Detailed information for compound 36696

Basic information

Technical information
  • TDR Targets ID: 36696
  • Name: 2-(6-methyl-4-oxo-2H-1,3-benzoxazin-3-yl)ethy l nitrate
  • MW: 252.223 | Formula: C11H12N2O5
  • H donors: 0 H acceptors: 3 LogP: 1.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)OCCN1COc2c(C1=O)cc(cc2)C
  • InChi: 1S/C11H12N2O5/c1-8-2-3-10-9(6-8)11(14)12(7-17-10)4-5-18-13(15)16/h2-3,6H,4-5,7H2,1H3
  • InChiKey: PRQKFPKMNWUHSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • nitric acid 2-(6-methyl-4-oxo-2H-1,3-benzoxazin-3-yl)ethyl ester
  • nitric acid 2-(4-keto-6-methyl-2H-1,3-benzoxazin-3-yl)ethyl ester
  • 143248-64-0
  • 6-Methyl-3-(2-(nitrooxy)ethyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one
  • 2-(6-Methyl-4-oxo-2H-1,3-benzoxazin-3(4H)-yl)ethyl nitrate
  • 6-Methyl-3-(2-nitroxyethyl)-2H-1,3-benzoxazin-4(3H)-one
  • 4H-1,3-Benzoxazin-4-one, 2,3-dihydro-6-methyl-3-(2-(nitrooxy)ethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2578 0.3439 0.3439
Loa Loa (eye worm) hypothetical protein 0.5514 0.7381 0.738
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0001 0.0001
Leishmania major oligopeptidase b 0.0456 0.0591 0.1606
Loa Loa (eye worm) hypothetical protein 0.0058 0.0056 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Trichomonas vaginalis calcium binding protein, putative 0.0366 0.047 0.1367
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0007 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0305 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0035
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0023 0.0068
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0829 0.1091 0.3174
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0233 0.0292 0.0291
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0015 0.0044
Giardia lamblia Proteasome subunit beta type 1 0.0063 0.0063 0.0182
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0138 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0075 0.0217
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0007 0.0019
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1034 0.1367 0.1366
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0004 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.0626 0.0818 0.0818
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Echinococcus multilocularis cathepsin L 0.0389 0.0501 0.0501
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1016 0.1343 0.1343
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0694 0.091 0.4097
Echinococcus multilocularis regulator of G protein signaling 3 0.0037 0.0029 0.0028
Toxoplasma gondii microneme protein MIC4 0.0028 0.0015 0.0044
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1016 0.1343 0.365
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Echinococcus granulosus cathepsin L cysteine protease 0.0694 0.091 0.091
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0031 0.0089
Onchocerca volvulus 0.0072 0.0075 0.0144
Brugia malayi Papain family cysteine protease containing protein 0.1142 0.1511 0.1511
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0018 0.0018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0004 0.0011
Entamoeba histolytica calpain large subunit domain III containing protein 0.1668 0.2217 1
Schistosoma mansoni gamma-secretase subunit aph-1 0.0256 0.0322 0.0322
Plasmodium falciparum plasmepsin IV 0.0017 0.0001 0.0005
Giardia lamblia Encystation-specific protease 0.0389 0.0501 0.1456
Brugia malayi cytochrome P450 0.0021 0.0006 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.004 0.004
Onchocerca volvulus 0.0072 0.0075 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0018 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.1142 0.1511 0.1511
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0018 0.0034
Entamoeba histolytica calmodulin, putative 0.0366 0.047 0.2108
Onchocerca volvulus 0.0043 0.0035 0.0067
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0138 0.234
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0093 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0099 0.0098
Mycobacterium ulcerans lipase LipD 0.0072 0.0075 0.1266
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0075 0.0075
Brugia malayi Cathepsin L-like precursor 0.0305 0.0388 0.0388
Brugia malayi nuclear hormone receptor 0.003 0.0018 0.0018
Trypanosoma cruzi I/6 autoantigen, putative 0.0366 0.047 0.047
Echinococcus multilocularis Regulator of G protein signaling 20 0.0037 0.0029 0.0028
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0018 0.0018
Trichomonas vaginalis calmodulin, putative 0.0366 0.047 0.1367
Loa Loa (eye worm) myosin regulatory light chain 1 0.0058 0.0056 0.0055
Schistosoma mansoni reticulocalbin 0.0371 0.0477 0.0477
Brugia malayi Trypsin-like protease protein 5 0.0043 0.0035 0.0035
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0043 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Onchocerca volvulus 0.0043 0.0035 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Schistosoma mansoni hypothetical protein 0.0048 0.0042 0.0042
Brugia malayi beta-lactamase family protein 0.0072 0.0075 0.0075
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0109 0.0125 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.014 0.014
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0029 0.0028
Loa Loa (eye worm) proteasome subunit beta type 2 0.0039 0.0031 0.003
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.6343 0.8494 0.8494
Onchocerca volvulus 0.1142 0.1511 0.2937
Loa Loa (eye worm) calpain family protein 1 0.4676 0.6255 0.6255
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0006 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0004 0.0004
Echinococcus multilocularis beta adrenergic receptor kinase 0.0037 0.0029 0.0028
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0006 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0002 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0018 0.0018
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0063 0.0063 0.0063
Schistosoma mansoni cathepsin s 0.0305 0.0388 0.0388
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0063 0.0063 0.0063
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0205 0.0253 0.0689
Mycobacterium tuberculosis Probable reductase 0.0107 0.0122 0.0901
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0006 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Onchocerca volvulus 0.1142 0.1511 0.2937
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.6709 0.8986 0.8986
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.2684 0.3582 0.9735
Trypanosoma brucei calpain-like protein, putative 0.2497 0.333 0.9052
Entamoeba histolytica grainin, putative 0.0371 0.0477 0.2139
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1269 0.1681 0.457
Onchocerca volvulus 0.0048 0.0042 0.008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.004 0.0039
Schistosoma mansoni centrin-related 0.0366 0.047 0.047
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0129 0.0151 0.0439
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.026 0.0327 0.0327
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0389 0.0501 0.2246
Mycobacterium tuberculosis Probable peptidase 0.0456 0.0591 0.4353
Leishmania major receptor-type adenylate cyclase a-like protein 0.0205 0.0253 0.0689
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0389 0.0501 0.0501
Plasmodium falciparum serine repeat antigen 8 0.0389 0.0501 0.3313
Trichomonas vaginalis calcineurin B subunit, putative 0.0371 0.0477 0.1387
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0389 0.0501 0.3313
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0018 0.0018
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0031 0.003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0018 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0004 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.1142 0.1511 0.681
Leishmania major proteasome beta 2 subunit, putative 0.0039 0.0031 0.0083
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0456 0.0591 0.0591
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0029 0.0028
Loa Loa (eye worm) ctsf protein 0.1142 0.1511 0.151
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0006 0.0103
Giardia lamblia Alanyl dipeptidyl peptidase 0.012 0.014 0.0406
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0004 0.0029
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0541 0.0704 0.0704
Entamoeba histolytica cysteine protease, putative 0.0389 0.0501 0.2246
Schistosoma mansoni cathepsin S (C01 family) 0.0389 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0028
Onchocerca volvulus Prolyl endopeptidase homolog 0.1147 0.1519 0.2952
Loa Loa (eye worm) hypothetical protein 0.0389 0.0501 0.05
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0006 0.0103
Trypanosoma brucei proteasome beta 6 subunit 0.0063 0.0063 0.017
Entamoeba histolytica calmodulin, putative 0.0058 0.0056 0.0238
Onchocerca volvulus Cathepsin L homolog 0.1142 0.1511 0.2937
Trypanosoma cruzi prolyl endopeptidase 0.1147 0.1519 0.1519
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0063 0.0063 0.0063
Echinococcus granulosus tumor protein p63 0.033 0.0422 0.0422
Toxoplasma gondii calcium-dependent protein kinase 0.0371 0.0477 0.1387
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0389 0.0501 0.3313
Leishmania major small myristoylated protein 4, putative 0.0557 0.0727 0.1975
Onchocerca volvulus 0.0703 0.0922 0.1791
Toxoplasma gondii aspartyl protease ASP1 0.0017 0.0001 0.0002
Brugia malayi Kringle domain containing protein 0.0043 0.0036 0.0036
Schistosoma mansoni calmodulin 0.0366 0.047 0.047
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0501 0.1456
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0014 0.0014
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0389 0.0501 0.1503
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0004 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0075 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0004 0.0003
Trypanosoma brucei Calpain-like protein CALP1.3 0.1034 0.1367 0.3714
Loa Loa (eye worm) hypothetical protein 0.0058 0.0056 0.0055
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0694 0.091 0.091
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0006 0.0045
Onchocerca volvulus 0.0043 0.0035 0.0067
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.2578 0.3439 0.9347
Echinococcus granulosus proteasome prosome macropain 0.0081 0.0087 0.0087
Brugia malayi EF hand family protein 0.0366 0.047 0.047
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0129 0.0151 0.0151
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0389 0.0501 0.1503
Trypanosoma brucei cysteine peptidase C (CPC) 0.2578 0.3439 0.9347
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.004 0.004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0305 0.0388 0.0387
Giardia lamblia Cathepsin B precursor 0.2578 0.3439 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.1034 0.1367 0.1366
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0018 0.0017
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0305 0.0388 0.0388
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0017 0.0001 0.0002
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.7465 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0023 0.0065
Echinococcus multilocularis axis inhibition protein axin 0.0037 0.0029 0.0028
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0063 0.0063 0.0063
Trypanosoma cruzi conserved protein 0.1043 0.1378 0.1378
Toxoplasma gondii hypothetical protein 0.0028 0.0015 0.0044
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0129 0.0151 0.0151
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0142 0.0169 0.0169
Echinococcus granulosus calmodulin 0.0366 0.047 0.047
Leishmania major protein kinase, putative 0.0366 0.047 0.1277
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1147 0.1519 0.4128
Toxoplasma gondii cathepsin B 0.2578 0.3439 1
Leishmania major phospholipase c-like protein 0.0366 0.047 0.1277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.0501 0.1456
Brugia malayi Cathepsin L-like precursor 0.1142 0.1511 0.1511
Schistosoma mansoni reticulocalbin 0.0366 0.047 0.047
Schistosoma mansoni hypothetical protein 0.0043 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0081 0.0087 0.0087
Entamoeba histolytica hypothetical protein, conserved 0.0371 0.0477 0.2139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0018 0.0018
Schistosoma mansoni intermediate filament proteins 0.0027 0.0014 0.0014
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.6709 0.8986 0.8986
Echinococcus multilocularis regulator of G protein signaling 0.0037 0.0029 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0099 0.0098
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0023 0.0065
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0129 0.0151 0.0439
Plasmodium falciparum serine repeat antigen 6 0.0389 0.0501 0.3313
Echinococcus multilocularis transmembrane protease serine 3 0.0043 0.0035 0.0035
Leishmania major small myristoylated protein-2 0.0644 0.0843 0.2292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0122 0.1987
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0039 0.0031 0.003
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0366 0.047 0.047
Plasmodium falciparum glutathione reductase 0.0047 0.0041 0.0273
Trypanosoma cruzi cysteine peptidase, putative 0.1378 0.1828 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0389 0.0501 0.1456
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0002 0.0001
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0371 0.0477 0.0477
Leishmania major centrin, putative 0.0366 0.047 0.1277
Onchocerca volvulus Cathepsin L homolog 0.0389 0.0501 0.0972
Echinococcus multilocularis musashi 0.0027 0.0014 0.0014
Echinococcus granulosus gamma secretase subunit aph 1 0.0256 0.0322 0.0322
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0389 0.0501 0.1503
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0006 0.0103
Loa Loa (eye worm) prolyl oligopeptidase 0.012 0.014 0.0139
Plasmodium vivax aspartyl protease, putative 0.0017 0.0001 0.0002
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0389 0.0501 0.2246
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0006 0.0006
Brugia malayi Cathepsin L-like cysteine proteinase 0.0837 0.1101 0.1101
Echinococcus multilocularis calpain 7 (C02 family) 0.2497 0.333 0.333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0501 0.1456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0018 0.0017
Schistosoma mansoni cpg binding protein 0.006 0.0059 0.0058
Schistosoma mansoni coup transcription factor 0.003 0.0018 0.0018
Trichomonas vaginalis calmodulin, putative 0.0366 0.047 0.1367
Echinococcus multilocularis proteasome (prosome, macropain) 0.0081 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0694 0.091 0.2647
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0029 0.0028
Echinococcus multilocularis cysteine protease 0.1142 0.1511 0.1511
Onchocerca volvulus 0.0028 0.0015 0.0028
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.2497 0.333 0.9052
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.012 0.014 0.014
Brugia malayi Cathepsin L-like precursor 0.1142 0.1511 0.1511
Loa Loa (eye worm) TK/ROR protein kinase 0.0043 0.0036 0.0035
Plasmodium falciparum peptidase, putative 0.012 0.014 0.0925
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0004 0.0004
Echinococcus granulosus EF hand domain containing family member A2 0.0366 0.047 0.047
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0081 0.0087 0.0253
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0075 0.1266
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0205 0.0253 0.0689
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0041 0.0124
Onchocerca volvulus 0.009 0.0099 0.019
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0037 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.012 0.014 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1142 0.1511 0.4394
Echinococcus multilocularis microtubule associated protein 2 0.1349 0.179 0.1789
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.026 0.0327 0.0889
Loa Loa (eye worm) hypothetical protein 0.0389 0.0501 0.05
Trypanosoma brucei Calpain-like protein 1.2 0.1177 0.1558 0.4235
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0075 0.0551
Schistosoma mansoni lamin 0.0027 0.0014 0.0014
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0018 0.0018
Loa Loa (eye worm) PXA domain-containing protein 0.0037 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.003
Trypanosoma brucei I/6 autoantigen 0.0366 0.047 0.1277
Brugia malayi cathepsin L-like precursor 0.0837 0.1101 0.1101
Mycobacterium ulcerans hypothetical protein 0.0072 0.0075 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.0083
Entamoeba histolytica cysteine protease, putative 0.0389 0.0501 0.2246
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0501 0.0501
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0058 0.0056 0.0169
Toxoplasma gondii EF hand domain-containing protein 0.0058 0.0056 0.0163
Trichomonas vaginalis calcium binding protein, putative 0.0424 0.0548 0.1594
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1177 0.1558 0.4235
Leishmania major hypothetical protein, conserved 0.0072 0.0075 0.0203
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0081 0.0087 0.064
Leishmania major trypanothione reductase 0.0047 0.0041 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0332 0.0424 0.0424
Brugia malayi NAD-dependent deacetylase SIRT1 0.0142 0.0169 0.0169
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0035
Leishmania major calcineurin B subunit, putative 0.0366 0.047 0.1277
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.1034 0.1367 0.1366
Echinococcus granulosus acylamino acid releasing enzyme 0.012 0.014 0.014
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0122 0.0901
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0366 0.047 0.1277
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.03 0.038 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0694 0.091 0.2474
Echinococcus multilocularis EF hand domain containing family member A2 0.0366 0.047 0.047
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0006 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0099 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0075 0.0217
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0039 0.0031 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0018 0.0017
Trypanosoma brucei calpain, putative 0.1089 0.144 0.3915
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0501 0.1456
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0122 0.0901
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0006 0.0045
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0033 0.0023 0.0061
Loa Loa (eye worm) hypothetical protein 0.0316 0.0402 0.0401
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0002 0.0001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.03 0.038 0.038
Giardia lamblia Alanyl dipeptidyl peptidase 0.012 0.014 0.0406
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0837 0.1101 0.1101
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0023 0.0023
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0006 0.0103
Plasmodium falciparum serine repeat antigen 2 0.0389 0.0501 0.3313
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.026 0.0327 0.0889
Leishmania major hypothetical protein, conserved 0.0332 0.0424 0.1153
Plasmodium vivax hypothetical protein, conserved 0.012 0.014 0.0419
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.002 0.0059
Trichomonas vaginalis centrin, putative 0.0366 0.047 0.1367
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0253 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Brugia malayi calpain D 0.0829 0.1091 0.1091
Trichomonas vaginalis conserved hypothetical protein 0.0366 0.047 0.1367
Trichomonas vaginalis calcium binding protein, putative 0.0366 0.047 0.1367
Onchocerca volvulus 0.003 0.0018 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Onchocerca volvulus 0.1142 0.1511 0.2937
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0004 0.001
Brugia malayi programmed cell death protein 6 0.0366 0.047 0.047
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0037 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.0075 0.0074
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0015 0.0015
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0694 0.091 0.091
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.2497 0.333 0.333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.006 0.0059 0.0058
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0292 0.0291
Plasmodium falciparum cysteine proteinase falcipain 1 0.0694 0.091 0.6024
Trypanosoma brucei conserved protein 0.0214 0.0265 0.0721
Plasmodium vivax calpain, putative 0.2497 0.333 1
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0292 0.0291
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0004 0.0004
Echinococcus multilocularis caspase 2 0.003 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.1043 0.1378 0.3747
Trypanosoma brucei unspecified product 0.0205 0.0253 0.0689
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Loa Loa (eye worm) trypsin family protein 0.0043 0.0035 0.0035
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0043 0.0035 0.0035
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0366 0.047 0.1411
Plasmodium vivax aspartyl protease, putative 0.0017 0.0001 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0014 0.0013
Echinococcus multilocularis calpain family protein 1, d 0.4676 0.6255 0.6255
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0018 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0041 0.004
Onchocerca volvulus 0.0072 0.0075 0.0144
Trypanosoma cruzi oligopeptidase b 0.0456 0.0591 0.0591
Echinococcus granulosus Calcium binding protein 0.0058 0.0056 0.0056
Echinococcus granulosus neuronal calcium sensor 0.0366 0.047 0.047
Plasmodium vivax proteasome subunit beta type-5, putative 0.0081 0.0087 0.0261
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0366 0.047 0.1367
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0694 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0389 0.0501 0.05
Entamoeba histolytica cysteine proteinase 1, putative 0.0694 0.091 0.4097
Schistosoma mansoni neuronal calcium sensor 0.0366 0.047 0.047
Entamoeba histolytica calpain family cysteine protease, putative 0.0829 0.1091 0.4915
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.2684 0.3582 0.3581
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0039 0.0031 0.0031
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0081 0.0087 0.1382
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.004 0.004
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0006 0.0045
Giardia lamblia Cathepsin B precursor 0.0389 0.0501 0.1456
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.137 0.1817 0.1817
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.0112 0.0112
Leishmania major hypothetical protein, conserved 0.0371 0.0477 0.1296
Echinococcus multilocularis geminin 0.0334 0.0427 0.0427
Entamoeba histolytica cysteine protease, putative 0.0389 0.0501 0.2246
Echinococcus multilocularis tissue type plasminogen activator 0.0043 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0366 0.047 0.0469
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0075 0.0075
Echinococcus granulosus bloom syndrome protein 0.0021 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0004 0.0011
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0029 0.0028
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0006 0.0103
Plasmodium vivax proteasome subunit beta type-1, putative 0.0063 0.0063 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Schistosoma mansoni cathepsin F (C01 family) 0.0837 0.1101 0.1101
Echinococcus multilocularis acylamino acid releasing enzyme 0.012 0.014 0.014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0954 0.1259 0.1259
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0006 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0501 0.1456
Toxoplasma gondii cathepsin CPC2 0.0389 0.0501 0.1456
Trypanosoma brucei cysteine peptidase, putative 0.1034 0.1367 0.3714
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0389 0.0501 0.0501
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.012 0.014 0.014
Brugia malayi EF hand family protein 0.0371 0.0477 0.0477
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0389 0.0501 0.1456
Schistosoma mansoni memapsin-2 (A01 family) 0.0421 0.0543 0.0543
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0041 0.0041
Plasmodium vivax vivapain-3 0.0694 0.091 0.2733
Echinococcus granulosus centrin 2 0.0366 0.047 0.047
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0033 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Entamoeba histolytica hypothetical protein 0.0037 0.0029 0.0113
Trypanosoma brucei calmodulin, putative 0.0366 0.047 0.1277
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0015 0.0015
Onchocerca volvulus 0.0028 0.0015 0.0028
Echinococcus multilocularis calpain 0.2497 0.333 0.333
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0042
Brugia malayi Trypsin family protein 0.0043 0.0035 0.0035
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0004 0.0011
Mycobacterium ulcerans Sir2-like regulatory protein 0.0033 0.0023 0.0381
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0138 0.2262
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0015 0.0044
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.137 0.1817 0.494
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1327 0.176 0.4784
Trichomonas vaginalis calcium binding proteins, putative 0.0366 0.047 0.1367
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0099 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0837 0.1101 0.3203
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0018 0.0018
Giardia lamblia Cathepsin B precursor 0.2578 0.3439 1
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.026 0.0327 0.0889
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0075 0.0551
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Brugia malayi Pepsin A precursor 0.0017 0.0001 0.0001
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.012 0.014 0.038
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0146 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0012 0.0012
Trypanosoma cruzi cysteine proteinase, putative 0.0694 0.091 0.091
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0004 1
Schistosoma mansoni microtubule-associated protein tau 0.1349 0.179 0.1789
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0138 0.0376
Brugia malayi Cathepsin L-like precursor 0.1142 0.1511 0.1511
Echinococcus multilocularis enteropeptidase 0.0043 0.0035 0.0035
Plasmodium falciparum plasmepsin VII 0.0017 0.0001 0.0005
Giardia lamblia Cysteine protease 0.0389 0.0501 0.1456
Brugia malayi intermediate filament protein 0.0027 0.0014 0.0014
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0366 0.047 0.1367
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0018 0.0018
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1177 0.1558 0.1558
Trypanosoma cruzi unspecified product 0.0354 0.0453 0.0453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0389 0.0501 0.1456
Echinococcus multilocularis inhibitor of apoptosis protein 0.0039 0.0031 0.0031
Leishmania major calpain protease-like protein 0.0829 0.1091 0.2966
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0003
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1327 0.176 0.4784
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0205 0.0253 0.0253
Brugia malayi Cytochrome P450 family protein 0.0047 0.0041 0.0041
Trypanosoma brucei prolyl oligopeptidase, putative 0.0456 0.0591 0.1606
Schistosoma mansoni calpain-7 (C02 family) 0.2497 0.333 0.333
Brugia malayi Cathepsin L-like precursor 0.0837 0.1101 0.1101
Brugia malayi Thioredoxin reductase 0.0047 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0366 0.047 0.047
Brugia malayi Myosin regulatory light chain 1 0.0058 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0028
Toxoplasma gondii microneme protein MIC17B 0.0028 0.0015 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0018 0.0018
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0456 0.0591 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1089 0.144 0.3915
Loa Loa (eye worm) calpain 0.2497 0.333 0.3329
Trichomonas vaginalis kakapo, putative 0.0058 0.0056 0.0163
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1327 0.176 0.4784
Echinococcus multilocularis lamin 0.0027 0.0014 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0029 0.0028
Entamoeba histolytica calcium-binding protein, putative 0.0366 0.047 0.2108
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.6709 0.8986 0.8986
Echinococcus granulosus calbindin 32 0.0371 0.0477 0.0477
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0039 0.0031 0.003
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0389 0.0501 0.05
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0000052937
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1142 0.1511 0.1511
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.012 0.014 0.038
Echinococcus granulosus lamin 0.0027 0.0014 0.0014
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0035
Loa Loa (eye worm) RecQ helicase 0.0021 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0389 0.0501 0.05
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0006 0.0103
Trypanosoma brucei kinesin, putative 0.1668 0.2217 0.6026
Onchocerca volvulus 0.1142 0.1511 0.2937
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0501 0.1456
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0029 0.0028
Echinococcus multilocularis calumenin 0.0371 0.0477 0.0477
Onchocerca volvulus 0.0043 0.0035 0.0067
Toxoplasma gondii cathepsin CPL 0.1142 0.1511 0.4394
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0004 0.0004
Brugia malayi Pre-SET motif family protein 0.0617 0.0807 0.0807
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.001
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0006 0.0005
Echinococcus granulosus prolyl endopeptidase 0.1147 0.1519 0.1519
Toxoplasma gondii hypothetical protein 0.012 0.014 0.0406
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0006 0.0045
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.2757 0.3679 1
Echinococcus granulosus Mastin 0.0043 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0039 0.0031 0.0089
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0129 0.0151 0.0666
Brugia malayi Protein kinase domain containing protein 0.0043 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0035
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0015 0.0044
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0058 0.0056 0.0163
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0142 0.0169 0.0492
Loa Loa (eye worm) hypothetical protein 0.3846 0.5142 0.5142
Trichomonas vaginalis conserved hypothetical protein 0.012 0.014 0.0406
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0256 0.0322 0.0321
Loa Loa (eye worm) hypothetical protein 0.0837 0.1101 0.1101
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0018 0.0018
Plasmodium falciparum plasmepsin V 0.0017 0.0001 0.0005
Schistosoma mansoni chromatin regulatory protein sir2 0.0129 0.0151 0.0151
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0006 0.0103
Echinococcus granulosus regulator of G protein signaling 3 0.0037 0.0029 0.0028
Giardia lamblia Cathepsin L-like protease 0.0389 0.0501 0.1456
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0253 0.0253
Plasmodium vivax plasmepsin V, putative 0.0017 0.0001 0.0002
Brugia malayi ecdysteroid receptor 0.003 0.0018 0.0018
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0389 0.0501 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0075 0.0217
Trichomonas vaginalis calpain, putative 0.0829 0.1091 0.3174
Trypanosoma cruzi cruzipain precursor, putative 0.1378 0.1828 0.1828
Onchocerca volvulus 0.0028 0.0015 0.0028
Schistosoma mansoni myosin regulatory light chain 0.0058 0.0056 0.0056
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0694 0.091 0.2647
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0041 0.004
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0389 0.0501 0.1503
Brugia malayi Papain family cysteine protease containing protein 0.0694 0.091 0.091
Onchocerca volvulus 0.0039 0.0031 0.0058
Schistosoma mansoni hypothetical protein 0.0409 0.0528 0.0528
Plasmodium falciparum serine repeat antigen 4 0.0389 0.0501 0.3313
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0038 0.0103
Trichomonas vaginalis calmodulin, putative 0.0366 0.047 0.1367
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0081 0.0087 0.0253
Brugia malayi calpain family protein 1 0.6343 0.8494 0.8494
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0389 0.0501 0.05
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0837 0.1101 0.1101
Leishmania major cathepsin L-like protease 0.1142 0.1511 0.4107
Trypanosoma brucei caltractin, putative 0.0424 0.0548 0.149
Schistosoma mansoni axis inhibition protein axin 0.0037 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0829 0.1091 0.1091
Brugia malayi hypothetical protein 0.003 0.0018 0.0018
Mycobacterium leprae Probable lipase LipE 0.0072 0.0075 0.1175
Entamoeba histolytica cysteine protease, putative 0.1142 0.1511 0.681
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0389 0.0501 0.1503
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0013
Loa Loa (eye worm) glutathione reductase 0.0047 0.0041 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0012 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0041 0.0041
Echinococcus granulosus transmembrane protease serine 3 0.0043 0.0035 0.0035
Plasmodium falciparum plasmepsin II 0.0017 0.0001 0.0005
Echinococcus granulosus calpain 0.2497 0.333 0.333
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0389 0.0501 0.0501
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0006 0.0103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0028
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0004 1
Brugia malayi beta-lactamase family protein 0.0072 0.0075 0.0075
Echinococcus granulosus Myosin regulatory light chain 0.0058 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0501 0.1456
Trypanosoma cruzi calmodulin, putative 0.0366 0.047 0.047
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0006 0.0018
Trichomonas vaginalis calmodulin, putative 0.0058 0.0056 0.0163
Echinococcus multilocularis tumor protein p63 0.033 0.0422 0.0422
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.026 0.0327 0.0889
Echinococcus granulosus glycoprotein Antigen 5 0.0043 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Leishmania major calpain family cysteine protease-like protein 0.1034 0.1367 0.3714
Echinococcus multilocularis hypothetical protein 0.2497 0.333 0.333
Trichomonas vaginalis conserved hypothetical protein 0.0829 0.1091 0.3174
Echinococcus multilocularis cysteine protease 0.1142 0.1511 0.1511
Brugia malayi Trypsin family protein 0.0043 0.0035 0.0035
Plasmodium vivax aspartyl protease, putative 0.0017 0.0001 0.0002
Echinococcus granulosus axis inhibition protein axin 0.0037 0.0029 0.0028
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0033 0.0023 0.0023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0018 0.0018
Brugia malayi regulator of G-protein signaling egl-10 0.0037 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.0083
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.0186 0.0186
Onchocerca volvulus 0.0028 0.0015 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.7465 1 1
Brugia malayi Trypsin family protein 0.0043 0.0035 0.0035
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0023 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.0837 0.1101 0.496
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0006 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0006 0.0045
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0829 0.1091 0.2966
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.2757 0.3679 0.3679
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.1034 0.1367 0.3714
Brugia malayi Regulator of G protein signaling domain containing protein 0.0037 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0305 0.0388 0.0387
Plasmodium falciparum centrin-4 0.0058 0.0056 0.0372
Trypanosoma brucei centrin, putative 0.0366 0.047 0.1277
Onchocerca volvulus 0.0028 0.0015 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0006 0.0045
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0063 0.0063 0.0182
Toxoplasma gondii kringle domain-containing protein 0.0043 0.0036 0.0104
Onchocerca volvulus 0.0043 0.0035 0.0067
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0389 0.0501 0.1456
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.012 0.014 0.0406
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0018 0.0034
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0043 0.0035 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0371 0.0477 0.1432
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0138 0.0138
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0075 0.0551
Echinococcus multilocularis regulator of G protein signaling 3 0.0037 0.0029 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0006 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0389 0.0501 0.1456
Echinococcus granulosus intermediate filament protein 0.0027 0.0014 0.0014
Echinococcus multilocularis calcium uptake protein 1 0.0371 0.0477 0.0477
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0366 0.047 0.047
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0018 0.0018
Trypanosoma brucei hypothetical protein 0.1089 0.144 0.3915
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0058 0.0056 0.0055
Schistosoma mansoni neuronal calcium sensor 0.0366 0.047 0.047
Brugia malayi Papain family cysteine protease containing protein 0.0389 0.0501 0.0501
Mycobacterium tuberculosis Conserved protein 0.0072 0.0075 0.0551
Trichomonas vaginalis calcium binding protein, putative 0.0058 0.0056 0.0163
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0075 0.0551
Plasmodium vivax unspecified product 0.0389 0.0501 0.1503
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0389 0.0501 0.1456
Trypanosoma cruzi cysteine peptidase, putative 0.1378 0.1828 0.1828
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0041 0.0041
Brugia malayi cathepsin L-like cysteine proteinase 0.0389 0.0501 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0018 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0012 0.0078
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.137 0.1817 0.1817
Echinococcus granulosus expressed protein 0.073 0.0958 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Schistosoma mansoni chromatin regulatory protein sir2 0.0129 0.0151 0.0151
Trichomonas vaginalis hypothetical protein 0.0829 0.1091 0.3174
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0253 0.0253
Plasmodium vivax serine-repeat antigen (SERA) 0.0389 0.0501 0.1503
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0037 0.0029 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0029 0.0028
Echinococcus multilocularis dna polymerase eta 0.0045 0.0038 0.0038
Entamoeba histolytica cysteine proteinase 2 0.0694 0.091 0.4097
Giardia lamblia Cathepsin L precursor 0.0389 0.0501 0.1456
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.012 0.014 0.014
Toxoplasma gondii prolyl endopeptidase 0.1147 0.1519 0.4417
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0205 0.0253 0.0689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1142 0.1511 1
Echinococcus granulosus programmed cell death protein 6 0.0063 0.0063 0.0063
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0037 0.0029 0.0028
Trypanosoma brucei calpain-like protein, putative 0.2497 0.333 0.9052
Plasmodium vivax centrin-1, putative 0.0366 0.047 0.1411
Loa Loa (eye worm) hypothetical protein 0.009 0.0099 0.0098
Brugia malayi hypothetical protein 0.0037 0.0029 0.0029
Plasmodium falciparum serine repeat antigen 7 0.0389 0.0501 0.3313
Trypanosoma cruzi centrin-3 0.0424 0.0548 0.0548
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0075 0.0551
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.004 0.004
Trichomonas vaginalis calmodulin-2, putative 0.0366 0.047 0.1367
Giardia lamblia Cathepsin B precursor 0.0389 0.0501 0.1456
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0138 0.1019
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0366 0.047 0.047
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0829 0.1091 0.3174
Brugia malayi Papain family cysteine protease containing protein 0.0389 0.0501 0.0501
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0829 0.1091 0.3174
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1089 0.144 0.3915
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0042 0.0042
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.012 0.014 0.014
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0006 0.0103
Loa Loa (eye worm) hypothetical protein 0.0072 0.0075 0.0074
Echinococcus granulosus enteropeptidase 0.0043 0.0035 0.0035
Mycobacterium tuberculosis Possible penicillin-binding protein 0.046 0.0596 0.4389
Echinococcus multilocularis calmodulin 0.0366 0.047 0.047
Plasmodium falciparum plasmepsin VI 0.0017 0.0001 0.0005
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0205 0.0253 0.0689
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0501 0.1456
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0006 0.0045
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0006 0.0103
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0075 0.0551
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1016 0.1343 0.365
Giardia lamblia Cathepsin L precursor 0.0389 0.0501 0.1456
Schistosoma mansoni calpain-2 (C02 family) 0.0829 0.1091 0.1091
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.0029 0.0028
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.7465 1 1
Brugia malayi prolyl oligopeptidase family protein 0.012 0.014 0.014
Trypanosoma cruzi kinesin, putative 0.1668 0.2217 0.2217
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0039 0.0031 0.0202
Leishmania major calmodulin-like protein 0.0366 0.047 0.1277
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Trypanosoma brucei centrin, putative 0.0366 0.047 0.1277
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0829 0.1091 0.3174
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0389 0.0501 0.0501
Schistosoma mansoni cathepsin C 0.0389 0.0501 0.0501
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0014 0.0013
Schistosoma mansoni mitochondrial solute carrier 0.0366 0.047 0.047
Echinococcus granulosus caspase 2 0.003 0.0018 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Leishmania major centrin, putative,caltractin, putative 0.0366 0.047 0.1277
Echinococcus granulosus cathepsin b 0.7465 1 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0037 0.0029 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0004 0.0011
Brugia malayi Neuronal calcium sensor family protein 1 0.0058 0.0056 0.0056
Echinococcus granulosus inhibitor of apoptosis protein 0.0039 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0829 0.1091 0.3174
Brugia malayi calpain 5 0.0829 0.1091 0.1091
Entamoeba histolytica grainin 2 0.0424 0.0548 0.2461
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0456 0.0591 0.1606
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.0501 0.1456
Onchocerca volvulus 0.1142 0.1511 0.2937
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0039 0.0031 0.0031
Schistosoma mansoni myosin regulatory light chain 0.0058 0.0056 0.0056
Toxoplasma gondii subtilisin SUB12 0.0028 0.0015 0.0044
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0023 0.0022
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0006 0.0103
Brugia malayi hypothetical protein 0.0037 0.0029 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0018 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0142 0.0169 0.0492
Toxoplasma gondii PAN/Apple domain-containing protein 0.0028 0.0015 0.0044
Onchocerca volvulus 0.0148 0.0177 0.0342
Brugia malayi regulator of G-protein signaling rgs-7 0.0037 0.0029 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0018 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.1378 0.1828 0.1828
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0006 0.0103
Schistosoma mansoni hypothetical protein 0.0334 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.6343 0.8494 0.8494
Echinococcus granulosus lamin dm0 0.0027 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1016 0.1343 0.1343
Giardia lamblia Cysteine protease 0.0389 0.0501 0.1456
Giardia lamblia Transcriptional regulator, Sir2 family 0.0033 0.0023 0.0065
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0004 0.0066
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0001 0.0001
Echinococcus granulosus Dipeptidyl peptidase 9 0.012 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.4676 0.6255 0.6255
Giardia lamblia Cysteine protease 0.0389 0.0501 0.1456
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Plasmodium vivax SET domain protein, putative 0.009 0.0099 0.0295
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0138 0.0138
Trypanosoma brucei small myristoylated protein 1-2 0.0354 0.0453 0.1231
Entamoeba histolytica cysteine protease, putative 0.0389 0.0501 0.2246
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.7465 1 1
Trypanosoma brucei Aph-1 protein, putative 0.01 0.0112 0.0304
Onchocerca volvulus 0.0837 0.1101 0.214
Echinococcus granulosus calpain 5 0.2497 0.333 0.333
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.1034 0.1367 0.3714
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0081 0.0087 0.0087
Schistosoma mansoni nuclear hormone receptor 0.003 0.0018 0.0018
Entamoeba histolytica dipeptidyl-peptidase, putative 0.012 0.014 0.0616
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Giardia lamblia Cathepsin B precursor 0.2578 0.3439 1
Brugia malayi Cell death protein 3 precursor 0.003 0.0018 0.0018
Trichomonas vaginalis esterase, putative 0.0072 0.0075 0.0217
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0142 0.0169 0.0492
Echinococcus multilocularis Dipeptidyl peptidase 9 0.012 0.014 0.014
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0006 0.0103
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0081 0.0087 0.0086
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0389 0.0501 0.3313
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0015 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0004 0.0009
Toxoplasma gondii centrin, putative 0.0366 0.047 0.1367
Echinococcus granulosus cathepsin L 0.0389 0.0501 0.0501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0012 0.0035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1034 0.1367 0.1366
Trypanosoma brucei calpain, putative 0.0829 0.1091 0.2966
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0037 0.0029 0.0028
Trypanosoma cruzi cysteine proteinase, putative 0.0694 0.091 0.091
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0456 0.0591 1
Trichomonas vaginalis calmodulin, putative 0.0424 0.0548 0.1594
Schistosoma mansoni cpg binding protein 0.006 0.0059 0.0058
Brugia malayi cathepsin F-like cysteine proteinase 0.0305 0.0388 0.0388
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0018 0.0018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0075 0.0074
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0006 0.0103
Trypanosoma brucei mitochondrial calcium uptake 1 0.0366 0.047 0.1277
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0037 0.0029 0.0028
Leishmania major cathepsin L-like protease 0.1378 0.1828 0.497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0389 0.0501 0.1456
Trypanosoma brucei antigen, putative 0.2497 0.333 0.9052
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0015 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Loa Loa (eye worm) EF hand family protein 0.0366 0.047 0.0469
Echinococcus granulosus cysteine protease 0.0694 0.091 0.091
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0018 0.0018
Echinococcus granulosus microtubule associated protein 2 0.1349 0.179 0.1789
Onchocerca volvulus 0.0043 0.0035 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0054 0.0053
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0004 0.0003
Brugia malayi cathepsin Z-like cysteine proteinase 0.0389 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Echinococcus granulosus calcyphosin protein 0.0058 0.0056 0.0056
Echinococcus granulosus cathepsin L cysteine proteinase 0.1142 0.1511 0.1511
Schistosoma mansoni lamin 0.0027 0.0014 0.0014
Echinococcus multilocularis 0.0021 0.0006 0.0006
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0366 0.047 0.2108
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0004 0.0004
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0006 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0018 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0144 0.0144
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0039 0.0031 0.0122
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0829 0.1091 0.3174
Giardia lamblia Hypothetical protein 0.0129 0.0151 0.0439
Echinococcus multilocularis neurocalcin 0.0366 0.047 0.047
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) cathepsin B 0.2578 0.3439 0.3438
Brugia malayi nuclear receptor NHR-88 0.003 0.0018 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0075 0.0551
Leishmania major programmed cell death 6 protein-like protein 0.0366 0.047 0.1277
Echinococcus multilocularis lamin dm0 0.0027 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.1147 0.1519 0.1518
Giardia lamblia Cathepsin L-like protease 0.0389 0.0501 0.1456
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1034 0.1367 0.1366
Leishmania major kinesin, putative 0.1668 0.2217 0.6026
Onchocerca volvulus 0.0028 0.0015 0.0028
Mycobacterium ulcerans beta-lactamase 0.0072 0.0075 0.1266
Loa Loa (eye worm) hypothetical protein 0.1142 0.1511 0.151
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.012 0.014 0.014
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0033 0.0023 0.0023
Toxoplasma gondii cathepsin CPC1 0.0389 0.0501 0.1456
Echinococcus granulosus regulator of G protein signaling 7 0.0037 0.0029 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0694 0.091 0.4097
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0081 0.0087 0.0087
Trypanosoma brucei Calpain-like protein 1.1 0.137 0.1817 0.494
Schistosoma mansoni inhibitor of apoptosis protein 0.0039 0.0031 0.0031
Echinococcus multilocularis axis inhibition protein axin 0.0037 0.0029 0.0028
Schistosoma mansoni calpain (C02 family) 0.2497 0.333 0.333
Onchocerca volvulus 0.0028 0.0015 0.0028
Trypanosoma brucei oligopeptidase b 0.0456 0.0591 0.1606
Brugia malayi prolyl oligopeptidase family protein 0.012 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0334 0.0427 0.0427
Schistosoma mansoni regulator of G protein signaling 0.0037 0.0029 0.0028
Echinococcus multilocularis cathepsin L cysteine protease 0.1142 0.1511 0.1511
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0075 0.0203
Leishmania major hypothetical protein, conserved 0.0205 0.0253 0.0689
Entamoeba histolytica hypothetical protein 0.0037 0.0029 0.0113
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0205 0.0253 0.0253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0694 0.091 0.2474
Toxoplasma gondii centrin family protein 0.0058 0.0056 0.0163
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0043 0.0043
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0041 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0018 0.0018
Plasmodium falciparum centrin-1 0.0366 0.047 0.3111
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0122 0.0901
Toxoplasma gondii microneme protein MIC17C 0.0028 0.0015 0.0044
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1145 0.1515 0.4118
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1142 0.1511 0.1511
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0018 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0557 0.0727 0.0726
Plasmodium falciparum serine repeat antigen 3 0.0389 0.0501 0.3313
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0501 0.0501
Plasmodium falciparum plasmepsin I 0.0017 0.0001 0.0005
Onchocerca volvulus 0.0371 0.0477 0.0926
Brugia malayi Cytochrome P450 family protein 0.0047 0.0041 0.0041
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1034 0.1367 0.1366
Loa Loa (eye worm) calmodulin-like protein 0.0366 0.047 0.0469
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0004 0.0011
Trichomonas vaginalis centrin, putative 0.0058 0.0056 0.0163
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1142 0.1511 0.151
Brugia malayi hypothetical protein 0.0043 0.0035 0.0035
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0007 0.0007
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0003 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0075 0.0075
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.0112 0.0112
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0039 0.0031 0.0031
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0063 0.0063 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0018 0.0018
Trypanosoma cruzi small myristoylated protein 1-1 0.0354 0.0453 0.0453
Trypanosoma brucei hypothetical protein, conserved 0.0332 0.0424 0.1153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.7465 1 1
Onchocerca volvulus 0.0043 0.0036 0.0068
Plasmodium vivax vivapain-2 0.1142 0.1511 0.4537
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0033 0.0023 0.0166
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0072 0.0075 0.0074
Schistosoma mansoni cathepsin F (C01 family) 0.1142 0.1511 0.1511
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1147 0.1519 0.1519
Giardia lamblia DINP protein human, muc B family 0.0019 0.0004 0.0011
Schistosoma mansoni calmodulin related calcium binding protein 0.0366 0.047 0.047
Toxoplasma gondii centrin 0.0366 0.047 0.1367
Loa Loa (eye worm) hypothetical protein 0.0072 0.0075 0.0074
Echinococcus granulosus dna polymerase kappa 0.0019 0.0004 0.0004
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0018 0.0018
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.2497 0.333 0.333
Brugia malayi prolyl oligopeptidase family protein 0.012 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0072 0.0075 0.0074
Schistosoma mansoni hypothetical protein 0.0021 0.0006 0.0006
Onchocerca volvulus 0.0058 0.0056 0.0108
Schistosoma mansoni cathepsin F (C01 family) 0.1142 0.1511 0.1511
Loa Loa (eye worm) transcriptional regulator 0.0129 0.0151 0.015
Trypanosoma cruzi kinesin, putative 0.1668 0.2217 0.2217
Schistosoma mansoni centrin 0.0366 0.047 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0056 0.0163
Brugia malayi hypothetical protein 0.0121 0.0141 0.0141
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0004 0.0003
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.012 0.014 0.0406
Entamoeba histolytica cysteine protease, putative 0.0389 0.0501 0.2246
Mycobacterium ulcerans NAD-dependent deacetylase 0.0033 0.0023 0.0381
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0081 0.0087 0.0377
Brugia malayi cathepsin L precursor 0.0389 0.0501 0.0501
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.001
Toxoplasma gondii microneme protein, putative 0.0028 0.0015 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.0083
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0037 0.0029 0.0028
Trichomonas vaginalis centrin, putative 0.0058 0.0056 0.0163
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0366 0.047 0.047
Leishmania major cytochrome p450-like protein 0.0021 0.0006 0.0016
Onchocerca volvulus 0.0057 0.0054 0.0104
Brugia malayi Cytochrome P450 family protein 0.0077 0.0081 0.0081
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0043 0.0036 0.0107
Giardia lamblia Cathepsin L precursor 0.0389 0.0501 0.1456
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0077 0.0076
Leishmania major cathepsin L-like protease 0.1142 0.1511 0.4107
Echinococcus multilocularis expressed protein 0.073 0.0958 0.0958
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Giardia lamblia Cathepsin L precursor 0.0389 0.0501 0.1456
Plasmodium vivax NAD-dependent deacetylase, putative 0.0033 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0148 0.0177 0.0176
Entamoeba histolytica hypothetical protein 0.0389 0.0501 0.2246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0018 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0018 0.0018
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0033 0.0023 0.0086
Onchocerca volvulus 0.0027 0.0014 0.0026
Entamoeba histolytica dipeptidyl-peptidase, putative 0.012 0.014 0.0616
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0389 0.0501 0.1456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Leishmania major hypothetical protein, conserved 0.0205 0.0253 0.0689
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0028
Brugia malayi Pre-SET motif family protein 0.009 0.0099 0.0099
Echinococcus multilocularis centrin 2 0.0366 0.047 0.047
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0023 0.0086
Trichomonas vaginalis calpain, putative 0.0829 0.1091 0.3174
Schistosoma mansoni hypothetical protein 0.0366 0.047 0.047
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0186 0.0186
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0138 0.0402
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.0001 0.0002
Loa Loa (eye worm) beta-lactamase 0.0072 0.0075 0.0074
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0015 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0829 0.1091 0.3174
Brugia malayi Cathepsin L-like precursor 0.1142 0.1511 0.1511
Echinococcus granulosus calpain 7 C02 family 0.2497 0.333 0.333
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0006 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.137 0.1817 0.494
Onchocerca volvulus Cathepsin L homolog 0.1142 0.1511 0.2937
Loa Loa (eye worm) hypothetical protein 0.0305 0.0388 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.004 0.004
Trichomonas vaginalis caltractin, putative 0.0058 0.0056 0.0163
Plasmodium vivax plasmepsin IV, putative 0.0017 0.0001 0.0002
Brugia malayi gamma-secretase subunit aph-1 0.0256 0.0322 0.0322
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0006 0.0103
Brugia malayi hypothetical protein 0.0025 0.0012 0.0012
Plasmodium falciparum serine repeat antigen 5 0.0389 0.0501 0.3313
Echinococcus multilocularis calmodulin 0.0366 0.047 0.047
Echinococcus multilocularis EF hand domain containing family member A2 0.0371 0.0477 0.0477
Toxoplasma gondii EFHC1, putative 0.0366 0.047 0.1367
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.137 0.1817 0.494
Trypanosoma brucei Calpain-like protein 2 0.1159 0.1534 0.417
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.012 0.014 0.038
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0056 0.0056
Echinococcus granulosus cathepsin l1 0.1142 0.1511 0.1511
Entamoeba histolytica prolyl oligopeptidase family protein 0.012 0.014 0.0616
Loa Loa (eye worm) calpain family protein 1 0.6343 0.8494 0.8494
Entamoeba histolytica protein kinase, putative 0.1668 0.2217 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.0083
Echinococcus granulosus EF HAND 1 calcium binding site 0.0366 0.047 0.047
Brugia malayi transcriptional regulator, Sir2 family protein 0.0129 0.0151 0.0151
Brugia malayi PXA domain containing protein 0.0037 0.0029 0.0029
Entamoeba histolytica prolyl oligopeptidase family protein 0.012 0.014 0.0616
Onchocerca volvulus 0.0028 0.0015 0.0028
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0004 0.0066
Brugia malayi Cathepsin L-like precursor 0.1142 0.1511 0.1511
Echinococcus multilocularis regulator of G protein signaling 7 0.0037 0.0029 0.0028
Toxoplasma gondii preprocathepsin c precursor, putative 0.0389 0.0501 0.1456
Onchocerca volvulus Deterin homolog 0.0039 0.0031 0.0058
Echinococcus granulosus cathepsin l1 0.0837 0.1101 0.1101
Brugia malayi steroid hormone receptor 0.003 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0389 0.0501 0.1503
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0004 0.0057
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.0528 0.0528
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0456 0.0591 0.1606
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0037 0.0029 0.0028
Plasmodium falciparum thioredoxin reductase 0.0047 0.0041 0.0273
Plasmodium falciparum calpain 0.0829 0.1091 0.7223
Schistosoma mansoni chromatin regulatory protein sir2 0.0129 0.0151 0.0151
Plasmodium falciparum plasmepsin X 0.0017 0.0001 0.0005
Loa Loa (eye worm) proteasome subunit beta type 1 0.0063 0.0063 0.0062
Trichomonas vaginalis calpain, putative 0.0829 0.1091 0.3174
Schistosoma mansoni hypothetical protein 0.0043 0.0036 0.0036
Brugia malayi fibroinase precursor 0.0389 0.0501 0.0501
Echinococcus granulosus programmed cell death protein 0.0424 0.0548 0.0548
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0063 0.0063 0.0182
Onchocerca volvulus 0.0058 0.0056 0.0108
Trypanosoma cruzi I/6 autoantigen, putative 0.0366 0.047 0.047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0018 0.0018
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.012 0.014 0.0406
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.1034 0.1367 0.1366
Brugia malayi Papain family cysteine protease containing protein 0.0389 0.0501 0.0501
Plasmodium vivax vivapain-1 0.0694 0.091 0.2733
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Mycobacterium ulcerans hypothetical protein 0.0043 0.0035 0.0598
Entamoeba histolytica cysteine proteinase, putative 0.1142 0.1511 0.681
Trichomonas vaginalis conserved hypothetical protein 0.0366 0.047 0.1367
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0122 0.0901
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0006 0.0006
Plasmodium falciparum cysteine proteinase falcipain 3 0.1142 0.1511 1
Leishmania major i/6 autoantigen-like protein 0.0366 0.047 0.1277
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0829 0.1091 0.2966
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0501 0.1456
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Toxoplasma gondii ABC1 family protein 0.0072 0.0075 0.0217
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1269 0.1681 0.457
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0006 0.0045
Leishmania major proteasome beta 5 subunit, putative 0.0081 0.0087 0.0236
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0015 0.0044
Entamoeba histolytica calmodulin, putative 0.0366 0.047 0.2108
Plasmodium vivax serine-repeat antigen (SERA) 0.0389 0.0501 0.1503
Loa Loa (eye worm) hypothetical protein 0.0389 0.0501 0.05
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Leishmania major calmodulin-like protein 0.0366 0.047 0.1277
Leishmania major DNA polymerase eta, putative 0.0045 0.0038 0.0103
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0366 0.047 0.047
Echinococcus multilocularis Mastin 0.0043 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.1142 0.1511 0.1511
Trypanosoma cruzi calmodulin, putative 0.0366 0.047 0.047
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.6709 0.8986 0.8986
Giardia lamblia Cathepsin L precursor 0.0389 0.0501 0.1456
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0041 0.0304
Echinococcus multilocularis cathepsin L 0.0694 0.091 0.091
Leishmania major hypothetical protein, conserved 0.0205 0.0253 0.0689
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0063 0.0063 0.0414
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0015 0.0015
Brugia malayi calpain 5 0.1668 0.2217 0.2217
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0129 0.0151 0.041
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Echinococcus granulosus neurocalcin 0.0366 0.047 0.047
Schistosoma mansoni hypothetical protein 0.0051 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Brugia malayi prolyl oligopeptidase family protein 0.012 0.014 0.014
Trichomonas vaginalis calmodulin, putative 0.0366 0.047 0.1367
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0011
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.2757 0.3679 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0043 0.0035 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0081 0.008
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1073 0.1419 0.1419
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0501 0.1456
Mycobacterium tuberculosis Conserved protein 0.0072 0.0075 0.0551
Trypanosoma brucei hypothetical protein, conserved 0.0366 0.047 0.1277
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0063 0.0063 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Schistosoma mansoni cathepsin B (C01 family) 0.0389 0.0501 0.0501
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0039 0.0031 0.0031
Giardia lamblia Cathepsin B precursor 0.0389 0.0501 0.1456
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0138 0.1019
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0002 0.0001
Mycobacterium tuberculosis Conserved protein 0.0072 0.0075 0.0551
Loa Loa (eye worm) cytochrome P450 0.0021 0.0006 0.0005
Echinococcus granulosus chromatin regulatory protein sir2 0.0129 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.012 0.014 0.0139
Echinococcus multilocularis Calcium binding protein 0.0058 0.0056 0.0056
Leishmania major calmodulin, putative 0.0366 0.047 0.1277
Giardia lamblia Hypothetical protein 0.0389 0.0501 0.1456
Entamoeba histolytica hypothetical protein, conserved 0.012 0.014 0.0616
Trypanosoma brucei centrin-3 0.0424 0.0548 0.149
Toxoplasma gondii hypothetical protein 0.0829 0.1091 0.3174
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Schistosoma mansoni hypothetical protein 0.0043 0.0035 0.0035
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0033 0.0023 0.0061
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0007 0.0007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1177 0.1558 0.1558
Trypanosoma cruzi cysteine peptidase, putative 0.0694 0.091 0.091
Brugia malayi Papain family cysteine protease containing protein 0.0694 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0305 0.0388 0.0387
Brugia malayi PXA domain containing protein 0.0037 0.0029 0.0029
Echinococcus granulosus FTZ F1 alpha 0.003 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0099 0.0098
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1016 0.1343 0.365
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0138 0.0138
Schistosoma mansoni neuronal calcium sensor 0.0366 0.047 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Schistosoma mansoni rab 0.0366 0.047 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0332 0.0424 0.1233
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0146 0.0146
Trichomonas vaginalis centrin, putative 0.0366 0.047 0.1367
Leishmania major hypothetical protein, unknown function 0.0829 0.1091 0.2966
Toxoplasma gondii troponin c, isotype gamma, putative 0.0366 0.047 0.1367
Echinococcus multilocularis cpg binding protein 0.006 0.0059 0.0058
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.6275 0.8403 0.8403
Loa Loa (eye worm) hypothetical protein 0.0366 0.047 0.0469
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0017 0.0001 0.0002
Echinococcus granulosus cathepsin L 0.0694 0.091 0.091
Giardia lamblia Proteasome subunit beta type 2 0.0039 0.0031 0.0089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1027 0.1357 1
Trypanosoma brucei protein I/6 0.0366 0.047 0.1277
Schistosoma mansoni calpain C (C02 family) 0.2497 0.333 0.333
Brugia malayi proteasome subunit beta type 1 0.0063 0.0063 0.0063
Entamoeba histolytica prolyl oligopeptidase family protein 0.012 0.014 0.0616
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) RGS-3 protein 0.0037 0.0029 0.0028
Leishmania major cathepsin L-like protease 0.1142 0.1511 0.4107
Plasmodium vivax unspecified product 0.0694 0.091 0.2733
Echinococcus granulosus calumenin 0.0371 0.0477 0.0477
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2578 0.3439 0.3439
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.137 0.1817 0.494
Toxoplasma gondii histone deacetylase SIR2-like 0.0033 0.0023 0.0065
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0129 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0035
Echinococcus granulosus cathepsin b 0.7465 1 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0043 0.0036 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0006 0.0045
Leishmania major cathepsin L-like protease 0.1378 0.1828 0.497
Trypanosoma brucei calmodulin, putative 0.0371 0.0477 0.1296
Plasmodium falciparum serine repeat antigen 1 0.0389 0.0501 0.3313
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0099 0.0286
Brugia malayi beta-lactamase 0.0072 0.0075 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0501 0.0501
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0694 0.091 0.091
Schistosoma mansoni calmodulin 0.0366 0.047 0.047
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0389 0.0501 0.0501
Giardia lamblia Cathepsin L precursor 0.0389 0.0501 0.1456
Plasmodium vivax glutathione reductase, putative 0.0047 0.0041 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0186 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.03 0.038 0.1034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0099 0.0098
Trypanosoma brucei unspecified product 0.0019 0.0004 0.0011
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1034 0.1367 0.1366
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1142 0.1511 0.4394
Onchocerca volvulus 0.0028 0.0015 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0138 0.234
Loa Loa (eye worm) cysteine protease 0.1142 0.1511 0.151
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.026 0.0327 0.0889
Brugia malayi hypothetical protein 0.0233 0.0292 0.0292
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0006 0.0016
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0012 0.0032
Entamoeba histolytica hypothetical protein 0.0037 0.0029 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0033 0.0023 0.0086
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.7465 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0389 0.0501 0.1456
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0456 0.0591 0.0591
Trypanosoma brucei prolyl endopeptidase 0.1147 0.1519 0.4128
Echinococcus multilocularis programmed cell death protein 0.0424 0.0548 0.0548
Loa Loa (eye worm) myosin Light Chain family member 0.0063 0.0063 0.0062
Brugia malayi Calmodulin-like protein 0.0366 0.047 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0075 0.0075
Giardia lamblia Programmed cell death protein-like protein 0.0058 0.0056 0.0163
Echinococcus multilocularis prolyl endopeptidase 0.1147 0.1519 0.1519
Plasmodium falciparum proteasome subunit beta type-5 0.0081 0.0087 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0837 0.1101 0.3203
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0033 0.0023 0.0023
Trichomonas vaginalis calmodulin, putative 0.0371 0.0477 0.1387
Trypanosoma cruzi cruzipain precursor, putative 0.0305 0.0388 0.0388
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0018 0.0018
Giardia lamblia Cysteine protease 0.0389 0.0501 0.1456
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0041 0.004
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0038 0.0038
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0122 0.0901
Loa Loa (eye worm) programmed cell death protein 6 0.0371 0.0477 0.0476
Onchocerca volvulus 0.003 0.0018 0.0034
Onchocerca volvulus 0.0027 0.0014 0.0026
Echinococcus granulosus dnaJ subfamily B 0.0409 0.0528 0.0528
Trichomonas vaginalis myosin light chain 1, putative 0.0366 0.047 0.1367
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0001 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0018 0.0018
Loa Loa (eye worm) calpain 5 0.1668 0.2217 0.2216
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.03 0.038 0.1034
Echinococcus granulosus geminin 0.0334 0.0427 0.0427
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0023 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0006 0.0045
Echinococcus multilocularis Myosin regulatory light chain 0.0058 0.0056 0.0056
Trypanosoma brucei SIR2-like protein 4, putative 0.0033 0.0023 0.0061
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.012 0.014 0.014
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0389 0.0501 0.1503
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.2757 0.3679 1
Leishmania major cathepsin L-like protease 0.1378 0.1828 0.497
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0142 0.0169 0.0492
Leishmania major cytochrome p450-like protein 0.0021 0.0006 0.0016
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0039 0.0031 0.0089
Echinococcus granulosus calpain A 0.2497 0.333 0.333
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0012 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Echinococcus multilocularis calcyphosin protein 0.0058 0.0056 0.0056
Trichomonas vaginalis calmodulin, putative 0.0366 0.047 0.1367
Brugia malayi Cytochrome P450 family protein 0.0021 0.0006 0.0006
Toxoplasma gondii EF hand domain-containing protein 0.0366 0.047 0.1367
Leishmania major centrin, putative 0.0366 0.047 0.1277
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0129 0.0151 0.0666
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0041 0.0041
Echinococcus multilocularis calpain 5 0.2497 0.333 0.333
Entamoeba histolytica cysteine proteinase, putative 0.0694 0.091 0.4097
Leishmania major calmodulin, putative 0.0366 0.047 0.1277
Giardia lamblia Hypothetical protein 0.0389 0.0501 0.1456
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1145 0.1515 0.1515
Brugia malayi cathepsin Z-like cysteine proteinase 0.0389 0.0501 0.0501
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Trichomonas vaginalis calcium binding protein, putative 0.0366 0.047 0.1367
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0001 0.0001
Toxoplasma gondii calmodulin, putative 0.0058 0.0056 0.0163
Echinococcus multilocularis programmed cell death protein 6 0.0063 0.0063 0.0063
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0033 0.0023 0.0149
Schistosoma mansoni hypothetical protein 0.0125 0.0146 0.0146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.2684 0.3582 0.3581
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0389 0.0501 0.1503
Brugia malayi prolyl oligopeptidase family protein 0.1147 0.1519 0.1519
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0138 0.234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0039 0.0031 0.0083
Echinococcus granulosus EF hand domain containing family member A2 0.0371 0.0477 0.0477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Brugia malayi proteasome subunit beta type 2 0.0039 0.0031 0.0031
Echinococcus granulosus axis inhibition protein axin 0.0037 0.0029 0.0028
Toxoplasma gondii calcium binding protein precursor, putative 0.0058 0.0056 0.0163
Plasmodium vivax unspecified product 0.0305 0.0388 0.1164
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0006 0.0103
Echinococcus multilocularis glycoprotein Antigen 5 0.0043 0.0035 0.0035
Echinococcus granulosus beta-adrenergic receptor kinase 0.0037 0.0029 0.0028
Trypanosoma cruzi calmodulin, putative 0.0366 0.047 0.047
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0389 0.0501 0.1503
Loa Loa (eye worm) prolyl oligopeptidase 0.012 0.014 0.0139
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0006 0.0103
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.002 0.002
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0039 0.0031 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Brugia malayi glutathione reductase 0.0047 0.0041 0.0041
Brugia malayi cathepsin F-like cysteine proteinase 0.0389 0.0501 0.0501
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0037 0.0029 0.0029
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0081 0.0087 0.0236
Schistosoma mansoni survival motor neuron protein 0.0048 0.0042 0.0042
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0389 0.0501 0.1503
Toxoplasma gondii microneme protein MIC17A 0.0028 0.0015 0.0044
Trypanosoma cruzi cysteine protease, putative 0.0694 0.091 0.091
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0038 0.0038
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2578 0.3439 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0006 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Plasmodium falciparum plasmepsin IX 0.0017 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0045 0.0038 0.0037
Schistosoma mansoni ef hand domain family member A2 0.0366 0.047 0.047
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0041 0.004
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.012 0.014 0.0406
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0006 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0501 0.1456
Toxoplasma gondii calmodulin CAM2 0.0058 0.0056 0.0163
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0035 0.0035
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0018 0.0018
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0058 0.0056 0.0108
Leishmania major hypothetical protein, conserved 0.0366 0.047 0.1277
Leishmania major silent information regulator 2, putative 0.0129 0.0151 0.041
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.012 0.014 0.014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0004
Schistosoma mansoni calpain-7 (C02 family) 0.2497 0.333 0.333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Schistosoma mansoni DNA polymerase eta 0.0045 0.0038 0.0038
Echinococcus granulosus regulator of G protein signaling 3 0.0037 0.0029 0.0028
Schistosoma mansoni hypothetical protein 0.0039 0.0031 0.0031
Toxoplasma gondii hypothetical protein 0.0028 0.0015 0.0044
Trichomonas vaginalis calmodulin, putative 0.0366 0.047 0.1367
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0006 0.0103
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0617 0.0807 0.0806
Trypanosoma brucei calpain-like protein, putative 0.2497 0.333 0.9052
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0012 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0018 0.0017
Toxoplasma gondii exonuclease III APE 0.0019 0.0004 0.001
Loa Loa (eye worm) calpain D 0.0829 0.1091 0.1091
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0366 0.047 0.047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0018 0.0018
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0001 0.0001
Schistosoma mansoni z-protein (S1r protein) 0.0037 0.0029 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Schistosoma mansoni myosin light chain 0.0058 0.0056 0.0056
Trichomonas vaginalis caltractin, putative 0.0058 0.0056 0.0163
Leishmania major hypothetical protein, conserved 0.0025 0.0012 0.0032
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0129 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Echinococcus granulosus tissue type plasminogen activator 0.0043 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0205 0.0253 0.0689
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0033 0.0023 0.0149
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0006 0.0045
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0018 0.0018
Brugia malayi calpain family protein 1 0.6343 0.8494 0.8494
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1142 0.1511 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0006 0.0045
Loa Loa (eye worm) fibroinase 0.1142 0.1511 0.151
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0142 0.0169 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Loa Loa (eye worm) hypothetical protein 0.0389 0.0501 0.05
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Echinococcus multilocularis programmed cell death protein 0.0424 0.0548 0.0548
Echinococcus granulosus Regulator of G protein signaling 20 0.0037 0.0029 0.0028
Toxoplasma gondii histone deacetylase SIR2 0.0033 0.0023 0.0065
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0006 0.0045
Trypanosoma brucei Component of motile flagella 41 0.0366 0.047 0.1277
Schistosoma mansoni Mername-AA248 (C02 family) 0.2497 0.333 0.333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0205 0.0253 0.0689
Brugia malayi calpain 7 0.2497 0.333 0.333
Onchocerca volvulus 0.0048 0.0043 0.0082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.2757 0.3679 0.3679
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1145 0.1515 0.1515
Trichomonas vaginalis calcineurin B subunit, putative 0.0366 0.047 0.1367
Schistosoma mansoni chromatin regulatory protein sir2 0.0142 0.0169 0.0169
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0205 0.0253 0.0689
Schistosoma mansoni cpg binding protein 0.0057 0.0054 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.004 0.004
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0366 0.047 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0039 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0028 0.0015 0.0044
Onchocerca volvulus 0.0366 0.047 0.0913
Trypanosoma cruzi small myristoylated protein 1-2 0.0354 0.0453 0.0453
Leishmania major small myristoylated protein-3, putative 0.03 0.038 0.1034
Giardia lamblia Cathepsin B precursor 0.0389 0.0501 0.1456
Echinococcus multilocularis chromatin regulatory protein sir2 0.0129 0.0151 0.0151
Leishmania major cytochrome p450-like protein 0.0047 0.0041 0.0111
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0205 0.0253 0.0689
Trichomonas vaginalis centrin, putative 0.0058 0.0056 0.0163
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0006 0.0006
Plasmodium falciparum plasmepsin VIII, putative 0.0017 0.0001 0.0005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.137 0.1817 0.1817
Echinococcus granulosus calcium uptake protein 1 0.0371 0.0477 0.0477
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1141 0.151 0.151
Echinococcus multilocularis calpain A 0.6715 0.8993 0.8993
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0075 0.1266
Brugia malayi Regulator of G protein signaling domain containing protein 0.0037 0.0029 0.0029
Onchocerca volvulus 0.0366 0.047 0.0913
Leishmania major cathepsin L-like protease 0.1142 0.1511 0.4107
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0389 0.0501 0.1456
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.012 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0142 0.0169 0.0168
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.1142 0.1511 0.4107
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0366 0.047 0.047
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0205 0.0253 0.0689
Toxoplasma gondii aspartyl protease 0.0017 0.0001 0.0002
Trypanosoma brucei trypanothione reductase 0.0047 0.0041 0.0112
Entamoeba histolytica grainin 2 0.0058 0.0056 0.0238
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.2757 0.3679 0.3679
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0456 0.0591 0.4353
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0077 0.0076
Trypanosoma cruzi 20S proteasome subunit 0.0039 0.0031 0.003
Entamoeba histolytica cysteine protease, putative 0.0389 0.0501 0.2246
Schistosoma mansoni neuronal calcium sensor 0.0366 0.047 0.047
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0075 0.0075
Schistosoma mansoni axis inhibition protein axin 0.0037 0.0029 0.0028
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0015 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0075 0.0217
Brugia malayi A-kinase anchor protein 10, precursor 0.0037 0.0029 0.0029
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.2497 0.333 0.333
Onchocerca volvulus 0.3846 0.5142 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0075 0.0217
Giardia lamblia Cathepsin B precursor 0.0389 0.0501 0.1456
Echinococcus multilocularis cathepsin b 0.7465 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0018 0.0018
Schistosoma mansoni cytochrome P450 0.0021 0.0006 0.0006
Onchocerca volvulus Cathepsin F homolog 0.1142 0.1511 0.2937
Brugia malayi hypothetical protein 0.0148 0.0177 0.0177
Toxoplasma gondii calmodulin CAM1 0.0371 0.0477 0.1387
Plasmodium vivax vivapain-2 0.1142 0.1511 0.4537
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1159 0.1534 0.417
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0366 0.047 0.1277
Leishmania major DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Loa Loa (eye worm) transcriptional regulator 0.0033 0.0023 0.0022
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0006 0.0016
Leishmania major cysteine peptidase A (CPA) 0.1142 0.1511 0.4107
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0075 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0004 0.0025
Giardia lamblia Calmodulin 0.0058 0.0056 0.0163
Toxoplasma gondii thioredoxin reductase 0.0047 0.0041 0.012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0138 0.1019
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0205 0.0253 0.0253
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.012 0.014 0.038
Trypanosoma brucei small myristoylated protein 1-1 0.0354 0.0453 0.1231
Schistosoma mansoni hypothetical protein 0.003 0.0018 0.0018
Entamoeba histolytica cysteine protease, putative 0.0694 0.091 0.4097
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0253 0.0253
Brugia malayi calcium-binding protein 0.0366 0.047 0.047
Brugia malayi Proteasome A-type and B-type family protein 0.0081 0.0087 0.0087
Onchocerca volvulus 0.0028 0.0015 0.0028
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0001 0.0002
Loa Loa (eye worm) sirtuin 4 0.0033 0.0023 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1378 0.1828 0.497
Onchocerca volvulus 0.0389 0.0501 0.0972
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0004 0.0029
Trichomonas vaginalis set domain proteins, putative 0.0702 0.0921 0.2678
Plasmodium falciparum plasmepsin III 0.0017 0.0001 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1142 0.1511 0.151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1142 0.1511 0.4394
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0366 0.047 0.047
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0041 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0829 0.1091 0.1091
Onchocerca volvulus 0.1142 0.1511 0.2937
Mycobacterium ulcerans proteasome PrcB 0.0081 0.0087 0.147
Entamoeba histolytica calcium binding family protein 0.0366 0.047 0.2108
Plasmodium falciparum serine repeat antigen 9 0.0389 0.0501 0.3313
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0072 0.0075 0.0074
Leishmania major small myristoylated protein-1 0.0354 0.0453 0.1231
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0075 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.014 0.014
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.0837 0.1101 0.1101
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0138 0.1019
Onchocerca volvulus 0.1142 0.1511 0.2937
Onchocerca volvulus 0.0028 0.0015 0.0028
Brugia malayi CXXC zinc finger family protein 0.0057 0.0054 0.0054
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0018 0.0018
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0 0.5
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0023 0.0023
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0063 0.0063 0.017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0002 0.0001
Echinococcus multilocularis neuronal calcium sensor 0.0366 0.047 0.047
Schistosoma mansoni chromatin regulatory protein sir2 0.0033 0.0023 0.0023
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0058 0.0056 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1142 0.1511 0.4394
Leishmania major hypothetical protein, conserved 0.0205 0.0253 0.0689
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.1034 0.1367 0.3714
Giardia lamblia Sirtuin type 2 0.0033 0.0023 0.0065
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1147 0.1519 0.1519
Brugia malayi Probable myosin regulatory light chain 0.0063 0.0063 0.0063
Entamoeba histolytica cysteine proteinase, putative 0.0694 0.091 0.4097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0501 0.0501
Leishmania major META domain containing protein 0.0205 0.0253 0.0689
Trypanosoma cruzi hypothetical protein, conserved 0.0332 0.0424 0.0424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0018 0.0017
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0366 0.047 0.047
Echinococcus granulosus dna polymerase eta 0.0045 0.0038 0.0038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0023 0.0065
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.03 0.038 0.038
Echinococcus multilocularis gamma secretase subunit aph 1 0.0256 0.0322 0.0322
Leishmania major hypothetical protein, conserved 0.0043 0.0036 0.0097
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0018 0.0018
Brugia malayi transcriptional regulator, Sir2 family protein 0.0033 0.0023 0.0023
Echinococcus granulosus cathepsin l cysteine peptidase 0.1142 0.1511 0.1511
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0142 0.0169 0.0492
Brugia malayi PAN domain containing protein 0.0028 0.0015 0.0015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.2497 0.333 0.333
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0006 0.0045
Trypanosoma cruzi calpain cysteine peptidase, putative 0.2757 0.3679 0.3679
Brugia malayi RasGEF domain containing protein 0.0058 0.0056 0.0056
Trypanosoma cruzi oligopeptidase b 0.0456 0.0591 0.0591
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0004 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0011
Trypanosoma cruzi centrin, putative 0.0424 0.0548 0.0548
Echinococcus multilocularis calbindin 32 0.0371 0.0477 0.0477
Echinococcus granulosus calpain A 0.6715 0.8993 0.8993
Trypanosoma cruzi centrin, putative 0.0424 0.0548 0.0548
Echinococcus multilocularis cathepsin L cysteine protease 0.1142 0.1511 0.1511
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0033 0.0023 0.0023
Schistosoma mansoni cercarial elastase (S01 family) 0.0043 0.0035 0.0035
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0033 0.0023 0.0065
Giardia lamblia Hypothetical protein 0.0371 0.0477 0.1387
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0043 0.0035 0.0035
Trypanosoma cruzi caltractin, putative 0.0366 0.047 0.047
Trypanosoma brucei calpain-like protein, putative 0.2757 0.3679 1
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0075 0.1175
Echinococcus multilocularis cathepsin b 0.7465 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0389 0.0501 0.0501
Toxoplasma gondii proteasome subunit beta type, putative 0.0081 0.0087 0.0253
Plasmodium vivax proteasome subunit beta type-2, putative 0.0039 0.0031 0.0091
Schistosoma mansoni calmodulin-related 0.0058 0.0056 0.0056
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.012 0.014 0.027
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0018 0.0018
Leishmania major DNA polymerase eta, putative 0.0031 0.002 0.0055
Trichomonas vaginalis calmodulin, putative 0.0366 0.047 0.1367
Leishmania major sir2-family protein-like protein 0.0033 0.0023 0.0061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0018 0.0018
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0389 0.0501 0.1456
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0127 0.0368
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0371 0.0477 0.0477
Trypanosoma cruzi major cysteine proteinase, putative 0.0389 0.0501 0.0501
Brugia malayi Trypsin family protein 0.0043 0.0035 0.0035

Activities

Activity type Activity value Assay description Source Reference
ED20 (functional) = 37 ug kg-1 Concentration required to reduce mean arterial blood pressure in rat after intravenous administration. ChEMBL. 7837224
ED50 (functional) = 0.41 ug kg-1 Inhibition of methacholine-induced ECG changes in the anesthetized rat after intravenous administration. ChEMBL. 7837224
ED50 (functional) = 6 ug kg-1 Inhibition of vasopressin-induced ECG changes in rat ChEMBL. 7837224
ED50 (functional) = 142 ug kg-1 Inhibition of methacholine-induced ECG changes in the anesthetized rat after oral administration. ChEMBL. 7837224
IC50 (functional) = 0.035 uM Vasorelaxation activity in the isolated endothelium-denuded rabbit aorta ChEMBL. 7837224
logP (ADMET) = 2.41 Partition coefficient (logP) ChEMBL. 7837224
Selectivity index (functional) = 8.6 Selectivity index of the compound as the ratio of doses requires to induce a reduction in MABP and that required to prevent ECG changes. ChEMBL. 7837224

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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