
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.022 0.0602 0.0845
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0016 0.0063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0239 0.0837
Loa Loa (eye worm) cysteine protease 0.0763 0.2298 0.2298
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0194 0.052 0.052
Giardia lamblia Hypothetical protein 0.0127 0.0312 0.1218
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.0027 0.002
Echinococcus multilocularis cathepsin L 0.0194 0.052 0.0731
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.009 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Schistosoma mansoni chromatin regulatory protein sir2 0.0141 0.0354 0.0498
Echinococcus granulosus chromatin regulatory protein sir2 0.0127 0.0312 0.0438
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0099 0.0222 0.0311
Brugia malayi beta-lactamase family protein 0.0078 0.0158 0.0158
Schistosoma mansoni calpain-2 (C02 family) 0.022 0.0602 0.0845
Echinococcus granulosus enteropeptidase 0.0082 0.0169 0.0238
Onchocerca volvulus 0.0041 0.004 0.0069
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.0027 0.0041
Brugia malayi Cathepsin L-like precursor 0.0763 0.2298 0.2298
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0553 0.2159
Echinococcus multilocularis snurportin 1 0.0632 0.1887 0.265
Echinococcus multilocularis cathepsin b 0.2306 0.712 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0212 0.0297
Onchocerca volvulus Prolyl endopeptidase homolog 0.19 0.5851 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0158 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.052 0.2031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0763 0.2298 0.8974
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0127 0.0312 0.1357
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0266 0.0455
Mycobacterium ulcerans lipase LipD 0.0078 0.0158 0.0557
Onchocerca volvulus 0.0082 0.0169 0.0289
Trypanosoma brucei calpain-like protein, putative 0.0751 0.226 0.3863
Giardia lamblia Cathepsin B precursor 0.0194 0.052 0.2031
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0069 0.0117
Schistosoma mansoni cpg binding protein 0.0061 0.0105 0.0147
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.052 0.052
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0167 0.0435 0.0743
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0058 0.0082
Schistosoma mansoni Mername-AA248 (C02 family) 0.0751 0.226 0.3175
Brugia malayi prolyl oligopeptidase family protein 0.0256 0.0715 0.0715
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0212 0.0575 0.2246
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0016 0.0023
Onchocerca volvulus 0.0055 0.0084 0.0144
Echinococcus granulosus neural cadherin 0.0053 0.0081 0.0113
Trypanosoma cruzi major cysteine proteinase, putative 0.0194 0.052 0.0731
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0041 0.004 0.0158
Leishmania major cathepsin L-like protease 0.0857 0.2591 0.4429
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0127 0.0312 0.0438
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3863
Loa Loa (eye worm) hypothetical protein 0.0082 0.0169 0.0169
Leishmania major cytochrome p450-like protein 0.0072 0.0138 0.0236
Brugia malayi Eukaryotic aspartyl protease family protein 0.0041 0.004 0.004
Entamoeba histolytica grainin 2 0.0102 0.0231 0.1006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.005 0.007
Echinococcus granulosus slit 2 protein 0.0053 0.0081 0.0113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0307 0.0432
Plasmodium vivax plasmepsin V, putative 0.0041 0.004 0.0176
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0069
Echinococcus multilocularis neurogenic locus notch protein 0.0053 0.0081 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Echinococcus multilocularis calpain A 0.2103 0.6484 0.9108
Trypanosoma brucei antigen, putative 0.0751 0.226 0.3863
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0763 0.2298 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0239 0.0431
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0033 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0425 0.1241 0.4846
Toxoplasma gondii aspartyl protease ASP1 0.0041 0.004 0.0069
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0051 0.0074 0.0103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.052 0.0731
Mycobacterium tuberculosis Possible penicillin-binding protein 0.05 0.1476 0.2821
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.0027 0.002
Echinococcus multilocularis neurogenic locus protein delta 0.0053 0.0081 0.0113
Echinococcus multilocularis lamin dm0 0.0055 0.0084 0.0118
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0016 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Schistosoma mansoni calpain (C02 family) 0.0751 0.226 0.3175
Leishmania major cathepsin L-like protease 0.0857 0.2591 0.4429
Brugia malayi GCC2 and GCC3 family protein 0.0053 0.0081 0.0081
Onchocerca volvulus 0.0078 0.0158 0.027
Echinococcus granulosus cpg binding protein 0.0061 0.0105 0.0147
Brugia malayi glutathione reductase 0.0046 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.052 0.2031
Giardia lamblia Cysteine protease 0.0194 0.052 0.2031
Onchocerca volvulus 0.0078 0.0158 0.027
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0212 0.0575 0.0808
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0158 0.0618
Leishmania major calcineurin B subunit, putative 0.0098 0.022 0.0376
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0033 0.0033
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0051 0.0074 0.0103
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.0152 0.066
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Onchocerca volvulus 0.0082 0.0169 0.0289
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0194 0.052 0.2263
Loa Loa (eye worm) hypothetical protein 0.0103 0.0235 0.0235
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.0027 0.002
Leishmania major calmodulin-like protein 0.0098 0.022 0.0376
Echinococcus granulosus calmodulin 0.0098 0.022 0.0309
Loa Loa (eye worm) glutathione reductase 0.0046 0.0056 0.0056
Mycobacterium tuberculosis Conserved protein 0.0078 0.0158 0.0275
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Loa Loa (eye worm) fli-1 protein 0.0461 0.1355 0.1355
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0158 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0857 0.2591 0.4429
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0016 0.007
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.0027 0.0041
Entamoeba histolytica hypothetical protein 0.0038 0.0033 0.0144
Brugia malayi hypothetical protein 0.005 0.0069 0.0069
Mycobacterium ulcerans hypothetical protein 0.0072 0.0137 0.0475
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0033 0.0047
Brugia malayi EGF-like domain containing protein 0.0053 0.0081 0.0081
Brugia malayi PXA domain containing protein 0.0038 0.0033 0.0033
Echinococcus multilocularis slit 2 protein 0.0053 0.0081 0.0113
Leishmania major hypothetical protein, conserved 0.0098 0.022 0.0376
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0194 0.052 0.0731
Leishmania major calpain protease-like protein 0.022 0.0602 0.1028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0102 0.0102
Plasmodium falciparum calpain 0.022 0.0602 0.2617
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0158 0.0688
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.009 0.009
Echinococcus granulosus protein jagged 2 0.0053 0.0081 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0099 0.0222 0.0311
Echinococcus multilocularis calpain family protein 1, d 0.1473 0.4518 0.6345
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Schistosoma mansoni calpain-7 (C02 family) 0.0754 0.227 0.3188
Brugia malayi calcium-binding protein 0.0098 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0069 0.013 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0553 0.2159
Onchocerca volvulus 0.0055 0.0084 0.0144
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0169 0.0238
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0764 0.2301 0.8958
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0125 0.0125
Echinococcus granulosus GA binding protein alpha chain 0.0152 0.0388 0.0546
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0194 0.052 0.2263
Trichomonas vaginalis calmodulin, putative 0.0102 0.0231 0.0903
Toxoplasma gondii cathepsin B 0.0847 0.2561 0.4377
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0158
Schistosoma mansoni cathepsin B (C01 family) 0.0194 0.052 0.0731
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0041 0.004 0.0057
Entamoeba histolytica cysteine protease, putative 0.0425 0.1241 0.54
Brugia malayi calpain D 0.022 0.0602 0.0602
Brugia malayi cathepsin L precursor 0.0194 0.052 0.052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.0152 0.0532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0035 0.0035
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.022 0.0602 0.1028
Trypanosoma brucei calpain-like protein, putative 0.0751 0.226 0.3863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.052 0.2031
Schistosoma mansoni importin beta-1 0.0059 0.0099 0.0138
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0169 0.0238
Toxoplasma gondii histone deacetylase SIR2-like 0.0033 0.0016 0.0028
Brugia malayi Trypsin family protein 0.0082 0.0169 0.0169
Brugia malayi hypothetical protein 0.0041 0.004 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0033 0.0047
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0763 0.2298 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0158 0.0222
Echinococcus multilocularis transmembrane protease serine 3 0.0082 0.0169 0.0238
Plasmodium falciparum serine repeat antigen 8 0.0194 0.052 0.2263
Brugia malayi Proteasome A-type and B-type family protein 0.0167 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Echinococcus multilocularis Mastin 0.0082 0.0169 0.0238
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0041 0.004 0.0057
Echinococcus multilocularis calcium uptake protein 1 0.0099 0.0222 0.0311
Echinococcus granulosus neurogenic locus notch protein 0.0053 0.0081 0.0113
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.022 0.0602 0.1028
Leishmania major cathepsin L-like protease 0.0763 0.2298 0.3928
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.19 0.5851 0.8219
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0239 0.0431
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.004
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0033 0.0016 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0857 0.2591 0.364
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0076 0.015 0.021
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0125 0.0125
Mycobacterium tuberculosis Conserved protein 0.0078 0.0158 0.0275
Toxoplasma gondii centrin, putative 0.0098 0.022 0.0376
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0553 0.0945
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0069 0.0069
Echinococcus granulosus Dipeptidyl peptidase 9 0.0256 0.0715 0.1004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.052 0.2031
Brugia malayi aspartic protease BmAsp-2, identical 0.0041 0.004 0.004
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0069 0.0097
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.0027 0.0041
Leishmania major oligopeptidase b 0.0764 0.2301 0.3932
Onchocerca volvulus 0.0151 0.0384 0.0657
Echinococcus granulosus centrin 2 0.0098 0.022 0.0309
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Onchocerca volvulus Peroxidase homolog 0.0577 0.1716 0.2933
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0553 0.2159
Loa Loa (eye worm) hypothetical protein 0.0078 0.0158 0.0158
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.022 0.0602 0.0845
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0069 0.0097
Echinococcus multilocularis proteasome (prosome, macropain) 0.0167 0.0435 0.0611
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0041 0.004 0.004
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0127 0.0312 0.0438
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0751 0.226 0.3863
Brugia malayi Delta serrate ligand family protein 0.0053 0.0081 0.0081
Brugia malayi Pepsin A precursor 0.0041 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0081 0.0081
Brugia malayi prolyl oligopeptidase family protein 0.0212 0.0575 0.0575
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2306 0.712 1
Brugia malayi Trypsin family protein 0.0082 0.0169 0.0169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.052 0.0731
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0256 0.0715 0.1222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.2298 0.8974
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0888 0.0888
Echinococcus multilocularis calmodulin 0.0098 0.022 0.0309
Brugia malayi Cadherin domain containing protein 0.0053 0.0081 0.0081
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0082 0.0169 0.0238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.2298 0.8974
Loa Loa (eye worm) hypothetical protein 0.012 0.0289 0.0289
Entamoeba histolytica Ran family GTPase 0.0044 0.005 0.0217
Loa Loa (eye worm) hypothetical protein 0.0577 0.1716 0.1716
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0751 0.226 0.3175
Schistosoma mansoni rab 0.0098 0.022 0.0309
Schistosoma mansoni hypothetical protein 0.0036 0.0027 0.0037
Brugia malayi NAD-dependent deacetylase SIRT1 0.0141 0.0354 0.0354
Trypanosoma cruzi caltractin, putative 0.0098 0.022 0.0309
Echinococcus granulosus calpain 7 C02 family 0.0751 0.226 0.3175
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0141 0.0354 0.1383
Leishmania major calpain family cysteine protease-like protein 0.022 0.0602 0.1028
Entamoeba histolytica cysteine protease, putative 0.0194 0.052 0.2263
Brugia malayi calpain 5 0.022 0.0602 0.0602
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0158 0.0618

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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